GenomeNet

Database: PDB
Entry: 1L3N
LinkDB: 1L3N
Original site: 1L3N 
HEADER    OXIDOREDUCTASE                          28-FEB-02   1L3N              
TITLE     THE SOLUTION STRUCTURE OF REDUCED DIMERIC COPPER ZINC SOD:            
TITLE    2 THE STRUCTURAL EFFECTS OF DIMERIZATION                               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: SUPEROXIDE DISMUTASE [CU-ZN];                              
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: SOD;                                                        
COMPND   5 EC: 1.15.1.1;                                                        
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: SOD1;                                                          
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: TOPP1;                                     
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PBR322                                    
KEYWDS    REDUCED HUMAN COPPER/ZINC SUPEROXIDE DISMUTASE, SOLUTION              
KEYWDS   2 STRUCTURE, NMR, HOMODIMERIC PROTEIN., OXIDOREDUCTASE                 
EXPDTA    SOLUTION NMR                                                          
NUMMDL    30                                                                    
AUTHOR    L.BANCI,I.BERTINI,F.CRAMARO,R.DEL CONTE,M.S.VIEZZOLI                  
REVDAT   3   24-FEB-09 1L3N    1       VERSN                                    
REVDAT   2   01-APR-03 1L3N    1       JRNL                                     
REVDAT   1   08-MAY-02 1L3N    0                                                
JRNL        AUTH   L.BANCI,I.BERTINI,F.CRAMARO,R.DEL CONTE,                     
JRNL        AUTH 2 M.S.VIEZZOLI                                                 
JRNL        TITL   THE SOLUTION STRUCTURE OF REDUCED DIMERIC COPPER             
JRNL        TITL 2 ZINC SUPEROXIDE DISMUTASE. THE STRUCTURAL EFFECTS            
JRNL        TITL 3 OF DIMERIZATION                                              
JRNL        REF    EUR.J.BIOCHEM.                V. 269  1905 2002              
JRNL        REFN                   ISSN 0014-2956                               
JRNL        PMID   11952792                                                     
JRNL        DOI    10.1046/J.1432-1033.2002.02840.X                             
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   L.BANCI,I.BERTINI,F.CRAMARO,R.DEL CONTE,A.ROSATO,            
REMARK   1  AUTH 2 M.S.VIEZZOLI                                                 
REMARK   1  TITL   BACKBONE DYNAMICS OF HUMAN CU,ZN SUPEROXIDE                  
REMARK   1  TITL 2 DISMUTASE AND OF ITS MONOMERIC F50E/G51E/E133Q               
REMARK   1  TITL 3 MUTANT: THE INFLUENCE OF DIMERIZATION ON MOBILITY            
REMARK   1  TITL 4 AND FUNCTION                                                 
REMARK   1  REF    BIOCHEMISTRY                  V.  39  9108 2000              
REMARK   1  REFN                   ISSN 0006-2960                               
REMARK   1  DOI    10.1021/BI000067Z                                            
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : AMBER                                                
REMARK   3   AUTHORS     : PEARLMAN ET AL.                                      
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: THE STRUCTURES WERE CALCULATED USING      
REMARK   3  THE CONSTRAINTS: 3566 NOE CROSS PEAKS WERE CONVERTED INTO           
REMARK   3  DISTANCE CONSTRAINTS, 49 DIHEDRAL PHI ANGLES, 52 DIHEDRAL PSI       
REMARK   3  ANGLES, 14 CHI ANGLES AND 45 PROTON PAIRS STEREOSPECIFICALLY        
REMARK   3  ASSIGNED. THE CU(I) AND ZN(II) METAL IONS WERE INCLUDED IN THE      
REMARK   3  CALCULATION WITH SPECIAL LINKERS. THE DISULFIDE BRIDGE BETWEEN      
REMARK   3  CYS57 AND CYS146 WAS INTRODUCED WITH UPPER AND LOWER DISTANCE       
REMARK   3  LIMITS BETWEEN THE CB AND SG ATOMS OF THE TWO SIDE CHAINS.          
REMARK   4                                                                      
REMARK   4 1L3N COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 04-MAR-02.                  
REMARK 100 THE RCSB ID CODE IS RCSB015613.                                      
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 296; 286                           
REMARK 210  PH                             : 5.0; 5.0                           
REMARK 210  IONIC STRENGTH                 : NULL; NULL                         
REMARK 210  PRESSURE                       : 1 ATM; 1 ATM                       
REMARK 210  SAMPLE CONTENTS                : CU(I),ZN(II) SOD 2MM ENRICHED      
REMARK 210                                   IN 15N; CU(I),ZN(II) SOD 2MM       
REMARK 210                                   ENRICHED IN 15N, 13C; CU(I),       
REMARK 210                                   ZN(II) SOD 2MM ENRICHED IN         
REMARK 210                                   15N, 13C AND 2H AT 70%; CU(I),     
REMARK 210                                   ZN(II) SOD 2MM ENRICHED IN 15N     
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : 3D HNCA, 3D NH(CO)CA, 3D           
REMARK 210                                   HNCO, 3D HN(CA)CO-TROSY LIKE,      
REMARK 210                                   2D 15N-HSQC, 2D 13C-HSQC, 3D       
REMARK 210                                   13C-NOESY-HSQC, 3D H(C)CH-         
REMARK 210                                   TOCSY, 3D (H)CCH-TOCSY, 3D 15N     
REMARK 210                                   -NOESY-HSQC, 3D HNHA, 3D HNHB,     
REMARK 210                                   2D NOESY                           
REMARK 210  SPECTROMETER FIELD STRENGTH    : 800 MHZ, 700 MHZ, 600 MHZ          
REMARK 210  SPECTROMETER MODEL             : AVANCE                             
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : CALIBA, GLOMSA, DYANA,             
REMARK 210                                   XWINNMR, PROCHECK-NMR              
REMARK 210   METHOD USED                   : SIMULATED ANNEALING AND            
REMARK 210                                   RESTRAINED ENEGY MINIMIZATION      
REMARK 210                                   IN VACUUM                          
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 1400                               
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 30                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : STRUCTURE WITH THE LOWEST          
REMARK 210                                   ENERGY TARGET FUNCTION             
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: CU(I), ZN(II) SOD STRUCTURE WAS DETERMINED USING TRIPLE      
REMARK 210  RESONANCE THREE-AND BI-DIMENSIONAL AND HOMONUCLEAR BI-              
REMARK 210  DIMENSIONAL TECHNIQUES.                                             
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500 11 ARG A 143   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES          
REMARK 500 11 ARG B 143   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500 12 ARG B 143   NE  -  CZ  -  NH1 ANGL. DEV. =   4.0 DEGREES          
REMARK 500 14 CYS A  57   CA  -  CB  -  SG  ANGL. DEV. =   7.5 DEGREES          
REMARK 500 14 CYS A 146   CA  -  CB  -  SG  ANGL. DEV. =   7.5 DEGREES          
REMARK 500 14 ARG B 115   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500 17 ARG B  69   NE  -  CZ  -  NH1 ANGL. DEV. =   3.6 DEGREES          
REMARK 500 17 ARG B  69   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500 19 ARG A 115   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.8 DEGREES          
REMARK 500 24 ARG B 143   NE  -  CZ  -  NH1 ANGL. DEV. =   3.9 DEGREES          
REMARK 500 27 ARG B 143   NE  -  CZ  -  NH1 ANGL. DEV. =   4.0 DEGREES          
REMARK 500 28 ARG A 143   NE  -  CZ  -  NH1 ANGL. DEV. =   3.0 DEGREES          
REMARK 500 28 CYS B 146   CA  -  CB  -  SG  ANGL. DEV. =   7.3 DEGREES          
REMARK 500 29 ARG B  69   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.3 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 THR A   2      -41.08   -166.22                                   
REMARK 500  1 VAL A  14       97.30    -63.94                                   
REMARK 500  1 ILE A  17       83.69   -156.47                                   
REMARK 500  1 VAL A  31       59.14    -97.31                                   
REMARK 500  1 HIS A  48      161.96     57.10                                   
REMARK 500  1 THR A  58      -54.61   -157.66                                   
REMARK 500  1 ALA A  60      -38.47    -30.26                                   
REMARK 500  1 PRO A  62     -167.13    -79.29                                   
REMARK 500  1 SER A  68      100.85    -58.63                                   
REMARK 500  1 ARG A  69      -90.47   -113.78                                   
REMARK 500  1 PRO A  74        1.26    -68.83                                   
REMARK 500  1 ARG A  79      138.46    -33.45                                   
REMARK 500  1 VAL A  81       39.32    -72.85                                   
REMARK 500  1 SER A  98       71.28   -154.52                                   
REMARK 500  1 SER A 102       57.09   -110.96                                   
REMARK 500  1 VAL A 103      -61.73   -141.77                                   
REMARK 500  1 LYS A 136      -81.17   -118.60                                   
REMARK 500  1 ASN A 139       36.87    178.71                                   
REMARK 500  1 ILE A 149      -86.79    -76.66                                   
REMARK 500  1 ILE A 151      152.64     63.80                                   
REMARK 500  1 ASP B  52      124.00    -24.12                                   
REMARK 500  1 ALA B  60        2.01    -51.35                                   
REMARK 500  1 SER B  68      102.41    -58.39                                   
REMARK 500  1 ARG B  69      -87.88   -132.48                                   
REMARK 500  1 PRO B  74       10.12    -69.11                                   
REMARK 500  1 VAL B  81      -69.76   -174.20                                   
REMARK 500  1 SER B  98       57.40   -158.69                                   
REMARK 500  1 VAL B 103      -51.99   -148.00                                   
REMARK 500  1 LYS B 128       48.77    -82.21                                   
REMARK 500  1 ASN B 139       17.35     56.09                                   
REMARK 500  2 THR A   2      -23.95    125.01                                   
REMARK 500  2 ASN A  53       15.60   -153.82                                   
REMARK 500  2 CYS A  57       60.27     15.36                                   
REMARK 500  2 THR A  58      -61.77   -132.18                                   
REMARK 500  2 ARG A  69      -96.27   -122.92                                   
REMARK 500  2 VAL A  81      -87.35   -160.48                                   
REMARK 500  2 ASP A  90      172.09    -59.63                                   
REMARK 500  2 SER A  98       58.85   -158.05                                   
REMARK 500  2 SER A 107     -165.58   -120.10                                   
REMARK 500  2 ASP A 109      -57.54     71.07                                   
REMARK 500  2 SER A 111       85.05     39.84                                   
REMARK 500  2 LYS A 136      -75.84   -111.50                                   
REMARK 500  2 ARG A 143       68.01    -66.46                                   
REMARK 500  2 ILE A 149      -87.70    -65.81                                   
REMARK 500  2 THR B   2      -46.88   -166.38                                   
REMARK 500  2 VAL B  14       99.74    -68.71                                   
REMARK 500  2 GLN B  22       86.90   -158.84                                   
REMARK 500  2 GLU B  49     -113.68      4.00                                   
REMARK 500  2 PHE B  50     -141.88    -95.29                                   
REMARK 500  2 ASN B  53       12.07   -163.45                                   
REMARK 500  2 THR B  58      -51.05   -156.14                                   
REMARK 500  2 PRO B  62       42.49    -87.84                                   
REMARK 500  2 PHE B  64       70.27    -69.37                                   
REMARK 500  2 SER B  68       99.51    -56.24                                   
REMARK 500  2 ARG B  69      -89.89   -127.48                                   
REMARK 500  2 PRO B  74       15.26    -69.12                                   
REMARK 500  2 VAL B  81      -60.95   -172.35                                   
REMARK 500  2 SER B  98       57.11   -158.62                                   
REMARK 500  2 VAL B 103      -51.16   -143.22                                   
REMARK 500  2 ASP B 109      -48.66   -161.42                                   
REMARK 500  2 SER B 111       75.10     33.65                                   
REMARK 500  2 ILE B 112       44.38    -75.01                                   
REMARK 500  2 LEU B 126       65.34     62.94                                   
REMARK 500  2 ASN B 139       39.06   -154.93                                   
REMARK 500  2 ARG B 143       75.32    -65.15                                   
REMARK 500  3 VAL A  14       94.24    -65.61                                   
REMARK 500  3 ASP A  52      126.86    -36.35                                   
REMARK 500  3 CYS A  57        6.52     59.84                                   
REMARK 500  3 ALA A  60      -25.20    -31.78                                   
REMARK 500  3 PRO A  62       73.25    -69.16                                   
REMARK 500  3 PHE A  64       48.66    -74.29                                   
REMARK 500  3 SER A  68      102.50    -59.10                                   
REMARK 500  3 ARG A  69      -89.90   -105.36                                   
REMARK 500  3 ARG A  79      129.83    -28.76                                   
REMARK 500  3 VAL A  81       89.54    -59.50                                   
