KEGG   PATHWAY: uma04141Help
Entry
uma04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Ustilago maydis
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein processing in endoplasmic reticulum
uma04141

All organismsOrtholog table
Module
SCF-FBS complex [PATH:uma04141]
p97-Ufd1-Npl4 complex [PATH:uma04141]
Sec61 complex [PATH:uma04141]
Translocon-associated protein (TRAP) complex [PATH:uma04141]
HRD1/SEL1 ERAD complex [PATH:uma04141]
COPII complex [PATH:uma04141]
Other DBs
Organism
Ustilago maydis [GN:uma]
Gene
hypothetical protein; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
hypothetical protein; K12275 translocation protein SEC62 [KO:K12275]
hypothetical protein; K09540 translocation protein SEC63 [KO:K09540]
hypothetical protein; K12666 oligosaccharyltransferase complex subunit alpha (ribophorin I) [KO:K12666]
hypothetical protein; K12669 oligosaccharyltransferase complex subunit gamma [KO:K12669]
hypothetical protein; K12670 oligosaccharyltransferase complex subunit beta [KO:K12670]
hypothetical protein; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:2.4.99.18] [KO:K07151] [EC:2.4.99.18]
hypothetical protein; K01228 mannosyl-oligosaccharide glucosidase [EC:3.2.1.106] [KO:K01228] [EC:3.2.1.106]
hypothetical protein; K09486 hypoxia up-regulated 1 [KO:K09486]
hypothetical protein; K09523 DnaJ homolog subfamily C member 3 [KO:K09523]
hypothetical protein; K05546 alpha 1,3-glucosidase [EC:3.2.1.84] [KO:K05546] [EC:3.2.1.84]
hypothetical protein; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
hypothetical protein; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
hypothetical protein; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113] [KO:K01230] [EC:3.2.1.113]
hypothetical protein; K10082 lectin, mannose-binding 2 [KO:K10082]
hypothetical protein; K14003 prolactin regulatory element-binding protein [KO:K14003]
similar to small GTP-binding protein; K07953 GTP-binding protein SAR1 [EC:3.6.5.-] [KO:K07953] [EC:3.6.5.-]
hypothetical protein; K14004 protein transport protein SEC13 [KO:K14004]
hypothetical protein; K14005 protein transport protein SEC31 [KO:K14005]
hypothetical protein; K14006 protein transport protein SEC23 [KO:K14006]
hypothetical protein; K14007 protein transport protein SEC24 [KO:K14007]
hypothetical protein; K14007 protein transport protein SEC24 [KO:K14007]
hypothetical protein; K11718 UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-] [KO:K11718] [EC:2.4.1.-]
hypothetical protein; K09580 protein disulfide-isomerase A1 [EC:5.3.4.1] [KO:K09580] [EC:5.3.4.1]
hypothetical protein; K09584 protein disulfide-isomerase A6 [EC:5.3.4.1] [KO:K09584] [EC:5.3.4.1]
hypothetical protein; K09584 protein disulfide-isomerase A6 [EC:5.3.4.1] [KO:K09584] [EC:5.3.4.1]
hypothetical protein; K13989 Derlin-2/3 [KO:K13989]
hypothetical protein; K14012 UBX domain-containing protein 1 [KO:K14012]
hypothetical protein; K13525 transitional endoplasmic reticulum ATPase [KO:K13525]
hypothetical protein; K14015 nuclear protein localization protein 4 homolog [KO:K14015]
hypothetical protein; K14016 ubiquitin fusion degradation protein 1 [KO:K14016]
similar to heat shock protein 70 family; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
hypothetical protein; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
hypothetical protein; K09503 DnaJ homolog subfamily A member 2 [KO:K09503]
hypothetical protein; K09518 DnaJ homolog subfamily B member 12 [KO:K09518]
hypothetical protein; K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-] [KO:K13719] [EC:3.1.2.-]
hypothetical protein; K14018 phospholipase A-2-activating protein [KO:K14018]
hypothetical protein; K10839 UV excision repair protein RAD23 [KO:K10839]
hypothetical protein; K04523 ubiquilin [KO:K04523]
hypothetical protein; K11863 Ataxin-3 [EC:3.4.22.-] [KO:K11863] [EC:3.4.22.-]
hypothetical protein; K10597 ubiquitin conjugation factor E4 B [EC:6.3.2.19] [KO:K10597] [EC:6.3.2.19]
hypothetical protein; K16196 eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1] [KO:K16196] [EC:2.7.11.1]
hypothetical protein; K08852 serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] [KO:K08852] [EC:3.1.26.- 2.7.11.1]
hypothetical protein; K10661 E3 ubiquitin-protein ligase MARCH6 [EC:6.3.2.19] [KO:K10661] [EC:6.3.2.19]
hypothetical protein; K10578 ubiquitin-conjugating enzyme E2 J1 [EC:6.3.2.19] [KO:K10578] [EC:6.3.2.19]
hypothetical protein; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19] [KO:K10575] [EC:6.3.2.19]
hypothetical protein; K04555 ubiquitin-conjugating enzyme E2 G2 [EC:6.3.2.19] [KO:K04555] [EC:6.3.2.19]
hypothetical protein; K14022 coupling of ubiquitin conjugation to ER degradation protein 1 [KO:K14022]
hypothetical protein; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
hypothetical protein; K14026 SEL1 protein [KO:K14026]
UBC1.COLGL (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Colletotrichum hard-surface-induced protein 1); K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
hypothetical protein; K03868 RING-box protein 1 [KO:K03868]
hypothetical protein; K03347 cullin 1 [KO:K03347]
hypothetical protein; K03094 S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  
Calcium cation
G00009  
 
G00010  
 
G00011  
 
G00012  
 
G10694  
 
Reference
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
Reference
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
Reference
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
Reference
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
Reference
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
KO pathway
 
DBGET integrated database retrieval system