KEGG   PATHWAY: stn03440Help
Entry
stn03440                    Pathway                                

Name
Homologous recombination - Streptococcus thermophilus ND03
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
stn03440  Homologous recombination
stn03440

Ortholog table
Module
stn_M00260  DNA polymerase III complex, bacteria [PATH:stn03440]
Other DBs
BSID: 610816
GO: 0000724
Organism
Streptococcus thermophilus ND03 [GN:stn]
Gene
STND_1161  Exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
STND_1687  Single-stranded DNA-binding protein [KO:K03111]
STND_1783  Single-stranded DNA-binding protein [KO:K03111]
STND_1958  DNA replication and repair protein recF [KO:K03629]
STND_0024  DNA repair protein recO [KO:K03584]
STND_0614  Recombination protein recR [KO:K06187]
STND_0066  recombinase A [KO:K03553]
STND_1696  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
STND_0063  Holliday junction ATP-dependent DNA helicase ruvA [KO:K03550] [EC:3.6.4.12]
STND_1887  Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:3.6.4.12]
STND_1661  ATP-dependent DNA helicase recG, transcription-repair coupling factor, putative [KO:K03655] [EC:3.6.4.12]
STND_1702  ATP-dependent DNA helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
STND_1134  DNA polymeraDNA polymerase III alphase III alpha subunit [KO:K02337] [EC:2.7.7.7]
STND_0068  DNA polymerase III polC-type [KO:K03763] [EC:2.7.7.7]
STND_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
STND_1101  DNA polymerase III, tau subunit [KO:K02343] [EC:2.7.7.7]
STND_0709  DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
STND_0487  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
STND_1536  DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
STND_1361  Replication restart DNA helicase PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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