REMARK 500  3 SER A  98       69.74   -159.72                                   
REMARK 500  3 SER A 102       56.04    -95.47                                   
REMARK 500  3 VAL A 103      -53.18   -144.12                                   
REMARK 500  3 SER A 111       89.81     38.71                                   
REMARK 500  3 LYS A 136      -83.02   -121.55                                   
REMARK 500  3 ASN A 139       34.08   -173.22                                   
REMARK 500  3 ARG A 143       74.18    -63.54                                   
REMARK 500  3 LYS B  23       86.47   -155.21                                   
REMARK 500  3 ASN B  53       23.56   -153.29                                   
REMARK 500  3 CYS B  57       55.55     33.45                                   
REMARK 500  3 THR B  58      -54.81   -156.30                                   
REMARK 500  3 ALA B  60        8.31    -60.37                                   
REMARK 500  3 HIS B  63       43.29     70.52                                   
REMARK 500  3 PHE B  64       45.89    -73.95                                   
REMARK 500  3 SER B  68      108.82    -54.20                                   
REMARK 500  3 ARG B  69      -91.74   -120.61                                   
REMARK 500  3 ARG B  79      137.32    -38.80                                   
REMARK 500  3 VAL B  81      -61.23   -154.10                                   
REMARK 500  3 ASP B  83       85.50     39.29                                   
REMARK 500  3 SER B  98       72.29   -158.91                                   
REMARK 500  3 ASP B 109      -51.90   -154.72                                   
REMARK 500  3 SER B 111      -59.77     65.42                                   
REMARK 500  3 ILE B 112      -40.22     78.68                                   
REMARK 500  3 ILE B 113      127.50    -24.23                                   
REMARK 500  3 ARG B 143       73.02    -66.01                                   
REMARK 500  3 ALA B 152      -52.63   -128.03                                   
REMARK 500  4 THR A   2      -42.97   -166.84                                   
REMARK 500  4 GLU A  24     -156.88   -121.78                                   
REMARK 500  4 HIS A  48      165.18     61.09                                   
REMARK 500  4 ASP A  52      122.82    -34.65                                   
REMARK 500  4 CYS A  57       49.56    -74.69                                   
REMARK 500  4 THR A  58      -45.83   -137.58                                   
REMARK 500  4 ALA A  60      -42.01    -23.89                                   
REMARK 500  4 HIS A  63      -65.93     65.60                                   
REMARK 500  4 PHE A  64       23.40     36.08                                   
REMARK 500  4 ASN A  65      158.13    -49.72                                   
REMARK 500  4 SER A  68       72.70    -66.30                                   
REMARK 500  4 ARG A  69      -91.37    -92.16                                   
REMARK 500  4 PRO A  74       10.08    -65.51                                   
REMARK 500  4 ARG A  79      133.92    -35.54                                   
REMARK 500  4 HIS A  80      -79.70    -61.50                                   
REMARK 500  4 VAL A  81      -91.42   -130.45                                   
REMARK 500  4 SER A  98       59.72   -156.93                                   
REMARK 500  4 VAL A 103       20.41   -149.27                                   
REMARK 500  4 ASP A 109      -50.98   -121.96                                   
REMARK 500  4 LYS A 128       36.09    -78.75                                   
REMARK 500  4 ASN A 139       37.93   -172.34                                   
REMARK 500  4 ARG A 143       74.79    -66.68                                   
REMARK 500  4 ALA A 152     -106.59   -118.95                                   
REMARK 500  4 THR B   2      -51.81   -145.40                                   
REMARK 500  4 GLU B  24     -144.81   -130.21                                   
REMARK 500  4 ASN B  53       30.56   -165.30                                   
REMARK 500  4 THR B  58      -52.53   -153.38                                   
REMARK 500  4 ALA B  60      -38.88    -26.80                                   
REMARK 500  4 PHE B  64       71.78    -66.84                                   
REMARK 500  4 SER B  68       99.87    -40.28                                   
REMARK 500  4 HIS B  71       93.40     18.00                                   
REMARK 500  4 PRO B  74        6.45    -63.88                                   
REMARK 500  4 GLU B  78       33.51    -80.87                                   
REMARK 500  4 VAL B  81      -58.72   -164.45                                   
REMARK 500  4 SER B  98       56.20   -157.92                                   
REMARK 500  4 VAL B 103      -48.34   -155.38                                   
REMARK 500  4 ASP B 109      -51.10   -156.99                                   
REMARK 500  4 SER B 111       79.14     28.73                                   
REMARK 500  4 ILE B 112       49.69    -69.83                                   
REMARK 500  4 LYS B 128       44.28    -78.24                                   
REMARK 500  4 THR B 137       31.18   -140.05                                   
REMARK 500  4 ALA B 140        0.78    -68.37                                   
REMARK 500  4 ARG B 143       67.59    -67.04                                   
REMARK 500  5 THR A   2      -44.29   -156.35                                   
REMARK 500  5 ILE A  17       84.56   -150.22                                   
REMARK 500  5 ASN A  53       21.10   -141.51                                   
REMARK 500  5 CYS A  57       55.23   -155.19                                   
REMARK 500  5 THR A  58      -46.47   -134.62                                   
REMARK 500  5 PRO A  62     -164.86    -79.39                                   
REMARK 500  5 HIS A  63       46.54    -80.25                                   
REMARK 500  5 ARG A  69      -98.66   -105.82                                   
REMARK 500  5 PRO A  74       16.27    -69.73                                   
REMARK 500  5 ARG A  79      129.17    -34.69                                   
REMARK 500  5 VAL A  81       15.04    -63.55                                   
REMARK 500  5 SER A  98       62.41   -158.64                                   
REMARK 500  5 LYS A 136      -60.88   -103.17                                   
REMARK 500  5 ASN A 139       40.21   -165.38                                   
REMARK 500  5 ARG A 143       64.11    -67.95                                   
REMARK 500  5 ALA A 152     -109.15   -123.88                                   
REMARK 500  5 VAL B  14       99.49    -66.33                                   
REMARK 500  5 GLU B  24     -130.60   -123.57                                   
REMARK 500  5 ASP B  52      101.31    -29.48                                   
REMARK 500  5 CYS B  57       66.85     19.55                                   
REMARK 500  5 THR B  58      -52.09   -151.38                                   
REMARK 500  5 PHE B  64       71.47    -68.66                                   
REMARK 500  5 LEU B  67      -96.50     49.52                                   
REMARK 500  5 SER B  68       94.80    172.59                                   
REMARK 500  5 HIS B  71       96.10    -10.17                                   
REMARK 500  5 PRO B  74       11.39    -67.45                                   
REMARK 500  5 VAL B  81      -51.92   -162.98                                   
REMARK 500  5 SER B  98       66.94   -155.15                                   
REMARK 500  5 SER B 102       56.75   -108.79                                   
REMARK 500  5 VAL B 103      -61.62   -147.57                                   
REMARK 500  5 ASP B 109      -51.73   -164.01                                   
REMARK 500  5 SER B 111       70.85     49.83                                   
REMARK 500  5 LEU B 126     -146.42     59.79                                   
REMARK 500  5 ASN B 139       19.61     57.78                                   
REMARK 500  5 ARG B 143       71.14    -67.22                                   
REMARK 500  6 ASN A  53       18.15   -166.49                                   
REMARK 500  6 CYS A  57       60.78     37.27                                   
REMARK 500  6 THR A  58      -48.06   -157.76                                   
REMARK 500  6 ALA A  60      -36.31    -30.28                                   
REMARK 500  6 PRO A  62     -162.77    -79.91                                   
REMARK 500  6 PRO A  66       47.77    -79.21                                   
REMARK 500  6 LEU A  67       49.66   -163.79                                   
REMARK 500  6 SER A  68      108.37    -52.98                                   
REMARK 500  6 HIS A  71      116.29    -36.05                                   
REMARK 500  6 ARG A  79      139.00    -34.94                                   
REMARK 500  6 HIS A  80     -100.63    -71.22                                   
REMARK 500  6 VAL A  81       30.13   -148.30                                   
REMARK 500  6 SER A  98       75.91   -159.53                                   
REMARK 500  6 VAL A 103      -44.57   -138.62                                   
REMARK 500  6 ASP A 109      -50.90   -166.89                                   
REMARK 500  6 ILE A 112       32.07    -74.57                                   
REMARK 500  6 LEU A 126       47.57     36.43                                   
REMARK 500  6 LYS A 128       44.27    -83.23                                   
REMARK 500  6 ASN A 139       32.88   -173.12                                   
REMARK 500  6 ARG A 143       65.72    -65.05                                   
REMARK 500  6 LYS B  23       40.27   -154.95                                   
REMARK 500  6 CYS B  57       54.85     16.88                                   
REMARK 500  6 THR B  58      -56.25   -125.97                                   
REMARK 500  6 ALA B  60      -31.50    -34.14                                   
REMARK 500  6 PRO B  62     -179.27    -64.51                                   
REMARK 500  6 LEU B  67     -101.06     62.46                                   
REMARK 500  6 SER B  68       97.45    171.59                                   
REMARK 500  6 LYS B  70       55.32   -113.44                                   
REMARK 500  6 HIS B  71       88.20     47.05                                   
REMARK 500  6 VAL B  81      -47.09   -165.50                                   
REMARK 500  6 VAL B 103      -50.53   -151.16                                   
REMARK 500  6 LEU B 106       -4.34    -59.23                                   
REMARK 500  6 ASP B 109      -53.83   -135.81                                   
REMARK 500  6 HIS B 110       36.72    -80.67                                   
REMARK 500  6 ILE B 113      -73.26    -58.49                                   
REMARK 500  6 LYS B 128       44.97    -78.19                                   
REMARK 500  7 THR A   2      -41.06    169.26                                   
REMARK 500  7 VAL A  14       95.89    -64.75                                   
REMARK 500  7 CYS A  57       43.29   -170.78                                   
REMARK 500  7 ALA A  60      -32.10    -37.16                                   
REMARK 500  7 SER A  68       95.64    -58.97                                   
REMARK 500  7 ARG A  69      -96.57   -110.59                                   
REMARK 500  7 HIS A  80      -77.64    -71.88                                   
REMARK 500  7 VAL A  81       58.02   -161.41                                   
REMARK 500  7 SER A  98       66.95   -156.93                                   
REMARK 500  7 SER A 102       42.75    -95.96                                   
REMARK 500  7 VAL A 103      -49.88   -155.30                                   
REMARK 500  7 SER A 105       94.22   -164.66                                   
REMARK 500  7 LEU A 106       27.48    -68.61                                   
REMARK 500  7 ASP A 109      -50.14   -165.75                                   
REMARK 500  7 ILE A 112       46.77    -74.62                                   
REMARK 500  7 ASP A 125       25.04    -78.14                                   
REMARK 500  7 LEU A 126       45.82     30.53                                   
REMARK 500  7 LYS A 136      -82.09   -112.69                                   
REMARK 500  7 ARG A 143       71.97    -65.94                                   
REMARK 500  7 ILE A 149      -90.95    -71.45                                   
REMARK 500  7 GLU B  24     -136.60   -129.97                                   
REMARK 500  7 GLU B  49      -83.96     22.50                                   
REMARK 500  7 ASP B  52      130.24    -37.47                                   
REMARK 500  7 CYS B  57       61.60      3.94                                   
REMARK 500  7 THR B  58      -60.03   -135.33                                   
REMARK 500  7 HIS B  63      -44.31     75.57                                   
REMARK 500  7 PHE B  64       59.40     31.13                                   
REMARK 500  7 SER B  68       77.31    -18.35                                   
REMARK 500  7 HIS B  71       89.19     12.83                                   
REMARK 500  7 PRO B  74       12.13    -66.72                                   
REMARK 500  7 VAL B  81      -69.45   -174.42                                   
REMARK 500  7 SER B  98       74.58   -155.46                                   
REMARK 500  7 LEU B 126       64.54     62.45                                   
REMARK 500  7 LYS B 136      -59.44   -127.05                                   
