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Database: PDB
Entry: 1PJL
LinkDB: 1PJL
Original site: 1PJL 
HEADER    OXIDOREDUCTASE                          03-JUN-03   1PJL              
TITLE     CRYSTAL STRUCTURE OF HUMAN M-NAD-ME IN TERNARY COMPLEX WITH           
TITLE    2 NAD AND LU3+                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL;                 
COMPND   3 CHAIN: A, B, C, D, E, F, G, H;                                       
COMPND   4 SYNONYM: NAD-ME, MALIC ENZYME 2;                                     
COMPND   5 EC: 1.1.1.38;                                                        
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: ME2;                                                           
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    OXIDOREDUCTASE                                                        
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    Z.YANG,R.BATRA,D.L.FLOYD,H.-C.HUNG,G.-G.CHANG,L.TONG                  
REVDAT   2   24-FEB-09 1PJL    1       VERSN                                    
REVDAT   1   17-JUN-03 1PJL    0                                                
JRNL        AUTH   Z.YANG,R.BATRA,D.L.FLOYD,H.-C.HUNG,G.-G.CHANG,               
JRNL        AUTH 2 L.TONG                                                       
JRNL        TITL   POTENT AND COMPETITIVE INHIBITION OF MALIC ENZYMES           
JRNL        TITL 2 BY LANTHANIDE IONS                                           
JRNL        REF    BIOCHEM.BIOPHYS.RES.COMMUN.   V. 274   440 2000              
JRNL        REFN                   ISSN 0006-291X                               
JRNL        PMID   10913357                                                     
JRNL        DOI    10.1006/BBRC.2000.3163                                       
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : X-PLOR                                               
REMARK   3   AUTHORS     : BRUNGER                                              
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.90                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 20.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 2.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL                           
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL                           
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : NULL                           
REMARK   3   NUMBER OF REFLECTIONS             : 100233                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : NULL                            
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.204                           
REMARK   3   FREE R VALUE                     : 0.263                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL                            
REMARK   3   FREE R VALUE TEST SET COUNT      : 7500                            
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL                         
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL                         
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL                         
REMARK   3   BIN R VALUE           (WORKING SET) : NULL                         
REMARK   3   BIN FREE R VALUE                    : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL                         
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL                         
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 34752                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 712                                     
REMARK   3   SOLVENT ATOMS            : 63                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL                            
REMARK   3   ESD FROM SIGMAA              (A) : NULL                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.008                           
REMARK   3   BOND ANGLES            (DEGREES) : NULL                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL                            
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : NULL                                      
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1PJL COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 05-JUN-03.                  
REMARK 100 THE RCSB ID CODE IS RCSB019366.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 01-NOV-99                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 7.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : CHESS                              
REMARK 200  BEAMLINE                       : F1                                 
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9                                
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 4                     
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO                              
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 105876                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.900                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 0.8                                
REMARK 200  DATA REDUNDANCY                : 3.000                              
REMARK 200  R MERGE                    (I) : 0.05300                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: REPLACE                                               
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 54.99                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.73                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM HEPES, 6% PEG8000, 5% MPD,        
REMARK 280  0.5 MM LUCL3, PH 7.0, VAPOR DIFFUSION, HANGING DROP,                
REMARK 280  TEMPERATURE 277K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 21950 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 80050 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -114.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 22110 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 80110 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -108.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, G, H                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MSE A     1                                                      
REMARK 465     LEU A     2                                                      
REMARK 465     SER A     3                                                      
REMARK 465     ARG A     4                                                      
REMARK 465     LEU A     5                                                      
REMARK 465     ARG A     6                                                      
REMARK 465     VAL A     7                                                      
REMARK 465     VAL A     8                                                      
REMARK 465     SER A     9                                                      
REMARK 465     THR A    10                                                      
REMARK 465     THR A    11                                                      
REMARK 465     CYS A    12                                                      
REMARK 465     THR A    13                                                      
REMARK 465     LEU A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     CYS A    16                                                      
REMARK 465     ARG A    17                                                      
REMARK 465     HIS A    18                                                      
REMARK 465     LEU A    19                                                      
REMARK 465     HIS A    20                                                      
REMARK 465     ILE A    21                                                      
REMARK 465     LYS A    22                                                      
REMARK 465     GLU A   574                                                      
REMARK 465     SER A   575                                                      
REMARK 465     ALA A   576                                                      
REMARK 465     SER A   577                                                      
REMARK 465     SER A   578                                                      
REMARK 465     PRO A   579                                                      
REMARK 465     PRO A   580                                                      
REMARK 465     VAL A   581                                                      
REMARK 465     ILE A   582                                                      
REMARK 465     THR A   583                                                      
REMARK 465     GLU A   584                                                      
REMARK 465     MSE B  1001                                                      
REMARK 465     LEU B  1002                                                      
REMARK 465     SER B  1003                                                      
REMARK 465     ARG B  1004                                                      
REMARK 465     LEU B  1005                                                      
REMARK 465     ARG B  1006                                                      
REMARK 465     VAL B  1007                                                      
REMARK 465     VAL B  1008                                                      
REMARK 465     SER B  1009                                                      
REMARK 465     THR B  1010                                                      
REMARK 465     THR B  1011                                                      
REMARK 465     CYS B  1012                                                      
REMARK 465     THR B  1013                                                      
REMARK 465     LEU B  1014                                                      
REMARK 465     ALA B  1015                                                      
REMARK 465     CYS B  1016                                                      
REMARK 465     ARG B  1017                                                      
REMARK 465     HIS B  1018                                                      
REMARK 465     LEU B  1019                                                      
REMARK 465     HIS B  1020                                                      
REMARK 465     ILE B  1021                                                      
REMARK 465     LYS B  1022                                                      
REMARK 465     GLU B  1574                                                      
REMARK 465     SER B  1575                                                      
REMARK 465     ALA B  1576                                                      
REMARK 465     SER B  1577                                                      
REMARK 465     SER B  1578                                                      
REMARK 465     PRO B  1579                                                      
REMARK 465     PRO B  1580                                                      
REMARK 465     VAL B  1581                                                      
REMARK 465     ILE B  1582                                                      
REMARK 465     THR B  1583                                                      
REMARK 465     GLU B  1584                                                      
REMARK 465     MSE C  2001                                                      
REMARK 465     LEU C  2002                                                      
REMARK 465     SER C  2003                                                      
REMARK 465     ARG C  2004                                                      
REMARK 465     LEU C  2005                                                      
REMARK 465     ARG C  2006                                                      
REMARK 465     VAL C  2007                                                      
REMARK 465     VAL C  2008                                                      
REMARK 465     SER C  2009                                                      
REMARK 465     THR C  2010                                                      
REMARK 465     THR C  2011                                                      
REMARK 465     CYS C  2012                                                      
REMARK 465     THR C  2013                                                      
REMARK 465     LEU C  2014                                                      
REMARK 465     ALA C  2015                                                      
REMARK 465     CYS C  2016                                                      
REMARK 465     ARG C  2017                                                      
REMARK 465     HIS C  2018                                                      
REMARK 465     LEU C  2019                                                      
REMARK 465     HIS C  2020                                                      
REMARK 465     ILE C  2021                                                      
REMARK 465     LYS C  2022                                                      
REMARK 465     GLU C  2574                                                      
REMARK 465     SER C  2575                                                      
REMARK 465     ALA C  2576                                                      
REMARK 465     SER C  2577                                                      
REMARK 465     SER C  2578                                                      
REMARK 465     PRO C  2579                                                      
REMARK 465     PRO C  2580                                                      
REMARK 465     VAL C  2581                                                      
REMARK 465     ILE C  2582                                                      
REMARK 465     THR C  2583                                                      
REMARK 465     GLU C  2584                                                      
REMARK 465     MSE D  3001                                                      
REMARK 465     LEU D  3002                                                      
REMARK 465     SER D  3003                                                      
REMARK 465     ARG D  3004                                                      
REMARK 465     LEU D  3005                                                      
REMARK 465     ARG D  3006                                                      
REMARK 465     VAL D  3007                                                      
REMARK 465     VAL D  3008                                                      
REMARK 465     SER D  3009                                                      
REMARK 465     THR D  3010                                                      
REMARK 465     THR D  3011                                                      
REMARK 465     CYS D  3012                                                      
REMARK 465     THR D  3013                                                      
REMARK 465     LEU D  3014                                                      
REMARK 465     ALA D  3015                                                      
REMARK 465     CYS D  3016                                                      
REMARK 465     ARG D  3017                                                      
REMARK 465     HIS D  3018                                                      
REMARK 465     LEU D  3019                                                      
REMARK 465     HIS D  3020                                                      
REMARK 465     ILE D  3021                                                      
REMARK 465     LYS D  3022                                                      
REMARK 465     GLU D  3574                                                      
REMARK 465     SER D  3575                                                      
REMARK 465     ALA D  3576                                                      
REMARK 465     SER D  3577                                                      
REMARK 465     SER D  3578                                                      
REMARK 465     PRO D  3579                                                      
REMARK 465     PRO D  3580                                                      
REMARK 465     VAL D  3581                                                      
REMARK 465     ILE D  3582                                                      
REMARK 465     THR D  3583                                                      
REMARK 465     GLU D  3584                                                      
REMARK 465     MSE E  4001                                                      
REMARK 465     LEU E  4002                                                      
REMARK 465     SER E  4003                                                      
REMARK 465     ARG E  4004                                                      
REMARK 465     LEU E  4005                                                      
REMARK 465     ARG E  4006                                                      
REMARK 465     VAL E  4007                                                      
REMARK 465     VAL E  4008                                                      
REMARK 465     SER E  4009                                                      
REMARK 465     THR E  4010                                                      
REMARK 465     THR E  4011                                                      
REMARK 465     CYS E  4012                                                      
REMARK 465     THR E  4013                                                      
REMARK 465     LEU E  4014                                                      
REMARK 465     ALA E  4015                                                      
REMARK 465     CYS E  4016                                                      
REMARK 465     ARG E  4017                                                      
REMARK 465     HIS E  4018                                                      
REMARK 465     LEU E  4019                                                      
REMARK 465     HIS E  4020                                                      
REMARK 465     ILE E  4021                                                      
REMARK 465     LYS E  4022                                                      
REMARK 465     GLU E  4574                                                      
REMARK 465     SER E  4575                                                      
REMARK 465     ALA E  4576                                                      
REMARK 465     SER E  4577                                                      
REMARK 465     SER E  4578                                                      
REMARK 465     PRO E  4579                                                      
REMARK 465     PRO E  4580                                                      
REMARK 465     VAL E  4581                                                      
REMARK 465     ILE E  4582                                                      
REMARK 465     THR E  4583                                                      
REMARK 465     GLU E  4584                                                      
REMARK 465     MSE F  5001                                                      
REMARK 465     LEU F  5002                                                      
REMARK 465     SER F  5003                                                      
REMARK 465     ARG F  5004                                                      
REMARK 465     LEU F  5005                                                      
REMARK 465     ARG F  5006                                                      
REMARK 465     VAL F  5007                                                      
REMARK 465     VAL F  5008                                                      
REMARK 465     SER F  5009                                                      
REMARK 465     THR F  5010                                                      
REMARK 465     THR F  5011                                                      
REMARK 465     CYS F  5012                                                      
REMARK 465     THR F  5013                                                      
REMARK 465     LEU F  5014                                                      
REMARK 465     ALA F  5015                                                      
REMARK 465     CYS F  5016                                                      
REMARK 465     ARG F  5017                                                      
REMARK 465     HIS F  5018                                                      
REMARK 465     LEU F  5019                                                      
REMARK 465     HIS F  5020                                                      
REMARK 465     ILE F  5021                                                      
REMARK 465     LYS F  5022                                                      
REMARK 465     GLU F  5574                                                      
REMARK 465     SER F  5575                                                      
REMARK 465     ALA F  5576                                                      
REMARK 465     SER F  5577                                                      
REMARK 465     SER F  5578                                                      
REMARK 465     PRO F  5579                                                      
