KEGG   PATHWAY: ssc05166Help
Entry
ssc05166                    Pathway                                

Name
HTLV-I infection - Sus scrofa (pig)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
ssc05166

All organismsOrtholog table
Organism
Sus scrofa (pig) [GN:ssc]
Gene
397078  
TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
397084  
TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
397400  
TGFB3; transforming growth factor beta-3 precursor [KO:K13377]
NRP1; neuropilin-1 isoform X2 [KO:K06724]
396925  
VCAM1; vascular cell adhesion protein 1 precursor [KO:K06527]
396661  
CD3D; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
397455  
CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
494013  
CD3G; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
396750  
ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
733681  
ITGAL; integrin alpha-L precursor [KO:K05718]
396943  
ITGB2; integrin beta-2 precursor [KO:K06464]
TLN2; talin-2 isoform X1 [KO:K06271]
TLN1; talin-1 isoform X1 [KO:K06271]
448810  
MYC; myc proto-oncogene protein [KO:K04377]
KAT5; histone acetyltransferase KAT5 [KO:K11304] [EC:2.3.1.48]
397162  
CCND2; G1/S-specific cyclin-D2 [KO:K10151]
RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
397655  
RAN; GTP-binding nuclear protein Ran [KO:K07936]
397330  
XPO1; exportin-1 isoform X3 [KO:K14290]
396650  
SLA-7; MHC class I antigen 7 precursor [KO:K06751]
SLA-2; MHC class I antigen 2 precursor [KO:K06751]
SLA-3; MHC class I antigen 3 precursor [KO:K06751]
SLA-1; MHC class I antigen 1 isoform X2 [KO:K06751]
SLA-5; MHC class I antigen 5 precursor [KO:K06751]
SLA-8; MHC class I antigen 8 precursor [KO:K06751]
SLA-6; MHC class I antigen 6 precursor [KO:K06751]
TRIM52; tripartite motif-containing protein 52 isoform X4 [KO:K06751]
CALR; calreticulin precursor [KO:K08057]
397241  
PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
396603  
PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
PPP3R2; calcineurin subunit B type 2 [KO:K06268]
PPP3R1; calcineurin subunit B type 1 [KO:K06268]
397318  
NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
CANX; calnexin precursor [KO:K08054]
IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
397156  
IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
397202  
JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
397550  
STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
397340  
STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
FDPS; farnesyl pyrophosphate synthase precursor [KO:K00787] [EC:2.5.1.10 2.5.1.1]
KRAS; GTPase KRas isoform X2 [KO:K07827]
NRAS; GTPase NRas precursor [KO:K07828]
RRAS; ras-related protein R-Ras [KO:K07829]
LOW QUALITY PROTEIN: ras-related protein R-Ras2 [KO:K07830]
MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
397010  
VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
403155  
SLC25A6; ADP/ATP translocase 3 [KO:K05863]
SLC25A5; ADP/ATP translocase 2 [KO:K05863]
SLC25A4; ADP/ATP translocase 1 [KO:K05863]
SLC25A31; ADP/ATP translocase 4 [KO:K05863]
397659  
VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
397651  
VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
396592  
TSPO; translocator protein [KO:K05770]
VAC14; protein VAC14 homolog [KO:K15305]
RANBP1; ran-specific GTPase-activating protein [KO:K15306]
MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
BUB3; mitotic checkpoint protein BUB3 isoform X2 [KO:K02180]
397379  
CDC20; cell division cycle protein 20 homolog [KO:K03363]
ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
CDC16; cell division cycle protein 16 homolog [KO:K03353]
ANAPC7; anaphase-promoting complex subunit 7 isoform X2 [KO:K03354]
CDC23; cell division cycle protein 23 homolog [KO:K03355]
ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
397015  
PTTG1; securin isoform X1 [KO:K06635]
CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
692192  
PCNA; proliferating cell nuclear antigen [KO:K04802]
POLD1; DNA polymerase delta catalytic subunit isoform X2 [KO:K02327] [EC:2.7.7.7]
POLD2; DNA polymerase delta subunit 2 [KO:K02328]
POLD3; DNA polymerase delta subunit 3 [KO:K03504]
POLD4; DNA polymerase delta subunit 4 [KO:K03505]
POLE; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
POLE2; DNA polymerase epsilon subunit 2 isoform X1 [KO:K02325] [EC:2.7.7.7]
POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
POLE4; DNA polymerase epsilon subunit 4 isoform X1 [KO:K03506] [EC:2.7.7.7]
CCND1; G1/S-specific cyclin-D1 [KO:K04503]
780426  
CCND3; G1/S-specific cyclin-D3 [KO:K10152]
CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
RB1; retinoblastoma-associated protein [KO:K06618]
E2F1; transcription factor E2F1 [KO:K17454]
E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
397227  
CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
WNT1; proto-oncogene Wnt-1 [KO:K03209]
WNT2; protein Wnt-2 [KO:K00182]
WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
WNT4; protein Wnt-4 [KO:K00408]
WNT5B; LOW QUALITY PROTEIN: protein Wnt-5b [KO:K00444]
WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
WNT6; protein Wnt-6 [KO:K00445]
WNT7A; protein Wnt-7a [KO:K00572]
WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
WNT8A; protein Wnt-8a [KO:K00714]
WNT9A; protein Wnt-9a [KO:K01064]
WNT9B; protein Wnt-9b [KO:K01064]
WNT10B; protein Wnt-10b precursor [KO:K01357]
WNT11; protein Wnt-11 [KO:K01384]
WNT16; protein Wnt-16 [KO:K01558]
FZD7; frizzled-7 [KO:K02432]
FZD2; frizzled-2 precursor [KO:K02235]
FZD3; frizzled-3 isoform X1 [KO:K02329]
FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
FZD5; frizzled-5 [KO:K02375]
FZD6; frizzled-6 precursor [KO:K02376]
FZD10; frizzled-10 [KO:K02842]
FZD9; frizzled-9 [KO:K02842]
DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
397657  
CTNNB1; catenin beta-1 [KO:K02105]
APC; adenomatous polyposis coli protein [KO:K02085]
APC2; adenomatous polyposis coli protein 2 [KO:K02085]
DLG1; disks large homolog 1 isoform X14 [KO:K12076]
PDGFA; platelet-derived growth factor subunit A isoform X5 [KO:K04359]
PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
397086  
TNF; tumor necrosis factor [KO:K03156]
397020  
TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
396617  
MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
396913  
JUN; transcription factor AP-1 [KO:K04448]
GPS2; G protein pathway suppressor 2 [KO:K15307]
IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
IL1R2; interleukin-1 receptor type 2 precursor [KO:K04387]
uncharacterized protein LOC100626606 [KO:K10784]
T-cell receptor beta-1 chain C region [KO:K10785]
MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
IKBKG; NF-kappa-B essential modulator [KO:K07210]
406188  
NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
751869  
NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
RELA; transcription factor p65 [KO:K04735]
LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
397395  
CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
RELB; transcription factor RelB isoform X1 [KO:K09253]
NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
396868  
IL2; interleukin-2 precursor [KO:K05429]
396814  
IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
397683  
IL15; interleukin-15 precursor [KO:K05433]
733692  
IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074]
399500  
IL6; interleukin-6 precursor [KO:K05405]
397208  
CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
407742  
LTA; lymphotoxin-alpha precursor [KO:K05468]
397536  
BCL2L1; bcl-2-like protein 1 [KO:K04570]
XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
ZFP36; tristetraprolin [KO:K15308]
NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
445528  
SLA-DMA; SLA-DM alpha chain precursor [KO:K06752]
SLA-DRA; MHC class II DR-alpha precursor [KO:K06752]
SLA-DOB; MHC class II, DO beta precursor [KO:K06752]
SLA-DMB; MHC class II, DM beta precursor [KO:K06752]
SLA-DQB1; SLA class II histocompatibility antigen, DQ haplotype C beta chain precursor [KO:K06752]
SLA-DQA1; SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor [KO:K06752]
SLA-DRB1; MHC class II histocompatibility antigen SLA-DRB1 precursor [KO:K06752]
SLA-DOA; SLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
DLA class II histocompatibility antigen, DR-1 beta chain-like precursor [KO:K06752]
SRF; serum response factor [KO:K04378]
ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
414912  
SPI1; transcription factor PU.1 [KO:K09438]
ETS1; protein C-ets-1 [KO:K02678]
ETS2; protein C-ets-2 [KO:K21932]
TBPL2; TATA box-binding protein-like protein 2 isoform X6 [KO:K03120]
TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
TATA-box-binding protein [KO:K03120]
FOS; proto-oncogene c-Fos [KO:K04379]
EGR1; early growth response protein 1 [KO:K09203]
EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
FOSL1; fos-related antigen 1 [KO:K04502]
ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
ADCY6; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
397652  
PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
CREM; cAMP-responsive element modulator isoform X11 [KO:K09052]
ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
ATF3; cyclic AMP-dependent transcription factor ATF-3 isoform X1 [KO:K09032]
ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
XBP1; X-box-binding protein 1 isoform XBP1(U) [KO:K09027]
CRTC1; LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 1 [KO:K15309]
CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
KAT2A; histone acetyltransferase KAT2A isoform X4 [KO:K06062] [EC:2.3.1.48]
KAT2B; LOW QUALITY PROTEIN: histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
POLB; LOW QUALITY PROTEIN: DNA polymerase beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
492280  
TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
MYB; LOW QUALITY PROTEIN: transcriptional activator Myb [KO:K09420]
MYBL2; myb-related protein B [KO:K21769]
396665  
TGFBR1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
397260  
SMAD3; mothers against decapentaplegic homolog 3 [KO:K04500]
SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
397142  
SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
397276  
TP53; cellular tumor antigen p53 [KO:K04451]
396633  
BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
TP53INP1; tumor protein p53-inducible nuclear protein 1 isoform X1 [KO:K15310]
MSX1; homeobox protein MSX-1 [KO:K09341]
VENTX; homeobox protein VENTX isoform X2 [KO:K09341]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
DOI:10.1038/sj.onc.1206549
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
DOI:10.1038/sj.bjc.6605345
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
  Authors
Yasunaga J, Matsuoka M
  Title
[HTLV-I and leukemogenesis].
  Journal
Uirusu 56:241-9 (2006)
DOI:10.2222/jsv.56.241
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
  Authors
Peloponese JM Jr, Jeang KT
  Title
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.
  Journal
J Biol Chem 281:8927-38 (2006)
DOI:10.1074/jbc.M510598200
Reference
  Authors
Marriott SJ, Semmes OJ
  Title
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.
  Journal
Oncogene 24:5986-95 (2005)
DOI:10.1038/sj.onc.1208976
Reference
  Authors
Jeang KT
  Title
Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.
  Journal
Cytokine Growth Factor Rev 12:207-17 (2001)
DOI:10.1016/S1359-6101(00)00028-9
Reference
  Authors
Bouzar AB, Willems L
  Title
How HTLV-1 may subvert miRNAs for persistence and transformation.
  Journal
Retrovirology 5:101 (2008)
DOI:10.1186/1742-4690-5-101
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
  Authors
Manel N, Battini JL, Taylor N, Sitbon M
  Title
HTLV-1 tropism and envelope receptor.
  Journal
Oncogene 24:6016-25 (2005)
DOI:10.1038/sj.onc.1208972
Reference
  Authors
Sun SC, Ballard DW
  Title
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
  Journal
Oncogene 18:6948-58 (1999)
DOI:10.1038/sj.onc.1203220
Reference
  Authors
Taylor GP, Matsuoka M
  Title
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy.
  Journal
Oncogene 24:6047-57 (2005)
DOI:10.1038/sj.onc.1208979
Reference
  Authors
Franchini G, Fukumoto R, Fullen JR
  Title
T-cell control by human T-cell leukemia/lymphoma virus type 1.
  Journal
Int J Hematol 78:280-96 (2003)
DOI:10.1007/BF02983552
Reference
  Authors
Baydoun HH, Bellon M, Nicot C
  Title
HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.
  Journal
AIDS Rev 10:195-204 (2008)
Reference
PMID:9325311
  Authors
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT
  Title
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
  Journal
J Biol Chem 272:25816-23 (1997)
DOI:10.1074/jbc.272.41.25816
Reference
  Authors
Pise-Masison CA, Brady JN
  Title
Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.
  Journal
Front Biosci 10:919-30 (2005)
KO pathway
 

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