REMARK 500  7 THR B 137       22.42   -140.63                                   
REMARK 500  7 ASN B 139       42.19   -163.62                                   
REMARK 500  8 THR A   2      -49.09   -133.81                                   
REMARK 500  8 HIS A  48      144.45     63.64                                   
REMARK 500  8 ASN A  53      -64.41   -146.34                                   
REMARK 500  8 THR A  54      -57.17     46.54                                   
REMARK 500  8 CYS A  57       39.35    -78.80                                   
REMARK 500  8 HIS A  63       36.20     71.82                                   
REMARK 500  8 ARG A  69      -87.91   -116.80                                   
REMARK 500  8 PRO A  74       10.58    -65.98                                   
REMARK 500  8 VAL A  81      -64.63   -167.37                                   
REMARK 500  8 ASP A  90      170.97    -59.38                                   
REMARK 500  8 SER A  98       59.21   -156.62                                   
REMARK 500  8 ASP A 109      -51.36   -163.37                                   
REMARK 500  8 SER A 111       81.47     22.86                                   
REMARK 500  8 ILE A 112       39.23    -75.93                                   
REMARK 500  8 LYS A 136      -94.39   -122.38                                   
REMARK 500  8 ASN A 139       35.97   -162.27                                   
REMARK 500  8 ARG A 143       74.84    -66.76                                   
REMARK 500  8 ILE A 149      -86.88    -68.36                                   
REMARK 500  8 HIS B  48      175.22     62.39                                   
REMARK 500  8 ASN B  53       16.66   -153.79                                   
REMARK 500  8 CYS B  57       18.31   -157.84                                   
REMARK 500  8 ALA B  60      -42.53    -24.46                                   
REMARK 500  8 PRO B  62     -169.29    -74.42                                   
REMARK 500  8 SER B  68      107.61    -39.36                                   
REMARK 500  8 LYS B  70       57.88   -117.64                                   
REMARK 500  8 HIS B  71       94.97     38.03                                   
REMARK 500  8 PRO B  74       10.32    -69.81                                   
REMARK 500  8 VAL B  81      -66.84   -165.02                                   
REMARK 500  8 SER B  98       75.80   -158.85                                   
REMARK 500  8 ASP B 109      -53.00   -152.17                                   
REMARK 500  8 SER B 111       71.74     43.09                                   
REMARK 500  8 ILE B 112        1.53    -66.40                                   
REMARK 500  8 LYS B 128       42.39    -77.91                                   
REMARK 500  8 ARG B 143       78.86    -64.02                                   
REMARK 500  9 ILE A  17       59.68   -140.82                                   
REMARK 500  9 GLN A  22       83.23   -155.61                                   
REMARK 500  9 GLU A  49     -157.51     50.30                                   
REMARK 500  9 CYS A  57       33.16    -80.23                                   
REMARK 500  9 THR A  58      -57.72   -125.24                                   
REMARK 500  9 HIS A  63       79.86    -66.87                                   
REMARK 500  9 PHE A  64       53.93   -105.85                                   
REMARK 500  9 SER A  68      104.79    -58.74                                   
REMARK 500  9 PRO A  74       16.09    -68.36                                   
REMARK 500  9 ARG A  79      118.95    -35.65                                   
REMARK 500  9 VAL A  81      -46.91   -178.25                                   
REMARK 500  9 SER A  98       58.40   -158.88                                   
REMARK 500  9 VAL A 103      -52.73   -149.01                                   
REMARK 500  9 ASP A 109      -51.74   -161.02                                   
REMARK 500  9 SER A 111       74.86     35.53                                   
REMARK 500  9 ILE A 112       46.54    -76.36                                   
REMARK 500  9 ILE A 113      -86.96    -92.31                                   
REMARK 500  9 LEU A 126       53.62     76.07                                   
REMARK 500  9 LYS A 136      -68.38   -109.36                                   
REMARK 500  9 ARG A 143       89.11    -64.03                                   
REMARK 500  9 VAL B  14       95.70    -67.06                                   
REMARK 500  9 LYS B  23      -77.13    -76.04                                   
REMARK 500  9 GLU B  24     -125.90    -99.98                                   
REMARK 500  9 GLU B  40      156.84    -46.57                                   
REMARK 500  9 VAL B  47       79.10   -116.69                                   
REMARK 500  9 ASP B  52      175.88    -52.57                                   
REMARK 500  9 ASN B  53       31.82   -149.99                                   
REMARK 500  9 THR B  58      -54.32   -134.30                                   
REMARK 500  9 SER B  59       34.31    -90.56                                   
REMARK 500  9 PHE B  64       79.21    -67.89                                   
REMARK 500  9 PRO B  66       40.30    -79.56                                   
REMARK 500  9 LEU B  67       37.68   -162.84                                   
REMARK 500  9 SER B  68      100.05    -42.31                                   
REMARK 500  9 ARG B  69      -78.85   -121.57                                   
REMARK 500  9 PRO B  74        6.36    -64.19                                   
REMARK 500  9 GLU B  78      -93.78    -76.41                                   
REMARK 500  9 ARG B  79      159.74     72.43                                   
REMARK 500  9 VAL B  81      -51.31   -166.26                                   
REMARK 500  9 ASP B  83       78.58     41.42                                   
REMARK 500  9 ASP B  90      170.98    -59.23                                   
REMARK 500  9 SER B  98       64.97   -157.77                                   
REMARK 500  9 VAL B 103      -46.53   -145.35                                   
REMARK 500  9 ASP B 109      -57.03     71.02                                   
REMARK 500  9 HIS B 110       48.31    -82.64                                   
REMARK 500  9 ILE B 112       13.87    -69.73                                   
REMARK 500  9 LYS B 128       41.06    -76.64                                   
REMARK 500  9 ASN B 139       43.79   -160.61                                   
REMARK 500  9 ARG B 143       73.36    -65.58                                   
REMARK 500  9 ALA B 152     -114.71    -91.71                                   
REMARK 500 10 THR A   2      -44.24   -158.45                                   
REMARK 500 10 GLU A  49     -167.75     52.71                                   
REMARK 500 10 ASN A  53        8.86   -151.79                                   
REMARK 500 10 CYS A  57       35.30     70.24                                   
REMARK 500 10 THR A  58      -57.51   -131.80                                   
REMARK 500 10 ALA A  60      -55.31    -23.11                                   
REMARK 500 10 PRO A  62     -155.97   -122.21                                   
REMARK 500 10 HIS A  63       46.85    -77.93                                   
REMARK 500 10 LEU A  67       47.47    -84.23                                   
REMARK 500 10 SER A  68       91.39    -61.29                                   
REMARK 500 10 PRO A  74       18.30    -69.38                                   
REMARK 500 10 GLU A  78       34.88    -96.20                                   
REMARK 500 10 ASP A  90      171.60    -58.92                                   
REMARK 500 10 SER A  98       88.95   -157.97                                   
REMARK 500 10 VAL A 103      -46.24   -142.59                                   
REMARK 500 10 ASP A 109      -59.67     71.53                                   
REMARK 500 10 SER A 111       78.26     26.43                                   
REMARK 500 10 LYS A 136      -73.77   -117.87                                   
REMARK 500 10 ASN A 139       39.55   -170.76                                   
REMARK 500 10 ARG A 143       69.32    -68.18                                   
REMARK 500 10 ILE B  17       56.89   -146.75                                   
REMARK 500 10 ASP B  52      148.63    -39.57                                   
REMARK 500 10 ASN B  53       20.06   -153.88                                   
REMARK 500 10 CYS B  57       51.73     34.10                                   
REMARK 500 10 THR B  58      -46.18   -159.97                                   
REMARK 500 10 ALA B  60      -32.52    -39.02                                   
REMARK 500 10 PRO B  62     -134.05    -73.94                                   
REMARK 500 10 LEU B  67       48.73   -144.48                                   
REMARK 500 10 SER B  68      107.17    -40.61                                   
REMARK 500 10 GLU B  78      -81.32    -78.20                                   
REMARK 500 10 ARG B  79      175.69     59.76                                   
REMARK 500 10 VAL B  81      -55.30   -157.41                                   
REMARK 500 10 SER B  98       68.06   -158.47                                   
REMARK 500 10 SER B 102       60.33   -105.40                                   
REMARK 500 10 VAL B 103      -56.71   -127.92                                   
REMARK 500 10 ASP B 109      -49.97   -160.48                                   
REMARK 500 10 HIS B 110       40.00    -80.46                                   
REMARK 500 10 ILE B 112       45.76    -78.35                                   
REMARK 500 10 LEU B 126       63.29     61.05                                   
REMARK 500 10 ARG B 143       75.52    -64.43                                   
REMARK 500 11 THR A   2      -45.85   -165.11                                   
REMARK 500 11 VAL A  14       63.90    -63.26                                   
REMARK 500 11 GLN A  15       47.75    -95.45                                   
REMARK 500 11 GLU A  40     -176.40    -62.24                                   
REMARK 500 11 ASN A  53       22.39   -156.33                                   
REMARK 500 11 THR A  58      -52.39   -129.44                                   
REMARK 500 11 ALA A  60       46.51    -78.29                                   
REMARK 500 11 PRO A  62       73.79    -68.61                                   
REMARK 500 11 PHE A  64       68.84    -68.96                                   
REMARK 500 11 PRO A  74        7.60    -66.58                                   
REMARK 500 11 ARG A  79      114.65    -26.09                                   
REMARK 500 11 VAL A  81     -103.43   -165.38                                   
REMARK 500 11 SER A  98       68.50   -154.79                                   
REMARK 500 11 SER A 107       46.51   -155.90                                   
REMARK 500 11 ASP A 109      -52.32     73.94                                   
REMARK 500 11 SER A 111       75.48     37.79                                   
REMARK 500 11 ARG A 143       72.95    -61.71                                   
REMARK 500 11 GLU B  24     -139.11   -126.39                                   
REMARK 500 11 GLU B  40      154.38    -48.95                                   
REMARK 500 11 ASP B  52      152.43    -46.38                                   
REMARK 500 11 ASN B  53       24.46   -152.21                                   
REMARK 500 11 HIS B  63      100.33     62.33                                   
REMARK 500 11 PHE B  64      -47.01    -27.38                                   
REMARK 500 11 ASN B  65       76.75     19.39                                   
REMARK 500 11 SER B  68       90.25    -17.30                                   
REMARK 500 11 HIS B  71       94.84      2.16                                   
REMARK 500 11 PRO B  74        7.25    -65.28                                   
REMARK 500 11 GLU B  78       34.13    -87.14                                   
REMARK 500 11 VAL B  81      -19.88    175.46                                   
REMARK 500 11 SER B  98       60.80   -156.53                                   
REMARK 500 11 SER B 111       75.64     37.90                                   
REMARK 500 11 LYS B 128       48.99    -79.01                                   
REMARK 500 11 ARG B 143       73.23    -66.45                                   
REMARK 500 11 ILE B 149      -94.48    -74.75                                   
REMARK 500 12 THR A   2      -36.44   -172.37                                   
REMARK 500 12 VAL A  31       57.91    -98.48                                   
REMARK 500 12 GLU A  49      -72.51    -67.23                                   
REMARK 500 12 ASP A  52      155.34    -45.14                                   
REMARK 500 12 ASN A  53       15.37   -150.17                                   
REMARK 500 12 ALA A  60      -39.25    -30.56                                   
REMARK 500 12 PRO A  62     -164.95    -71.44                                   
REMARK 500 12 LEU A  67       49.18    -78.09                                   
REMARK 500 12 SER A  68      106.55    -57.14                                   
REMARK 500 12 ARG A  69      -88.02   -134.70                                   
REMARK 500 12 PRO A  74       14.72    -67.79                                   
REMARK 500 12 ARG A  79      149.81    -35.52                                   
REMARK 500 12 HIS A  80     -100.42    -70.06                                   
REMARK 500 12 VAL A  81       25.06   -151.64                                   
REMARK 500 12 LEU A  84       33.02    -94.49                                   
