KEGG PATHWAY: ssc04120

PATHWAY: ssc04120

Entry

ssc04120 Pathway

Name

Ubiquitin mediated proteolysis - Sus scrofa (pig)

Description

Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

ssc04120

Ubiquitin mediated proteolysis

Module

ssc_M00379	SCF-MET30 complex [PATH:ssc04120]
ssc_M00380	SCF-BTRC complex [PATH:ssc04120]
ssc_M00381	SCF-SKP2 complex [PATH:ssc04120]
ssc_M00382	SCF-FBS complex [PATH:ssc04120]
ssc_M00383	ECV complex [PATH:ssc04120]
ssc_M00384	Cul3-SPOP complex [PATH:ssc04120]
ssc_M00385	Cul4-DDB1-DDB2 complex [PATH:ssc04120]
ssc_M00386	Cul4-DDB1-CSA complex [PATH:ssc04120]
ssc_M00387	SCF-FBW7 complex [PATH:ssc04120]
ssc_M00388	ECS complex [PATH:ssc04120]
ssc_M00389	APC/C complex [PATH:ssc04120]
ssc_M00407	SCF-CDC4 complex [PATH:ssc04120]
ssc_M00411	SCF-GRR1 complex [PATH:ssc04120]

Other DBs

BSID:

84468

GO:

0016567

Organism

Sus scrofa (pig) [GN:ssc]

