KEGG   PATHWAY: tpd03440
Entry
tpd03440                    Pathway                                
Name
Homologous recombination - Thermoanaerobacter pseudethanolicus
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
tpd03440  Homologous recombination
tpd03440

Other DBs
GO: 0000724
Organism
Thermoanaerobacter pseudethanolicus [GN:tpd]
Gene
Teth39_1026  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Teth39_2274  single-strand binding protein [KO:K03111]
Teth39_0004  DNA replication and repair protein RecF [KO:K03629]
Teth39_1363  DNA repair protein RecO [KO:K03584]
Teth39_2198  recombination protein RecR [KO:K06187]
Teth39_1191  recA protein [KO:K03553]
Teth39_1013  Holliday junction DNA helicase RuvA [KO:K03550]
Teth39_1014  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Teth39_1012  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Teth39_1305  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Teth39_1789  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
Teth39_0681  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Teth39_1214  DNA polymerase III, alpha subunit [KO:K03763] [EC:2.7.7.7]
Teth39_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Teth39_2200  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Teth39_1405  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Teth39_2147  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Teth39_1321  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG GENES (18)   
All databases (19)   

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