REMARK 465     PRO F  5580                                                      
REMARK 465     VAL F  5581                                                      
REMARK 465     ILE F  5582                                                      
REMARK 465     THR F  5583                                                      
REMARK 465     GLU F  5584                                                      
REMARK 465     MSE G  6001                                                      
REMARK 465     LEU G  6002                                                      
REMARK 465     SER G  6003                                                      
REMARK 465     ARG G  6004                                                      
REMARK 465     LEU G  6005                                                      
REMARK 465     ARG G  6006                                                      
REMARK 465     VAL G  6007                                                      
REMARK 465     VAL G  6008                                                      
REMARK 465     SER G  6009                                                      
REMARK 465     THR G  6010                                                      
REMARK 465     THR G  6011                                                      
REMARK 465     CYS G  6012                                                      
REMARK 465     THR G  6013                                                      
REMARK 465     LEU G  6014                                                      
REMARK 465     ALA G  6015                                                      
REMARK 465     CYS G  6016                                                      
REMARK 465     ARG G  6017                                                      
REMARK 465     HIS G  6018                                                      
REMARK 465     LEU G  6019                                                      
REMARK 465     HIS G  6020                                                      
REMARK 465     ILE G  6021                                                      
REMARK 465     LYS G  6022                                                      
REMARK 465     GLU G  6574                                                      
REMARK 465     SER G  6575                                                      
REMARK 465     ALA G  6576                                                      
REMARK 465     SER G  6577                                                      
REMARK 465     SER G  6578                                                      
REMARK 465     PRO G  6579                                                      
REMARK 465     PRO G  6580                                                      
REMARK 465     VAL G  6581                                                      
REMARK 465     ILE G  6582                                                      
REMARK 465     THR G  6583                                                      
REMARK 465     GLU G  6584                                                      
REMARK 465     MSE H  7001                                                      
REMARK 465     LEU H  7002                                                      
REMARK 465     SER H  7003                                                      
REMARK 465     ARG H  7004                                                      
REMARK 465     LEU H  7005                                                      
REMARK 465     ARG H  7006                                                      
REMARK 465     VAL H  7007                                                      
REMARK 465     VAL H  7008                                                      
REMARK 465     SER H  7009                                                      
REMARK 465     THR H  7010                                                      
REMARK 465     THR H  7011                                                      
REMARK 465     CYS H  7012                                                      
REMARK 465     THR H  7013                                                      
REMARK 465     LEU H  7014                                                      
REMARK 465     ALA H  7015                                                      
REMARK 465     CYS H  7016                                                      
REMARK 465     ARG H  7017                                                      
REMARK 465     HIS H  7018                                                      
REMARK 465     LEU H  7019                                                      
REMARK 465     HIS H  7020                                                      
REMARK 465     ILE H  7021                                                      
REMARK 465     LYS H  7022                                                      
REMARK 465     GLU H  7574                                                      
REMARK 465     SER H  7575                                                      
REMARK 465     ALA H  7576                                                      
REMARK 465     SER H  7577                                                      
REMARK 465     SER H  7578                                                      
REMARK 465     PRO H  7579                                                      
REMARK 465     PRO H  7580                                                      
REMARK 465     VAL H  7581                                                      
REMARK 465     ILE H  7582                                                      
REMARK 465     THR H  7583                                                      
REMARK 465     GLU H  7584                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;            
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A 484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B1484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C2484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D3484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E4484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG F5484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG G6484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H7484    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    LYS D  3268     O    HOH D  8049              2.09            
REMARK 500   OD2  ASP A   375     OD2  ASP A   379              2.14            
REMARK 500   OG   SER G  6489     OH   TYR G  6533              2.14            
REMARK 500   O    LEU A   310     O    PHE A   344              2.17            
REMARK 500   O    ALA D  3289     OG1  THR D  3499              2.17            
REMARK 500   O    GLU B  1152     OH   TYR B  1246              2.17            
REMARK 500   O    LYS F  5496     OG   SER F  5500              2.18            
REMARK 500   O    LEU A   512     O    HOH A  8037              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A  36       21.30   -149.52                                   
REMARK 500    PRO A  56      -11.25    -45.48                                   
REMARK 500    GLN A  89      -80.08    -62.92                                   
REMARK 500    GLU A  90       19.77    -60.13                                   
REMARK 500    GLN A 101        4.05    -69.75                                   
REMARK 500    ILE A 104      -60.76    -20.00                                   
REMARK 500    ARG A 128      -36.27   -137.00                                   
REMARK 500    LYS A 131      -55.19   -134.13                                   
REMARK 500    LEU A 167     -142.10     27.12                                   
REMARK 500    PRO A 180      -37.71    -39.95                                   
REMARK 500    ASP A 196        9.32    -63.16                                   
REMARK 500    THR A 228     -169.52    -59.08                                   
REMARK 500    ASP A 236      -71.51    -58.49                                   
REMARK 500    ASP A 244      -83.17    -55.95                                   
REMARK 500    ASP A 256       67.36     -5.17                                   
REMARK 500    ASN A 259      -61.26     -9.66                                   
REMARK 500    LYS A 268      -93.07    -64.54                                   
REMARK 500    TYR A 269       -3.80    -53.95                                   
REMARK 500    ILE A 280      -78.02   -116.78                                   
REMARK 500    ALA A 294      -77.80    -71.77                                   
REMARK 500    LYS A 296      -31.87    -40.00                                   
REMARK 500    SER A 299       74.32     62.89                                   
REMARK 500    PRO A 301       83.51    -26.81                                   
REMARK 500    ILE A 302      -61.77     -4.54                                   
REMARK 500    GLU A 314      -83.47     23.49                                   
REMARK 500    ALA A 320      -42.03    -23.68                                   
REMARK 500    ILE A 323      -75.53    -65.76                                   
REMARK 500    LYS A 339       -3.44    -59.09                                   
REMARK 500    TYR A 347       30.53    -64.17                                   
REMARK 500    LEU A 350       83.15    -69.68                                   
REMARK 500    LYS A 352      104.19    -38.42                                   
REMARK 500    GLU A 371      -75.06    -17.61                                   
REMARK 500    ASN A 382      -71.02    -71.98                                   
REMARK 500    ILE A 383      -43.77    -27.28                                   
REMARK 500    LYS A 385       42.49     72.50                                   
REMARK 500    ALA A 393      -19.12   -143.14                                   
REMARK 500    ARG A 397       82.33    -61.96                                   
REMARK 500    ILE A 410      -17.18    -48.99                                   
REMARK 500    ARG A 413       63.99   -157.81                                   
REMARK 500    PRO A 422     -162.88    -73.62                                   
REMARK 500    CYS A 428     -145.19   -172.59                                   
REMARK 500    GLU A 431      -74.70    -48.07                                   
REMARK 500    GLU A 432       -9.14    -47.69                                   
REMARK 500    ALA A 433      -72.10    -96.09                                   
REMARK 500    GLU A 438       -5.65     67.26                                   
REMARK 500    PRO A 451      167.38    -46.99                                   
REMARK 500    ILE A 470      -89.91    -84.90                                   
REMARK 500    PHE A 471      -47.21    -26.38                                   
REMARK 500    ILE A 479      -82.88    -64.91                                   
REMARK 500    LEU A 480       -8.37    -51.33                                   
REMARK 500    SER A 500       13.79    -59.79                                   
REMARK 500    ASN A 518       38.12    -94.34                                   
REMARK 500    GLN A 520      -77.46    -62.88                                   
REMARK 500    ILE A 528      -73.17    -46.50                                   
REMARK 500    PRO A 546     -179.86    -59.36                                   
REMARK 500    ARG A 556       55.95    -95.84                                   
REMARK 500    PRO A 567      178.68    -56.45                                   
REMARK 500    PRO B1055      151.36    -48.36                                   
REMARK 500    PRO B1056       22.76    -70.78                                   
REMARK 500    ASN B1092       91.01   -167.95                                   
REMARK 500    GLU B1093      -93.27    -44.83                                   
REMARK 500    LYS B1094      -66.91    -13.86                                   
REMARK 500    LEU B1100      -89.03    -48.41                                   
REMARK 500    GLN B1101      -14.47    -48.46                                   
REMARK 500    TYR B1112     -136.73   -132.31                                   
REMARK 500    PHE B1127      134.72    -16.16                                   
REMARK 500    ARG B1128      -39.72   -136.70                                   
REMARK 500    ASP B1148       -6.07    -49.18                                   
REMARK 500    LEU B1167     -167.41     62.34                                   
REMARK 500    ASP B1171      110.48    -37.56                                   
REMARK 500    THR B1188      -72.08    -66.51                                   
REMARK 500    TYR B1222       59.64    -63.55                                   
REMARK 500    ARG B1225      109.99    -49.56                                   
REMARK 500    THR B1228      178.24    -52.27                                   
REMARK 500    TYR B1231      -70.63    -58.52                                   
REMARK 500    ASN B1249       -8.44    -55.57                                   
REMARK 500    ASP B1256       55.46     35.38                                   
REMARK 500    ASN B1259     -104.08     29.40                                   
REMARK 500    HIS B1260      -84.95      5.56                                   
REMARK 500    LEU B1266      -71.19    -62.64                                   
REMARK 500    LYS B1268     -104.22    -56.13                                   
REMARK 500    TYR B1269      -15.77    -49.03                                   
REMARK 500    CYS B1274       40.04    -86.73                                   
REMARK 500    ASP B1279       25.71    -77.01                                   
REMARK 500    ILE B1280      -67.20   -151.86                                   
REMARK 500    ALA B1284      -77.96    -34.86                                   
REMARK 500    SER B1299       86.21     52.55                                   
REMARK 500    PRO B1301       93.15    -23.49                                   
REMARK 500    ILE B1302      -81.98      4.86                                   
REMARK 500    SER B1303      -51.86    -14.08                                   
REMARK 500    GLU B1314      -89.51     44.24                                   
REMARK 500    ILE B1319      -73.02    -41.76                                   
REMARK 500    ALA B1320      -66.30    -24.97                                   
REMARK 500    ASN B1330       41.55    -93.89                                   
REMARK 500    LEU B1332     -167.70   -128.77                                   
REMARK 500    GLN B1335      -74.41    -45.14                                   
REMARK 500    ALA B1337      -74.70    -39.16                                   
REMARK 500    PRO B1364       11.19    -56.23                                   
REMARK 500    HIS B1367     -179.39    -60.58                                   
REMARK 500    GLU B1371      -70.03    -16.28                                   
REMARK 500    PHE B1399       56.45    -98.50                                   
REMARK 500    THR B1400      165.32    -46.07                                   
REMARK 500    ILE B1404      -74.67    -71.79                                   
REMARK 500    PRO B1422     -148.54    -63.83                                   
REMARK 500    CYS B1428     -146.00   -171.79                                   
REMARK 500    GLU B1431      -70.54    -61.76                                   
REMARK 500    GLU B1432       -6.57    -52.52                                   
REMARK 500    ALA B1433      -69.04    -95.56                                   
REMARK 500    LEU B1436       23.43    -65.42                                   
REMARK 500    THR B1437        8.91   -157.22                                   
REMARK 500    ALA B1444      115.62   -169.92                                   
REMARK 500    PRO B1451      155.11    -26.75                                   
REMARK 500    ASP B1456       40.16    -88.48                                   
REMARK 500    ILE B1470      -77.80   -111.05                                   
REMARK 500    PHE B1471      -38.20    -35.00                                   
REMARK 500    PRO B1472      -71.66    -60.47                                   
REMARK 500    ILE B1479      -74.27    -55.59                                   
REMARK 500    THR B1483      102.31    -56.67                                   
REMARK 500    GLN B1520      -75.14    -63.26                                   
REMARK 500    TYR B1533      -72.10    -59.57                                   
REMARK 500    ALA B1550      -75.36    -52.92                                   
REMARK 500    TYR B1552      -70.58    -52.03                                   
REMARK 500    LYS B1554      -15.46    -45.53                                   
REMARK 500    ARG B1556       16.13    -57.29                                   
REMARK 500    TYR B1562      159.32    -49.44                                   
REMARK 500    TYR B1570      137.36   -170.24                                   
REMARK 500    ASN C2035      133.56    -36.03                                   
REMARK 500    PRO C2056       28.52    -56.14                                   
REMARK 500    ASP C2103       37.08   -157.25                                   
REMARK 500    TYR C2112     -136.53   -127.58                                   
REMARK 500    TYR C2123      145.99    -38.42                                   
REMARK 500    ARG C2128      -85.08   -136.42                                   
REMARK 500    LYS C2131      -38.64   -132.72                                   
REMARK 500    VAL C2143      -39.80    -37.75                                   
REMARK 500    LYS C2156      -30.29   -132.05                                   
REMARK 500    ILE C2166       95.56    -63.13                                   
REMARK 500    LEU C2167     -150.41     48.60                                   
REMARK 500    LEU C2172       10.07   -141.36                                   
REMARK 500    LEU C2199      107.17   -170.25                                   
REMARK 500    ARG C2225      166.83    -47.14                                   
REMARK 500    ASP C2256       82.29     31.35                                   
REMARK 500    ASN C2259      -96.71     20.62                                   
REMARK 500    HIS C2260      -54.69    -20.16                                   
REMARK 500    ASP C2279      -14.08    -45.35                                   
REMARK 500    ILE C2280      -74.21   -119.64                                   
REMARK 500    THR C2283      -71.34    -68.85                                   
REMARK 500    ALA C2284      -35.46    -34.03                                   
REMARK 500    LEU C2291      -39.78    -36.37                                   
REMARK 500    LEU C2292      -80.38    -57.37                                   
REMARK 500    ALA C2293      -26.98    -37.78                                   
REMARK 500    PRO C2301       85.07    -29.04                                   
REMARK 500    ILE C2302      -71.54      2.05                                   
REMARK 500    SER C2303      -34.79    -35.30                                   
REMARK 500    GLU C2314      -73.07     16.32                                   
REMARK 500    ALA C2316      -71.71    -60.58                                   
REMARK 500    ILE C2323      -70.24    -73.37                                   
REMARK 500    GLU C2329       -9.42    -54.38                                   
REMARK 500    GLU C2334      -51.23    -25.94                                   
REMARK 500    TYR C2347       28.07    -69.86                                   
REMARK 500    ARG C2354      150.97    -47.78                                   
REMARK 500    ALA C2356     -177.88    -58.08                                   
REMARK 500    THR C2366       78.91   -101.47                                   
REMARK 500    ALA C2369      130.83    -31.46                                   
REMARK 500    PRO C2374     -173.90    -67.10                                   
REMARK 500    ASP C2375      -22.04   -148.33                                   
REMARK 500    VAL C2381      -52.60    -22.44                                   
REMARK 500    ASN C2382      -84.88    -62.64                                   
REMARK 500    ILE C2383      -52.78    -20.46                                   
REMARK 500    LYS C2385       76.85     66.31                                   
REMARK 500    THR C2400      171.95    -49.54                                   
REMARK 500    ILE C2404      -73.67    -43.92                                   
REMARK 500    ARG C2405      -19.12    -43.16                                   
REMARK 500    ARG C2413       88.07   -161.11                                   
REMARK 500    THR C2423        9.61    -54.13                                   
REMARK 500    ALA C2426      152.66    -37.57                                   
REMARK 500    CYS C2428     -171.26   -178.92                                   
REMARK 500    GLU C2431      -71.94    -55.80                                   
REMARK 500    THR C2437       -3.75   -141.03                                   
REMARK 500    PRO C2451      167.74    -46.04                                   
REMARK 500    THR C2455       -7.66    -38.34                                   
REMARK 500    PRO C2462     -171.04    -68.64                                   
REMARK 500    VAL C2468       -9.47    -57.20                                   
REMARK 500    ILE C2470      -80.61   -113.57                                   
