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Database: PDB
Entry: 1HAF
LinkDB: 1HAF
Original site: 1HAF 
HEADER    GROWTH FACTOR                           30-NOV-95   1HAF              
TITLE     HEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, MINIMIZED   
TITLE    2 AVERAGE STRUCTURE                                                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HEREGULIN-ALPHA;                                           
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: EPIDERMAL GROWTH FACTOR-LIKE DOMAIN;                       
COMPND   5 SYNONYM: NEU DIFFERENTIATION FACTOR (RAT), ACETYLCHOLINE RECEPTOR    
COMPND   6 INDUCING ACTIVITY (CHICKEN), GLIAL GROWTH FACTOR (HUMAN), NEUREGULIN;
COMPND   7 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    GROWTH FACTOR                                                         
EXPDTA    SOLUTION NMR                                                          
AUTHOR    N.E.JACOBSEN,N.J.SKELTON,W.J.FAIRBROTHER                              
REVDAT   3   23-FEB-22 1HAF    1       REMARK                                   
REVDAT   2   24-FEB-09 1HAF    1       VERSN                                    
REVDAT   1   11-JUL-96 1HAF    0                                                
JRNL        AUTH   N.E.JACOBSEN,N.ABADI,M.X.SLIWKOWSKI,D.REILLY,N.J.SKELTON,    
JRNL        AUTH 2 W.J.FAIRBROTHER                                              
JRNL        TITL   HIGH-RESOLUTION SOLUTION STRUCTURE OF THE EGF-LIKE DOMAIN OF 
JRNL        TITL 2 HEREGULIN-ALPHA.                                             
JRNL        REF    BIOCHEMISTRY                  V.  35  3402 1996              
JRNL        REFN                   ISSN 0006-2960                               
JRNL        PMID   8639490                                                      
JRNL        DOI    10.1021/BI952626L                                            
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   W.E.HOLMES,M.X.SLIWKOWSKI,R.W.AKITA,W.J.HENZEL,J.LEE,        
REMARK   1  AUTH 2 J.W.PARK,D.YANSURA,N.ABADI,H.RAAB,G.D.LEWIS,ET AL.           
REMARK   1  TITL   IDENTIFICATION OF HEREGULIN, A SPECIFIC ACTIVATOR OF         
REMARK   1  TITL 2 P185ERBB2                                                    
REMARK   1  REF    SCIENCE                       V. 256  1205 1992              
REMARK   1  REFN                   ISSN 0036-8075                               
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : AMBER                                                
REMARK   3   AUTHORS     : BIOSYM TECHNOLOGIES                                  
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1HAF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL.                                
REMARK 100 THE DEPOSITION ID IS D_1000173743.                                   
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 293                                
REMARK 210  PH                             : 4.5                                
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : NULL                               
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : NULL                               
REMARK 210  SPECTROMETER FIELD STRENGTH    : NULL                               
REMARK 210  SPECTROMETER MODEL             : NULL                               
REMARK 210  SPECTROMETER MANUFACTURER      : NULL                               
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : NULL                               
REMARK 210   METHOD USED                   : NULL                               
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : NULL                               
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 1                                  
REMARK 210 CONFORMERS, SELECTION CRITERIA  : NULL                               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A  27      -57.84   -150.37                                   
REMARK 500    SER A  30       56.54   -172.13                                   
REMARK 500    PRO A  50      108.54    -53.72                                   
REMARK 500    LYS A  52     -163.98   -101.72                                   
REMARK 500    GLN A  54       73.06    -62.84                                   
REMARK 500    ASN A  55      -41.29   -174.88                                   
REMARK 500    GLU A  60       43.51    -80.23                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1HAE   RELATED DB: PDB                                   
DBREF  1HAF A    1    63  UNP    Q02297   NRG1_HUMAN     176    238             
SEQRES   1 A   63  SER HIS LEU VAL LYS CYS ALA GLU LYS GLU LYS THR PHE          
SEQRES   2 A   63  CYS VAL ASN GLY GLY GLU CYS PHE MET VAL LYS ASP LEU          
SEQRES   3 A   63  SER ASN PRO SER ARG TYR LEU CYS LYS CYS GLN PRO GLY          
SEQRES   4 A   63  PHE THR GLY ALA ARG CYS THR GLU ASN VAL PRO MET LYS          
SEQRES   5 A   63  VAL GLN ASN GLN GLU LYS ALA GLU GLU LEU TYR                  
HELIX    1   1 GLU A    8  PHE A   13  1                                   6    
SHEET    1   A 3 HIS A   2  LYS A   5  0                                        
SHEET    2   A 3 GLU A  19  LYS A  24 -1  N  LYS A  24   O  HIS A   2           
SHEET    3   A 3 TYR A  32  LYS A  35 -1  N  LYS A  35   O  GLU A  19           
SSBOND   1 CYS A    6    CYS A   20                          1555   1555  2.06  
SSBOND   2 CYS A   14    CYS A   34                          1555   1555  2.05  
SSBOND   3 CYS A   36    CYS A   45                          1555   1555  2.04  
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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