KEGG   PATHWAY: xax03440Help
Entry
xax03440                    Pathway                                

Name
Homologous recombination - Xanthomonas axonopodis pv. citrumelo F1
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
xax03440  Homologous recombination
xax03440

Ortholog table
Module
xax_M00260  DNA polymerase III complex, bacteria [PATH:xax03440]
Other DBs
BSID: 485774
GO: 0000724
Organism
Xanthomonas axonopodis pv. citrumelo F1 [GN:xax]
Gene
XACM_1893  single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
XACM_2837  single-stranded DNA-binding protein [KO:K03111]
XACM_0004  recF; recombination protein F [KO:K03629]
XACM_1310  recO; DNA repair protein RecO [KO:K03584]
XACM_1078  recR; recombination protein RecR [KO:K06187]
XACM_1761  recA; recombinase A [KO:K03553]
XACM_3977  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
XACM_3069  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
XACM_3066  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
XACM_3070  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
XACM_3279  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
XACM_4219  recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
XACM_4220  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
XACM_4218  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
XACM_1394  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
XACM_0002  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
XACM_1076  dnaX; DNA polymerase III subunit gamma and tau [KO:K02343] [EC:2.7.7.7]
XACM_2720  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
XACM_1097  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
XACM_1048  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
XACM_3452  holC; DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
XACM_3719  priA; primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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