REMARK 500    PHE C2471      -41.03    -25.53                                   
REMARK 500    ALA C2495      -70.99    -44.76                                   
REMARK 500    LEU C2498      -79.12    -57.52                                   
REMARK 500    SER C2500       25.48    -61.33                                   
REMARK 500    LEU C2512       30.81    -99.85                                   
REMARK 500    PRO C2515      125.82    -39.93                                   
REMARK 500    LEU C2516        2.45    -62.51                                   
REMARK 500    ASN C2518       45.92   -106.14                                   
REMARK 500    GLN C2520      -90.60    -61.88                                   
REMARK 500    ALA C2527      -77.93    -51.65                                   
REMARK 500    ILE C2528      -84.90    -26.61                                   
REMARK 500    LYS C2529      -25.17    -34.66                                   
REMARK 500    ALA C2550      -71.80    -52.56                                   
REMARK 500    TYR C2552      -77.98    -60.97                                   
REMARK 500    TYR C2562      160.59    -42.71                                   
REMARK 500    TYR C2570      125.07    159.87                                   
REMARK 500    PRO D3055      157.06    -46.27                                   
REMARK 500    PRO D3056       27.90    -76.57                                   
REMARK 500    LEU D3066      -72.21    -48.58                                   
REMARK 500    ARG D3067      -59.06    -24.95                                   
REMARK 500    SER D3077      149.54    -33.81                                   
REMARK 500    ARG D3091      -54.13   -126.51                                   
REMARK 500    LEU D3095      -73.11    -49.73                                   
REMARK 500    PHE D3096      -75.97    -16.30                                   
REMARK 500    GLN D3101       38.27    -75.46                                   
REMARK 500    ASP D3103       56.40   -162.33                                   
REMARK 500    TYR D3112     -139.64   -143.45                                   
REMARK 500    TYR D3123      166.52    -39.14                                   
REMARK 500    ARG D3128      -51.29   -138.80                                   
REMARK 500    PRO D3130      171.05    -59.65                                   
REMARK 500    SER D3138       13.28    -62.70                                   
REMARK 500    VAL D3143      -58.73    -27.46                                   
REMARK 500    ILE D3166       98.81    -55.66                                   
REMARK 500    LEU D3167     -150.26     43.96                                   
REMARK 500    ASP D3171       97.00    -43.34                                   
REMARK 500    CYS D3202      109.77   -164.33                                   
REMARK 500    VAL D3205       63.87   -151.83                                   
REMARK 500    THR D3207     -169.78   -177.24                                   
REMARK 500    ASP D3208      -61.27   -122.87                                   
REMARK 500    ASN D3209      117.19    -35.26                                   
REMARK 500    GLN D3223     -176.69    178.46                                   
REMARK 500    ARG D3225      122.49    -36.87                                   
REMARK 500    GLN D3229      -61.61    -10.39                                   
REMARK 500    GLN D3230      -49.32    -24.92                                   
REMARK 500    TYR D3231      -70.65    -54.98                                   
REMARK 500    ASP D3256       60.15     11.32                                   
REMARK 500    ASN D3259      -76.55      1.35                                   
REMARK 500    HIS D3260      -73.19    -39.23                                   
REMARK 500    LYS D3268      -85.07    -48.88                                   
REMARK 500    CYS D3274       49.84    -98.22                                   
REMARK 500    ASP D3279       -4.00    -54.68                                   
REMARK 500    ILE D3280      -81.60   -123.34                                   
REMARK 500    ALA D3284      -97.14    -34.71                                   
REMARK 500    ALA D3285      -22.14    -31.28                                   
REMARK 500    LEU D3291      -72.70    -36.03                                   
REMARK 500    LEU D3292      -37.90    -35.51                                   
REMARK 500    SER D3299       60.24     36.73                                   
REMARK 500    PRO D3301       83.04    -27.51                                   
REMARK 500    ILE D3302      -90.48     10.82                                   
REMARK 500    SER D3303      -66.25     -0.09                                   
REMARK 500    HIS D3305      138.00    -26.26                                   
REMARK 500    ALA D3312       41.82   -147.96                                   
REMARK 500    GLU D3314      -69.00     45.83                                   
REMARK 500    ASN D3330       53.04    -94.77                                   
REMARK 500    GLN D3335      -70.87    -57.98                                   
REMARK 500    GLN D3338        9.48    -69.92                                   
REMARK 500    ASP D3345     -153.70   -102.58                                   
REMARK 500    ALA D3369      134.38    -39.49                                   
REMARK 500    GLU D3371      -57.78    -15.32                                   
REMARK 500    VAL D3381      -36.14    -39.76                                   
REMARK 500    LYS D3385       77.09     66.62                                   
REMARK 500    ARG D3397       95.01    -68.93                                   
REMARK 500    ILE D3404      -77.04    -61.77                                   
REMARK 500    ARG D3413       68.76   -151.32                                   
REMARK 500    SER D3420      138.76    -24.92                                   
REMARK 500    PRO D3422     -118.86    -47.38                                   
REMARK 500    CYS D3428     -156.17   -145.02                                   
REMARK 500    ALA D3430        2.73    -67.96                                   
REMARK 500    GLU D3432      -76.93    -55.44                                   
REMARK 500    ALA D3433      -69.30    -15.40                                   
REMARK 500    THR D3437       -9.82   -148.37                                   
REMARK 500    GLU D3438       30.73     70.88                                   
REMARK 500    ALA D3444      112.98   -174.79                                   
REMARK 500    PRO D3451      156.02    -44.33                                   
REMARK 500    ILE D3470      -70.89   -116.74                                   
REMARK 500    VAL D3474      -66.40    -92.93                                   
REMARK 500    ILE D3479      -72.67    -62.28                                   
REMARK 500    LEU D3480      -25.81    -35.18                                   
REMARK 500    ASN D3482       37.63     37.74                                   
REMARK 500    GLN D3520      -79.09    -60.51                                   
REMARK 500    GLU D3545      106.34    -44.48                                   
REMARK 500    ALA D3550      -73.55    -56.96                                   
REMARK 500    TYR D3552      -78.10    -39.68                                   
REMARK 500    LYS D3554       -0.32    -50.69                                   
REMARK 500    TYR D3570      141.22   -172.74                                   
REMARK 500    PRO E4056       83.79    -64.83                                   
REMARK 500    LYS E4057      135.70    178.76                                   
REMARK 500    TYR E4082      -72.04    -52.69                                   
REMARK 500    GLN E4089      -74.11    -73.67                                   
REMARK 500    GLU E4090       22.10    -61.71                                   
REMARK 500    ARG E4091      -40.71   -132.04                                   
REMARK 500    ASN E4092       89.44   -155.58                                   
REMARK 500    LEU E4100      -71.78    -49.80                                   
REMARK 500    ASP E4103       45.71   -149.03                                   
REMARK 500    TYR E4112     -146.70   -111.70                                   
REMARK 500    TYR E4123      145.11    -29.83                                   
REMARK 500    ARG E4128      -47.32   -137.57                                   
REMARK 500    HIS E4142       13.03   -151.64                                   
REMARK 500    LEU E4167     -141.47     28.58                                   
REMARK 500    LEU E4213       -5.39    -46.13                                   
REMARK 500    PRO E4216        8.75    -66.97                                   
REMARK 500    THR E4228     -177.66    -58.54                                   
REMARK 500    GLN E4230      -30.76    -36.40                                   
REMARK 500    ASP E4256       62.32     31.48                                   
REMARK 500    PHE E4257     -141.06    -99.28                                   
REMARK 500    ASN E4259      -73.35     37.63                                   
REMARK 500    LYS E4268      -70.57    -61.37                                   
REMARK 500    TYR E4273     -158.28   -146.63                                   
REMARK 500    CYS E4274       58.99   -117.08                                   
REMARK 500    ALA E4294      -72.85    -57.35                                   
REMARK 500    GLN E4295      -37.41    -36.48                                   
REMARK 500    PRO E4301       85.80    -45.78                                   
REMARK 500    ILE E4302      -55.64      3.38                                   
REMARK 500    HIS E4305      159.41    -39.33                                   
REMARK 500    GLU E4314      -87.33     41.94                                   
REMARK 500    LEU E4332     -174.98    -60.58                                   
REMARK 500    GLU E4334      -40.32    -28.01                                   
REMARK 500    ASP E4345     -170.13    -59.51                                   
REMARK 500    TYR E4347       66.89   -107.17                                   
REMARK 500    ARG E4354      161.98    -39.88                                   
REMARK 500    GLU E4363      -70.68    -35.37                                   
REMARK 500    PRO E4364      -30.49    -37.48                                   
REMARK 500    ALA E4369      116.98    -33.03                                   
REMARK 500    PRO E4370     -165.23    -76.31                                   
REMARK 500    GLU E4371      -81.88    -56.35                                   
REMARK 500    ASP E4379      -75.48    -62.46                                   
REMARK 500    LYS E4385       67.09     82.31                                   
REMARK 500    VAL E4392       80.18   -151.03                                   
REMARK 500    ALA E4393      -12.51   -144.69                                   
REMARK 500    ARG E4397       75.20    -69.00                                   
REMARK 500    ILE E4404      -82.78    -61.55                                   
REMARK 500    SER E4420      136.82    -36.26                                   
REMARK 500    PRO E4422     -127.27    -63.53                                   
REMARK 500    GLU E4431      -73.22    -60.72                                   
REMARK 500    LEU E4436       13.53    -69.95                                   
REMARK 500    THR E4437       11.13   -148.38                                   
REMARK 500    GLU E4438       -0.62     55.10                                   
REMARK 500    THR E4455      -25.44    -38.45                                   
REMARK 500    ILE E4470      -71.21   -112.56                                   
REMARK 500    PHE E4471      -33.42    -35.92                                   
REMARK 500    VAL E4474      -70.46    -87.88                                   
REMARK 500    ASP E4504      -70.24    -47.55                                   
REMARK 500    LEU E4512       30.83    -99.72                                   
REMARK 500    LEU E4516       -8.60    -49.51                                   
REMARK 500    ASN E4518       56.34    -99.91                                   
REMARK 500    GLN E4520      -77.11    -48.75                                   
REMARK 500    LYS E4554       -3.08    -51.62                                   
REMARK 500    THR F5041      174.05    -55.43                                   
REMARK 500    PRO F5056       55.97    -62.71                                   
REMARK 500    TYR F5082      -70.66    -40.68                                   
REMARK 500    ARG F5091      -61.54   -127.89                                   
REMARK 500    GLU F5093      -77.84    -49.45                                   
REMARK 500    LYS F5094      -38.87    -37.80                                   
REMARK 500    TYR F5112     -139.46   -121.89                                   
REMARK 500    ARG F5128      -55.34   -131.84                                   
REMARK 500    SER F5138        4.87    -60.20                                   
REMARK 500    VAL F5143      -42.61    -29.40                                   
REMARK 500    ARG F5165       66.20   -151.15                                   
REMARK 500    ILE F5166       93.48    -68.73                                   
REMARK 500    LEU F5167     -151.04     50.97                                   
REMARK 500    VAL F5174      -16.13    -49.12                                   
REMARK 500    LEU F5199      114.99   -162.87                                   
REMARK 500    ASN F5209       97.34    -68.10                                   
REMARK 500    LEU F5213       12.26    -64.19                                   
REMARK 500    THR F5228     -159.38    -70.35                                   
REMARK 500    ILE F5242      -87.82    -59.01                                   
REMARK 500    ASP F5256       74.40      2.72                                   
REMARK 500    PHE F5257     -160.53   -111.22                                   
REMARK 500    ASN F5259      -63.64    -12.24                                   
REMARK 500    HIS F5260      -72.56    -47.33                                   
REMARK 500    LYS F5268      -78.12    -60.75                                   
REMARK 500    CYS F5274       44.13   -109.33                                   
REMARK 500    ASP F5279       30.02    -65.35                                   
REMARK 500    ILE F5280      -81.53   -144.92                                   
REMARK 500    THR F5283      -82.30    -50.26                                   
REMARK 500    ALA F5284      -58.33    -21.33                                   
REMARK 500    LYS F5296       -2.40    -59.27                                   
REMARK 500    PRO F5301       76.45    -31.19                                   
REMARK 500    ILE F5302     -104.76     24.00                                   
REMARK 500    SER F5303      -42.62      0.68                                   
REMARK 500    GLU F5314      -92.22     28.37                                   
REMARK 500    ALA F5316      -75.98    -47.71                                   
REMARK 500    ALA F5320      -65.95    -28.49                                   
REMARK 500    LEU F5332      169.28    -41.10                                   
REMARK 500    ARG F5354      156.80    -37.96                                   
REMARK 500    ASP F5359      153.26    -49.97                                   
REMARK 500    LYS F5385       71.40     40.99                                   
REMARK 500    ILE F5404      -75.78    -64.77                                   
REMARK 500    PRO F5422     -168.89    -79.49                                   
REMARK 500    THR F5423       -1.43    -53.58                                   
REMARK 500    GLU F5431      -80.85    -65.46                                   
REMARK 500    GLU F5432       -4.25    -46.02                                   
REMARK 500    ALA F5433      -73.64    -91.66                                   
REMARK 500    LEU F5436       26.72    -70.92                                   
REMARK 500    THR F5437       15.62   -161.88                                   
REMARK 500    PRO F5451      165.07    -36.63                                   
REMARK 500    ILE F5470      -80.39   -113.58                                   
REMARK 500    PHE F5471      -39.86    -32.39                                   
REMARK 500    LEU F5498      -79.18    -54.91                                   
REMARK 500    LEU F5502      151.86    -45.02                                   
REMARK 500    PRO F5514      162.80    -48.08                                   
REMARK 500    GLN F5520      -85.59    -65.12                                   
REMARK 500    GLU F5532      -71.82    -49.31                                   
REMARK 500    GLU F5545      107.07    -52.59                                   
REMARK 500    PRO G6056       44.29    -69.32                                   
REMARK 500    GLN G6061      -39.46    -31.73                                   
REMARK 500    ARG G6067      -30.78    -36.63                                   
REMARK 500    ARG G6070        0.91    -67.75                                   
REMARK 500    GLU G6090       43.67    -82.46                                   
REMARK 500    ARG G6091      -41.35   -153.25                                   
REMARK 500    TYR G6112     -138.30   -128.20                                   
REMARK 500    HIS G6125      -26.34   -140.44                                   
REMARK 500    PHE G6127      134.99    -27.54                                   
REMARK 500    ARG G6128      -53.17   -133.25                                   
REMARK 500    ARG G6140      106.83    -38.36                                   
REMARK 500    PRO G6151      -10.79    -45.78                                   
REMARK 500    ASN G6153      -84.85    -74.92                                   
REMARK 500    LEU G6167     -153.43     44.98                                   
REMARK 500    TYR G6187      -38.44    -38.59                                   
REMARK 500    ASN G6209       96.50    -62.37                                   
REMARK 500    LEU G6213       14.76    -64.78                                   
REMARK 500    LYS G6224     -172.76    -61.48                                   
REMARK 500    TYR G6231      -80.75    -42.59                                   
REMARK 500    GLU G6237      -72.64    -62.65                                   
REMARK 500    ASP G6244      -73.89    -72.18                                   
REMARK 500    GLU G6255     -148.72   -152.34                                   
REMARK 500    ASP G6256       67.82    -34.50                                   
REMARK 500    PHE G6257     -153.91   -107.00                                   
REMARK 500    ASN G6259      -81.38     19.81                                   
REMARK 500    ASN G6261      -78.10    -54.83                                   
REMARK 500    LYS G6268      -84.32    -70.79                                   
REMARK 500    TYR G6269        0.78    -69.49                                   
REMARK 500    CYS G6274       66.19   -102.62                                   
REMARK 500    ILE G6280      -46.74   -140.41                                   
REMARK 500    ALA G6284      -76.53    -43.94                                   
REMARK 500    ALA G6285      -50.41    -25.76                                   
REMARK 500    SER G6299       60.86     74.75                                   
REMARK 500    PRO G6301       74.00    -20.26                                   
REMARK 500    ILE G6302      -81.13     27.03                                   
REMARK 500    SER G6303      -71.60     -1.36                                   
REMARK 500    LYS G6306       75.50   -166.91                                   
REMARK 500    ALA G6312       59.20   -145.55                                   
REMARK 500    GLU G6314      -87.89     51.39                                   
REMARK 500    ALA G6337      -70.48    -43.59                                   
REMARK 500    ASP G6345     -167.64    -72.72                                   
REMARK 500    LEU G6350       80.14    -69.40                                   
REMARK 500    GLU G6363      -67.48    -11.86                                   
REMARK 500    PRO G6364       -9.67    -52.34                                   
REMARK 500    PRO G6370     -154.00    -61.23                                   
REMARK 500    LYS G6385       53.45     73.96                                   
REMARK 500    ALA G6393       -7.02    178.25                                   
REMARK 500    ARG G6397      105.22    -58.40                                   
REMARK 500    PHE G6399       78.19   -112.72                                   
REMARK 500    ILE G6404      -71.04    -59.15                                   
REMARK 500    PRO G6422     -131.88    -62.37                                   
REMARK 500    CYS G6428     -155.09   -146.48                                   
REMARK 500    GLU G6431      -75.86    -42.35                                   
REMARK 500    GLU G6432       40.48    -64.03                                   
REMARK 500    ALA G6433      -36.46   -143.63                                   
