KEGG PATHWAY: ssc05133

PATHWAY: ssc05133

Entry

ssc05133 Pathway

Name

Pertussis - Sus scrofa (pig)

Description

Pertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory wheezing and post-tussive vomiting.
Following the inhalation of respiratory secretions from an infected individual, bacteria enter the upper respiratory tract and adhere to epithelial cells. Several adhesion factors have been implicated: the filamentous hemagglutinin (FHA), fimbriae, and pertactin (Prn).
Pertussis toxin (Ptx) and adenylate cyclase toxin (ACT) have been identified so far as major protein toxins of B. pertussis. PTX is a hexameric AB5-type exotoxin. Catalytic A subunit catalyzes the ADP-ribosylation of the Gi subunits of the heterotrimeric G protein, then inhibits multiple downstream pathways. ACT is able to penetrate the cytoplasmic membrane of host cells and becomes activated through the cleavage and the binding of calmodulin (CaM). Activated ACT converts ATP to cyclic AMP and subverts cellular signaling pathways.

Class

Human Diseases; Infectious diseases

Pathway map

ssc05133

Pertussis

Module

ssc_M00574	Pertussis pathogenicity signature 1, pertussis toxin [PATH:ssc05133]
ssc_M00575	Pertussis pathogenicity signature 2, T1SS [PATH:ssc05133]

Organism

Sus scrofa (pig) [GN:ssc]

Gene

100155091	ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [KO:K06484]
397019	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
397459	ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) [KO:K06461]
396943	ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
100154056	CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
100516639	calmodulin-like; K02183 calmodulin [KO:K02183]
396838	CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
100522926	calmodulin-like; K02183 calmodulin [KO:K02183]
100738118	calmodulin-like; K02183 calmodulin [KO:K02183]
396849	RHOA; ras homolog family member A [KO:K04513]
445532	COFILIN; COFILIN protein [KO:K05765]
497233	CFL2; cofilin 2 (muscle) [KO:K05765]
397244	CASP3; caspase 3, apoptosis-related cysteine peptidase [KO:K02187] [EC:3.4.22.56]
397319	CASP1; caspase 1, apoptosis-related cysteine peptidase [KO:K01370] [EC:3.4.22.36]
100522011	apoptosis-associated speck-like protein containing a CARD-like; K12799 apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100514823	NLRP3; NLR family, pyrin domain containing 3 [KO:K12800]
396565	IL-1beta; interleukin-1 beta [KO:K04519]
397122	IL1B; interleukin 1, beta [KO:K04519]
445461	C1QA; complement component 1, q subcomponent, A chain [KO:K03986]
100518846	C1QB; complement component 1, q subcomponent, B chain [KO:K03987]
100739136	complement C1q subcomponent subunit B-like; K03987 complement C1q subcomponent subunit B [KO:K03987]
445460	C1QC; complement component 1, q subcomponent, C chain [KO:K03988]
445464	C1R; complement component 1, r subcomponent [KO:K01330] [EC:3.4.21.41]
397274	C1S; complement component 1, s subcomponent [KO:K01331] [EC:3.4.21.42]
448981	C2; complement component 2 [KO:K01332] [EC:3.4.21.43]
445467	C4; complement C4 [KO:K03989]
397072	C3; complement component 3 [KO:K03990]
414437	C5; complement component 5 [KO:K03994]
100144304	SERPING1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 [KO:K04001]
100520761	C4b-binding protein alpha chain-like; K04002 complement component 4 binding protein, alpha [KO:K04002]
396982	C4BPA; complement component 4 binding protein, alpha [KO:K04002]
100520583	C4b-binding protein beta chain-like; K04003 complement component 4 binding protein, beta [KO:K04003]
100125555	LY96; lymphocyte antigen 96 [KO:K05400]
399541	TLR4; toll-like receptor 4 [KO:K10160]
100037938	CD14; CD14 molecule [KO:K04391]
100514174	toll/interleukin-1 receptor domain-containing adapter protein-like; K05403 toll-interleukin 1 receptor (TIR) domain-containing adaptor protein [KO:K05403]
396646	MYD88; myeloid differentiation primary response gene (88) [KO:K04729]
100127166	IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
396606	IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
396629	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
751869	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
100135665	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
100520421	TICAM2; toll-like receptor adaptor molecule 2 [KO:K05409]
100623776	TIR domain-containing adapter molecule 1-like; K05842 toll-like receptor adapter molecule 1 [KO:K05842]
396656	IRF3; interferon regulatory factor 3 [KO:K05411]
574062	MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100156630	MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
396610	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100521736	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
396609	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100153927	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
445013	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100144486	FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
396913	C-JUN; C-JUN protein [KO:K04448]
399500	IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
100628202	IL-6; interleukin-6 [KO:K05405]
397053	IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
397076	IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
100155546	IL23A; interleukin 23, alpha subunit p19 [KO:K05426]
397086	TNF; tumor necrosis factor [KO:K03156]
397106	IL10; interleukin 10 [KO:K05443]
396611	IRF1; interferon regulatory factor 1 [KO:K09444]
396645	IRF8; interferon regulatory factor 8 [KO:K10155]
397503	SFTPA1; surfactant protein A1 [KO:K10067]
100144421	GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
100144419	GBI1; GBI1 protein [KO:K04630]
397523	GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
396880	IL8; interleukin 8 [KO:K10030]
100620730	interleukin-8-like; K10030 interleukin 8 [KO:K10030]
396900	AMCF-II; alveolar macrophage-derived chemotactic factor-II [KO:K05506]
100135660	NOD1; nucleotide-binding oligomerization domain containing 1 [KO:K08727]
397094	IL1A; interleukin 1, alpha [KO:K04383]
396859	NOS2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]