REMARK 500 12 SER A  98       57.78   -155.75                                   
REMARK 500 12 VAL A 103      -41.06   -136.23                                   
REMARK 500 12 ASP A 109      -56.67     71.61                                   
REMARK 500 12 SER A 111       96.41    -17.76                                   
REMARK 500 12 LEU A 126       52.79     39.32                                   
REMARK 500 12 LYS A 128       24.37    -78.97                                   
REMARK 500 12 LYS A 136      -75.62   -118.91                                   
REMARK 500 12 ASN A 139       28.02     90.74                                   
REMARK 500 12 ARG A 143       63.29    -63.71                                   
REMARK 500 12 THR B   2      -47.20   -170.13                                   
REMARK 500 12 THR B  58      -58.19   -155.14                                   
REMARK 500 12 ALA B  60      -34.56    -33.02                                   
REMARK 500 12 HIS B  63      -44.30     75.20                                   
REMARK 500 12 LEU B  67       88.13    -68.96                                   
REMARK 500 12 SER B  68       82.13    -57.70                                   
REMARK 500 12 HIS B  71       98.23    -12.09                                   
REMARK 500 12 PRO B  74        1.45    -67.22                                   
REMARK 500 12 GLU B  78       43.52    -95.14                                   
REMARK 500 12 VAL B  81      -38.85   -173.74                                   
REMARK 500 12 SER B  98       66.56   -158.13                                   
REMARK 500 12 ASP B 109      -51.13   -120.22                                   
REMARK 500 12 SER B 111       72.21     33.43                                   
REMARK 500 12 LYS B 128       42.57    -80.53                                   
REMARK 500 12 ASN B 139       34.17   -161.15                                   
REMARK 500 12 ARG B 143       72.78    -60.20                                   
REMARK 500 12 ALA B 152      -48.15   -130.21                                   
REMARK 500 13 ILE A  17       56.44   -153.22                                   
REMARK 500 13 LYS A  30       93.87    -68.48                                   
REMARK 500 13 HIS A  48      157.56     61.29                                   
REMARK 500 13 ASN A  53       28.78   -151.17                                   
REMARK 500 13 CYS A  57       58.18     33.56                                   
REMARK 500 13 THR A  58      -56.34   -136.06                                   
REMARK 500 13 HIS A  63       77.13     65.34                                   
REMARK 500 13 PHE A  64      -60.72    -18.42                                   
REMARK 500 13 ASN A  65       86.55      4.49                                   
REMARK 500 13 SER A  68      102.00    -31.86                                   
REMARK 500 13 HIS A  71      104.04    -29.55                                   
REMARK 500 13 PRO A  74        7.49    -67.20                                   
REMARK 500 13 ARG A  79      138.10    -36.81                                   
REMARK 500 13 VAL A  81       64.33     10.46                                   
REMARK 500 13 SER A  98       64.09   -155.97                                   
REMARK 500 13 VAL A 103      -43.09   -135.74                                   
REMARK 500 13 LEU A 106      -38.02    -37.79                                   
REMARK 500 13 SER A 107       56.31   -144.83                                   
REMARK 500 13 ASP A 109      -53.38   -167.67                                   
REMARK 500 13 SER A 111      173.64     53.77                                   
REMARK 500 13 LYS A 136      -76.80   -114.15                                   
REMARK 500 13 ASN A 139       21.25     49.57                                   
REMARK 500 13 GLU B  24     -145.06   -137.26                                   
REMARK 500 13 ASN B  53       30.08   -153.71                                   
REMARK 500 13 THR B  58      -39.35   -161.24                                   
REMARK 500 13 ALA B  60      -36.26    -34.27                                   
REMARK 500 13 PHE B  64       74.65    -69.70                                   
REMARK 500 13 SER B  68      108.73    -42.48                                   
REMARK 500 13 PRO B  74        5.02    -66.02                                   
REMARK 500 13 ARG B  79      130.73    -28.10                                   
REMARK 500 13 VAL B  81      -50.66   -168.18                                   
REMARK 500 13 SER B  98       68.29   -157.91                                   
REMARK 500 13 VAL B 103      -45.04   -132.43                                   
REMARK 500 13 ASP B 109      -52.22   -158.27                                   
REMARK 500 13 SER B 111       76.28     25.20                                   
REMARK 500 13 LYS B 128       37.34    -79.90                                   
REMARK 500 13 ASN B 139       31.76     71.12                                   
REMARK 500 13 ARG B 143       73.73    -64.62                                   
REMARK 500 14 THR A   2      -43.73   -155.99                                   
REMARK 500 14 HIS A  48      175.76     57.29                                   
REMARK 500 14 CYS A  57       80.42     15.75                                   
REMARK 500 14 THR A  58      -54.99   -161.38                                   
REMARK 500 14 ALA A  60       -6.76    -44.97                                   
REMARK 500 14 HIS A  63       38.28     72.12                                   
REMARK 500 14 SER A  68       98.37    -45.95                                   
REMARK 500 14 HIS A  71      112.53    -35.20                                   
REMARK 500 14 VAL A  81      -91.41   -169.33                                   
REMARK 500 14 SER A  98       86.81   -157.36                                   
REMARK 500 14 SER A 102       49.42    -87.15                                   
REMARK 500 14 VAL A 103      -51.10   -145.24                                   
REMARK 500 14 ASP A 109      -60.25     72.41                                   
REMARK 500 14 SER A 111       82.05     54.96                                   
REMARK 500 14 ASN A 139       42.60   -157.30                                   
REMARK 500 14 ARG A 143       92.03    -59.03                                   
REMARK 500 14 ILE B  17       81.50   -153.31                                   
REMARK 500 14 HIS B  48      171.70     58.15                                   
REMARK 500 14 ASN B  53       33.02   -151.81                                   
REMARK 500 14 CYS B  57        7.72    -65.27                                   
REMARK 500 14 ALA B  60      -39.92    -27.89                                   
REMARK 500 14 PRO B  62       37.94    -86.70                                   
REMARK 500 14 HIS B  63      116.38     71.31                                   
REMARK 500 14 PHE B  64       94.06    -33.80                                   
REMARK 500 14 LEU B  67       41.88    -79.03                                   
REMARK 500 14 SER B  68       69.91     17.41                                   
REMARK 500 14 HIS B  71       87.46     -2.33                                   
REMARK 500 14 VAL B  81      -46.73   -169.23                                   
REMARK 500 14 SER B  98       57.61   -157.63                                   
REMARK 500 14 VAL B 103      -55.86   -120.74                                   
REMARK 500 14 ASP B 109      -49.61   -136.66                                   
REMARK 500 14 SER B 111       67.13     31.95                                   
REMARK 500 14 LYS B 128       47.19    -79.13                                   
REMARK 500 14 LYS B 136      -65.96   -109.32                                   
REMARK 500 14 ASN B 139       39.73   -164.43                                   
REMARK 500 14 ARG B 143       76.61    -64.21                                   
REMARK 500 14 ILE B 149      -88.17    -67.49                                   
REMARK 500 14 ALA B 152      -50.53   -124.21                                   
REMARK 500 15 HIS A  48      176.08     63.03                                   
REMARK 500 15 GLU A  49      -64.83    -92.47                                   
REMARK 500 15 ASN A  53       21.55   -162.56                                   
REMARK 500 15 CYS A  57       59.91     34.75                                   
REMARK 500 15 THR A  58      -54.24   -153.77                                   
REMARK 500 15 ALA A  60      -38.51    -29.67                                   
REMARK 500 15 PHE A  64       26.64    -73.19                                   
REMARK 500 15 ASN A  65      150.72    -46.22                                   
REMARK 500 15 ARG A  69      -81.13   -135.68                                   
REMARK 500 15 HIS A  80       48.86    -77.46                                   
REMARK 500 15 VAL A  81       49.38     33.66                                   
REMARK 500 15 SER A  98       70.35   -156.39                                   
REMARK 500 15 ASP A 109      -53.16   -155.82                                   
REMARK 500 15 SER A 111       91.60     47.57                                   
REMARK 500 15 LYS A 136      -84.86   -106.75                                   
REMARK 500 15 THR B   2      -49.46   -141.00                                   
REMARK 500 15 GLU B  49      -87.54     24.43                                   
REMARK 500 15 ASP B  52      150.74    -39.48                                   
REMARK 500 15 ASN B  53       21.17   -157.17                                   
REMARK 500 15 THR B  58      -55.86   -154.51                                   
REMARK 500 15 ALA B  60      -51.47    -24.84                                   
REMARK 500 15 PRO B  62     -164.68    -71.71                                   
REMARK 500 15 PHE B  64       88.22    -69.91                                   
REMARK 500 15 SER B  68      101.77    -38.28                                   
REMARK 500 15 HIS B  71      113.26    -36.87                                   
REMARK 500 15 PRO B  74        6.64    -64.27                                   
REMARK 500 15 ARG B  79      120.75    -35.23                                   
REMARK 500 15 VAL B  81      -47.78   -178.03                                   
REMARK 500 15 ASP B  90      171.20    -57.51                                   
REMARK 500 15 SER B  98       59.85   -152.72                                   
REMARK 500 15 SER B 107     -159.00    -73.83                                   
REMARK 500 15 SER B 111      109.43      3.39                                   
REMARK 500 15 LYS B 128       42.63    -83.49                                   
REMARK 500 15 ASN B 139       21.53   -171.81                                   
REMARK 500 15 ARG B 143       73.84    -60.84                                   
REMARK 500 16 THR A   2      -43.77   -162.34                                   
REMARK 500 16 GLU A  40      125.47    -39.59                                   
REMARK 500 16 ASP A  52       98.45    -67.56                                   
REMARK 500 16 CYS A  57       43.17     37.39                                   
REMARK 500 16 THR A  58      -57.74   -133.14                                   
REMARK 500 16 SER A  68       81.93     20.75                                   
REMARK 500 16 ARG A  69      -84.73   -111.32                                   
REMARK 500 16 PRO A  74       19.22    -68.11                                   
REMARK 500 16 ARG A  79      153.13    -43.86                                   
REMARK 500 16 SER A  98       72.06   -158.18                                   
REMARK 500 16 SER A 102       53.25    -98.40                                   
REMARK 500 16 VAL A 103      -45.25   -157.24                                   
REMARK 500 16 SER A 107       67.25   -156.73                                   
REMARK 500 16 ASP A 109      -57.89     69.75                                   
REMARK 500 16 HIS A 110       33.23    -82.48                                   
REMARK 500 16 SER A 111      104.10    -52.43                                   
REMARK 500 16 LYS A 136      -81.64   -113.18                                   
REMARK 500 16 ASN A 139       40.17   -173.77                                   
REMARK 500 16 ARG A 143       64.22    -67.07                                   
REMARK 500 16 GLU B  24     -156.98   -125.62                                   
REMARK 500 16 ASP B  52      151.21    -42.86                                   
REMARK 500 16 ASN B  53       21.68   -162.46                                   
REMARK 500 16 CYS B  57       69.96    -66.53                                   
REMARK 500 16 THR B  58      -53.04   -153.53                                   
REMARK 500 16 ALA B  60       47.30    -75.31                                   
REMARK 500 16 HIS B  63       35.16     86.77                                   
REMARK 500 16 PHE B  64       70.34    -68.24                                   
REMARK 500 16 SER B  68      102.02    -45.06                                   
REMARK 500 16 LYS B  70       56.98   -111.94                                   
REMARK 500 16 HIS B  71       85.81     44.98                                   
REMARK 500 16 PRO B  74        8.44    -62.42                                   
REMARK 500 16 GLU B  78       26.07    -76.58                                   
REMARK 500 16 VAL B  81      -58.63   -163.82                                   
REMARK 500 16 SER B  98       57.84   -158.01                                   
REMARK 500 16 VAL B 103      -44.50   -155.01                                   
REMARK 500 16 SER B 111       69.13     37.18                                   
REMARK 500 16 ILE B 113      -36.69    -31.12                                   
