KEGG   PATHWAY: ssc05166Help
Entry
ssc05166                    Pathway                                
Name
HTLV-I infection - Sus scrofa (pig)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
ssc05166

All organismsOrtholog table
Organism
Sus scrofa (pig) [GN:ssc]
Gene
397078  
TGFB1; transforming growth factor, beta 1 [KO:K13375]
397084  
TGFB2; transforming growth factor, beta 2 [KO:K13376]
397400  
TGFB3; transforming growth factor, beta 3 [KO:K13377]
397404  
SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
NRP1; neuropilin 1 [KO:K06724]
396925  
VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
396661  
CD3D; CD3d molecule, delta (CD3-TCR complex) [KO:K06450]
397455  
CD3E; CD3e molecule, epsilon (CD3-TCR complex) [KO:K06451]
494013  
CD3G; CD3g molecule, gamma (CD3-TCR complex) [KO:K06452]
396750  
ICAM-1; intercellular adhesion molecule-1 [KO:K06490]
733681  
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
396943  
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
TLN2; talin 2 [KO:K06271]
TLN1; talin 1 [KO:K06271]
448810  
MYC; v-myc myelocytomatosis viral oncogene homolog (avian) [KO:K04377]
TRRAP; transformation/transcription domain-associated protein [KO:K08874]
KAT5; K(lysine) acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
397162  
CCND2; cyclin D2 [KO:K10151]
RANBP3; RAN binding protein 3 [KO:K15304]
397655  
RAN; RAN, member RAS oncogene family [KO:K07936]
397330  
XPO1; exportin 1 (CRM1 homolog, yeast) [KO:K14290]
396650  
SLA-7; MHC class I antigen 7 [KO:K06751]
SLA-2; MHC class I antigen 2 [KO:K06751]
SLA-3; MHC class I antigen 3 [KO:K06751]
SLA-1; MHC class I antigen 1 [KO:K06751]
SLA-5; MHC class I antigen 5 [KO:K06751]
SLA-8; MHC class I antigen 8 [KO:K06751]
SLA-6; MHC class I antigen 6 [KO:K06751]
class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
CALR; calreticulin [KO:K08057]
397241  
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
396603  
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
calcineurin subunit B type 2-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcium-binding protein p22-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcineurin subunit B type 1-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcium-binding protein p22-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcineurin subunit B type 2-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcineurin subunit B type 1-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
397318  
NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
NFAT5; nuclear factor of activated T-cells 5, tonicity-responsive [KO:K04446]
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K04446]
NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K04446]
NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K04446]
CANX; calnexin [KO:K08054]
interleukin-2 receptor subunit beta-like; K05069 interleukin 2 receptor beta [KO:K05069]
397156  
IL2RG; interleukin 2 receptor, gamma [KO:K05070]
397202  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
397550  
STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
397340  
STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
FDPS; farnesyl diphosphate synthase [KO:K00787] [EC:2.5.1.10 2.5.1.1]
GTPase KRas-like; K07827 GTPase KRas [KO:K07827]
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
ras-related protein R-Ras-like; K07829 Ras-related protein R-Ras [KO:K07829]
ras-related protein M-Ras-like; K07831 Ras-related protein M-Ras [KO:K07831]
397010  
VDAC1; voltage-dependent anion channel 1 [KO:K05862]
403155  
SLC25A6; solute carrier family 25 (mitochondrial carrier [KO:K05863]
adenine nucleotide translocator 2; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
