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Database: PDB
Entry: 2GLJ
LinkDB: 2GLJ
Original site: 2GLJ 
HEADER    HYDROLASE                               04-APR-06   2GLJ              
TITLE     CRYSTAL STRUCTURE OF AMINOPEPTIDASE I FROM CLOSTRIDIUM                
TITLE    2 ACETOBUTYLICUM                                                       
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROBABLE M18-FAMILY AMINOPEPTIDASE 1;                      
COMPND   3 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q,            
COMPND   4 R, S, T, U, V, W, X;                                                 
COMPND   5 EC: 3.4.11.-;                                                        
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: CLOSTRIDIUM ACETOBUTYLICUM;                     
SOURCE   3 ORGANISM_TAXID: 1488;                                                
SOURCE   4 GENE: APEA;                                                          
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    AMINOPEPTIDASE I, NYSGXRC, STRUCTURAL GENOMICS, PSI,                  
KEYWDS   2 PROTEIN STRUCTURE INITIATIVE, NEW YORK SGX RESEARCH CENTER           
KEYWDS   3 FOR STRUCTURAL GENOMICS, HYDROLASE                                   
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    T.MIN,L.SHAPIRO,S.K.BURLEY,NEW YORK SGX RESEARCH CENTER FOR           
AUTHOR   2 STRUCTURAL GENOMICS (NYSGXRC)                                        
REVDAT   2   24-FEB-09 2GLJ    1       VERSN                                    
REVDAT   1   13-JUN-06 2GLJ    0                                                
JRNL        AUTH   T.MIN,L.SHAPIRO                                              
JRNL        TITL   CRYSTAL STRUCTURE OF AMINOPEPTIDASE I FROM                   
JRNL        TITL 2 CLOSTRIDIUM ACETOBUTYLICUM                                   
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.20 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.1                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU,             
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : NULL                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.20                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.95                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 2.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 192230.620                     
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000                         
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 60.1                           
REMARK   3   NUMBER OF REFLECTIONS             : 240681                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.250                           
REMARK   3   FREE R VALUE                     : 0.297                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.300                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 10245                           
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.003                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 6                            
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.20                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.40                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 35.70                        
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 22828                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3260                       
REMARK   3   BIN FREE R VALUE                    : 0.3750                       
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 4.20                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 1003                         
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.012                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 85944                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 48                                      
REMARK   3   SOLVENT ATOMS            : 5233                                    
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 30.60                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 0.00000                                              
REMARK   3    B22 (A**2) : 0.00000                                              
REMARK   3    B33 (A**2) : 0.00000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.41                            
REMARK   3   ESD FROM SIGMAA              (A) : 0.60                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.52                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.74                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.008                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.30                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 23.10                           
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.79                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : GROUP                                     
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : FLAT MODEL                                           
REMARK   3   KSOL        : 0.18                                                 
REMARK   3   BSOL        : 10.00                                                
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM                              
REMARK   3  PARAMETER FILE  2  : WATER_REP.PARAM                                
REMARK   3  PARAMETER FILE  3  : ION.PARAM                                      
REMARK   3  PARAMETER FILE  4  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : PROTEIN.TOP                                    
REMARK   3  TOPOLOGY FILE  2   : WATER.TOP                                      
REMARK   3  TOPOLOGY FILE  3   : ION.TOP                                        
REMARK   3  TOPOLOGY FILE  4   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 2GLJ COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 05-APR-06.                  
REMARK 100 THE RCSB ID CODE IS RCSB037267.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 01-JAN-05                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : NSLS                               
REMARK 200  BEAMLINE                       : X29A                               
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.978                              
REMARK 200  MONOCHROMATOR                  : SI(111)DOUBLE CRYSTAL              
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : CBASS, DENZO                       
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 311235                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.800                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 78.5                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 51.43                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.53                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 7% ETOH, 0.05M NACL, 0.01M MNCL2,        
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K                     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC                
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 105790 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 176750 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -576.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I,            
REMARK 350                    AND CHAINS: J, K, L                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC                
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 105840 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 177090 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -575.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: M, N, O, P, Q, R, S, T, U,            
REMARK 350                    AND CHAINS: V, W, X                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     LEU A   320                                                      
REMARK 465     CYS A   321                                                      
REMARK 465     GLY A   322                                                      
REMARK 465     ASP A   323                                                      
REMARK 465     TYR A   324                                                      
REMARK 465     LEU B   320                                                      
REMARK 465     CYS B   321                                                      
REMARK 465     GLY B   322                                                      
REMARK 465     ASP B   323                                                      
REMARK 465     TYR B   324                                                      
REMARK 465     LEU C   320                                                      
REMARK 465     CYS C   321                                                      
REMARK 465     GLY C   322                                                      
REMARK 465     ASP C   323                                                      
REMARK 465     TYR C   324                                                      
REMARK 465     LEU D   320                                                      
REMARK 465     CYS D   321                                                      
REMARK 465     GLY D   322                                                      
REMARK 465     ASP D   323                                                      
REMARK 465     TYR D   324                                                      
REMARK 465     LEU E   320                                                      
REMARK 465     CYS E   321                                                      
REMARK 465     GLY E   322                                                      
REMARK 465     ASP E   323                                                      
REMARK 465     TYR E   324                                                      
REMARK 465     LEU F   320                                                      
REMARK 465     CYS F   321                                                      
REMARK 465     GLY F   322                                                      
REMARK 465     ASP F   323                                                      
REMARK 465     TYR F   324                                                      
REMARK 465     LEU G   320                                                      
REMARK 465     CYS G   321                                                      
REMARK 465     GLY G   322                                                      
REMARK 465     ASP G   323                                                      
REMARK 465     TYR G   324                                                      
REMARK 465     LEU H   320                                                      
REMARK 465     CYS H   321                                                      
REMARK 465     GLY H   322                                                      
REMARK 465     ASP H   323                                                      
REMARK 465     TYR H   324                                                      
REMARK 465     LEU I   320                                                      
REMARK 465     CYS I   321                                                      
REMARK 465     GLY I   322                                                      
REMARK 465     ASP I   323                                                      
REMARK 465     TYR I   324                                                      
REMARK 465     LEU J   320                                                      
REMARK 465     CYS J   321                                                      
REMARK 465     GLY J   322                                                      
REMARK 465     ASP J   323                                                      
REMARK 465     TYR J   324                                                      
REMARK 465     LEU K   320                                                      
REMARK 465     CYS K   321                                                      
REMARK 465     GLY K   322                                                      
REMARK 465     ASP K   323                                                      
REMARK 465     TYR K   324                                                      
REMARK 465     LEU L   320                                                      
REMARK 465     CYS L   321                                                      
REMARK 465     GLY L   322                                                      
REMARK 465     ASP L   323                                                      
REMARK 465     TYR L   324                                                      
REMARK 465     LEU M   320                                                      
REMARK 465     CYS M   321                                                      
REMARK 465     GLY M   322                                                      
REMARK 465     ASP M   323                                                      
REMARK 465     TYR M   324                                                      
REMARK 465     LEU N   320                                                      
REMARK 465     CYS N   321                                                      
REMARK 465     GLY N   322                                                      
REMARK 465     ASP N   323                                                      
REMARK 465     TYR N   324                                                      
REMARK 465     LEU O   320                                                      
REMARK 465     CYS O   321                                                      
REMARK 465     GLY O   322                                                      
REMARK 465     ASP O   323                                                      
REMARK 465     TYR O   324                                                      
REMARK 465     LEU P   320                                                      
REMARK 465     CYS P   321                                                      
REMARK 465     GLY P   322                                                      
REMARK 465     ASP P   323                                                      
REMARK 465     TYR P   324                                                      
REMARK 465     LEU Q   320                                                      
REMARK 465     CYS Q   321                                                      
REMARK 465     GLY Q   322                                                      
REMARK 465     ASP Q   323                                                      
REMARK 465     TYR Q   324                                                      
REMARK 465     LEU R   320                                                      
REMARK 465     CYS R   321                                                      
REMARK 465     GLY R   322                                                      
REMARK 465     ASP R   323                                                      
REMARK 465     TYR R   324                                                      
REMARK 465     LEU S   320                                                      
REMARK 465     CYS S   321                                                      
REMARK 465     GLY S   322                                                      
REMARK 465     ASP S   323                                                      
REMARK 465     TYR S   324                                                      
REMARK 465     LEU T   320                                                      
REMARK 465     CYS T   321                                                      
REMARK 465     GLY T   322                                                      
REMARK 465     ASP T   323                                                      
REMARK 465     TYR T   324                                                      
REMARK 465     LEU U   320                                                      
REMARK 465     CYS U   321                                                      
REMARK 465     GLY U   322                                                      
REMARK 465     ASP U   323                                                      
REMARK 465     TYR U   324                                                      
REMARK 465     LEU V   320                                                      
REMARK 465     CYS V   321                                                      
REMARK 465     GLY V   322                                                      
REMARK 465     ASP V   323                                                      
REMARK 465     TYR V   324                                                      
REMARK 465     LEU W   320                                                      
REMARK 465     CYS W   321                                                      
REMARK 465     GLY W   322                                                      
REMARK 465     ASP W   323                                                      
REMARK 465     TYR W   324                                                      
REMARK 465     LEU X   320                                                      
REMARK 465     CYS X   321                                                      
REMARK 465     GLY X   322                                                      
REMARK 465     ASP X   323                                                      
REMARK 465     TYR X   324                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    ASN C   439     O    HOH C  6210              2.00            
REMARK 500   O    HOH U  6059     O    HOH U  6201              2.03            
REMARK 500   O    ASP W    62     O    HOH W  6118              2.06            
REMARK 500   O    HOH H  6018     O    HOH H  6221              2.07            
REMARK 500   O    ILE B   135     N    LYS B   137              2.08            
REMARK 500   O    ILE A   135     N    LYS A   137              2.08            
REMARK 500   O    GLY E   247     O    HOH E  6134              2.09            
REMARK 500   O    ILE N   135     N    LYS N   137              2.09            
REMARK 500   O    ILE F   135     N    LYS F   137              2.09            
REMARK 500   O    ALA I   420     O    HOH I  6103              2.09            
REMARK 500   O    ARG V    42     N    CYS V    44              2.09            
REMARK 500   O    GLY U   304     O    HOH U  6096              2.09            
REMARK 500   O    ILE O   135     N    LYS O   137              2.09            
REMARK 500   OD2  ASP L   325     O    HOH L  6065              2.10            
REMARK 500   O    ILE I   135     N    LYS I   137              2.10            
REMARK 500   O    ILE P   135     N    LYS P   137              2.10            
REMARK 500   O    GLN F   139     O    HOH F  6014              2.10            
REMARK 500   O    ILE J   135     N    LYS J   137              2.10            
REMARK 500   O    ILE E   135     N    LYS E   137              2.10            
REMARK 500   O    ILE X   135     N    LYS X   137              2.10            
REMARK 500   O    ILE D   135     N    LYS D   137              2.11            
REMARK 500   O    ILE G   135     N    LYS G   137              2.11            
REMARK 500   O    ILE R   135     N    LYS R   137              2.11            
REMARK 500   O    ARG P    42     N    CYS P    44              2.11            
REMARK 500   O    ARG C    42     N    CYS C    44              2.11            
REMARK 500   O    ILE W   135     N    LYS W   137              2.11            
REMARK 500   O    ILE H   135     N    LYS H   137              2.11            
REMARK 500   O    ARG O    42     N    CYS O    44              2.11            
REMARK 500   O    ILE U   135     N    LYS U   137              2.11            
REMARK 500   O    ILE T   135     N    LYS T   137              2.11            
REMARK 500   O    ARG D    42     N    CYS D    44              2.11            
REMARK 500   O    ILE V   135     N    LYS V   137              2.11            
REMARK 500   O    ARG A    42     N    CYS A    44              2.11            
REMARK 500   O    ILE L   135     N    LYS L   137              2.11            
REMARK 500   O    ARG S    42     N    CYS S    44              2.11            
REMARK 500   O    ILE C   135     N    LYS C   137              2.12            
REMARK 500   O    ARG X    42     N    CYS X    44              2.12            
REMARK 500   O    ARG B    42     N    CYS B    44              2.12            
REMARK 500   O    ILE S   135     N    LYS S   137              2.12            
REMARK 500   O    ARG J    42     N    CYS J    44              2.12            
REMARK 500   O    ARG N    42     N    CYS N    44              2.12            
REMARK 500   O    GLN T   185     O    HOH T  6042              2.12            
REMARK 500   O    ARG L    42     N    CYS L    44              2.12            
REMARK 500   O    ARG I    42     N    CYS I    44              2.12            
REMARK 500   N    LYS G   154     O    HOH G  6109              2.12            
REMARK 500   O    ILE Q   135     N    LYS Q   137              2.12            
REMARK 500   OH   TYR F   421     O    HOH F  6210              2.13            
REMARK 500   O    ARG T    42     N    CYS T    44              2.13            
REMARK 500   O    ARG R    42     N    CYS R    44              2.13            
REMARK 500   O    ARG H    42     N    CYS H    44              2.13            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     108 CLOSE CONTACTS.                               
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   NZ   LYS D    66     NZ   LYS W   284     1654     2.11            
REMARK 500   OG   SER E   400     OD1  ASP K   325     1665     2.17            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A  10     -164.70     54.15                                   
REMARK 500    TRP A  13     -172.82    -65.00                                   
REMARK 500    ASP A  14      -75.07     71.58                                   
REMARK 500    TYR A  16      -97.66    -58.74                                   
REMARK 500    ASP A  17     -115.95     44.26                                   
REMARK 500    ASP A  18       -9.32     60.69                                   
REMARK 500    LYS A  19      -25.61     68.26                                   
REMARK 500    GLN A  20      -71.39    -91.57                                   
REMARK 500    VAL A  24        5.44    -64.30                                   
REMARK 500    PHE A  25      -38.39   -156.20                                   
REMARK 500    ARG A  30       79.60    -68.86                                   
REMARK 500    PHE A  31      -65.38    170.01                                   
REMARK 500    PHE A  34      -32.53    -36.03                                   
REMARK 500    ASN A  37       35.64    -75.08                                   
REMARK 500    GLU A  43       24.79     15.63                                   
REMARK 500    GLU A  53       16.95     58.73                                   
REMARK 500    TYR A  57      145.22     66.65                                   
REMARK 500    ARG A  58      -74.43   -177.03                                   
REMARK 500    ASN A  59      -91.45     43.26                                   
REMARK 500    ILE A  60      -81.37     27.51                                   
REMARK 500    ASP A  62       66.82    -67.42                                   
REMARK 500    ALA A  65      -53.20     71.67                                   
REMARK 500    THR A  69       73.60     45.58                                   
REMARK 500    LEU A  70      100.99    -48.26                                   
REMARK 500    LYS A  71     -168.39   -163.99                                   
REMARK 500    GLU A  72      139.13    -34.96                                   
REMARK 500    ALA A 104      149.02   -173.97                                   
REMARK 500    LEU A 113      139.56    -36.17                                   
REMARK 500    LYS A 114     -168.96    -73.52                                   
REMARK 500    THR A 122       83.05     54.91                                   
REMARK 500    ASP A 123      -97.61     63.03                                   
REMARK 500    LEU A 124      159.76    -45.39                                   
REMARK 500    HIS A 130       93.70   -168.71                                   
REMARK 500    TYR A 131      150.27    -46.98                                   
REMARK 500    LYS A 136      -52.88     31.95                                   
REMARK 500    TYR A 138       29.98    -73.77                                   
REMARK 500    VAL A 141     -124.51    -76.03                                   
REMARK 500    THR A 142      -53.40     -4.44                                   
REMARK 500    HIS A 148     -160.97   -126.89                                   
REMARK 500    CYS A 162       85.16   -157.59                                   
REMARK 500    LEU A 186      -30.04   -132.46                                   
REMARK 500    LYS A 188      108.83     38.94                                   
REMARK 500    ALA A 190      -35.51    -37.01                                   
REMARK 500    SER A 191      106.81    175.34                                   
REMARK 500    ILE A 194       -7.38   -150.87                                   
REMARK 500    GLU A 195     -175.83    -49.40                                   
REMARK 500    LEU A 199       91.93     75.14                                   
REMARK 500    LEU A 202      135.50   -175.62                                   
REMARK 500    SER A 205       52.85     31.47                                   
REMARK 500    PRO A 207     -127.29   -137.52                                   
REMARK 500    LYS A 209       11.58     51.74                                   
REMARK 500    GLU A 212     -148.11     57.69                                   
REMARK 500    GLU A 213       94.07     75.70                                   
REMARK 500    LYS A 214      -66.61    -14.38                                   
REMARK 500    TYR A 229     -137.41     60.67                                   
REMARK 500    ASP A 230       38.22    179.43                                   
REMARK 500    GLU A 234     -152.72    -72.47                                   
REMARK 500    ASP A 235      -40.39     69.76                                   
REMARK 500    SER A 238       42.65   -109.35                                   
REMARK 500    GLU A 242       92.29   -162.07                                   
REMARK 500    GLN A 264      -39.76    -35.06                                   
REMARK 500    ASP A 265      104.81    -52.54                                   
REMARK 500    ASP A 266      -28.44     64.66                                   
REMARK 500    GLU A 279       31.71    -80.48                                   
REMARK 500    ASN A 282       84.26     62.46                                   
REMARK 500    ALA A 302      -57.19     79.98                                   
REMARK 500    THR A 303       35.24   -142.62                                   
REMARK 500    GLN A 306      177.77    -51.31                                   
REMARK 500    PHE A 310      -70.49    -54.04                                   
REMARK 500    ASN A 312      -40.85   -161.96                                   
REMARK 500    GLU A 326      -84.61   -121.76                                   
REMARK 500    LEU A 327      142.82    -33.66                                   
REMARK 500    LYS A 328      -69.70    -20.77                                   
REMARK 500    LEU A 329      -42.93     69.18                                   
REMARK 500    ARG A 330      -58.86     68.70                                   
REMARK 500    LYS A 331      -37.07    -30.68                                   
REMARK 500    SER A 340      106.20    -59.95                                   
REMARK 500    LYS A 357      -83.42     63.55                                   
REMARK 500    LEU A 363      101.55    -58.68                                   
REMARK 500    THR A 373       84.19   -163.44                                   
REMARK 500    SER A 375     -123.49   -129.62                                   
REMARK 500    ARG A 376       81.96    -60.58                                   
REMARK 500    SER A 400     -134.10     68.23                                   
REMARK 500    VAL A 401      126.48     81.07                                   
REMARK 500    LYS A 410      101.17    -56.42                                   
REMARK 500    VAL A 411     -109.98     33.94                                   
REMARK 500    ASP A 412       48.35    -66.85                                   
REMARK 500    GLN A 413      -91.03   -104.06                                   
REMARK 500    MET A 428      170.86    -56.62                                   
REMARK 500    ALA A 461       27.21    -75.63                                   
REMARK 500    ASN A 464     -105.78    -95.51                                   
REMARK 500    LEU B   6     -136.34   -104.32                                   
REMARK 500    LYS B  10      177.61     60.57                                   
REMARK 500    TRP B  13     -172.78    -63.69                                   
REMARK 500    ASP B  14      -73.75     71.24                                   
REMARK 500    TYR B  16      -96.75    -59.39                                   
REMARK 500    ASP B  17     -117.24     43.24                                   
REMARK 500    ASP B  18       -8.86     61.71                                   
REMARK 500    LYS B  19      -25.09     67.54                                   
REMARK 500    GLN B  20      -71.28    -92.00                                   
REMARK 500    VAL B  24        5.39    -64.40                                   
REMARK 500    PHE B  25      -38.69   -156.85                                   
REMARK 500    ARG B  30       80.30    -68.25                                   
REMARK 500    PHE B  31      -64.81    169.38                                   
REMARK 500    PHE B  34      -31.38    -35.52                                   
REMARK 500    ASN B  37       36.69    -76.98                                   
REMARK 500    GLU B  43       26.35     15.06                                   
REMARK 500    TYR B  57      144.11     67.00                                   
REMARK 500    ARG B  58      -74.19   -175.45                                   
REMARK 500    ASN B  59      -90.47     42.82                                   
REMARK 500    ILE B  60      -81.52     26.58                                   
REMARK 500    ASP B  62       65.84    -66.76                                   
REMARK 500    ALA B  65      -52.96     71.40                                   
REMARK 500    THR B  69       74.56     45.26                                   
REMARK 500    LEU B  70      101.80    -49.30                                   
REMARK 500    LYS B  71     -168.07   -164.63                                   
REMARK 500    GLU B  72      139.40    -35.19                                   
REMARK 500    ALA B 104      148.40   -171.84                                   
REMARK 500    LEU B 113      138.93    -36.12                                   
REMARK 500    THR B 122       82.58     55.87                                   
REMARK 500    ASP B 123      -96.46     63.10                                   
REMARK 500    LEU B 124      158.26    -45.97                                   
REMARK 500    HIS B 130       92.12   -169.54                                   
REMARK 500    LYS B 136      -53.21     33.04                                   
REMARK 500    TYR B 138       28.67    -73.68                                   
REMARK 500    VAL B 141     -126.11    -76.37                                   
REMARK 500    THR B 142      -53.39     -3.10                                   
REMARK 500    HIS B 148     -161.97   -128.46                                   
REMARK 500    CYS B 162       85.21   -155.75                                   
REMARK 500    ASP B 167       -6.01    -58.44                                   
REMARK 500    LYS B 188      108.61     38.97                                   
REMARK 500    ALA B 190      -36.23    -36.07                                   
REMARK 500    SER B 191      106.95    176.45                                   
REMARK 500    ILE B 194       -8.46   -151.37                                   
REMARK 500    GLU B 195     -174.17    -48.94                                   
REMARK 500    LEU B 199       92.78     75.48                                   
REMARK 500    LEU B 202      135.32   -176.01                                   
REMARK 500    SER B 205       53.58     32.42                                   
REMARK 500    PRO B 207     -126.01   -133.44                                   
REMARK 500    LYS B 209       11.34     52.07                                   
REMARK 500    GLU B 212     -148.04     57.78                                   
REMARK 500    GLU B 213       95.28     75.33                                   
REMARK 500    LYS B 214      -66.80    -15.47                                   
REMARK 500    TYR B 229     -138.90     58.60                                   
REMARK 500    ASP B 230       37.43   -178.61                                   
REMARK 500    GLU B 234     -152.55    -70.61                                   
REMARK 500    ASP B 235      -40.56     69.54                                   
REMARK 500    SER B 238       42.73   -109.00                                   
REMARK 500    GLU B 242       95.31   -162.50                                   
REMARK 500    ASP B 265      105.61    -50.67                                   
REMARK 500    ASP B 266      -27.94     62.80                                   
REMARK 500    GLU B 279       32.85    -81.76                                   
REMARK 500    ASN B 282       83.74     62.67                                   
REMARK 500    ALA B 302      -57.40     80.64                                   
REMARK 500    THR B 303       34.32   -142.74                                   
REMARK 500    GLN B 306      178.41    -50.42                                   
REMARK 500    PHE B 310      -71.09    -53.33                                   
REMARK 500    ASN B 312      -39.92   -160.25                                   
REMARK 500    GLU B 326      -85.10   -121.45                                   
REMARK 500    LEU B 327      143.30    -33.60                                   
REMARK 500    LYS B 328      -68.51    -21.49                                   
REMARK 500    LEU B 329      -41.98     67.72                                   
REMARK 500    ARG B 330      -58.16     67.66                                   
REMARK 500    LYS B 331      -36.21    -30.85                                   
REMARK 500    LYS B 357      -85.09     64.03                                   
REMARK 500    LEU B 363      102.32    -58.36                                   
REMARK 500    THR B 373       84.90   -162.88                                   
REMARK 500    SER B 375     -124.52   -128.41                                   
REMARK 500    ARG B 376       82.16    -60.35                                   
REMARK 500    LEU B 396       20.03    -72.15                                   
REMARK 500    SER B 400     -133.67     68.23                                   
REMARK 500    VAL B 401      125.71     80.48                                   
REMARK 500    LYS B 410      103.95    -54.49                                   
REMARK 500    VAL B 411     -109.30     31.41                                   
REMARK 500    ASP B 412       47.60    -66.60                                   
REMARK 500    GLN B 413      -91.10   -103.29                                   
REMARK 500    MET B 428      170.74    -55.30                                   
REMARK 500    ALA B 461       26.74    -75.66                                   
REMARK 500    ASN B 464      -99.32   -144.40                                   
REMARK 500    LYS C  10      177.32     51.77                                   
REMARK 500    TRP C  13     -173.29    -65.31                                   
REMARK 500    ASP C  14      -75.03     72.16                                   
REMARK 500    TYR C  16      -96.42    -59.43                                   
REMARK 500    ASP C  17     -116.85     43.34                                   
REMARK 500    ASP C  18       -9.04     61.64                                   
REMARK 500    LYS C  19      -25.99     67.62                                   
REMARK 500    GLN C  20      -71.28    -90.85                                   
REMARK 500    VAL C  24        4.80    -64.99                                   
REMARK 500    PHE C  25      -39.29   -155.30                                   
REMARK 500    ARG C  30       79.00    -68.04                                   
REMARK 500    PHE C  31      -64.84    170.36                                   
REMARK 500    PHE C  34      -32.49    -35.36                                   
REMARK 500    ASN C  37       35.44    -75.66                                   
REMARK 500    GLU C  43       26.64     15.10                                   
REMARK 500    GLU C  53       16.57     59.12                                   
REMARK 500    TYR C  57      144.25     66.36                                   
REMARK 500    ARG C  58      -73.54   -176.18                                   
REMARK 500    ASN C  59      -90.03     41.99                                   
REMARK 500    ILE C  60      -80.67     26.40                                   
REMARK 500    ASP C  62       66.94    -68.07                                   
REMARK 500    ALA C  65      -53.12     71.73                                   
REMARK 500    THR C  69       74.40     45.11                                   
REMARK 500    LEU C  70      100.80    -48.94                                   
REMARK 500    LYS C  71     -168.15   -163.97                                   
REMARK 500    GLU C  72      139.87    -35.46                                   
REMARK 500    ALA C 104      148.36   -172.61                                   
REMARK 500    LEU C 113      140.19    -38.61                                   
REMARK 500    THR C 122       82.07     55.46                                   
REMARK 500    ASP C 123      -98.23     63.83                                   
REMARK 500    LEU C 124      160.96    -44.37                                   
REMARK 500    HIS C 130       93.59   -169.03                                   
REMARK 500    TYR C 131      150.36    -47.31                                   
REMARK 500    LYS C 136      -53.63     33.14                                   
REMARK 500    TYR C 138       30.05    -72.75                                   
REMARK 500    VAL C 141     -125.68    -75.71                                   
