KEGG   PATHWAY: svi03440Help
Entry
svi03440                    Pathway                                

Name
Homologous recombination - Saccharomonospora viridis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
svi03440  Homologous recombination
svi03440

Ortholog table
Module
svi_M00260  DNA polymerase III complex, bacteria [PATH:svi03440]
Other DBs
BSID: 120760
GO: 0000724
Organism
Saccharomonospora viridis [GN:svi]
Gene
Svir_39400  single-strand binding protein [KO:K03111]
Svir_00040  DNA replication and repair protein RecF [KO:K03629]
Svir_13640  DNA replication and repair protein RecO [KO:K03584]
Svir_36550  DNA replication and repair protein RecR [KO:K06187]
Svir_27820  protein RecA [KO:K03553]
Svir_25960  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Svir_13430  DNA polymerase I family protein with 3'-5'-exonuclease and polymerase domains [KO:K02335] [EC:2.7.7.7]
Svir_15070  Holliday junction DNA helicase subunit RuvA [KO:K03550] [EC:3.6.4.12]
Svir_15080  Holliday junction DNA helicase subunit RuvB [KO:K03551] [EC:3.6.4.12]
Svir_15060  Holliday junction endonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Svir_09240  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Svir_10390  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Svir_00020  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Svir_36570  DNA polymerase III, subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
Svir_12630  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Svir_35780  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Svir_10720  exonuclease, DNA polymerase III, epsilon subunit family [KO:K02342] [EC:2.7.7.7]
Svir_15670  primosomal protein N' (replication factor Y) - superfamily II helicase [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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