ADP/ATP translocase 1-like; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
ADP/ATP translocase 4-like; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
397659  
VDAC2; voltage-dependent anion channel 2 [KO:K15040]
voltage-dependent anion-selective channel protein 3-like; K15041 voltage-dependent anion channel protein 3 [KO:K15041]
397651  
VDAC1P5; voltage-dependent anion channel 1 pseudogene 5 [KO:K15041]
396592  
TSPO; translocator protein (18kDa) [KO:K05770]
VAC14; Vac14 homolog (S. cerevisiae) [KO:K15305]
RANBP1; RAN binding protein 1 [KO:K15306]
mitotic spindle assembly checkpoint protein MAD2A-like; K02537 mitotic spindle assembly checkpoint protein MAD2 [KO:K02537]
mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like; K06637 mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1] [KO:K06637] [EC:2.7.11.1]
BUB3; budding uninhibited by benzimidazoles 3 homolog (yeast) [KO:K02180]
397379  
CDC20; cell division cycle 20 homolog (S. cerevisiae) [KO:K03363]
ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
cell division cycle protein 27 homolog; K03350 anaphase-promoting complex subunit 3 [KO:K03350]
ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
CDC16; cell division cycle 16 homolog (S. cerevisiae) [KO:K03353]
ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
CDC23; cell division cycle 23 homolog (S. cerevisiae) [KO:K03355]
APC10; anaphase promoting complex subunit 10 protein [KO:K03357]
anaphase-promoting complex subunit 11-like; K03358 anaphase-promoting complex subunit 11 [KO:K03358]
anaphase-promoting complex subunit CDC26-like; K03359 anaphase-promoting complex subunit 12 [KO:K03359]
397015  
PTTG1; pituitary tumor-transforming 1 [KO:K06635]
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
cyclin-dependent kinase inhibitor 1-like; K06625 cyclin-dependent kinase inhibitor 1A [KO:K06625]
692192  
PCNA; proliferating cell nuclear antigen [KO:K04802]
POLD1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
POLD2; polymerase (DNA directed), delta 2, accessory subunit [KO:K02328]
DNA polymerase delta subunit 3-like; K03504 DNA polymerase delta subunit 3 [KO:K03504]
POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
DNA polymerase delta subunit 4-like; K03505 DNA polymerase delta subunit 4 [KO:K03505]
POLE; polymerase (DNA directed), epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
DNA polymerase epsilon subunit 2-like; K02325 DNA polymerase epsilon subunit 2 [EC:2.7.7.7] [KO:K02325] [EC:2.7.7.7]
DNA polymerase epsilon subunit 3-like; K02326 DNA polymerase epsilon subunit 3 [EC:2.7.7.7] [KO:K02326] [EC:2.7.7.7]
DNA polymerase epsilon subunit 4-like; K03506 DNA polymerase epsilon subunit 4 [EC:2.7.7.7] [KO:K03506] [EC:2.7.7.7]
uncharacterized LOC100738589; K04503 cyclin D1 [KO:K04503]
780426  
CCND3; cyclin D3 [KO:K10152]
CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
RB1; retinoblastoma 1 [KO:K06618]
transcription factor E2F1-like; K06620 E2F transcription factor 1/3 [KO:K06620]
transcription factor E2F3-like; K06620 E2F transcription factor 1/3 [KO:K06620]
397227  
CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO:K04685]
WNT1; wingless-type MMTV integration site family, member 1 [KO:K03209]
protein Wnt-2-like; K00182 wingless-type MMTV integration site family, member 2 [KO:K00182]
WNT2B; wingless-type MMTV integration site family, member 2B [KO:K00182]
protein Wnt-3a-like; K00312 wingless-type MMTV integration site family, member 3 [KO:K00312]
WNT4; wingless-type MMTV integration site family, member 4 [KO:K00408]
protein Wnt-5b-like; K00444 wingless-type MMTV integration site family, member 5 [KO:K00444]
protein Wnt-5a-like; K00444 wingless-type MMTV integration site family, member 5 [KO:K00444]
protein Wnt-6-like; K00445 wingless-type MMTV integration site family, member 6 [KO:K00445]
