KEGG PATHWAY: ssi02010

PATHWAY: ssi02010

Entry

ssi02010 Pathway

Name

ABC transporters - Streptococcus suis P1/7

Description

The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).

Class

Environmental Information Processing; Membrane transport

Pathway map

ssi02010

ABC transporters

Module

ssi_M00185	Sulfate transport system [PATH:ssi02010]
ssi_M00186	Tungstate transport system [PATH:ssi02010]
ssi_M00189	Molybdate transport system [PATH:ssi02010]
ssi_M00190	Iron(III) transport system [PATH:ssi02010]
ssi_M00191	Thiamine transport system [PATH:ssi02010]
ssi_M00194	Maltose/maltodextrin transport system [PATH:ssi02010]
ssi_M00195	Maltooligosaccharide transport system [PATH:ssi02010]
ssi_M00196	Multiple sugar transport system [PATH:ssi02010]
ssi_M00198	Putative sn-glycerol-phosphate transport system [PATH:ssi02010]
ssi_M00199	L-Arabinose/lactose transport system [PATH:ssi02010]
ssi_M00200	Putative sorbitol/mannitol transport system [PATH:ssi02010]
ssi_M00201	alpha-Glucoside transport system [PATH:ssi02010]
ssi_M00202	Oligogalacturonide transport system [PATH:ssi02010]
ssi_M00203	Glucose/arabinose transport system [PATH:ssi02010]
ssi_M00204	Trehalose/maltose transport system [PATH:ssi02010]
ssi_M00205	N-Acetylglucosamine transport system [PATH:ssi02010]
ssi_M00206	Cellobiose transport system [PATH:ssi02010]
ssi_M00208	Glycine betaine/proline transport system [PATH:ssi02010]
ssi_M00209	Osmoprotectant transport system [PATH:ssi02010]
ssi_M00212	Ribose transport system [PATH:ssi02010]
ssi_M00213	L-Arabinose transport system [PATH:ssi02010]
ssi_M00214	Methyl-galactoside transport system [PATH:ssi02010]
ssi_M00215	D-Xylose transport system [PATH:ssi02010]
ssi_M00216	Multiple sugar transport system [PATH:ssi02010]
ssi_M00217	D-Allose transport system [PATH:ssi02010]
ssi_M00218	Fructose transport system [PATH:ssi02010]
ssi_M00219	AI-2 transport system [PATH:ssi02010]
ssi_M00220	Rhamnose transport system [PATH:ssi02010]
ssi_M00222	Phosphate transport system [PATH:ssi02010]
ssi_M00223	Phosphonate transport system [PATH:ssi02010]
ssi_M00224	Fluoroquinolones transport system [PATH:ssi02010]
ssi_M00225	Lysine/arginine/ornithine transport system [PATH:ssi02010]
ssi_M00226	Histidine transport system [PATH:ssi02010]
ssi_M00227	Glutamine transport system [PATH:ssi02010]
ssi_M00228	Putative glutamine transport system [PATH:ssi02010]
ssi_M00229	Arginine transport system [PATH:ssi02010]
ssi_M00230	Glutamate/aspartate transport system [PATH:ssi02010]
ssi_M00231	Octopine/nopaline transport system [PATH:ssi02010]
ssi_M00232	General L-amino acid transport system [PATH:ssi02010]
ssi_M00233	Glutamate transport system [PATH:ssi02010]
ssi_M00234	Cystine transport system [PATH:ssi02010]
ssi_M00235	Arginine/ornithine transport system [PATH:ssi02010]
ssi_M00237	Branched-chain amino acid transport system [PATH:ssi02010]
ssi_M00238	D-Methionine transport system [PATH:ssi02010]