REMARK 500    THR C 142      -52.83     -3.31                                   
REMARK 500    HIS C 148     -162.71   -126.74                                   
REMARK 500    CYS C 162       85.23   -155.83                                   
REMARK 500    ASP C 167       -6.26    -59.52                                   
REMARK 500    LYS C 188      107.62     39.11                                   
REMARK 500    ALA C 190      -35.45    -37.34                                   
REMARK 500    SER C 191      107.03    175.68                                   
REMARK 500    ILE C 194       -7.25   -152.06                                   
REMARK 500    GLU C 195     -174.00    -49.02                                   
REMARK 500    LEU C 199       92.67     73.57                                   
REMARK 500    LEU C 202      134.89   -173.68                                   
REMARK 500    SER C 205       52.82     32.14                                   
REMARK 500    PRO C 207     -128.05   -138.69                                   
REMARK 500    LYS C 209       11.41     51.74                                   
REMARK 500    GLU C 212     -148.49     57.29                                   
REMARK 500    GLU C 213       95.20     75.88                                   
REMARK 500    LYS C 214      -67.31    -15.97                                   
REMARK 500    TYR C 229     -137.92     60.17                                   
REMARK 500    ASP C 230       37.04   -179.98                                   
REMARK 500    GLU C 234     -151.29    -72.10                                   
REMARK 500    ASP C 235      -39.96     68.11                                   
REMARK 500    SER C 238       43.55   -108.94                                   
REMARK 500    GLU C 242       95.43   -162.89                                   
REMARK 500    ASP C 265      105.56    -52.57                                   
REMARK 500    ASP C 266      -27.89     63.25                                   
REMARK 500    GLU C 279       32.06    -81.61                                   
REMARK 500    ASN C 282       84.27     62.95                                   
REMARK 500    ASP C 293     -162.87   -129.33                                   
REMARK 500    ALA C 302      -57.27     80.97                                   
REMARK 500    THR C 303       34.79   -142.86                                   
REMARK 500    GLN C 306      178.39    -50.81                                   
REMARK 500    PHE C 310      -71.49    -53.27                                   
REMARK 500    ASN C 312      -41.12   -161.16                                   
REMARK 500    GLU C 326      -84.89   -121.42                                   
REMARK 500    LEU C 327      143.09    -33.37                                   
REMARK 500    LYS C 328      -68.90    -21.23                                   
REMARK 500    LEU C 329      -42.26     68.27                                   
REMARK 500    ARG C 330      -58.90     68.12                                   
REMARK 500    LYS C 331      -37.06    -30.42                                   
REMARK 500    SER C 340      106.98    -59.84                                   
REMARK 500    LYS C 357      -84.12     64.23                                   
REMARK 500    LEU C 363      102.92    -59.54                                   
REMARK 500    THR C 373       84.98   -162.51                                   
REMARK 500    SER C 375     -123.54   -129.32                                   
REMARK 500    ARG C 376       81.39    -61.28                                   
REMARK 500    LYS C 378       17.42     59.30                                   
REMARK 500    SER C 400     -132.00     68.01                                   
REMARK 500    VAL C 401      125.98     79.07                                   
REMARK 500    LYS C 410      102.56    -54.53                                   
REMARK 500    VAL C 411     -109.33     32.14                                   
REMARK 500    ASP C 412       46.73    -66.27                                   
REMARK 500    GLN C 413      -90.71   -102.43                                   
REMARK 500    MET C 428      171.16    -55.92                                   
REMARK 500    ALA C 461       27.27    -75.81                                   
REMARK 500    LYS D  10      154.85     53.63                                   
REMARK 500    ALA D  12      -41.88    -23.25                                   
REMARK 500    TRP D  13     -172.08    -64.13                                   
REMARK 500    ASP D  14      -74.58     71.51                                   
REMARK 500    TYR D  16      -98.19    -58.83                                   
REMARK 500    ASP D  17     -117.00     44.93                                   
REMARK 500    ASP D  18       -9.06     61.34                                   
REMARK 500    LYS D  19      -25.99     67.85                                   
REMARK 500    GLN D  20      -72.28    -91.00                                   
REMARK 500    VAL D  24        5.28    -64.87                                   
REMARK 500    PHE D  25      -39.12   -155.76                                   
REMARK 500    ARG D  30       79.82    -68.26                                   
REMARK 500    PHE D  31      -64.94    169.71                                   
REMARK 500    PHE D  34      -32.00    -35.06                                   
REMARK 500    ASN D  37       35.98    -74.69                                   
REMARK 500    CYS D  38      -40.36   -130.48                                   
REMARK 500    GLU D  43       26.25     15.14                                   
REMARK 500    GLU D  53       16.16     59.20                                   
REMARK 500    TYR D  57      144.51     66.07                                   
REMARK 500    ARG D  58      -74.43   -176.30                                   
REMARK 500    ASN D  59      -90.34     43.05                                   
REMARK 500    ILE D  60      -80.76     26.43                                   
REMARK 500    ASP D  62       66.61    -66.93                                   
REMARK 500    ALA D  65      -53.19     71.27                                   
REMARK 500    THR D  69       74.73     45.64                                   
REMARK 500    LEU D  70      101.60    -49.17                                   
REMARK 500    LYS D  71     -168.17   -164.28                                   
REMARK 500    GLU D  72      140.18    -35.44                                   
REMARK 500    ALA D 104      147.81   -173.13                                   
REMARK 500    LEU D 113      138.54    -36.20                                   
REMARK 500    LYS D 114     -169.71    -74.58                                   
REMARK 500    THR D 122       83.47     54.49                                   
REMARK 500    ASP D 123      -97.31     62.43                                   
REMARK 500    LEU D 124      159.27    -45.02                                   
REMARK 500    HIS D 130       94.71   -169.91                                   
REMARK 500    LYS D 136      -53.32     32.44                                   
REMARK 500    TYR D 138       30.90    -74.84                                   
REMARK 500    VAL D 141     -123.99    -76.19                                   
REMARK 500    THR D 142      -51.19     -4.91                                   
REMARK 500    HIS D 148     -161.49   -127.24                                   
REMARK 500    CYS D 162       84.29   -156.76                                   
REMARK 500    ASP D 167       -5.83    -59.51                                   
REMARK 500    LYS D 188      108.74     39.56                                   
REMARK 500    ALA D 190      -36.05    -36.99                                   
REMARK 500    SER D 191      107.00    176.67                                   
REMARK 500    ILE D 194       -7.40   -152.35                                   
REMARK 500    GLU D 195     -175.35    -49.19                                   
REMARK 500    LEU D 199       93.85     73.34                                   
REMARK 500    LEU D 202      134.63   -177.03                                   
REMARK 500    SER D 205       52.88     32.61                                   
REMARK 500    PRO D 207     -126.06   -133.34                                   
REMARK 500    LYS D 209       10.92     52.16                                   
REMARK 500    GLU D 212     -148.59     57.55                                   
REMARK 500    GLU D 213       95.20     75.54                                   
REMARK 500    LYS D 214      -67.27    -15.65                                   
REMARK 500    TYR D 229     -138.27     60.22                                   
REMARK 500    ASP D 230       37.19   -179.85                                   
REMARK 500    GLU D 234     -153.52    -72.95                                   
REMARK 500    ASP D 235      -40.46     70.41                                   
REMARK 500    SER D 238       42.03   -109.68                                   
REMARK 500    GLU D 242       94.02   -161.66                                   
REMARK 500    ASP D 265      105.73    -52.39                                   
REMARK 500    ASP D 266      -27.10     63.06                                   
REMARK 500    GLU D 279       31.62    -80.37                                   
REMARK 500    ASN D 282       84.29     62.74                                   
REMARK 500    ASP D 293     -161.88   -129.66                                   
REMARK 500    ALA D 302      -58.04     79.99                                   
REMARK 500    THR D 303       35.19   -143.03                                   
REMARK 500    GLN D 306      178.36    -50.81                                   
REMARK 500    PHE D 310      -70.69    -53.67                                   
REMARK 500    ASN D 312      -41.27   -161.16                                   
REMARK 500    GLU D 326      -85.93   -121.62                                   
REMARK 500    LEU D 327      143.05    -32.67                                   
REMARK 500    LYS D 328      -69.37    -21.10                                   
REMARK 500    LEU D 329      -42.48     68.82                                   
REMARK 500    ARG D 330      -57.80     67.87                                   
REMARK 500    LYS D 331      -35.11    -31.93                                   
REMARK 500    SER D 340      106.63    -59.36                                   
REMARK 500    LYS D 357      -83.56     64.19                                   
REMARK 500    THR D 373       84.58   -163.01                                   
REMARK 500    SER D 375     -123.76   -129.27                                   
REMARK 500    ARG D 376       82.81    -60.39                                   
REMARK 500    SER D 400     -133.75     67.96                                   
REMARK 500    VAL D 401      126.09     80.04                                   
REMARK 500    LYS D 410      103.02    -55.28                                   
REMARK 500    VAL D 411     -109.24     32.42                                   
REMARK 500    ASP D 412       47.15    -67.23                                   
REMARK 500    GLN D 413      -91.24   -102.14                                   
REMARK 500    MET D 428      170.11    -56.31                                   
REMARK 500    ALA D 461       26.66    -75.02                                   
REMARK 500    LEU E   6      140.69    -39.36                                   
REMARK 500    TYR E   9       51.41    -96.75                                   
REMARK 500    LYS E  10     -134.65     24.70                                   
REMARK 500    TRP E  13     -173.00    -64.17                                   
REMARK 500    ASP E  14      -74.79     71.44                                   
REMARK 500    TYR E  16      -97.59    -59.69                                   
REMARK 500    ASP E  17     -116.09     44.53                                   
REMARK 500    ASP E  18       -8.74     60.36                                   
REMARK 500    LYS E  19      -25.18     67.68                                   
REMARK 500    GLN E  20      -71.24    -91.96                                   
REMARK 500    VAL E  24        4.84    -64.74                                   
REMARK 500    PHE E  25      -39.16   -156.03                                   
REMARK 500    ARG E  30       79.68    -68.77                                   
REMARK 500    PHE E  31      -64.75    169.94                                   
REMARK 500    PHE E  34      -31.84    -34.69                                   
REMARK 500    ASN E  37       36.07    -76.22                                   
REMARK 500    GLU E  43       26.33     15.18                                   
REMARK 500    GLU E  53       15.75     59.14                                   
REMARK 500    TYR E  57      145.23     66.15                                   
REMARK 500    ARG E  58      -74.67   -176.45                                   
REMARK 500    ASN E  59      -89.17     43.25                                   
REMARK 500    ILE E  60      -81.05     25.46                                   
REMARK 500    ASP E  62       66.84    -67.11                                   
REMARK 500    ALA E  65      -54.04     71.96                                   
REMARK 500    THR E  69       74.36     45.77                                   
REMARK 500    LEU E  70      101.76    -48.90                                   
REMARK 500    LYS E  71     -168.65   -165.02                                   
REMARK 500    GLU E  72      140.28    -34.49                                   
REMARK 500    ALA E 104      149.76   -170.46                                   
REMARK 500    LEU E 113      137.75    -37.12                                   
REMARK 500    LYS E 114     -169.61    -71.26                                   
REMARK 500    THR E 122       82.47     55.31                                   
REMARK 500    ASP E 123      -95.50     63.60                                   
REMARK 500    LEU E 124      157.98    -46.33                                   
REMARK 500    HIS E 130       94.15   -169.97                                   
REMARK 500    LYS E 136      -53.61     33.18                                   
REMARK 500    TYR E 138       29.24    -72.95                                   
REMARK 500    VAL E 141     -126.23    -75.90                                   
REMARK 500    THR E 142      -53.82     -2.26                                   
REMARK 500    HIS E 148     -161.44   -127.29                                   
REMARK 500    CYS E 162       86.18   -158.49                                   
REMARK 500    ASP E 167       -5.81    -59.94                                   
REMARK 500    LYS E 188      107.70     38.41                                   
REMARK 500    ALA E 190      -35.38    -35.80                                   
REMARK 500    SER E 191      107.09    175.64                                   
REMARK 500    ILE E 194       -9.01   -151.05                                   
REMARK 500    GLU E 195     -175.33    -48.43                                   
REMARK 500    LEU E 199       94.25     74.58                                   
REMARK 500    LEU E 202      134.02   -176.04                                   
REMARK 500    SER E 205       52.62     31.98                                   
REMARK 500    PRO E 207     -126.63   -136.04                                   
REMARK 500    LYS E 209       11.16     51.19                                   
REMARK 500    GLU E 212     -148.98     57.32                                   
REMARK 500    GLU E 213       95.01     76.31                                   
REMARK 500    LYS E 214      -66.62    -15.87                                   
REMARK 500    TYR E 229     -138.16     59.99                                   
REMARK 500    ASP E 230       37.26    179.86                                   
REMARK 500    GLU E 234     -152.70    -71.69                                   
REMARK 500    ASP E 235      -41.99     70.62                                   
REMARK 500    SER E 238       41.48   -109.71                                   
REMARK 500    GLU E 242       95.10   -161.77                                   
REMARK 500    GLN E 264      -39.91    -35.82                                   
REMARK 500    ASP E 265      105.61    -52.03                                   
REMARK 500    ASP E 266      -29.26     63.59                                   
REMARK 500    GLU E 279       32.30    -79.63                                   
REMARK 500    ASN E 282       83.53     62.71                                   
REMARK 500    SER E 299       32.98     70.26                                   
REMARK 500    ALA E 302      -56.49     80.39                                   
REMARK 500    THR E 303       34.86   -143.56                                   
REMARK 500    GLN E 306      178.28    -51.46                                   
REMARK 500    PHE E 310      -71.35    -53.44                                   
REMARK 500    ASN E 312      -41.17   -159.71                                   
REMARK 500    GLU E 326      -85.44   -121.49                                   
REMARK 500    LEU E 327      143.34    -32.92                                   
REMARK 500    LYS E 328      -69.43    -21.57                                   
REMARK 500    LEU E 329      -42.41     68.62                                   
REMARK 500    ARG E 330      -58.70     68.42                                   
REMARK 500    LYS E 331      -35.58    -30.62                                   
REMARK 500    LYS E 357      -82.44     63.91                                   
REMARK 500    LEU E 363      102.01    -59.75                                   
REMARK 500    THR E 373       83.21   -163.70                                   
REMARK 500    SER E 375     -124.80   -128.71                                   
REMARK 500    ARG E 376       81.67    -59.38                                   
REMARK 500    SER E 400     -133.74     69.38                                   
REMARK 500    VAL E 401      126.89     79.77                                   
REMARK 500    LYS E 410      102.54    -53.77                                   
REMARK 500    VAL E 411     -109.19     32.92                                   
REMARK 500    ASP E 412       47.20    -67.14                                   
REMARK 500    GLN E 413      -90.26   -102.49                                   
REMARK 500    MET E 428      170.48    -56.47                                   
REMARK 500    ALA E 461       27.12    -73.55                                   
REMARK 500    ASN E 464      -99.24    -50.31                                   
REMARK 500    TRP F  13     -173.75    -65.83                                   
REMARK 500    ASP F  14      -75.38     72.48                                   
REMARK 500    TYR F  16      -97.82    -58.78                                   
REMARK 500    ASP F  17     -116.08     44.24                                   
REMARK 500    ASP F  18       -8.96     60.81                                   
REMARK 500    LYS F  19      -25.71     67.93                                   
REMARK 500    GLN F  20      -71.98    -91.28                                   
REMARK 500    VAL F  24        4.79    -65.13                                   
REMARK 500    PHE F  25      -38.77   -156.16                                   
REMARK 500    ARG F  30       80.63    -67.50                                   
REMARK 500    PHE F  31      -65.53    169.63                                   
REMARK 500    PHE F  34      -32.07    -35.42                                   
REMARK 500    ASN F  37       35.74    -75.41                                   
REMARK 500    GLU F  43       27.71     14.03                                   
REMARK 500    GLU F  53       16.95     59.24                                   
REMARK 500    TYR F  57      144.59     68.06                                   
REMARK 500    ARG F  58      -73.74   -176.63                                   
REMARK 500    ASN F  59      -90.39     42.68                                   
REMARK 500    ILE F  60      -81.79     26.24                                   
REMARK 500    ASP F  62       66.94    -67.90                                   
REMARK 500    ALA F  65      -52.70     70.61                                   
REMARK 500    THR F  69       74.05     45.42                                   
REMARK 500    LEU F  70      101.16    -48.39                                   
REMARK 500    LYS F  71     -169.05   -164.39                                   
REMARK 500    GLU F  72      140.09    -34.27                                   
REMARK 500    ALA F 104      148.60   -172.97                                   
REMARK 500    LEU F 113      138.45    -35.46                                   
REMARK 500    LYS F 114     -169.61    -72.89                                   
REMARK 500    THR F 122       83.08     55.01                                   
REMARK 500    ASP F 123      -97.27     63.03                                   
REMARK 500    LEU F 124      158.69    -45.46                                   
REMARK 500    HIS F 130       94.00   -167.64                                   
REMARK 500    LYS F 136      -53.07     31.71                                   
REMARK 500    TYR F 138       30.47    -74.94                                   
REMARK 500    VAL F 141     -125.65    -76.32                                   
REMARK 500    THR F 142      -54.57     -3.98                                   
REMARK 500    HIS F 148     -161.90   -128.65                                   
REMARK 500    CYS F 162       86.71   -155.13                                   
REMARK 500    ASP F 167       -6.66    -59.38                                   
REMARK 500    LYS F 188      107.97     39.21                                   
REMARK 500    ALA F 190      -35.76    -36.95                                   
REMARK 500    SER F 191      108.33    176.41                                   
REMARK 500    ILE F 194       -7.54   -152.27                                   
REMARK 500    GLU F 195     -174.23    -48.77                                   
REMARK 500    LEU F 199       93.07     74.64                                   
REMARK 500    LEU F 202      134.84   -173.94                                   
REMARK 500    SER F 205       52.58     30.89                                   
REMARK 500    PRO F 207     -127.86   -136.48                                   
REMARK 500    LYS F 209       10.83     52.32                                   
REMARK 500    GLU F 212     -148.51     57.63                                   
REMARK 500    GLU F 213       95.45     75.43                                   
REMARK 500    LYS F 214      -67.04    -15.96                                   
REMARK 500    TYR F 229     -137.31     59.64                                   
REMARK 500    ASP F 230       36.47    179.80                                   
REMARK 500    GLU F 234     -152.96    -71.99                                   
REMARK 500    ASP F 235      -39.02     69.14                                   
REMARK 500    SER F 238       43.81   -107.88                                   
REMARK 500    GLU F 242       95.17   -162.27                                   
REMARK 500    GLN F 264      -39.85    -35.90                                   
REMARK 500    ASP F 265      105.73    -52.31                                   
REMARK 500    ASP F 266      -27.16     62.97                                   
REMARK 500    GLU F 279       32.43    -81.59                                   
REMARK 500    ASN F 282       83.74     62.91                                   
REMARK 500    ASP F 293     -161.94   -129.96                                   
REMARK 500    SER F 299       33.93     70.00                                   
REMARK 500    ALA F 302      -57.12     79.95                                   
REMARK 500    THR F 303       35.10   -143.27                                   
REMARK 500    GLN F 306      178.64    -50.95                                   
REMARK 500    PHE F 310      -71.24    -54.07                                   
REMARK 500    ASN F 312      -39.99   -162.49                                   
REMARK 500    GLU F 326      -85.29   -121.57                                   
REMARK 500    LEU F 327      143.24    -33.50                                   
REMARK 500    LYS F 328      -69.16    -20.97                                   
REMARK 500    LEU F 329      -42.36     68.33                                   
REMARK 500    ARG F 330      -59.07     68.25                                   
REMARK 500    LYS F 331      -35.87    -30.56                                   
REMARK 500    LYS F 357      -82.30     63.66                                   
REMARK 500    THR F 373       84.00   -162.36                                   
REMARK 500    SER F 375     -124.35   -128.22                                   
REMARK 500    ARG F 376       81.86    -60.18                                   
REMARK 500    SER F 400     -133.66     68.06                                   
REMARK 500    VAL F 401      126.14     80.45                                   
REMARK 500    LYS F 410      103.46    -55.71                                   
REMARK 500    VAL F 411     -110.57     31.91                                   
REMARK 500    ASP F 412       47.42    -66.33                                   
REMARK 500    GLN F 413      -91.13   -102.18                                   
REMARK 500    MET F 428      171.06    -56.88                                   
REMARK 500    ALA F 461       26.79    -75.55                                   
REMARK 500    ASN F 464      -85.47   -113.08                                   
REMARK 500    TRP G  13     -173.06    -65.61                                   
REMARK 500    ASP G  14      -75.38     72.73                                   
REMARK 500    TYR G  16      -97.28    -60.25                                   
REMARK 500    ASP G  17     -116.53     44.33                                   
REMARK 500    ASP G  18       -8.86     61.28                                   
REMARK 500    LYS G  19      -25.23     67.49                                   
REMARK 500    GLN G  20      -72.00    -91.78                                   
REMARK 500    VAL G  24        6.59    -65.12                                   
REMARK 500    PHE G  25      -37.61   -157.41                                   
REMARK 500    ARG G  30       79.66    -67.88                                   
REMARK 500    PHE G  31      -64.74    170.19                                   
REMARK 500    PHE G  34      -32.25    -35.58                                   
REMARK 500    ASN G  37       34.33    -73.78                                   
REMARK 500    GLU G  43       26.90     15.18                                   
REMARK 500    GLU G  53       16.12     59.11                                   
REMARK 500    TYR G  57      144.73     66.81                                   
REMARK 500    ARG G  58      -73.79   -176.67                                   
REMARK 500    ASN G  59      -90.99     42.27                                   
REMARK 500    ILE G  60      -81.29     27.16                                   
REMARK 500    ASP G  62       66.77    -67.51                                   
REMARK 500    ALA G  65      -52.91     71.28                                   
REMARK 500    THR G  69       74.04     45.13                                   
REMARK 500    LEU G  70      101.32    -48.39                                   
REMARK 500    LYS G  71     -168.25   -164.63                                   
REMARK 500    GLU G  72      139.85    -35.34                                   
REMARK 500    ALA G 104      147.83   -172.86                                   
REMARK 500    LEU G 113      139.95    -37.80                                   
REMARK 500    LYS G 114     -169.02    -73.71                                   
REMARK 500    THR G 122       83.72     54.36                                   
REMARK 500    ASP G 123      -97.36     62.21                                   
REMARK 500    LEU G 124      158.89    -45.36                                   
REMARK 500    HIS G 130       94.83   -168.41                                   
REMARK 500    LYS G 136      -52.68     32.50                                   
REMARK 500    TYR G 138       30.75    -73.84                                   
REMARK 500    VAL G 141     -125.47    -75.50                                   
REMARK 500    THR G 142      -52.67     -3.29                                   
REMARK 500    HIS G 148     -161.11   -126.57                                   
REMARK 500    CYS G 162       84.73   -156.36                                   
REMARK 500    ASP G 167       -6.14    -59.67                                   
REMARK 500    LYS G 188      108.99     38.98                                   
REMARK 500    ALA G 190      -37.05    -37.30                                   
REMARK 500    SER G 191      106.88    177.45                                   
REMARK 500    ILE G 194       -7.62   -152.57                                   
REMARK 500    GLU G 195     -174.37    -48.62                                   
REMARK 500    LEU G 199       91.97     76.44                                   
REMARK 500    LEU G 202      134.99   -174.74                                   
REMARK 500    SER G 205       52.10     30.55                                   
REMARK 500    PRO G 207     -126.95   -134.82                                   
REMARK 500    LYS G 209       11.34     52.14                                   
REMARK 500    GLU G 212     -148.89     57.78                                   
REMARK 500    GLU G 213       95.11     76.12                                   
REMARK 500    LYS G 214      -66.64    -15.95                                   
REMARK 500    TYR G 229     -137.96     60.00                                   
REMARK 500    ASP G 230       37.98    179.63                                   
REMARK 500    GLU G 234     -152.40    -72.61                                   
REMARK 500    ASP G 235      -40.11     69.64                                   
REMARK 500    SER G 238       44.31   -109.21                                   
REMARK 500    GLU G 242       92.92   -161.06                                   
REMARK 500    ASP G 265      104.98    -51.49                                   
REMARK 500    ASP G 266      -27.20     63.95                                   
REMARK 500    GLU G 279       31.07    -80.53                                   
REMARK 500    ASN G 282       83.43     62.51                                   
REMARK 500    ILE G 300      176.51    -59.51                                   
REMARK 500    ALA G 302      -57.80     80.71                                   
REMARK 500    THR G 303       35.39   -143.03                                   
REMARK 500    GLN G 306      178.52    -49.94                                   
REMARK 500    PHE G 310      -70.04    -53.58                                   
REMARK 500    ASN G 312      -41.64   -160.97                                   
REMARK 500    GLU G 326      -85.36   -121.21                                   
REMARK 500    LEU G 327      142.87    -32.73                                   
REMARK 500    LYS G 328      -69.40    -21.00                                   
REMARK 500    LEU G 329      -43.11     68.68                                   
REMARK 500    ARG G 330      -58.67     68.75                                   
REMARK 500    LYS G 331      -36.89    -30.55                                   
REMARK 500    SER G 340      107.65    -59.83                                   
REMARK 500    LYS G 357      -83.38     64.22                                   
REMARK 500    LEU G 363      100.47    -58.10                                   
REMARK 500    THR G 373       84.19   -162.96                                   
REMARK 500    SER G 375     -123.89   -128.25                                   
REMARK 500    ARG G 376       82.51    -60.77                                   
REMARK 500    SER G 400     -134.44     69.16                                   
REMARK 500    VAL G 401      126.93     80.46                                   
REMARK 500    LYS G 410      104.65    -55.48                                   
REMARK 500    VAL G 411     -109.84     30.35                                   
REMARK 500    ASP G 412       47.41    -66.08                                   
REMARK 500    GLN G 413      -91.22   -102.88                                   
REMARK 500    ALA G 461       27.14    -75.46                                   
REMARK 500    LEU H   6     -142.41   -102.22                                   
REMARK 500    LYS H   7       87.61   -162.18                                   
REMARK 500    LYS H  10      175.77     56.07                                   
REMARK 500    ASN H  11     -165.96   -114.18                                   
REMARK 500    TRP H  13     -173.46    -64.43                                   
REMARK 500    ASP H  14      -74.40     72.49                                   
REMARK 500    TYR H  16      -97.39    -60.22                                   
REMARK 500    ASP H  17     -116.04     44.53                                   
REMARK 500    ASP H  18       -8.86     60.31                                   
REMARK 500    LYS H  19      -25.58     67.98                                   
REMARK 500    GLN H  20      -71.44    -92.05                                   
REMARK 500    VAL H  24        5.47    -64.53                                   
REMARK 500    PHE H  25      -37.17   -157.00                                   
REMARK 500    ARG H  30       80.92    -69.00                                   
REMARK 500    PHE H  31      -66.02    169.16                                   
REMARK 500    PHE H  34      -32.97    -35.41                                   
REMARK 500    ASN H  37       35.56    -77.07                                   
REMARK 500    GLU H  43       27.81     14.30                                   
REMARK 500    GLU H  53       16.67     59.38                                   
REMARK 500    TYR H  57      145.43     67.49                                   
REMARK 500    ARG H  58      -74.23   -177.30                                   
REMARK 500    ASN H  59      -89.08     42.75                                   
REMARK 500    ILE H  60      -81.92     25.90                                   
REMARK 500    ASP H  62       66.14    -66.56                                   
REMARK 500    ALA H  65      -53.63     71.49                                   
REMARK 500    THR H  69       74.68     44.62                                   
REMARK 500    LEU H  70      101.62    -48.90                                   
REMARK 500    LYS H  71     -168.55   -164.50                                   
REMARK 500    GLU H  72      140.08    -34.67                                   
REMARK 500    ALA H 104      147.82   -171.48                                   
REMARK 500    LEU H 113      137.83    -36.32                                   
REMARK 500    LYS H 114     -169.19    -72.49                                   
REMARK 500    THR H 122       82.04     55.84                                   
REMARK 500    ASP H 123      -95.70     63.51                                   
REMARK 500    LEU H 124      158.39    -46.94                                   
REMARK 500    HIS H 130       92.23   -170.14                                   
REMARK 500    LYS H 136      -54.51     32.36                                   
REMARK 500    TYR H 138       30.89    -73.71                                   
REMARK 500    VAL H 141     -124.85    -76.68                                   
REMARK 500    THR H 142      -53.69     -4.07                                   
REMARK 500    HIS H 148     -162.56   -126.05                                   
REMARK 500    CYS H 162       85.91   -156.64                                   
REMARK 500    ASP H 167       -6.12    -59.59                                   
REMARK 500    LYS H 188      109.14     38.42                                   
REMARK 500    ALA H 190      -35.12    -36.96                                   
REMARK 500    SER H 191      107.42    175.91                                   
REMARK 500    ILE H 194       -7.27   -152.97                                   
REMARK 500    GLU H 195     -174.47    -49.27                                   
REMARK 500    LEU H 199       93.52     75.18                                   
REMARK 500    LEU H 202      133.97   -174.29                                   
REMARK 500    SER H 205       52.94     32.52                                   
REMARK 500    PRO H 207     -129.90   -140.45                                   
REMARK 500    LYS H 209       11.32     51.80                                   
REMARK 500    GLU H 212     -148.63     57.91                                   
REMARK 500    GLU H 213       95.46     76.15                                   
REMARK 500    LYS H 214      -67.31    -15.79                                   
REMARK 500    TYR H 229     -139.48     59.53                                   
REMARK 500    ASP H 230       37.16   -178.22                                   
REMARK 500    GLU H 234     -153.34    -72.38                                   
REMARK 500    ASP H 235      -40.15     70.12                                   
REMARK 500    SER H 238       42.63   -107.32                                   
REMARK 500    GLU H 242       95.19   -162.26                                   
REMARK 500    ASP H 265      105.16    -51.89                                   
REMARK 500    ASP H 266      -28.70     64.34                                   
REMARK 500    GLU H 279       32.06    -80.19                                   
REMARK 500    ASN H 282       83.45     62.61                                   
REMARK 500    ALA H 302      -56.56     80.44                                   
REMARK 500    THR H 303       36.03   -144.12                                   
REMARK 500    GLN H 306      178.12    -50.29                                   
REMARK 500    PHE H 310      -70.71    -53.51                                   
REMARK 500    ASN H 312      -40.12   -161.48                                   
REMARK 500    GLU H 326      -84.99   -121.67                                   
REMARK 500    LEU H 327      143.31    -33.29                                   
REMARK 500    LYS H 328      -69.26    -21.29                                   
REMARK 500    LEU H 329      -42.31     68.53                                   
REMARK 500    ARG H 330      -58.26     68.06                                   