REMARK 500    GLU G6438       18.01     53.64                                   
REMARK 500    PRO G6451      177.82    -50.36                                   
REMARK 500    LEU G6454      171.00    -58.89                                   
REMARK 500    VAL G6468        5.97    -57.69                                   
REMARK 500    ILE G6470      -92.43   -105.33                                   
REMARK 500    PHE G6471      -49.68    -19.73                                   
REMARK 500    ILE G6479      -86.17    -51.83                                   
REMARK 500    LEU G6480      -31.63    -38.95                                   
REMARK 500    ASN G6482       12.51     54.58                                   
REMARK 500    ASP G6488      -34.67    -32.99                                   
REMARK 500    LYS G6496      -74.32    -49.07                                   
REMARK 500    ALA G6497      -52.84    -22.13                                   
REMARK 500    GLN G6509        5.76    -56.48                                   
REMARK 500    LEU G6512       33.93    -90.12                                   
REMARK 500    GLN G6520      -85.23    -63.76                                   
REMARK 500    ALA G6550      -75.27    -44.82                                   
REMARK 500    TYR G6552      -73.86    -61.25                                   
REMARK 500    TYR G6562      148.69    -26.74                                   
REMARK 500    PRO H7056       84.43    -69.48                                   
REMARK 500    LYS H7057      131.19   -173.02                                   
REMARK 500    SER H7077      150.25    -45.64                                   
REMARK 500    GLU H7090       13.53    -61.06                                   
REMARK 500    ARG H7091      -34.61   -131.14                                   
REMARK 500    ASN H7092       83.40   -159.22                                   
REMARK 500    LYS H7094      -72.07    -64.89                                   
REMARK 500    ASP H7102      -38.06    -37.72                                   
REMARK 500    ASP H7103       28.80   -142.49                                   
REMARK 500    ILE H7104      -46.40    -19.42                                   
REMARK 500    ILE H7110      -65.82    -93.33                                   
REMARK 500    TYR H7112     -152.73   -114.41                                   
REMARK 500    PHE H7127      145.60    -38.31                                   
REMARK 500    ARG H7128      -49.37   -142.12                                   
REMARK 500    LYS H7131      -39.23   -136.49                                   
REMARK 500    ILE H7166       84.23    -67.76                                   
REMARK 500    LEU H7167     -143.61     64.11                                   
REMARK 500    LEU H7172       27.27   -141.68                                   
REMARK 500    ILE H7193      106.20    -58.14                                   
REMARK 500    ARG H7194      122.35    -28.84                                   
REMARK 500    VAL H7205       33.24   -146.77                                   
REMARK 500    LEU H7213        3.27    -65.47                                   
REMARK 500    TYR H7222       88.95    -66.36                                   
REMARK 500    THR H7228     -166.35    -63.25                                   
REMARK 500    GLN H7230      -64.53    -19.55                                   
REMARK 500    TYR H7231      -72.82    -31.62                                   
REMARK 500    ASP H7244      -72.68    -52.59                                   
REMARK 500    ASP H7256       47.54     15.85                                   
REMARK 500    PHE H7257     -149.78    -83.05                                   
REMARK 500    ASN H7259      -88.04     24.51                                   
REMARK 500    HIS H7260      -56.92    -28.43                                   
REMARK 500    PHE H7263      -72.43    -83.29                                   
REMARK 500    TYR H7273     -155.86   -129.64                                   
REMARK 500    CYS H7274       78.95   -106.29                                   
REMARK 500    PHE H7276      133.51   -170.27                                   
REMARK 500    ASP H7279       15.21    -59.83                                   
REMARK 500    ILE H7280      -86.76   -136.99                                   
REMARK 500    ALA H7293      -35.28    -36.00                                   
REMARK 500    PRO H7301       75.95    -33.10                                   
REMARK 500    ILE H7302      -95.59     21.16                                   
REMARK 500    SER H7303      -60.83      8.08                                   
REMARK 500    LYS H7306       94.80   -161.60                                   
REMARK 500    GLU H7314      -88.70      5.00                                   
REMARK 500    ALA H7316      -72.22    -54.87                                   
REMARK 500    ALA H7320      -34.60    -37.52                                   
REMARK 500    GLU H7334      -37.83    -38.21                                   
REMARK 500    ASP H7345     -169.33   -103.97                                   
REMARK 500    TYR H7347       49.28   -108.40                                   
REMARK 500    LEU H7350       81.36    -63.00                                   
REMARK 500    LYS H7352      152.87    -47.82                                   
REMARK 500    GLU H7363      -53.08    -23.99                                   
REMARK 500    HIS H7367     -176.44    -62.31                                   
REMARK 500    VAL H7381      -57.96    -29.76                                   
REMARK 500    ALA H7393        6.08   -157.75                                   
REMARK 500    ARG H7397       93.12    -63.36                                   
REMARK 500    PHE H7399       66.45   -112.47                                   
REMARK 500    SER H7409      -87.18    -65.06                                   
REMARK 500    ILE H7410      -36.27    -16.27                                   
REMARK 500    ARG H7413       75.28   -151.69                                   
REMARK 500    THR H7423        8.22    -47.35                                   
REMARK 500    CYS H7428     -159.80   -163.83                                   
REMARK 500    GLU H7431      -71.18    -53.01                                   
REMARK 500    ALA H7433      -83.06    -80.43                                   
REMARK 500    GLU H7438       15.20     57.21                                   
REMARK 500    PHE H7449      128.88   -172.19                                   
REMARK 500    ASN H7467       -5.91    -57.68                                   
REMARK 500    ILE H7470      -77.35    -81.01                                   
REMARK 500    PHE H7471      -37.00    -37.15                                   
REMARK 500    ALA H7477      -76.42    -63.28                                   
REMARK 500    ASN H7482       15.85     54.09                                   
REMARK 500    LEU H7498      -71.69    -63.68                                   
REMARK 500    SER H7500       26.17    -69.30                                   
REMARK 500    ALA H7508      -71.95    -56.00                                   
REMARK 500    GLN H7520      -79.78    -69.58                                   
REMARK 500    GLU H7532      -75.78    -27.50                                   
REMARK 500    ARG H7542      156.37    -47.87                                   
REMARK 500    GLU H7547      -65.15    -96.79                                   
REMARK 500    VAL H7553      -71.91    -51.75                                   
REMARK 500    LYS H7554      -13.69    -39.29                                   
REMARK 500    ARG H7556       54.22   -103.83                                   
REMARK 500    ASP H7568       96.00    -64.60                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    TYR A 187         0.07    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 615                                                                      
REMARK 615 ZERO OCCUPANCY ATOM                                                  
REMARK 615 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO                  
REMARK 615 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS                
REMARK 615 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;              
REMARK 615 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):         
REMARK 615   M RES C SSEQI                                                      
REMARK 615     NAD A  602                                                       
REMARK 615     NAD B 1602                                                       
REMARK 615     NAD C 2602                                                       
REMARK 615     NAD D 3602                                                       
REMARK 615     NAD E 4602                                                       
REMARK 615     NAD F 5602                                                       
REMARK 615     NAD G 6602                                                       
REMARK 615     NAD H 7602                                                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU A 604                  
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU B 1604                 
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU C 2604                 
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU D 3604                 
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU E 4604                 
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU F 5604                 
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU G 6604                 
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE LU H 7604                 
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD A 601                 
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD A 602                 
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD B 1601                
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD B 1602                
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD C 2601                
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD C 2602                
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD D 3601                
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD D 3602                
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD E 4601                
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD E 4602                
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD F 5601                
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD F 5602                
REMARK 800 SITE_IDENTIFIER: CC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD G 6601                
REMARK 800 SITE_IDENTIFIER: CC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD G 6602                
REMARK 800 SITE_IDENTIFIER: CC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD H 7601                
REMARK 800 SITE_IDENTIFIER: CC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAD H 7602                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1DO8   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 1QR6   RELATED DB: PDB                                   
DBREF  1PJL A    1   584  UNP    P23368   MAOM_HUMAN       1    584             
DBREF  1PJL B 1001  1584  UNP    P23368   MAOM_HUMAN       1    584             
DBREF  1PJL C 2001  2584  UNP    P23368   MAOM_HUMAN       1    584             
DBREF  1PJL D 3001  3584  UNP    P23368   MAOM_HUMAN       1    584             
DBREF  1PJL E 4001  4584  UNP    P23368   MAOM_HUMAN       1    584             
DBREF  1PJL F 5001  5584  UNP    P23368   MAOM_HUMAN       1    584             
DBREF  1PJL G 6001  6584  UNP    P23368   MAOM_HUMAN       1    584             
DBREF  1PJL H 7001  7584  UNP    P23368   MAOM_HUMAN       1    584             
SEQADV 1PJL MSE A    1  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE A   29  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE A   38  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE A   47  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE A   75  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE A   86  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE A  539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1001  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1029  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1038  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1047  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1075  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1086  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE B 1539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2001  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2029  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2038  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2047  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2075  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2086  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE C 2539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3001  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3029  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3038  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3047  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3075  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3086  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE D 3539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4001  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4029  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4038  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4047  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4075  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4086  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE E 4539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5001  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5029  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5038  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5047  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5075  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5086  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE F 5539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6001  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6029  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6038  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6047  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6075  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6086  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE G 6539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7001  UNP  P23368    MET     1 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7029  UNP  P23368    MET    29 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7038  UNP  P23368    MET    38 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7047  UNP  P23368    MET    47 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7075  UNP  P23368    MET    75 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7086  UNP  P23368    MET    86 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7108  UNP  P23368    MET   108 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7177  UNP  P23368    MET   177 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7219  UNP  P23368    MET   219 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7239  UNP  P23368    MET   239 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7325  UNP  P23368    MET   325 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7327  UNP  P23368    MET   327 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7343  UNP  P23368    MET   343 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7407  UNP  P23368    MET   407 MODIFIED RESIDUE               
SEQADV 1PJL MSE H 7539  UNP  P23368    MET   539 MODIFIED RESIDUE               
SEQRES   1 A  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 A  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 A  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 A  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 A  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 A  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 A  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 A  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 A  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 A  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 A  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 A  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 A  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 A  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 A  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 A  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 A  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 A  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 A  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 A  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 A  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 A  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 A  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 A  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 A  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 A  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 A  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 A  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 A  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 A  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 A  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 A  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 A  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 A  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 A  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 A  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 A  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 A  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 A  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 A  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 A  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 A  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 A  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 A  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 A  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
SEQRES   1 B  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 B  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 B  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 B  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 B  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 B  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 B  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 B  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 B  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 B  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 B  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 B  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 B  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 B  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 B  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 B  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 B  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 B  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 B  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 B  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 B  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 B  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 B  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 B  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 B  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 B  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 B  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 B  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 B  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 B  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 B  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 B  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 B  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 B  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 B  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 B  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 B  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 B  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 B  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 B  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 B  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 B  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 B  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 B  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 B  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