ssi_M00239	Peptides/nickel transport system [PATH:ssi02010]
ssi_M00240	Iron complex transport system [PATH:ssi02010]
ssi_M00241	Vitamin B12 transport system [PATH:ssi02010]
ssi_M00242	Zinc transport system [PATH:ssi02010]
ssi_M00245	Cobalt/nickel transport system [PATH:ssi02010]
ssi_M00246	Nickel transport system [PATH:ssi02010]
ssi_M00248	Putative antibiotic transport system [PATH:ssi02010]
ssi_M00249	Capsular polysaccharide transport system [PATH:ssi02010]
ssi_M00250	Lipopolysaccharide transport system [PATH:ssi02010]
ssi_M00251	Teichoic acid transport system [PATH:ssi02010]
ssi_M00252	Lipooligosaccharide transport system [PATH:ssi02010]
ssi_M00253	Sodium transport system [PATH:ssi02010]
ssi_M00255	Lipoprotein-releasing system [PATH:ssi02010]
ssi_M00256	Cell division transport system [PATH:ssi02010]
ssi_M00257	Hemin transport system [PATH:ssi02010]
ssi_M00259	Heme transport system [PATH:ssi02010]
ssi_M00298	Multidrug/hemolysin transport system [PATH:ssi02010]
ssi_M00299	Spermidine/putrescine transport system [PATH:ssi02010]
ssi_M00300	Putrescine transport system [PATH:ssi02010]
ssi_M00301	Mannopine transport system [PATH:ssi02010]
ssi_M00302	2-Aminoethylphosphonate transport system [PATH:ssi02010]
ssi_M00314	Bacitracin transport system [PATH:ssi02010]
ssi_M00316	Manganese transport system [PATH:ssi02010]
ssi_M00317	Manganese/iron transport system [PATH:ssi02010]
ssi_M00318	Iron/zinc/copper transport system [PATH:ssi02010]
ssi_M00319	Manganese/zinc/iron transport system [PATH:ssi02010]
ssi_M00320	Lipopolysaccharide export system [PATH:ssi02010]
ssi_M00321	Bicarbonate transport system [PATH:ssi02010]
ssi_M00322	Neutral amino acid transport system [PATH:ssi02010]
ssi_M00323	Urea transport system [PATH:ssi02010]
ssi_M00324	Dipeptide transport system [PATH:ssi02010]
ssi_M00325	alpha-Hemolysin/cyclolysin transport system [PATH:ssi02010]
ssi_M00348	Glutathione transport system [PATH:ssi02010]
ssi_M00349	Microcin C transport system [PATH:ssi02010]
ssi_M00423	Molybdate/tungstate transport system [PATH:ssi02010]
ssi_M00435	Taurine transport system [PATH:ssi02010]
ssi_M00436	Sulfonate transport system [PATH:ssi02010]
ssi_M00437	Phthalate transport system [PATH:ssi02010]
ssi_M00438	Nitrate/nitrite transport system [PATH:ssi02010]
ssi_M00439	Oligopeptide transport system [PATH:ssi02010]
ssi_M00440	Nickel transport system [PATH:ssi02010]
ssi_M00442	Putative hydroxymethylpyrimidine transport system [PATH:ssi02010]
ssi_M00491	Putative arabinogalactan oligomer transport system [PATH:ssi02010]
ssi_M00566	Dipeptide transport system, Firmicutes [PATH:ssi02010]
ssi_M00581	Biotin transport system [PATH:ssi02010]
ssi_M00582	Energy-coupling factor transport system [PATH:ssi02010]
ssi_M00583	Putative peptide transport system [PATH:ssi02010]
ssi_M00584	Acetoin utilization transport system [PATH:ssi02010]
ssi_M00585	L-Cystine transport system [PATH:ssi02010]
ssi_M00586	Putative amino-acid transport system [PATH:ssi02010]

