KEGG   PATHWAY: tpo03440Help
Entry
tpo03440                    Pathway                                

Name
Homologous recombination - Treponema pallidum subsp. pallidum Mexico A
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
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Pathway map
Homologous recombination
tpo03440

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Organism
Treponema pallidum subsp. pallidum Mexico A [GN:tpo]
Gene
recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
ssb1; single-strand DNA-binding protein [KO:K03111]
recF; recombination protein F [KO:K03629]
recR; recombination protein R [KO:K06187]
recA; recombination protein A [KO:K03553]
polA; DNA-directed DNA polymerase I [KO:K02335] [EC:2.7.7.7]
ruvA; crossover junction endoribonuclease subunit A [KO:K03550] [EC:3.6.4.12]
ruvB; crossover junction endoribonuclease subunit B [KO:K03551] [EC:3.6.4.12]
ruvC; crossover junction endoribonuclease subunit C [KO:K01159] [EC:3.1.22.4]
recG; DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
dnaE; DNA-directed DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
dnaN; DNA-directed DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
dnaZX1; DNA-directed DNA polymerase III gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
dnaZX2; DNA-directed DNA polymerase III gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
holA; DNA-directed DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
dnaQ; DNA-directed DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
priA; DNA replication factor Y [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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