SEQRES   1 C  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 C  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 C  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 C  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 C  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 C  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 C  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 C  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 C  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 C  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 C  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 C  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 C  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 C  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 C  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 C  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 C  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 C  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 C  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 C  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 C  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 C  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 C  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 C  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 C  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 C  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 C  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 C  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 C  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 C  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 C  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 C  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 C  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 C  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 C  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 C  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 C  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 C  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 C  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 C  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 C  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 C  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 C  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 C  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 C  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
SEQRES   1 D  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 D  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 D  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 D  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 D  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 D  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 D  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 D  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 D  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 D  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 D  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 D  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 D  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 D  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 D  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 D  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 D  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 D  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 D  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 D  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 D  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 D  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 D  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 D  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 D  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 D  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 D  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 D  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 D  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 D  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 D  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 D  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 D  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 D  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 D  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 D  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 D  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 D  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 D  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 D  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 D  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 D  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 D  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 D  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 D  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
SEQRES   1 E  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 E  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 E  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 E  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 E  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 E  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 E  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 E  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 E  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 E  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 E  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 E  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 E  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 E  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 E  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 E  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 E  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 E  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 E  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 E  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 E  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 E  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 E  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 E  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 E  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 E  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 E  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 E  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 E  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 E  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 E  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 E  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 E  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 E  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 E  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 E  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 E  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 E  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 E  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 E  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 E  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 E  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 E  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 E  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 E  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
SEQRES   1 F  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 F  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 F  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 F  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 F  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 F  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 F  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 F  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 F  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 F  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 F  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 F  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 F  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 F  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 F  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 F  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 F  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 F  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 F  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 F  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 F  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 F  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 F  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 F  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 F  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 F  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 F  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 F  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 F  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 F  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 F  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 F  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 F  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 F  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 F  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 F  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 F  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 F  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 F  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 F  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 F  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 F  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 F  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 F  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 F  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
SEQRES   1 G  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 G  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 G  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 G  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 G  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 G  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 G  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 G  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 G  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 G  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 G  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 G  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 G  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 G  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 G  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 G  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 G  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 G  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 G  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 G  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 G  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 G  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 G  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 G  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 G  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 G  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 G  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 G  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 G  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 G  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 G  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 G  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 G  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 G  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 G  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 G  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 G  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 G  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 G  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 G  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 G  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 G  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 G  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 G  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 G  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
SEQRES   1 H  584  MSE LEU SER ARG LEU ARG VAL VAL SER THR THR CYS THR          
SEQRES   2 H  584  LEU ALA CYS ARG HIS LEU HIS ILE LYS GLU LYS GLY LYS          
SEQRES   3 H  584  PRO LEU MSE LEU ASN PRO ARG THR ASN LYS GLY MSE ALA          
SEQRES   4 H  584  PHE THR LEU GLN GLU ARG GLN MSE LEU GLY LEU GLN GLY          
SEQRES   5 H  584  LEU LEU PRO PRO LYS ILE GLU THR GLN ASP ILE GLN ALA          
SEQRES   6 H  584  LEU ARG PHE HIS ARG ASN LEU LYS LYS MSE THR SER PRO          
SEQRES   7 H  584  LEU GLU LYS TYR ILE TYR ILE MSE GLY ILE GLN GLU ARG          
SEQRES   8 H  584  ASN GLU LYS LEU PHE TYR ARG ILE LEU GLN ASP ASP ILE          
SEQRES   9 H  584  GLU SER LEU MSE PRO ILE VAL TYR THR PRO THR VAL GLY          
SEQRES  10 H  584  LEU ALA CYS SER GLN TYR GLY HIS ILE PHE ARG ARG PRO          
SEQRES  11 H  584  LYS GLY LEU PHE ILE SER ILE SER ASP ARG GLY HIS VAL          
SEQRES  12 H  584  ARG SER ILE VAL ASP ASN TRP PRO GLU ASN HIS VAL LYS          
SEQRES  13 H  584  ALA VAL VAL VAL THR ASP GLY GLU ARG ILE LEU GLY LEU          
SEQRES  14 H  584  GLY ASP LEU GLY VAL TYR GLY MSE GLY ILE PRO VAL GLY          
SEQRES  15 H  584  LYS LEU CYS LEU TYR THR ALA CYS ALA GLY ILE ARG PRO          
SEQRES  16 H  584  ASP ARG CYS LEU PRO VAL CYS ILE ASP VAL GLY THR ASP          
SEQRES  17 H  584  ASN ILE ALA LEU LEU LYS ASP PRO PHE TYR MSE GLY LEU          
SEQRES  18 H  584  TYR GLN LYS ARG ASP ARG THR GLN GLN TYR ASP ASP LEU          
SEQRES  19 H  584  ILE ASP GLU PHE MSE LYS ALA ILE THR ASP ARG TYR GLY          
SEQRES  20 H  584  ARG ASN THR LEU ILE GLN PHE GLU ASP PHE GLY ASN HIS          
SEQRES  21 H  584  ASN ALA PHE ARG PHE LEU ARG LYS TYR ARG GLU LYS TYR          
SEQRES  22 H  584  CYS THR PHE ASN ASP ASP ILE GLN GLY THR ALA ALA VAL          
SEQRES  23 H  584  ALA LEU ALA GLY LEU LEU ALA ALA GLN LYS VAL ILE SER          
SEQRES  24 H  584  LYS PRO ILE SER GLU HIS LYS ILE LEU PHE LEU GLY ALA          
SEQRES  25 H  584  GLY GLU ALA ALA LEU GLY ILE ALA ASN LEU ILE VAL MSE          
SEQRES  26 H  584  SER MSE VAL GLU ASN GLY LEU SER GLU GLN GLU ALA GLN          
SEQRES  27 H  584  LYS LYS ILE TRP MSE PHE ASP LYS TYR GLY LEU LEU VAL          
SEQRES  28 H  584  LYS GLY ARG LYS ALA LYS ILE ASP SER TYR GLN GLU PRO          
SEQRES  29 H  584  PHE THR HIS SER ALA PRO GLU SER ILE PRO ASP THR PHE          
SEQRES  30 H  584  GLU ASP ALA VAL ASN ILE LEU LYS PRO SER THR ILE ILE          
SEQRES  31 H  584  GLY VAL ALA GLY ALA GLY ARG LEU PHE THR PRO ASP VAL          
SEQRES  32 H  584  ILE ARG ALA MSE ALA SER ILE ASN GLU ARG PRO VAL ILE          
SEQRES  33 H  584  PHE ALA LEU SER ASN PRO THR ALA GLN ALA GLU CYS THR          
SEQRES  34 H  584  ALA GLU GLU ALA TYR THR LEU THR GLU GLY ARG CYS LEU          
SEQRES  35 H  584  PHE ALA SER GLY SER PRO PHE GLY PRO VAL LYS LEU THR          
SEQRES  36 H  584  ASP GLY ARG VAL PHE THR PRO GLY GLN GLY ASN ASN VAL          
SEQRES  37 H  584  TYR ILE PHE PRO GLY VAL ALA LEU ALA VAL ILE LEU CYS          
SEQRES  38 H  584  ASN THR ARG HIS ILE SER ASP SER VAL PHE LEU GLU ALA          
SEQRES  39 H  584  ALA LYS ALA LEU THR SER GLN LEU THR ASP GLU GLU LEU          
SEQRES  40 H  584  ALA GLN GLY ARG LEU TYR PRO PRO LEU ALA ASN ILE GLN          
SEQRES  41 H  584  GLU VAL SER ILE ASN ILE ALA ILE LYS VAL THR GLU TYR          
SEQRES  42 H  584  LEU TYR ALA ASN LYS MSE ALA PHE ARG TYR PRO GLU PRO          
SEQRES  43 H  584  GLU ASP LYS ALA LYS TYR VAL LYS GLU ARG THR TRP ARG          
SEQRES  44 H  584  SER GLU TYR ASP SER LEU LEU PRO ASP VAL TYR GLU TRP          
SEQRES  45 H  584  PRO GLU SER ALA SER SER PRO PRO VAL ILE THR GLU              
MODRES 1PJL MSE A   29  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A   38  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A   47  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A   75  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A   86  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE A  539  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1029  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1038  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1047  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1075  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1086  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE B 1539  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2029  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2038  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2047  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2075  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2086  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE C 2539  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3029  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3038  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3047  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3075  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3086  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE D 3539  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4029  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4038  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4047  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4075  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4086  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE E 4539  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5029  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5038  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5047  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5075  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5086  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE F 5539  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6029  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6038  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6047  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6075  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6086  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE G 6539  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7029  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7038  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7047  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7075  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7086  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7108  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7177  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7219  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7239  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7325  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7327  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7343  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7407  MET  SELENOMETHIONINE                                   
MODRES 1PJL MSE H 7539  MET  SELENOMETHIONINE                                   
HET    MSE  A  29       8                                                       
HET    MSE  A  38       8                                                       
HET    MSE  A  47       8                                                       
HET    MSE  A  75       8                                                       
HET    MSE  A  86       8                                                       
HET    MSE  A 108       8                                                       
HET    MSE  A 177       8                                                       
HET    MSE  A 219       8                                                       
HET    MSE  A 239       8                                                       
HET    MSE  A 325       8                                                       
HET    MSE  A 327       8                                                       
HET    MSE  A 343       8                                                       
HET    MSE  A 407       8                                                       
HET    MSE  A 539       8                                                       
HET    MSE  B1029       8                                                       
HET    MSE  B1038       8                                                       
HET    MSE  B1047       8                                                       
HET    MSE  B1075       8                                                       
HET    MSE  B1086       8                                                       
HET    MSE  B1108       8                                                       
HET    MSE  B1177       8                                                       
HET    MSE  B1219       8                                                       
HET    MSE  B1239       8                                                       
HET    MSE  B1325       8                                                       
HET    MSE  B1327       8                                                       
HET    MSE  B1343       8                                                       
