KEGG   PATHWAY: tet03440Help
Entry
tet03440                    Pathway                                

Name
Homologous recombination - Tetrahymena thermophila
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
tet03440

All organismsOrtholog table
Module
MRN complex [PATH:tet03440]
Other DBs
BSID: 
GO: 
Organism
Tetrahymena thermophila [GN:tet]
Gene
DNA polymerase I family protein; K02335 DNA polymerase I [EC:2.7.7.7] [KO:K02335] [EC:2.7.7.7]
hypothetical protein; K10866 DNA repair protein RAD50 [EC:3.6.-.-] [KO:K10866] [EC:3.6.-.-]
Ser/Thr protein phosphatase family protein; K10865 double-strand break repair protein MRE11 [KO:K10865]
hypothetical protein; K10867 nijmegen breakage syndrome protein 1 [KO:K10867]
hypothetical protein; K07466 replication factor A1 [KO:K07466]
DNA repair protein RAD51 containing protein; K04482 DNA repair protein RAD51 [KO:K04482]
DSS1/SEM1 family protein; K10881 26 proteasome complex subunit DSS1 [KO:K10881]
SNF2 family N-terminal domain containing protein; K10877 DNA repair and recombination protein RAD54B [EC:3.6.4.-] [KO:K10877] [EC:3.6.4.-]
DNA polymerase family B containing protein; K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] [KO:K02327] [EC:2.7.7.7]
hypothetical protein; K02328 DNA polymerase delta subunit 2 [KO:K02328]
ATP-dependent DNA helicase; K10901 bloom syndrome protein [EC:3.6.4.12] [KO:K10901] [EC:3.6.4.12]
DNA topoisomerase family protein; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
DNA topoisomerase family protein; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
DNA topoisomerase family protein; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
DNA topoisomerase family protein; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
ERCC4 domain containing protein; K08991 crossover junction endonuclease MUS81 [EC:3.1.22.-] [KO:K08991] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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