Gene

100525439	UBA1; ubiquitin-like modifier activating enzyme 1 [KO:K03178] [EC:6.3.2.19]
100515263	SUMO-activating enzyme subunit 1-like; K10684 ubiquitin-like 1-activating enzyme E1 A [EC:6.3.2.19] [KO:K10684] [EC:6.3.2.19]
100739612	SUMO-activating enzyme subunit 2-like; K10685 ubiquitin-like 1-activating enzyme E1 B [EC:6.3.2.19] [KO:K10685] [EC:6.3.2.19]
100153428	UBA3; ubiquitin-like modifier activating enzyme 3 [KO:K10686] [EC:6.3.2.19]
100512631	UBA7; ubiquitin-like modifier activating enzyme 7 [KO:K10698] [EC:6.3.2.19]
100512547	UBA6; ubiquitin-like modifier activating enzyme 6 [KO:K10699] [EC:6.3.2.19]
100154142	ubiquitin-conjugating enzyme E2A; K10573 ubiquitin-conjugating enzyme E2 A [EC:6.3.2.19] [KO:K10573] [EC:6.3.2.19]
100513527	UBE2B; ubiquitin-conjugating enzyme E2B [KO:K10574] [EC:6.3.2.19]
100153133	UBE2C; ubiquitin-conjugating enzyme E2C [KO:K06688] [EC:6.3.2.19]
780417	UB2E2; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
780419	UB2D1; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
780418	UBE2D2; ubiquitin-conjugating enzyme E2D 2 [KO:K06689] [EC:6.3.2.19]
100523265	ubiquitin-conjugating enzyme E2 D3-like; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
100524597	ubiquitin-conjugating enzyme E2 D4-like; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
100626899	ubiquitin-conjugating enzyme E2 E1-like; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
100517862	NEDD8-conjugating enzyme UBE2F-like; K10687 ubiquitin-conjugating enzyme E2 F [EC:6.3.2.19] [KO:K10687] [EC:6.3.2.19]
100522828	ubiquitin-conjugating enzyme E2 G1-like; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19] [KO:K10575] [EC:6.3.2.19]
100624139	ubiquitin-conjugating enzyme E2 G2-like; K04555 ubiquitin-conjugating enzyme E2 G2 [EC:6.3.2.19] [KO:K04555] [EC:6.3.2.19]
100626356	ubiquitin-conjugating enzyme E2 H-like; K10576 ubiquitin-conjugating enzyme E2 H [EC:6.3.2.19] [KO:K10576] [EC:6.3.2.19]
100533196	UBE2I; ubiquitin-conjugating enzyme E2I [KO:K10577] [EC:6.3.2.19]
768104	UBE2J1; ubiquitin-conjugating enzyme E2, J1 [KO:K10578] [EC:6.3.2.19]
100523610	ubiquitin-conjugating enzyme E2 J2-like; K04554 ubiquitin-conjugating enzyme E2 J2 [EC:6.3.2.19] [KO:K04554] [EC:6.3.2.19]
100154268	UBE2L3; ubiquitin-conjugating enzyme E2L 3 [KO:K04552] [EC:6.3.2.19]
100514753	UBE2L6; ubiquitin-conjugating enzyme E2L 6 [KO:K04553] [EC:6.3.2.19]
100621774	NEDD8-conjugating enzyme Ubc12-like; K10579 ubiquitin-conjugating enzyme E2 M [EC:6.3.2.19] [KO:K10579] [EC:6.3.2.19]
100154647	ubiquitin-conjugating enzyme E2 N-like; K10580 ubiquitin-conjugating enzyme E2 N [EC:6.3.2.19] [KO:K10580] [EC:6.3.2.19]
100519842	ubiquitin-conjugating enzyme E2 N-like; K10580 ubiquitin-conjugating enzyme E2 N [EC:6.3.2.19] [KO:K10580] [EC:6.3.2.19]
100519047	ubiquitin-conjugating enzyme E2 O-like; K10581 ubiquitin-conjugating enzyme E2 O [EC:6.3.2.19] [KO:K10581] [EC:6.3.2.19]
100156747	UBE2Q1; ubiquitin-conjugating enzyme E2Q family member 1 [KO:K10582] [EC:6.3.2.19]
100518586	ubiquitin-conjugating enzyme E2Q-like protein 1-like; K10582 ubiquitin-conjugating enzyme E2 Q [EC:6.3.2.19] [KO:K10582] [EC:6.3.2.19]
100621770	UBE2Q2; ubiquitin-conjugating enzyme E2Q family member 2 [KO:K10582] [EC:6.3.2.19]
100620788	ubiquitin-conjugating enzyme E2 R1-like; K02207 ubiquitin-conjugating enzyme E2 R [EC:6.3.2.19] [KO:K02207] [EC:6.3.2.19]
100622914	ubiquitin-conjugating enzyme E2 S-like; K10583 ubiquitin-conjugating enzyme E2 S [EC:6.3.2.19] [KO:K10583] [EC:6.3.2.19]
100519034	ubiquitin-conjugating enzyme E2 U-like; K10584 ubiquitin-conjugating enzyme E2 U [EC:6.3.2.19] [KO:K10584] [EC:6.3.2.19]
100152196	UBE2W; ubiquitin-conjugating enzyme E2W (putative) [KO:K10688] [EC:6.3.2.19]
100523993	ubiquitin-conjugating enzyme E2 Z-like; K10585 ubiquitin-conjugating enzyme E2 Z [EC:6.3.2.19] [KO:K10585] [EC:6.3.2.19]
780416	UBC1; K04649 ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:6.3.2.19] [KO:K04649] [EC:6.3.2.19]
100049694	ubiquitin-conjugating BIR-domain enzyme; K10586 baculoviral IAP repeat-containing protein 6 (apollon) [EC:6.3.2.19] [KO:K10586] [EC:6.3.2.19]
100522589	UBE3A; ubiquitin protein ligase E3A [KO:K10587] [EC:6.3.2.19]
100157435	UBE3B; ubiquitin protein ligase E3B [KO:K10588] [EC:6.3.2.19]
100511906	ubiquitin-protein ligase E3C-like; K10589 ubiquitin-protein ligase E3 C [EC:6.3.2.19] [KO:K10589] [EC:6.3.2.19]
100521958	E3 ubiquitin-protein ligase SMURF1-like; K04678 E3 ubiquitin ligase SMURF1/2 [EC:6.3.2.19] [KO:K04678] [EC:6.3.2.19]
100621443	SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:6.3.2.19]
100157283	WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:6.3.2.19]
100626361	NEDD4-like E3 ubiquitin-protein ligase WWP2-like; K05630 atrophin-1 interacting protein 2 (WW domain containing E3 ubiquitin protein ligase 2) [EC:6.3.2.19] [KO:K05630] [EC:6.3.2.19]
100622166	TRIP12; thyroid hormone receptor interactor 12 [KO:K10590] [EC:6.3.2.19]
100622318	E3 ubiquitin-protein ligase NEDD4-like; K10591 E3 ubiquitin-protein ligase NEDD4 [EC:6.3.2.19] [KO:K10591] [EC:6.3.2.19]
100154192	E3 ubiquitin-protein ligase NEDD4-like; K13305 E3 ubiquitin-protein ligase NEDD4-like [EC:6.3.2.19] [KO:K13305] [EC:6.3.2.19]
100512083	NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:6.3.2.19]
100517442	E3 ubiquitin-protein ligase HUWE1-like; K10592 E3 ubiquitin-protein ligase HUWE1 [EC:6.3.2.19] [KO:K10592] [EC:6.3.2.19]
100157625	UBR5; ubiquitin protein ligase E3 component n-recognin 5 [KO:K10593] [EC:6.3.2.19]
100738301	E3 ubiquitin-protein ligase UBR5-like; K10593 E3 ubiquitin-protein ligase EDD1 [EC:6.3.2.19] [KO:K10593] [EC:6.3.2.19]
100153537	HERC1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [KO:K10594] [EC:6.3.2.19]
100516114	E3 ubiquitin-protein ligase HERC2-like; K10595 E3 ubiquitin-protein ligase HERC2 [EC:6.3.2.19] [KO:K10595] [EC:6.3.2.19]
100517903	HERC3; HECT and RLD domain containing E3 ubiquitin protein ligase 3 [KO:K10614] [EC:6.3.2.19]
100513674	UBE4A; ubiquitination factor E4A [KO:K10596] [EC:6.3.2.19]
100521136	ubiquitin conjugation factor E4 B-like; K10597 ubiquitin conjugation factor E4 B [EC:6.3.2.19] [KO:K10597] [EC:6.3.2.19]