Other DBs

BSID:

103122

GO:

0043190 0043191 0043192

TC:

3.A.1

Organism

Streptococcus suis P1/7 [GN:ssi]

Gene

SSU0754	potD; spermidine/putrescine extracellular binding protein [KO:K11069]
SSU0753	potC; spermidine/putrescine ABC transporter permease [KO:K11070]
SSU0752	potB; spermidine/putrescine ABC transporter permease [KO:K11071]
SSU0751	potA; spermidine/putrescine ABC transporter ATP-binding protein [KO:K11072] [EC:3.6.3.31]
SSU1413	glycine/betaine ABC transporter; K05845 osmoprotectant transport system substrate-binding protein K05846 osmoprotectant transport system permease protein [KO:K05845 K05846]
SSU1414	glycine/betaine ABC transporter ATP-binding protein; K05847 osmoprotectant transport system ATP-binding protein [KO:K05847]
SSU1701	msmK; multiple sugar-binding transport ATP-binding protein [KO:K10112]
SSU1372	msmE; multiple sugar-binding protein precursor [KO:K10117]
SSU1371	msmF; multiple sugar-binding ABC transporter permease [KO:K10118]
SSU1370	msmG; multiple sugar-binding ABC transporter permease [KO:K10119]
SSU1915g	malX; maltose/maltodextrin-binding protein precursor [KO:K15770]
SSU1916	malC; maltose/maltodextrin ABC ABC transporter permease [KO:K15771]
SSU1917h	malD; maltose/maltodextrin ABC ABC transporter permease [KO:K15772]
SSU0953	pstS; phosphate ABC transporter substrate-binding protein [KO:K02040]
SSU0952	pstC; phosphate ABC transporter permease [KO:K02037]
SSU0951	phosphate ABC transporter permease; K02038 phosphate transport system permease protein [KO:K02038]
SSU0949	pstB1; phosphate transporter ATP-binding protein [KO:K02036] [EC:3.6.3.27]
SSU0950	pstB2; phosphate transporter ATP-binding protein [KO:K02036] [EC:3.6.3.27]
SSU1193	glutamine-binding protein precursor; K10039 putative glutamine transport system substrate-binding protein [KO:K10039]
SSU1194	amino acid ABC transporter permease; K10040 putative glutamine transport system permease protein [KO:K10040]
SSU1195	amino acid ABC transporter permease; K10040 putative glutamine transport system permease protein [KO:K10040]
SSU1192	glnQ4; glutamine transporter, ATP-binding protein 4 [KO:K10041] [EC:3.6.3.-]
SSU1853	amino acid ABC transporter substrate-binding protein; K02424 cystine transport system substrate-binding protein [KO:K02424]
SSU0284	extracellular solute-binding protein; K02424 cystine transport system substrate-binding protein [KO:K02424]
SSU1852	amino acid ABC transporter permease; K10009 cystine transport system permease protein [KO:K10009]
SSU0285	transport system membrane protein; K10009 cystine transport system permease protein [KO:K10009]
SSU1851	glnQ5; glutamine transporter, ATP-binding protein 5 [KO:K10010] [EC:3.6.3.-]
SSU1364	branched-chain amino acid ABC transporter; K01999 branched-chain amino acid transport system substrate-binding protein [KO:K01999]
SSU1363	branched-chain amino acid ABC transporter permease; K01997 branched-chain amino acid transport system permease protein [KO:K01997]
SSU1362	branched-chain amino acid ABC transporter permease; K01998 branched-chain amino acid transport system permease protein [KO:K01998]
SSU1361	branched-chain amino acid transport ATP-binding protein; K01995 branched-chain amino acid transport system ATP-binding protein [KO:K01995]
SSU1360	branched-chain amino acid transport ATP-binding protein; K01996 branched-chain amino acid transport system ATP-binding protein [KO:K01996]
SSU1577	lipoprotein; K02073 D-methionine transport system substrate-binding protein [KO:K02073]
SSU1574	D-methionine ABC transporter permease; K02072 D-methionine transport system permease protein [KO:K02072]
