KEGG   PATHWAY: yep02060Help
Entry
yep02060                    Pathway                                
Name
Phosphotransferase system (PTS) - Yersinia enterocolitica subsp. palearctica 105.5R(r)
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Phosphotransferase system (PTS)
yep02060

All organismsOrtholog table
Module
PTS system, glucose-specific II component [PATH:yep02060]
PTS system, maltose and glucose-specific II component [PATH:yep02060]
PTS system, N-acetylglucosamine-specific II component [PATH:yep02060]
PTS system, arbutin-like II component [PATH:yep02060]
PTS system, sucrose-specific II component [PATH:yep02060]
PTS system, trehalose-specific II component [PATH:yep02060]
PTS system, beta-glucosides-specific II component [PATH:yep02060]
PTS system, arbutin-, cellobiose-, and salicin-specific II component [PATH:yep02060]
PTS system, fructose-specific II component [PATH:yep02060]
PTS system, mannitol-specific II component [PATH:yep02060]
PTS system, cellobiose-specific II component [PATH:yep02060]
PTS system, mannose-specific II component [PATH:yep02060]
PTS system, N-acetylgalactosamine-specific II component [PATH:yep02060]
PTS system, sorbose-specific II component [PATH:yep02060]
PTS system, galactitol-specific II component [PATH:yep02060]
PTS system, glucitol/sorbitol-specific II component [PATH:yep02060]
PTS system, lactose-specific II component [PATH:yep02060]
PTS system, D-glucosamine-specific II component [PATH:yep02060]
PTS system, ascorbate-specific II component [PATH:yep02060]
PTS system, galactosamine-specific II component [PATH:yep02060]
PTS system, N-acetylmuramic acid-specific II component [PATH:yep02060]
PTS system, fructose-specific II component [PATH:yep02060]
PTS system, 2-O-A-mannosyl-D-glycerate-specific II component [PATH:yep02060]
Other DBs
BSID: 
GO: 
TC: 
Organism
Yersinia enterocolitica subsp. palearctica 105.5R(r) [GN:yep]
Gene
phosphoenolpyruvate-protein phosphotransferase; K08483 phosphotransferase system, enzyme I, PtsI [EC:2.7.3.9] [KO:K08483] [EC:2.7.3.9]
phosphohistidinoprotein-hexose phosphotransferase; K02784 phosphocarrier protein HPr [KO:K02784]
glucose-specific PTS system component; K02777 PTS system, glucose-specific IIA component [EC:2.7.1.69] [KO:K02777] [EC:2.7.1.69]
glucose-specific PTS system IIBC components; K02778 PTS system, glucose-specific IIB component [EC:2.7.1.69] K02779 PTS system, glucose-specific IIC component [KO:K02778 K02779] [EC:2.7.1.69]
PTS system N-acetylglucosamine-specific transporter subunit IIABC; K02802 PTS system, N-acetylglucosamine-specific IIA component [EC:2.7.1.69] K02803 PTS system, N-acetylglucosamine-specific IIB component [EC:2.7.1.69] K02804 PTS system, N-acetylglucosamine-specific IIC component [KO:K02802 K02803 K02804] [EC:2.7.1.69 2.7.1.69]
PTS system maltose and glucose-specific transporter subunit IICB; K02790 PTS system, maltose and glucose-specific IIB component [EC:2.7.1.69] K02791 PTS system, maltose and glucose-specific IIC component [KO:K02790 K02791] [EC:2.7.1.69]
PTSsystem sucrose-specific transporter subunit IIBC; K02809 PTS system, sucrose-specific IIB component [EC:2.7.1.69] K02810 PTS system, sucrose-specific IIC component [KO:K02809 K02810] [EC:2.7.1.69]
putative PTS-system permease; K02756 PTS system, beta-glucosides-specific IIB component [EC:2.7.1.69] K02757 PTS system, beta-glucosides-specific IIC component [KO:K02756 K02757] [EC:2.7.1.69]
