KEGG PATHWAY: spe03070

PATHWAY: spe03070

Entry

spe03070 Pathway

Name

Bacterial secretion system - Serratia proteamaculans

Description

Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.

Class

Environmental Information Processing; Membrane transport

Pathway map

spe03070

Bacterial secretion system

Module

spe_M00325	alpha-Hemolysin/cyclolysin transport system [PATH:spe03070]
spe_M00331	Type II general secretion system [PATH:spe03070]
spe_M00332	Type III secretion system [PATH:spe03070]
spe_M00333	Type IV secretion system [PATH:spe03070]
spe_M00334	Type VI secretion system [PATH:spe03070]
spe_M00335	Sec (secretion) system [PATH:spe03070]
spe_M00336	Twin-arginine translocation (Tat) system [PATH:spe03070]

Other DBs

BSID:

58702

GO:

0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953

Organism

Serratia proteamaculans [GN:spe]

Gene

Spro_4268	tolC; outer membrane channel protein [KO:K12340]
Spro_4251	general secretion pathway protein D; K02453 general secretion pathway protein D [KO:K02453]
Spro_3107	putative secretion protein; K02465 general secretion pathway protein S [KO:K02465]
Spro_4252	hypothetical protein; K02452 general secretion pathway protein C [KO:K02452]
Spro_4249	general secretion pathway protein F; K02455 general secretion pathway protein F [KO:K02455]
Spro_4248	general secretion pathway protein G; K02456 general secretion pathway protein G [KO:K02456]
Spro_4247	general secretion pathway protein H; K02457 general secretion pathway protein H [KO:K02457]
Spro_4246	general secretion pathway protein I; K02458 general secretion pathway protein I [KO:K02458]
Spro_4245	general secretion pathway protein J; K02459 general secretion pathway protein J [KO:K02459]
Spro_4244	general secretion pathway protein K; K02460 general secretion pathway protein K [KO:K02460]
Spro_4243	general secretion pathway L; K02461 general secretion pathway protein L [KO:K02461]
Spro_4242	hypothetical protein; K02462 general secretion pathway protein M [KO:K02462]
Spro_4250	general secretory pathway protein E; K02454 general secretion pathway protein E [KO:K02454]
Spro_1063	secD; preprotein translocase subunit SecD [KO:K03072]
Spro_1064	secF; preprotein translocase subunit SecF [KO:K03074]
Spro_0271	secE; preprotein translocase subunit SecE [KO:K03073]
Spro_0486	secG; preprotein translocase subunit SecG [KO:K03075]
Spro_4524	secY; preprotein translocase subunit SecY [KO:K03076]
Spro_1062	yajC; preprotein translocase subunit YajC [KO:K03210]
Spro_0028	putative inner membrane protein translocase component YidC; K03217 preprotein translocase subunit YidC [KO:K03217]
Spro_0770	preprotein translocase subunit SecA; K03070 preprotein translocase subunit SecA [KO:K03070]
Spro_0769	SecA regulator SecM; K13301 secretion monitor [KO:K13301]
Spro_0221	signal recognition particle-docking protein FtsY; K03110 fused signal recognition particle receptor [KO:K03110]
Spro_4816	preprotein translocase subunit SecB; K03071 preprotein translocase subunit SecB [KO:K03071]
Spro_0851	signal recognition particle protein; K03106 signal recognition particle subunit SRP54 [KO:K03106]
Spro_0251	twin arginine-targeting protein translocase; K03116 sec-independent protein translocase protein TatA [KO:K03116]
Spro_0252	twin-arginine translocation protein; K03117 sec-independent protein translocase protein TatB [KO:K03117]
Spro_0253	twin-arginine protein translocation system subunit TatC; K03118 sec-independent protein translocase protein TatC [KO:K03118]
Spro_1194	tatE; twin arginine translocase protein A [KO:K03425]
Spro_4481	hemolysin activator HlyB domain-containing protein; K11017 hemolysin activation/secretion protein [KO:K11017]
Spro_4482	filamentous hemagglutinin outer membrane protein; K11016 hemolysin [KO:K11016]
Spro_1788	hypothetical protein; K11903 type VI secretion system secreted protein Hcp [KO:K11903]
Spro_3005	hypothetical protein; K11903 type VI secretion system secreted protein Hcp [KO:K11903]
Spro_2997	putative lipoprotein; K11906 type VI secretion system protein VasD [KO:K11906]
Spro_1802	hypothetical protein; K11906 type VI secretion system protein VasD [KO:K11906]
Spro_3000	ImcF domain-containing protein; K11891 type VI secretion system protein ImpL [KO:K11891]
Spro_1798	ImcF domain-containing protein; K11891 type VI secretion system protein ImpL [KO:K11891]
Spro_2999	hypothetical protein; K11892 type VI secretion system protein ImpK [KO:K11892]
Spro_1786	hypothetical protein; K11892 type VI secretion system protein ImpK [KO:K11892]
Spro_3013	ATPase; K11907 type VI secretion system protein VasG [KO:K11907]
Spro_1789	ATPase; K11907 type VI secretion system protein VasG [KO:K11907]

Compound

C00002

ATP

Reference

PMID:11173102

Authors

Kim JF.

Title

Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.

