KEGG   PATHWAY: svl03440
Entry
svl03440                    Pathway                                
Name
Homologous recombination - Streptomyces violaceusniger
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
svl03440  Homologous recombination
svl03440

Other DBs
GO: 0000724
Organism
Streptomyces violaceusniger [GN:svl]
Gene
Strvi_9207  single-strand binding protein [KO:K03111]
Strvi_7724  single-strand binding protein [KO:K03111]
Strvi_7964  single-strand binding protein/Primosomal replication protein n [KO:K03111]
Strvi_0254  DNA replication and repair protein recF [KO:K03629]
Strvi_7799  DNA repair protein recO [KO:K03584]
Strvi_9042  Recombination protein recR [KO:K06187]
Strvi_2100  Protein recA [KO:K03553]
Strvi_7075  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Strvi_3029  Holliday junction ATP-dependent DNA helicase ruvA [KO:K03550]
Strvi_3030  Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:5.6.2.4]
Strvi_3028  Crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.21.10]
Strvi_1918  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Strvi_8030  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
Strvi_7145  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Strvi_0252  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Strvi_2731  transcriptional regulator, MerR family [KO:K02338] [EC:2.7.7.7]
Strvi_9044  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Strvi_7856  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Strvi_8968  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Strvi_2350  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Strvi_3014  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Strvi_3138  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Strvi_9432  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Strvi_0150  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Strvi_6917  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Strvi_3075  primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG GENES (26)   
All databases (27)   

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