REMARK 500 16 LYS B 128       35.22    -83.31                                   
REMARK 500 16 LYS B 136      -69.74   -142.19                                   
REMARK 500 16 ASN B 139       38.63   -170.09                                   
REMARK 500 16 ARG B 143       75.22    -66.68                                   
REMARK 500 17 THR A   2      -53.61   -122.31                                   
REMARK 500 17 ASN A  53       28.98   -158.00                                   
REMARK 500 17 CYS A  57       72.33    -68.23                                   
REMARK 500 17 THR A  58      -47.92   -158.56                                   
REMARK 500 17 ALA A  60      -28.86    -33.09                                   
REMARK 500 17 PRO A  62     -141.22    -72.81                                   
REMARK 500 17 SER A  68      108.95    -42.23                                   
REMARK 500 17 HIS A  71      102.48    -25.52                                   
REMARK 500 17 VAL A  81       41.19    -74.49                                   
REMARK 500 17 ASP A  90      170.63    -59.33                                   
REMARK 500 17 SER A  98       73.88   -155.13                                   
REMARK 500 17 VAL A 103      -54.26   -126.38                                   
REMARK 500 17 SER A 111       76.14     46.97                                   
REMARK 500 17 ASN A 139       44.05   -157.95                                   
REMARK 500 17 ARG A 143       73.30    -64.55                                   
REMARK 500 17 GLU B  24     -116.06   -127.42                                   
REMARK 500 17 ASP B  52      109.12    -34.37                                   
REMARK 500 17 CYS B  57       37.50     30.55                                   
REMARK 500 17 PRO B  62     -170.92    -69.31                                   
REMARK 500 17 PRO B  74        2.37    -64.88                                   
REMARK 500 17 VAL B  81      -99.61    179.78                                   
REMARK 500 17 LEU B  84       38.84    -89.44                                   
REMARK 500 17 SER B  98       55.88   -157.77                                   
REMARK 500 17 VAL B 103      -46.79   -142.98                                   
REMARK 500 17 ASP B 109      -52.29   -131.79                                   
REMARK 500 17 HIS B 110       37.13    -81.85                                   
REMARK 500 17 ILE B 112       34.79    -75.41                                   
REMARK 500 17 ASN B 139       30.55   -168.79                                   
REMARK 500 17 ARG B 143       68.25    -69.23                                   
REMARK 500 18 THR A   2      -49.31   -154.77                                   
REMARK 500 18 VAL A  14       93.75    -67.22                                   
REMARK 500 18 ILE A  17       58.66   -143.77                                   
REMARK 500 18 GLU A  40      156.27    -48.93                                   
REMARK 500 18 ASP A  52       99.84    -59.07                                   
REMARK 500 18 CYS A  57       62.04   -155.17                                   
REMARK 500 18 THR A  58      -49.92   -162.50                                   
REMARK 500 18 ALA A  60      -27.36    -39.82                                   
REMARK 500 18 ARG A  69      -85.71   -136.93                                   
REMARK 500 18 PRO A  74        3.71    -64.92                                   
REMARK 500 18 VAL A  81      -98.43   -173.50                                   
REMARK 500 18 SER A  98       65.34   -156.11                                   
REMARK 500 18 VAL A 103      -53.53   -156.02                                   
REMARK 500 18 ASP A 109      -54.29   -147.22                                   
REMARK 500 18 ILE A 112       31.77    -74.53                                   
REMARK 500 18 ASN A 139       40.42   -163.88                                   
REMARK 500 18 ARG A 143       73.47    -64.95                                   
REMARK 500 18 ASN B  53       16.54   -158.24                                   
REMARK 500 18 THR B  58      -50.22   -120.83                                   
REMARK 500 18 ALA B  60       32.09    -72.49                                   
REMARK 500 18 SER B  68      104.95    -34.15                                   
REMARK 500 18 PRO B  74        1.66    -65.48                                   
REMARK 500 18 GLU B  78       63.53   -110.55                                   
REMARK 500 18 HIS B  80      -71.54    -66.49                                   
REMARK 500 18 VAL B  81      -53.89   -166.79                                   
REMARK 500 18 SER B  98       83.02   -158.42                                   
REMARK 500 18 ASP B 109      -50.89   -128.08                                   
REMARK 500 18 LYS B 136      -61.04   -128.69                                   
REMARK 500 18 ASN B 139       39.41   -162.86                                   
REMARK 500 18 ARG B 143       75.79    -65.70                                   
REMARK 500 19 THR A   2      -38.01   -167.51                                   
REMARK 500 19 ILE A  17       56.94   -151.54                                   
REMARK 500 19 GLN A  22       16.21   -148.24                                   
REMARK 500 19 LYS A  23      -57.38     74.23                                   
REMARK 500 19 GLU A  24     -157.26   -127.68                                   
REMARK 500 19 VAL A  31       59.35   -102.76                                   
REMARK 500 19 ALA A  60       -6.28    -50.06                                   
REMARK 500 19 SER A  68      104.85    -40.75                                   
REMARK 500 19 HIS A  71      101.55    -30.18                                   
REMARK 500 19 VAL A  81      -45.97   -173.90                                   
REMARK 500 19 SER A  98       57.63   -157.52                                   
REMARK 500 19 ASP A 109      -51.44   -167.71                                   
REMARK 500 19 SER A 111       70.66     38.98                                   
REMARK 500 19 ASN A 131      178.85    174.61                                   
REMARK 500 19 LYS A 136      -73.65   -118.82                                   
REMARK 500 19 ASN A 139       39.12   -173.38                                   
REMARK 500 19 ARG A 143       72.89    -64.70                                   
REMARK 500 19 LYS B  23       34.95   -143.23                                   
REMARK 500 19 VAL B  31       58.77   -102.42                                   
REMARK 500 19 GLU B  49      -94.42     47.65                                   
REMARK 500 19 ASP B  52      135.07    -37.71                                   
REMARK 500 19 ASN B  53       23.99   -146.05                                   
REMARK 500 19 CYS B  57       57.65     17.43                                   
REMARK 500 19 THR B  58      -61.90   -130.48                                   
REMARK 500 19 PRO B  62     -137.35    -78.67                                   
REMARK 500 19 HIS B  63       50.68   -100.99                                   
REMARK 500 19 ARG B  69      -86.49   -131.33                                   
REMARK 500 19 PRO B  74        4.61    -65.74                                   
REMARK 500 19 GLU B  78       61.50   -119.65                                   
REMARK 500 19 HIS B  80      -84.57    -65.99                                   
REMARK 500 19 VAL B  81      -82.06   -149.82                                   
REMARK 500 19 SER B  98       59.14   -156.98                                   
REMARK 500 19 SER B 102       38.11    -90.25                                   
REMARK 500 19 ASP B 109      -51.87   -163.04                                   
REMARK 500 19 SER B 111       75.36     47.76                                   
REMARK 500 19 ILE B 112       65.19    -68.97                                   
REMARK 500 19 ASP B 125       28.31    -79.20                                   
REMARK 500 19 LEU B 126       60.23     23.86                                   
REMARK 500 19 LYS B 128       44.15    -84.46                                   
REMARK 500 19 ILE B 149      -91.67    -67.41                                   
REMARK 500 20 PHE A  64       43.77    -71.85                                   
REMARK 500 20 SER A  68      109.75    -35.47                                   
REMARK 500 20 PRO A  74        3.68    -63.99                                   
REMARK 500 20 GLU A  78       49.89   -103.48                                   
REMARK 500 20 VAL A  81      -69.00   -161.85                                   
REMARK 500 20 SER A  98       64.02   -158.30                                   
REMARK 500 20 SER A 107     -119.27    -84.12                                   
REMARK 500 20 SER A 111       76.38     39.01                                   
REMARK 500 20 ILE A 113      132.59    -38.67                                   
REMARK 500 20 LYS A 136      -79.41   -111.61                                   
REMARK 500 20 ARG A 143       68.16    -64.13                                   
REMARK 500 20 ALA A 152      -36.11   -132.36                                   
REMARK 500 20 THR B   2      -29.68     70.62                                   
REMARK 500 20 GLU B  49      -80.80     35.04                                   
REMARK 500 20 ASN B  53       27.86   -154.63                                   
REMARK 500 20 CYS B  57       46.28     38.06                                   
REMARK 500 20 THR B  58      -54.15   -153.31                                   
REMARK 500 20 ALA B  60      -50.68    -24.97                                   
REMARK 500 20 PRO B  62     -163.38    -74.76                                   
REMARK 500 20 HIS B  63       48.66    -81.03                                   
REMARK 500 20 PRO B  66       49.68    -76.46                                   
REMARK 500 20 LEU B  67       55.78   -178.35                                   
REMARK 500 20 SER B  68      110.23    -37.11                                   
REMARK 500 20 PRO B  74       10.47    -69.16                                   
REMARK 500 20 GLU B  78       42.87    -82.14                                   
REMARK 500 20 HIS B  80      -79.91    -68.97                                   
REMARK 500 20 VAL B  81      -79.28   -149.18                                   
REMARK 500 20 VAL B 103      -45.45   -133.33                                   
REMARK 500 20 ASP B 109      -51.56   -165.29                                   
REMARK 500 20 SER B 111       70.07     42.51                                   
REMARK 500 20 LYS B 128       49.88    -79.29                                   
REMARK 500 20 ILE B 149      -81.41    -61.86                                   
REMARK 500 20 ALA B 152      -70.08    -79.98                                   
REMARK 500 21 VAL A  14       97.56    -65.62                                   
REMARK 500 21 ILE A  17       59.60   -155.22                                   
REMARK 500 21 THR A  58      -66.95   -127.21                                   
REMARK 500 21 HIS A  63       49.74     71.70                                   
REMARK 500 21 PHE A  64       38.12    -72.21                                   
REMARK 500 21 ASN A  65      151.15    -44.27                                   
REMARK 500 21 SER A  68      109.20    -55.50                                   
REMARK 500 21 ARG A  69      -97.15   -121.29                                   
REMARK 500 21 PRO A  74       14.93    -68.27                                   
REMARK 500 21 VAL A  81       48.66     31.78                                   
REMARK 500 21 SER A  98       70.42   -157.45                                   
REMARK 500 21 VAL A 103      -46.13   -155.80                                   
REMARK 500 21 ASP A 109      -53.47   -136.23                                   
REMARK 500 21 LEU A 126       51.35     38.94                                   
REMARK 500 21 LYS A 136      -82.10   -113.91                                   
REMARK 500 21 ARG A 143       76.55    -57.41                                   
REMARK 500 21 ILE A 149      -96.09    -75.07                                   
REMARK 500 21 ALA A 152     -102.11   -112.11                                   
REMARK 500 21 THR B   2      -47.33   -160.49                                   
REMARK 500 21 VAL B  14      107.54    -58.65                                   
REMARK 500 21 ILE B  17       87.22   -154.26                                   
REMARK 500 21 ASP B  52      146.34    -35.93                                   
REMARK 500 21 ASN B  53       28.44   -144.36                                   
REMARK 500 21 CYS B  57       49.62     11.50                                   
REMARK 500 21 THR B  58      -53.68   -120.84                                   
REMARK 500 21 PRO B  62     -172.73    -68.50                                   
REMARK 500 21 HIS B  63       45.09    -78.81                                   
REMARK 500 21 ARG B  69      -88.89   -124.58                                   
REMARK 500 21 PRO B  74       12.94    -68.05                                   
REMARK 500 21 ARG B  79      153.58    -44.25                                   
REMARK 500 21 VAL B  81      -75.38    173.31                                   
REMARK 500 21 SER B  98       62.80   -156.73                                   
REMARK 500 21 ASP B 109      -57.84   -152.03                                   
REMARK 500 21 SER B 111      -51.21     70.77                                   
REMARK 500 21 ASP B 125       24.51    -78.45                                   
REMARK 500 21 LEU B 126       51.60     36.64                                   
REMARK 500 21 ARG B 143       84.92    -64.90                                   
REMARK 500 22 ILE A  17       82.35   -156.37                                   
