Protein export - Streptococcus pyogenes MGAS315 (serotype M3)

The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.

Genetic Information Processing; Folding, sorting and degradation

Streptococcus pyogenes MGAS315 (serotype M3) [GN:spg]

PMID:10087917

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Trends Biochem Sci 24:17-22 (1999)

PMID:10652088

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PMID:10747959

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J Biol Chem 275:16717-22 (2000)

PMID:11007775

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TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.

J Biol Chem 275:41350-7 (2000)

PMID:18046402

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Nature 450:663-9 (2007)

PMID:17368028

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Trends Microbiol 15:203-10 (2007)

PMID:16212506

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PMID:12475201

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PMID:10924740

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PMID:17259602

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PMID:19299134

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Trends Microbiol 17:139-45 (2009)

PMID:15063851

Nakatogawa H, Murakami A, Ito K

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Curr Opin Microbiol 7:145-50 (2004)