KEGG   PATHWAY: tve03440
Entry
tve03440                    Pathway                                
Name
Homologous recombination - Trichophyton verrucosum
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
tve03440  Homologous recombination
tve03440

Other DBs
GO: 0000724
Organism
Trichophyton verrucosum [GN:tve]
Gene
TRV_03421  hypothetical protein [KO:K10865]
TRV_08071  phosphotidylinositol kinase Tel1, putative [KO:K04728] [EC:2.7.11.1]
TRV_03922  hypothetical protein [KO:K10881]
TRV_05153  DNA repair protein (Rad57), putative [KO:K10958]
TRV_00711  hypothetical protein [KO:K07466]
TRV_01408  possible replication factor-a protein [KO:K10739]
TRV_03925  hypothetical protein [KO:K04482]
TRV_03545  RAD52 DNA repair protein RADC [KO:K10873]
TRV_06277  hypothetical protein [KO:K10875] [EC:5.6.2.-]
TRV_04621  hypothetical protein [KO:K10877] [EC:5.6.2.-]
TRV_02480  POL3; Catalytic subunit of DNA polymerase delta [KO:K02327] [EC:2.7.7.7]
TRV_02865  hypothetical protein [KO:K02328]
TRV_02492  hypothetical protein [KO:K03504]
TRV_00602  DNA polymerase delta subunit 4, putative [KO:K03505]
TRV_07620  RecQ family helicase MusN [KO:K10901] [EC:5.6.2.4]
TRV_04955  hypothetical protein [KO:K03165] [EC:5.6.2.1]
TRV_06117  hypothetical protein [KO:K03165] [EC:5.6.2.1]
TRV_00910  hypothetical protein [KO:K08991] [EC:3.1.22.-]
TRV_05565  hypothetical protein [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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