KEGG   PATHWAY: ypk03440Help
Entry
ypk03440                    Pathway                                

Name
Homologous recombination - Yersinia pestis KIM10+ (biovar Mediaevalis)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
ypk03440

All organismsOrtholog table
Module
DNA polymerase III complex, bacteria [PATH:ypk03440]
Other DBs
BSID: 
GO: 
Organism
Yersinia pestis KIM10+ (biovar Mediaevalis) [GN:ypk]
Gene
y3274  
recJ; ssDNA exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
y0582  
ssb; single-stranded DNA-binding protein [KO:K03111]
y4111  
recF; recombination protein F [KO:K03629]
y1299  
recO; DNA repair protein RecO [KO:K03584]
y1062  
recR; recombination protein RecR [KO:K06187]
y0881  
recA; recombinase A [KO:K03553]
y3811  
polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
y2253  
ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
y2252  
ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
y2254  
ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
y0105  
recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
y3164  
recB; exonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
y3166  
recC; exonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
y3163  
recD; exonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
y3120  
dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
putative DNA polymerase III alpha subunit; K02337 DNA polymerase III subunit alpha [EC:2.7.7.7] [KO:K02337] [EC:2.7.7.7]
y4112  
dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
y1060  
dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
y1182  
holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
y1765  
holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
y3094  
dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
y2525  
holE; DNA polymerase III subunit theta [KO:K02345] [EC:2.7.7.7]
y0745  
holC; DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
y3752  
holD; DNA polymerase III subunit psi [KO:K02344] [EC:2.7.7.7]
y0298  
priA; primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
y1056  
primosomal replication protein n''; K04067 primosomal replication protein N'' [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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