Journal

Trends Genet 17:65-9 (2001)

Reference

PMID:11309112

Authors

Plano GV, Day JB, Ferracci F.

Title

Type III export: new uses for an old pathway.

Journal

Mol Microbiol 40:284-93 (2001)

Reference

PMID:11413015

Authors

Gauthier A, Finlay BB.

Title

Bacterial pathogenesis: the answer to virulence is in the pore.

Journal

Curr Biol 11:R264-7 (2001)

Reference

PMID:10047550

Authors

Burns DL.

Title

Biochemistry of type IV secretion.

Journal

Curr Opin Microbiol 2:25-9 (1999)

Reference

PMID:10920394

Authors

Christie PJ, Vogel JP.

Title

Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.

Journal

Trends Microbiol 8:354-60 (2000)

Reference

PMID:11309113

Authors

Christie PJ.

Title

Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.

Journal

Mol Microbiol 40:294-305 (2001)

Reference

PMID:10481178

Authors

Nunn D.

Title

Bacterial type II protein export and pilus biogenesis: more than just homologies?

Journal

Trends Cell Biol 9:402-8 (1999)

Reference

PMID:11309111

Authors

Sandkvist M.

Title

Biology of type II secretion.

Journal

Mol Microbiol 40:271-83 (2001)

Reference

PMID:11349009

Authors

Sandkvist M.

Title

Type II secretion and pathogenesis.

Journal

Infect Immun 69:3523-35 (2001)

Reference

PMID:15546664

Authors

Delepelaire P

Title

Type I secretion in gram-negative bacteria.

Journal

Biochim Biophys Acta 1694:149-61 (2004)

Reference

PMID:18406342

Authors

Hazes B, Frost L

Title

Towards a systems biology approach to study type II/IV secretion systems.

Journal

Biochim Biophys Acta 1778:1839-50 (2008)

Reference

PMID:16448494

Authors

Johnson TL, Abendroth J, Hol WG, Sandkvist M

Title

Type II secretion: from structure to function.

Journal

FEMS Microbiol Lett 255:175-86 (2006)

Reference

PMID:15546665

Authors

Filloux A

Title

The underlying mechanisms of type II protein secretion.

Journal

Biochim Biophys Acta 1694:163-79 (2004)

Reference

PMID:19396170

Authors

Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC

Title

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.

Journal

Nat Struct Mol Biol 16:468-76 (2009)

Reference

PMID:15590783

Authors

Ghosh P

Title

Process of protein transport by the type III secretion system.

Journal

Microbiol Mol Biol Rev 68:771-95 (2004)

Reference

PMID:12360191

Authors

Cornelis GR

Title

The Yersinia Ysc-Yop 'type III' weaponry.

Journal

Nat Rev Mol Cell Biol 3:742-52 (2002)

Reference

PMID:17215876

Authors

Baron C

Title

VirB8: a conserved type IV secretion system assembly factor and drug target.

Journal

Biochem Cell Biol 84:890-9 (2006)

Reference

PMID:17943123

Authors

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S

Title

Helicobacter exploits integrin for type IV secretion and kinase activation.

Journal

Nature 449:862-6 (2007)

Reference

PMID:16092524

Authors

Christie PJ, Cascales E

Title

Structural and dynamic properties of bacterial type IV secretion systems (review).

Journal

Mol Membr Biol 22:51-61 (2005)

Reference

PMID:15546668

Authors

Christie PJ

Title

Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.

Journal

Biochim Biophys Acta 1694:219-34 (2004)

Reference

PMID:15590781

Authors

Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D

Title

Type V protein secretion pathway: the autotransporter story.

Journal

Microbiol Mol Biol Rev 68:692-744 (2004)

Reference

PMID:9778731

Authors

Henderson IR, Navarro-Garcia F, Nataro JP

Title

The great escape: structure and function of the autotransporter proteins.

Journal

Trends Microbiol 6:370-8 (1998)

Reference

PMID:18524912

Authors

Filloux A, Hachani A, Bleves S

Title

The bacterial type VI secretion machine: yet another player for protein transport across membranes.

Journal

Microbiology 154:1570-83 (2008)

Reference

PMID:19251641

Authors

Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ

Title

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.

Journal

Proc Natl Acad Sci U S A 106:4154-9 (2009)

Reference

PMID:17603507

Authors

Kulasekara HD, Miller SI

Title

Threonine phosphorylation times bacterial secretion.

Journal

Nat Cell Biol 9:734-6 (2007)

Reference

PMID:18078384

Authors

Driessen AJ, Nouwen N

Title

Protein translocation across the bacterial cytoplasmic membrane.

Journal

Annu Rev Biochem 77:643-67 (2008)

Reference

PMID:14641032

Authors

Pool MR

Title

Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?

Journal

Biochem Soc Trans 31:1232-7 (2003)

Reference

PMID:19299134

Authors

Desvaux M, Hebraud M, Talon R, Henderson IR

Title

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.

Journal

Trends Microbiol 17:139-45 (2009)

Reference

PMID:15063851

Authors

Nakatogawa H, Murakami A, Ito K

Title

Control of SecA and SecM translation by protein secretion.

Journal

Curr Opin Microbiol 7:145-50 (2004)

KO pathway

ko03070

All links

Pathway (4)   
   KEGG MODULE (3)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG GENES (41)   
All databases (46)   

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