SSU1575	D-methionine transport ATP-binding protein; K02071 D-methionine transport system ATP-binding protein [KO:K02071]
SSU0606	fhuD; ferrichrome-binding protein precursor [KO:K02016]
SSU0604	fhuG; ferrichrome ABC transporter permease [KO:K02015]
SSU0605	fhuB; ferrichrome ABC transporter permease [KO:K02015]
SSU0607	fhuC; ferrichrome ABC transporter ATP-binding protein [KO:K02013] [EC:3.6.3.34]
SSU1482	ABC transporter ATP-binding protein; K02013 iron complex transport system ATP-binding protein [EC:3.6.3.34] [KO:K02013] [EC:3.6.3.34]
SSU0115	adcA; zinc-binding protein AdcA precursor [KO:K09815]
SSU0308	lmb; laminin binding protein [KO:K09815]
SSU0114	ABC transporter permease; K09816 zinc transport system permease protein [KO:K09816]
SSU0113	ABC transporter ATP-binding protein; K09817 zinc transport system ATP-binding protein [EC:3.6.3.-] [KO:K09817] [EC:3.6.3.-]
SSU1869	extracellular metal cation-binding protein; K11707 manganese/zinc/iron transport system substrate-binding protein [KO:K11707]
SSU1866	metal cation ABC transporter membrane protein; K11708 manganese/zinc/iron transport system permease protein [KO:K11708]
SSU1865	metal cation ABC transporter membrane protein; K11709 manganese/zinc/iron transport system permease protein [KO:K11709]
SSU1867	metal cation ABC transporter ATP-binding protein; K11710 manganese/zinc/iron transport system ATP- binding protein [KO:K11710]
SSU0462	BioY family protein; K03523 biotin transport system substrate-specific component [KO:K03523]
SSU0367	transport protein; K16785 energy-coupling factor transport system permease protein [KO:K16785]
SSU0691	cobalt transport family protein; K16785 energy-coupling factor transport system permease protein [KO:K16785]
SSU1951	cobalt transport protein; K16785 energy-coupling factor transport system permease protein [KO:K16785]
SSU0266	transporter protein; K16785 energy-coupling factor transport system permease protein [KO:K16785]
SSU1953	cbiO; cobalt transporter ATP-binding subunit [KO:K16786] [EC:3.6.3.-]
SSU0692	ABC transporter ATP-binding protein; K16786 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] [KO:K16786] [EC:3.6.3.-]
SSU0267	ABC transporter ATP-binding protein; K16786 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] K16787 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] [KO:K16786 K16787] [EC:3.6.3.- 3.6.3.-]
SSU0366	ABC transporter ATP-binding protein; K16786 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] K16787 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] [KO:K16786 K16787] [EC:3.6.3.- 3.6.3.-]
SSU0693	ABC transporter ATP-binding protein; K16787 energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] [KO:K16787] [EC:3.6.3.-]
SSU1952	cbiO; cobalt transporter ATP-binding subunit [KO:K16787] [EC:3.6.3.-]
SSU1498	ABC transporter; K09686 antibiotic transport system permease protein [KO:K09686]
SSU0835	lantibiotic transport ATP-binding protein; K09687 antibiotic transport system ATP-binding protein [KO:K09687]
SSU1499	ABC transporter ATP-binding protein; K09687 antibiotic transport system ATP-binding protein [KO:K09687]
SSU1238	ftsX; cell division protein [KO:K09811]
SSU1239	ftsE; cell division ATP-binding protein [KO:K09812]
SSU0263	ABC transporter ATP-binding protein; K06148 ATP-binding cassette, subfamily C, bacterial [KO:K06148]
SSU0264	ABC transporter ATP-binding protein; K06148 ATP-binding cassette, subfamily C, bacterial [KO:K06148]
SSU0912	ABC transporter ATP-binding protein; K06148 ATP-binding cassette, subfamily C, bacterial [KO:K06148]