REMARK 500 22 THR A  58      -52.50   -134.59                                   
REMARK 500 22 ALA A  60        3.52    -66.12                                   
REMARK 500 22 SER A  68       94.85    -42.06                                   
REMARK 500 22 HIS A  71      105.43    -19.22                                   
REMARK 500 22 GLU A  78       32.93    -84.98                                   
REMARK 500 22 HIS A  80      -70.75    -66.56                                   
REMARK 500 22 VAL A  81     -105.06   -147.19                                   
REMARK 500 22 ASP A  90      170.86    -57.33                                   
REMARK 500 22 SER A  98       69.77   -158.10                                   
REMARK 500 22 ASP A 109      -50.06   -164.51                                   
REMARK 500 22 ILE A 112       21.48    -74.14                                   
REMARK 500 22 LYS A 128       31.12    -94.56                                   
REMARK 500 22 ASN A 139       37.88   -168.09                                   
REMARK 500 22 ARG A 143       80.47    -63.06                                   
REMARK 500 22 THR B   2      -49.22   -156.83                                   
REMARK 500 22 VAL B  14       94.50    -67.97                                   
REMARK 500 22 GLU B  24     -169.87   -120.80                                   
REMARK 500 22 GLU B  40      153.00    -49.20                                   
REMARK 500 22 ARG B  69      -97.83   -137.33                                   
REMARK 500 22 PRO B  74        4.45    -65.41                                   
REMARK 500 22 VAL B  81      -93.77   -169.34                                   
REMARK 500 22 SER B  98       83.81   -157.24                                   
REMARK 500 22 SER B 102       61.73   -100.77                                   
REMARK 500 22 VAL B 103      -47.07   -155.39                                   
REMARK 500 22 SER B 111       92.84     21.35                                   
REMARK 500 22 LYS B 128       48.75    -79.80                                   
REMARK 500 23 VAL A  14       96.81    -64.54                                   
REMARK 500 23 LEU A  38     -179.49    -68.20                                   
REMARK 500 23 CYS A  57       24.01     49.33                                   
REMARK 500 23 ALA A  60      -38.27    -30.43                                   
REMARK 500 23 HIS A  63      -64.80     71.56                                   
REMARK 500 23 PHE A  64       49.32     26.02                                   
REMARK 500 23 ARG A  69      -87.64   -129.93                                   
REMARK 500 23 PRO A  74        7.78    -67.13                                   
REMARK 500 23 ARG A  79      161.54    -47.62                                   
REMARK 500 23 HIS A  80       46.85    -78.69                                   
REMARK 500 23 VAL A  81       35.94     33.16                                   
REMARK 500 23 SER A  98       80.88   -158.52                                   
REMARK 500 23 VAL A 103      -39.42   -157.79                                   
REMARK 500 23 ASP A 109      -51.10   -122.31                                   
REMARK 500 23 ASN A 139       39.14   -168.81                                   
REMARK 500 23 ARG A 143       72.82    -65.36                                   
REMARK 500 23 VAL B  14       91.16    -60.70                                   
REMARK 500 23 ILE B  17       84.11   -151.42                                   
REMARK 500 23 ASP B  52      125.35    -32.16                                   
REMARK 500 23 CYS B  57       18.65   -157.00                                   
REMARK 500 23 ALA B  60      -29.64    -38.14                                   
REMARK 500 23 SER B  68      108.67    -37.03                                   
REMARK 500 23 GLU B  78       51.36   -114.50                                   
REMARK 500 23 VAL B  81      -47.58   -171.65                                   
REMARK 500 23 SER B  98       72.43   -158.26                                   
REMARK 500 23 SER B 102       51.48   -103.50                                   
REMARK 500 23 VAL B 103      -47.91   -156.32                                   
REMARK 500 23 SER B 107       83.50   -156.50                                   
REMARK 500 23 ASP B 109      -52.88   -153.95                                   
REMARK 500 23 LYS B 128       21.63    -73.43                                   
REMARK 500 23 LYS B 136      -92.34   -100.61                                   
REMARK 500 23 ARG B 143       86.99    -67.23                                   
REMARK 500 24 THR A   2      -48.44   -151.55                                   
REMARK 500 24 VAL A  14       87.18    -58.49                                   
REMARK 500 24 ASN A  53       25.65   -161.10                                   
REMARK 500 24 THR A  58      -49.62   -155.76                                   
REMARK 500 24 ASN A  65      172.23     34.27                                   
REMARK 500 24 PRO A  74       14.68    -69.27                                   
REMARK 500 24 ARG A  79     -141.40     41.52                                   
REMARK 500 24 VAL A  81       38.96     37.80                                   
REMARK 500 24 SER A  98       57.82   -158.35                                   
REMARK 500 24 VAL A 103      -43.46   -145.19                                   
REMARK 500 24 ASP A 109      -51.35   -163.06                                   
REMARK 500 24 SER A 111       74.25     41.11                                   
REMARK 500 24 LYS A 136      -85.44   -112.83                                   
REMARK 500 24 ASN A 139       29.62     46.80                                   
REMARK 500 24 ARG A 143       73.03    -66.43                                   
REMARK 500 24 THR B   2      -45.32   -165.21                                   
REMARK 500 24 GLN B  22       65.49   -154.20                                   
REMARK 500 24 ASN B  53       22.50   -165.11                                   
REMARK 500 24 THR B  58      -55.12   -138.18                                   
REMARK 500 24 SER B  68      106.16    -35.96                                   
REMARK 500 24 PRO B  74        2.03    -66.60                                   
REMARK 500 24 HIS B  80      -70.61    -64.68                                   
REMARK 500 24 VAL B  81      -63.81   -165.83                                   
REMARK 500 24 SER B  98       51.48   -157.49                                   
REMARK 500 24 SER B 102       63.34   -108.71                                   
REMARK 500 24 VAL B 103      -47.61   -151.97                                   
REMARK 500 24 ASP B 109      -53.57   -156.37                                   
REMARK 500 24 ILE B 113      -55.63    -27.13                                   
REMARK 500 24 LYS B 128       44.74    -81.38                                   
REMARK 500 24 ARG B 143       68.62    -58.74                                   
REMARK 500 24 ALA B 152     -114.21   -102.57                                   
REMARK 500 25 THR A   2      -63.89    -96.21                                   
REMARK 500 25 PRO A  13       37.45    -75.82                                   
REMARK 500 25 CYS A  57       48.87     38.78                                   
REMARK 500 25 THR A  58      -53.50   -127.76                                   
REMARK 500 25 HIS A  63      -34.16     71.81                                   
REMARK 500 25 PHE A  64       25.90     43.42                                   
REMARK 500 25 LEU A  67        2.80    -63.05                                   
REMARK 500 25 SER A  68       54.22     26.84                                   
REMARK 500 25 HIS A  71       97.16     -5.88                                   
REMARK 500 25 VAL A  81      -43.03   -170.97                                   
REMARK 500 25 SER A  98       60.69   -157.63                                   
REMARK 500 25 SER A 107     -157.04    -88.38                                   
REMARK 500 25 SER A 111       78.63     13.32                                   
REMARK 500 25 ARG A 143       71.39    -66.25                                   
REMARK 500 25 THR B   2      -60.48   -150.76                                   
REMARK 500 25 ALA B   6       97.28   -162.27                                   
REMARK 500 25 ASN B  26       28.15   -149.18                                   
REMARK 500 25 THR B  58      -57.43   -127.75                                   
REMARK 500 25 SER B  68       97.31    -14.96                                   
REMARK 500 25 HIS B  71       96.51     -9.99                                   
REMARK 500 25 PRO B  74        5.97    -66.59                                   
REMARK 500 25 VAL B  81     -105.69   -172.37                                   
REMARK 500 25 ASP B  90      170.98    -59.53                                   
REMARK 500 25 SER B  98       57.69   -157.76                                   
REMARK 500 25 ASP B 109      -48.81   -161.21                                   
REMARK 500 25 SER B 111       69.83     23.86                                   
REMARK 500 25 LYS B 128       40.84    -80.42                                   
REMARK 500 25 LYS B 136      -62.52   -122.22                                   
REMARK 500 25 ARG B 143       72.68    -64.37                                   
REMARK 500 25 ILE B 149      -83.93    -59.32                                   
REMARK 500 26 THR A   2      -43.43   -171.41                                   
REMARK 500 26 ASN A  19       59.79   -143.58                                   
REMARK 500 26 ASN A  53       29.43   -148.38                                   
REMARK 500 26 CYS A  57       53.63     39.35                                   
REMARK 500 26 THR A  58      -54.85   -156.17                                   
REMARK 500 26 ALA A  60      -30.31    -33.77                                   
REMARK 500 26 PHE A  64       74.39    -68.00                                   
REMARK 500 26 SER A  68       90.34    -41.13                                   
REMARK 500 26 ARG A  69     -164.00   -116.19                                   
REMARK 500 26 HIS A  71      100.49    -16.27                                   
REMARK 500 26 PRO A  74       12.85    -67.64                                   
REMARK 500 26 GLU A  78       40.95   -107.36                                   
REMARK 500 26 VAL A  81      -55.75   -168.42                                   
REMARK 500 26 ASP A  96       78.20   -101.59                                   
REMARK 500 26 SER A  98       55.63    -90.77                                   
REMARK 500 26 VAL A 103      -41.28   -148.66                                   
REMARK 500 26 ILE A 104       89.28    -67.13                                   
REMARK 500 26 ASP A 109      -52.23   -125.03                                   
REMARK 500 26 LYS A 128       42.34    -84.23                                   
REMARK 500 26 LYS A 136      -54.67   -120.36                                   
REMARK 500 26 ARG A 143       71.25    -56.24                                   
REMARK 500 26 HIS B  48      171.82     58.03                                   
REMARK 500 26 ASN B  53       21.68   -163.14                                   
REMARK 500 26 CYS B  57       47.53     37.60                                   
REMARK 500 26 THR B  58      -54.89   -121.85                                   
REMARK 500 26 ALA B  60       49.97    -75.02                                   
REMARK 500 26 PRO B  62       47.39    -77.46                                   
REMARK 500 26 LEU B  67       48.90    -78.89                                   
REMARK 500 26 SER B  68      102.93    -14.94                                   
REMARK 500 26 HIS B  71      107.51    -22.66                                   
REMARK 500 26 VAL B  81      -68.66   -170.37                                   
REMARK 500 26 ASP B  90      171.51    -57.56                                   
REMARK 500 26 SER B  98       57.44   -158.44                                   
REMARK 500 26 VAL B 103      -47.77   -150.84                                   
REMARK 500 26 ASP B 109      -50.38   -166.40                                   
REMARK 500 26 SER B 111       73.61     31.43                                   
REMARK 500 26 ILE B 112       20.17    -67.95                                   
REMARK 500 26 LYS B 128       41.44    -79.26                                   
REMARK 500 26 ASN B 139       39.38   -152.52                                   
REMARK 500 27 ILE A  17       81.80   -150.81                                   
REMARK 500 27 ASP A  52      107.13    -48.20                                   
REMARK 500 27 THR A  58      -54.24   -130.18                                   
REMARK 500 27 HIS A  63      -62.27     71.77                                   
REMARK 500 27 PHE A  64       36.72     34.28                                   
REMARK 500 27 ASN A  65      152.24    -45.29                                   
REMARK 500 27 LEU A  67       83.44    -68.82                                   
REMARK 500 27 SER A  68       64.65    -69.54                                   
REMARK 500 27 HIS A  71       87.30     11.14                                   
REMARK 500 27 VAL A  81      -30.29   -166.94                                   
REMARK 500 27 SER A  98       71.75   -157.77                                   
REMARK 500 27 VAL A 103      -49.37   -155.34                                   
REMARK 500 27 ASP A 109      -53.37   -156.45                                   
REMARK 500 27 HIS A 110       48.25    -83.70                                   
REMARK 500 27 ILE A 112       39.84    -72.20                                   
REMARK 500 27 LEU A 126       81.49    -11.86                                   