HET    MSE  B1407       8                                                       
HET    MSE  B1539       8                                                       
HET    MSE  C2029       8                                                       
HET    MSE  C2038       8                                                       
HET    MSE  C2047       8                                                       
HET    MSE  C2075       8                                                       
HET    MSE  C2086       8                                                       
HET    MSE  C2108       8                                                       
HET    MSE  C2177       8                                                       
HET    MSE  C2219       8                                                       
HET    MSE  C2239       8                                                       
HET    MSE  C2325       8                                                       
HET    MSE  C2327       8                                                       
HET    MSE  C2343       8                                                       
HET    MSE  C2407       8                                                       
HET    MSE  C2539       8                                                       
HET    MSE  D3029       8                                                       
HET    MSE  D3038       8                                                       
HET    MSE  D3047       8                                                       
HET    MSE  D3075       8                                                       
HET    MSE  D3086       8                                                       
HET    MSE  D3108       8                                                       
HET    MSE  D3177       8                                                       
HET    MSE  D3219       8                                                       
HET    MSE  D3239       8                                                       
HET    MSE  D3325       8                                                       
HET    MSE  D3327       8                                                       
HET    MSE  D3343       8                                                       
HET    MSE  D3407       8                                                       
HET    MSE  D3539       8                                                       
HET    MSE  E4029       8                                                       
HET    MSE  E4038       8                                                       
HET    MSE  E4047       8                                                       
HET    MSE  E4075       8                                                       
HET    MSE  E4086       8                                                       
HET    MSE  E4108       8                                                       
HET    MSE  E4177       8                                                       
HET    MSE  E4219       8                                                       
HET    MSE  E4239       8                                                       
HET    MSE  E4325       8                                                       
HET    MSE  E4327       8                                                       
HET    MSE  E4343       8                                                       
HET    MSE  E4407       8                                                       
HET    MSE  E4539       8                                                       
HET    MSE  F5029       8                                                       
HET    MSE  F5038       8                                                       
HET    MSE  F5047       8                                                       
HET    MSE  F5075       8                                                       
HET    MSE  F5086       8                                                       
HET    MSE  F5108       8                                                       
HET    MSE  F5177       8                                                       
HET    MSE  F5219       8                                                       
HET    MSE  F5239       8                                                       
HET    MSE  F5325       8                                                       
HET    MSE  F5327       8                                                       
HET    MSE  F5343       8                                                       
HET    MSE  F5407       8                                                       
HET    MSE  F5539       8                                                       
HET    MSE  G6029       8                                                       
HET    MSE  G6038       8                                                       
HET    MSE  G6047       8                                                       
HET    MSE  G6075       8                                                       
HET    MSE  G6086       8                                                       
HET    MSE  G6108       8                                                       
HET    MSE  G6177       8                                                       
HET    MSE  G6219       8                                                       
HET    MSE  G6239       8                                                       
HET    MSE  G6325       8                                                       
HET    MSE  G6327       8                                                       
HET    MSE  G6343       8                                                       
HET    MSE  G6407       8                                                       
HET    MSE  G6539       8                                                       
HET    MSE  H7029       8                                                       
HET    MSE  H7038       8                                                       
HET    MSE  H7047       8                                                       
HET    MSE  H7075       8                                                       
HET    MSE  H7086       8                                                       
HET    MSE  H7108       8                                                       
HET    MSE  H7177       8                                                       
HET    MSE  H7219       8                                                       
HET    MSE  H7239       8                                                       
HET    MSE  H7325       8                                                       
HET    MSE  H7327       8                                                       
HET    MSE  H7343       8                                                       
HET    MSE  H7407       8                                                       
HET    MSE  H7539       8                                                       
HET     LU  A 604       1                                                       
HET     LU  B1604       1                                                       
HET     LU  C2604       1                                                       
HET     LU  D3604       1                                                       
HET     LU  E4604       1                                                       
HET     LU  F5604       1                                                       
HET     LU  G6604       1                                                       
HET     LU  H7604       1                                                       
HET    NAD  A 601      44                                                       
HET    NAD  A 602      44                                                       
HET    NAD  B1601      44                                                       
HET    NAD  B1602      44                                                       
HET    NAD  C2601      44                                                       
HET    NAD  C2602      44                                                       
HET    NAD  D3601      44                                                       
HET    NAD  D3602      44                                                       
HET    NAD  E4601      44                                                       
HET    NAD  E4602      44                                                       
HET    NAD  F5601      44                                                       
HET    NAD  F5602      44                                                       
HET    NAD  G6601      44                                                       
HET    NAD  G6602      44                                                       
HET    NAD  H7601      44                                                       
HET    NAD  H7602      44                                                       
HETNAM     MSE SELENOMETHIONINE                                                 
HETNAM      LU LUTETIUM (III) ION                                               
HETNAM     NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE                                
HETSYN      LU LU                                                               
FORMUL   1  MSE    112(C5 H11 N O2 SE)                                          
FORMUL   9   LU    8(LU 3+)                                                     
FORMUL  17  NAD    16(C21 H27 N7 O14 P2)                                        
FORMUL  33  HOH   *63(H2 O)                                                     
HELIX    1   1 GLY A   25  ASN A   31  1                                   7    
HELIX    2   2 LYS A   36  PHE A   40  5                                   5    
HELIX    3   3 THR A   41  GLY A   49  1                                   9    
HELIX    4   4 THR A   60  LYS A   74  1                                  15    
HELIX    5   5 SER A   77  GLU A   90  1                                  14    
HELIX    6   6 ASN A   92  TYR A  112  1                                  21    
HELIX    7   7 PRO A  114  TYR A  123  1                                  10    
HELIX    8   8 SER A  138  ARG A  140  5                                   3    
HELIX    9   9 HIS A  142  ASP A  148  1                                   7    
HELIX   10  10 ILE A  166  GLY A  170  5                                   5    
HELIX   11  11 LEU A  172  GLY A  176  5                                   5    
HELIX   12  12 MSE A  177  CYS A  190  1                                  14    
HELIX   13  13 ARG A  194  ASP A  196  5                                   3    
HELIX   14  14 ASN A  209  ASP A  215  1                                   7    
HELIX   15  15 THR A  228  GLY A  247  1                                  20    
HELIX   16  16 GLY A  258  ARG A  270  1                                  13    
HELIX   17  17 ILE A  280  SER A  299  1                                  20    
HELIX   18  18 PRO A  301  HIS A  305  5                                   5    
HELIX   19  19 GLU A  314  ASN A  330  1                                  17    
HELIX   20  20 SER A  333  LYS A  339  1                                   7    
HELIX   21  21 GLN A  362  THR A  366  5                                   5    
HELIX   22  22 THR A  376  LYS A  385  1                                  10    
HELIX   23  23 THR A  400  ASN A  411  1                                  12    
HELIX   24  24 THR A  429  THR A  435  1                                   7    
HELIX   25  25 LEU A  436  GLU A  438  5                                   3    
HELIX   26  26 ASN A  466  TYR A  469  5                                   4    
HELIX   27  27 ILE A  470  CYS A  481  1                                  12    
HELIX   28  28 SER A  487  SER A  500  1                                  14    
HELIX   29  29 THR A  503  GLY A  510  1                                   8    
HELIX   30  30 PRO A  515  ALA A  517  5                                   3    
HELIX   31  31 ASN A  518  ASN A  537  1                                  20    
HELIX   32  32 ASP A  548  ARG A  556  1                                   9    
HELIX   33  33 GLY B 1025  ASN B 1031  1                                   7    
HELIX   34  34 LYS B 1036  PHE B 1040  5                                   5    
HELIX   35  35 THR B 1041  LEU B 1048  1                                   8    
HELIX   36  36 THR B 1060  LYS B 1074  1                                  15    
HELIX   37  37 SER B 1077  GLU B 1090  1                                  14    
HELIX   38  38 ASN B 1092  ASP B 1103  1                                  12    
HELIX   39  39 ASP B 1103  TYR B 1112  1                                  10    
HELIX   40  40 THR B 1115  TYR B 1123  1                                   9    
HELIX   41  41 SER B 1136  ARG B 1140  5                                   5    
HELIX   42  42 HIS B 1142  ASP B 1148  1                                   7    
HELIX   43  43 ILE B 1166  GLY B 1170  5                                   5    
HELIX   44  44 LEU B 1172  GLY B 1176  5                                   5    
HELIX   45  45 MSE B 1177  GLY B 1192  1                                  16    
HELIX   46  46 ARG B 1194  ASP B 1196  5                                   3    
HELIX   47  47 ASN B 1209  LYS B 1214  1                                   6    
HELIX   48  48 GLN B 1229  GLY B 1247  1                                  19    
HELIX   49  49 ASN B 1259  GLU B 1271  1                                  13    
HELIX   50  50 ILE B 1280  VAL B 1297  1                                  18    
HELIX   51  51 PRO B 1301  HIS B 1305  5                                   5    
HELIX   52  52 GLU B 1314  ASN B 1330  1                                  17    
HELIX   53  53 SER B 1333  LYS B 1340  1                                   8    
HELIX   54  54 GLN B 1362  THR B 1366  5                                   5    
HELIX   55  55 THR B 1376  LYS B 1385  1                                  10    
HELIX   56  56 THR B 1400  ASN B 1411  1                                  12    
HELIX   57  57 THR B 1429  THR B 1435  1                                   7    
HELIX   58  58 LEU B 1436  GLU B 1438  5                                   3    
HELIX   59  59 ASN B 1466  TYR B 1469  5                                   4    
HELIX   60  60 ILE B 1470  CYS B 1481  1                                  12    
HELIX   61  61 SER B 1487  SER B 1500  1                                  14    
HELIX   62  62 THR B 1503  GLY B 1510  1                                   8    
HELIX   63  63 PRO B 1515  ALA B 1517  5                                   3    
HELIX   64  64 ASN B 1518  ASN B 1537  1                                  20    
HELIX   65  65 ASP B 1548  ARG B 1556  1                                   9    
HELIX   66  66 GLY C 2025  ASN C 2031  1                                   7    
HELIX   67  67 LYS C 2036  PHE C 2040  5                                   5    
HELIX   68  68 THR C 2041  LEU C 2048  1                                   8    
HELIX   69  69 THR C 2060  LYS C 2073  1                                  14    
HELIX   70  70 SER C 2077  MSE C 2086  1                                  10    
HELIX   71  71 ASN C 2092  ASP C 2103  1                                  12    
HELIX   72  72 ASP C 2103  TYR C 2112  1                                  10    
HELIX   73  73 PRO C 2114  TYR C 2123  1                                  10    
HELIX   74  74 SER C 2138  ARG C 2140  5                                   3    
HELIX   75  75 HIS C 2142  ASP C 2148  1                                   7    
HELIX   76  76 ILE C 2166  GLY C 2170  5                                   5    
HELIX   77  77 LEU C 2172  GLY C 2176  5                                   5    
HELIX   78  78 MSE C 2177  GLY C 2192  1                                  16    
HELIX   79  79 ASN C 2209  LYS C 2214  1                                   6    
HELIX   80  80 THR C 2228  GLY C 2247  1                                  20    
HELIX   81  81 ASN C 2259  GLU C 2271  1                                  13    
HELIX   82  82 ILE C 2280  SER C 2299  1                                  20    
HELIX   83  83 PRO C 2301  HIS C 2305  5                                   5    
HELIX   84  84 GLU C 2314  GLU C 2329  1                                  16    
HELIX   85  85 SER C 2333  LYS C 2339  1                                   7    
HELIX   86  86 GLN C 2362  THR C 2366  5                                   5    
HELIX   87  87 THR C 2376  LYS C 2385  1                                  10    
HELIX   88  88 THR C 2400  ASN C 2411  1                                  12    
HELIX   89  89 THR C 2429  LEU C 2436  1                                   8    
HELIX   90  90 ASN C 2466  TYR C 2469  5                                   4    
HELIX   91  91 ILE C 2470  CYS C 2481  1                                  12    
HELIX   92  92 SER C 2487  SER C 2500  1                                  14    
HELIX   93  93 THR C 2503  GLY C 2510  1                                   8    
HELIX   94  94 PRO C 2515  ALA C 2517  5                                   3    
HELIX   95  95 ASN C 2518  ASN C 2537  1                                  20    
HELIX   96  96 ASP C 2548  THR C 2557  1                                  10    
HELIX   97  97 GLY D 3025  ASN D 3031  1                                   7    
HELIX   98  98 LYS D 3036  PHE D 3040  5                                   5    
HELIX   99  99 THR D 3041  LEU D 3048  1                                   8    
HELIX  100 100 THR D 3060  LYS D 3074  1                                  15    
HELIX  101 101 SER D 3077  GLU D 3090  1                                  14    
HELIX  102 102 ASN D 3092  GLN D 3101  1                                  10    
HELIX  103 103 ASP D 3103  TYR D 3112  1                                  10    
HELIX  104 104 PRO D 3114  TYR D 3123  1                                  10    
HELIX  105 105 SER D 3136  ARG D 3140  5                                   5    
HELIX  106 106 HIS D 3142  ASN D 3149  1                                   8    
HELIX  107 107 ILE D 3166  GLY D 3170  5                                   5    
HELIX  108 108 LEU D 3172  GLY D 3176  5                                   5    
HELIX  109 109 MSE D 3177  GLY D 3192  1                                  16    
HELIX  110 110 ARG D 3194  ASP D 3196  5                                   3    
HELIX  111 111 ASN D 3209  LYS D 3214  1                                   6    
HELIX  112 112 GLN D 3229  GLY D 3247  1                                  19    
HELIX  113 113 GLY D 3258  GLU D 3271  1                                  14    
HELIX  114 114 ASP D 3278  SER D 3299  1                                  22    
HELIX  115 115 PRO D 3301  HIS D 3305  5                                   5    
HELIX  116 116 GLU D 3314  VAL D 3328  1                                  15    
HELIX  117 117 SER D 3333  GLN D 3338  1                                   6    
HELIX  118 118 GLN D 3362  THR D 3366  5                                   5    
HELIX  119 119 THR D 3376  LYS D 3385  1                                  10    
HELIX  120 120 THR D 3400  ASN D 3411  1                                  12    
HELIX  121 121 GLU D 3431  LEU D 3436  1                                   6    
HELIX  122 122 ASN D 3466  TYR D 3469  5                                   4    
HELIX  123 123 ILE D 3470  CYS D 3481  1                                  12    
HELIX  124 124 SER D 3487  SER D 3500  1                                  14    
HELIX  125 125 THR D 3503  GLY D 3510  1                                   8    
HELIX  126 126 PRO D 3515  ALA D 3517  5                                   3    
HELIX  127 127 ASN D 3518  ASN D 3537  1                                  20    
HELIX  128 128 ASP D 3548  THR D 3557  1                                  10    
HELIX  129 129 LYS E 4026  ASN E 4031  1                                   6    
HELIX  130 130 LYS E 4036  PHE E 4040  5                                   5    
HELIX  131 131 THR E 4041  LEU E 4048  1                                   8    
HELIX  132 132 THR E 4060  MSE E 4075  1                                  16    
HELIX  133 133 SER E 4077  GLU E 4090  1                                  14    
HELIX  134 134 ASN E 4092  ASP E 4103  1                                  12    
HELIX  135 135 ASP E 4103  TYR E 4112  1                                  10    
HELIX  136 136 PRO E 4114  TYR E 4123  1                                  10    
HELIX  137 137 HIS E 4142  ASN E 4149  1                                   8    
HELIX  138 138 ILE E 4166  GLY E 4170  5                                   5    
HELIX  139 139 LEU E 4172  GLY E 4176  5                                   5    
HELIX  140 140 MSE E 4177  GLY E 4192  1                                  16    
HELIX  141 141 ARG E 4194  ASP E 4196  5                                   3    
HELIX  142 142 ASN E 4209  LYS E 4214  1                                   6    
HELIX  143 143 THR E 4228  GLY E 4247  1                                  20    
HELIX  144 144 ASN E 4259  ARG E 4270  1                                  12    
HELIX  145 145 ASP E 4278  SER E 4299  1                                  22    
HELIX  146 146 PRO E 4301  HIS E 4305  5                                   5    
HELIX  147 147 GLU E 4314  ASN E 4330  1                                  17    
HELIX  148 148 SER E 4333  GLN E 4338  1                                   6    
HELIX  149 149 GLN E 4362  THR E 4366  5                                   5    
HELIX  150 150 THR E 4376  LYS E 4385  1                                  10    
