KEGG   PATHWAY: tag00010
Entry
tag00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Thermosphaera aggregans
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
tag00010  Glycolysis / Gluconeogenesis
tag00010

Module
tag_M00002  Glycolysis, core module involving three-carbon compounds [PATH:tag00010]
tag_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:tag00010]
tag_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:tag00010]
Other DBs
GO: 0006096 0006094
Organism
Thermosphaera aggregans [GN:tag]
Gene
Tagg_0486  ROK family protein [KO:K25026] [EC:2.7.1.2]
Tagg_0065  hypothetical protein [KO:K15916] [EC:5.3.1.9 5.3.1.8]
Tagg_0554  fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
Tagg_1241  D-fructose 1,6-bisphosphatase [KO:K01622] [EC:4.1.2.13 3.1.3.11]
Tagg_1240  triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
Tagg_0301  glyceraldehyde-3-phosphate dehydrogenase, type II [KO:K00150] [EC:1.2.1.59]
Tagg_0302  phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
Tagg_0654  phosphoglycerate mutase [KO:K15635] [EC:5.4.2.12]
Tagg_0174  enolase [KO:K01689] [EC:4.2.1.11]
Tagg_1237  pyruvate kinase [KO:K00873] [EC:2.7.1.40]
Tagg_0532  phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2]
Tagg_0410  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Tagg_0387  pyruvate ferredoxin oxidoreductase, alpha subunit [KO:K00169] [EC:1.2.7.1]
Tagg_0827  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00169] [EC:1.2.7.1]
Tagg_0386  thiamine pyrophosphate protein domain protein TPP-binding protein [KO:K00170] [EC:1.2.7.1]
Tagg_0826  thiamine pyrophosphate protein domain protein TPP-binding protein [KO:K00170] [EC:1.2.7.1]
Tagg_0389  pyruvate/ketoisovalerate oxidoreductase, gamma subunit [KO:K00172] [EC:1.2.7.1]
Tagg_0829  pyruvate/ketoisovalerate oxidoreductase, gamma subunit [KO:K00172] [EC:1.2.7.1]
Tagg_0388  pyruvate ferredoxin oxidoreductase, delta subunit [KO:K00171] [EC:1.2.7.1]
Tagg_0828  pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit [KO:K00171] [EC:1.2.7.1]
Tagg_0391  2-oxoglutarate ferredoxin oxidoreductase, alpha subunit [KO:K00174] [EC:1.2.7.3 1.2.7.11]
Tagg_1264  2-oxoglutarate synthase [KO:K00174] [EC:1.2.7.3 1.2.7.11]
Tagg_0392  2-oxoglutarate ferredoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.3 1.2.7.11]
Tagg_1265  pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.3 1.2.7.11]
Tagg_0918  zinc-binding alcohol dehydrogenase family protein [KO:K13953] [EC:1.1.1.1]
Tagg_0726  branched-chain acyl-CoA synthetase (ADP-forming) alpha subunit; acetyl-CoA synthetase (ADP-forming) alpha subunit [KO:K01905] [EC:6.2.1.13]
Tagg_0142  CoA-binding domain protein [KO:K01905] [EC:6.2.1.13]
Tagg_0143  acetyl-CoA synthetase (ADP-forming) beta subunit; branched-chain acyl-CoA synthetase (ADP-forming) beta subunit [KO:K22224] [EC:6.2.1.13]
Tagg_0340  acetyl-CoA synthetase (ADP-forming) beta subunit; branched-chain acyl-CoA synthetase (ADP-forming) beta subunit [KO:K22224] [EC:6.2.1.13]
Tagg_0185  Phosphoglucosamine mutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
Tagg_0458  phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I [KO:K15778] [EC:5.4.2.8 5.4.2.2]
Tagg_0452  glyceraldehyde-3-phosphate ferredoxin oxidoreductase [KO:K11389] [EC:1.2.7.6]
Tagg_1262  nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase [KO:K18978] [EC:1.2.1.90]
Tagg_0003  Phosphoenolpyruvate carboxykinase (GTP) [KO:K01596] [EC:4.1.1.32]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
tag00020  Citrate cycle (TCA cycle)
tag00030  Pentose phosphate pathway
tag00500  Starch and sucrose metabolism
tag00620  Pyruvate metabolism
tag00640  Propanoate metabolism
KO pathway
ko00010   

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