REMARK 500 27 LYS A 136      -81.19   -123.97                                   
REMARK 500 27 ASN A 139       33.24   -165.64                                   
REMARK 500 27 ARG A 143       73.68    -56.65                                   
REMARK 500 27 ILE A 149      -85.09    -69.17                                   
REMARK 500 27 GLU B  24     -130.42   -122.67                                   
REMARK 500 27 GLU B  40      159.59    -49.44                                   
REMARK 500 27 HIS B  48      148.12     62.16                                   
REMARK 500 27 ASN B  53       18.83   -150.18                                   
REMARK 500 27 THR B  58      -49.70   -133.33                                   
REMARK 500 27 ALA B  60       47.79    -75.96                                   
REMARK 500 27 PRO B  62       72.70    -68.15                                   
REMARK 500 27 PHE B  64       64.69    -69.33                                   
REMARK 500 27 LEU B  67       49.58    -78.68                                   
REMARK 500 27 ARG B  69      -75.22   -140.81                                   
REMARK 500 27 PRO B  74        1.36    -66.51                                   
REMARK 500 27 GLU B  78       58.10    -97.15                                   
REMARK 500 27 VAL B  81      -90.46   -161.67                                   
REMARK 500 27 SER B  98       55.40   -158.78                                   
REMARK 500 27 ASP B 109      -49.82   -166.56                                   
REMARK 500 27 ILE B 112       37.77    -69.77                                   
REMARK 500 27 LYS B 128       42.16    -79.47                                   
REMARK 500 27 ARG B 143       71.65    -65.77                                   
REMARK 500 28 GLU A  49      -87.22     51.71                                   
REMARK 500 28 ASN A  53       28.90   -152.18                                   
REMARK 500 28 THR A  58      -56.98   -158.11                                   
REMARK 500 28 PRO A  62     -162.30    -74.02                                   
REMARK 500 28 HIS A  63       48.99    -80.17                                   
REMARK 500 28 SER A  68      107.66    -55.66                                   
REMARK 500 28 ARG A  69      -91.11   -119.45                                   
REMARK 500 28 PRO A  74       25.50    -69.36                                   
REMARK 500 28 ARG A  79      158.53    -42.29                                   
REMARK 500 28 HIS A  80     -103.81    -69.65                                   
REMARK 500 28 VAL A  81      -90.96   -126.70                                   
REMARK 500 28 SER A  98       76.93   -158.69                                   
REMARK 500 28 VAL A 103      -46.02   -142.69                                   
REMARK 500 28 ASP A 109      -51.64   -134.39                                   
REMARK 500 28 HIS A 110       38.42    -81.70                                   
REMARK 500 28 LYS A 128       37.79    -79.57                                   
REMARK 500 28 LYS A 136      -71.07   -112.21                                   
REMARK 500 28 ARG A 143       72.87     42.66                                   
REMARK 500 28 VAL B  14       92.53    -67.62                                   
REMARK 500 28 LYS B  23       30.74   -149.51                                   
REMARK 500 28 GLU B  49      -86.59     -6.73                                   
REMARK 500 28 CYS B  57       55.51     18.73                                   
REMARK 500 28 ALA B  60       41.51    -74.38                                   
REMARK 500 28 HIS B  63      -72.05     66.17                                   
REMARK 500 28 PHE B  64       56.95      0.72                                   
REMARK 500 28 SER B  68       89.83     22.34                                   
REMARK 500 28 HIS B  71      109.27    -42.88                                   
REMARK 500 28 ARG B  79      125.44    -35.37                                   
REMARK 500 28 VAL B  81      -40.72   -172.01                                   
REMARK 500 28 SER B  98       60.03   -157.80                                   
REMARK 500 28 VAL B 103      -54.33   -136.91                                   
REMARK 500 28 LEU B 106      -27.37    -37.88                                   
REMARK 500 28 SER B 107       45.43   -153.09                                   
REMARK 500 28 ASP B 109      -55.32     68.98                                   
REMARK 500 28 HIS B 110       45.83    -81.42                                   
REMARK 500 28 ILE B 113      -71.19    -61.29                                   
REMARK 500 28 LYS B 128       30.30    -76.64                                   
REMARK 500 28 ARG B 143       97.19    -60.38                                   
REMARK 500 29 VAL A  31       58.58    -98.34                                   
REMARK 500 29 THR A  54      -52.99    -27.69                                   
REMARK 500 29 ALA A  60      -39.60    -28.07                                   
REMARK 500 29 PRO A  74       13.95    -67.32                                   
REMARK 500 29 VAL A  81     -116.35   -158.72                                   
REMARK 500 29 SER A  98       59.75   -156.62                                   
REMARK 500 29 ASP A 109      -50.15   -162.69                                   
REMARK 500 29 HIS A 110       41.96    -80.32                                   
REMARK 500 29 ILE A 113      -56.50    -14.04                                   
REMARK 500 29 ASN A 139       43.44   -167.52                                   
REMARK 500 29 ILE A 149     -114.63     30.44                                   
REMARK 500 29 ALA B   6       93.75   -160.70                                   
REMARK 500 29 VAL B  14       89.24    -68.63                                   
REMARK 500 29 LYS B  23      -70.81    -56.25                                   
REMARK 500 29 GLU B  24     -133.38   -107.14                                   
REMARK 500 29 ASN B  53       24.07   -143.88                                   
REMARK 500 29 CYS B  57       67.63    -69.26                                   
REMARK 500 29 THR B  58      -53.16   -163.88                                   
REMARK 500 29 ALA B  60      -47.55    -23.81                                   
REMARK 500 29 PRO B  62       46.94    -79.13                                   
REMARK 500 29 PHE B  64       75.64    -66.77                                   
REMARK 500 29 SER B  68      101.64    -30.02                                   
REMARK 500 29 HIS B  71       92.85      5.73                                   
REMARK 500 29 PRO B  74        1.31    -64.62                                   
REMARK 500 29 GLU B  78       31.05    -82.27                                   
REMARK 500 29 VAL B  81      -56.75   -168.23                                   
REMARK 500 29 SER B  98       73.81   -157.78                                   
REMARK 500 29 ASP B 109      -52.69   -169.71                                   
REMARK 500 29 SER B 111     -105.75     49.86                                   
REMARK 500 29 ILE B 112      -23.00    162.87                                   
REMARK 500 29 LYS B 128       39.79    -80.91                                   
REMARK 500 29 ILE B 149      -86.17    -60.12                                   
REMARK 500 30 GLU A  49      -78.84      6.89                                   
REMARK 500 30 ASN A  53       17.91   -161.58                                   
REMARK 500 30 THR A  58      -59.35   -133.79                                   
REMARK 500 30 ALA A  60      -49.70    -23.88                                   
REMARK 500 30 PRO A  62     -136.22    -79.45                                   
REMARK 500 30 HIS A  63       50.35   -106.29                                   
REMARK 500 30 ARG A  69      -90.08   -127.20                                   
REMARK 500 30 VAL A  81      -51.53   -167.89                                   
REMARK 500 30 ASP A  90      172.74    -59.04                                   
REMARK 500 30 SER A  98       57.27   -157.79                                   
REMARK 500 30 VAL A 103      -48.87   -142.07                                   
REMARK 500 30 ASP A 109      -53.69   -152.19                                   
REMARK 500 30 ILE A 112        6.92    -66.77                                   
REMARK 500 30 LYS A 136      -83.05   -102.83                                   
REMARK 500 30 ARG A 143       64.79    -68.90                                   
REMARK 500 30 PRO B  13       37.48    -79.14                                   
REMARK 500 30 LYS B  23       79.13   -152.19                                   
REMARK 500 30 ASN B  53       22.53   -149.13                                   
REMARK 500 30 CYS B  57       70.06   -160.05                                   
REMARK 500 30 THR B  58      -50.73   -163.17                                   
REMARK 500 30 ALA B  60      -41.54    -27.12                                   
REMARK 500 30 PRO B  62     -143.97    -68.88                                   
REMARK 500 30 HIS B  63       42.91   -104.17                                   
REMARK 500 30 SER B  68      102.88    -40.81                                   
REMARK 500 30 HIS B  71       88.39     13.79                                   
REMARK 500 30 PRO B  74        9.56    -64.13                                   
REMARK 500 30 GLU B  78       30.93    -80.38                                   
REMARK 500 30 VAL B  81     -125.44   -156.42                                   
REMARK 500 30 SER B  98       79.09   -158.22                                   
REMARK 500 30 VAL B 103      -49.50   -157.77                                   
REMARK 500 30 SER B 111       79.76     31.81                                   
REMARK 500 30 LYS B 128       49.29    -77.13                                   
REMARK 500 30 ASN B 139       43.57   -165.34                                   
REMARK 500 30 ARG B 143       78.32    -64.06                                   
REMARK 500 30 ILE B 149      -88.03    -72.16                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500  1 ARG A  69         0.12    SIDE_CHAIN                              
REMARK 500  1 PHE B  50         0.10    SIDE_CHAIN                              
REMARK 500  1 PHE B  64         0.09    SIDE_CHAIN                              
REMARK 500  2 PHE A  45         0.07    SIDE_CHAIN                              
REMARK 500  2 ARG B  69         0.17    SIDE_CHAIN                              
REMARK 500  2 ARG B 115         0.08    SIDE_CHAIN                              
REMARK 500  3 PHE A  64         0.09    SIDE_CHAIN                              
REMARK 500  3 ARG A 115         0.30    SIDE_CHAIN                              
REMARK 500  3 PHE B  50         0.08    SIDE_CHAIN                              
REMARK 500  3 PHE B  64         0.11    SIDE_CHAIN                              
REMARK 500  3 ARG B  79         0.10    SIDE_CHAIN                              
REMARK 500  4 ARG A 115         0.11    SIDE_CHAIN                              
REMARK 500  4 PHE B  45         0.09    SIDE_CHAIN                              
REMARK 500  4 PHE B  64         0.08    SIDE_CHAIN                              
REMARK 500  4 HIS B  71         0.08    SIDE_CHAIN                              
REMARK 500  5 ARG A  69         0.11    SIDE_CHAIN                              
REMARK 500  5 ARG A 115         0.09    SIDE_CHAIN                              
REMARK 500  5 PHE B  64         0.09    SIDE_CHAIN                              
REMARK 500  6 ARG A 143         0.13    SIDE_CHAIN                              
REMARK 500  6 HIS B  71         0.10    SIDE_CHAIN                              
REMARK 500  7 PHE A  50         0.12    SIDE_CHAIN                              
REMARK 500  7 PHE A  64         0.11    SIDE_CHAIN                              
REMARK 500  7 ARG A 115         0.10    SIDE_CHAIN                              
REMARK 500  7 PHE B  64         0.09    SIDE_CHAIN                              
REMARK 500  7 ARG B  79         0.10    SIDE_CHAIN                              
REMARK 500  8 PHE A  64         0.09    SIDE_CHAIN                              
REMARK 500  8 ARG A 115         0.10    SIDE_CHAIN                              
REMARK 500  8 ARG A 143         0.09    SIDE_CHAIN                              
REMARK 500  8 ARG B 143         0.09    SIDE_CHAIN                              
REMARK 500  9 HIS A  48         0.17    SIDE_CHAIN                              
REMARK 500  9 ARG A  69         0.08    SIDE_CHAIN                              
REMARK 500  9 ARG A 115         0.08    SIDE_CHAIN                              
REMARK 500  9 ARG A 143         0.09    SIDE_CHAIN                              
REMARK 500  9 ARG B 115         0.13    SIDE_CHAIN                              
REMARK 500  9 ARG B 143         0.09    SIDE_CHAIN                              
REMARK 500 10 HIS A  48         0.14    SIDE_CHAIN                              
REMARK 500 10 ARG A 143         0.12    SIDE_CHAIN                              
REMARK 500 11 PHE A  64         0.09    SIDE_CHAIN                              
REMARK 500 11 PHE B  20         0.09    SIDE_CHAIN                              
REMARK 500 11 PHE B  64         0.16    SIDE_CHAIN                              
REMARK 500 11 ARG B 115         0.09    SIDE_CHAIN                              
REMARK 500 12 ARG A  79         0.11    SIDE_CHAIN                              
REMARK 500 12 ARG A 143         0.09    SIDE_CHAIN                              
REMARK 500 12 HIS B  80         0.11    SIDE_CHAIN                              
REMARK 500 13 PHE A  20         0.08    SIDE_CHAIN                              
REMARK 500 13 PHE A  64         0.11    SIDE_CHAIN                              
REMARK 500 13 ARG B 115         0.10    SIDE_CHAIN                              
