KEGG   PATHWAY: xca00300Help
Entry
xca00300                    Pathway                                

Name
Lysine biosynthesis - Xanthomonas campestris pv. campestris B100
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Lysine biosynthesis
xca00300

All organismsOrtholog table
Module
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:xca00300]
Other DBs
BSID: 
GO: 
Organism
Xanthomonas campestris pv. campestris B100 [GN:xca]
Gene
hypothetical protein; K00003 homoserine dehydrogenase [EC:1.1.1.3] [KO:K00003] [EC:1.1.1.3]
thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:1.1.1.3 2.7.2.4]
bifunctional aspartate kinase/diaminopimelate decarboxylase; K12526 bifunctional diaminopimelate decarboxylase / aspartate kinase [EC:4.1.1.20 2.7.2.4] [KO:K12526] [EC:2.7.2.4 4.1.1.20]
aspartate-semialdehyde dehydrogenase; K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [KO:K00133] [EC:1.2.1.11]
dapA1; dihydrodipicolinate synthase [KO:K01714] [EC:4.3.3.7]
dapA2; dihydrodipicolinate synthase [KO:K01714] [EC:4.3.3.7]
dihydrodipicolinate reductase; K00215 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] [KO:K00215] [EC:1.17.1.8]
dapD; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase [KO:K00674] [EC:2.3.1.117]
argD; acetylornithine transaminase [KO:K00821] [EC:2.6.1.17 2.6.1.11]
succinyl-diaminopimelate desuccinylase; K01439 succinyl-diaminopimelate desuccinylase [EC:3.5.1.18] [KO:K01439] [EC:3.5.1.18]
dapF; diaminopimelate epimerase [KO:K01778] [EC:5.1.1.7]
diaminopimelate decarboxylase; K01586 diaminopimelate decarboxylase [EC:4.1.1.20] [KO:K01586] [EC:4.1.1.20]
aminotransferase; K05825 2-aminoadipate transaminase [EC:2.6.1.-] [KO:K05825] [EC:2.6.1.-]
murE; UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [KO:K01928] [EC:6.3.2.13]
murF; UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase [KO:K01929] [EC:6.3.2.10]
Compound
C00024  
Acetyl-CoA
C00026  
2-Oxoglutarate
C00047  
L-Lysine
C00049  
L-Aspartate
C00263  
L-Homoserine
C00322  
2-Oxoadipate
C00441  
L-Aspartate 4-semialdehyde
C00449  
N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00666  
LL-2,6-Diaminoheptanedioate
C00680  
meso-2,6-Diaminoheptanedioate
C00956  
L-2-Aminoadipate
C01251  
(R)-2-Hydroxybutane-1,2,4-tricarboxylate
C03082  
4-Phospho-L-aspartate
C03871  
L-2-Amino-6-oxoheptanedioate
C03972  
2,3,4,5-Tetrahydrodipicolinate
C04002  
(Z)-But-1-ene-1,2,4-tricarboxylate
C04076  
L-2-Aminoadipate 6-semialdehyde
C04390  
N6-Acetyl-LL-2,6-diaminoheptanedioate
C04421  
N-Succinyl-LL-2,6-diaminoheptanedioate
C04462  
N-Succinyl-2-L-amino-6-oxoheptanedioate
C04877  
UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate
C04882  
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05535  
alpha-Aminoadipoyl-S-acyl enzyme
C05539  
N-Acetyl-L-2-amino-6-oxopimelate
C05560  
L-2-Aminoadipate adenylate
C05662  
Homoisocitrate
C16138  
L-Pyrrolysine
C19886  
LysW-gamma-L-alpha-aminoadipate
C19887  
LysW-gamma-L-alpha-aminoadipyl-6-phosphate
C19888  
LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
C19889  
LysW-gamma-L-lysine
C20258  
(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
C20277  
(2R,3R)-3-Methylornithine
C20278  
(2R,3R)-3-Methylornithinyl-N6-lysine
C20279  
(2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine
Reference
  Authors
Ledwidge R, Blanchard JS.
  Title
The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.
  Journal
Biochemistry 38:3019-3024 (1999)
Reference
  Authors
Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.
  Title
Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.
  Journal
J Bacteriol 182:3626-3631 (2000)
Reference
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat Prod Rep 17:85-97 (2000)
Reference
  Authors
Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
  Title
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
  Journal
Nucleic Acids Res 31:6748-57 (2003)
Reference
  Authors
Velasco AM, Leguina JI, Lazcano A.
  Title
Molecular evolution of the lysine biosynthetic pathways.
  Journal
J Mol Evol 55:445-59 (2002)
Reference
  Authors
Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.
  Title
alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.
  Journal
Microbiology 150:2327-34 (2004)
Reference
  Authors
Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.
  Title
Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
  Journal
Mol Genet Metab 76:172-80 (2002)
Reference
  Authors
Nishiyama M.
  Title
[Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]
  Journal
Tanpakushitsu Kakusan Koso 49:758-63 (2004)
Reference
  Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
  Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  Journal
Genome Res 9:1175-83 (1999)
Reference
  Authors
Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.
  Title
Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.
  Journal
J Mol Biol 332:729-40 (2003)
Reference
  Authors
Hudson AO, Singh BK, Leustek T, Gilvarg C.
  Title
An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.
  Journal
Plant Physiol 140:292-301 (2006)
Reference
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
Reference
  Authors
Dairi T, Kuzuyama T, Nishiyama M, Fujii I
  Title
Convergent strategies in biosynthesis.
  Journal
Nat Prod Rep 28:1054-86 (2011)
Reference
  Authors
Gaston MA, Jiang R, Krzycki JA
  Title
Functional context, biosynthesis, and genetic encoding of pyrrolysine.
  Journal
Curr Opin Microbiol 14:342-9 (2011)
KO pathway
 

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