protein Wnt-7a-like; K00572 wingless-type MMTV integration site family, member 7 [KO:K00572]
uncharacterized LOC100626947; K00572 wingless-type MMTV integration site family, member 7 [KO:K00572]
WNT8B; wingless-type MMTV integration site family, member 8B [KO:K00714]
WNT8A; wingless-type MMTV integration site family, member 8A [KO:K00714]
WNT9A; wingless-type MMTV integration site family, member 9A [KO:K01064]
protein Wnt-9b-like; K01064 wingless-type MMTV integration site family, member 9 [KO:K01064]
protein Wnt-9b-like; K01064 wingless-type MMTV integration site family, member 9 [KO:K01064]
WNT10B; wingless-type MMTV integration site family, member 10B [KO:K01357]
WNT11; wingless-type MMTV integration site family, member 11 [KO:K01384]
protein Wnt-11-like; K01384 wingless-type MMTV integration site family, member 11 [KO:K01384]
protein Wnt-16-like; K01558 wingless-type MMTV integration site family, member 16 [KO:K01558]
frizzled-7-like; K02432 frizzled 1/7 [KO:K02432]
FZD2; frizzled family receptor 2 [KO:K02235]
FZD3; frizzled family receptor 3 [KO:K02329]
FZD4; frizzled family receptor 4 [KO:K02354]
frizzled-5-like; K02375 frizzled 5/8 [KO:K02375]
frizzled-6-like; K02376 frizzled 6 [KO:K02376]
frizzled-10-like; K02842 frizzled 9/10 [KO:K02842]
frizzled-9-like; K02842 frizzled 9/10 [KO:K02842]
segment polarity protein dishevelled homolog DVL-1-like; K02353 segment polarity protein dishevelled [KO:K02353]
DVL3; dishevelled, dsh homolog 3 (Drosophila) [KO:K02353]
DVL2; dishevelled, dsh homolog 2 (Drosophila) [KO:K02353]
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
397657  
CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
APC; adenomatous polyposis coli [KO:K02085]
APC2; adenomatosis polyposis coli 2 [KO:K02085]
DLG1; discs, large homolog 1 (Drosophila) [KO:K12076]
platelet-derived growth factor subunit A-like; K04359 platelet derived growth factor A/B [KO:K04359]
uncharacterized LOC100626465; K04359 platelet derived growth factor A/B [KO:K04359]
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
396851  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit alpha-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit beta-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit alpha-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
396979  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
397086  
TNF; tumor necrosis factor [KO:K03156]
397020  
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
396617  
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
dual specificity mitogen-activated protein kinase kinase 4-like; K04430 mitogen-activated protein kinase kinase 4 [EC:2.7.12.2] [KO:K04430] [EC:2.7.12.2]
396610  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
396609  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
396913  
C-JUN; C-JUN protein [KO:K04448]
GPS2; G protein pathway suppressor 2 [KO:K15307]
interleukin-1 receptor type 1-like; K04386 interleukin 1 receptor type I [KO:K04386]
interleukin-1 receptor type 2-like; K04387 interleukin 1 receptor type II [KO:K04387]
IL1R2; interleukin 1 receptor, type II [KO:K04387]
uncharacterized LOC100626606; K10784 T cell receptor alpha chain V region [KO:K10784]
uncharacterized LOC100620407; K10784 T cell receptor alpha chain V region [KO:K10784]
T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
406188  
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
751869  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
tumor necrosis factor receptor superfamily member 3-like; K03159 lymphotoxin beta receptor TNFR superfamily member 3 [KO:K03159]
397395  
CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
RELB; v-rel reticuloendotheliosis viral oncogene homolog B [KO:K09253]
