| Entry |
|
| Name |
Selenocompound metabolism - Xanthomonas campestris pv. campestris B100
|
| Class |
Metabolism; Metabolism of other amino acids
 |
| Pathway map |
| Selenocompound metabolism |

  |
| Organism |
Xanthomonas campestris pv. campestris B100 [GN: xca]
|
| Gene |
| | | metH1; methionine synthase (N-terminal fragment) [KO: K00548] [EC: 2.1.1.13] | | metH2; methionine synthase (C-terminal fragment) [KO: K00548] [EC: 2.1.1.13] | | metE; 5-methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase [KO: K00549] [EC: 2.1.1.14] | | Cys/Met metabolism PLP-dependent enzyme; K01758 cystathionine gamma-lyase [EC: 4.4.1.1] [KO: K01758] [EC: 4.4.1.1] | | | | thioredoxin-disulfide reductase; K00384 thioredoxin reductase (NADPH) [EC: 1.8.1.9] [KO: K00384] [EC: 1.8.1.9] | | | | cysNC; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase [KO: K00955] [EC: 2.7.1.25 2.7.7.4] | | cysD; sulfate adenylyltransferase subunit 2 [KO: K00957] [EC: 2.7.7.4] | | |
|
| Compound |
| Protein | | L-Alanine | | Hydrogen selenide | | Dimethyl selenide | | Selenophosphoric acid | | L-Selenomethionine | | Selenomethionyl-tRNA(Met) | | Selenite | | Adenylylselenate | | L-Selenocysteine | | Se-Methyl-L-selenocysteine | | Se-Methylselenomethionine | | gamma-Glutamyl-Se-methylselenocysteine | | Selenate | | Selenohomocysteine | | L-Selenocystathionine | | Methaneselenol | | L-Seryl-tRNA(Sec) | | L-Selenocysteinyl-tRNA(Sec) | | O-Phosphoseryl-tRNA(Sec) | | Selenodiglutathione | | Glutathioselenol | | Trimethylselenonium | | 1-Methylseleno-N-acetyl-D-galactosamine | | Methylselenic acid | | Methylselenopyruvate | | Methylselenocysteine Se-oxide |
|
| Reference |
|
| Authors |
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L |
| Title |
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture. |
| Journal |
J Nutr Biochem (2010) |
| Reference |
|
| Authors |
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA |
| Title |
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators. |
| Journal |
Transgenic Res 18:407-24 (2009) |
| Reference |
|
| Authors |
Pinto JT, Lee JI, Sinha R, Macewan ME, Cooper AJ |
| Title |
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds. |
| Journal |
Amino Acids (2010) |
| Reference |
|
| Authors |
Suzuki KT, Kurasaki K, Suzuki N |
| Title |
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide. |
| Journal |
Biochim Biophys Acta 1770:1053-61 (2007) |
| Reference |
|
| Authors |
Gromer S, Gross JH |
| Title |
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium. |
| Journal |
J Biol Chem 277:9701-6 (2002) |
| KO pathway |
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