KEGG   PATHWAY: spm00523Help
Entry
spm00523                    Pathway                                

Name
Polyketide sugar unit biosynthesis - Streptococcus pyogenes MGAS8232 (serotype M18)
Class
Metabolism; Metabolism of terpenoids and polyketides
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Pathway map
Polyketide sugar unit biosynthesis
spm00523

All organismsOrtholog table
Module
dTDP-L-rhamnose biosynthesis [PATH:spm00523]
Organism
Streptococcus pyogenes MGAS8232 (serotype M18) [GN:spm]
Gene
cpsFO; glucose-1-phosphate thymidyl transferase [KO:K00973] [EC:2.7.7.24]
cpsFQ; putative dTDP-glucose-4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
cpsFP; putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase [KO:K01790] [EC:5.1.3.13]
putative dTDP-4-keto-L-rhamnose reductase; K00067 dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] [KO:K00067] [EC:1.1.1.133]
Compound
C00103  
D-Glucose 1-phosphate
C00688  
dTDP-4-dehydro-beta-L-rhamnose
C00842  
dTDP-glucose
C03187  
dTDP-6-deoxy-beta-L-talose
C03319  
dTDP-L-rhamnose
C04268  
dTDP-4-amino-4,6-dideoxy-D-glucose
C06620  
dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C07277  
dTDP-D-fucose
C11460  
dTDP-4-oxo-5-C-methyl-L-rhamnose
C11907  
dTDP-4-oxo-6-deoxy-D-glucose
C11908  
3,6-Dideoxy-3-oxo-dTDP-D-glucose
C11909  
dTDP-3-oxo-4,6-dideoxy-D-glucose
C11910  
dTDP-3-amino-3,4,6-trideoxy-D-glucose
C11911  
dTDP-D-desosamine
C11912  
dTDP-6-deoxy-D-allose
C11915  
dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose
C11916  
dTDP-L-mycarose
C11918  
Maltol
C11919  
dTDP-L-megosamine
C11920  
dTDP-L-olivose
C11921  
dTDP-L-oleandrose
C11922  
dTDP-4-oxo-2,6-dideoxy-D-glucose
C11925  
dTDP-3-amino-3,6-dideoxy-D-glucose
C11926  
dTDP-4-oxo-6-deoxy-D-allose
C11927  
dTDP-4-oxo-2,6-dideoxy-L-mannose
C11928  
dTDP-4-oxo-2,6-dideoxy-D-allose
C11933  
dTDP-D-mycaminose
C12318  
dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12481  
dTDP-5-dimethyl-L-lyxose
C18029  
dTDP-3-oxo-2,6-dideoxy-D-glucose
C18030  
dTDP-2,6-dideoxy-D-kanosamine
C18031  
dTDP-D-angolosamine
C18032  
dTDP-4-oxo-2,3,6-trideoxy-D-glucose
C18033  
dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose
C18034  
dTDP-D-forosamine
C18035  
dTDP-3-methyl-4-oxo-2,6-dideoxy-D-glucose
C21071  
dTDP-3-O-methyl-4-oxo-2,6-dideoxy-L-mannose
C21073  
dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose
C21074  
dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).
  Journal
Nat Prod Rep 18:190-227 (2001)
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
Reference
  Authors
Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR
  Title
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.
  Journal
Chem Biol 8:681-700 (2001)
Reference
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
Reference
  Authors
Amann S, Drager G, Rupprath C, Kirschning A, Elling L
  Title
(Chemo)enzymatic synthesis of dTDP-activated 2,6-dideoxysugars as building blocks of polyketide antibiotics.
  Journal
Carbohydr Res 335:23-32 (2001)
Reference
  Authors
Thibodeaux CJ, Melancon CE, Liu HW
  Title
Unusual sugar biosynthesis and natural product glycodiversification.
  Journal
Nature 446:1008-16 (2007)
Reference
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
Reference
(PMID:15609849 (Article in Russian))
  Authors
Mironov VA, Sergienko OV, Nastasiak IN, Danilenko VN.
  Title
Biogenesis and regulation of biosynthesis of erythromycins in Saccharopolyspora.
  Journal
Applied Biochemistry and Microbiology 40(6): 531-541 (2004)
Reference
  Authors
Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA
  Title
Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase.
  Journal
Chem Commun (Camb) 1079-81 (2006)
Reference
  Authors
Takahashi H, Liu YN, Chen H, Liu HW
  Title
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.
  Journal
J Am Chem Soc 127:9340-1 (2005)
Reference
  Authors
Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C, Salas JA
  Title
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.
  Journal
Antimicrob Agents Chemother 44:1266-75 (2000)
Reference
  Authors
Rodriguez L, Rodriguez D, Olano C, Brana AF, Mendez C, Salas JA
  Title
Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus.
  Journal
J Bacteriol 183:5358-63 (2001)
Reference
  Authors
Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H
  Title
TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.
  Journal
Appl Environ Microbiol 76:3869-77 (2010)
KO pathway
 

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