REMARK 500    LYS H 331      -36.58    -30.85                                   
REMARK 500    LYS H 357      -82.99     63.40                                   
REMARK 500    THR H 373       84.76   -162.87                                   
REMARK 500    SER H 375     -124.81   -128.54                                   
REMARK 500    ARG H 376       81.81    -59.84                                   
REMARK 500    LYS H 378       18.67     58.92                                   
REMARK 500    SER H 400     -133.04     67.74                                   
REMARK 500    VAL H 401      127.38     79.55                                   
REMARK 500    LYS H 410      103.96    -55.78                                   
REMARK 500    VAL H 411     -109.23     31.40                                   
REMARK 500    ASP H 412       47.49    -67.29                                   
REMARK 500    GLN H 413      -91.15   -102.01                                   
REMARK 500    MET H 428      170.78    -55.91                                   
REMARK 500    ALA H 461       27.40    -74.42                                   
REMARK 500    LEU I   6     -139.12    -66.25                                   
REMARK 500    TRP I  13     -172.25    -64.61                                   
REMARK 500    ASP I  14      -74.87     71.12                                   
REMARK 500    TYR I  16      -97.55    -58.20                                   
REMARK 500    ASP I  17     -117.24     44.44                                   
REMARK 500    ASP I  18       -9.32     61.82                                   
REMARK 500    LYS I  19      -26.02     68.05                                   
REMARK 500    GLN I  20      -71.14    -91.07                                   
REMARK 500    VAL I  24        5.29    -63.05                                   
REMARK 500    PHE I  25      -38.73   -156.58                                   
REMARK 500    ARG I  30       80.20    -68.01                                   
REMARK 500    PHE I  31      -67.10    169.35                                   
REMARK 500    PHE I  34      -32.71    -35.01                                   
REMARK 500    ASN I  37       35.41    -75.25                                   
REMARK 500    GLU I  43       27.34     15.34                                   
REMARK 500    TYR I  57      144.73     66.52                                   
REMARK 500    ARG I  58      -73.69   -176.36                                   
REMARK 500    ASN I  59      -90.11     42.45                                   
REMARK 500    ILE I  60      -81.51     26.32                                   
REMARK 500    ASP I  62       66.38    -67.45                                   
REMARK 500    ALA I  65      -53.23     71.10                                   
REMARK 500    THR I  69       74.59     44.97                                   
REMARK 500    LEU I  70      101.38    -48.75                                   
REMARK 500    LYS I  71     -168.06   -164.55                                   
REMARK 500    GLU I  72      139.39    -35.06                                   
REMARK 500    ALA I 104      148.62   -172.92                                   
REMARK 500    LEU I 113      138.80    -37.18                                   
REMARK 500    THR I 122       82.58     55.06                                   
REMARK 500    ASP I 123      -97.02     63.33                                   
REMARK 500    LEU I 124      158.96    -45.54                                   
REMARK 500    HIS I 130       94.43   -169.01                                   
REMARK 500    LYS I 136      -52.55     32.60                                   
REMARK 500    TYR I 138       30.07    -73.36                                   
REMARK 500    VAL I 141     -125.06    -74.61                                   
REMARK 500    THR I 142      -55.03     -3.86                                   
REMARK 500    HIS I 148     -162.34   -127.70                                   
REMARK 500    CYS I 162       85.79   -156.74                                   
REMARK 500    ASP I 167       -6.17    -59.80                                   
REMARK 500    LEU I 186      -30.38   -131.29                                   
REMARK 500    LYS I 188      108.37     38.92                                   
REMARK 500    ALA I 190      -36.26    -36.56                                   
REMARK 500    SER I 191      107.80    176.55                                   
REMARK 500    ILE I 194       -7.79   -152.54                                   
REMARK 500    GLU I 195     -173.81    -48.72                                   
REMARK 500    LEU I 199       92.42     73.58                                   
REMARK 500    LEU I 202      134.92   -174.70                                   
REMARK 500    SER I 205       51.79     31.81                                   
REMARK 500    PRO I 207     -126.88   -135.40                                   
REMARK 500    LYS I 209       11.27     51.22                                   
REMARK 500    GLU I 212     -148.46     57.88                                   
REMARK 500    GLU I 213       95.17     76.06                                   
REMARK 500    LYS I 214      -67.48    -15.80                                   
REMARK 500    TYR I 229     -138.64     60.09                                   
REMARK 500    ASP I 230       36.85   -179.76                                   
REMARK 500    GLU I 234     -152.58    -71.89                                   
REMARK 500    ASP I 235      -40.82     69.54                                   
REMARK 500    SER I 238       41.89   -108.11                                   
REMARK 500    GLU I 242       93.97   -161.62                                   
REMARK 500    ASP I 265      105.61    -51.14                                   
REMARK 500    ASP I 266      -27.87     63.53                                   
REMARK 500    GLU I 279       31.27    -80.81                                   
REMARK 500    ASN I 282       83.79     62.37                                   
REMARK 500    ALA I 302      -56.71     80.31                                   
REMARK 500    THR I 303       34.50   -142.98                                   
REMARK 500    GLN I 306      178.30    -51.18                                   
REMARK 500    PHE I 310      -70.94    -54.61                                   
REMARK 500    ASN I 312      -39.36   -161.80                                   
REMARK 500    GLU I 326      -85.18   -121.03                                   
REMARK 500    LEU I 327      142.96    -33.38                                   
REMARK 500    LYS I 328      -69.81    -20.76                                   
REMARK 500    LEU I 329      -42.85     68.76                                   
REMARK 500    ARG I 330      -58.67     68.33                                   
REMARK 500    LYS I 331      -36.94    -30.18                                   
REMARK 500    SER I 340      106.48    -57.93                                   
REMARK 500    LYS I 357      -82.05     64.03                                   
REMARK 500    LEU I 363      102.99    -59.02                                   
REMARK 500    THR I 373       84.19   -163.22                                   
REMARK 500    SER I 375     -124.05   -128.42                                   
REMARK 500    ARG I 376       82.38    -60.91                                   
REMARK 500    LEU I 396       20.74    -71.45                                   
REMARK 500    SER I 400     -133.61     68.91                                   
REMARK 500    VAL I 401      125.72     80.37                                   
REMARK 500    LYS I 410      103.15    -55.04                                   
REMARK 500    VAL I 411     -109.27     31.91                                   
REMARK 500    ASP I 412       47.33    -66.97                                   
REMARK 500    GLN I 413      -91.70   -103.09                                   
REMARK 500    MET I 428      170.51    -56.58                                   
REMARK 500    ALA I 461       27.53    -75.89                                   
REMARK 500    ASN I 464     -149.74    -97.30                                   
REMARK 500    LYS J  10      168.81     51.72                                   
REMARK 500    TRP J  13     -171.64    -64.81                                   
REMARK 500    ASP J  14      -74.93     71.14                                   
REMARK 500    TYR J  16      -97.20    -60.38                                   
REMARK 500    ASP J  17     -116.31     44.10                                   
REMARK 500    ASP J  18       -8.57     60.61                                   
REMARK 500    LYS J  19      -24.97     67.29                                   
REMARK 500    GLN J  20      -70.76    -92.14                                   
REMARK 500    VAL J  24        5.57    -64.89                                   
REMARK 500    PHE J  25      -38.26   -156.83                                   
REMARK 500    ARG J  30       78.71    -66.62                                   
REMARK 500    PHE J  31      -64.50    170.67                                   
REMARK 500    PHE J  34      -32.37    -35.86                                   
REMARK 500    ASN J  37       37.24    -76.47                                   
REMARK 500    CYS J  38      -41.92   -130.02                                   
REMARK 500    GLU J  43       28.35     13.69                                   
REMARK 500    GLU J  53       16.18     59.24                                   
REMARK 500    TYR J  57      144.51     66.63                                   
REMARK 500    ARG J  58      -73.16   -176.23                                   
REMARK 500    ASN J  59      -90.47     42.13                                   
REMARK 500    ILE J  60      -82.04     26.66                                   
REMARK 500    ASP J  62       67.43    -67.83                                   
REMARK 500    ALA J  65      -52.27     69.90                                   
REMARK 500    THR J  69       74.46     44.91                                   
REMARK 500    LEU J  70      101.33    -48.95                                   
REMARK 500    LYS J  71     -168.37   -163.85                                   
REMARK 500    GLU J  72      139.72    -35.05                                   
REMARK 500    ALA J 104      148.14   -173.05                                   
REMARK 500    LEU J 113      139.72    -36.80                                   
REMARK 500    LYS J 114     -168.50    -73.32                                   
REMARK 500    THR J 122       83.95     54.01                                   
REMARK 500    ASP J 123      -96.91     62.17                                   
REMARK 500    LEU J 124      158.78    -45.66                                   
REMARK 500    HIS J 130       94.40   -169.80                                   
REMARK 500    LYS J 136      -53.71     32.75                                   
REMARK 500    TYR J 138       29.60    -72.15                                   
REMARK 500    VAL J 141     -126.94    -76.06                                   
REMARK 500    THR J 142      -54.37     -1.82                                   
REMARK 500    HIS J 148     -162.16   -128.20                                   
REMARK 500    CYS J 162       85.62   -155.69                                   
REMARK 500    ASP J 167       -6.34    -59.11                                   
REMARK 500    LYS J 188      108.79     39.04                                   
REMARK 500    ALA J 190      -36.46    -36.47                                   
REMARK 500    SER J 191      107.50    177.17                                   
REMARK 500    ILE J 194       -6.72   -151.75                                   
REMARK 500    GLU J 195     -175.46    -50.26                                   
REMARK 500    LEU J 199       91.99     75.99                                   
REMARK 500    LEU J 202      134.55   -174.68                                   
REMARK 500    SER J 205       52.48     32.13                                   
REMARK 500    PRO J 207     -124.98   -132.74                                   
REMARK 500    LYS J 209       11.26     52.02                                   
REMARK 500    GLU J 212     -148.67     57.80                                   
REMARK 500    GLU J 213       95.42     75.80                                   
REMARK 500    LYS J 214      -67.05    -15.80                                   
REMARK 500    TYR J 229     -137.20     59.18                                   
REMARK 500    ASP J 230       37.60    179.16                                   
REMARK 500    GLU J 234     -152.14    -71.64                                   
REMARK 500    ASP J 235      -41.20     69.25                                   
REMARK 500    SER J 238       41.13   -109.45                                   
REMARK 500    GLU J 242       94.51   -161.92                                   
REMARK 500    ASP J 265      106.91    -52.99                                   
REMARK 500    ASP J 266      -27.47     62.48                                   
REMARK 500    GLU J 279       31.59    -79.33                                   
REMARK 500    ASN J 282       83.64     63.02                                   
REMARK 500    SER J 299       32.35     70.32                                   
REMARK 500    ALA J 302      -57.35     80.25                                   
REMARK 500    THR J 303       35.02   -143.04                                   
REMARK 500    GLN J 306      177.68    -51.63                                   
REMARK 500    LYS J 308      -34.73    -39.99                                   
REMARK 500    PHE J 310      -70.91    -53.69                                   
REMARK 500    ASN J 312      -40.00   -162.27                                   
REMARK 500    GLU J 326      -85.15   -121.29                                   
REMARK 500    LEU J 327      143.39    -33.59                                   
REMARK 500    LYS J 328      -68.96    -21.08                                   
REMARK 500    LEU J 329      -42.96     68.12                                   
REMARK 500    ARG J 330      -58.39     69.07                                   
REMARK 500    LYS J 331      -36.69    -30.58                                   
REMARK 500    LYS J 357      -81.69     63.22                                   
REMARK 500    LEU J 363      101.39    -57.30                                   
REMARK 500    THR J 373       83.92   -163.29                                   
REMARK 500    SER J 375     -124.49   -129.37                                   
REMARK 500    ARG J 376       82.00    -61.00                                   
REMARK 500    SER J 400     -133.69     68.59                                   
REMARK 500    VAL J 401      126.57     80.19                                   
REMARK 500    LYS J 410      103.99    -54.98                                   
REMARK 500    VAL J 411     -108.96     30.86                                   
REMARK 500    ASP J 412       47.59    -66.84                                   
REMARK 500    GLN J 413      -90.48   -102.92                                   
REMARK 500    MET J 428      170.49    -56.80                                   
REMARK 500    ALA J 461       26.34    -75.83                                   
REMARK 500    LEU K   6     -123.76    -87.30                                   
REMARK 500    GLU K   8     -155.43   -171.03                                   
REMARK 500    LYS K  10       43.72    -87.08                                   
REMARK 500    ASN K  11      152.27     56.01                                   
REMARK 500    TRP K  13     -172.77    -64.48                                   
REMARK 500    ASP K  14      -74.24     70.81                                   
REMARK 500    TYR K  16      -96.37    -60.22                                   
REMARK 500    ASP K  17     -116.82     43.36                                   
REMARK 500    ASP K  18       -9.82     61.70                                   
REMARK 500    LYS K  19      -25.53     68.90                                   
REMARK 500    GLN K  20      -71.49    -91.69                                   
REMARK 500    VAL K  24        5.34    -64.28                                   
REMARK 500    PHE K  25      -39.55   -156.20                                   
REMARK 500    ARG K  30       79.11    -67.93                                   
REMARK 500    PHE K  31      -65.52    170.78                                   
REMARK 500    LYS K  32      -70.32    -57.70                                   
REMARK 500    PHE K  34      -33.14    -34.66                                   
REMARK 500    ASN K  37       35.81    -75.72                                   
REMARK 500    GLU K  43       27.65     15.29                                   
REMARK 500    GLU K  53       16.03     59.66                                   
REMARK 500    TYR K  57      144.39     66.91                                   
REMARK 500    ARG K  58      -74.26   -176.26                                   
REMARK 500    ASN K  59      -91.64     43.59                                   
REMARK 500    ILE K  60      -81.01     26.82                                   
REMARK 500    ASP K  62       66.96    -66.90                                   
REMARK 500    ALA K  65      -53.13     71.49                                   
REMARK 500    THR K  69       74.56     45.09                                   
REMARK 500    LEU K  70      101.61    -48.79                                   
REMARK 500    LYS K  71     -168.52   -164.45                                   
REMARK 500    GLU K  72      140.02    -34.73                                   
REMARK 500    ALA K 104      149.69   -172.58                                   
REMARK 500    LEU K 113      136.65    -36.21                                   
REMARK 500    LYS K 114     -169.64    -72.13                                   
REMARK 500    THR K 122       83.31     54.87                                   
REMARK 500    ASP K 123      -96.42     62.67                                   
REMARK 500    LEU K 124      157.17    -45.85                                   
REMARK 500    HIS K 130       93.50   -170.18                                   
REMARK 500    LYS K 136      -53.75     32.78                                   
REMARK 500    TYR K 138       29.88    -72.44                                   
REMARK 500    VAL K 141     -125.83    -76.58                                   
REMARK 500    THR K 142      -51.78     -3.39                                   
REMARK 500    HIS K 148     -163.03   -127.45                                   
REMARK 500    CYS K 162       85.00   -156.21                                   
REMARK 500    ASP K 167       -5.95    -59.40                                   
REMARK 500    LYS K 188      108.18     39.06                                   
REMARK 500    ALA K 190      -35.79    -37.50                                   
REMARK 500    SER K 191      107.67    176.58                                   
REMARK 500    ILE K 194       -7.84   -153.45                                   
REMARK 500    GLU K 195     -174.96    -49.23                                   
REMARK 500    LEU K 199       92.39     76.36                                   
REMARK 500    LEU K 202      134.81   -175.06                                   
REMARK 500    SER K 205       52.65     31.45                                   
REMARK 500    PRO K 207     -126.56   -134.16                                   
REMARK 500    LYS K 209       10.97     51.86                                   
REMARK 500    GLU K 212     -148.53     57.66                                   
REMARK 500    GLU K 213       95.07     75.91                                   
REMARK 500    LYS K 214      -66.18    -15.51                                   
REMARK 500    TYR K 229     -138.85     60.25                                   
REMARK 500    ASP K 230       37.82   -179.13                                   
REMARK 500    GLU K 234     -155.28    -73.07                                   
REMARK 500    ASP K 235      -40.77     71.38                                   
REMARK 500    SER K 238       42.45   -108.98                                   
REMARK 500    GLU K 242       94.31   -162.08                                   
REMARK 500    GLN K 264      -39.88    -33.77                                   
REMARK 500    ASP K 265      105.31    -52.56                                   
REMARK 500    ASP K 266      -27.99     63.80                                   
REMARK 500    GLU K 279       31.41    -80.88                                   
REMARK 500    ASN K 282       84.24     62.84                                   
REMARK 500    ASP K 293     -162.91   -128.89                                   
REMARK 500    ALA K 302      -57.91     79.20                                   
REMARK 500    THR K 303       35.19   -142.46                                   
REMARK 500    GLN K 306      177.72    -50.08                                   
REMARK 500    PHE K 310      -71.62    -53.37                                   
REMARK 500    ASN K 312      -41.51   -160.32                                   
REMARK 500    GLU K 326      -85.79   -120.46                                   
REMARK 500    LEU K 327      142.45    -32.81                                   
REMARK 500    LYS K 328      -69.28    -20.48                                   
REMARK 500    LEU K 329      -42.33     68.59                                   
REMARK 500    ARG K 330      -58.38     67.79                                   
REMARK 500    LYS K 331      -36.17    -30.62                                   
REMARK 500    SER K 340      106.07    -59.76                                   
REMARK 500    LYS K 357      -83.03     64.20                                   
REMARK 500    LEU K 363      102.80    -59.95                                   
REMARK 500    THR K 373       84.42   -162.42                                   
REMARK 500    SER K 375     -125.12   -128.61                                   
REMARK 500    ARG K 376       81.89    -59.51                                   
REMARK 500    SER K 400     -132.37     68.67                                   
REMARK 500    VAL K 401      126.53     78.83                                   
REMARK 500    LYS K 410      103.01    -54.51                                   
REMARK 500    VAL K 411     -108.61     31.65                                   
REMARK 500    ASP K 412       46.17    -66.85                                   
REMARK 500    GLN K 413      -90.57   -102.19                                   
REMARK 500    MET K 428      170.96    -56.41                                   
REMARK 500    ALA K 461       26.56    -74.74                                   
REMARK 500    LYS L   7      147.91    -30.28                                   
REMARK 500    GLU L   8       75.28   -168.12                                   
REMARK 500    TYR L   9       91.51    -48.08                                   
REMARK 500    TRP L  13     -173.17    -64.62                                   
REMARK 500    ASP L  14      -75.78     71.60                                   
REMARK 500    TYR L  16      -98.25    -58.82                                   
REMARK 500    ASP L  17     -116.96     45.08                                   
REMARK 500    ASP L  18       -9.40     60.95                                   
REMARK 500    LYS L  19      -25.40     67.95                                   
REMARK 500    GLN L  20      -72.52    -91.93                                   
REMARK 500    VAL L  24        6.34    -65.80                                   
REMARK 500    PHE L  25      -38.97   -156.58                                   
REMARK 500    ARG L  30       79.67    -68.12                                   
REMARK 500    PHE L  31      -65.25    170.25                                   
REMARK 500    PHE L  34      -32.95    -34.03                                   
REMARK 500    ASN L  37       35.75    -74.76                                   
REMARK 500    GLU L  43       27.77     13.12                                   
REMARK 500    TYR L  57      145.60     67.64                                   
REMARK 500    ARG L  58      -73.56   -176.72                                   
REMARK 500    ASN L  59      -91.02     42.35                                   
REMARK 500    ILE L  60      -82.01     27.37                                   
REMARK 500    ASP L  62       66.49    -67.43                                   
REMARK 500    ALA L  65      -53.37     71.12                                   
REMARK 500    THR L  69       74.27     44.95                                   
REMARK 500    LEU L  70      101.96    -48.70                                   
REMARK 500    LYS L  71     -167.93   -164.90                                   
REMARK 500    GLU L  72      139.97    -34.91                                   
REMARK 500    ALA L 104      148.15   -172.85                                   
REMARK 500    LEU L 113      138.71    -37.28                                   
REMARK 500    LYS L 114     -169.90    -72.54                                   
REMARK 500    THR L 122       82.31     54.71                                   
REMARK 500    ASP L 123      -96.71     64.12                                   
REMARK 500    LEU L 124      159.07    -46.20                                   
REMARK 500    HIS L 130       92.96   -169.84                                   
REMARK 500    TYR L 131      150.60    -46.75                                   
REMARK 500    LYS L 136      -52.86     32.47                                   
REMARK 500    TYR L 138       29.22    -72.69                                   
REMARK 500    VAL L 141     -125.92    -76.14                                   
REMARK 500    THR L 142      -53.54     -2.30                                   
REMARK 500    HIS L 148     -160.53   -126.92                                   
REMARK 500    CYS L 162       85.14   -156.30                                   
REMARK 500    LYS L 188      109.17     38.75                                   
REMARK 500    ALA L 190      -36.30    -36.36                                   
REMARK 500    SER L 191      106.67    177.03                                   
REMARK 500    ILE L 194       -7.58   -152.36                                   
REMARK 500    GLU L 195     -174.49    -49.12                                   
REMARK 500    LEU L 199       92.69     74.03                                   
REMARK 500    LEU L 202      134.59   -174.36                                   
REMARK 500    SER L 205       53.24     31.15                                   
REMARK 500    PRO L 207     -126.64   -134.12                                   
REMARK 500    LYS L 209       11.11     51.91                                   
REMARK 500    GLU L 212     -148.66     57.99                                   
REMARK 500    GLU L 213       94.88     75.83                                   
REMARK 500    LYS L 214      -67.50    -15.31                                   
REMARK 500    TYR L 229     -137.65     60.66                                   
REMARK 500    ASP L 230       37.48    179.49                                   
REMARK 500    GLU L 234     -153.11    -71.23                                   
REMARK 500    ASP L 235      -40.21     69.57                                   
REMARK 500    SER L 238       43.96   -109.59                                   
REMARK 500    GLU L 242       93.79   -161.70                                   
REMARK 500    ASP L 265      106.48    -53.65                                   
REMARK 500    ASP L 266      -27.98     63.34                                   
REMARK 500    GLU L 279       31.87    -80.57                                   
REMARK 500    ASN L 282       83.91     62.78                                   
REMARK 500    ASP L 293     -162.59   -129.60                                   
REMARK 500    ALA L 302      -56.75     80.53                                   
REMARK 500    THR L 303       34.78   -142.93                                   
REMARK 500    GLN L 306      178.38    -51.08                                   
REMARK 500    PHE L 310      -71.03    -53.79                                   
REMARK 500    ASN L 312      -41.20   -161.95                                   
REMARK 500    GLU L 326      -85.74   -120.92                                   
REMARK 500    LEU L 327      143.26    -32.35                                   
REMARK 500    LYS L 328      -69.26    -21.68                                   
REMARK 500    LEU L 329      -42.18     68.61                                   
REMARK 500    ARG L 330      -58.56     67.78                                   
REMARK 500    LYS L 331      -36.32    -31.08                                   
REMARK 500    LYS L 357      -83.23     63.97                                   
REMARK 500    LEU L 363      102.17    -59.95                                   
REMARK 500    THR L 373       85.76   -162.78                                   
REMARK 500    SER L 375     -125.11   -128.67                                   
REMARK 500    ARG L 376       81.97    -59.95                                   
REMARK 500    SER L 400     -133.73     68.76                                   
REMARK 500    VAL L 401      125.35     80.09                                   
REMARK 500    LYS L 410      102.72    -54.11                                   
REMARK 500    VAL L 411     -109.43     32.62                                   
REMARK 500    ASP L 412       47.63    -66.74                                   
REMARK 500    GLN L 413      -90.88   -102.97                                   
REMARK 500    ALA L 461       27.28    -75.88                                   
REMARK 500    GLU M   8     -124.02    -72.61                                   
REMARK 500    TYR M   9      -93.48    -81.09                                   
REMARK 500    LYS M  10      114.48     81.63                                   
REMARK 500    TRP M  13     -172.59    -64.44                                   
REMARK 500    ASP M  14      -74.63     71.73                                   
REMARK 500    TYR M  16      -96.25    -59.48                                   
REMARK 500    ASP M  17     -116.90     43.13                                   
REMARK 500    ASP M  18       -9.74     61.87                                   
REMARK 500    LYS M  19      -25.38     68.90                                   
REMARK 500    GLN M  20      -71.23    -91.92                                   
REMARK 500    VAL M  24        5.43    -64.75                                   
REMARK 500    PHE M  25      -38.37   -156.35                                   
REMARK 500    ARG M  30       78.90    -68.40                                   
REMARK 500    PHE M  31      -64.44    171.03                                   
REMARK 500    PHE M  34      -32.56    -34.40                                   
REMARK 500    ASN M  37       35.51    -75.32                                   
REMARK 500    GLU M  43       27.57     15.05                                   
REMARK 500    GLU M  53       16.23     59.32                                   
REMARK 500    TYR M  57      145.08     66.81                                   
REMARK 500    ARG M  58      -73.37   -176.77                                   
REMARK 500    ASN M  59      -89.76     42.26                                   
REMARK 500    ILE M  60      -80.78     25.95                                   
REMARK 500    ASP M  62       66.72    -66.74                                   
REMARK 500    ALA M  65      -52.78     71.08                                   
REMARK 500    THR M  69       74.02     45.51                                   
REMARK 500    LEU M  70      101.21    -48.35                                   
REMARK 500    LYS M  71     -168.52   -164.08                                   
REMARK 500    GLU M  72      140.00    -35.27                                   
REMARK 500    ALA M 104      148.64   -173.29                                   
REMARK 500    LEU M 113      136.99    -36.03                                   
REMARK 500    LYS M 114     -169.13    -72.12                                   
REMARK 500    THR M 122       83.10     54.27                                   
REMARK 500    ASP M 123      -95.83     62.98                                   
REMARK 500    LEU M 124      157.63    -46.71                                   
REMARK 500    HIS M 130       93.39   -169.95                                   
REMARK 500    LYS M 136      -53.80     32.92                                   
REMARK 500    TYR M 138       31.35    -73.05                                   
REMARK 500    VAL M 141     -126.33    -76.06                                   
REMARK 500    THR M 142      -51.92     -2.59                                   
REMARK 500    HIS M 148     -163.75   -129.02                                   
REMARK 500    CYS M 162       85.02   -155.59                                   
REMARK 500    ASP M 167       -5.94    -59.74                                   
REMARK 500    LYS M 188      106.69     39.60                                   
REMARK 500    ALA M 190      -35.63    -38.26                                   
REMARK 500    SER M 191      108.22    176.26                                   
REMARK 500    ILE M 194       -7.31   -152.72                                   
REMARK 500    GLU M 195     -175.37    -49.53                                   
REMARK 500    LEU M 199       92.63     74.90                                   
REMARK 500    LEU M 202      135.01   -174.63                                   
REMARK 500    SER M 205       52.32     32.07                                   
REMARK 500    PRO M 207     -128.67   -139.40                                   
REMARK 500    LYS M 209       11.02     51.39                                   
REMARK 500    GLU M 212     -148.41     57.69                                   
REMARK 500    GLU M 213       95.20     75.50                                   
REMARK 500    LYS M 214      -66.40    -15.75                                   
REMARK 500    TYR M 229     -138.16     59.50                                   
REMARK 500    ASP M 230       37.46   -179.92                                   
REMARK 500    GLU M 234     -154.50    -72.86                                   
REMARK 500    ASP M 235      -40.42     70.73                                   
REMARK 500    SER M 238       42.55   -108.78                                   
REMARK 500    GLU M 242       94.37   -161.77                                   
REMARK 500    ASP M 265      105.71    -52.76                                   
REMARK 500    ASP M 266      -27.63     63.53                                   
REMARK 500    GLU M 279       32.05    -79.92                                   
REMARK 500    ASN M 282       84.22     62.87                                   
REMARK 500    ASP M 293     -163.18   -129.64                                   
REMARK 500    ALA M 302      -57.11     78.85                                   
REMARK 500    THR M 303       34.88   -143.30                                   
REMARK 500    GLN M 306      177.38    -50.54                                   
REMARK 500    PHE M 310      -71.48    -52.84                                   
REMARK 500    ASN M 312      -40.10   -160.68                                   
REMARK 500    GLU M 326      -85.66   -121.59                                   
REMARK 500    LEU M 327      142.70    -32.87                                   
REMARK 500    LYS M 328      -69.33    -20.69                                   
REMARK 500    LEU M 329      -42.35     68.70                                   
REMARK 500    ARG M 330      -59.25     68.08                                   
REMARK 500    LYS M 331      -35.37    -30.47                                   
REMARK 500    SER M 340      106.52    -59.35                                   
REMARK 500    LYS M 357      -83.20     64.39                                   
REMARK 500    LEU M 363      101.91    -58.76                                   
REMARK 500    THR M 373       84.89   -163.26                                   
REMARK 500    SER M 375     -123.61   -128.66                                   
REMARK 500    ARG M 376       82.35    -60.85                                   
REMARK 500    LEU M 396       20.06    -71.56                                   
REMARK 500    SER M 400     -133.49     68.87                                   
REMARK 500    VAL M 401      126.21     80.06                                   
REMARK 500    LYS M 410      103.78    -55.54                                   
REMARK 500    VAL M 411     -109.17     31.27                                   
REMARK 500    ASP M 412       47.19    -66.43                                   
REMARK 500    GLN M 413      -90.38   -103.01                                   
REMARK 500    MET M 428      171.30    -55.60                                   
REMARK 500    ALA M 461       26.51    -75.02                                   
REMARK 500    LEU N   6      112.31   -170.04                                   
REMARK 500    TYR N   9      104.58    -44.57                                   
REMARK 500    TRP N  13     -172.87    -65.30                                   
REMARK 500    ASP N  14      -74.88     72.35                                   
REMARK 500    TYR N  16      -96.86    -59.29                                   
REMARK 500    ASP N  17     -116.82     43.48                                   
REMARK 500    ASP N  18       -8.80     61.35                                   
REMARK 500    LYS N  19      -25.17     67.44                                   
REMARK 500    GLN N  20      -70.88    -91.77                                   
REMARK 500    VAL N  24        5.14    -64.57                                   
REMARK 500    PHE N  25      -39.12   -156.37                                   
REMARK 500    ARG N  30       80.16    -68.58                                   
REMARK 500    PHE N  31      -63.91    169.28                                   
REMARK 500    PHE N  34      -33.32    -34.01                                   
REMARK 500    ASN N  37       36.73    -75.54                                   
REMARK 500    CYS N  38      -42.67   -130.23                                   
REMARK 500    GLU N  43       25.18     15.87                                   
REMARK 500    GLU N  53       16.41     59.69                                   
REMARK 500    TYR N  57      144.70     66.07                                   
REMARK 500    ARG N  58      -73.07   -176.82                                   
