KEGG   PATHWAY: xtr03460Help
Entry
xtr03460                    Pathway                                
Name
Fanconi anemia pathway - Xenopus tropicalis (western clawed frog)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Fanconi anemia pathway
xtr03460

All organismsOrtholog table
Module
DNA polymerase zeta  complex [PATH:xtr03460]
BRCA1-associated genome surveillance complex (BASC) [PATH:xtr03460]
FA core complex [PATH:xtr03460]
Bloom's syndrome complex [PATH:xtr03460]
Other DBs
BSID: 
GO: 
Organism
Xenopus tropicalis (western clawed frog) [GN:xtr]
Gene
atrip; ATR interacting protein [KO:K10905]
serine/threonine-protein kinase atr-like; K06640 serine/threonine-protein kinase ATR [EC:2.7.11.1] [KO:K06640] [EC:2.7.11.1]
Fanconi anemia group M protein-like; K10896 fanconi anemia group M protein [KO:K10896]
Fanconi anemia group M protein-like; K10896 fanconi anemia group M protein [KO:K10896]
548876  
c19orf40; chromosome 19 open reading frame 40 [KO:K10898]
apitd1; apoptosis-inducing, TAF9-like domain 1 [KO:K11511]
centromere protein X-like; K15360 centromere protein X [KO:K15360]
780338  
telo2; TEL2, telomere maintenance 2, homolog [KO:K11137]
496617  
hes1; hairy and enhancer of split 1 [KO:K06054]
394465  
hes4; hairy and enhancer of split 4 [KO:K06054]
Fanconi anemia-associated protein of 100 kDa-like; K10993 fanconi anemia core complex 100 kDa subunit [KO:K10993]
fanca; Fanconi anemia, complementation group A [KO:K10888]
Fanconi anemia group B protein-like; K10889 fanconi anemia group B protein [KO:K10889]
Fanconi anemia group C protein-like; K10890 fanconi anemia group C protein [KO:K10890]
fance; Fanconi anemia, complementation group E [KO:K10892]
fancf; Fanconi anemia, complementation group F [KO:K10893]
fancg; Fanconi anemia, complementation group G [KO:K10894]
493212  
fancl; Fanconi anemia, complementation group L [KO:K10606] [EC:6.3.2.19]
780319  
wdr48; WD repeat domain 48 [KO:K15361]
780036  
usp1; ubiquitin specific peptidase 1 [KO:K11832] [EC:3.1.2.15]
polg; polymerase (DNA directed), gamma [KO:K10895]
fancd2; Fanconi anemia, complementation group D2 [KO:K10891]
brca2; breast cancer 2, early onset [KO:K08775]
uncharacterized LOC100491433; K10897 partner and localizer of BRCA2 [KO:K10897]
548416  
rad51c; RAD51 homolog C [KO:K10870]
549147  
rad51; RAD51 homolog (S. cerevisiae) [KO:K04482]
733513  
brca1; breast cancer 1, early onset [KO:K10605]
brip1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:3.6.4.12]
coiled-coil domain-containing protein MTMR15-like; K15363 fanconi-associated nuclease 1 [KO:K15363]
mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2 [KO:K08734]
pms2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae) [KO:K10858]
DNA repair protein REV1-like; K03515 DNA repair protein REV1 [EC:2.7.7.-] [KO:K03515] [EC:2.7.7.-]
rev3l; REV3-like, polymerase (DNA directed), zeta, catalytic subunit [KO:K02350] [EC:2.7.7.7]
DNA polymerase eta-like; K03509 DNA polymerase eta [EC:2.7.7.7] [KO:K03509] [EC:2.7.7.7]
613070  
poli; polymerase (DNA directed) iota [KO:K03510] [EC:2.7.7.7]
448219  
polk; polymerase (DNA directed) kappa [KO:K03511] [EC:2.7.7.7]
549050  
rmi1; RMI1, RecQ mediated genome instability 1, homolog [KO:K10990]
top3b; topoisomerase (DNA) III beta [KO:K03165] [EC:5.99.1.2]
top3a; topoisomerase (DNA) III alpha [KO:K03165] [EC:5.99.1.2]
blm; Bloom syndrome, RecQ helicase-like [KO:K10901] [EC:3.6.4.12]
548449  
rpa1; replication protein A1, 70kDa [KO:K07466]
448500  
rpa2; replication protein A2, 32kDa [KO:K10739]
549380  
rpa3; replication protein A3, 14kDa [KO:K10740]
496413  
mus81; MUS81 endonuclease homolog [KO:K08991] [EC:3.1.22.-]
779752  
eme1; essential meiotic endonuclease 1 homolog 1 [KO:K10882] [EC:3.1.22.-]
780321  
eme2; essential meiotic endonuclease 1 homolog 2 [KO:K10883]
ercc4; excision repair cross-complementing rodent repair deficiency, complementation group 4 [KO:K10848] [EC:3.1.-.-]
uncharacterized LOC100145222; K10849 DNA excision repair protein ERCC-1 [KO:K10849]
ercc1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) [KO:K10849]
slx1a; SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) [KO:K15078] [EC:3.6.1.-]
slx4; SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) [KO:K10484]
Reference
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
Reference
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
Reference
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
Reference
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
Reference
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
Reference
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
KO pathway
 
DBGET integrated database retrieval system