100511251	E3 ubiquitin-protein ligase CHIP-like; K09561 STIP1 homology and U-box containing protein 1 [EC:6.3.2.19] [KO:K09561] [EC:6.3.2.19]
100157972	PPIL2; peptidylprolyl isomerase (cyclophilin)-like 2 [KO:K10598] [EC:5.2.1.8]
100144769	PRPF19; PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) [KO:K10599] [EC:6.3.2.19]
100154685	UBOX5; U-box domain containing 5 [KO:K10600]
100125959	MDM2; Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) [KO:K06643] [EC:6.3.2.19]
100511697	CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C [KO:K04707] [EC:6.3.2.19]
100518854	CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase [KO:K04707] [EC:6.3.2.19]
100621690	CBLB; Cbl proto-oncogene, E3 ubiquitin protein ligase B [KO:K04707] [EC:6.3.2.19]
733673	PARK2; parkinson protein 2, E3 ubiquitin protein ligase (parkin) [KO:K04556] [EC:6.3.2.19]
100520614	E3 ubiquitin-protein ligase SIAH1-like; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
100737574	E3 ubiquitin-protein ligase SIAH1-like; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
100157336	PML; promyelocytic leukemia [KO:K10054]
396629	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
396617	MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
100520856	RFWD2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase [KO:K10143] [EC:6.3.2.19]
100038006	Pirh2; K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19] [KO:K10144] [EC:6.3.2.19]
100622859	BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
100622590	BIRC3; baculoviral IAP repeat containing 3 [KO:K16060]
100037300	XIAP; X-linked inhibitor of apoptosis [KO:K04725]
100519005	PIAS1; protein inhibitor of activated STAT, 1 [KO:K04706] [EC:6.3.2.-]
100627995	PIAS2; protein inhibitor of activated STAT, 2 [KO:K16063] [EC:6.3.2.-]
100511878	PIAS3; protein inhibitor of activated STAT, 3 [KO:K16064] [EC:6.3.2.-]
100624971	PIAS4; protein inhibitor of activated STAT, 4 [KO:K16065] [EC:6.3.2.-]
100514334	SYVN1; synovial apoptosis inhibitor 1, synoviolin [KO:K10601] [EC:6.3.2.19]
100152396	NHLRC1; NHL repeat containing 1 [KO:K10602] [EC:6.3.2.19]
100621659	autoimmune regulator-like; K10603 autoimmune regulator [KO:K10603]
100049682	MGRN1; mahogunin ring finger 1, E3 ubiquitin protein ligase [KO:K10604] [EC:6.3.2.19]
100049662	BRCA1; breast cancer 1, early onset [KO:K10605]
100526164	E3 ubiquitin-protein ligase FANCL-like; K10606 E3 ubiquitin-protein ligase FANCL [EC:6.3.2.19] [KO:K10606] [EC:6.3.2.19]
100524415	MID1; midline 1 (Opitz/BBB syndrome) [KO:K08285] [EC:6.3.2.19]
100737405	E3 ubiquitin-protein ligase TRIM32-like; K10607 tripartite motif-containing protein 32 [EC:6.3.2.19] [KO:K10607] [EC:6.3.2.19]
100518931	TRIM37; tripartite motif containing 37 [KO:K10608]
100524037	cullin-1-like; K03347 cullin 1 [KO:K03347]
100157842	BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
100329128	SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [KO:K03875]
100620112	FBXW7; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase [KO:K10260]
100511640	F-box only protein 2-like; K10099 F-box protein 2 [KO:K10099]
100522958	F-box only protein 4-like; K10291 F-box protein 4 [KO:K10291]
100512186	CUL2; cullin 2 [KO:K03870]
100153381	transcription elongation factor B polypeptide 1-like; K03872 transcription elongation factor B, polypeptide 1 [KO:K03872]
100519651	transcription elongation factor B polypeptide 2-like; K03873 transcription elongation factor B, polypeptide 2 [KO:K03873]
100739306	von Hippel-Lindau disease tumor suppressor-like; K03871 von Hippel-Lindau disease tumor supressor [KO:K03871]
100511787	cullin-3-like; K03869 cullin 3 [KO:K03869]
100136900	KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
100738260	kelch-like ECH-associated protein 1-like; K10456 kelch-like protein 19 [KO:K10456]
100739402	kelch-like protein 9-like; K10447 kelch-like protein 9/13 [KO:K10447]
100519287	kelch-like protein 13-like; K10447 kelch-like protein 9/13 [KO:K10447]
100158081	rho-related BTB domain-containing protein 2-like; K07868 Rho-related BTB domain-containing protein 1/2 [KO:K07868]
100153330	RHOBTB1; Rho-related BTB domain containing 1 [KO:K07868]
100155280	rho-related BTB domain-containing protein 2-like; K07868 Rho-related BTB domain-containing protein 1/2 [KO:K07868]
100152436	rho-related BTB domain-containing protein 2-like; K07868 Rho-related BTB domain-containing protein 1/2 [KO:K07868]
100513454	CUL4B; cullin 4B [KO:K10609]
100517912	CUL4A; cullin 4A [KO:K10609]
100522239	DNA damage-binding protein 1-like; K10610 DNA damage-binding protein 1 [KO:K10610]
100513197	DNA damage-binding protein 2-like; K10140 DNA damage-binding protein 2 [KO:K10140]
100524405	DNA excision repair protein ERCC-8-like; K10570 DNA excision repair protein ERCC-8 [KO:K10570]
100521834	DET1 homolog; K10571 de-etiolated-1 [KO:K10571]
100514874	RNF7; ring finger protein 7 [KO:K10611]
100525708	CUL5; cullin 5 [KO:K10612]
100307052	SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
493186	SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100141398	CUL7; cullin 7 [KO:K10613]
100156796	F-box/WD repeat-containing protein 8-like; K10264 F-box and WD-40 domain protein 8 [KO:K10264]
100620851	anaphase-promoting complex subunit 11-like; K03358 anaphase-promoting complex subunit 11 [KO:K03358]
397379	CDC20; cell division cycle 20 homolog (S. cerevisiae) [KO:K03363]
497234	FZR1; fizzy/cell division cycle 20 related 1 (Drosophila) [KO:K03364]
100519830	ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
100517185	cell division cycle protein 27 homolog; K03350 anaphase-promoting complex subunit 3 [KO:K03350]
100518619	ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
100152087	ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
100621739	CDC16; cell division cycle 16 homolog (S. cerevisiae) [KO:K03353]
100155743	ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
100515014	CDC23; cell division cycle 23 homolog (S. cerevisiae) [KO:K03355]
100415930	APC10; anaphase promoting complex subunit 10 protein [KO:K03357]
100621961	anaphase-promoting complex subunit CDC26-like; K03359 anaphase-promoting complex subunit 12 [KO:K03359]
100415776	ANAPC13; anaphase promoting complex subunit 13 [KO:K12456]