HELIX  151 151 THR E 4400  ASN E 4411  1                                  12    
HELIX  152 152 THR E 4429  LEU E 4436  1                                   8    
HELIX  153 153 ASN E 4466  TYR E 4469  5                                   4    
HELIX  154 154 ILE E 4470  CYS E 4481  1                                  12    
HELIX  155 155 SER E 4487  SER E 4500  1                                  14    
HELIX  156 156 THR E 4503  ALA E 4508  1                                   6    
HELIX  157 157 PRO E 4515  ALA E 4517  5                                   3    
HELIX  158 158 ASN E 4518  ASN E 4537  1                                  20    
HELIX  159 159 ASP E 4548  LYS E 4554  1                                   7    
HELIX  160 160 GLY F 5025  ASN F 5031  1                                   7    
HELIX  161 161 LYS F 5036  PHE F 5040  5                                   5    
HELIX  162 162 THR F 5041  LEU F 5048  1                                   8    
HELIX  163 163 THR F 5060  LYS F 5073  1                                  14    
HELIX  164 164 SER F 5077  GLU F 5090  1                                  14    
HELIX  165 165 ASN F 5092  ASP F 5103  1                                  12    
HELIX  166 166 ASP F 5103  TYR F 5112  1                                  10    
HELIX  167 167 PRO F 5114  GLN F 5122  1                                   9    
HELIX  168 168 SER F 5138  ARG F 5140  5                                   3    
HELIX  169 169 HIS F 5142  TRP F 5150  1                                   9    
HELIX  170 170 ILE F 5166  GLY F 5170  5                                   5    
HELIX  171 171 LEU F 5172  GLY F 5176  5                                   5    
HELIX  172 172 MSE F 5177  GLY F 5192  1                                  16    
HELIX  173 173 ARG F 5194  ASP F 5196  5                                   3    
HELIX  174 174 ALA F 5211  ASP F 5215  5                                   5    
HELIX  175 175 THR F 5228  GLY F 5247  1                                  20    
HELIX  176 176 GLY F 5258  ARG F 5270  1                                  13    
HELIX  177 177 ILE F 5280  SER F 5299  1                                  20    
HELIX  178 178 PRO F 5301  HIS F 5305  5                                   5    
HELIX  179 179 GLU F 5314  ASN F 5330  1                                  17    
HELIX  180 180 SER F 5333  LYS F 5339  1                                   7    
HELIX  181 181 ASP F 5359  THR F 5366  5                                   8    
HELIX  182 182 THR F 5376  LYS F 5385  1                                  10    
HELIX  183 183 THR F 5400  ASN F 5411  1                                  12    
HELIX  184 184 THR F 5429  THR F 5435  1                                   7    
HELIX  185 185 LEU F 5436  GLU F 5438  5                                   3    
HELIX  186 186 ASN F 5466  TYR F 5469  5                                   4    
HELIX  187 187 ILE F 5470  CYS F 5481  1                                  12    
HELIX  188 188 SER F 5487  SER F 5500  1                                  14    
HELIX  189 189 THR F 5503  GLY F 5510  1                                   8    
HELIX  190 190 PRO F 5515  ALA F 5517  5                                   3    
HELIX  191 191 ASN F 5518  ASN F 5537  1                                  20    
HELIX  192 192 ASP F 5548  ARG F 5556  1                                   9    
HELIX  193 193 GLY G 6025  ASN G 6031  1                                   7    
HELIX  194 194 LYS G 6036  PHE G 6040  5                                   5    
HELIX  195 195 THR G 6041  LEU G 6048  1                                   8    
HELIX  196 196 THR G 6060  LYS G 6073  1                                  14    
HELIX  197 197 SER G 6077  GLU G 6090  1                                  14    
HELIX  198 198 ASN G 6092  ASP G 6103  1                                  12    
HELIX  199 199 ASP G 6103  TYR G 6112  1                                  10    
HELIX  200 200 PRO G 6114  GLN G 6122  1                                   9    
HELIX  201 201 SER G 6138  ARG G 6140  5                                   3    
HELIX  202 202 HIS G 6142  ASP G 6148  1                                   7    
HELIX  203 203 ILE G 6166  GLY G 6170  5                                   5    
HELIX  204 204 LEU G 6172  GLY G 6176  5                                   5    
HELIX  205 205 MSE G 6177  CYS G 6190  1                                  14    
HELIX  206 206 ARG G 6194  ASP G 6196  5                                   3    
HELIX  207 207 ALA G 6211  ASP G 6215  5                                   5    
HELIX  208 208 GLN G 6229  GLY G 6247  1                                  19    
HELIX  209 209 ASN G 6259  ARG G 6270  1                                  12    
HELIX  210 210 ILE G 6280  SER G 6299  1                                  20    
HELIX  211 211 PRO G 6301  HIS G 6305  5                                   5    
HELIX  212 212 GLU G 6314  GLY G 6331  1                                  18    
HELIX  213 213 SER G 6333  LYS G 6340  1                                   8    
HELIX  214 214 GLN G 6362  THR G 6366  5                                   5    
HELIX  215 215 THR G 6376  LYS G 6385  1                                  10    
HELIX  216 216 THR G 6400  ASN G 6411  1                                  12    
HELIX  217 217 ALA G 6430  THR G 6435  1                                   6    
HELIX  218 218 ASN G 6466  TYR G 6469  5                                   4    
HELIX  219 219 ILE G 6470  CYS G 6481  1                                  12    
HELIX  220 220 SER G 6487  SER G 6500  1                                  14    
HELIX  221 221 THR G 6503  GLN G 6509  1                                   7    
HELIX  222 222 PRO G 6515  ALA G 6517  5                                   3    
HELIX  223 223 ASN G 6518  ASN G 6537  1                                  20    
HELIX  224 224 ASP G 6548  ARG G 6556  1                                   9    
HELIX  225 225 GLY H 7025  ASN H 7031  1                                   7    
HELIX  226 226 THR H 7041  MSE H 7047  1                                   7    
HELIX  227 227 THR H 7060  LYS H 7073  1                                  14    
HELIX  228 228 SER H 7077  GLU H 7090  1                                  14    
HELIX  229 229 ASN H 7092  ASP H 7103  1                                  12    
HELIX  230 230 ASP H 7103  TYR H 7112  1                                  10    
HELIX  231 231 PRO H 7114  GLN H 7122  1                                   9    
HELIX  232 232 SER H 7138  ARG H 7140  5                                   3    
HELIX  233 233 HIS H 7142  TRP H 7150  1                                   9    
HELIX  234 234 ILE H 7166  GLY H 7170  5                                   5    
HELIX  235 235 LEU H 7172  GLY H 7178  5                                   7    
HELIX  236 236 ILE H 7179  GLY H 7192  1                                  14    
HELIX  237 237 ARG H 7194  ASP H 7196  5                                   3    
HELIX  238 238 ASN H 7209  LYS H 7214  1                                   6    
HELIX  239 239 GLN H 7229  GLY H 7247  1                                  19    
HELIX  240 240 ASN H 7259  GLU H 7271  1                                  13    
HELIX  241 241 ILE H 7280  SER H 7299  1                                  20    
HELIX  242 242 PRO H 7301  HIS H 7305  5                                   5    
HELIX  243 243 GLU H 7314  VAL H 7328  1                                  15    
HELIX  244 244 SER H 7333  LYS H 7340  1                                   8    
HELIX  245 245 GLN H 7362  THR H 7366  5                                   5    
HELIX  246 246 THR H 7376  LYS H 7385  1                                  10    
HELIX  247 247 THR H 7400  ASN H 7411  1                                  12    
HELIX  248 248 THR H 7429  THR H 7435  1                                   7    
HELIX  249 249 ASN H 7466  TYR H 7469  5                                   4    
HELIX  250 250 ILE H 7470  ASN H 7482  1                                  13    
HELIX  251 251 SER H 7487  SER H 7500  1                                  14    
HELIX  252 252 THR H 7503  GLY H 7510  1                                   8    
HELIX  253 253 PRO H 7515  ALA H 7517  5                                   3    
HELIX  254 254 ASN H 7518  ASN H 7537  1                                  20    
HELIX  255 255 ASP H 7548  LYS H 7554  1                                   7    
SHEET    1   A 5 LEU A 133  SER A 136  0                                        
SHEET    2   A 5 CYS A 198  ASP A 204  1  O  CYS A 202   N  LEU A 133           
SHEET    3   A 5 ALA A 157  THR A 161  1  N  THR A 161   O  ILE A 203           
SHEET    4   A 5 LEU A 251  PHE A 254  1  O  GLN A 253   N  VAL A 160           
SHEET    5   A 5 CYS A 274  ASN A 277  1  O  PHE A 276   N  PHE A 254           
SHEET    1   B 7 GLY A 348  LEU A 349  0                                        
SHEET    2   B 7 ILE A 341  ASP A 345 -1  N  ASP A 345   O  GLY A 348           
SHEET    3   B 7 ILE A 307  PHE A 309  1  N  PHE A 309   O  TRP A 342           
SHEET    4   B 7 THR A 388  GLY A 391  1  O  ILE A 390   N  LEU A 308           
SHEET    5   B 7 VAL A 415  ALA A 418  1  O  PHE A 417   N  GLY A 391           
SHEET    6   B 7 LEU A 442  SER A 445  1  O  ALA A 444   N  ILE A 416           
SHEET    7   B 7 GLY A 463  GLN A 464  1  O  GLY A 463   N  SER A 445           
SHEET    1   C 5 LEU B1133  PHE B1134  0                                        
SHEET    2   C 5 CYS B1198  CYS B1202  1  O  PRO B1200   N  LEU B1133           
SHEET    3   C 5 ALA B1157  THR B1161  1  N  VAL B1159   O  VAL B1201           
SHEET    4   C 5 LEU B1251  PHE B1254  1  O  GLN B1253   N  VAL B1158           
SHEET    5   C 5 THR B1275  ASN B1277  1  O  PHE B1276   N  PHE B1254           
SHEET    1   D 2 PHE B1344  ASP B1345  0                                        
SHEET    2   D 2 GLY B1348  LEU B1349 -1  O  GLY B1348   N  ASP B1345           
SHEET    1   E 4 THR B1388  GLY B1391  0                                        
SHEET    2   E 4 VAL B1415  ALA B1418  1  O  PHE B1417   N  GLY B1391           
SHEET    3   E 4 LEU B1442  SER B1445  1  O  LEU B1442   N  ILE B1416           
SHEET    4   E 4 GLY B1463  GLN B1464  1  O  GLY B1463   N  SER B1445           
SHEET    1   F 2 VAL B1452  LYS B1453  0                                        
SHEET    2   F 2 VAL B1459  PHE B1460 -1  O  PHE B1460   N  VAL B1452           
SHEET    1   G 5 LEU C2133  SER C2136  0                                        
SHEET    2   G 5 PRO C2200  ASP C2204  1  O  CYS C2202   N  LEU C2133           
SHEET    3   G 5 ALA C2157  THR C2161  1  N  THR C2161   O  ILE C2203           
SHEET    4   G 5 LEU C2251  PHE C2254  1  O  GLN C2253   N  VAL C2158           
SHEET    5   G 5 CYS C2274  ASN C2277  1  O  CYS C2274   N  ILE C2252           
SHEET    1   H 6 GLY C2348  LEU C2349  0                                        
SHEET    2   H 6 ILE C2341  ASP C2345 -1  N  ASP C2345   O  GLY C2348           
SHEET    3   H 6 ILE C2307  PHE C2309  1  N  PHE C2309   O  TRP C2342           
SHEET    4   H 6 THR C2388  GLY C2391  1  O  ILE C2390   N  LEU C2308           
SHEET    5   H 6 VAL C2415  ALA C2418  1  O  PHE C2417   N  GLY C2391           
SHEET    6   H 6 LEU C2442  SER C2445  1  O  LEU C2442   N  ILE C2416           
SHEET    1   I 2 LYS C2453  LEU C2454  0                                        
SHEET    2   I 2 ARG C2458  VAL C2459 -1  O  ARG C2458   N  LEU C2454           
SHEET    1   J 4 CYS D3198  PRO D3200  0                                        
SHEET    2   J 4 ALA D3157  VAL D3160  1  N  ALA D3157   O  LEU D3199           
SHEET    3   J 4 LEU D3251  PHE D3254  1  O  GLN D3253   N  VAL D3158           
SHEET    4   J 4 CYS D3274  ASN D3277  1  O  CYS D3274   N  ILE D3252           
SHEET    1   K 3 ILE D3307  PHE D3309  0                                        
SHEET    2   K 3 ILE D3341  ASP D3345  1  O  TRP D3342   N  ILE D3307           
SHEET    3   K 3 GLY D3348  LEU D3349 -1  O  GLY D3348   N  ASP D3345           
SHEET    1   L 4 THR D3388  GLY D3391  0                                        
SHEET    2   L 4 VAL D3415  ALA D3418  1  O  PHE D3417   N  GLY D3391           
SHEET    3   L 4 LEU D3442  SER D3445  1  O  LEU D3442   N  ILE D3416           
SHEET    4   L 4 GLY D3463  GLN D3464  1  O  GLY D3463   N  SER D3445           
SHEET    1   M 2 VAL D3452  LYS D3453  0                                        
SHEET    2   M 2 VAL D3459  PHE D3460 -1  O  PHE D3460   N  VAL D3452           
SHEET    1   N 5 LEU E4133  SER E4136  0                                        
SHEET    2   N 5 CYS E4198  ASP E4204  1  O  PRO E4200   N  LEU E4133           
SHEET    3   N 5 ALA E4157  THR E4161  1  N  ALA E4157   O  LEU E4199           
SHEET    4   N 5 LEU E4251  PHE E4254  1  O  GLN E4253   N  VAL E4160           
SHEET    5   N 5 CYS E4274  ASN E4277  1  O  PHE E4276   N  PHE E4254           
SHEET    1   O 6 ILE E4341  MSE E4343  0                                        
SHEET    2   O 6 ILE E4307  PHE E4309  1  N  ILE E4307   O  TRP E4342           
SHEET    3   O 6 THR E4388  GLY E4391  1  O  THR E4388   N  LEU E4308           
SHEET    4   O 6 VAL E4415  ALA E4418  1  O  PHE E4417   N  GLY E4391           
SHEET    5   O 6 LEU E4442  SER E4445  1  O  LEU E4442   N  ILE E4416           
SHEET    6   O 6 GLY E4463  GLN E4464  1  O  GLY E4463   N  SER E4445           
SHEET    1   P 2 VAL E4452  LEU E4454  0                                        
SHEET    2   P 2 ARG E4458  PHE E4460 -1  O  ARG E4458   N  LEU E4454           
SHEET    1   Q 5 LEU F5133  SER F5136  0                                        
SHEET    2   Q 5 CYS F5198  ASP F5204  1  O  CYS F5202   N  ILE F5135           
SHEET    3   Q 5 ALA F5157  THR F5161  1  N  VAL F5159   O  VAL F5201           
SHEET    4   Q 5 LEU F5251  PHE F5254  1  O  GLN F5253   N  VAL F5158           
SHEET    5   Q 5 THR F5275  ASN F5277  1  O  PHE F5276   N  ILE F5252           
SHEET    1   R 7 GLY F5348  LEU F5349  0                                        
SHEET    2   R 7 ILE F5341  ASP F5345 -1  N  ASP F5345   O  GLY F5348           
SHEET    3   R 7 ILE F5307  PHE F5309  1  N  PHE F5309   O  PHE F5344           
SHEET    4   R 7 THR F5388  GLY F5391  1  O  ILE F5390   N  LEU F5308           
SHEET    5   R 7 VAL F5415  ALA F5418  1  O  PHE F5417   N  GLY F5391           
SHEET    6   R 7 LEU F5442  SER F5445  1  O  LEU F5442   N  ILE F5416           
SHEET    7   R 7 GLY F5463  GLN F5464  1  O  GLY F5463   N  SER F5445           
SHEET    1   S 2 VAL F5452  LYS F5453  0                                        
SHEET    2   S 2 VAL F5459  PHE F5460 -1  O  PHE F5460   N  VAL F5452           
SHEET    1   T 5 LEU G6133  SER G6136  0                                        
SHEET    2   T 5 CYS G6198  ASP G6204  1  O  PRO G6200   N  LEU G6133           
SHEET    3   T 5 ALA G6157  THR G6161  1  N  VAL G6159   O  VAL G6201           
SHEET    4   T 5 LEU G6251  PHE G6254  1  O  GLN G6253   N  VAL G6160           
SHEET    5   T 5 CYS G6274  ASN G6277  1  O  CYS G6274   N  ILE G6252           
SHEET    1   U 5 LEU G6308  PHE G6309  0                                        
SHEET    2   U 5 THR G6388  GLY G6391  1  O  ILE G6390   N  LEU G6308           
SHEET    3   U 5 VAL G6415  ALA G6418  1  O  PHE G6417   N  GLY G6391           
SHEET    4   U 5 LEU G6442  SER G6445  1  O  ALA G6444   N  ALA G6418           
SHEET    5   U 5 GLY G6463  GLN G6464  1  O  GLY G6463   N  SER G6445           
SHEET    1   V 2 VAL G6452  LYS G6453  0                                        
SHEET    2   V 2 VAL G6459  PHE G6460 -1  O  PHE G6460   N  VAL G6452           
SHEET    1   W 5 LEU H7133  SER H7136  0                                        
SHEET    2   W 5 CYS H7198  ASP H7204  1  O  PRO H7200   N  LEU H7133           
SHEET    3   W 5 ALA H7157  VAL H7159  1  N  ALA H7157   O  LEU H7199           
SHEET    4   W 5 LEU H7251  PHE H7254  1  O  GLN H7253   N  VAL H7158           
SHEET    5   W 5 CYS H7274  ASN H7277  1  O  CYS H7274   N  ILE H7252           
SHEET    1   X 7 GLY H7348  LEU H7349  0                                        
SHEET    2   X 7 TRP H7342  ASP H7345 -1  N  ASP H7345   O  GLY H7348           
SHEET    3   X 7 LEU H7308  PHE H7309  1  N  PHE H7309   O  PHE H7344           
SHEET    4   X 7 THR H7388  GLY H7391  1  O  ILE H7390   N  LEU H7308           
SHEET    5   X 7 VAL H7415  ALA H7418  1  O  PHE H7417   N  GLY H7391           
SHEET    6   X 7 LEU H7442  SER H7445  1  O  LEU H7442   N  ILE H7416           
SHEET    7   X 7 GLY H7463  GLN H7464  1  O  GLY H7463   N  SER H7445           
SHEET    1   Y 2 VAL H7452  LYS H7453  0                                        
SHEET    2   Y 2 VAL H7459  PHE H7460 -1  O  PHE H7460   N  VAL H7452           
LINK         C   LEU A  28                 N   MSE A  29     1555   1555  1.33  
LINK         C   MSE A  29                 N   LEU A  30     1555   1555  1.33  
LINK         C   GLY A  37                 N   MSE A  38     1555   1555  1.33  
LINK         C   MSE A  38                 N   ALA A  39     1555   1555  1.33  
LINK         C   GLN A  46                 N   MSE A  47     1555   1555  1.33  
LINK         C   MSE A  47                 N   LEU A  48     1555   1555  1.33  
LINK         C   LYS A  74                 N   MSE A  75     1555   1555  1.33  
LINK         C   MSE A  75                 N   THR A  76     1555   1555  1.34  
LINK         C   ILE A  85                 N   MSE A  86     1555   1555  1.34  
LINK         C   MSE A  86                 N   GLY A  87     1555   1555  1.33  
LINK         C   LEU A 107                 N   MSE A 108     1555   1555  1.33  
LINK         C   MSE A 108                 N   PRO A 109     1555   1555  1.34  
LINK         C   GLY A 176                 N   MSE A 177     1555   1555  1.33  
LINK         C   MSE A 177                 N   GLY A 178     1555   1555  1.32  
LINK         C   TYR A 218                 N   MSE A 219     1555   1555  1.33  
LINK         C   MSE A 219                 N   GLY A 220     1555   1555  1.32  
LINK         C   PHE A 238                 N   MSE A 239     1555   1555  1.33  
LINK         C   MSE A 239                 N   LYS A 240     1555   1555  1.33  
LINK         C   VAL A 324                 N   MSE A 325     1555   1555  1.32  
LINK         C   MSE A 325                 N   SER A 326     1555   1555  1.33  
LINK         C   SER A 326                 N   MSE A 327     1555   1555  1.33  
LINK         C   MSE A 327                 N   VAL A 328     1555   1555  1.32  
LINK         C   TRP A 342                 N   MSE A 343     1555   1555  1.32  
LINK         C   MSE A 343                 N   PHE A 344     1555   1555  1.33  
LINK         C   ALA A 406                 N   MSE A 407     1555   1555  1.32  
LINK         C   MSE A 407                 N   ALA A 408     1555   1555  1.34  
LINK         C   LYS A 538                 N   MSE A 539     1555   1555  1.33  
LINK         C   MSE A 539                 N   ALA A 540     1555   1555  1.33  
LINK         C   LEU B1028                 N   MSE B1029     1555   1555  1.33  
LINK         C   MSE B1029                 N   LEU B1030     1555   1555  1.33  
LINK         C   GLY B1037                 N   MSE B1038     1555   1555  1.34  
LINK         C   MSE B1038                 N   ALA B1039     1555   1555  1.33  
LINK         C   GLN B1046                 N   MSE B1047     1555   1555  1.32  
LINK         C   MSE B1047                 N   LEU B1048     1555   1555  1.33  
LINK         C   LYS B1074                 N   MSE B1075     1555   1555  1.33  
LINK         C   MSE B1075                 N   THR B1076     1555   1555  1.33  
LINK         C   ILE B1085                 N   MSE B1086     1555   1555  1.33  
LINK         C   MSE B1086                 N   GLY B1087     1555   1555  1.33  
LINK         C   LEU B1107                 N   MSE B1108     1555   1555  1.32  
LINK         C   MSE B1108                 N   PRO B1109     1555   1555  1.34  
LINK         C   GLY B1176                 N   MSE B1177     1555   1555  1.33  
LINK         C   MSE B1177                 N   GLY B1178     1555   1555  1.33  
LINK         C   TYR B1218                 N   MSE B1219     1555   1555  1.33  
LINK         C   MSE B1219                 N   GLY B1220     1555   1555  1.33  
LINK         C   PHE B1238                 N   MSE B1239     1555   1555  1.33  
LINK         C   MSE B1239                 N   LYS B1240     1555   1555  1.32  
LINK         C   VAL B1324                 N   MSE B1325     1555   1555  1.33  
LINK         C   MSE B1325                 N   SER B1326     1555   1555  1.33  
LINK         C   SER B1326                 N   MSE B1327     1555   1555  1.34  
LINK         C   MSE B1327                 N   VAL B1328     1555   1555  1.33  
LINK         C   TRP B1342                 N   MSE B1343     1555   1555  1.33  
LINK         C   MSE B1343                 N   PHE B1344     1555   1555  1.33  
LINK         C   ALA B1406                 N   MSE B1407     1555   1555  1.33  
LINK         C   MSE B1407                 N   ALA B1408     1555   1555  1.33  
LINK         C   LYS B1538                 N   MSE B1539     1555   1555  1.33  
LINK         C   MSE B1539                 N   ALA B1540     1555   1555  1.33  
LINK         C   LEU C2028                 N   MSE C2029     1555   1555  1.33  
LINK         C   MSE C2029                 N   LEU C2030     1555   1555  1.32  
LINK         C   GLY C2037                 N   MSE C2038     1555   1555  1.33  
LINK         C   MSE C2038                 N   ALA C2039     1555   1555  1.33  
