KEGG T01111: PB000415.02.0

Plasmodium berghei: PB000415.02.0

Entry

PB000415.02.0 CDS T01111

Definition

bifunctional dihydrofolate reductase-thymidylate synthase

Orthology

K13998

dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]

Organism

pbe Plasmodium berghei

Pathway

pbe00240	Pyrimidine metabolism
pbe00670	One carbon pool by folate
pbe00790	Folate biosynthesis
pbe01100	Metabolic pathways

Class

Metabolism; Nucleotide metabolism; Pyrimidine metabolism [PATH:pbe00240]
Metabolism; Metabolism of cofactors and vitamins; Folate biosynthesis [PATH:pbe00790]
Metabolism; Metabolism of cofactors and vitamins; One carbon pool by folate [PATH:pbe00670]

SSDB

Motif

Pfam:

Thymidylat_synt DHFR_1 DUF778

Other DBs

NCBI-GI:

68073909

NCBI-GeneID:

3427459

UniProt:

Q4YWH2

AA seq 585 aa
MEDLSETFDIYAICACCKVLNDDEKVRCFNNKTFKGIGNAGVLPWKCNLIDMKYFSSVTS
YINENNYIRLKWKRDKYMEKHNLKNNVELNTNIISSTNNLQNIVVMGKKSWESIPKKFKP
LQNRINIILSRTLKKEDIVNENNNENNNVIIIKSVDDLFPILKCTKYYKCFIIGGSSVYK
EFLDRNLIKKIYFTRINNSYNCDVLFPEINENLFKITSISDVYNSNNTTLDFIIYSKTKE
INPNEEVPNNTFLGVCDEQNKAFDDEDDYTYFSFNKNKENIKKNSEHAHNFKIYNSIKYK
NHHEYQYLNIIYDMIMHGNNQDDRTGGVLSKFGYMMKFNLNEYFPLLTTKKLFIRGIIEE
LLWFIRGETNGNTLLEKNVRIWEANGTREFLDRKLFHREVNDLGPIYGFQWRHFGAEYTD
MHDNYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKL
SCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQAAEFIHVLGNAHVYNNHIESLKIQ
LNRTPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHDKINMDMAA

NT seq 1758 nt +upstreamnt +downstreamnt
atggaagacttatctgaaacattcgatatatatgcaatatgtgcatgttgtaaagttctg
aacgatgatgaaaaggttagatgctttaataataaaacgtttaagggaattggaaatgcg
ggggtgttaccttggaaatgtaatttaatcgatatgaaatattttagttctgtaacatca
tatataaatgaaaataattatataagattgaaatggaaaagagataaatatatggaaaaa
cataatttaaaaaataatgtagaactaaatactaatataatttcttcaactaataattta
caaaatattgtagtaatgggaaaaaaaagttgggaaagtattcccaaaaaatttaaacct
ttacaaaatcgaataaacattattttgtctagaactttgaaaaaagaagatattgtaaac
gaaaataataatgaaaataataatgttattataattaaaagtgtagatgatttatttcct
attttaaaatgcacaaaatattacaaatgttttattatagggggttcgtctgtttataaa
gaatttttagatcgtaatttaataaaaaaaatatattttacaagaataaataattcttat
aattgtgatgttttattcccagaaataaacgaaaatttgtttaaaataacttcaataagt
gatgtatataatagtaacaacacaactttagattttataatttatagtaagacaaaagaa
ataaatccaaatgaggaagtacctaataatacatttttaggtgtatgtgatgaacaaaat
aaagcctttgatgatgaagacgattatacatatttcagtttcaataaaaataaagaaaat
attaaaaaaaattctgaacatgctcataattttaaaatatataatagcataaaatataaa
aatcatcatgaatatcaatatttaaatattatatatgatatgataatgcatggaaataac
caagatgatagaacaggtggtgtgttaagtaaatttggatatatgatgaaatttaattta
aatgaatattttccattattaacaacaaaaaaattatttataagaggtattatcgaagaa
ttattgtggtttataagaggggaaacaaatggaaatactttgttagaaaaaaacgtaaga
atatgggaagctaatggaacaagggaatttttagatagaaaattatttcatagagaagtt
aatgatctcggtccaatttatggatttcaatggaggcattttggtgctgaatatacagat
atgcatgataattataaagacaaaggagttgatcaattaaaaaatattataaatttaatt
aaaaatgatcctacttgtagacgaattattttgtgtgcatggaatgtaaaagatttagat
caaatggcattacctccttgtcatattttatgtcaattttatgtttttgacggaaaatta
tcatgtattatgtatcaaagatcttgtgatttagggcttggggttccattcaatattgct
tcctattctatatttacatatatgatagcacaagtatgtaacttacaggcagctgaattt
atacatgtattgggtaatgctcatgtttataataatcatattgaaagcttaaagattcag
ttaaatagaactccttacccttttcctactcttaaattaaatcctgacattaaaaatatc
gaggattttacaatttctgattttactgttcaaaattatgttcatcacgataaaataaat
atggatatggcagcttaa

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (9)   
   KEGG ENZYME (2)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (35)   

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