REMARK 500    ASN N  59      -90.15     41.91                                   
REMARK 500    ILE N  60      -81.74     26.46                                   
REMARK 500    ASP N  62       66.68    -67.34                                   
REMARK 500    ALA N  65      -53.11     71.41                                   
REMARK 500    THR N  69       74.35     45.02                                   
REMARK 500    LEU N  70      101.20    -48.74                                   
REMARK 500    LYS N  71     -168.33   -164.60                                   
REMARK 500    GLU N  72      140.07    -35.12                                   
REMARK 500    ALA N 104      149.38   -172.58                                   
REMARK 500    LEU N 113      140.81    -37.56                                   
REMARK 500    LYS N 114     -169.73    -74.18                                   
REMARK 500    THR N 122       83.46     53.88                                   
REMARK 500    ASP N 123      -97.68     62.48                                   
REMARK 500    LEU N 124      159.32    -44.93                                   
REMARK 500    HIS N 130       93.30   -169.13                                   
REMARK 500    TYR N 131      151.01    -46.64                                   
REMARK 500    LYS N 136      -53.46     33.20                                   
REMARK 500    TYR N 138       28.88    -73.21                                   
REMARK 500    VAL N 141     -126.35    -76.61                                   
REMARK 500    THR N 142      -52.12     -3.26                                   
REMARK 500    HIS N 148     -162.00   -126.63                                   
REMARK 500    CYS N 162       85.24   -156.48                                   
REMARK 500    ASP N 167       -6.27    -59.86                                   
REMARK 500    LYS N 188      107.89     39.13                                   
REMARK 500    ALA N 190      -36.48    -37.71                                   
REMARK 500    SER N 191      106.28    176.85                                   
REMARK 500    ILE N 194       -6.99   -152.06                                   
REMARK 500    GLU N 195     -173.95    -49.59                                   
REMARK 500    LEU N 199       92.04     74.96                                   
REMARK 500    LEU N 202      134.12   -174.33                                   
REMARK 500    SER N 205       52.68     32.05                                   
REMARK 500    PRO N 207     -127.71   -136.80                                   
REMARK 500    LYS N 209       11.44     51.07                                   
REMARK 500    GLU N 212     -148.85     57.69                                   
REMARK 500    GLU N 213       95.52     76.06                                   
REMARK 500    LYS N 214      -67.37    -15.95                                   
REMARK 500    TYR N 229     -138.26     60.26                                   
REMARK 500    ASP N 230       37.34   -179.34                                   
REMARK 500    GLU N 234     -152.20    -72.58                                   
REMARK 500    ASP N 235      -40.83     69.08                                   
REMARK 500    SER N 238       42.47   -107.95                                   
REMARK 500    GLU N 242       95.54   -162.51                                   
REMARK 500    ASP N 265      105.72    -51.32                                   
REMARK 500    ASP N 266      -28.30     62.89                                   
REMARK 500    GLU N 279       31.29    -80.89                                   
REMARK 500    ASN N 282       83.91     62.64                                   
REMARK 500    SER N 299       32.91     70.24                                   
REMARK 500    ILE N 300      176.01    -59.63                                   
REMARK 500    ALA N 302      -57.94     80.46                                   
REMARK 500    THR N 303       34.32   -142.09                                   
REMARK 500    GLN N 306      178.26    -49.66                                   
REMARK 500    PHE N 310      -70.78    -53.51                                   
REMARK 500    ASN N 312      -40.93   -162.00                                   
REMARK 500    GLU N 326      -85.73   -121.28                                   
REMARK 500    LEU N 327      143.09    -32.50                                   
REMARK 500    LYS N 328      -69.40    -21.19                                   
REMARK 500    LEU N 329      -41.95     68.68                                   
REMARK 500    ARG N 330      -59.17     68.09                                   
REMARK 500    LYS N 331      -36.06    -30.51                                   
REMARK 500    LYS N 357      -84.16     63.99                                   
REMARK 500    LEU N 363      101.00    -60.00                                   
REMARK 500    THR N 373       84.34   -162.20                                   
REMARK 500    SER N 375     -124.84   -128.83                                   
REMARK 500    ARG N 376       81.51    -59.86                                   
REMARK 500    LYS N 378       17.54     59.96                                   
REMARK 500    SER N 400     -132.89     69.19                                   
REMARK 500    VAL N 401      126.32     79.98                                   
REMARK 500    LYS N 410      102.63    -54.24                                   
REMARK 500    VAL N 411     -109.41     32.18                                   
REMARK 500    ASP N 412       47.40    -66.66                                   
REMARK 500    GLN N 413      -90.69   -102.55                                   
REMARK 500    MET N 428      171.01    -56.36                                   
REMARK 500    ALA N 461       28.15    -76.69                                   
REMARK 500    GLU O   8       97.34   -165.55                                   
REMARK 500    TRP O  13     -171.58    -64.34                                   
REMARK 500    ASP O  14      -74.30     70.83                                   
REMARK 500    TYR O  16      -97.62    -59.72                                   
REMARK 500    ASP O  17     -116.88     44.99                                   
REMARK 500    ASP O  18       -9.40     61.35                                   
REMARK 500    LYS O  19      -25.71     67.74                                   
REMARK 500    GLN O  20      -72.00    -91.42                                   
REMARK 500    VAL O  24        5.25    -65.28                                   
REMARK 500    PHE O  25      -39.33   -155.82                                   
REMARK 500    ARG O  30       79.52    -67.74                                   
REMARK 500    PHE O  31      -65.63    170.40                                   
REMARK 500    PHE O  34      -31.93    -35.44                                   
REMARK 500    ASN O  37       34.74    -74.72                                   
REMARK 500    GLU O  43       26.40     14.78                                   
REMARK 500    GLU O  53       17.02     59.44                                   
REMARK 500    TYR O  57      144.69     65.99                                   
REMARK 500    ARG O  58      -74.27   -176.48                                   
REMARK 500    ASN O  59      -90.76     42.87                                   
REMARK 500    ILE O  60      -81.05     26.86                                   
REMARK 500    ASP O  62       65.66    -66.07                                   
REMARK 500    ALA O  65      -52.30     70.92                                   
REMARK 500    THR O  69       75.13     44.79                                   
REMARK 500    LEU O  70      102.57    -49.61                                   
REMARK 500    LYS O  71     -168.15   -165.01                                   
REMARK 500    GLU O  72      140.15    -35.21                                   
REMARK 500    ALA O 104      147.96   -172.27                                   
REMARK 500    LEU O 113      139.37    -35.81                                   
REMARK 500    LYS O 114     -169.46    -73.58                                   
REMARK 500    THR O 122       83.71     54.32                                   
REMARK 500    ASP O 123      -95.96     62.00                                   
REMARK 500    LEU O 124      159.12    -45.76                                   
REMARK 500    HIS O 130       93.13   -169.85                                   
REMARK 500    LYS O 136      -52.81     31.63                                   
REMARK 500    TYR O 138       30.07    -74.37                                   
REMARK 500    VAL O 141     -123.42    -75.65                                   
REMARK 500    THR O 142      -54.11     -4.88                                   
REMARK 500    HIS O 148     -161.33   -127.84                                   
REMARK 500    CYS O 162       84.78   -157.31                                   
REMARK 500    ASP O 167       -5.34    -59.69                                   
REMARK 500    LYS O 188      109.19     39.77                                   
REMARK 500    ALA O 190      -35.95    -37.06                                   
REMARK 500    SER O 191      106.78    176.71                                   
REMARK 500    ILE O 194       -7.11   -151.60                                   
REMARK 500    GLU O 195     -175.54    -49.13                                   
REMARK 500    LEU O 199       91.73     75.30                                   
REMARK 500    LEU O 202      135.29   -176.70                                   
REMARK 500    SER O 205       53.35     31.23                                   
REMARK 500    PRO O 207     -129.87   -141.29                                   
REMARK 500    LYS O 209       10.89     51.84                                   
REMARK 500    GLU O 212     -148.59     57.97                                   
REMARK 500    GLU O 213       94.79     75.75                                   
REMARK 500    LYS O 214      -66.60    -15.48                                   
REMARK 500    TYR O 229     -138.75     59.92                                   
REMARK 500    ASP O 230       38.17   -179.32                                   
REMARK 500    GLU O 234     -153.33    -71.63                                   
REMARK 500    ASP O 235      -40.62     69.86                                   
REMARK 500    SER O 238       41.61   -108.86                                   
REMARK 500    GLU O 242       93.66   -162.26                                   
REMARK 500    ASP O 265      105.08    -51.88                                   
REMARK 500    ASP O 266      -27.59     64.25                                   
REMARK 500    GLU O 279       31.03    -80.92                                   
REMARK 500    ASN O 282       83.95     62.59                                   
REMARK 500    ASP O 293     -162.37   -129.91                                   
REMARK 500    ALA O 302      -57.09     80.60                                   
REMARK 500    THR O 303       35.52   -143.48                                   
REMARK 500    GLN O 306      178.67    -51.59                                   
REMARK 500    PHE O 310      -70.39    -53.19                                   
REMARK 500    ASN O 312      -40.66   -161.89                                   
REMARK 500    GLU O 326      -84.81   -121.08                                   
REMARK 500    LEU O 327      142.86    -33.67                                   
REMARK 500    LYS O 328      -69.27    -20.62                                   
REMARK 500    LEU O 329      -43.23     68.45                                   
REMARK 500    ARG O 330      -58.34     68.74                                   
REMARK 500    LYS O 331      -35.62    -31.32                                   
REMARK 500    SER O 340      107.91    -57.69                                   
REMARK 500    LYS O 357      -83.64     64.39                                   
REMARK 500    THR O 373       84.39   -164.46                                   
REMARK 500    SER O 375     -123.85   -128.59                                   
REMARK 500    ARG O 376       82.51    -60.63                                   
REMARK 500    LYS O 378       18.30     59.71                                   
REMARK 500    SER O 400     -133.14     68.37                                   
REMARK 500    VAL O 401      126.63     79.54                                   
REMARK 500    LYS O 410      104.32    -55.80                                   
REMARK 500    VAL O 411     -109.89     31.19                                   
REMARK 500    ASP O 412       46.96    -66.43                                   
REMARK 500    GLN O 413      -91.67   -102.33                                   
REMARK 500    MET O 428      170.48    -56.55                                   
REMARK 500    ALA O 461       26.78    -74.32                                   
REMARK 500    LYS P   7      118.75      4.55                                   
REMARK 500    TRP P  13     -172.27    -64.74                                   
REMARK 500    ASP P  14      -74.52     71.38                                   
REMARK 500    TYR P  16      -96.94    -59.62                                   
REMARK 500    ASP P  17     -116.88     43.38                                   
REMARK 500    ASP P  18       -9.10     61.44                                   
REMARK 500    LYS P  19      -24.68     67.38                                   
REMARK 500    GLN P  20      -70.63    -92.54                                   
REMARK 500    VAL P  24        5.51    -64.34                                   
REMARK 500    PHE P  25      -38.27   -156.74                                   
REMARK 500    ARG P  30       80.15    -68.34                                   
REMARK 500    PHE P  31      -65.20    169.74                                   
REMARK 500    PHE P  34      -32.11    -35.04                                   
REMARK 500    ASN P  37       36.59    -75.86                                   
REMARK 500    CYS P  38      -40.60   -130.45                                   
REMARK 500    GLU P  43       26.15     15.38                                   
REMARK 500    GLU P  53       16.01     59.62                                   
REMARK 500    TYR P  57      145.13     67.04                                   
REMARK 500    ARG P  58      -74.39   -176.68                                   
REMARK 500    ASN P  59      -90.36     43.14                                   
REMARK 500    ILE P  60      -81.42     26.36                                   
REMARK 500    ASP P  62       66.27    -67.28                                   
REMARK 500    ALA P  65      -52.71     71.62                                   
REMARK 500    THR P  69       74.72     45.05                                   
REMARK 500    LEU P  70      102.10    -49.36                                   
REMARK 500    LYS P  71     -168.25   -164.68                                   
REMARK 500    GLU P  72      139.94    -35.30                                   
REMARK 500    ALA P 104      147.88   -172.21                                   
REMARK 500    LEU P 113      139.44    -36.12                                   
REMARK 500    THR P 122       83.57     55.09                                   
REMARK 500    ASP P 123      -96.72     62.79                                   
REMARK 500    LEU P 124      159.76    -45.77                                   
REMARK 500    HIS P 130       93.60   -169.86                                   
REMARK 500    LYS P 136      -53.26     32.22                                   
REMARK 500    TYR P 138       30.07    -73.87                                   
REMARK 500    VAL P 141     -124.87    -75.99                                   
REMARK 500    THR P 142      -53.26     -4.67                                   
REMARK 500    HIS P 148     -160.86   -127.86                                   
REMARK 500    CYS P 162       85.28   -156.82                                   
REMARK 500    ASP P 167       -6.40    -59.81                                   
REMARK 500    LYS P 188      107.79     39.17                                   
REMARK 500    ALA P 190      -35.36    -37.71                                   
REMARK 500    SER P 191      107.37    175.92                                   
REMARK 500    ILE P 194       -7.23   -151.60                                   
REMARK 500    GLU P 195     -174.55    -49.53                                   
REMARK 500    LEU P 199       91.82     75.87                                   
REMARK 500    LEU P 202      135.59   -174.28                                   
REMARK 500    SER P 205       52.51     33.13                                   
REMARK 500    PRO P 207     -126.19   -137.24                                   
REMARK 500    LYS P 209       11.55     52.40                                   
REMARK 500    GLU P 212     -148.70     57.59                                   
REMARK 500    GLU P 213       94.94     76.08                                   
REMARK 500    LYS P 214      -67.16    -15.16                                   
REMARK 500    TYR P 229     -138.81     59.87                                   
REMARK 500    ASP P 230       37.27   -179.25                                   
REMARK 500    GLU P 234     -154.09    -71.27                                   
REMARK 500    ASP P 235      -40.75     70.45                                   
REMARK 500    GLU P 242       94.02   -161.96                                   
REMARK 500    ASP P 265      106.10    -52.42                                   
REMARK 500    ASP P 266      -28.81     62.97                                   
REMARK 500    GLU P 279       32.64    -81.77                                   
REMARK 500    ASN P 282       84.00     62.72                                   
REMARK 500    ALA P 302      -57.19     80.70                                   
REMARK 500    THR P 303       34.55   -143.27                                   
REMARK 500    GLN P 306      177.98    -50.66                                   
REMARK 500    PHE P 310      -70.71    -53.00                                   
REMARK 500    ASN P 312      -40.73   -160.90                                   
REMARK 500    GLU P 326      -85.60   -121.05                                   
REMARK 500    LEU P 327      142.77    -32.58                                   
REMARK 500    LYS P 328      -69.47    -20.91                                   
REMARK 500    LEU P 329      -42.73     68.49                                   
REMARK 500    ARG P 330      -58.31     68.69                                   
REMARK 500    LYS P 331      -36.51    -30.98                                   
REMARK 500    SER P 340      106.85    -59.02                                   
REMARK 500    LYS P 357      -83.76     63.82                                   
REMARK 500    LEU P 363      103.36    -59.97                                   
REMARK 500    THR P 373       84.85   -163.11                                   
REMARK 500    SER P 375     -125.21   -128.66                                   
REMARK 500    ARG P 376       81.90    -59.60                                   
REMARK 500    LEU P 396       20.51    -69.62                                   
REMARK 500    SER P 400     -132.78     68.12                                   
REMARK 500    VAL P 401      125.99     79.64                                   
REMARK 500    LYS P 410      103.77    -54.28                                   
REMARK 500    VAL P 411     -109.16     31.58                                   
REMARK 500    ASP P 412       47.19    -66.62                                   
REMARK 500    GLN P 413      -91.05   -103.46                                   
REMARK 500    ILE P 419       20.21    -79.95                                   
REMARK 500    MET P 428      170.57    -55.16                                   
REMARK 500    ALA P 461       27.43    -75.96                                   
REMARK 500    ASN P 464     -144.02   -145.47                                   
REMARK 500    TRP Q  13     -171.99    -65.79                                   
REMARK 500    ASP Q  14      -75.74     70.79                                   
REMARK 500    TYR Q  16      -97.94    -59.54                                   
REMARK 500    ASP Q  17     -116.46     44.73                                   
REMARK 500    ASP Q  18       -9.17     60.79                                   
REMARK 500    LYS Q  19      -25.44     68.00                                   
REMARK 500    GLN Q  20      -71.77    -91.87                                   
REMARK 500    VAL Q  24        5.04    -65.29                                   
REMARK 500    PHE Q  25      -38.79   -155.34                                   
REMARK 500    ARG Q  30       80.18    -68.16                                   
REMARK 500    PHE Q  31      -65.60    169.85                                   
REMARK 500    PHE Q  34      -32.76    -35.28                                   
REMARK 500    ASN Q  37       35.71    -75.41                                   
REMARK 500    GLU Q  43       27.24     14.06                                   
REMARK 500    TYR Q  57      145.07     67.57                                   
REMARK 500    ARG Q  58      -74.50   -176.96                                   
REMARK 500    ASN Q  59      -90.69     43.02                                   
REMARK 500    ILE Q  60      -81.91     26.88                                   
REMARK 500    ASP Q  62       66.41    -67.31                                   
REMARK 500    ALA Q  65      -53.31     70.96                                   
REMARK 500    THR Q  69       74.45     45.46                                   
REMARK 500    LEU Q  70      101.52    -48.75                                   
REMARK 500    LYS Q  71     -168.45   -164.59                                   
REMARK 500    GLU Q  72      139.96    -34.40                                   
REMARK 500    ALA Q 104      148.08   -171.87                                   
REMARK 500    LEU Q 113      139.11    -37.29                                   
REMARK 500    THR Q 122       82.50     55.50                                   
REMARK 500    ASP Q 123      -97.32     63.14                                   
REMARK 500    LEU Q 124      159.37    -44.52                                   
REMARK 500    HIS Q 130       92.50   -168.94                                   
REMARK 500    LYS Q 136      -53.16     32.87                                   
REMARK 500    TYR Q 138       28.88    -73.22                                   
REMARK 500    VAL Q 141     -126.24    -75.92                                   
REMARK 500    THR Q 142      -51.52     -3.35                                   
REMARK 500    HIS Q 148     -160.92   -127.79                                   
REMARK 500    CYS Q 162       86.10   -155.89                                   
REMARK 500    LYS Q 188      108.49     39.32                                   
REMARK 500    ALA Q 190      -35.27    -36.50                                   
REMARK 500    SER Q 191      106.96    176.20                                   
REMARK 500    ILE Q 194       -7.40   -152.91                                   
REMARK 500    GLU Q 195     -176.09    -48.96                                   
REMARK 500    LEU Q 199       93.30     73.52                                   
REMARK 500    LEU Q 202      134.64   -175.03                                   
REMARK 500    SER Q 205       53.28     31.14                                   
REMARK 500    PRO Q 207     -126.11   -133.61                                   
REMARK 500    LYS Q 209       11.56     51.90                                   
REMARK 500    GLU Q 212     -148.52     58.14                                   
REMARK 500    GLU Q 213       95.05     75.38                                   
REMARK 500    LYS Q 214      -67.51    -15.55                                   
REMARK 500    TYR Q 229     -138.70     60.41                                   
REMARK 500    ASP Q 230       37.52   -178.86                                   
REMARK 500    GLU Q 234     -153.73    -71.90                                   
REMARK 500    ASP Q 235      -40.93     70.27                                   
REMARK 500    SER Q 238       43.52   -109.53                                   
REMARK 500    GLU Q 242       94.63   -161.33                                   
REMARK 500    GLN Q 264      -39.76    -35.83                                   
REMARK 500    ASP Q 265      106.39    -52.42                                   
REMARK 500    ASP Q 266      -26.93     62.39                                   
REMARK 500    GLU Q 279       32.76    -82.43                                   
REMARK 500    ASN Q 282       83.87     62.75                                   
REMARK 500    SER Q 299       32.78     70.18                                   
REMARK 500    ALA Q 302      -57.28     80.07                                   
REMARK 500    THR Q 303       35.63   -143.34                                   
REMARK 500    GLN Q 306      178.30    -51.03                                   
REMARK 500    PHE Q 310      -71.67    -53.56                                   
REMARK 500    ASN Q 312      -41.44   -160.45                                   
REMARK 500    GLU Q 326      -85.87   -121.35                                   
REMARK 500    LEU Q 327      142.89    -32.31                                   
REMARK 500    LYS Q 328      -69.29    -21.32                                   
REMARK 500    LEU Q 329      -42.20     68.45                                   
REMARK 500    ARG Q 330      -58.54     67.84                                   
REMARK 500    LYS Q 331      -36.50    -30.52                                   
REMARK 500    LYS Q 357      -82.58     64.69                                   
REMARK 500    THR Q 373       85.68   -162.61                                   
REMARK 500    SER Q 375     -124.79   -128.85                                   
REMARK 500    ARG Q 376       81.74    -60.27                                   
REMARK 500    SER Q 400     -133.81     67.59                                   
REMARK 500    VAL Q 401      126.69     80.92                                   
REMARK 500    LYS Q 410      103.51    -53.95                                   
REMARK 500    VAL Q 411     -109.60     32.00                                   
REMARK 500    ASP Q 412       46.23    -66.50                                   
REMARK 500    GLN Q 413      -90.92   -101.88                                   
REMARK 500    MET Q 428      170.61    -56.40                                   
REMARK 500    ALA Q 461       27.99    -75.21                                   
REMARK 500    LYS R  10     -123.47     30.37                                   
REMARK 500    TRP R  13     -172.41    -66.22                                   
REMARK 500    ASP R  14      -74.29     72.02                                   
REMARK 500    TYR R  16      -97.59    -59.73                                   
REMARK 500    ASP R  17     -116.21     44.24                                   
REMARK 500    ASP R  18       -9.27     60.57                                   
REMARK 500    LYS R  19      -25.68     68.40                                   
REMARK 500    GLN R  20      -71.69    -91.77                                   
REMARK 500    VAL R  24        5.32    -63.57                                   
REMARK 500    PHE R  25      -38.66   -156.46                                   
REMARK 500    ARG R  30       79.33    -68.47                                   
REMARK 500    PHE R  31      -65.36    170.16                                   
REMARK 500    PHE R  34      -33.22    -35.85                                   
REMARK 500    ASN R  37       35.14    -74.80                                   
REMARK 500    GLU R  43       25.13     15.84                                   
REMARK 500    GLU R  53       16.88     58.67                                   
REMARK 500    TYR R  57      144.90     66.69                                   
REMARK 500    ARG R  58      -74.52   -176.82                                   
REMARK 500    ASN R  59      -91.29     43.31                                   
REMARK 500    ILE R  60      -81.26     27.12                                   
REMARK 500    ASP R  62       67.17    -67.65                                   
REMARK 500    ALA R  65      -53.26     71.76                                   
REMARK 500    THR R  69       73.78     45.29                                   
REMARK 500    LEU R  70      101.87    -48.47                                   
REMARK 500    LYS R  71     -168.58   -164.53                                   
REMARK 500    GLU R  72      140.02    -34.94                                   
REMARK 500    ALA R 104      147.38   -173.12                                   
REMARK 500    LEU R 113      139.17    -34.42                                   
REMARK 500    LYS R 114     -168.11    -73.35                                   
REMARK 500    THR R 122       83.58     54.63                                   
REMARK 500    ASP R 123      -97.27     63.03                                   
REMARK 500    LEU R 124      159.32    -45.33                                   
REMARK 500    HIS R 130       93.49   -169.65                                   
REMARK 500    TYR R 131      150.06    -47.42                                   
REMARK 500    LYS R 136      -52.90     31.59                                   
REMARK 500    TYR R 138       30.81    -75.15                                   
REMARK 500    VAL R 141     -126.59    -76.41                                   
REMARK 500    THR R 142      -55.08     -2.26                                   
REMARK 500    HIS R 148     -162.34   -127.57                                   
REMARK 500    CYS R 162       83.89   -156.47                                   
REMARK 500    LYS R 188      108.91     39.07                                   
REMARK 500    ALA R 190      -35.28    -37.27                                   
REMARK 500    SER R 191      107.07    175.36                                   
REMARK 500    ILE R 194       -8.27   -152.30                                   
REMARK 500    GLU R 195     -175.70    -48.59                                   
REMARK 500    LEU R 199       92.93     74.66                                   
REMARK 500    LEU R 202      134.92   -176.09                                   
REMARK 500    SER R 205       52.01     31.74                                   
REMARK 500    PRO R 207     -128.29   -138.90                                   
REMARK 500    LYS R 209       11.19     51.74                                   
REMARK 500    GLU R 212     -148.05     57.86                                   
REMARK 500    GLU R 213       94.19     75.66                                   
REMARK 500    LYS R 214      -66.10    -14.43                                   
REMARK 500    TYR R 229     -138.54     59.25                                   
REMARK 500    ASP R 230       38.60   -179.60                                   
REMARK 500    GLU R 234     -152.84    -72.32                                   
REMARK 500    ASP R 235      -41.25     69.82                                   
REMARK 500    SER R 238       41.55   -109.35                                   
REMARK 500    GLU R 242       91.95   -162.22                                   
REMARK 500    ASP R 265      106.06    -53.22                                   
REMARK 500    ASP R 266      -28.80     63.53                                   
REMARK 500    GLU R 279       31.11    -80.13                                   
REMARK 500    ASN R 282       83.97     62.58                                   
REMARK 500    ALA R 302      -56.89     80.05                                   
REMARK 500    THR R 303       35.25   -143.44                                   
REMARK 500    GLN R 306      178.15    -50.82                                   
REMARK 500    PHE R 310      -70.98    -53.99                                   
REMARK 500    ASN R 312      -41.80   -161.29                                   
REMARK 500    GLU R 326      -85.86   -121.16                                   
REMARK 500    LEU R 327      142.78    -32.49                                   
REMARK 500    LYS R 328      -69.00    -21.06                                   
REMARK 500    LEU R 329      -42.63     68.23                                   
REMARK 500    ARG R 330      -58.28     68.47                                   
REMARK 500    LYS R 331      -36.46    -31.27                                   
REMARK 500    SER R 340      106.19    -58.79                                   
REMARK 500    LYS R 357      -82.66     63.05                                   
REMARK 500    LEU R 363      102.22    -59.91                                   
REMARK 500    THR R 373       85.12   -163.73                                   
REMARK 500    SER R 375     -124.45   -129.01                                   
REMARK 500    ARG R 376       80.34    -60.02                                   
REMARK 500    LEU R 396       20.23    -71.41                                   
REMARK 500    SER R 400     -134.82     67.74                                   
REMARK 500    VAL R 401      125.79     81.92                                   
REMARK 500    LYS R 410      101.87    -55.17                                   
REMARK 500    VAL R 411     -109.97     33.33                                   
REMARK 500    ASP R 412       48.33    -66.41                                   
REMARK 500    GLN R 413      -91.54   -103.92                                   
REMARK 500    MET R 428      171.82    -57.11                                   
REMARK 500    ALA R 461       26.90    -75.67                                   
REMARK 500    ASN R 464     -165.80    -76.87                                   
REMARK 500    LYS S   7       86.35     77.04                                   
REMARK 500    TRP S  13     -172.76    -66.25                                   
REMARK 500    ASP S  14      -75.46     72.49                                   
REMARK 500    TYR S  16      -98.20    -58.90                                   
REMARK 500    ASP S  17     -116.68     44.71                                   
REMARK 500    ASP S  18       -9.11     60.70                                   
REMARK 500    LYS S  19      -25.45     68.33                                   
REMARK 500    GLN S  20      -71.16    -92.42                                   
REMARK 500    VAL S  24        5.43    -65.51                                   
REMARK 500    PHE S  25      -39.98   -156.00                                   
REMARK 500    ARG S  30       78.52    -68.04                                   
REMARK 500    PHE S  31      -63.95    171.16                                   
REMARK 500    PHE S  34      -31.22    -33.94                                   
REMARK 500    ASN S  37       36.39    -75.11                                   
REMARK 500    CYS S  38      -40.26   -130.86                                   
REMARK 500    GLU S  43       27.86     13.30                                   
REMARK 500    GLU S  53       16.55     58.58                                   
REMARK 500    TYR S  57      145.09     65.76                                   
REMARK 500    ARG S  58      -74.20   -176.51                                   
REMARK 500    ASN S  59      -89.65     43.08                                   
REMARK 500    ILE S  60      -81.63     25.68                                   
REMARK 500    ASP S  62       67.02    -67.66                                   
REMARK 500    ALA S  65      -53.58     71.85                                   
REMARK 500    THR S  69       74.25     45.97                                   
REMARK 500    LEU S  70      101.15    -48.68                                   
REMARK 500    LYS S  71     -168.24   -164.08                                   
REMARK 500    GLU S  72      139.71    -34.54                                   
REMARK 500    ALA S 104      148.72   -170.34                                   
REMARK 500    LEU S 113      138.60    -37.84                                   
REMARK 500    THR S 122       82.97     53.81                                   
REMARK 500    ASP S 123      -96.81     62.40                                   
REMARK 500    LEU S 124      158.42    -45.37                                   
REMARK 500    HIS S 130       94.38   -169.34                                   
REMARK 500    LYS S 136      -54.28     33.65                                   
REMARK 500    TYR S 138       27.64    -73.12                                   
REMARK 500    VAL S 141     -126.23    -76.18                                   
REMARK 500    THR S 142      -54.68     -2.45                                   
REMARK 500    HIS S 148     -163.04   -127.97                                   
REMARK 500    CYS S 162       85.81   -156.97                                   
REMARK 500    ASP S 167       -5.65    -59.98                                   
REMARK 500    LYS S 188      106.93     39.78                                   
REMARK 500    ALA S 190      -36.62    -35.46                                   
REMARK 500    SER S 191      107.45    176.73                                   
REMARK 500    ILE S 194       -8.51   -151.50                                   
REMARK 500    GLU S 195     -174.80    -49.05                                   
REMARK 500    LEU S 199       94.23     74.82                                   
REMARK 500    LEU S 202      134.95   -175.13                                   
REMARK 500    SER S 205       52.26     32.87                                   
REMARK 500    PRO S 207     -126.34   -134.41                                   
REMARK 500    LYS S 209       11.69     51.20                                   
REMARK 500    GLU S 212     -148.20     58.34                                   
REMARK 500    GLU S 213       94.84     75.61                                   
REMARK 500    LYS S 214      -67.00    -15.50                                   
REMARK 500    TYR S 229     -138.73     58.98                                   
REMARK 500    ASP S 230       37.69   -179.45                                   
REMARK 500    GLU S 234     -152.46    -72.42                                   
REMARK 500    ASP S 235      -39.94     69.74                                   
REMARK 500    SER S 238       42.42   -109.84                                   
REMARK 500    GLU S 242       95.08   -161.51                                   
REMARK 500    GLN S 264      -39.75    -35.77                                   
REMARK 500    ASP S 265      104.94    -53.23                                   
REMARK 500    ASP S 266      -27.63     63.91                                   
