KEGG   PATHWAY: ssc04115Help
Entry
ssc04115                    Pathway                                
Name
p53 signaling pathway - Sus scrofa (pig)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
p53 signaling pathway
ssc04115

All organismsOrtholog table
Organism
Sus scrofa (pig) [GN:ssc]
Gene
ATM; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
serine/threonine-protein kinase ATR-like; K06640 serine/threonine-protein kinase ATR [EC:2.7.11.1] [KO:K06640] [EC:2.7.11.1]
CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
MDM2; Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) [KO:K06643] [EC:6.3.2.19]
protein Mdm4-like; K10127 protein Mdm4 [KO:K10127]
397276  
TP53; tumor protein p53 [KO:K04451]
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
cyclin-dependent kinase inhibitor 1-like; K06625 cyclin-dependent kinase inhibitor 1A [KO:K06625]
uncharacterized LOC100738589; K04503 cyclin D1 [KO:K04503]
397162  
CCND2; cyclin D2 [KO:K10151]
780426  
CCND3; cyclin D3 [KO:K10152]
CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
CCNE2; cyclin E2 [KO:K06626]
CCNE1; cyclin E1 [KO:K06626]
cyclin-dependent kinase-2 alpha; K02206 cyclin-dependent kinase 2 [EC:2.7.11.22] [KO:K02206] [EC:2.7.11.22]
733625  
SFN; stratifin [KO:K06644]
protein reprimo-like; K10128 reprimo, TP53-dependent G2 arrest mediator candidate [KO:K10128]
protein reprimo-like; K10128 reprimo, TP53-dependent G2 arrest mediator candidate [KO:K10128]
CCNB2; cyclin B2 [KO:K05868]
397662  
CCNB1; cyclin B1 [KO:K05868]
CCNB3; cyclin B3 [KO:K05868]
CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
GADD45G; growth arrest and DNA-damage-inducible, gamma [KO:K04402]
733669  
GADD45A; growth arrest and DNA-damage-inducible, alpha [KO:K04402]
GADD45B; growth arrest and DNA-damage-inducible, beta [KO:K04402]
G2 and S phase-expressed protein 1-like; K10129 G-2 and S-phase expressed protein 1 [KO:K10129]
396826  
FAS; Fas (TNF receptor superfamily, member 6) [KO:K04390]
595105  
CASP8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
594852  
BID; BH3 interacting domain death agonist [KO:K04726]
396633  
BAX; BCL2-associated X protein [KO:K02159]
397278  
PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
bcl-2-binding component 3-like; K10132 BCL2-binding component 3 [KO:K10132]
quinone oxidoreductase PIG3-like; K10133 tumor protein p53-inducible protein 3 [EC:1.-.-.-] [KO:K10133] [EC:1.-.-.-]
EI24; etoposide induced 2.4 mRNA [KO:K10134]
putative NFkB activating protein; K10135 scotin [KO:K10135]
protein shisa-5-like; K10135 scotin [KO:K10135]
PERP; PERP, TP53 apoptosis effector [KO:K10136]
zinc finger matrin-type protein 3-like; K10137 zinc finger, matrin type 3 [KO:K10137]
E3 ubiquitin-protein ligase SIAH1-like; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
E3 ubiquitin-protein ligase SIAH1-like; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
CYCS; cytochrome c, somatic [KO:K08738]
cytochrome c-like; K08738 cytochrome c [KO:K08738]
APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
caspase-9-like; K04399 caspase 9 [EC:3.4.22.62] [KO:K04399] [EC:3.4.22.62]
397244  
CASP3; caspase 3, apoptosis-related cysteine peptidase [KO:K02187] [EC:3.4.22.56]
448812  
IGFBP3; insulin-like growth factor binding protein 3 [KO:K10138]
397491  
IGF1; insulin-like growth factor 1 (somatomedin C) [KO:K05459]
396945  
SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [KO:K03982]
CD82; CD82 molecule [KO:K06509]
492313  
THBS1; thrombospondin 1 [KO:K16857]
SERPINB5; serpin peptidase inhibitor, clade B (ovalbumin), member 5 [KO:K10139]
DNA damage-binding protein 2-like; K10140 DNA damage-binding protein 2 [KO:K10140]
RRM2B; ribonucleotide reductase M2 B (TP53 inducible) [KO:K10808] [EC:1.17.4.1]
RRM2; ribonucleotide reductase M2 [KO:K10808] [EC:1.17.4.1]
sestrin-1-like; K10141 sestrin [KO:K10141]
SESN3; sestrin 3 [KO:K10141]
sestrin-2-like; K10141 sestrin [KO:K10141]
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
TSC2; tuberous sclerosis 2 [KO:K07207]
STEAP3; STEAP family member 3, metalloreductase [KO:K10142] [EC:1.16.1.-]
RFWD2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase [KO:K10143] [EC:6.3.2.19]
Pirh2; K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19] [KO:K10144] [EC:6.3.2.19]
595110  
CCNG1; cyclin G1 [KO:K10145]
cyclin-G2-like; K10146 cyclin G2 [KO:K10146]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
KO pathway
 
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