KEGG   PATHWAY: vcm00290
Entry
vcm00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Vibrio cholerae O1 M66-2
Class
Metabolism; Amino acid metabolism
Pathway map
vcm00290  Valine, leucine and isoleucine biosynthesis
vcm00290

Module
vcm_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:vcm00290]
vcm_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:vcm00290]
vcm_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:vcm00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Vibrio cholerae O1 M66-2 [GN:vcm]
Gene
VCM66_0027  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
VCM66_2414  leuC; 3-isopropylmalate dehydratase, large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
VCM66_2415  leuD; 3-isopropylmalate dehydratase, small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
VCM66_2413  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
VCM66_2405  ilvI; acetolactate synthase III, large subunit [KO:K01652] [EC:2.2.1.6]
VCM66_0031  ilvG; acetolactate synthase II, large subunit [KO:K01652] [EC:2.2.1.6]
VCM66_1530  alsS; acetolactate synthase [KO:K01652] [EC:2.2.1.6]
VCM66_2404  ilvH; acetolactate synthase III, small subunit [KO:K01653] [EC:2.2.1.6]
VCM66_0030  ilvM; acetolactate synthase II, small subunit [KO:K11258] [EC:2.2.1.6]
VCM66_0161  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
VCM66_0028  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
VCM66_0029  ilvE; branched-chain amino acid amiotransferase [KO:K00826] [EC:2.6.1.42]
VCM66_0019  avtA; valine-pyruvate aminotransferase [KO:K00835] [EC:2.6.1.66]
VCM66_1901  putative aspartate aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
VCM66_2412  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
vcm00260  Glycine, serine and threonine metabolism
vcm00280  Valine, leucine and isoleucine degradation
vcm00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG GENES (15)   
All databases (16)   

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