KEGG   PATHWAY: ssg03440
Entry
ssg03440                    Pathway                                
Name
Homologous recombination - Selenomonas sputigena
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ssg03440  Homologous recombination
ssg03440

Other DBs
GO: 0000724
Organism
Selenomonas sputigena [GN:ssg]
Gene
Selsp_0761  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Selsp_2087  single-strand binding protein [KO:K03111]
Selsp_1347  single-strand binding protein [KO:K03111]
Selsp_0004  DNA replication and repair protein RecF [KO:K03629]
Selsp_1563  DNA repair protein RecO [KO:K03584]
Selsp_0019  recombination protein RecR [KO:K06187]
Selsp_0622  recA protein [KO:K03553]
Selsp_1087  Holliday junction DNA helicase RuvA [KO:K03550]
Selsp_1088  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Selsp_1086  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Selsp_0406  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Selsp_0730  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Selsp_0820  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Selsp_1579  transcriptional regulator, MarR family [KO:K03655] [EC:5.6.2.4]
Selsp_0355  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
Selsp_1252  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Selsp_1098  DNA polymerase III, alpha subunit [KO:K03763] [EC:2.7.7.7]
Selsp_2099  DNA polymerase III alpha subunit [KO:K03763] [EC:2.7.7.7]
Selsp_0003  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Selsp_0017  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Selsp_1180  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Selsp_1795  AAA ATPase central domain protein [KO:K02341] [EC:2.7.7.7]
Selsp_0842  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Selsp_1440  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG GENES (24)   
All databases (25)   

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