Compound

C00009	Orthophosphate
C00025	L-Glutamate
C00031	D-Glucose
C00032	Heme
C00034	Manganese
C00037	Glycine
C00038	Zinc cation
C00041	L-Alanine
C00045	Amino acid
C00047	L-Lysine
C00049	L-Aspartate
C00051	Glutathione
C00059	Sulfate
C00062	L-Arginine
C00064	L-Glutamine
C00065	L-Serine
C00077	L-Ornithine
C00079	L-Phenylalanine
C00086	Urea
C00088	Nitrite
C00089	Sucrose
C00093	sn-Glycerol 3-phosphate
C00095	D-Fructose
C00098	Oligopeptide
C00107	Dipeptide
C00114	Choline
C00120	Biotin
C00121	D-Ribose
C00123	L-Leucine
C00134	Putrescine
C00135	L-Histidine
C00140	N-Acetyl-D-glucosamine
C00148	L-Proline
C00151	L-Amino acid
C00175	Cobalt ion
C00181	D-Xylose
C00183	L-Valine
C00185	Cellobiose
C00188	L-Threonine
C00208	Maltose
C00243	Lactose
C00244	Nitrate
C00245	Taurine
C00259	L-Arabinose
C00288	HCO3-
C00291	Nickel
C00315	Spermidine
C00320	Thiosulfate
C00333	D-Galacturonate
C00338	Lipopolysaccharide
C00378	Thiamine
C00392	Mannitol
C00407	L-Isoleucine
C00430	5-Aminolevulinate
C00470	Pectate
C00487	Carnitine
C00491	L-Cystine
C00719	Betaine
C00753	Tungsten
C00794	D-Sorbitol
C00855	D-Methionine
C00919	Choline sulfate
C00973	Cyclomaltodextrin
C01083	alpha,alpha-Trehalose
C01153	Orthophosphoric monoester
C01181	4-Trimethylammoniobutanoate
C01279	4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330	Sodium cation
C01417	Cyanate
C01487	D-Allose
C01606	Phthalate
C01667	Bacitracin
C01682	Nopaline
C01684	D-Rhamnose
C01834	Lipoprotein
C01835	Maltotriose
C01935	Maltodextrin
C03557	2-Aminoethylphosphonate
C03619	Methyl beta-D-galactoside
C04114	4-(Trimethylammonio)but-2-enoate
C04137	D-Octopine
C05349	Ciprofloxacin
C05776	Vitamin B12
C06227	Fe(III)hydroxamate
C06228	Ferrichrome
C06229	Fe(III)dicitrate
C06230	Fe-enterobactin
C06232	Molybdate
C06687	Norfloxacin
C06704	Iron chelate
C06705	Capsular polysaccharide
C06706	Lipo-oligosaccharide
C06707	Teichoic acid
C06767	Hemine
C07662	Sparfloxacin
C07663	Moxifloxacin
C11546	2-(beta-D-Glucosyl)-sn-glycerol
C14818	Fe2+
C14819	Fe3+
C15521	Alkanesulfonate
C16421	AI-2
C16692	Mannopine
C19609	Nickel(2+)
C19872	N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
G00457	Maltotetraose

Reference

PMID:9799792

Authors

Tomii K, Kanehisa M.

Title

A comparative analysis of ABC transporters in complete microbial genomes.

Journal

Genome Res 8:1048-59 (1998)

Reference

PMID:18424520

Authors

Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A

Title

Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.

Journal

J Bacteriol 190:4460-9 (2008)

Reference

PMID:18375759

Authors

Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ

Title

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.

Journal

Proc Natl Acad Sci U S A 105:5537-42 (2008)

Reference

PMID:10557362

Authors

Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T

Title

Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.

Journal

Proc Natl Acad Sci U S A 96:13571-6 (1999)

Reference

PMID:11731493

Authors

Quintero MJ, Montesinos ML, Herrero A, Flores E

Title

Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.

Journal

Genome Res 11:2034-40 (2001)

Reference

PMID:16135226

Authors

Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E

Title

ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.

Journal

Mol Microbiol 57:1582-92 (2005)

Reference

PMID:11929526

Authors

Valladares A, Montesinos ML, Herrero A, Flores E.

Title

An ABC-type, high-affinity urea permease identified in cyanobacteria.

Journal

Mol Microbiol 43:703-15 (2002)

Reference

PMID:18326572

Authors

Richard-Fogal CL, Frawley ER, Kranz RG

Title

Topology and function of CcmD in cytochrome c maturation.

Journal

J Bacteriol 190:3489-93 (2008)

Reference

PMID:16109926

Authors

Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H

Title

The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.

Journal

J Bacteriol 187:5861-7 (2005)

Reference

PMID:17873039

Authors

Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K

Title

The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.

Journal

J Bacteriol 189:8361-5 (2007)

Reference

PMID:17214741

Authors

Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI

Title

Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.

Journal

Mol Microbiol 63:895-910 (2007)

Reference

PMID:18805970

Authors

Yamanaka H, Kobayashi H, Takahashi E, Okamoto K

Title

MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.

Journal

J Bacteriol 190:7693-8 (2008)

KO pathway

ko02010

All links

Pathway (16)   
   KEGG MODULE (15)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (69)   
   KEGG GENES (69)   
All databases (86)   

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