KEGG   PATHWAY: tsa03440Help
Entry
tsa03440                    Pathway                                

Name
Homologous recombination - Terriglobus saanensis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
tsa03440  Homologous recombination
tsa03440

Ortholog table
Other DBs
BSID: 198061
GO: 0000724
Organism
Terriglobus saanensis [GN:tsa]
Gene
AciPR4_1866  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
AciPR4_2945  single-strand binding protein [KO:K03111]
AciPR4_0898  single-strand binding protein [KO:K03111]
AciPR4_1179  DNA repair protein RecO [KO:K03584]
AciPR4_1502  recombination protein RecR [KO:K06187]
AciPR4_0691  recA protein [KO:K03553]
AciPR4_1268  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
AciPR4_4235  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
AciPR4_3416  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
AciPR4_2469  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
AciPR4_2625  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
AciPR4_1938  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
AciPR4_4224  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
AciPR4_1504  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
AciPR4_0682  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
AciPR4_1895  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
AciPR4_1311  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

DBGET integrated database retrieval system