KEGG   PATHWAY: uma04145
Entry
uma04145                    Pathway                                
Name
Phagosome - Ustilago maydis
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
uma04145  Phagosome
uma04145

Other DBs
GO: 0045335
Organism
Ustilago maydis [GN:uma]
Gene
UMAG_00340  hypothetical protein [KO:K08492]
UMAG_11027  putative synaptobrevin (V-SNARE) [KO:K08517]
UMAG_02485  putative GTP-binding protein ypt5 [KO:K07889]
UMAG_10615  putative rab5-like GTPase involved in vacuolar protein sorting [KO:K07889]
UMAG_00453  hypothetical protein [KO:K00914] [EC:2.7.1.137]
UMAG_03862  hypothetical protein [KO:K12182]
UMAG_10926  putative H+-ATPase V1 domain catalytic subunit [KO:K02145] [EC:7.1.2.2]
UMAG_11698  putative H(+)-transporting V1 sector ATPase subunit B [KO:K02147]
UMAG_04716  putative H(+)-transporting V1 sector ATPase subunit C [KO:K02148]
UMAG_04167  putative vacuolar ATP synthase subunit D [KO:K02149]
UMAG_11520  putative Vacuolar ATP synthase subunit E [KO:K02150]
UMAG_02064  putative H(+)-transporting V1 sector ATPase subunit F [KO:K02151]
UMAG_04345  putative vacuolar atp synthase subunit g (vma-10) [KO:K02152]
UMAG_10280  hypothetical protein [KO:K02153]
UMAG_00630  putative vacuolar (H+)-ATPase [KO:K02154]
UMAG_02782  putative H(+)-transporting V0 sector ATPase subunit d [KO:K02146]
UMAG_05503  hypothetical protein [KO:K02144]
UMAG_00508  putative H(+)-transporting V0 sector ATPase subunit c [KO:K02155]
UMAG_11802  putative H(+)-transporting V0 sector ATPase subunit c'' [KO:K03661]
UMAG_05511  putative Rab family GTPase YPT7 [KO:K07897]
UMAG_04372  cytoplasmic dynein heavy chain 2 [KO:K10413]
UMAG_15045  cytoplasmic dynein heavy chain 1 [KO:K10413]
UMAG_04598  hypothetical protein [KO:K10415]
UMAG_03459  hypothetical protein [KO:K10416]
UMAG_01221  alpha-tubulin [KO:K07374]
UMAG_05828  putative beta-tubulin [KO:K07375]
UMAG_10558  putative tubulin beta chain [KO:K07375]
UMAG_10465  putative phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
UMAG_06239  hypothetical protein [KO:K00921] [EC:2.7.1.150]
UMAG_10195  putative translocon subunit SEC61 [KO:K10956]
UMAG_10035  putative protein transport protein sec61 subunit beta [KO:K09481]
UMAG_11624  hypothetical protein [KO:K07342]
UMAG_10287  putative calnexin [KO:K08054]
UMAG_00774  Rac1 GTP binding protein [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
uma04144  Endocytosis
KO pathway
ko04145   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG GENES (34)   
All databases (35)   

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