KEGG   PATHWAY: ypg03440Help
Entry
ypg03440                    Pathway                                

Name
Homologous recombination - Yersinia pestis Angola
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
ypg03440  Homologous recombination
ypg03440

Ortholog table
Module
ypg_M00260  DNA polymerase III complex, bacteria [PATH:ypg03440]
Other DBs
BSID: 62259
GO: 0000724
Organism
Yersinia pestis Angola [GN:ypg]
Gene
YpAngola_A3849  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
YpAngola_A0749  ssb; single-strand binding protein [KO:K03111]
YpAngola_A4175  DNA replication and repair protein recF [KO:K03629]
YpAngola_A3613  recO; DNA repair protein RecO [KO:K03584]
YpAngola_A2891  recR; recombination protein RecR [KO:K06187]
YpAngola_A0901  recA; protein RecA [KO:K03553]
YpAngola_A0023  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
YpAngola_A2421  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
YpAngola_A2420  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
YpAngola_A2423  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
YpAngola_A0041  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
YpAngola_A3231  recB; exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
YpAngola_A3233  recC; exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
YpAngola_A3230  recD; exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
YpAngola_0106  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
YpAngola_A3420  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
YpAngola_A4176  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
YpAngola_A2889  dnaX; DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
YpAngola_A1844  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
YpAngola_A3492  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
YpAngola_A2682  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
YpAngola_A1625  holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
YpAngola_A4046  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
YpAngola_A0839  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
YpAngola_A3812  priA; primosomal protein n' [KO:K04066] [EC:3.6.4.-]
YpAngola_A2885  priC; primosomal replication protein n'' [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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