REMARK 500 14 ARG A  69         0.08    SIDE_CHAIN                              
REMARK 500 14 PHE B  45         0.10    SIDE_CHAIN                              
REMARK 500 14 HIS B  46         0.07    SIDE_CHAIN                              
REMARK 500 14 PHE B  64         0.08    SIDE_CHAIN                              
REMARK 500 14 HIS B  71         0.11    SIDE_CHAIN                              
REMARK 500 15 PHE A  64         0.12    SIDE_CHAIN                              
REMARK 500 15 ARG B 115         0.11    SIDE_CHAIN                              
REMARK 500 16 PHE A  64         0.08    SIDE_CHAIN                              
REMARK 500 16 ARG A  79         0.16    SIDE_CHAIN                              
REMARK 500 16 ARG A 115         0.11    SIDE_CHAIN                              
REMARK 500 16 ARG A 143         0.08    SIDE_CHAIN                              
REMARK 500 16 ARG B  69         0.11    SIDE_CHAIN                              
REMARK 500 16 HIS B  71         0.07    SIDE_CHAIN                              
REMARK 500 16 ARG B 143         0.13    SIDE_CHAIN                              
REMARK 500 17 ARG A 143         0.13    SIDE_CHAIN                              
REMARK 500 17 ARG B 115         0.14    SIDE_CHAIN                              
REMARK 500 18 ARG A 115         0.11    SIDE_CHAIN                              
REMARK 500 18 PHE B  20         0.08    SIDE_CHAIN                              
REMARK 500 18 PHE B  64         0.09    SIDE_CHAIN                              
REMARK 500 19 ARG B 115         0.14    SIDE_CHAIN                              
REMARK 500 20 PHE A  64         0.11    SIDE_CHAIN                              
REMARK 500 20 ARG A 143         0.09    SIDE_CHAIN                              
REMARK 500 20 ARG B 143         0.10    SIDE_CHAIN                              
REMARK 500 21 PHE A  64         0.10    SIDE_CHAIN                              
REMARK 500 21 ARG A  69         0.10    SIDE_CHAIN                              
REMARK 500 22 PHE A  50         0.16    SIDE_CHAIN                              
REMARK 500 22 PHE A  64         0.09    SIDE_CHAIN                              
REMARK 500 22 ARG A 115         0.10    SIDE_CHAIN                              
REMARK 500 22 ARG B  79         0.11    SIDE_CHAIN                              
REMARK 500 22 ARG B 115         0.13    SIDE_CHAIN                              
REMARK 500 23 ARG A 115         0.07    SIDE_CHAIN                              
REMARK 500 23 ARG B  79         0.08    SIDE_CHAIN                              
REMARK 500 24 ARG A  69         0.11    SIDE_CHAIN                              
REMARK 500 24 ARG B 115         0.12    SIDE_CHAIN                              
REMARK 500 25 PHE A  64         0.10    SIDE_CHAIN                              
REMARK 500 25 ARG A  69         0.08    SIDE_CHAIN                              
REMARK 500 25 PHE B  20         0.10    SIDE_CHAIN                              
REMARK 500 25 PHE B  50         0.15    SIDE_CHAIN                              
REMARK 500 25 PHE B  64         0.09    SIDE_CHAIN                              
REMARK 500 25 HIS B  71         0.07    SIDE_CHAIN                              
REMARK 500 25 ARG B  79         0.09    SIDE_CHAIN                              
REMARK 500 26 ARG A  69         0.09    SIDE_CHAIN                              
REMARK 500 26 ARG B  69         0.11    SIDE_CHAIN                              
REMARK 500 27 HIS A  71         0.11    SIDE_CHAIN                              
REMARK 500 27 ARG B  69         0.07    SIDE_CHAIN                              
REMARK 500 28 PHE A  45         0.12    SIDE_CHAIN                              
REMARK 500 28 PHE B  64         0.09    SIDE_CHAIN                              
REMARK 500 28 ARG B  69         0.12    SIDE_CHAIN                              
REMARK 500 29 PHE A  45         0.12    SIDE_CHAIN                              
REMARK 500 29 PHE A  50         0.14    SIDE_CHAIN                              
REMARK 500 29 ARG A  69         0.13    SIDE_CHAIN                              
REMARK 500 29 PHE B  64         0.08    SIDE_CHAIN                              
REMARK 500 29 HIS B  71         0.08    SIDE_CHAIN                              
REMARK 500 30 ARG A 143         0.10    SIDE_CHAIN                              
REMARK 500 30 HIS B  71         0.10    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620  (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;              
REMARK 620  SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                            
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                           1 CU1 A 154  CU                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS A  46   ND1                                                    
REMARK 620 2 HIS A  48   NE2 133.2                                              
REMARK 620 3 HIS A 120   NE2  91.0 118.9                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                           1  ZN A 155  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS A  63   ND1                                                    
REMARK 620 2 HIS A  71   ND1 105.0                                              
REMARK 620 3 HIS A  80   ND1 111.7 117.2                                        
REMARK 620 4 ASP A  83   OD2 151.8  87.3  83.3                                  
REMARK 620 5 ASP A  83   OD1  94.9 105.5 119.5  57.1                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                           1 CU1 B 154  CU                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS B 120   NE2                                                    
REMARK 620 2 HIS B  48   NE2 120.6                                              
REMARK 620 3 HIS B  46   ND1  89.4 129.5                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                           1  ZN B 155  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP B  83   OD2                                                    
REMARK 620 2 HIS B  63   ND1 153.5                                              
REMARK 620 3 HIS B  71   ND1  85.3 102.9                                        
REMARK 620 4 HIS B  80   ND1  90.3 107.6 116.8                                  
REMARK 620 5 ASP B  83   OD1  55.2  98.3 102.8 125.0                            
REMARK 620 N                    1     2     3     4                             
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CU1 A 154                 
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN A 155                  
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CU1 B 154                 
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 155                  
DBREF  1L3N A    1   153  UNP    P00441   SODC_HUMAN       1    153             
DBREF  1L3N B    1   153  UNP    P00441   SODC_HUMAN       1    153             
SEQADV 1L3N ALA A    6  UNP  P00441    CYS     6 ENGINEERED                     
SEQADV 1L3N SER A  111  UNP  P00441    CYS   111 ENGINEERED                     
SEQADV 1L3N ALA B    6  UNP  P00441    CYS     6 ENGINEERED                     
SEQADV 1L3N SER B  111  UNP  P00441    CYS   111 ENGINEERED                     
SEQRES   1 A  153  ALA THR LYS ALA VAL ALA VAL LEU LYS GLY ASP GLY PRO          
SEQRES   2 A  153  VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER ASN          
SEQRES   3 A  153  GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU THR          
SEQRES   4 A  153  GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY ASP          
SEQRES   5 A  153  ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE ASN          
SEQRES   6 A  153  PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU GLU          
SEQRES   7 A  153  ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP LYS          
SEQRES   8 A  153  ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL ILE          
SEQRES   9 A  153  SER LEU SER GLY ASP HIS SER ILE ILE GLY ARG THR LEU          
SEQRES  10 A  153  VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY GLY          
SEQRES  11 A  153  ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER ARG          
SEQRES  12 A  153  LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                      
SEQRES   1 B  153  ALA THR LYS ALA VAL ALA VAL LEU LYS GLY ASP GLY PRO          
SEQRES   2 B  153  VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER ASN          
SEQRES   3 B  153  GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU THR          
SEQRES   4 B  153  GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY ASP          
SEQRES   5 B  153  ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE ASN          
SEQRES   6 B  153  PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU GLU          
SEQRES   7 B  153  ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP LYS          
SEQRES   8 B  153  ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL ILE          
SEQRES   9 B  153  SER LEU SER GLY ASP HIS SER ILE ILE GLY ARG THR LEU          
SEQRES  10 B  153  VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY GLY          
SEQRES  11 B  153  ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER ARG          
SEQRES  12 B  153  LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                      
HET    CU1  A 154       1                                                       
HET     ZN  A 155       1                                                       
HET    CU1  B 154       1                                                       
HET     ZN  B 155       1                                                       
HETNAM     CU1 COPPER (I) ION                                                   
HETNAM      ZN ZINC ION                                                         
FORMUL   3  CU1    2(CU 1+)                                                     
FORMUL   4   ZN    2(ZN 2+)                                                     
HELIX    1   1 GLU A  132  LYS A  136  5                                   5    
HELIX    2   2 ASN B  131  THR B  137  1                                   7    
SHEET    1   A 4 LYS A   3  LYS A   9  0                                        
SHEET    2   A 4 GLN A  15  GLN A  22 -1  O  ILE A  18   N  ALA A   6           
SHEET    3   A 4 VAL A  29  ILE A  35 -1  O  TRP A  32   N  ASN A  19           
SHEET    4   A 4 ALA A  95  VAL A  97 -1  O  VAL A  97   N  GLY A  33           
SHEET    1   B 4 LYS A   3  LYS A   9  0                                        
SHEET    2   B 4 GLN A  15  GLN A  22 -1  O  ILE A  18   N  ALA A   6           
SHEET    3   B 4 VAL A  29  ILE A  35 -1  O  TRP A  32   N  ASN A  19           
SHEET    4   B 4 GLU A 100  ASP A 101 -1  O  ASP A 101   N  VAL A  29           
SHEET    1   C 4 ASP A  83  ALA A  89  0                                        
SHEET    2   C 4 GLY A  41  HIS A  46 -1  N  GLY A  41   O  ALA A  89           
SHEET    3   C 4 THR A 116  HIS A 120 -1  O  VAL A 118   N  HIS A  46           
SHEET    4   C 4 ARG A 143  VAL A 148 -1  O  ALA A 145   N  VAL A 119           
SHEET    1   D 5 VAL B  94  ASP B 101  0                                        
SHEET    2   D 5 VAL B  29  LYS B  36 -1  N  VAL B  29   O  ASP B 101           
SHEET    3   D 5 GLN B  15  GLN B  22 -1  N  ASN B  19   O  TRP B  32           
SHEET    4   D 5 LYS B   3  LYS B   9 -1  N  ALA B   4   O  PHE B  20           
SHEET    5   D 5 GLY B 150  ILE B 151 -1  O  GLY B 150   N  VAL B   5           
SHEET    1   E 2 GLY B  41  HIS B  43  0                                        
SHEET    2   E 2 VAL B  87  ALA B  89 -1  O  ALA B  89   N  GLY B  41           
SHEET    1   F 3 PHE B  45  HIS B  48  0                                        
SHEET    2   F 3 THR B 116  VAL B 119 -1  O  THR B 116   N  HIS B  48           
SHEET    3   F 3 ALA B 145  VAL B 148 -1  O  GLY B 147   N  LEU B 117           
SSBOND   1 CYS A   57    CYS A  146                          1555   1555  2.08  
SSBOND   2 CYS B   57    CYS B  146                          1555   1555  2.08  
LINK        CU   CU1 A 154                 ND1 HIS A  46     1555   1555  2.08  
LINK        CU   CU1 A 154                 NE2 HIS A  48     1555   1555  2.06  
LINK        CU   CU1 A 154                 NE2 HIS A 120     1555   1555  2.07  
LINK        ZN    ZN A 155                 ND1 HIS A  63     1555   1555  2.06  
LINK        ZN    ZN A 155                 ND1 HIS A  71     1555   1555  2.05  
LINK        ZN    ZN A 155                 ND1 HIS A  80     1555   1555  2.07  
LINK        ZN    ZN A 155                 OD2 ASP A  83     1555   1555  2.58  
LINK        ZN    ZN A 155                 OD1 ASP A  83     1555   1555  1.85  
LINK        CU   CU1 B 154                 NE2 HIS B 120     1555   1555  2.07  
LINK        CU   CU1 B 154                 NE2 HIS B  48     1555   1555  2.04  
LINK        CU   CU1 B 154                 ND1 HIS B  46     1555   1555  2.03  
LINK        ZN    ZN B 155                 OD2 ASP B  83     1555   1555  2.64  
LINK        ZN    ZN B 155                 ND1 HIS B  63     1555   1555  2.06  
LINK        ZN    ZN B 155                 ND1 HIS B  71     1555   1555  2.04  
LINK        ZN    ZN B 155                 ND1 HIS B  80     1555   1555  2.03  
LINK        ZN    ZN B 155                 OD1 ASP B  83     1555   1555  1.94  
SITE     1 AC1  5 HIS A  46  HIS A  48  HIS A  63  VAL A 118                    
SITE     2 AC1  5 HIS A 120                                                     
SITE     1 AC2  5 HIS A  63  HIS A  71  HIS A  80  ASP A  83                    
SITE     2 AC2  5 LYS A 136                                                     
SITE     1 AC3  5 HIS B  46  HIS B  48  HIS B  63  VAL B 118                    
SITE     2 AC3  5 HIS B 120                                                     
SITE     1 AC4  4 HIS B  63  HIS B  71  HIS B  80  ASP B  83                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system