Compound

C00002	ATP
C00076	Calcium cation
C00238	Potassium cation
C00253	Nicotinate
C00338	Lipopolysaccharide
C00374	Heparin
C00575	3',5'-Cyclic AMP
C05005	Glycolipid
C12505	Magnesium sulfate
C19596	Lipooligosaccharide

Reference

PMID:21204863

Authors

de Gouw D, Diavatopoulos DA, Bootsma HJ, Hermans PW, Mooi FR

Title

Pertussis: a matter of immune modulation.

Journal

FEMS Microbiol Rev 35:441-74 (2011)

Reference

PMID:20210554

Authors

Carbonetti NH

Title

Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.

Journal

Future Microbiol 5:455-69 (2010)

Reference

PMID:10540218

Authors

van den Berg BM, van Furth R, Hazenbos WL

Title

Activation of complement receptor 3 on human monocytes by cross-linking of very-late antigen-5 is mediated via protein tyrosine kinases.

Journal

Immunology 98:197-202 (1999)

Reference

PMID:16999837

Authors

Mazar J, Cotter PA

Title

Topology and maturation of filamentous haemagglutinin suggest a new model for two-partner secretion.

Journal

Mol Microbiol 62:641-54 (2006)

Reference

PMID:16390441

Authors

Hewlett EL, Donato GM, Gray MC

Title

Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!

Journal

Mol Microbiol 59:447-59 (2006)

Reference

PMID:20610650

Authors

Dunne A, Ross PJ, Pospisilova E, Masin J, Meaney A, Sutton CE, Iwakura Y, Tschopp J, Sebo P, Mills KH

Title

Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.

Journal

J Immunol 185:1711-9 (2010)

Reference

PMID:18401006

Authors

Hickey FB, Brereton CF, Mills KH

Title

Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells.

Journal

J Leukoc Biol 84:234-43 (2008)

Reference

PMID:16622221

Authors

Spensieri F, Fedele G, Fazio C, Nasso M, Stefanelli P, Mastrantonio P, Ausiello CM

Title

Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.

Journal

Infect Immun 74:2831-8 (2006)

Reference

PMID:17148436

Authors

Fiser R, Masin J, Basler M, Krusek J, Spulakova V, Konopasek I, Sebo P

Title

Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities.

Journal

J Biol Chem 282:2808-20 (2007)

Reference

PMID:16863919

Authors

Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ

Title

Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.

Journal

Exp Hematol 34:1115-24 (2006)

Reference

PMID:15201703

Authors

Fan H, Peck OM, Tempel GE, Halushka PV, Cook JA

Title

Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation.

Journal

Shock 22:57-62 (2004)

Reference

PMID:17328678

Authors

Lee MS, Kim YJ

Title

Signaling pathways downstream of pattern-recognition receptors and their cross talk.

Journal

Annu Rev Biochem 76:447-80 (2007)

Reference

PMID:20404851

Authors

Kawai T, Akira S

Title

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.

Journal

Nat Immunol 11:373-84 (2010)

Reference

PMID:12701623

Authors

Ferlito M, Romanenko OG, Guyton K, Ashton S, Squadrito F, Halushka PV, Cook JA

Title

Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production.

Journal

J Endotoxin Res 8:427-35 (2002)

Reference

PMID:21423776

Authors

Han HJ, Kuwae A, Abe A, Arakawa Y, Kamachi K

Title

Differential expression of type III effector BteA protein due to IS481 insertion in Bordetella pertussis.

Journal

PLoS One 6:e17797 (2011)

Reference

PMID:16481212

Authors

Beier D, Gross R

Title

Regulation of bacterial virulence by two-component systems.

Journal

Curr Opin Microbiol 9:143-52 (2006)

Reference

PMID:12915094

Authors

Cotter PA, Jones AM

Title

Phosphorelay control of virulence gene expression in Bordetella.

Journal

Trends Microbiol 11:367-73 (2003)

KO pathway

ko05133

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Genome (1)   
   KEGG GENOME (1)   
Gene (73)   
   KEGG GENES (73)   
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