KEGG   PATHWAY: tdl03440Help
Entry
tdl03440                    Pathway                                

Name
Homologous recombination - Torulaspora delbrueckii
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
tdl03440  Homologous recombination
tdl03440

Ortholog table
Module
tdl_M00292  MRX complex [PATH:tdl03440]
Other DBs
BSID: 701652
GO: 0000724
Organism
Torulaspora delbrueckii [GN:tdl]
Gene
TDEL_0C05910  TDEL0C05910; hypothetical protein [KO:K10866] [EC:3.6.-.-]
TDEL_0B03650  TDEL0B03650; hypothetical protein [KO:K10865]
TDEL_0E01900  TDEL0E01900; hypothetical protein [KO:K10868]
TDEL_0C02790  TDEL0C02790; hypothetical protein [KO:K04728] [EC:2.7.11.1]
TDEL_0E01980  TDEL0E01980; hypothetical protein [KO:K10881]
TDEL_0B04100  TDEL0B04100; hypothetical protein [KO:K10957]
TDEL_0D04240  TDEL0D04240; hypothetical protein [KO:K10958]
TDEL_0F02250  TDEL0F02250; hypothetical protein [KO:K07466]
TDEL_0A00520  TDEL0A00520; hypothetical protein [KO:K10739]
TDEL_0C01620  TDEL0C01620; hypothetical protein [KO:K04482]
TDEL_0A04400  TDEL0A04400; hypothetical protein [KO:K10873]
TDEL_0E01320  TDEL0E01320; hypothetical protein [KO:K10959]
TDEL_0C01370  TDEL0C01370; hypothetical protein [KO:K10875] [EC:3.6.4.-]
TDEL_0D03340  TDEL0D03340; hypothetical protein [KO:K10877] [EC:3.6.4.-]
TDEL_0G02810  TDEL0G02810; hypothetical protein [KO:K02327] [EC:2.7.7.7]
TDEL_0E04540  TDEL0E04540; hypothetical protein [KO:K02328]
TDEL_0B05430  TDEL0B05430; hypothetical protein [KO:K03504]
TDEL_0A06910  TDEL0A06910; hypothetical protein [KO:K10901] [EC:3.6.4.12]
TDEL_0F05380  TDEL0F05380; hypothetical protein [KO:K03165] [EC:5.99.1.2]
TDEL_0A03320  TDEL0A03320; hypothetical protein [KO:K08991] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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