KEGG   PATHWAY: tgo04145Help
Entry
tgo04145                    Pathway                                

Name
Phagosome - Toxoplasma gondii
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
tgo04145

All organismsOrtholog table
Module
Sec61 complex [PATH:tgo04145]
Other DBs
BSID: 
GO: 
Organism
Toxoplasma gondii [GN:tgo]
Gene
vesicle trafficking protein; K08517 vesicle transport protein SEC22 [KO:K08517]
vacuolar ATP synthase catalytic subunit A; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
vacuolar ATP synthase subunit B; K02147 V-type H+-transporting ATPase subunit B [KO:K02147]
vacuolar ATP synthase subunit C; K02148 V-type H+-transporting ATPase subunit C [KO:K02148]
vacuolar ATP synthase subunit D; K02149 V-type H+-transporting ATPase subunit D [KO:K02149]
vacuolar ATP synthase subunit E; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
vacuolar ATP synthase subunit F; K02151 V-type H+-transporting ATPase subunit F [KO:K02151]
vacuolar ATP synthase subunit G1; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
vacuolar proton-translocating ATPase subunit; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
vacuolar proton-translocating ATPase subunit; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
vacuolar ATP synthase subunit D; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
vacuolar ATP synthase subunit H; K02144 V-type H+-transporting ATPase subunit H [KO:K02144]
vacuolar ATP synthase 16 kDa proteolipid subunit; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
vacuolar type H+-ATPase proteolipid subunit; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
vacuolar ATP synthase 22 kDa proteolipid subunit; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
Ras family domain-containing protein; K07897 Ras-related protein Rab-7A [KO:K07897]
dynein heavy chain; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
dynein intermediate chain; K10415 dynein intermediate chain, cytosolic [KO:K10415]
hypothetical protein; K10416 dynein light intermediate chain 1, cytosolic [KO:K10416]
tubulin alpha chain; K07374 tubulin alpha [KO:K07374]
tubulin alpha chain; K07374 tubulin alpha [KO:K07374]
tubulin alpha chain; K07374 tubulin alpha [KO:K07374]
tubulin beta chain; K07375 tubulin beta [KO:K07375]
tubulin beta chain; K07375 tubulin beta [KO:K07375]
tubulin beta chain; K07375 tubulin beta [KO:K07375]
protein transport protein Sec61 alpha subunit isoform 1; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
Sec61beta family protein; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
protein translocation complex; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
calnexin; K08054 calnexin [KO:K08054]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 

DBGET integrated database retrieval system