KEGG   PATHWAY: xce03440Help
Entry
xce03440                    Pathway                                

Name
Homologous recombination - Xylanimonas cellulosilytica
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
xce03440  Homologous recombination
xce03440

Ortholog table
Module
xce_M00260  DNA polymerase III complex, bacteria [PATH:xce03440]
Other DBs
BSID: 129697
GO: 0000724
Organism
Xylanimonas cellulosilytica [GN:xce]
Gene
Xcel_3354  single-strand binding protein [KO:K03111]
Xcel_1088  single-strand binding protein [KO:K03111]
Xcel_0004  DNA replication and repair protein RecF [KO:K03629]
Xcel_2177  DNA repair protein RecO [KO:K03584]
Xcel_0272  recombination protein RecR [KO:K06187]
Xcel_1242  recA protein [KO:K03553]
Xcel_2087  DNA-directed DNA polymerase [KO:K02335] [EC:2.7.7.7]
Xcel_1509  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Xcel_1667  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Xcel_1668  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Xcel_1666  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Xcel_2855  putative transcriptional regulator [KO:K03655] [EC:3.6.4.12]
Xcel_2888  putative transcriptional regulator [KO:K03655] [EC:3.6.4.12]
Xcel_3059  putative transcriptional regulator [KO:K03655] [EC:3.6.4.12]
Xcel_2279  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Xcel_1296  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Xcel_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Xcel_0254  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Xcel_2208  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Xcel_0355  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Xcel_0688  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Xcel_2004  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Xcel_2129  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Xcel_1719  Primosomal protein N' (replication factor Y) - superfamily II helicase-like protein [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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