KEGG   PATHWAY: sta00760Help
Entry
sta00760                    Pathway                                

Name
Nicotinate and nicotinamide metabolism - Spirochaeta thermophila DSM 6192
Class
Metabolism; Metabolism of cofactors and vitamins
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Nicotinate and nicotinamide metabolism
sta00760

All organismsOrtholog table
Module
NAD biosynthesis, aspartate => NAD [PATH:sta00760]
Other DBs
BSID: 
UMBBD: 
GO: 
Organism
Spirochaeta thermophila DSM 6192 [GN:sta]
Gene
L-aspartate oxidase; K00278 L-aspartate oxidase [EC:1.4.3.16] [KO:K00278] [EC:1.4.3.16]
quinolinate synthetase A 1; K03517 quinolinate synthase [EC:2.5.1.72] [KO:K03517] [EC:2.5.1.72]
hypothetical protein; K00767 nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] [KO:K00767] [EC:2.4.2.19]
hypothetical protein; K00763 nicotinate phosphoribosyltransferase [EC:6.3.4.21] [KO:K00763] [EC:6.3.4.21]
purine nucleoside phosphorylase deoD-type; K03784 purine-nucleoside phosphorylase [EC:2.4.2.1] [KO:K03784] [EC:2.4.2.1]
surE; 5'-nucleotidase [KO:K03787] [EC:3.1.3.5]
nicotinate-nucleotide adenylyltransferase; K00969 nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] [KO:K00969] [EC:2.7.7.18]
nadE; glutamine-dependent NAD(+) synthetase [KO:K01950] [EC:6.3.5.1]
CinA-like protein; K03742 nicotinamide-nucleotide amidase [EC:3.5.1.42] [KO:K03742] [EC:3.5.1.42]
hypothetical protein; K08281 nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] [KO:K08281] [EC:3.5.1.- 3.5.1.19]
inorganic polyphosphate/ATP-NAD kinase; K00858 NAD+ kinase [EC:2.7.1.23] [KO:K00858] [EC:2.7.1.23]
Compound
C00003  
NAD+
C00006  
NADP+
C00022  
Pyruvate
C00049  
L-Aspartate
C00111  
Glycerone phosphate
C00122  
Fumarate
C00153  
Nicotinamide
C00163  
Propanoate
C00232  
Succinate semialdehyde
C00253  
Nicotinate
C00334  
4-Aminobutanoate
C00455  
Nicotinamide D-ribonucleotide
C00857  
Deamino-NAD+
C00922  
2,3-Dimethylmaleate
C01004  
N-Methylnicotinate
C01020  
6-Hydroxynicotinate
C01056  
(S)-6-Hydroxynicotine
C01059  
2,5-Dihydroxypyridine
C01185  
Nicotinate D-ribonucleotide
C01297  
6-Hydroxypseudooxynicotine
C01384  
Maleic acid
C01596  
Maleamate
C02295  
Methylitaconate
C02918  
1-Methylnicotinamide
C02930  
2-Methyleneglutarate
C03043  
(R)-6-Hydroxynicotine
C03056  
2,6-Dihydroxypyridine
C03150  
Nicotinamide-beta-riboside
C03458  
2,3,6-Trihydroxypyridine
C03652  
(2R,3S)-2,3-Dimethylmalate
C03722  
Quinolinate
C04226  
6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  
Nicotinurate
C05840  
Iminoaspartate
C05841  
Nicotinate D-ribonucleoside
C05842  
N1-Methyl-2-pyridone-5-carboxamide
C05843  
N1-Methyl-4-pyridone-5-carboxamide
C06178  
1-Methylpyrrolinium
C15523  
2,6-Dihydroxynicotinate
C15986  
2,6-Dihydroxypseudooxynicotine
C15987  
4-Methylaminobutyrate
C16150  
(R,S)-Nicotine
C16151  
2,6-Dihydroxy-N-methylmyosmine
C16152  
Blue pigment
C16159  
2-Formylglutarate
C16390  
(S)-2-(Hydroxymethyl)glutarate
C18232  
N-Formylmaleamic acid
C19631  
6-Hydroxy-3-succinoylpyridine
C20381  
3,3'-Bipyridine-2,2',5,5',6,6'-hexol
Reference
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
Reference
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
Reference
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
KO pathway
 

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