REMARK 500    GLU S 279       31.81    -79.52                                   
REMARK 500    ASN S 282       83.53     62.15                                   
REMARK 500    ASP S 293     -163.73   -129.17                                   
REMARK 500    ALA S 302      -56.20     80.40                                   
REMARK 500    THR S 303       34.90   -143.72                                   
REMARK 500    GLN S 306      178.94    -50.79                                   
REMARK 500    PHE S 310      -71.51    -53.02                                   
REMARK 500    ASN S 312      -41.46   -160.33                                   
REMARK 500    GLU S 326      -85.39   -121.47                                   
REMARK 500    LEU S 327      143.22    -32.77                                   
REMARK 500    LYS S 328      -69.25    -21.47                                   
REMARK 500    LEU S 329      -42.16     68.19                                   
REMARK 500    ARG S 330      -58.88     68.45                                   
REMARK 500    LYS S 331      -35.53    -30.40                                   
REMARK 500    SER S 340      107.39    -59.31                                   
REMARK 500    LYS S 357      -83.04     64.02                                   
REMARK 500    LEU S 363      103.06    -59.69                                   
REMARK 500    THR S 373       84.20   -163.12                                   
REMARK 500    SER S 375     -123.71   -129.28                                   
REMARK 500    ARG S 376       81.85    -60.48                                   
REMARK 500    LEU S 396       21.14    -72.27                                   
REMARK 500    SER S 400     -133.31     68.65                                   
REMARK 500    VAL S 401      126.43     79.28                                   
REMARK 500    LYS S 410      103.05    -54.41                                   
REMARK 500    VAL S 411     -108.96     32.57                                   
REMARK 500    ASP S 412       45.97    -66.63                                   
REMARK 500    GLN S 413      -91.19   -102.19                                   
REMARK 500    ALA S 461       28.03    -74.10                                   
REMARK 500    TYR T   9      102.84    -35.03                                   
REMARK 500    LYS T  10      172.10    -57.05                                   
REMARK 500    TRP T  13     -172.60    -65.16                                   
REMARK 500    ASP T  14      -75.26     71.45                                   
REMARK 500    TYR T  16      -98.01    -57.66                                   
REMARK 500    ASP T  17     -116.46     44.77                                   
REMARK 500    ASP T  18       -9.17     61.03                                   
REMARK 500    LYS T  19      -25.62     68.00                                   
REMARK 500    GLN T  20      -70.79    -91.59                                   
REMARK 500    VAL T  24        5.70    -63.39                                   
REMARK 500    PHE T  25      -38.00   -156.83                                   
REMARK 500    ARG T  30       80.65    -68.40                                   
REMARK 500    PHE T  31      -67.15    169.39                                   
REMARK 500    PHE T  34      -32.30    -34.78                                   
REMARK 500    ASN T  37       36.26    -75.94                                   
REMARK 500    CYS T  38      -41.59   -130.24                                   
REMARK 500    GLU T  43       27.29     14.35                                   
REMARK 500    GLU T  53       15.86     59.46                                   
REMARK 500    TYR T  57      144.85     66.10                                   
REMARK 500    ARG T  58      -74.65   -176.71                                   
REMARK 500    ASN T  59      -90.62     43.05                                   
REMARK 500    ILE T  60      -81.64     26.66                                   
REMARK 500    ASP T  62       66.13    -67.85                                   
REMARK 500    ALA T  65      -52.82     71.19                                   
REMARK 500    THR T  69       74.81     44.89                                   
REMARK 500    LEU T  70      101.40    -49.11                                   
REMARK 500    LYS T  71     -168.24   -164.41                                   
REMARK 500    GLU T  72      139.43    -34.81                                   
REMARK 500    ALA T 104      149.64   -173.31                                   
REMARK 500    LEU T 113      138.12    -38.40                                   
REMARK 500    LYS T 114     -169.83    -72.67                                   
REMARK 500    THR T 122       82.89     54.50                                   
REMARK 500    ASP T 123      -97.14     63.61                                   
REMARK 500    LEU T 124      159.12    -45.22                                   
REMARK 500    HIS T 130       94.87   -167.80                                   
REMARK 500    TYR T 131      150.09    -48.75                                   
REMARK 500    LYS T 136      -53.95     32.13                                   
REMARK 500    TYR T 138       29.16    -73.51                                   
REMARK 500    VAL T 141     -125.23    -75.61                                   
REMARK 500    THR T 142      -54.56     -3.61                                   
REMARK 500    HIS T 148     -161.82   -126.98                                   
REMARK 500    CYS T 162       86.81   -155.87                                   
REMARK 500    LYS T 188      109.64     39.00                                   
REMARK 500    ALA T 190      -35.85    -36.15                                   
REMARK 500    SER T 191      107.16    176.16                                   
REMARK 500    ILE T 194       -8.32   -152.09                                   
REMARK 500    GLU T 195     -174.05    -48.94                                   
REMARK 500    LEU T 199       93.25     74.85                                   
REMARK 500    LEU T 202      134.21   -174.48                                   
REMARK 500    SER T 205       52.48     31.92                                   
REMARK 500    PRO T 207     -127.15   -137.18                                   
REMARK 500    LYS T 209       11.10     51.37                                   
REMARK 500    GLU T 212     -148.09     57.83                                   
REMARK 500    GLU T 213       95.30     75.64                                   
REMARK 500    LYS T 214      -67.21    -15.80                                   
REMARK 500    TYR T 229     -138.30     59.83                                   
REMARK 500    ASP T 230       36.71    179.98                                   
REMARK 500    GLU T 234     -152.56    -72.29                                   
REMARK 500    ASP T 235      -41.39     70.08                                   
REMARK 500    SER T 238       41.17   -108.66                                   
REMARK 500    GLU T 242       93.15   -161.14                                   
REMARK 500    ASP T 265      103.95    -50.71                                   
REMARK 500    ASP T 266      -27.74     64.46                                   
REMARK 500    GLU T 279       31.46    -79.87                                   
REMARK 500    ASN T 282       84.18     62.19                                   
REMARK 500    SER T 299       32.72     70.36                                   
REMARK 500    ALA T 302      -56.79     80.62                                   
REMARK 500    THR T 303       34.82   -143.28                                   
REMARK 500    GLN T 306      177.92    -52.02                                   
REMARK 500    PHE T 310      -71.03    -53.71                                   
REMARK 500    ASN T 312      -39.68   -161.10                                   
REMARK 500    GLU T 326      -85.85   -121.26                                   
REMARK 500    LEU T 327      143.67    -33.20                                   
REMARK 500    LYS T 328      -69.64    -21.12                                   
REMARK 500    LEU T 329      -42.24     68.40                                   
REMARK 500    ARG T 330      -58.77     68.04                                   
REMARK 500    LYS T 331      -36.05    -30.27                                   
REMARK 500    SER T 340      106.54    -58.51                                   
REMARK 500    LYS T 357      -82.87     63.76                                   
REMARK 500    LEU T 363      102.59    -59.09                                   
REMARK 500    THR T 373       84.04   -162.69                                   
REMARK 500    SER T 375     -125.05   -128.92                                   
REMARK 500    ARG T 376       81.33    -59.43                                   
REMARK 500    LEU T 396       21.07    -70.43                                   
REMARK 500    SER T 400     -133.70     68.71                                   
REMARK 500    VAL T 401      125.74     80.58                                   
REMARK 500    LYS T 410      102.60    -55.80                                   
REMARK 500    VAL T 411     -109.68     32.24                                   
REMARK 500    ASP T 412       47.64    -66.48                                   
REMARK 500    GLN T 413      -91.28   -103.11                                   
REMARK 500    MET T 428      170.41    -55.93                                   
REMARK 500    ALA T 461       28.16    -75.16                                   
REMARK 500    TYR U   9       79.47    -68.76                                   
REMARK 500    LYS U  10      164.45    -49.71                                   
REMARK 500    TRP U  13     -172.21    -64.47                                   
REMARK 500    ASP U  14      -74.51     71.38                                   
REMARK 500    TYR U  16      -97.38    -58.80                                   
REMARK 500    ASP U  17     -116.69     44.33                                   
REMARK 500    ASP U  18       -9.02     60.75                                   
REMARK 500    LYS U  19      -25.65     68.05                                   
REMARK 500    GLN U  20      -71.17    -91.51                                   
REMARK 500    VAL U  24        5.44    -64.87                                   
REMARK 500    PHE U  25      -37.93   -156.73                                   
REMARK 500    ARG U  30       79.03    -66.57                                   
REMARK 500    PHE U  31      -64.09    170.23                                   
REMARK 500    PHE U  34      -32.28    -35.16                                   
REMARK 500    ASN U  37       35.61    -75.92                                   
REMARK 500    GLU U  43       26.44     15.03                                   
REMARK 500    GLU U  53       16.76     57.99                                   
REMARK 500    TYR U  57      145.02     66.25                                   
REMARK 500    ARG U  58      -73.27   -176.73                                   
REMARK 500    ASN U  59      -89.72     42.13                                   
REMARK 500    ILE U  60      -81.44     25.81                                   
REMARK 500    ASP U  62       67.18    -67.59                                   
REMARK 500    ALA U  65      -52.84     70.27                                   
REMARK 500    THR U  69       74.24     45.45                                   
REMARK 500    LEU U  70      100.92    -48.59                                   
REMARK 500    LYS U  71     -168.94   -163.79                                   
REMARK 500    GLU U  72      139.96    -34.34                                   
REMARK 500    ALA U 104      148.83   -171.75                                   
REMARK 500    LEU U 113      139.22    -34.84                                   
REMARK 500    LYS U 114     -168.64    -73.24                                   
REMARK 500    THR U 122       82.73     54.88                                   
REMARK 500    ASP U 123      -96.18     63.08                                   
REMARK 500    LEU U 124      159.10    -46.35                                   
REMARK 500    HIS U 130       92.96   -168.94                                   
REMARK 500    TYR U 131      150.22    -46.76                                   
REMARK 500    LYS U 136      -54.25     33.61                                   
REMARK 500    TYR U 138       29.11    -73.02                                   
REMARK 500    VAL U 141     -126.18    -76.66                                   
REMARK 500    THR U 142      -54.55     -2.88                                   
REMARK 500    HIS U 148     -162.19   -128.66                                   
REMARK 500    CYS U 162       86.11   -156.11                                   
REMARK 500    ASP U 167       -5.22    -59.58                                   
REMARK 500    LYS U 188      108.66     40.24                                   
REMARK 500    ALA U 190      -35.66    -35.06                                   
REMARK 500    SER U 191      107.62    175.48                                   
REMARK 500    ILE U 194       -7.80   -152.66                                   
REMARK 500    GLU U 195     -174.57    -48.97                                   
REMARK 500    LEU U 199       93.15     75.99                                   
REMARK 500    LEU U 202      134.86   -174.45                                   
REMARK 500    SER U 205       52.12     31.66                                   
REMARK 500    PRO U 207     -128.63   -140.28                                   
REMARK 500    LYS U 209       11.08     52.13                                   
REMARK 500    GLU U 212     -148.05     57.41                                   
REMARK 500    GLU U 213       94.94     75.33                                   
REMARK 500    LYS U 214      -66.84    -15.58                                   
REMARK 500    TYR U 229     -137.51     60.52                                   
REMARK 500    ASP U 230       37.76   -179.77                                   
REMARK 500    GLU U 234     -152.42    -71.88                                   
REMARK 500    ASP U 235      -40.15     68.73                                   
REMARK 500    SER U 238       40.69   -108.32                                   
REMARK 500    GLU U 242       94.83   -162.07                                   
REMARK 500    ASP U 265      107.46    -52.69                                   
REMARK 500    ASP U 266      -28.68     62.84                                   
REMARK 500    GLU U 279       30.92    -80.11                                   
REMARK 500    ASN U 282       83.79     62.26                                   
REMARK 500    ALA U 302      -57.06     80.14                                   
REMARK 500    THR U 303       34.82   -143.41                                   
REMARK 500    GLN U 306      177.59    -50.92                                   
REMARK 500    PHE U 310      -70.85    -52.93                                   
REMARK 500    ASN U 312      -39.42   -163.33                                   
REMARK 500    GLU U 326      -86.13   -120.93                                   
REMARK 500    LEU U 327      143.01    -32.39                                   
REMARK 500    LYS U 328      -69.08    -20.97                                   
REMARK 500    LEU U 329      -43.13     68.27                                   
REMARK 500    ARG U 330      -58.99     68.59                                   
REMARK 500    LYS U 331      -35.96    -29.95                                   
REMARK 500    SER U 340      109.01    -59.65                                   
REMARK 500    LYS U 357      -83.29     64.19                                   
REMARK 500    LEU U 363      101.60    -59.28                                   
REMARK 500    THR U 373       84.51   -163.31                                   
REMARK 500    SER U 375     -124.56   -129.18                                   
REMARK 500    ARG U 376       81.58    -60.78                                   
REMARK 500    SER U 400     -131.97     67.74                                   
REMARK 500    VAL U 401      127.20     78.24                                   
REMARK 500    LYS U 410      104.37    -54.58                                   
REMARK 500    VAL U 411     -108.81     30.69                                   
REMARK 500    ASP U 412       46.65    -67.19                                   
REMARK 500    GLN U 413      -89.96   -101.97                                   
REMARK 500    MET U 428      170.84    -57.10                                   
REMARK 500    ALA U 461       26.58    -76.52                                   
REMARK 500    LYS V   7      152.88     64.62                                   
REMARK 500    ASN V  11     -151.36     44.24                                   
REMARK 500    TRP V  13     -171.64    -63.62                                   
REMARK 500    ASP V  14      -74.87     71.65                                   
REMARK 500    TYR V  16      -97.49    -59.97                                   
REMARK 500    ASP V  17     -116.00     44.32                                   
REMARK 500    ASP V  18       -9.18     60.56                                   
REMARK 500    LYS V  19      -26.21     68.46                                   
REMARK 500    GLN V  20      -72.06    -91.39                                   
REMARK 500    VAL V  24        4.83    -64.18                                   
REMARK 500    PHE V  25      -38.28   -156.24                                   
REMARK 500    ARG V  30       79.88    -68.83                                   
REMARK 500    PHE V  31      -66.28    170.12                                   
REMARK 500    PHE V  34      -33.15    -34.75                                   
REMARK 500    ASN V  37       35.55    -75.89                                   
REMARK 500    GLU V  43       26.62     15.83                                   
REMARK 500    GLU V  53       15.96     59.41                                   
REMARK 500    TYR V  57      144.93     67.27                                   
REMARK 500    ARG V  58      -74.43   -176.71                                   
REMARK 500    ASN V  59      -89.93     43.55                                   
REMARK 500    ILE V  60      -80.88     26.11                                   
REMARK 500    ASP V  62       66.44    -67.25                                   
REMARK 500    ALA V  65      -54.06     71.55                                   
REMARK 500    THR V  69       74.06     45.07                                   
REMARK 500    LEU V  70      101.77    -48.52                                   
REMARK 500    LYS V  71     -168.39   -164.16                                   
REMARK 500    GLU V  72      140.25    -34.75                                   
REMARK 500    ALA V 104      147.29   -172.31                                   
REMARK 500    LEU V 113      138.58    -36.64                                   
REMARK 500    LYS V 114     -168.54    -73.53                                   
REMARK 500    THR V 122       82.63     55.42                                   
REMARK 500    ASP V 123      -95.79     62.68                                   
REMARK 500    LEU V 124      160.03    -46.98                                   
REMARK 500    HIS V 130       91.95   -171.11                                   
REMARK 500    TYR V 131      150.80    -45.46                                   
REMARK 500    LYS V 136      -53.96     32.42                                   
REMARK 500    TYR V 138       30.90    -74.34                                   
REMARK 500    VAL V 141     -124.47    -75.16                                   
REMARK 500    THR V 142      -53.56     -4.34                                   
REMARK 500    HIS V 148     -162.47   -127.56                                   
REMARK 500    CYS V 162       86.05   -156.56                                   
REMARK 500    ASP V 167       -6.03    -59.28                                   
REMARK 500    LYS V 188      108.31     39.16                                   
REMARK 500    ALA V 190      -35.63    -36.87                                   
REMARK 500    SER V 191      106.91    176.30                                   
REMARK 500    ILE V 194       -7.33   -152.19                                   
REMARK 500    GLU V 195     -175.07    -49.48                                   
REMARK 500    LEU V 199       92.44     78.32                                   
REMARK 500    LEU V 202      134.59   -174.31                                   
REMARK 500    SER V 205       52.71     32.30                                   
REMARK 500    PRO V 207     -126.29   -134.01                                   
REMARK 500    LYS V 209       11.59     51.72                                   
REMARK 500    GLU V 212     -148.61     58.10                                   
REMARK 500    GLU V 213       94.97     76.13                                   
REMARK 500    LYS V 214      -67.31    -15.23                                   
REMARK 500    TYR V 229     -137.97     60.55                                   
REMARK 500    ASP V 230       37.64    179.34                                   
REMARK 500    GLU V 234     -153.43    -73.26                                   
REMARK 500    ASP V 235      -39.23     69.85                                   
REMARK 500    SER V 238       42.93   -108.00                                   
REMARK 500    GLU V 242       94.12   -162.30                                   
REMARK 500    ASP V 265      105.84    -52.52                                   
REMARK 500    ASP V 266      -28.20     63.87                                   
REMARK 500    GLU V 279       31.39    -80.86                                   
REMARK 500    ASN V 282       84.30     62.66                                   
REMARK 500    ALA V 302      -56.30     79.86                                   
REMARK 500    THR V 303       34.79   -143.52                                   
REMARK 500    GLN V 306      178.10    -50.26                                   
REMARK 500    PHE V 310      -70.15    -54.99                                   
REMARK 500    ASN V 312      -40.41   -161.64                                   
REMARK 500    GLU V 326      -84.06   -121.71                                   
REMARK 500    LEU V 327      142.67    -33.96                                   
REMARK 500    LYS V 328      -69.12    -20.81                                   
REMARK 500    LEU V 329      -42.32     68.22                                   
REMARK 500    ARG V 330      -58.07     67.93                                   
REMARK 500    LYS V 331      -36.17    -31.31                                   
REMARK 500    SER V 340      107.02    -58.90                                   
REMARK 500    LYS V 357      -82.72     63.80                                   
REMARK 500    THR V 373       84.22   -163.18                                   
REMARK 500    SER V 375     -123.83   -128.50                                   
REMARK 500    ARG V 376       82.56    -60.50                                   
REMARK 500    LYS V 378       18.49     59.35                                   
REMARK 500    SER V 400     -134.01     67.92                                   
REMARK 500    VAL V 401      126.61     80.58                                   
REMARK 500    LYS V 410      103.12    -54.69                                   
REMARK 500    VAL V 411     -109.65     31.96                                   
REMARK 500    ASP V 412       47.44    -67.14                                   
REMARK 500    GLN V 413      -91.99   -102.39                                   
REMARK 500    MET V 428      170.15    -55.97                                   
REMARK 500    ALA V 461       28.12    -74.46                                   
REMARK 500    TRP W  13     -172.04    -66.11                                   
REMARK 500    ASP W  14      -75.35     71.45                                   
REMARK 500    TYR W  16      -98.00    -58.50                                   
REMARK 500    ASP W  17     -116.38     44.35                                   
REMARK 500    ASP W  18       -8.72     60.59                                   
REMARK 500    LYS W  19      -26.32     68.13                                   
REMARK 500    GLN W  20      -71.58    -90.98                                   
REMARK 500    VAL W  24        5.96    -64.62                                   
REMARK 500    PHE W  25      -39.30   -157.24                                   
REMARK 500    ARG W  30       79.79    -66.98                                   
REMARK 500    PHE W  31      -65.24    170.04                                   
REMARK 500    PHE W  34      -32.30    -34.65                                   
REMARK 500    ASN W  37       36.16    -76.59                                   
REMARK 500    GLU W  43       26.97     15.34                                   
REMARK 500    GLU W  53       16.62     59.40                                   
REMARK 500    TYR W  57      145.10     67.13                                   
REMARK 500    ARG W  58      -74.50   -177.07                                   
REMARK 500    ASN W  59      -90.23     42.99                                   
REMARK 500    ILE W  60      -81.80     26.36                                   
REMARK 500    ASP W  62       66.13    -67.13                                   
REMARK 500    ALA W  65      -52.52     70.58                                   
REMARK 500    THR W  69       74.56     45.21                                   
REMARK 500    LEU W  70      100.83    -48.79                                   
REMARK 500    LYS W  71     -168.60   -163.66                                   
REMARK 500    GLU W  72      139.86    -34.90                                   
REMARK 500    ALA W 104      148.52   -172.36                                   
REMARK 500    LEU W 113      138.86    -37.08                                   
REMARK 500    LYS W 114     -167.76    -73.10                                   
REMARK 500    THR W 122       82.72     55.52                                   
REMARK 500    ASP W 123      -96.56     63.94                                   
REMARK 500    LEU W 124      157.74    -46.64                                   
REMARK 500    HIS W 130       94.74   -168.37                                   
REMARK 500    LYS W 136      -53.66     32.91                                   
REMARK 500    TYR W 138       29.84    -74.21                                   
REMARK 500    VAL W 141     -124.08    -76.53                                   
REMARK 500    THR W 142      -53.39     -4.92                                   
REMARK 500    HIS W 148     -162.46   -127.66                                   
REMARK 500    CYS W 162       86.75   -156.69                                   
REMARK 500    ASP W 167       -6.40    -59.41                                   
REMARK 500    LEU W 186      -30.02   -132.21                                   
REMARK 500    LYS W 188      109.18     38.85                                   
REMARK 500    ALA W 190      -36.27    -36.92                                   
REMARK 500    SER W 191      106.97    176.87                                   
REMARK 500    ILE W 194       -6.51   -152.56                                   
REMARK 500    GLU W 195     -174.64    -49.99                                   
REMARK 500    LEU W 199       92.97     75.09                                   
REMARK 500    LEU W 202      134.78   -174.68                                   
REMARK 500    SER W 205       52.71     31.21                                   
REMARK 500    PRO W 207     -125.91   -134.07                                   
REMARK 500    LYS W 209       11.12     51.91                                   
REMARK 500    GLU W 212     -148.95     57.79                                   
REMARK 500    GLU W 213       95.24     76.18                                   
REMARK 500    LYS W 214      -67.04    -15.60                                   
REMARK 500    TYR W 229     -137.11     59.57                                   
REMARK 500    ASP W 230       37.11    179.61                                   
REMARK 500    GLU W 234     -153.02    -72.17                                   
REMARK 500    ASP W 235      -39.30     69.46                                   
REMARK 500    SER W 238       42.72   -108.28                                   
REMARK 500    GLU W 242       94.98   -163.76                                   
REMARK 500    ASP W 265      104.48    -51.32                                   
REMARK 500    ASP W 266      -27.74     63.38                                   
REMARK 500    GLU W 279       30.87    -81.74                                   
REMARK 500    ASN W 282       84.22     62.65                                   
REMARK 500    ASP W 293     -162.39   -129.41                                   
REMARK 500    SER W 299       33.44     70.45                                   
REMARK 500    ALA W 302      -57.77     81.21                                   
REMARK 500    THR W 303       34.64   -142.65                                   
REMARK 500    GLN W 306      178.39    -50.60                                   
REMARK 500    PHE W 310      -71.24    -53.73                                   
REMARK 500    ASN W 312      -40.24   -161.45                                   
REMARK 500    GLU W 326      -85.84   -121.19                                   
REMARK 500    LEU W 327      143.25    -33.02                                   
REMARK 500    LYS W 328      -68.54    -21.42                                   
REMARK 500    LEU W 329      -42.54     68.23                                   
REMARK 500    ARG W 330      -58.87     68.41                                   
REMARK 500    LYS W 331      -36.62    -30.52                                   
REMARK 500    LYS W 357      -81.74     64.24                                   
REMARK 500    LEU W 363      101.26    -59.93                                   
REMARK 500    THR W 373       83.66   -162.12                                   
REMARK 500    SER W 375     -125.44   -129.20                                   
REMARK 500    ARG W 376       81.66    -59.27                                   
REMARK 500    SER W 400     -133.11     67.75                                   
REMARK 500    VAL W 401      126.75     80.23                                   
REMARK 500    LYS W 410      103.59    -54.86                                   
REMARK 500    VAL W 411     -109.74     31.68                                   
REMARK 500    ASP W 412       47.05    -66.53                                   
REMARK 500    GLN W 413      -91.14   -102.22                                   
REMARK 500    MET W 428      170.43    -56.77                                   
REMARK 500    ALA W 461       26.77    -75.38                                   
REMARK 500    LYS X  10      127.49     66.84                                   
REMARK 500    TRP X  13     -171.85    -64.86                                   
REMARK 500    ASP X  14      -75.54     71.67                                   
REMARK 500    TYR X  16      -97.32    -60.12                                   
REMARK 500    ASP X  17     -117.41     44.42                                   
REMARK 500    ASP X  18       -8.97     61.71                                   
REMARK 500    LYS X  19      -25.23     67.64                                   
REMARK 500    GLN X  20      -71.80    -91.69                                   
REMARK 500    VAL X  24        6.49    -64.90                                   
REMARK 500    PHE X  25      -38.54   -157.25                                   
REMARK 500    ARG X  30       79.62    -67.92                                   
REMARK 500    PHE X  31      -65.18    170.05                                   
REMARK 500    LYS X  32      -70.59    -58.61                                   
REMARK 500    PHE X  34      -32.73    -35.00                                   
REMARK 500    ASN X  37       34.70    -75.75                                   
REMARK 500    GLU X  43       27.38     14.60                                   
REMARK 500    GLU X  53       16.07     58.45                                   
REMARK 500    TYR X  57      144.73     65.80                                   
REMARK 500    ARG X  58      -73.35   -176.29                                   
REMARK 500    ASN X  59      -90.42     41.93                                   
REMARK 500    ILE X  60      -81.18     26.73                                   
REMARK 500    ASP X  62       67.10    -67.50                                   
REMARK 500    ALA X  65      -53.22     71.44                                   
REMARK 500    THR X  69       74.31     45.55                                   
REMARK 500    LEU X  70      101.07    -48.88                                   
REMARK 500    LYS X  71     -168.14   -164.45                                   
REMARK 500    GLU X  72      140.25    -35.21                                   
REMARK 500    ALA X 104      148.89   -172.97                                   
REMARK 500    LEU X 113      140.55    -37.31                                   
REMARK 500    LYS X 114     -169.30    -74.26                                   
REMARK 500    THR X 122       83.30     55.28                                   
REMARK 500    ASP X 123      -97.81     62.61                                   
REMARK 500    LEU X 124      158.73    -44.93                                   
REMARK 500    HIS X 130       95.05   -169.05                                   
REMARK 500    LYS X 136      -52.94     32.75                                   
REMARK 500    TYR X 138       30.55    -73.39                                   
REMARK 500    VAL X 141     -125.41    -76.82                                   
REMARK 500    THR X 142      -54.44     -2.78                                   
REMARK 500    HIS X 148     -161.53   -126.75                                   
REMARK 500    CYS X 162       85.17   -157.05                                   
REMARK 500    ASP X 167       -5.30    -59.71                                   
REMARK 500    LYS X 188      108.61     39.38                                   
REMARK 500    ALA X 190      -36.53    -36.80                                   
REMARK 500    SER X 191      106.44    177.30                                   
REMARK 500    ILE X 194       -7.79   -152.35                                   
REMARK 500    GLU X 195     -174.75    -48.53                                   
REMARK 500    LEU X 199       92.34     75.88                                   
REMARK 500    LEU X 202      134.82   -174.60                                   
REMARK 500    SER X 205       52.81     30.92                                   
REMARK 500    PRO X 207     -125.71   -132.48                                   
REMARK 500    LYS X 209       11.50     51.76                                   
REMARK 500    GLU X 212     -148.35     57.71                                   
REMARK 500    GLU X 213       94.97     75.57                                   
REMARK 500    LYS X 214      -65.70    -15.61                                   
REMARK 500    TYR X 229     -137.60     60.11                                   
REMARK 500    ASP X 230       37.63    179.15                                   
REMARK 500    GLU X 234     -151.56    -71.76                                   
REMARK 500    ASP X 235      -39.66     68.54                                   
REMARK 500    SER X 238       43.44   -108.31                                   
REMARK 500    GLU X 242       94.43   -162.65                                   
REMARK 500    ASP X 265      104.93    -51.45                                   
REMARK 500    ASP X 266      -27.45     63.99                                   
REMARK 500    GLU X 279       30.75    -80.53                                   
REMARK 500    ASN X 282       83.87     62.85                                   
REMARK 500    ALA X 302      -57.08     79.95                                   
REMARK 500    THR X 303       36.09   -143.40                                   
REMARK 500    GLN X 306      179.46    -50.08                                   
REMARK 500    PHE X 310      -70.57    -54.54                                   
REMARK 500    ASN X 312      -40.44   -162.63                                   
REMARK 500    GLU X 326      -85.72   -121.02                                   
REMARK 500    LEU X 327      142.82    -32.48                                   
REMARK 500    LYS X 328      -69.33    -20.99                                   
REMARK 500    LEU X 329      -42.75     68.53                                   
REMARK 500    ARG X 330      -58.09     68.28                                   
REMARK 500    LYS X 331      -37.18    -30.81                                   
REMARK 500    LYS X 357      -83.43     62.99                                   
REMARK 500    LEU X 363      101.76    -58.76                                   
REMARK 500    THR X 373       84.94   -163.03                                   
REMARK 500    SER X 375     -123.62   -127.36                                   
REMARK 500    ARG X 376       81.72    -61.09                                   
REMARK 500    LEU X 396       20.05    -72.14                                   
REMARK 500    SER X 400     -134.22     69.40                                   
REMARK 500    VAL X 401      126.43     80.04                                   
REMARK 500    LYS X 410      103.80    -55.15                                   
REMARK 500    VAL X 411     -108.92     31.28                                   
REMARK 500    ASP X 412       47.20    -66.92                                   
REMARK 500    GLN X 413      -91.12   -103.09                                   
REMARK 500    MET X 428      170.26    -56.40                                   
REMARK 500    ALA X 461       26.80    -74.85                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    TYR K   9         0.07    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH E6016        DISTANCE =  5.20 ANGSTROMS                       
REMARK 525    HOH K6106        DISTANCE =  5.08 ANGSTROMS                       
REMARK 525    HOH P6124        DISTANCE =  5.25 ANGSTROMS                       
REMARK 525    HOH N6129        DISTANCE =  5.20 ANGSTROMS                       
REMARK 525    HOH I6138        DISTANCE =  5.94 ANGSTROMS                       
REMARK 525    HOH W6167        DISTANCE =  5.13 ANGSTROMS                       
REMARK 525    HOH V6168        DISTANCE =  5.92 ANGSTROMS                       
REMARK 525    HOH H6143        DISTANCE =  5.76 ANGSTROMS                       
REMARK 525    HOH K6149        DISTANCE =  5.58 ANGSTROMS                       
