KEGG PATHWAY: tgo04145

PATHWAY: tgo04145

Entry

tgo04145 Pathway

Name

Phagosome - Toxoplasma gondii

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

tgo04145

Phagosome

Module

tgo_M00401

Sec61 complex [PATH:tgo04145]

Other DBs

BSID:

153992

GO:

0045335

Organism

Toxoplasma gondii [GN:tgo]

Gene

TGME49_070070	vesicle trafficking protein; K08517 vesicle transport protein SEC22 [KO:K08517]
TGME49_056970	vacuolar ATP synthase catalytic subunit A; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
TGME49_019800	vacuolar ATP synthase subunit B; K02147 V-type H+-transporting ATPase subunit B [EC:3.6.3.14] [KO:K02147] [EC:3.6.3.14]
TGME49_115620	vacuolar ATP synthase subunit C; K02148 V-type H+-transporting ATPase subunit C [EC:3.6.3.14] [KO:K02148] [EC:3.6.3.14]
TGME49_081920	vacuolar ATP synthase subunit D; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
TGME49_105290	vacuolar ATP synthase subunit E; K02150 V-type H+-transporting ATPase subunit E [EC:3.6.3.14] [KO:K02150] [EC:3.6.3.14]
TGME49_110960	vacuolar ATP synthase subunit F; K02151 V-type H+-transporting ATPase subunit F [EC:3.6.3.14] [KO:K02151] [EC:3.6.3.14]
TGME49_046560	vacuolar ATP synthase subunit G1; K02152 V-type H+-transporting ATPase subunit G [EC:3.6.3.14] [KO:K02152] [EC:3.6.3.14]
TGME49_090720	vacuolar proton-translocating ATPase subunit; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
TGME49_032830	vacuolar proton-translocating ATPase subunit; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
TGME49_059010	vacuolar ATP synthase subunit D; K02146 V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14] [KO:K02146] [EC:3.6.3.14]
TGME49_008590	vacuolar ATP synthase subunit H; K02144 V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14] [KO:K02144] [EC:3.6.3.14]
TGME49_012310	vacuolar ATP synthase 16 kDa proteolipid subunit; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
TGME49_023250	vacuolar type H+-ATPase proteolipid subunit; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
TGME49_091310	vacuolar ATP synthase 22 kDa proteolipid subunit; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
TGME49_048880	Ras family domain-containing protein; K07897 Ras-related protein Rab-7A [KO:K07897]
TGME49_094550	dynein heavy chain; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
TGME49_077510	dynein intermediate chain; K10415 dynein intermediate chain, cytosolic [KO:K10415]
TGME49_047600	hypothetical protein; K10416 dynein light intermediate chain 1, cytosolic [KO:K10416]
TGME49_116400	tubulin alpha chain; K07374 tubulin alpha [KO:K07374]
TGME49_031400	tubulin alpha chain; K07374 tubulin alpha [KO:K07374]
TGME49_031770	tubulin alpha chain; K07374 tubulin alpha [KO:K07374]
TGME49_012240	tubulin beta chain; K07375 tubulin beta [KO:K07375]
TGME49_066960	tubulin beta chain; K07375 tubulin beta [KO:K07375]
TGME49_021620	tubulin beta chain; K07375 tubulin beta [KO:K07375]
TGME49_069980	protein transport protein Sec61 alpha subunit isoform 1; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
TGME49_011040	Sec61beta family protein; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
TGME49_030380	protein translocation complex; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
TGME49_110320	calnexin; K08054 calnexin [KO:K08054]

Compound

C00007	Oxygen
C00027	Hydrogen peroxide
C00533	Nitric oxide
C00704	O2.-
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)

KO pathway

ko04145

All links

Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG GENES (29)   
All databases (32)   

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