Reference

PMID:16922370 (Japanese)

Authors

Kamura T.

Title

[Cullin-based E3 family] Japanese

Journal

Tanpakushitsu Kakusan Koso 51:1167-72 (2006)

Reference

PMID:16922408 (Japanese)

Authors

Matsuda N.

Title

[Overview: hereditary disorders caused by dysfunction of ubiquitylation]

Journal

Tanpakushitsu Kakusan Koso 51:1402-7 (2006)

Reference

PMID:16922367 (Japanese)

Authors

Tokunaga F.

Title

[E2 ubiquitin-conjugating enzymes: structures and functions]

Journal

Tanpakushitsu Kakusan Koso 51:1150-6 (2006)

Reference

PMID:16816840

Authors

Nalepa G, Rolfe M, Harper JW.

Title

Drug discovery in the ubiquitin-proteasome system.

Journal

Nat Rev Drug Discov 5:596-613 (2006)

Reference

PMID:16405856

Authors

Hsu YJ, Goodman SR.

Title

Spectrin and ubiquitination: a review.

Journal

Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)

Reference

PMID:12944364

Authors

Hatakeyama S, Nakayama KI.

Title

Ubiquitylation as a quality control system for intracellular proteins.

Journal

J Biochem 134:1-8 (2003)

Reference

PMID:17588513

Authors

Lee J, Zhou P.

Title

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

Journal

Mol Cell 26:775-80 (2007)

KO pathway

ko04120

All links

Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (133)   
   KEGG GENES (133)   
All databases (136)   

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