REMARK 525    HOH K6153        DISTANCE =  6.45 ANGSTROMS                       
REMARK 525    HOH T6171        DISTANCE =  5.29 ANGSTROMS                       
REMARK 525    HOH E6141        DISTANCE =  5.93 ANGSTROMS                       
REMARK 525    HOH Q6166        DISTANCE =  5.34 ANGSTROMS                       
REMARK 525    HOH F6150        DISTANCE =  5.29 ANGSTROMS                       
REMARK 525    HOH B6143        DISTANCE =  5.26 ANGSTROMS                       
REMARK 525    HOH K6163        DISTANCE =  6.62 ANGSTROMS                       
REMARK 525    HOH I6160        DISTANCE =  5.87 ANGSTROMS                       
REMARK 525    HOH E6152        DISTANCE =  5.70 ANGSTROMS                       
REMARK 525    HOH F6154        DISTANCE =  5.03 ANGSTROMS                       
REMARK 525    HOH J6165        DISTANCE =  5.30 ANGSTROMS                       
REMARK 525    HOH A6147        DISTANCE =  5.11 ANGSTROMS                       
REMARK 525    HOH M6175        DISTANCE =  6.19 ANGSTROMS                       
REMARK 525    HOH D6163        DISTANCE =  5.55 ANGSTROMS                       
REMARK 525    HOH F6173        DISTANCE =  5.41 ANGSTROMS                       
REMARK 525    HOH D6170        DISTANCE =  5.22 ANGSTROMS                       
REMARK 525    HOH N6196        DISTANCE =  5.24 ANGSTROMS                       
REMARK 525    HOH D6177        DISTANCE =  5.30 ANGSTROMS                       
REMARK 525    HOH L6194        DISTANCE =  5.45 ANGSTROMS                       
REMARK 525    HOH O6202        DISTANCE =  5.09 ANGSTROMS                       
REMARK 525    HOH A6174        DISTANCE =  5.73 ANGSTROMS                       
REMARK 525    HOH Q6207        DISTANCE =  5.63 ANGSTROMS                       
REMARK 525    HOH Q6209        DISTANCE =  5.37 ANGSTROMS                       
REMARK 525    HOH W6221        DISTANCE =  5.97 ANGSTROMS                       
REMARK 525    HOH L6202        DISTANCE =  6.76 ANGSTROMS                       
REMARK 525    HOH F6191        DISTANCE =  5.61 ANGSTROMS                       
REMARK 525    HOH A6184        DISTANCE =  6.57 ANGSTROMS                       
REMARK 525    HOH J6204        DISTANCE =  5.84 ANGSTROMS                       
REMARK 525    HOH N6213        DISTANCE =  5.13 ANGSTROMS                       
REMARK 525    HOH D6195        DISTANCE =  5.11 ANGSTROMS                       
REMARK 525    HOH K6210        DISTANCE =  5.17 ANGSTROMS                       
REMARK 525    HOH U6230        DISTANCE =  6.68 ANGSTROMS                       
REMARK 525    HOH A6194        DISTANCE =  5.30 ANGSTROMS                       
REMARK 525    HOH D6200        DISTANCE =  5.01 ANGSTROMS                       
REMARK 525    HOH F6205        DISTANCE =  5.02 ANGSTROMS                       
REMARK 525    HOH K6218        DISTANCE =  6.30 ANGSTROMS                       
REMARK 525    HOH J6218        DISTANCE =  6.68 ANGSTROMS                       
REMARK 525    HOH I6218        DISTANCE =  6.48 ANGSTROMS                       
REMARK 525    HOH O6233        DISTANCE =  6.21 ANGSTROMS                       
REMARK 525    HOH F6216        DISTANCE =  5.53 ANGSTROMS                       
REMARK 525    HOH U6248        DISTANCE =  6.13 ANGSTROMS                       
REMARK 525    HOH T6249        DISTANCE =  6.03 ANGSTROMS                       
REMARK 525    HOH L6234        DISTANCE =  5.21 ANGSTROMS                       
REMARK 525    HOH L6236        DISTANCE =  6.29 ANGSTROMS                       
REMARK 525    HOH D6220        DISTANCE =  5.94 ANGSTROMS                       
REMARK 525    HOH C6223        DISTANCE =  6.20 ANGSTROMS                       
REMARK 525    HOH N6246        DISTANCE =  6.27 ANGSTROMS                       
REMARK 525    HOH D6232        DISTANCE =  7.02 ANGSTROMS                       
REMARK 525    HOH J6251        DISTANCE =  5.62 ANGSTROMS                       
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620  (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;              
REMARK 620  SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                            
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN A6001  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU A 296   OE2                                                    
REMARK 620 2 HOH A6108   O    57.7                                              
REMARK 620 3 GLU A 296   OE1  52.2 109.1                                        
REMARK 620 4  MN A6002  MN   119.6 142.6  84.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN A6002  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 342   OD2                                                    
REMARK 620 2 ASP A 342   OD1  56.3                                              
REMARK 620 3 ASP A 265   OD1  82.0 138.2                                        
REMARK 620 4 HIS A 105   NE2  94.6 100.3  82.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN B6003  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU B 296   OE1                                                    
REMARK 620 2 GLU B 296   OE2  56.1                                              
REMARK 620 3 HIS B 441   NE2  66.0  70.8                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN B6004  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP B 265   OD1                                                    
REMARK 620 2 ASP B 342   OD2  85.7                                              
REMARK 620 3 HIS B 105   NE2  84.8  98.7                                        
REMARK 620 4 ASP B 342   OD1 143.4  57.8 102.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN C6005  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU C 296   OE1                                                    
REMARK 620 2 HIS C 441   NE2  65.9                                              
REMARK 620 3 GLU C 296   OE2  56.0  69.6                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN C6006  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS C 105   NE2                                                    
REMARK 620 2 ASP C 342   OD1  87.9                                              
REMARK 620 3 ASP C 342   OD2  89.3  55.3                                        
REMARK 620 4 ASP C 265   OD1  80.5 142.7  89.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN D6007  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU D 296   OE2                                                    
REMARK 620 2 HIS D 441   NE2  71.7                                              
REMARK 620 3 GLU D 296   OE1  59.7  68.8                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN D6008  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS D 105   NE2                                                    
REMARK 620 2 ASP D 342   OD1  90.0                                              
REMARK 620 3 ASP D 342   OD2  92.5  56.4                                        
REMARK 620 4 ASP D 265   OD1  85.3 145.9  90.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN E6009  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU E 296   OE2                                                    
REMARK 620 2 GLU E 296   OE1  51.1                                              
REMARK 620 3 HIS E 441   NE2  63.7  66.7                                        
REMARK 620 4 HOH E6203   O    69.0 108.8 119.4                                  
REMARK 620 5  MN E6010  MN   111.9  74.8 131.6  99.7                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN E6010  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS E 105   NE2                                                    
REMARK 620 2 ASP E 265   OD1  90.3                                              
REMARK 620 3 ASP E 342   OD1  89.1 146.3                                        
REMARK 620 4 ASP E 342   OD2  96.2  92.6  54.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN F6011  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU F 296   OE1                                                    
REMARK 620 2 GLU F 296   OE2  50.1                                              
REMARK 620 3 HIS F 441   NE2  69.8  69.1                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN F6012  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP F 342   OD1                                                    
REMARK 620 2 HOH F6021   O    76.8                                              
REMARK 620 3 HIS F 105   NE2  86.4 157.1                                        
REMARK 620 4 ASP F 265   OD1 142.9 102.1  81.9                                  
REMARK 620 5 ASP F 342   OD2  54.3  68.5  89.1  90.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN G6013  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH G6040   O                                                      
REMARK 620 2 GLU G 296   OE1  99.7                                              
REMARK 620 3  MN G6014  MN   138.5  85.6                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN G6014  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS G 105   NE2                                                    
REMARK 620 2 ASP G 265   OD1  91.7                                              
REMARK 620 3 ASP G 342   OD2 107.7  97.6                                        
REMARK 620 4 ASP G 342   OD1 100.3 156.5  59.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN H6015  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS H 441   NE2                                                    
REMARK 620 2 GLU H 296   OE1  64.3                                              
REMARK 620 3 GLU H 296   OE2  64.2  52.9                                        
REMARK 620 4  MN H6016  MN   132.1  83.0 122.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN H6016  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP H 265   OD1                                                    
REMARK 620 2 HIS H 105   NE2  78.4                                              
REMARK 620 3 ASP H 342   OD1 146.4  87.3                                        
REMARK 620 4 ASP H 342   OD2  89.9  90.2  59.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN I6017  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU I 296   OE2                                                    
REMARK 620 2 GLU I 296   OE1  53.2                                              
REMARK 620 3 HIS I 441   NE2  64.2  67.4                                        
REMARK 620 4  MN I6018  MN   115.0  81.3 140.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN I6018  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP I 265   OD1                                                    
REMARK 620 2 ASP I 342   OD2  81.9                                              
REMARK 620 3 HOH I6115   O    97.5  66.2                                        
REMARK 620 4 HIS I 105   NE2  78.4  94.9 161.1                                  
REMARK 620 5 ASP I 342   OD1 139.2  57.5  71.4  99.5                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN J6019  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH J6023   O                                                      
REMARK 620 2 GLU J 296   OE1 116.1                                              
REMARK 620 3 GLU J 296   OE2  67.4  53.9                                        
REMARK 620 4 HIS J 441   NE2 112.9  70.4  70.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN J6020  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS J 105   NE2                                                    
REMARK 620 2 ASP J 342   OD1  93.6                                              
REMARK 620 3 ASP J 342   OD2  95.5  59.3                                        
REMARK 620 4 ASP J 265   OD1  82.5 149.8  91.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN K6021  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU K 296   OE1                                                    
REMARK 620 2 GLU K 296   OE2  52.1                                              
REMARK 620 3 HIS K 441   NE2  69.9  69.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN K6022  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS K 105   NE2                                                    
REMARK 620 2 ASP K 265   OD1  76.8                                              
REMARK 620 3 ASP K 342   OD2  87.6  78.8                                        
REMARK 620 4 ASP K 342   OD1  93.0 133.9  55.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN L6023  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP L 265   OD2                                                    
REMARK 620 2 HIS L 441   NE2  73.8                                              
REMARK 620 3 GLU L 296   OE1  75.5  74.6                                        
REMARK 620 4 GLU L 296   OE2 123.0  69.6  53.7                                  
REMARK 620 5 HOH L6116   O   150.6 132.4 119.9  83.7                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN L6024  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP L 342   OD2                                                    
REMARK 620 2 ASP L 342   OD1  59.4                                              
REMARK 620 3 HIS L 105   NE2  93.8  94.1                                        
REMARK 620 4 ASP L 265   OD1  89.5 148.1  79.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN M6025  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU M 296   OE2                                                    
REMARK 620 2 GLU M 296   OE1  51.7                                              
REMARK 620 3 HIS M 441   NE2  66.4  66.5                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN M6026  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP M 342   OD2                                                    
REMARK 620 2 ASP M 265   OD1  86.3                                              
REMARK 620 3 HIS M 105   NE2  94.5  84.0                                        
REMARK 620 4 ASP M 342   OD1  56.8 143.1  97.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN N6027  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP N 265   OD2                                                    
REMARK 620 2 GLU N 296   OE1  82.0                                              
REMARK 620 3 HIS N 441   NE2  78.9  72.9                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN N6028  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP N 342   OD2                                                    
REMARK 620 2 HIS N 105   NE2  95.1                                              
REMARK 620 3 ASP N 265   OD1  86.7  80.3                                        
REMARK 620 4 ASP N 342   OD1  60.0  98.4 146.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN O6029  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS O 441   NE2                                                    
REMARK 620 2 GLU O 296   OE2  71.9                                              
REMARK 620 3 GLU O 296   OE1  71.7  56.1                                        
REMARK 620 4 HOH O6151   O   163.2  96.1 111.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN O6030  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS O 105   NE2                                                    
REMARK 620 2 ASP O 342   OD1  93.1                                              
REMARK 620 3 HOH O6151   O   134.1  85.1                                        
REMARK 620 4 ASP O 265   OD1  81.1 128.3 133.8                                  
REMARK 620 5 ASP O 342   OD2  85.8  51.9 125.4  76.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN P6031  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU P 296   OE2                                                    
REMARK 620 2 HIS P 441   NE2  67.7                                              
REMARK 620 3 GLU P 296   OE1  54.0  65.6                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN P6032  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS P 105   NE2                                                    
REMARK 620 2 ASP P 342   OD1  97.3                                              
REMARK 620 3 ASP P 265   OD1  84.2 130.5                                        
REMARK 620 4 ASP P 342   OD2  91.4  51.6  78.9                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN Q6033  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS Q 441   NE2                                                    
REMARK 620 2 ASP Q 265   OD2  78.1                                              
REMARK 620 3 GLU Q 296   OE1  75.8  75.5                                        
REMARK 620 4 GLU Q 296   OE2  70.2 123.8  52.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN Q6034  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS Q 105   NE2                                                    
REMARK 620 2 ASP Q 342   OD2  93.6                                              
REMARK 620 3 ASP Q 265   OD1  78.5  84.8                                        
REMARK 620 4 ASP Q 342   OD1  98.3  59.6 144.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN R6035  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH R6197   O                                                      
REMARK 620 2 GLU R 296   OE1 109.2                                              
REMARK 620 3 HIS R 441   NE2 172.0  67.2                                        
REMARK 620 4 GLU R 296   OE2 113.0  56.4  71.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN R6036  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH R6197   O                                                      
REMARK 620 2 ASP R 342   OD2 112.3                                              
REMARK 620 3 HIS R 105   NE2 107.8  84.3                                        
REMARK 620 4 ASP R 265   OD1 157.0  89.4  80.6                                  
REMARK 620 5 ASP R 342   OD1  65.9  51.5  78.8 137.1                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN S6037  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU S 296   OE2                                                    
REMARK 620 2 HIS S 441   NE2  66.0                                              
REMARK 620 3 HOH S6121   O    69.0 125.5                                        
REMARK 620 4 GLU S 296   OE1  50.2  68.6 103.4                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN S6038  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP S 342   OD1                                                    
REMARK 620 2 ASP S 342   OD2  54.5                                              
REMARK 620 3 ASP S 265   OD1 148.5  94.0                                        
REMARK 620 4 HIS S 105   NE2  93.2 100.2  94.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN T6039  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU T 296   OE2                                                    
REMARK 620 2 HIS T 441   NE2  68.1                                              
REMARK 620 3 GLU T 296   OE1  51.4  70.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN T6040  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP T 265   OD1                                                    
REMARK 620 2 HIS T 105   NE2  81.5                                              
REMARK 620 3 ASP T 342   OD1 145.2  92.9                                        
REMARK 620 4 ASP T 342   OD2  87.8  95.1  58.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN U6041  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS U 441   NE2                                                    
REMARK 620 2 GLU U 296   OE1  61.7                                              
REMARK 620 3 HOH U6049   O   103.3 103.5                                        
REMARK 620 4  MN U6042  MN   130.9  73.9 106.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN U6042  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS U 105   NE2                                                    
REMARK 620 2 ASP U 265   OD1  81.4                                              
REMARK 620 3 ASP U 342   OD1  95.0 138.6                                        
REMARK 620 4 ASP U 342   OD2  91.3  82.0  56.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN V6043  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS V 441   NE2                                                    
REMARK 620 2 ASP V 265   OD2  71.3                                              
REMARK 620 3 GLU V 296   OE1  71.9  77.3                                        
REMARK 620 4 GLU V 296   OE2  67.7 123.4  54.0                                  
REMARK 620 5  MN V6044  MN   146.2  81.7  82.8 114.5                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN V6044  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP V 342   OD1                                                    
REMARK 620 2 ASP V 342   OD2  55.6                                              
REMARK 620 3 HIS V 105   NE2  92.1  90.3                                        
REMARK 620 4 ASP V 265   OD1 137.9  82.7  81.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN W6045  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU W 296   OE2                                                    
REMARK 620 2 ASP W 265   OD2 120.6                                              
REMARK 620 3 GLU W 296   OE1  51.1  74.5                                        
REMARK 620 4  MN W6046  MN   110.0  76.5  79.2                                  
REMARK 620 5 HIS W 441   NE2  67.5  75.0  71.8 143.6                            
REMARK 620 6 HOH W6077   O    94.2 144.8 133.0  87.0 129.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN W6046  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH W6247   O                                                      
REMARK 620 2 ASP W 265   OD1 131.7                                              
REMARK 620 3 HIS W 105   NE2 146.2  75.2                                        
REMARK 620 4 ASP W 342   OD1  61.3 141.5  84.9                                  
REMARK 620 5 ASP W 342   OD2  76.1  88.4  86.2  57.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN X6047  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU X 296   OE2                                                    
REMARK 620 2 HIS X 441   NE2  67.3                                              
REMARK 620 3 ASP X 265   OD2 121.5  75.4                                        
REMARK 620 4 GLU X 296   OE1  50.7  73.2  76.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MN X6048  MN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS X 105   NE2                                                    
REMARK 620 2 ASP X 265   OD1  85.9                                              
REMARK 620 3 ASP X 342   OD2  99.2  90.1                                        
REMARK 620 4 ASP X 342   OD1  98.7 147.6  57.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN A 6001                 
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN A 6002                 
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN B 6003                 
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN B 6004                 
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN C 6005                 
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN C 6006                 
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN D 6007                 
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN D 6008                 
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN E 6009                 
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN E 6010                 
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN F 6011                 
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN F 6012                 
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN G 6013                 
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN G 6014                 
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN H 6015                 
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN H 6016                 
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN I 6017                 
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN I 6018                 
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN J 6019                 
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN J 6020                 
REMARK 800 SITE_IDENTIFIER: CC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN K 6021                 
REMARK 800 SITE_IDENTIFIER: CC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN K 6022                 
REMARK 800 SITE_IDENTIFIER: CC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN L 6023                 
REMARK 800 SITE_IDENTIFIER: CC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN L 6024                 
REMARK 800 SITE_IDENTIFIER: CC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN M 6025                 
REMARK 800 SITE_IDENTIFIER: CC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN M 6026                 
REMARK 800 SITE_IDENTIFIER: CC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN N 6027                 
REMARK 800 SITE_IDENTIFIER: DC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN N 6028                 
REMARK 800 SITE_IDENTIFIER: DC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN O 6029                 
REMARK 800 SITE_IDENTIFIER: DC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN O 6030                 
REMARK 800 SITE_IDENTIFIER: DC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN P 6031                 
REMARK 800 SITE_IDENTIFIER: DC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN P 6032                 
REMARK 800 SITE_IDENTIFIER: DC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN Q 6033                 
REMARK 800 SITE_IDENTIFIER: DC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN Q 6034                 
REMARK 800 SITE_IDENTIFIER: DC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN R 6035                 
REMARK 800 SITE_IDENTIFIER: DC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN R 6036                 
REMARK 800 SITE_IDENTIFIER: EC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN S 6037                 
REMARK 800 SITE_IDENTIFIER: EC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN S 6038                 
REMARK 800 SITE_IDENTIFIER: EC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN T 6039                 
REMARK 800 SITE_IDENTIFIER: EC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN T 6040                 
REMARK 800 SITE_IDENTIFIER: EC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN U 6041                 
REMARK 800 SITE_IDENTIFIER: EC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN U 6042                 
REMARK 800 SITE_IDENTIFIER: EC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN V 6043                 
REMARK 800 SITE_IDENTIFIER: EC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN V 6044                 
REMARK 800 SITE_IDENTIFIER: EC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN W 6045                 
REMARK 800 SITE_IDENTIFIER: FC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN W 6046                 
REMARK 800 SITE_IDENTIFIER: FC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN X 6047                 
REMARK 800 SITE_IDENTIFIER: FC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MN X 6048                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: NYSGXRC-T1817   RELATED DB: TARGETDB                     
DBREF  2GLJ A    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ B    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ C    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ D    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ E    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ F    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ G    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ H    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ I    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ J    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ K    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ L    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ M    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ N    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ O    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ P    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ Q    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ R    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ S    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ T    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ U    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ V    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ W    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
DBREF  2GLJ X    5   465  UNP    Q97K30   APEA_CLOAB       5    465             
SEQADV 2GLJ MSE A  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE B  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE C  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE D  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE E  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE F  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE G  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE H  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE I  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE J  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE K  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE L  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE M  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE N  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE O  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE P  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE Q  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE R  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE S  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE T  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE U  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE V  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE W  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQADV 2GLJ MSE X  440  UNP  Q97K30    MET   440 MODIFIED RESIDUE               
SEQRES   1 A  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 A  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 A  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 A  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 A  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 A  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 A  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 A  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 A  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 A  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 A  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 A  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 A  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 A  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 A  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 A  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 A  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 A  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 A  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 A  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 A  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 A  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 A  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 A  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 A  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 A  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 A  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 A  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 A  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 A  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 A  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 A  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 A  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 A  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 A  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 A  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 B  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 B  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 B  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 B  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 B  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 B  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 B  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 B  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 B  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 B  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 B  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 B  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 B  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 B  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 B  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 B  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 B  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 B  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 B  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 B  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 B  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 B  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 B  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 B  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 B  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 B  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 B  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 B  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 B  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 B  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 B  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 B  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 B  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 B  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 B  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 B  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 C  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 C  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 C  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 C  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 C  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 C  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 C  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 C  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 C  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 C  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 C  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 C  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 C  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 C  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 C  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 C  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 C  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 C  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 C  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 C  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 C  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 C  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 C  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 C  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 C  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 C  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 C  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 C  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 C  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 C  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 C  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 C  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 C  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 C  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 C  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 C  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 D  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 D  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 D  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 D  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 D  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 D  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 D  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 D  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 D  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 D  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 D  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 D  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 D  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 D  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 D  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 D  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 D  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 D  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 D  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 D  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 D  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 D  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 D  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 D  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 D  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 D  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 D  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 D  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 D  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 D  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 D  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 D  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 D  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 D  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 D  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 D  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 E  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 E  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 E  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 E  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 E  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 E  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 E  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 E  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 E  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 E  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 E  