NFKB2_tv2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 [KO:K04469]
396868  
IL2; interleukin 2 [KO:K05429]
396814  
IL2RA; interleukin 2 receptor, alpha [KO:K05068]
397683  
IL15; interleukin 15 [KO:K05433]
733692  
IL15RA; interleukin 15 receptor, alpha [KO:K05074]
399500  
IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
IL-6; interleukin-6 [KO:K05405]
397208  
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
407742  
LTA; lymphotoxin alpha (TNF superfamily, member 1) [KO:K05468]
397536  
BCL2L1; BCL2-like 1 [KO:K04570]
XIAP; X-linked inhibitor of apoptosis [KO:K04725]
ZFP36; zinc finger protein 36, C3H type, homolog (mouse) [KO:K15308]
tristetraprolin-like; K15308 tristetraprolin [KO:K15308]
NFYB; nuclear transcription factor Y, beta [KO:K08065]
445528  
SLA-DMA; SLA-DM alpha chain [KO:K06752]
SLA-DRA; MHC class II DR-alpha [KO:K06752]
SLA-DOB; MHC class II, DO beta [KO:K06752]
SLA-DMB; MHC class II, DM beta [KO:K06752]
SLA-DQB1; SLA-DQ beta1 domain [KO:K06752]
SLA-DQA1; MHC class II histocompatibility antigen SLA-DQA [KO:K06752]
SLA-DRB1; MHC class II histocompatibility antigen SLA-DRB1 [KO:K06752]
SLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
SRF; serum response factor (c-fos serum response element-binding transcription factor) [KO:K04378]
ELK4; ELK4, ETS-domain protein (SRF accessory protein 1) [KO:K04376]
ELK1; ELK1, member of ETS oncogene family [KO:K04375]
414912  
SPI1; spleen focus forming virus (SFFV) proviral integration oncogene spi1 [KO:K09438]
v-ets erythroblastosis virus E26 oncogene homolog 2; K02678 c-ets proto-oncogene protein [KO:K02678]
ETS1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [KO:K02678]
TATA box-binding protein-like protein 2-like; K03120 transcription initiation factor TFIID TATA-box-binding protein [KO:K03120]
TATA box-binding protein-like protein 1-like; K03120 transcription initiation factor TFIID TATA-box-binding protein [KO:K03120]
TATA box binding protein; K03120 transcription initiation factor TFIID TATA-box-binding protein [KO:K03120]
FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
EGR1; early growth response 1 [KO:K09203]
EGR2; early growth response 2 [KO:K12496]
fos-related antigen 1-like; K04502 fos-like antigen 1 [KO:K04502]
adenylate cyclase type 1-like; K08041 adenylate cyclase 1 [EC:4.6.1.1] [KO:K08041] [EC:4.6.1.1]
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
ADCY8; adenylate cyclase 8 (brain) [KO:K08043] [EC:4.6.1.1]
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
adenylate cyclase type 7-like; K08047 adenylate cyclase 7 [EC:4.6.1.1] [KO:K08047] [EC:4.6.1.1]
adenylate cyclase type 8-like; K08048 adenylate cyclase 8 [EC:4.6.1.1] [KO:K08048] [EC:4.6.1.1]
adenylate cyclase type 8-like; K08048 adenylate cyclase 8 [EC:4.6.1.1] [KO:K08048] [EC:4.6.1.1]
adenylate cyclase type 8-like; K08048 adenylate cyclase 8 [EC:4.6.1.1] [KO:K08048] [EC:4.6.1.1]
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
397652  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
serine/threonine-protein kinase PRKX-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
397449  
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
cAMP-responsive element modulator-like; K09052 cAMP response element modulator [KO:K09052]
ATF2; activating transcription factor 2 [KO:K04450]
cyclic AMP-dependent transcription factor ATF-3-like; K09032 activating transcription factor 3 [KO:K09032]
ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) [KO:K04374]
XBP1; X-box binding protein 1 [KO:K09027]
CRTC1; CREB regulated transcription coactivator 1 [KO:K15309]
CREB-regulated transcription coactivator 2-like; K16333 CREB-regulated transcription coactivator 2 [KO:K16333]