LINK         C   GLN C2046                 N   MSE C2047     1555   1555  1.33  
LINK         C   MSE C2047                 N   LEU C2048     1555   1555  1.33  
LINK         C   LYS C2074                 N   MSE C2075     1555   1555  1.33  
LINK         C   MSE C2075                 N   THR C2076     1555   1555  1.33  
LINK         C   ILE C2085                 N   MSE C2086     1555   1555  1.32  
LINK         C   MSE C2086                 N   GLY C2087     1555   1555  1.33  
LINK         C   LEU C2107                 N   MSE C2108     1555   1555  1.33  
LINK         C   MSE C2108                 N   PRO C2109     1555   1555  1.34  
LINK         C   GLY C2176                 N   MSE C2177     1555   1555  1.33  
LINK         C   MSE C2177                 N   GLY C2178     1555   1555  1.33  
LINK         C   TYR C2218                 N   MSE C2219     1555   1555  1.34  
LINK         C   MSE C2219                 N   GLY C2220     1555   1555  1.33  
LINK         C   PHE C2238                 N   MSE C2239     1555   1555  1.33  
LINK         C   MSE C2239                 N   LYS C2240     1555   1555  1.33  
LINK         C   VAL C2324                 N   MSE C2325     1555   1555  1.32  
LINK         C   MSE C2325                 N   SER C2326     1555   1555  1.33  
LINK         C   SER C2326                 N   MSE C2327     1555   1555  1.33  
LINK         C   MSE C2327                 N   VAL C2328     1555   1555  1.33  
LINK         C   TRP C2342                 N   MSE C2343     1555   1555  1.33  
LINK         C   MSE C2343                 N   PHE C2344     1555   1555  1.33  
LINK         C   ALA C2406                 N   MSE C2407     1555   1555  1.33  
LINK         C   MSE C2407                 N   ALA C2408     1555   1555  1.33  
LINK         C   LYS C2538                 N   MSE C2539     1555   1555  1.33  
LINK         C   MSE C2539                 N   ALA C2540     1555   1555  1.33  
LINK         C   LEU D3028                 N   MSE D3029     1555   1555  1.33  
LINK         C   MSE D3029                 N   LEU D3030     1555   1555  1.33  
LINK         C   GLY D3037                 N   MSE D3038     1555   1555  1.33  
LINK         C   MSE D3038                 N   ALA D3039     1555   1555  1.32  
LINK         C   GLN D3046                 N   MSE D3047     1555   1555  1.32  
LINK         C   MSE D3047                 N   LEU D3048     1555   1555  1.33  
LINK         C   LYS D3074                 N   MSE D3075     1555   1555  1.32  
LINK         C   MSE D3075                 N   THR D3076     1555   1555  1.33  
LINK         C   ILE D3085                 N   MSE D3086     1555   1555  1.33  
LINK         C   MSE D3086                 N   GLY D3087     1555   1555  1.33  
LINK         C   LEU D3107                 N   MSE D3108     1555   1555  1.32  
LINK         C   MSE D3108                 N   PRO D3109     1555   1555  1.35  
LINK         C   GLY D3176                 N   MSE D3177     1555   1555  1.34  
LINK         C   MSE D3177                 N   GLY D3178     1555   1555  1.33  
LINK         C   TYR D3218                 N   MSE D3219     1555   1555  1.33  
LINK         C   MSE D3219                 N   GLY D3220     1555   1555  1.32  
LINK         C   PHE D3238                 N   MSE D3239     1555   1555  1.33  
LINK         C   MSE D3239                 N   LYS D3240     1555   1555  1.33  
LINK         C   VAL D3324                 N   MSE D3325     1555   1555  1.34  
LINK         C   MSE D3325                 N   SER D3326     1555   1555  1.34  
LINK         C   SER D3326                 N   MSE D3327     1555   1555  1.33  
LINK         C   MSE D3327                 N   VAL D3328     1555   1555  1.33  
LINK         C   TRP D3342                 N   MSE D3343     1555   1555  1.33  
LINK         C   MSE D3343                 N   PHE D3344     1555   1555  1.33  
LINK         C   ALA D3406                 N   MSE D3407     1555   1555  1.33  
LINK         C   MSE D3407                 N   ALA D3408     1555   1555  1.33  
LINK         C   LYS D3538                 N   MSE D3539     1555   1555  1.33  
LINK         C   MSE D3539                 N   ALA D3540     1555   1555  1.33  
LINK         C   LEU E4028                 N   MSE E4029     1555   1555  1.33  
LINK         C   MSE E4029                 N   LEU E4030     1555   1555  1.33  
LINK         C   GLY E4037                 N   MSE E4038     1555   1555  1.32  
LINK         C   MSE E4038                 N   ALA E4039     1555   1555  1.32  
LINK         C   GLN E4046                 N   MSE E4047     1555   1555  1.33  
LINK         C   MSE E4047                 N   LEU E4048     1555   1555  1.33  
LINK         C   LYS E4074                 N   MSE E4075     1555   1555  1.33  
LINK         C   MSE E4075                 N   THR E4076     1555   1555  1.34  
LINK         C   ILE E4085                 N   MSE E4086     1555   1555  1.34  
LINK         C   MSE E4086                 N   GLY E4087     1555   1555  1.33  
LINK         C   LEU E4107                 N   MSE E4108     1555   1555  1.33  
LINK         C   MSE E4108                 N   PRO E4109     1555   1555  1.35  
LINK         C   GLY E4176                 N   MSE E4177     1555   1555  1.33  
LINK         C   MSE E4177                 N   GLY E4178     1555   1555  1.33  
LINK         C   TYR E4218                 N   MSE E4219     1555   1555  1.32  
LINK         C   MSE E4219                 N   GLY E4220     1555   1555  1.32  
LINK         C   PHE E4238                 N   MSE E4239     1555   1555  1.32  
LINK         C   MSE E4239                 N   LYS E4240     1555   1555  1.33  
LINK         C   VAL E4324                 N   MSE E4325     1555   1555  1.33  
LINK         C   MSE E4325                 N   SER E4326     1555   1555  1.33  
LINK         C   SER E4326                 N   MSE E4327     1555   1555  1.33  
LINK         C   MSE E4327                 N   VAL E4328     1555   1555  1.33  
LINK         C   TRP E4342                 N   MSE E4343     1555   1555  1.33  
LINK         C   MSE E4343                 N   PHE E4344     1555   1555  1.34  
LINK         C   ALA E4406                 N   MSE E4407     1555   1555  1.33  
LINK         C   MSE E4407                 N   ALA E4408     1555   1555  1.33  
LINK         C   LYS E4538                 N   MSE E4539     1555   1555  1.33  
LINK         C   MSE E4539                 N   ALA E4540     1555   1555  1.33  
LINK         C   LEU F5028                 N   MSE F5029     1555   1555  1.33  
LINK         C   MSE F5029                 N   LEU F5030     1555   1555  1.33  
LINK         C   GLY F5037                 N   MSE F5038     1555   1555  1.33  
LINK         C   MSE F5038                 N   ALA F5039     1555   1555  1.33  
LINK         C   GLN F5046                 N   MSE F5047     1555   1555  1.33  
LINK         C   MSE F5047                 N   LEU F5048     1555   1555  1.33  
LINK         C   LYS F5074                 N   MSE F5075     1555   1555  1.33  
LINK         C   MSE F5075                 N   THR F5076     1555   1555  1.32  
LINK         C   ILE F5085                 N   MSE F5086     1555   1555  1.32  
LINK         C   MSE F5086                 N   GLY F5087     1555   1555  1.33  
LINK         C   LEU F5107                 N   MSE F5108     1555   1555  1.33  
LINK         C   MSE F5108                 N   PRO F5109     1555   1555  1.34  
LINK         C   GLY F5176                 N   MSE F5177     1555   1555  1.33  
LINK         C   MSE F5177                 N   GLY F5178     1555   1555  1.33  
LINK         C   TYR F5218                 N   MSE F5219     1555   1555  1.33  
LINK         C   MSE F5219                 N   GLY F5220     1555   1555  1.33  
LINK         C   PHE F5238                 N   MSE F5239     1555   1555  1.33  
LINK         C   MSE F5239                 N   LYS F5240     1555   1555  1.33  
LINK         C   VAL F5324                 N   MSE F5325     1555   1555  1.32  
LINK         C   MSE F5325                 N   SER F5326     1555   1555  1.33  
LINK         C   SER F5326                 N   MSE F5327     1555   1555  1.33  
LINK         C   MSE F5327                 N   VAL F5328     1555   1555  1.33  
LINK         C   TRP F5342                 N   MSE F5343     1555   1555  1.33  
LINK         C   MSE F5343                 N   PHE F5344     1555   1555  1.33  
LINK         C   ALA F5406                 N   MSE F5407     1555   1555  1.33  
LINK         C   MSE F5407                 N   ALA F5408     1555   1555  1.33  
LINK         C   LYS F5538                 N   MSE F5539     1555   1555  1.33  
LINK         C   MSE F5539                 N   ALA F5540     1555   1555  1.33  
LINK         C   LEU G6028                 N   MSE G6029     1555   1555  1.33  
LINK         C   MSE G6029                 N   LEU G6030     1555   1555  1.32  
LINK         C   GLY G6037                 N   MSE G6038     1555   1555  1.33  
LINK         C   MSE G6038                 N   ALA G6039     1555   1555  1.33  
LINK         C   GLN G6046                 N   MSE G6047     1555   1555  1.33  
LINK         C   MSE G6047                 N   LEU G6048     1555   1555  1.32  
LINK         C   LYS G6074                 N   MSE G6075     1555   1555  1.33  
LINK         C   MSE G6075                 N   THR G6076     1555   1555  1.33  
LINK         C   ILE G6085                 N   MSE G6086     1555   1555  1.33  
LINK         C   MSE G6086                 N   GLY G6087     1555   1555  1.32  
LINK         C   LEU G6107                 N   MSE G6108     1555   1555  1.33  
LINK         C   MSE G6108                 N   PRO G6109     1555   1555  1.35  
LINK         C   GLY G6176                 N   MSE G6177     1555   1555  1.33  
LINK         C   MSE G6177                 N   GLY G6178     1555   1555  1.33  
LINK         C   TYR G6218                 N   MSE G6219     1555   1555  1.33  
LINK         C   MSE G6219                 N   GLY G6220     1555   1555  1.33  
LINK         C   PHE G6238                 N   MSE G6239     1555   1555  1.33  
LINK         C   MSE G6239                 N   LYS G6240     1555   1555  1.33  
LINK         C   VAL G6324                 N   MSE G6325     1555   1555  1.33  
LINK         C   MSE G6325                 N   SER G6326     1555   1555  1.33  
LINK         C   SER G6326                 N   MSE G6327     1555   1555  1.33  
LINK         C   MSE G6327                 N   VAL G6328     1555   1555  1.33  
LINK         C   TRP G6342                 N   MSE G6343     1555   1555  1.33  
LINK         C   MSE G6343                 N   PHE G6344     1555   1555  1.32  
LINK         C   ALA G6406                 N   MSE G6407     1555   1555  1.33  
LINK         C   MSE G6407                 N   ALA G6408     1555   1555  1.33  
LINK         C   LYS G6538                 N   MSE G6539     1555   1555  1.32  
LINK         C   MSE G6539                 N   ALA G6540     1555   1555  1.33  
LINK         C   LEU H7028                 N   MSE H7029     1555   1555  1.33  
LINK         C   MSE H7029                 N   LEU H7030     1555   1555  1.32  
LINK         C   GLY H7037                 N   MSE H7038     1555   1555  1.33  
LINK         C   MSE H7038                 N   ALA H7039     1555   1555  1.33  
LINK         C   GLN H7046                 N   MSE H7047     1555   1555  1.33  
LINK         C   MSE H7047                 N   LEU H7048     1555   1555  1.33  
LINK         C   LYS H7074                 N   MSE H7075     1555   1555  1.33  
LINK         C   MSE H7075                 N   THR H7076     1555   1555  1.33  
LINK         C   ILE H7085                 N   MSE H7086     1555   1555  1.33  
LINK         C   MSE H7086                 N   GLY H7087     1555   1555  1.32  
LINK         C   LEU H7107                 N   MSE H7108     1555   1555  1.33  
LINK         C   MSE H7108                 N   PRO H7109     1555   1555  1.35  
LINK         C   GLY H7176                 N   MSE H7177     1555   1555  1.33  
LINK         C   MSE H7177                 N   GLY H7178     1555   1555  1.32  
LINK         C   TYR H7218                 N   MSE H7219     1555   1555  1.33  
LINK         C   MSE H7219                 N   GLY H7220     1555   1555  1.32  
LINK         C   PHE H7238                 N   MSE H7239     1555   1555  1.33  
LINK         C   MSE H7239                 N   LYS H7240     1555   1555  1.33  
LINK         C   VAL H7324                 N   MSE H7325     1555   1555  1.32  
LINK         C   MSE H7325                 N   SER H7326     1555   1555  1.33  
LINK         C   SER H7326                 N   MSE H7327     1555   1555  1.33  
LINK         C   MSE H7327                 N   VAL H7328     1555   1555  1.32  
LINK         C   TRP H7342                 N   MSE H7343     1555   1555  1.33  
LINK         C   MSE H7343                 N   PHE H7344     1555   1555  1.33  
LINK         C   ALA H7406                 N   MSE H7407     1555   1555  1.33  
LINK         C   MSE H7407                 N   ALA H7408     1555   1555  1.33  
LINK         C   LYS H7538                 N   MSE H7539     1555   1555  1.33  
LINK         C   MSE H7539                 N   ALA H7540     1555   1555  1.33  
CISPEP   1 THR A  113    PRO A  114          0         0.07                     
CISPEP   2 ASN A  421    PRO A  422          0         0.23                     
CISPEP   3 TYR A  543    PRO A  544          0        -0.28                     
CISPEP   4 THR B 1113    PRO B 1114          0        -0.21                     
CISPEP   5 ASN B 1421    PRO B 1422          0         0.45                     
CISPEP   6 TYR B 1543    PRO B 1544          0         0.16                     
CISPEP   7 THR C 2113    PRO C 2114          0        -0.36                     
CISPEP   8 ASN C 2421    PRO C 2422          0        -0.32                     
CISPEP   9 TYR C 2543    PRO C 2544          0         0.01                     
CISPEP  10 THR D 3113    PRO D 3114          0         0.40                     
CISPEP  11 ASN D 3421    PRO D 3422          0         0.16                     
CISPEP  12 TYR D 3543    PRO D 3544          0        -0.13                     
CISPEP  13 THR E 4113    PRO E 4114          0         0.28                     
CISPEP  14 ASN E 4421    PRO E 4422          0         0.31                     
CISPEP  15 TYR E 4543    PRO E 4544          0        -0.07                     
CISPEP  16 THR F 5113    PRO F 5114          0        -0.17                     
CISPEP  17 ASN F 5421    PRO F 5422          0         0.08                     
CISPEP  18 TYR F 5543    PRO F 5544          0        -0.47                     
CISPEP  19 THR G 6113    PRO G 6114          0         0.12                     
CISPEP  20 ASN G 6421    PRO G 6422          0         0.26                     
CISPEP  21 TYR G 6543    PRO G 6544          0        -0.15                     
CISPEP  22 THR H 7113    PRO H 7114          0         0.46                     
CISPEP  23 ASN H 7421    PRO H 7422          0        -0.03                     
CISPEP  24 TYR H 7543    PRO H 7544          0         0.52                     
SITE     1 AC1  3 GLU A 255  ASP A 256  ASP A 279                               
SITE     1 AC2  3 GLU B1255  ASP B1256  ASP B1279                               
SITE     1 AC3  3 GLU C2255  ASP C2256  ASP C2279                               
SITE     1 AC4  3 GLU D3255  ASP D3256  ASP D3279                               
SITE     1 AC5  3 GLU E4255  ASP E4256  ASP E4279                               
SITE     1 AC6  3 GLU F5255  ASP F5256  ASP F5279                               
SITE     1 AC7  3 GLU G6255  ASP G6256  ASP G6279                               
SITE     1 AC8  3 GLU H7255  ASP H7256  ASP H7279                               
SITE     1 AC9 21 ARG A 165  ASN A 259  THR A 283  LEU A 310                    
SITE     2 AC9 21 ALA A 312  GLY A 313  GLU A 314  ALA A 315                    
SITE     3 AC9 21 ASP A 345  LYS A 346  VAL A 392  ALA A 393                    
SITE     4 AC9 21 GLY A 394  ALA A 395  LEU A 398  LEU A 419                    
SITE     5 AC9 21 SER A 420  ASN A 421  GLY A 446  GLY A 465                    
SITE     6 AC9 21 ASN A 467                                                     
SITE     1 BC1 10 HIS A 154  GLY A 192  ILE A 193  ARG A 194                    
SITE     2 BC1 10 ARG A 197  ILE A 479  LEU A 480  ARG A 542                    
SITE     3 BC1 10 TYR A 552  ARG A 556                                          
SITE     1 BC2 20 ASN B1259  THR B1283  LEU B1310  ALA B1312                    
SITE     2 BC2 20 GLY B1313  GLU B1314  ALA B1315  ASP B1345                    
SITE     3 BC2 20 LYS B1346  VAL B1392  ALA B1393  GLY B1394                    
SITE     4 BC2 20 ALA B1395  LEU B1398  LEU B1419  SER B1420                    
SITE     5 BC2 20 ASN B1421  GLY B1465  ASN B1467  HOH B8059                    
SITE     1 BC3 12 HIS B1154  LYS B1156  GLY B1192  ILE B1193                    
SITE     2 BC3 12 ARG B1194  ARG B1197  ILE B1479  LEU B1480                    
SITE     3 BC3 12 ASN B1482  ARG B1542  TYR B1552  ARG B1556                    
SITE     1 BC4 21 ARG C2165  ASN C2259  THR C2283  LEU C2310                    
SITE     2 BC4 21 ALA C2312  GLY C2313  GLU C2314  ALA C2315                    
SITE     3 BC4 21 ASP C2345  LYS C2346  VAL C2392  ALA C2393                    
SITE     4 BC4 21 GLY C2394  ALA C2395  LEU C2398  LEU C2419                    
SITE     5 BC4 21 SER C2420  ASN C2421  GLY C2446  GLY C2465                    
SITE     6 BC4 21 ASN C2467                                                     
SITE     1 BC5 11 HIS C2154  GLY C2192  ILE C2193  ARG C2194                    
SITE     2 BC5 11 ARG C2197  ILE C2479  LEU C2480  ASN C2482                    
SITE     3 BC5 11 ARG C2542  TYR C2552  ARG C2556                               
SITE     1 BC6 22 ARG D3165  ASN D3259  THR D3283  LEU D3310                    
SITE     2 BC6 22 GLY D3311  ALA D3312  GLY D3313  GLU D3314                    
SITE     3 BC6 22 ALA D3315  ASP D3345  LYS D3346  VAL D3392                    
SITE     4 BC6 22 ALA D3393  GLY D3394  ALA D3395  LEU D3398                    
SITE     5 BC6 22 LEU D3419  SER D3420  ASN D3421  GLY D3446                    
SITE     6 BC6 22 GLY D3465  ASN D3467                                          
SITE     1 BC7 10 HIS D3154  LYS D3156  GLY D3192  ILE D3193                    
SITE     2 BC7 10 ARG D3194  ILE D3479  LEU D3480  ARG D3542                    
SITE     3 BC7 10 TYR D3552  ARG D3556                                          
SITE     1 BC8 23 ARG E4165  ASN E4259  THR E4283  LEU E4310                    
SITE     2 BC8 23 GLY E4311  ALA E4312  GLY E4313  GLU E4314                    
SITE     3 BC8 23 ALA E4315  PHE E4344  ASP E4345  LYS E4346                    
SITE     4 BC8 23 VAL E4392  ALA E4393  GLY E4394  ALA E4395                    
SITE     5 BC8 23 LEU E4398  LEU E4419  SER E4420  ASN E4421                    
SITE     6 BC8 23 GLY E4446  GLY E4465  ASN E4467                               
SITE     1 BC9 10 HIS E4154  LYS E4156  GLY E4192  ILE E4193                    
SITE     2 BC9 10 ARG E4194  ARG E4197  LEU E4480  ARG E4542                    
SITE     3 BC9 10 TYR E4552  ARG E4556                                          
SITE     1 CC1 21 ARG F5165  ASN F5259  THR F5283  LEU F5310                    
SITE     2 CC1 21 GLY F5311  ALA F5312  GLY F5313  GLU F5314                    
SITE     3 CC1 21 ALA F5315  ASP F5345  LYS F5346  VAL F5392                    
SITE     4 CC1 21 ALA F5393  GLY F5394  ALA F5395  LEU F5398                    
SITE     5 CC1 21 LEU F5419  ASN F5421  GLY F5446  GLY F5465                    
SITE     6 CC1 21 ASN F5467                                                     
SITE     1 CC2  8 GLY F5192  ILE F5193  ARG F5194  ARG F5197                    
SITE     2 CC2  8 ILE F5479  LEU F5480  ARG F5542  ARG F5556                    
SITE     1 CC3 21 ARG G6165  ASN G6259  THR G6283  LEU G6310                    
SITE     2 CC3 21 GLY G6311  ALA G6312  GLY G6313  GLU G6314                    
SITE     3 CC3 21 ALA G6315  ASP G6345  LYS G6346  ALA G6393                    
SITE     4 CC3 21 GLY G6394  ALA G6395  LEU G6398  LEU G6419                    
SITE     5 CC3 21 SER G6420  ASN G6421  GLY G6446  GLY G6465                    
SITE     6 CC3 21 ASN G6467                                                     
SITE     1 CC4  9 GLY G6192  ILE G6193  ARG G6194  ARG G6197                    
SITE     2 CC4  9 ILE G6479  LEU G6480  ARG G6542  TYR G6552                    
SITE     3 CC4  9 ARG G6556                                                     
SITE     1 CC5 19 ARG H7165  THR H7283  LEU H7310  GLY H7311                    
SITE     2 CC5 19 ALA H7312  GLY H7313  GLU H7314  ALA H7315                    
SITE     3 CC5 19 ASP H7345  LYS H7346  VAL H7392  ALA H7393                    
SITE     4 CC5 19 ALA H7395  LEU H7398  LEU H7419  ASN H7421                    
SITE     5 CC5 19 GLY H7446  GLY H7465  ASN H7467                               
SITE     1 CC6  8 ILE H7193  ARG H7194  ARG H7197  ILE H7479                    
SITE     2 CC6  8 LEU H7480  ARG H7542  TYR H7552  ARG H7556                    
CRYST1  113.300  119.000  125.900 116.50  94.80 102.80 P 1           8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.008826  0.002005  0.001936        0.00000                         
SCALE2      0.000000  0.008618  0.004693        0.00000                         
SCALE3      0.000000  0.000000  0.009076        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system