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 E  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 E  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 E  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 E  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 E  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 E  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 E  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 E  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 E  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 E  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 E  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 E  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 E  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 E  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 E  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 E  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 E  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 E  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 E  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 E  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 E  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 E  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 E  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 E  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 E  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 F  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 F  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 F  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 F  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 F  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 F  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 F  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 F  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 F  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 F  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 F  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 F  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 F  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 F  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 F  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 F  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 F  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 F  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 F  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 F  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 F  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 F  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 F  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 F  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 F  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 F  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 F  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 F  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 F  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 F  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 F  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 F  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 F  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 F  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 F  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 F  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 G  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 G  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 G  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 G  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 G  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 G  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 G  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 G  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 G  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 G  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 G  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 G  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 G  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 G  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 G  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 G  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 G  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 G  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 G  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 G  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 G  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 G  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 G  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 G  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 G  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 G  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 G  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 G  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 G  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 G  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 G  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 G  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 G  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 G  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 G  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 G  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 H  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 H  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 H  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 H  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 H  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 H  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 H  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 H  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 H  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 H  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 H  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 H  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 H  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 H  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 H  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 H  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 H  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 H  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 H  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 H  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 H  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 H  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 H  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 H  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 H  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 H  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 H  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 H  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 H  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 H  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 H  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 H  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 H  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 H  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 H  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 H  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 I  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 I  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 I  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 I  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 I  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 I  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 I  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 I  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 I  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 I  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 I  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 I  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 I  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 I  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 I  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 I  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 I  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 I  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 I  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 I  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 I  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 I  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 I  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 I  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 I  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 I  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 I  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 I  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 I  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 I  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 I  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 I  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 I  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 I  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 I  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 I  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 J  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 J  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 J  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 J  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 J  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 J  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 J  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 J  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 J  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 J  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 J  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 J  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 J  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 J  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 J  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 J  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 J  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 J  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 J  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 J  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 J  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 J  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 J  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 J  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 J  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 J  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 J  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 J  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 J  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 J  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 J  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 J  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 J  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 J  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 J  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 J  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 K  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 K  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 K  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 K  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 K  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 K  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 K  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 K  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 K  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 K  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 K  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 K  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 K  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 K  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 K  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 K  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 K  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 K  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 K  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 K  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 K  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 K  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 K  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 K  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 K  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 K  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 K  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 K  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 K  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 K  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 K  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 K  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 K  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 K  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 K  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 K  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 L  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 L  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 L  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 L  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 L  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 L  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 L  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 L  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 L  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 L  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 L  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 L  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 L  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 L  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 L  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 L  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 L  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 L  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 L  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 L  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 L  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 L  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 L  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 L  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 L  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 L  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 L  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 L  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 L  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 L  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 L  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 L  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 L  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 L  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 L  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 L  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 M  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 M  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 M  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 M  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 M  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 M  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 M  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 M  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 M  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 M  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 M  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 M  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 M  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 M  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 M  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 M  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 M  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 M  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 M  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 M  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 M  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 M  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 M  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 M  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 M  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 M  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 M  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 M  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 M  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 M  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 M  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 M  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 M  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 M  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 M  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 M  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 N  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 N  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 N  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 N  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 N  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 N  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 N  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 N  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 N  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 N  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 N  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 N  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 N  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 N  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 N  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 N  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 N  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 N  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 N  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 N  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 N  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 N  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 N  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 N  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 N  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 N  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 N  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 N  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 N  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 N  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 N  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 N  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 N  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 N  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 N  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 N  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 O  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 O  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 O  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 O  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 O  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 O  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 O  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 O  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 O  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 O  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 O  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 O  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 O  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 O  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 O  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 O  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 O  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 O  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 O  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 O  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 O  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 O  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 O  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 O  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 O  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 O  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 O  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 O  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 O  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 O  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 O  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 O  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 O  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 O  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 O  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 O  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 P  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 P  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 P  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 P  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 P  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 P  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 P  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 P  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 P  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 P  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 P  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 P  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 P  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 P  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 P  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 P  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 P  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 P  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 P  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 P  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 P  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 P  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 P  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 P  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 P  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 P  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 P  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 P  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 P  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 P  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 P  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 P  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 P  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 P  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 P  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 P  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 Q  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 Q  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 Q  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 Q  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 Q  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 Q  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 Q  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 Q  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 Q  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 Q  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 Q  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 Q  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 Q  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 Q  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 Q  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 Q  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 Q  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 Q  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 Q  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 Q  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 Q  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 Q  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 Q  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 Q  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 Q  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 Q  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 Q  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 Q  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 Q  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 Q  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 Q  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 Q  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 Q  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 Q  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 Q  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 Q  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 R  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 R  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 R  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 R  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 R  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 R  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 R  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 R  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 R  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 R  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 R  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 R  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 R  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 R  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 R  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 R  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 R  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 R  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 R  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 R  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 R  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 R  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 R  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 R  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 R  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 R  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 R  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 R  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 R  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 R  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 R  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 R  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 R  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 R  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 R  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 R  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 S  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 S  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 S  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 S  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 S  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 S  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 S  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 S  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 S  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 S  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 S  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 S  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 S  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 S  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 S  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 S  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 S  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 S  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 S  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 S  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 S  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 S  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 S  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 S  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 S  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 S  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 S  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 S  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 S  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 S  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 S  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 S  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 S  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 S  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 S  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 S  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 T  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 T  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 T  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 T  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 T  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 T  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 T  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 T  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 T  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 T  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 T  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 T  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 T  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 T  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 T  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 T  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 T  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 T  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 T  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 T  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 T  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 T  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 T  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 T  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 T  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 T  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 T  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 T  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 T  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 T  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 T  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 T  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 T  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 T  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 T  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 T  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 U  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 U  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 U  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 U  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 U  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 U  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 U  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 U  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 U  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 U  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 U  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 U  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 U  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 U  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 U  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 U  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 U  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 U  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 U  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 U  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 U  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 U  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 U  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 U  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 U  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 U  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 U  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 U  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 U  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 U  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 U  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 U  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 U  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 U  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 U  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 U  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 V  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 V  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 V  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 V  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 V  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 V  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 V  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 V  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 V  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 V  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 V  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 V  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 V  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 V  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 V  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 V  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 V  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 V  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 V  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 V  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 V  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 V  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 V  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 V  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 V  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 V  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 V  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 V  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 V  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 V  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 V  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 V  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 V  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 V  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 V  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 V  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 W  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 W  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 W  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 W  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 W  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 W  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 W  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 W  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 W  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 W  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 W  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 W  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 W  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 W  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 W  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 W  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 W  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 W  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 W  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 W  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 W  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 W  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 W  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 W  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 W  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 W  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 W  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 W  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 W  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 W  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 W  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 W  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 W  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 W  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 W  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 W  461  SER ALA PHE LEU ASN ASN                                      
SEQRES   1 X  461  LEU LEU LYS GLU TYR LYS ASN ALA TRP ASP LYS TYR ASP          
SEQRES   2 X  461  ASP LYS GLN LEU LYS GLU VAL PHE ALA LEU GLY ASP ARG          
SEQRES   3 X  461  PHE LYS ASN PHE ILE SER ASN CYS LYS THR GLU ARG GLU          
SEQRES   4 X  461  CYS VAL THR GLU LEU ILE LYS THR ALA GLU LYS SER GLY          
SEQRES   5 X  461  TYR ARG ASN ILE GLU ASP ILE LEU ALA LYS GLY GLU THR          
SEQRES   6 X  461  LEU LYS GLU GLY ASP LYS VAL TYR ALA ASN ASN ARG GLY          
SEQRES   7 X  461  LYS GLY LEU ILE MET PHE LEU ILE GLY LYS GLU PRO LEU          
SEQRES   8 X  461  TYR THR GLY PHE LYS ILE LEU GLY ALA HIS ILE ASP SER          
SEQRES   9 X  461  PRO ARG LEU ASP LEU LYS GLN ASN PRO LEU TYR GLU ASP          
SEQRES  10 X  461  THR ASP LEU ALA MET LEU GLU THR HIS TYR TYR GLY GLY          
SEQRES  11 X  461  ILE LYS LYS TYR GLN TRP VAL THR LEU PRO LEU ALA ILE          
SEQRES  12 X  461  HIS GLY VAL ILE VAL LYS LYS ASP GLY THR ILE VAL ASN          
SEQRES  13 X  461  VAL CYS VAL GLY GLU ASP ASP ASN ASP PRO VAL PHE GLY          
SEQRES  14 X  461  VAL SER ASP ILE LEU VAL HIS LEU ALA SER GLU GLN LEU          