cellobiose/arbutin/salicin-specific PTS system components IIBC; K02752 PTS system, arbutin-, cellobiose-, and salicin-specific IIB component [EC:2.7.1.69] K02753 PTS system, arbutin-, cellobiose-, and salicin-specific IIC component [KO:K02752 K02753] [EC:2.7.1.69]
trehalose(maltose)-specific PTS system components IIBC; K02818 PTS system, trehalose-specific IIB component [EC:2.7.1.69] K02819 PTS system, trehalose-specific IIC component [KO:K02818 K02819] [EC:2.7.1.69]
N-acetylmuramic acid phosphotransfer permease; K11191 PTS system, N-acetylmuramic acid-specific IIB component [EC:2.7.1.69] K11192 PTS system, N-acetylmuramic acid-specific IIC component [KO:K11191 K11192] [EC:2.7.1.69]
PTS system; K02749 PTS system, arbutin-like IIB component [EC:2.7.1.69] K02750 PTS system, arbutin-like IIC component [KO:K02749 K02750] [EC:2.7.1.69]
putative phosphotransferase protein; K02759 PTS system, cellobiose-specific IIA component [EC:2.7.1.69] [KO:K02759] [EC:2.7.1.69]
putative PTS system protein; K02759 PTS system, cellobiose-specific IIA component [EC:2.7.1.69] [KO:K02759] [EC:2.7.1.69]
PTS system N; K02759 PTS system, cellobiose-specific IIA component [EC:2.7.1.69] [KO:K02759] [EC:2.7.1.69]
pts system; K02760 PTS system, cellobiose-specific IIB component [EC:2.7.1.69] [KO:K02760] [EC:2.7.1.69]
putative exported PTS system protein; K02760 PTS system, cellobiose-specific IIB component [EC:2.7.1.69] [KO:K02760] [EC:2.7.1.69]
PTS system N; K02760 PTS system, cellobiose-specific IIB component [EC:2.7.1.69] [KO:K02760] [EC:2.7.1.69]
putative phosphotransferase protein; K02761 PTS system, cellobiose-specific IIC component [KO:K02761]
putative cellobiose-specific phosphotransferase; K02761 PTS system, cellobiose-specific IIC component [KO:K02761]
putative PTS system protein; K02761 PTS system, cellobiose-specific IIC component [KO:K02761]
PTS system N; K02761 PTS system, cellobiose-specific IIC component [KO:K02761]
PTS system mannitol-specific transporter subunit IIABC; K02798 PTS system, mannitol-specific IIA component [EC:2.7.1.69] K02799 PTS system, mannitol-specific IIB component [EC:2.7.1.69] K02800 PTS system, mannitol-specific IIC component [KO:K02798 K02799 K02800] [EC:2.7.1.69 2.7.1.69]
PTS system mannose-specific transporter subunit IIAB; K02793 PTS system, mannose-specific IIA component [EC:2.7.1.69] K02794 PTS system, mannose-specific IIB component [EC:2.7.1.69] [KO:K02793 K02794] [EC:2.7.1.69 2.7.1.69]
PTS system mannose-specific transporter subunit IIC; K02795 PTS system, mannose-specific IIC component [KO:K02795]
mannose-specific PTS system protein IID; K02796 PTS system, mannose-specific IID component [KO:K02796]
sorbose-specific PTS uptake system component; K02812 PTS system, sorbose-specific IIA component [EC:2.7.1.69] [KO:K02812] [EC:2.7.1.69]
sorbose-specific PTS uptake system component; K02813 PTS system, sorbose-specific IIB component [EC:2.7.1.69] [KO:K02813] [EC:2.7.1.69]
sorbose-specific PTS uptake system component; K02814 PTS system, sorbose-specific IIC component [KO:K02814]
sorbose-specific PTS uptake system; K02815 PTS system, sorbose-specific IID component [KO:K02815]
putative phosphotransferase system protein; K02744 PTS system, N-acetylgalactosamine-specific IIA component [EC:2.7.1.69] [KO:K02744] [EC:2.7.1.69]