CREB-regulated transcription coactivator 3-like; K16334 CREB-regulated transcription coactivator 3 [KO:K16334]
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
KAT2A; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
KAT2B; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
DNA polymerase beta-like; K02330 DNA polymerase beta [EC:2.7.7.7 4.2.99.-] [KO:K02330] [EC:4.2.99.- 2.7.7.7]
cyclin-dependent kinase 4 inhibitor C-like; K06622 cyclin-dependent kinase inhibitor 2C [KO:K06622]
LCK; lymphocyte-specific protein tyrosine kinase [KO:K05856] [EC:2.7.10.2]
492280  
TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
MYB; v-myb myeloblastosis viral oncogene homolog (avian) [KO:K09420]
MYBL1; v-myb myeloblastosis viral oncogene homolog (avian)-like 1 [KO:K09421]
MYBL2; v-myb myeloblastosis viral oncogene homolog (avian)-like 2 [KO:K09421]
396665  
TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
transforming growth factor beta receptor II; K04388 TGF-beta receptor type-2 [EC:2.7.11.30] [KO:K04388] [EC:2.7.11.30]
397260  
SMAD3; SMAD family member 3 [KO:K04500]
SMAD2; SMAD family member 2 [KO:K04500]
397142  
SMAD4; SMAD family member 4 [KO:K04501]
ATM; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
serine/threonine-protein kinase ATR-like; K06640 serine/threonine-protein kinase ATR [EC:2.7.11.1] [KO:K06640] [EC:2.7.11.1]
CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
397276  
TP53; tumor protein p53 [KO:K04451]
396633  
BAX; BCL2-associated X protein [KO:K02159]
tumor protein p53-inducible nuclear protein 1-like; K15310 tumor protein p53-inducible nuclear protein 1 [KO:K15310]
MSX1; msh homeobox 1 [KO:K09341]
homeobox protein MSX-3-like; K09341 homeobox protein MSX [KO:K09341]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
Reference
  Authors
Yasunaga J, Matsuoka M
  Title
[HTLV-I and leukemogenesis].
  Journal
Uirusu 56:241-9 (2006)
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
Reference
  Authors
Peloponese JM Jr, Jeang KT
  Title
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.
  Journal
J Biol Chem 281:8927-38 (2006)
Reference
  Authors
Marriott SJ, Semmes OJ
  Title
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.
  Journal
Oncogene 24:5986-95 (2005)
Reference
  Authors
Jeang KT
  Title
Functional activities of the human T-cell leukemia virus type I Tax oncoprotein:  cellular signaling through NF-kappa B.
  Journal
Cytokine Growth Factor Rev 12:207-17 (2001)
Reference
  Authors
Bouzar AB, Willems L
  Title
How HTLV-1 may subvert miRNAs for persistence and transformation.
  Journal
Retrovirology 5:101 (2008)
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
Reference
  Authors
Manel N, Battini JL, Taylor N, Sitbon M
  Title
HTLV-1 tropism and envelope receptor.
  Journal
Oncogene 24:6016-25 (2005)
Reference
  Authors
Sun SC, Ballard DW
  Title
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
  Journal
Oncogene 18:6948-58 (1999)
Reference
  Authors
Taylor GP, Matsuoka M
  Title
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy.
  Journal
Oncogene 24:6047-57 (2005)
Reference
  Authors
Franchini G, Fukumoto R, Fullen JR
  Title
T-cell control by human T-cell leukemia/lymphoma virus type 1.
  Journal
Int J Hematol 78:280-96 (2003)
Reference
  Authors
Baydoun HH, Bellon M, Nicot C
  Title
HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.
  Journal
AIDS Rev 10:195-204 (2008)
Reference
PMID:9325311
  Authors
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT
  Title
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
  Journal
J Biol Chem 272:25816-23 (1997)
Reference
  Authors
Pise-Masison CA, Brady JN
  Title
Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.
  Journal
Front Biosci 10:919-30 (2005)
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