KEGG   PATHWAY: tpp03440
Entry
tpp03440                    Pathway                                
Name
Homologous recombination - Treponema pallidum subsp. pallidum SS14
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
tpp03440  Homologous recombination
tpp03440

Other DBs
GO: 0000724
Organism
Treponema pallidum subsp. pallidum SS14 [GN:tpp]
Gene
TPASS_0704  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
TPASS_0062  ssb; single-strand DNA binding protein Ssb [KO:K03111]
TPASS_0310  hypothetical protein [KO:K03111]
TPASS_0003  recF; recombination protein RecF [KO:K03629]
TPASS_1004  recR; recombination protein RecR [KO:K06187]
TPASS_0692  recA; protein RecA [KO:K03553]
TPASS_0543  ruvA; Holliday junction DNA helicase, subunit A [KO:K03550]
TPASS_0162  ruvB; Holliday junction DNA helicase, subunit B [KO:K03551] [EC:5.6.2.4]
TPASS_0517  ruvC; Holliday junction nuclease, subunit C [KO:K01159] [EC:3.1.21.10]
TPASS_0687  recG; DNA recombinase [KO:K03655] [EC:5.6.2.4]
TPASS_0669  dnaE; DNA polymerase III, subunit alpha [KO:K02337] [EC:2.7.7.7]
TPASS_0002  dnaN; DNA-directed DNA polymerase beta subunit [KO:K02338] [EC:2.7.7.7]
TPASS_1005  dnaZX; DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
TPASS_0521  possible DNA polymerase III, gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
TPASS_0588  hypothetical protein [KO:K02340] [EC:2.7.7.7]
TPASS_0643  dnaQ; DNA polymerase III, subunit epsilon [KO:K02342] [EC:2.7.7.7]
TPASS_0230  priA; primosomal protein N [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG GENES (17)   
All databases (18)   

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