KEGG   PATHWAY: spi00053Help
Entry
spi00053                    Pathway                                

Name
Ascorbate and aldarate metabolism - Streptococcus pyogenes MGAS10750 (serotype M4)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
spi00053  Ascorbate and aldarate metabolism
spi00053

Ortholog table
Module
spi_M00283  PTS system, ascorbate-specific II component [PATH:spi00053]
spi_M00550  Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:spi00053]
Other DBs
BSID: 34659
GO: 0019852 0019572
Organism
Streptococcus pyogenes MGAS10750 (serotype M4) [GN:spi]
Gene
MGAS10750_Spy0469  hasB; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
MGAS10750_Spy0156  PTS system, 3-keto-L-gulonate specific IIA component [KO:K02821] [EC:2.7.1.194]
MGAS10750_Spy1758  Transcription antiterminator, BglG family / PTS system, mannitol (Cryptic)-specific IIA component [KO:K02821] [EC:2.7.1.194]
MGAS10750_Spy0155  PTS system, 3-keto-L-gulonate specific IIB component [KO:K02822] [EC:2.7.1.194]
MGAS10750_Spy1757  PTS system, IIB component [KO:K02822] [EC:2.7.1.194]
MGAS10750_Spy0154  PTS system, 3-keto-L-gulonate specific IIC component [KO:K03475]
MGAS10750_Spy1756  Putative transport protein sgaT [KO:K03475]
MGAS10750_Spy0162  Metal-dependent hydrolase [KO:K03476] [EC:3.1.1.-]
MGAS10750_Spy0157  3-keto-L-gulonate-6-phosphate decarboxylase [KO:K03078] [EC:4.1.1.85]
MGAS10750_Spy0158  L-xylulose 5-phosphate 3-epimerase [KO:K03079] [EC:5.1.3.22]
MGAS10750_Spy0159  araD; L-ribulose-5-phosphate 4-epimerase [KO:K03077] [EC:5.1.3.4]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00618  3-Dehydro-L-gulonate
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
Reference
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
KO pathway
ko00053   

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