KEGG   PATHWAY: ypk03440Help
Entry
ypk03440                    Pathway                                

Name
Homologous recombination - Yersinia pestis KIM10+ (biovar Mediaevalis)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
ypk03440

All organismsOrtholog table
Module
DNA polymerase III complex, bacteria [PATH:ypk03440]
Other DBs
BSID: 
GO: 
Organism
Yersinia pestis KIM10+ (biovar Mediaevalis) [GN:ypk]
Gene
y3274  
recJ; ssDNA exonuclease [KO:K07462] [EC:3.1.-.-]
y0582  
ssb; ssDNA-binding protein [KO:K03111]
y4111  
recF; ssDNA and dsDNA binding protein [KO:K03629]
y1299  
recO; recO protein [KO:K03584]
y1062  
recR; recombination and repair protein [KO:K06187]
y0881  
recA; DNA-dependent ATPase, DNA- and ATP-dependent coprotease [KO:K03553]
y3811  
polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
y2253  
ruvA; Holliday junction helicase subunit B [KO:K03550] [EC:3.6.4.12]
y2252  
ruvB; Holliday junction helicase subunit A [KO:K03551] [EC:3.6.4.12]
y2254  
ruvC; Holliday junction nuclease [KO:K01159] [EC:3.1.22.4]
y0105  
recG; DNA helicase [KO:K03655] [EC:3.6.4.12]
y3164  
recB; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03582] [EC:3.1.11.5]
y3166  
recC; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03583] [EC:3.1.11.5]
y3163  
recD; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03581] [EC:3.1.11.5]
y3120  
dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
putative DNA polymerase III; K02337 DNA polymerase III subunit alpha [EC:2.7.7.7] [KO:K02337] [EC:2.7.7.7]
y4112  
dnaN; DNA polymerase III, beta-subunit [KO:K02338] [EC:2.7.7.7]
y1060  
dnaX; DNA polymerase III, tau and gamma subunits [KO:K02343] [EC:2.7.7.7]
y1182  
holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
y1765  
holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
y3094  
dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
y2525  
holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
y0745  
holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
y3752  
holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
y0298  
priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
y1056  
putative primosomal replication protein N; K04067 primosomal replication protein N'' [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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