N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2; K02745 PTS system, N-acetylgalactosamine-specific IIB component [EC:2.7.1.69] [KO:K02745] [EC:2.7.1.69]
phosphotransferase system PTS; K02746 PTS system, N-acetylgalactosamine-specific IIC component [KO:K02746]
putative PTS system mannose/fructose/N-acetylgalactosamine-specific transporter subunit IID; K02747 PTS system, N-acetylgalactosamine-specific IID component [KO:K02747]
glucitol/sorbitol-specific PTS system component IIA; K02781 PTS system, glucitol/sorbitol-specific IIA component [EC:2.7.1.69] [KO:K02781] [EC:2.7.1.69]
PTS system; K02782 PTS system, glucitol/sorbitol-specific IIB component [EC:2.7.1.69] K02783 PTS system, glucitol/sorbitol-specific IIC component [KO:K02782 K02783] [EC:2.7.1.69]
PTS system glucitol/sorbitol-specific transporter subunit IIc2; K02783 PTS system, glucitol/sorbitol-specific IIC component [KO:K02783]
phosphotransferase enzyme II; K02821 PTS system, ascorbate-specific IIA component [EC:2.7.1.69] [KO:K02821] [EC:2.7.1.69]
phosphotransferase enzyme II; K02822 PTS system, ascorbate-specific IIB component [EC:2.7.1.69] [KO:K02822] [EC:2.7.1.69]
PTS system ascorbate-specific transporter subunit IIC; K03475 PTS system, ascorbate-specific IIC component [KO:K03475]
bifunctional fructose-specific PTS IIA/HPr protein; K02768 PTS system, fructose-specific IIA component [EC:2.7.1.69] K11183 phosphocarrier protein FPr [KO:K02768 K11183] [EC:2.7.1.69]
PTS system fructose-specific transporter subunit IIBC; K02769 PTS system, fructose-specific IIB component [EC:2.7.1.69] K02770 PTS system, fructose-specific IIC component [KO:K02769 K02770] [EC:2.7.1.69]
fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain-containing protein; K08484 phosphotransferase system, enzyme I, PtsP [EC:2.7.3.9] [KO:K08484] [EC:2.7.3.9]
phosphohistidinoprotein-hexose phosphotransferase; K08485 phosphocarrier protein NPr [KO:K08485]
PTS transporter subunit IIA-like nitrogen-regulatory protein PtsN; K02806 PTS system, nitrogen regulatory IIA component [EC:2.7.1.69] [KO:K02806] [EC:2.7.1.69]
Compound
C00022  
Pyruvate
C00031  
D-Glucose
C00072  
Ascorbate
C00074  
Phosphoenolpyruvate
C00089  
Sucrose
C00092  
D-Glucose 6-phosphate
C00095  
D-Fructose
C00140  
N-Acetyl-D-glucosamine
C00159  
D-Mannose
C00185  
Cellobiose
C00208  
Maltose
C00243  
Lactose
C00275  
D-Mannose 6-phosphate
C00329  
D-Glucosamine
C00352  
D-Glucosamine 6-phosphate
C00357  
N-Acetyl-D-glucosamine 6-phosphate
C00392  
Mannitol
C00644  
D-Mannitol 1-phosphate
C00689  
alpha,alpha'-Trehalose 6-phosphate
C00697  
Nitrogen
C00794  
D-Sorbitol
C00963  
beta-D-Glucoside
C01083  
alpha,alpha-Trehalose
C01094  
D-Fructose 1-phosphate
C01096  
Sorbitol 6-phosphate
C01132  
N-Acetyl-D-galactosamine
C01135  
Phospho-beta-D-glucoside
C01451  
Salicin
C01452  
Sorbose
C01697  
Galactitol
C02262  
D-Galactosamine
C02713  
N-Acetylmuramate
C02888  
Sorbose 1-phosphate
C05396  
Lactose 6-phosphate
C05737  
Maltose 6-phosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C06311  
Galactitol 1-phosphate
C06376  
N-Acetyl-D-galactosamine 6-phosphate
C06377  
D-Galactosamine 6-phosphate
C11544  
2(alpha-D-Mannosyl)-D-glycerate
C16186  
L-Ascorbate 6-phosphate
C16688  
Sucrose 6-phosphate
C16698  
N-Acetylmuramic acid 6-phosphate
C16699  
2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
KO pathway
 
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