SEQRES  15 X  461  GLU LYS LYS ALA SER LYS VAL ILE GLU GLY GLU ASP LEU          
SEQRES  16 X  461  ASN ILE LEU ILE GLY SER ILE PRO LEU LYS ASP GLY GLU          
SEQRES  17 X  461  GLU LYS GLN LYS VAL LYS HIS ASN ILE MET LYS ILE LEU          
SEQRES  18 X  461  ASN GLU LYS TYR ASP ILE SER GLU GLU ASP PHE VAL SER          
SEQRES  19 X  461  ALA GLU LEU GLU ILE VAL PRO ALA GLY LYS ALA ARG ASP          
SEQRES  20 X  461  TYR GLY PHE ASP ARG SER MET VAL MET GLY TYR GLY GLN          
SEQRES  21 X  461  ASP ASP ARG ILE CYS ALA TYR THR SER PHE GLU ALA MET          
SEQRES  22 X  461  LEU GLU MET LYS ASN ALA LYS LYS THR CYS ILE THR ILE          
SEQRES  23 X  461  LEU VAL ASP LYS GLU GLU VAL GLY SER ILE GLY ALA THR          
SEQRES  24 X  461  GLY MET GLN SER LYS PHE PHE GLU ASN THR VAL ALA ASP          
SEQRES  25 X  461  ILE MET SER LEU CYS GLY ASP TYR ASP GLU LEU LYS LEU          
SEQRES  26 X  461  ARG LYS ALA LEU TYR ASN SER GLU MET LEU SER SER ASP          
SEQRES  27 X  461  VAL SER ALA ALA PHE ASP PRO ASN TYR PRO ASN VAL MET          
SEQRES  28 X  461  GLU LYS ARG ASN SER ALA TYR LEU GLY LYS GLY ILE VAL          
SEQRES  29 X  461  PHE ASN LYS TYR THR GLY SER ARG GLY LYS SER GLY CYS          
SEQRES  30 X  461  ASN ASP ALA ASN PRO GLU TYR ILE ALA GLU LEU ARG ARG          
SEQRES  31 X  461  ILE LEU SER LYS GLU SER VAL ASN TRP GLN THR ALA GLU          
SEQRES  32 X  461  LEU GLY LYS VAL ASP GLN GLY GLY GLY GLY THR ILE ALA          
SEQRES  33 X  461  TYR ILE LEU ALA GLU TYR GLY MET GLN VAL ILE ASP CYS          
SEQRES  34 X  461  GLY VAL ALA LEU LEU ASN MSE HIS ALA PRO TRP GLU ILE          
SEQRES  35 X  461  SER SER LYS ALA ASP ILE TYR GLU THR LYS ASN GLY TYR          
SEQRES  36 X  461  SER ALA PHE LEU ASN ASN                                      
MODRES 2GLJ MSE A  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE B  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE C  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE D  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE E  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE F  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE G  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE H  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE I  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE J  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE K  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE L  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE M  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE N  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE O  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE P  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE Q  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE R  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE S  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE T  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE U  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE V  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE W  440  MET  SELENOMETHIONINE                                   
MODRES 2GLJ MSE X  440  MET  SELENOMETHIONINE                                   
HET    MSE  A 440       8                                                       
HET    MSE  B 440       8                                                       
HET    MSE  C 440       8                                                       
HET    MSE  D 440       8                                                       
HET    MSE  E 440       8                                                       
HET    MSE  F 440       8                                                       
HET    MSE  G 440       8                                                       
HET    MSE  H 440       8                                                       
HET    MSE  I 440       8                                                       
HET    MSE  J 440       8                                                       
HET    MSE  K 440       8                                                       
HET    MSE  L 440       8                                                       
HET    MSE  M 440       8                                                       
HET    MSE  N 440       8                                                       
HET    MSE  O 440       8                                                       
HET    MSE  P 440       8                                                       
HET    MSE  Q 440       8                                                       
HET    MSE  R 440       8                                                       
HET    MSE  S 440       8                                                       
HET    MSE  T 440       8                                                       
HET    MSE  U 440       8                                                       
HET    MSE  V 440       8                                                       
HET    MSE  W 440       8                                                       
HET    MSE  X 440       8                                                       
HET     MN  A6001       1                                                       
HET     MN  A6002       1                                                       
HET     MN  B6003       1                                                       
HET     MN  B6004       1                                                       
HET     MN  C6005       1                                                       
HET     MN  C6006       1                                                       
HET     MN  D6007       1                                                       
HET     MN  D6008       1                                                       
HET     MN  E6009       1                                                       
HET     MN  E6010       1                                                       
HET     MN  F6011       1                                                       
HET     MN  F6012       1                                                       
HET     MN  G6013       1                                                       
HET     MN  G6014       1                                                       
HET     MN  H6015       1                                                       
HET     MN  H6016       1                                                       
HET     MN  I6017       1                                                       
HET     MN  I6018       1                                                       
HET     MN  J6019       1                                                       
HET     MN  J6020       1                                                       
HET     MN  K6021       1                                                       
HET     MN  K6022       1                                                       
HET     MN  L6023       1                                                       
HET     MN  L6024       1                                                       
HET     MN  M6025       1                                                       
HET     MN  M6026       1                                                       
HET     MN  N6027       1                                                       
HET     MN  N6028       1                                                       
HET     MN  O6029       1                                                       
HET     MN  O6030       1                                                       
HET     MN  P6031       1                                                       
HET     MN  P6032       1                                                       
HET     MN  Q6033       1                                                       
HET     MN  Q6034       1                                                       
HET     MN  R6035       1                                                       
HET     MN  R6036       1                                                       
HET     MN  S6037       1                                                       
HET     MN  S6038       1                                                       
HET     MN  T6039       1                                                       
HET     MN  T6040       1                                                       
HET     MN  U6041       1                                                       
HET     MN  U6042       1                                                       
HET     MN  V6043       1                                                       
HET     MN  V6044       1                                                       
HET     MN  W6045       1                                                       
HET     MN  W6046       1                                                       
HET     MN  X6047       1                                                       
HET     MN  X6048       1                                                       
HETNAM     MSE SELENOMETHIONINE                                                 
HETNAM      MN MANGANESE (II) ION                                               
FORMUL   1  MSE    24(C5 H11 N O2 SE)                                           
FORMUL  25   MN    48(MN 2+)                                                    
FORMUL  73  HOH   *5233(H2 O)                                                   
HELIX    1   1 LYS A   19  LEU A   27  1                                   9    
HELIX    2   2 GLY A   28  ASN A   37  1                                  10    
HELIX    3   3 CYS A   44  ALA A   52  1                                   9    
HELIX    4   4 PRO A   94  GLY A   98  5                                   5    
HELIX    5   5 LEU A  178  GLN A  185  5                                   8    
HELIX    6   6 GLN A  215  LYS A  228  1                                  14    
HELIX    7   7 ASP A  235  ALA A  239  5                                   5    
HELIX    8   8 GLY A  263  GLU A  279  1                                  17    
HELIX    9   9 LYS A  294  GLY A  298  5                                   5    
HELIX   10  10 PHE A  309  MET A  318  1                                  10    
HELIX   11  11 ARG A  330  ASN A  335  1                                   6    
HELIX   12  12 ASN A  385  GLU A  399  1                                  15    
HELIX   13  13 ILE A  419  GLU A  425  1                                   7    
HELIX   14  14 LYS A  449  ALA A  461  1                                  13    
HELIX   15  15 ASN B   11  TYR B   16  1                                   6    
HELIX   16  16 LYS B   19  LEU B   27  1                                   9    
HELIX   17  17 GLY B   28  ASN B   37  1                                  10    
HELIX   18  18 CYS B   44  ALA B   52  1                                   9    
HELIX   19  19 PRO B   94  GLY B   98  5                                   5    
HELIX   20  20 LEU B  178  GLN B  185  5                                   8    
HELIX   21  21 GLN B  215  LYS B  228  1                                  14    
HELIX   22  22 ASP B  235  ALA B  239  5                                   5    
HELIX   23  23 GLY B  263  GLU B  279  1                                  17    
HELIX   24  24 LYS B  294  GLY B  298  5                                   5    
HELIX   25  25 PHE B  309  MET B  318  1                                  10    
HELIX   26  26 ARG B  330  ASN B  335  1                                   6    
HELIX   27  27 ASN B  385  GLU B  399  1                                  15    
HELIX   28  28 ILE B  419  GLU B  425  1                                   7    
HELIX   29  29 LYS B  449  ALA B  461  1                                  13    
HELIX   30  30 ASN C   11  TYR C   16  1                                   6    
HELIX   31  31 LYS C   19  LEU C   27  1                                   9    
HELIX   32  32 GLY C   28  ASN C   37  1                                  10    
HELIX   33  33 CYS C   44  ALA C   52  1                                   9    
HELIX   34  34 PRO C   94  GLY C   98  5                                   5    
HELIX   35  35 LEU C  178  GLN C  185  5                                   8    
HELIX   36  36 GLN C  215  LYS C  228  1                                  14    
HELIX   37  37 ASP C  235  ALA C  239  5                                   5    
HELIX   38  38 GLY C  263  GLU C  279  1                                  17    
HELIX   39  39 LYS C  294  GLY C  298  5                                   5    
HELIX   40  40 PHE C  309  MET C  318  1                                  10    
HELIX   41  41 ARG C  330  ASN C  335  1                                   6    
HELIX   42  42 ASN C  385  GLU C  399  1                                  15    
HELIX   43  43 ILE C  419  GLU C  425  1                                   7    
HELIX   44  44 LYS C  449  ALA C  461  1                                  13    
HELIX   45  45 ASN D   11  TYR D   16  1                                   6    
HELIX   46  46 LYS D   19  LEU D   27  1                                   9    
HELIX   47  47 GLY D   28  ASN D   37  1                                  10    
HELIX   48  48 CYS D   44  ALA D   52  1                                   9    
HELIX   49  49 PRO D   94  GLY D   98  5                                   5    
HELIX   50  50 LEU D  178  GLN D  185  5                                   8    
HELIX   51  51 GLN D  215  LYS D  228  1                                  14    
HELIX   52  52 ASP D  235  ALA D  239  5                                   5    
HELIX   53  53 GLY D  263  GLU D  279  1                                  17    
HELIX   54  54 LYS D  294  GLY D  298  5                                   5    
HELIX   55  55 PHE D  309  MET D  318  1                                  10    
HELIX   56  56 ARG D  330  ASN D  335  1                                   6    
HELIX   57  57 ASN D  385  GLU D  399  1                                  15    
HELIX   58  58 ILE D  419  GLU D  425  1                                   7    
HELIX   59  59 LYS D  449  ALA D  461  1                                  13    
HELIX   60  60 LYS E   19  LEU E   27  1                                   9    
HELIX   61  61 GLY E   28  ASN E   37  1                                  10    
HELIX   62  62 CYS E   44  ALA E   52  1                                   9    
HELIX   63  63 PRO E   94  GLY E   98  5                                   5    
HELIX   64  64 LEU E  178  GLN E  185  5                                   8    
HELIX   65  65 GLN E  215  LYS E  228  1                                  14    
HELIX   66  66 ASP E  235  ALA E  239  5                                   5    
HELIX   67  67 GLY E  263  GLU E  279  1                                  17    
HELIX   68  68 LYS E  294  GLY E  298  5                                   5    
HELIX   69  69 PHE E  309  MET E  318  1                                  10    
HELIX   70  70 ARG E  330  ASN E  335  1                                   6    
HELIX   71  71 ASN E  385  GLU E  399  1                                  15    
HELIX   72  72 ILE E  419  GLU E  425  1                                   7    
HELIX   73  73 LYS E  449  ALA E  461  1                                  13    
HELIX   74  74 ASN F   11  TYR F   16  1                                   6    
HELIX   75  75 LYS F   19  LEU F   27  1                                   9    
HELIX   76  76 GLY F   28  ASN F   37  1                                  10    
HELIX   77  77 CYS F   44  ALA F   52  1                                   9    
HELIX   78  78 PRO F   94  GLY F   98  5                                   5    
HELIX   79  79 LEU F  178  GLN F  185  5                                   8    
HELIX   80  80 GLN F  215  LYS F  228  1                                  14    
HELIX   81  81 ASP F  235  ALA F  239  5                                   5    
HELIX   82  82 GLY F  263  GLU F  279  1                                  17    
HELIX   83  83 PHE F  309  MET F  318  1                                  10    
HELIX   84  84 ARG F  330  ASN F  335  1                                   6    
HELIX   85  85 ASN F  385  GLU F  399  1                                  15    
HELIX   86  86 ILE F  419  GLU F  425  1                                   7    
HELIX   87  87 LYS F  449  ALA F  461  1                                  13    
HELIX   88  88 LYS G   19  LEU G   27  1                                   9    
HELIX   89  89 GLY G   28  ASN G   37  1                                  10    
HELIX   90  90 CYS G   44  ALA G   52  1                                   9    
HELIX   91  91 PRO G   94  GLY G   98  5                                   5    
HELIX   92  92 LEU G  178  GLN G  185  5                                   8    
HELIX   93  93 GLN G  215  LYS G  228  1                                  14    
HELIX   94  94 ASP G  235  ALA G  239  5                                   5    
HELIX   95  95 GLY G  263  GLU G  279  1                                  17    
HELIX   96  96 LYS G  294  GLY G  298  5                                   5    
HELIX   97  97 PHE G  309  MET G  318  1                                  10    
HELIX   98  98 ARG G  330  ASN G  335  1                                   6    
HELIX   99  99 ASN G  385  GLU G  399  1                                  15    
HELIX  100 100 ILE G  419  GLU G  425  1                                   7    
HELIX  101 101 LYS G  449  ALA G  461  1                                  13    
HELIX  102 102 LYS H   19  LEU H   27  1                                   9    
HELIX  103 103 GLY H   28  ASN H   37  1                                  10    
HELIX  104 104 CYS H   44  ALA H   52  1                                   9    
HELIX  105 105 PRO H   94  GLY H   98  5                                   5    
HELIX  106 106 LEU H  178  GLN H  185  5                                   8    
HELIX  107 107 GLN H  215  LYS H  228  1                                  14    
HELIX  108 108 ASP H  235  ALA H  239  5                                   5    
HELIX  109 109 GLY H  263  GLU H  279  1                                  17    
HELIX  110 110 LYS H  294  GLY H  298  5                                   5    
HELIX  111 111 PHE H  309  MET H  318  1                                  10    
HELIX  112 112 ARG H  330  ASN H  335  1                                   6    
HELIX  113 113 ASN H  385  GLU H  399  1                                  15    
HELIX  114 114 ILE H  419  GLU H  425  1                                   7    
HELIX  115 115 LYS H  449  ALA H  461  1                                  13    
HELIX  116 116 LYS I   19  LEU I   27  1                                   9    
HELIX  117 117 GLY I   28  ASN I   37  1                                  10    
HELIX  118 118 CYS I   44  ALA I   52  1                                   9    
HELIX  119 119 PRO I   94  GLY I   98  5                                   5    
HELIX  120 120 LEU I  178  GLN I  185  5                                   8    
HELIX  121 121 GLN I  215  LYS I  228  1                                  14    
HELIX  122 122 ASP I  235  ALA I  239  5                                   5    
HELIX  123 123 GLY I  263  GLU I  279  1                                  17    
HELIX  124 124 LYS I  294  GLY I  298  5                                   5    
HELIX  125 125 PHE I  309  MET I  318  1                                  10    
HELIX  126 126 ARG I  330  ASN I  335  1                                   6    
HELIX  127 127 ASN I  385  GLU I  399  1                                  15    
HELIX  128 128 ILE I  419  GLU I  425  1                                   7    
HELIX  129 129 LYS I  449  ALA I  461  1                                  13    
HELIX  130 130 ASN J   11  TYR J   16  1                                   6    
HELIX  131 131 LYS J   19  LEU J   27  1                                   9    
HELIX  132 132 GLY J   28  ASN J   37  1                                  10    
HELIX  133 133 CYS J   44  ALA J   52  1                                   9    
HELIX  134 134 PRO J   94  GLY J   98  5                                   5    
HELIX  135 135 LEU J  178  GLN J  185  5                                   8    
HELIX  136 136 GLN J  215  LYS J  228  1                                  14    
HELIX  137 137 ASP J  235  ALA J  239  5                                   5    
HELIX  138 138 GLY J  263  GLU J  279  1                                  17    
HELIX  139 139 LYS J  294  GLY J  298  5                                   5    
HELIX  140 140 PHE J  309  MET J  318  1                                  10    
HELIX  141 141 ARG J  330  ASN J  335  1                                   6    
HELIX  142 142 ASN J  385  GLU J  399  1                                  15    
HELIX  143 143 ILE J  419  GLU J  425  1                                   7    
HELIX  144 144 LYS J  449  ALA J  461  1                                  13    
HELIX  145 145 LYS K   19  LEU K   27  1                                   9    
HELIX  146 146 GLY K   28  ASN K   37  1                                  10    
HELIX  147 147 CYS K   44  ALA K   52  1                                   9    
HELIX  148 148 PRO K   94  GLY K   98  5                                   5    
HELIX  149 149 LEU K  178  GLN K  185  5                                   8    
HELIX  150 150 GLN K  215  LYS K  228  1                                  14    
HELIX  151 151 ASP K  235  ALA K  239  5                                   5    
HELIX  152 152 GLY K  263  GLU K  279  1                                  17    
HELIX  153 153 LYS K  294  GLY K  298  5                                   5    
HELIX  154 154 PHE K  309  MET K  318  1                                  10    
HELIX  155 155 ARG K  330  ASN K  335  1                                   6    
HELIX  156 156 ASN K  385  GLU K  399  1                                  15    
HELIX  157 157 ILE K  419  GLU K  425  1                                   7    
HELIX  158 158 LYS K  449  ALA K  461  1                                  13    
HELIX  159 159 LYS L   19  LEU L   27  1                                   9    
HELIX  160 160 GLY L   28  ASN L   37  1                                  10    
HELIX  161 161 CYS L   44  ALA L   52  1                                   9    
HELIX  162 162 PRO L   94  GLY L   98  5                                   5    
HELIX  163 163 LEU L  178  GLN L  185  5                                   8    
HELIX  164 164 GLN L  215  LYS L  228  1                                  14    
HELIX  165 165 ASP L  235  ALA L  239  5                                   5    
HELIX  166 166 GLY L  263  GLU L  279  1                                  17    
HELIX  167 167 LYS L  294  GLY L  298  5                                   5    
HELIX  168 168 PHE L  309  MET L  318  1                                  10    
HELIX  169 169 ARG L  330  ASN L  335  1                                   6    
HELIX  170 170 ASN L  385  GLU L  399  1                                  15    
HELIX  171 171 ILE L  419  GLU L  425  1                                   7    
HELIX  172 172 LYS L  449  ALA L  461  1                                  13    
HELIX  173 173 ASN M   11  TYR M   16  1                                   6    
HELIX  174 174 LYS M   19  LEU M   27  1                                   9    
HELIX  175 175 GLY M   28  ASN M   37  1                                  10    
HELIX  176 176 CYS M   44  ALA M   52  1                                   9    
HELIX  177 177 PRO M   94  GLY M   98  5                                   5    
HELIX  178 178 LEU M  178  GLN M  185  5                                   8    
HELIX  179 179 GLN M  215  LYS M  228  1                                  14    
HELIX  180 180 ASP M  235  ALA M  239  5                                   5    
HELIX  181 181 GLY M  263  GLU M  279  1                                  17    
HELIX  182 182 LYS M  294  GLY M  298  5                                   5    
HELIX  183 183 PHE M  309  MET M  318  1                                  10    
HELIX  184 184 ARG M  330  ASN M  335  1                                   6    
HELIX  185 185 ASN M  385  GLU M  399  1                                  15    
HELIX  186 186 ILE M  419  GLU M  425  1                                   7    
HELIX  187 187 LYS M  449  ALA M  461  1                                  13    
HELIX  188 188 LYS N   19  LEU N   27  1                                   9    
HELIX  189 189 GLY N   28  ASN N   37  1                                  10    
HELIX  190 190 CYS N   44  ALA N   52  1                                   9    
HELIX  191 191 PRO N   94  GLY N   98  5                                   5    
HELIX  192 192 LEU N  178  GLN N  185  5                                   8    
HELIX  193 193 GLN N  215  LYS N  228  1                                  14    
HELIX  194 194 ASP N  235  ALA N  239  5                                   5    
HELIX  195 195 GLY N  263  GLU N  279  1                                  17    
HELIX  196 196 LYS N  294  GLY N  298  5                                   5    
HELIX  197 197 PHE N  309  MET N  318  1                                  10    
HELIX  198 198 ARG N  330  ASN N  335  1                                   6    
HELIX  199 199 ASN N  385  GLU N  399  1                                  15    
HELIX  200 200 ILE N  419  GLU N  425  1                                   7    
HELIX  201 201 LYS N  449  ALA N  461  1                                  13    
HELIX  202 202 LYS O   19  LEU O   27  1                                   9    
HELIX  203 203 GLY O   28  ASN O   37  1                                  10    
HELIX  204 204 CYS O   44  ALA O   52  1                                   9    
HELIX  205 205 PRO O   94  GLY O   98  5                                   5    
HELIX  206 206 LEU O  178  GLN O  185  5                                   8    
HELIX  207 207 GLN O  215  LYS O  228  1                                  14    
HELIX  208 208 ASP O  235  ALA O  239  5                                   5    
HELIX  209 209 GLY O  263  GLU O  279  1                                  17    
HELIX  210 210 LYS O  294  GLY O  298  5                                   5    
HELIX  211 211 PHE O  309  MET O  318  1                                  10    
HELIX  212 212 ARG O  330  ASN O  335  1                                   6    
HELIX  213 213 ASN O  385  GLU O  399  1                                  15    
HELIX  214 214 ILE O  419  GLU O  425  1                                   7    
HELIX  215 215 LYS O  449  ALA O  461  1                                  13    
HELIX  216 216 ASN P   11  TYR P   16  1                                   6    
HELIX  217 217 LYS P   19  LEU P   27  1                                   9    
HELIX  218 218 GLY P   28  ASN P   37  1                                  10    
HELIX  219 219 CYS P   44  ALA P   52  1                                   9    
HELIX  220 220 PRO P   94  GLY P   98  5                                   5    
HELIX  221 221 LEU P  178  GLN P  185  5                                   8    
HELIX  222 222 GLN P  215  LYS P  228  1                                  14    
HELIX  223 223 ASP P  235  ALA P  239  5                                   5    
HELIX  224 224 GLY P  263  GLU P  279  1                                  17    
HELIX  225 225 LYS P  294  GLY P  298  5                                   5    
HELIX  226 226 PHE P  309  MET P  318  1                                  10    
HELIX  227 227 ARG P  330  ASN P  335  1                                   6    
HELIX  228 228 ASN P  385  GLU P  399  1                                  15    
HELIX  229 229 ILE P  419  GLU P  425  1                                   7    
HELIX  230 230 LYS P  449  ALA P  461  1                                  13    
HELIX  231 231 LYS Q   19  LEU Q   27  1                                   9    
HELIX  232 232 GLY Q   28  ASN Q   37  1                                  10    
HELIX  233 233 CYS Q   44  ALA Q   52  1                                   9    
HELIX  234 234 PRO Q   94  GLY Q   98  5                                   5    
HELIX  235 235 LEU Q  178  GLN Q  185  5                                   8    
HELIX  236 236 GLN Q  215  LYS Q  228  1                                  14    
HELIX  237 237 ASP Q  235  ALA Q  239  5                                   5    
HELIX  238 238 GLY Q  263  GLU Q  279  1                                  17    
HELIX  239 239 LYS Q  294  GLY Q  298  5                                   5    
HELIX  240 240 PHE Q  309  MET Q  318  1                                  10    
HELIX  241 241 ARG Q  330  ASN Q  335  1                                   6    
HELIX  242 242 ASN Q  385  GLU Q  399  1                                  15    
HELIX  243 243 ILE Q  419  GLU Q  425  1                                   7    
HELIX  244 244 LYS Q  449  ALA Q  461  1                                  13    
HELIX  245 245 LYS R   19  LEU R   27  1                                   9    
HELIX  246 246 GLY R   28  ASN R   37  1                                  10    
HELIX  247 247 CYS R   44  ALA R   52  1                                   9    
HELIX  248 248 PRO R   94  GLY R   98  5                                   5    
HELIX  249 249 LEU R  178  GLN R  185  5                                   8    
HELIX  250 250 GLN R  215  LYS R  228  1                                  14    
HELIX  251 251 ASP R  235  ALA R  239  5                                   5    
HELIX  252 252 GLY R  263  GLU R  279  1                                  17    
HELIX  253 253 LYS R  294  GLY R  298  5                                   5    
HELIX  254 254 PHE R  309  MET R  318  1                                  10    
HELIX  255 255 ARG R  330  ASN R  335  1                                   6    
HELIX  256 256 ASN R  385  GLU R  399  1                                  15    
HELIX  257 257 ILE R  419  GLU R  425  1                                   7    
HELIX  258 258 LYS R  449  ALA R  461  1                                  13    
HELIX  259 259 ASN S   11  TYR S   16  1                                   6    
HELIX  260 260 LYS S   19  LEU S   27  1                                   9    
HELIX  261 261 GLY S   28  ASN S   37  1                                  10    
HELIX  262 262 CYS S   44  ALA S   52  1                                   9    
HELIX  263 263 PRO S   94  GLY S   98  5                                   5    
HELIX  264 264 LEU S  178  GLN S  185  5                                   8    
HELIX  265 265 GLN S  215  LYS S  228  1                                  14    
HELIX  266 266 ASP S  235  ALA S  239  5                                   5    
HELIX  267 267 GLY S  263  GLU S  279  1                                  17    
HELIX  268 268 LYS S  294  GLY S  298  5                                   5    
HELIX  269 269 PHE S  309  MET S  318  1                                  10    
HELIX  270 270 ARG S  330  ASN S  335  1                                   6    
HELIX  271 271 ASN S  385  GLU S  399  1                                  15    
HELIX  272 272 ILE S  419  GLU S  425  1                                   7    
HELIX  273 273 LYS S  449  ALA S  461  1                                  13    
HELIX  274 274 LYS T   19  LEU T   27  1                                   9    
HELIX  275 275 GLY T   28  ASN T   37  1                                  10    
HELIX  276 276 CYS T   44  ALA T   52  1                                   9    
HELIX  277 277 PRO T   94  GLY T   98  5                                   5    
HELIX  278 278 LEU T  178  GLN T  185  5                                   8    
HELIX  279 279 GLN T  215  LYS T  228  1                                  14    
HELIX  280 280 ASP T  235  ALA T  239  5                                   5    
HELIX  281 281 GLY T  263  GLU T  279  1                                  17    
HELIX  282 282 LYS T  294  GLY T  298  5                                   5    
HELIX  283 283 PHE T  309  MET T  318  1                                  10    
HELIX  284 284 ARG T  330  ASN T  335  1                                   6    
HELIX  285 285 ASN T  385  GLU T  399  1                                  15    
HELIX  286 286 ILE T  419  GLU T  425  1                                   7    
HELIX  287 287 LYS T  449  ALA T  461  1                                  13    
HELIX  288 288 LYS U   19  LEU U   27  1                                   9    
HELIX  289 289 GLY U   28  ASN U   37  1                                  10    
HELIX  290 290 CYS U   44  ALA U   52  1                                   9    
HELIX  291 291 PRO U   94  GLY U   98  5                                   5    
HELIX  292 292 LEU U  178  GLN U  185  5                                   8    
HELIX  293 293 GLN U  215  LYS U  228  1                                  14    
HELIX  294 294 ASP U  235  ALA U  239  5                                   5    
HELIX  295 295 GLY U  263  GLU U  279  1                                  17    
HELIX  296 296 PHE U  309  MET U  318  1                                  10    
HELIX  297 297 ARG U  330  ASN U  335  1                                   6    
HELIX  298 298 ASN U  385  GLU U  399  1                                  15    
HELIX  299 299 ILE U  419  GLU U  425  1                                   7    
HELIX  300 300 LYS U  449  ALA U  461  1                                  13    
HELIX  301 301 LYS V   19  LEU V   27  1                                   9    
HELIX  302 302 GLY V   28  ASN V   37  1                                  10    
HELIX  303 303 CYS V   44  ALA V   52  1                                   9    
HELIX  304 304 PRO V   94  GLY V   98  5                                   5    
HELIX  305 305 LEU V  178  GLN V  185  5                                   8    
HELIX  306 306 GLN V  215  LYS V  228  1                                  14    
HELIX  307 307 ASP V  235  ALA V  239  5                                   5    
HELIX  308 308 GLY V  263  GLU V  279  1                                  17    
HELIX  309 309 LYS V  294  GLY V  298  5                                   5    
HELIX  310 310 PHE V  309  MET V  318  1                                  10    
HELIX  311 311 ARG V  330  ASN V  335  1                                   6    
HELIX  312 312 ASN V  385  GLU V  399  1                                  15    
HELIX  313 313 ILE V  419  GLU V  425  1                                   7    
HELIX  314 314 LYS V  449  ALA V  461  1                                  13    
HELIX  315 315 ASN W   11  TYR W   16  1                                   6    
HELIX  316 316 LYS W   19  LEU W   27  1                                   9    
HELIX  317 317 GLY W   28  ASN W   37  1                                  10    
HELIX  318 318 CYS W   44  ALA W   52  1                                   9    
HELIX  319 319 PRO W   94  GLY W   98  5                                   5    
HELIX  320 320 LEU W  178  GLN W  185  5                                   8    
HELIX  321 321 GLN W  215  LYS W  228  1                                  14    
HELIX  322 322 ASP W  235  ALA W  239  5                                   5    
HELIX  323 323 GLY W  263  GLU W  279  1                                  17    
HELIX  324 324 LYS W  294  GLY W  298  5                                   5    
HELIX  325 325 PHE W  309  MET W  318  1                                  10    
HELIX  326 326 ARG W  330  ASN W  335  1                                   6    
HELIX  327 327 ASN W  385  GLU W  399  1                                  15    
HELIX  328 328 ILE W  419  GLU W  425  1                                   7    
HELIX  329 329 LYS W  449  ALA W  461  1                                  13    
HELIX  330 330 ASN X   11  TYR X   16  1                                   6    
HELIX  331 331 LYS X   19  LEU X   27  1                                   9    
HELIX  332 332 GLY X   28  ASN X   37  1                                  10    
HELIX  333 333 CYS X   44  ALA X   52  1                                   9    
HELIX  334 334 PRO X   94  GLY X   98  5                                   5    
HELIX  335 335 LEU X  178  GLN X  185  5                                   8    
HELIX  336 336 GLN X  215  LYS X  228  1                                  14    
HELIX  337 337 ASP X  235  ALA X  239  5                                   5    
HELIX  338 338 GLY X  263  GLU X  279  1                                  17    
HELIX  339 339 LYS X  294  GLY X  298  5                                   5    
HELIX  340 340 PHE X  309  MET X  318  1                                  10    
HELIX  341 341 ARG X  330  ASN X  335  1                                   6    
HELIX  342 342 ASN X  385  GLU X  399  1                                  15    
HELIX  343 343 ILE X  419  GLU X  425  1                                   7    
HELIX  344 344 LYS X  449  ALA X  461  1                                  13    
SHEET    1   A 5 TYR A  77  ASN A  80  0                                        
SHEET    2   A 5 GLY A  84  MET A  87 -1  O  GLY A  84   N  ASN A  80           
SHEET    3   A 5 CYS A 287  VAL A 292 -1  O  THR A 289   N  MET A  87           
SHEET    4   A 5 LYS A 100  HIS A 105  1  N  LEU A 102   O  ILE A 290           
SHEET    5   A 5 GLU A 337  MET A 338  1  O  GLU A 337   N  ILE A 101           
SHEET    1   B 3 LEU A 118  GLU A 120  0                                        
SHEET    2   B 3 ALA A 125  LEU A 127 -1  O  MET A 126   N  TYR A 119           
SHEET    3   B 3 ASN A 200  LEU A 202 -1  O  LEU A 202   N  ALA A 125           
SHEET    1   C 2 LEU A 145  ILE A 147  0                                        
SHEET    2   C 2 ILE A 243  PRO A 245 -1  O  VAL A 244   N  ALA A 146           
SHEET    1   D 2 VAL A 150  VAL A 152  0                                        
SHEET    2   D 2 ILE A 158  ASN A 160 -1  O  VAL A 159   N  ILE A 151           
SHEET    1   E 5 ARG A 250  TYR A 252  0                                        
SHEET    2   E 5 MET A 258  GLY A 261 -1  O  MET A 258   N  TYR A 252           
SHEET    3   E 5 GLU A 445  SER A 448 -1  O  GLU A 445   N  GLY A 261           
SHEET    4   E 5 ALA A 436  LEU A 438 -1  N  LEU A 438   O  ILE A 446           
SHEET    5   E 5 SER A 344  ALA A 345  1  N  SER A 344   O  LEU A 437           
SHEET    1   F 2 ILE A 367  PHE A 369  0                                        
SHEET    2   F 2 TRP A 403  THR A 405  1  O  GLN A 404   N  ILE A 367           
SHEET    1   G 5 TYR B  77  ASN B  80  0                                        
SHEET    2   G 5 GLY B  84  LEU B  89 -1  O  GLY B  84   N  ASN B  80           
SHEET    3   G 5 CYS B 287  VAL B 292 -1  O  THR B 289   N  MET B  87           
SHEET    4   G 5 LYS B 100  HIS B 105  1  N  LEU B 102   O  ILE B 290           
SHEET    5   G 5 GLU B 337  MET B 338  1  O  GLU B 337   N  ILE B 101           
SHEET    1   H 3 LEU B 118  GLU B 120  0                                        
SHEET    2   H 3 ALA B 125  LEU B 127 -1  O  MET B 126   N  TYR B 119           
SHEET    3   H 3 ASN B 200  LEU B 202 -1  O  LEU B 202   N  ALA B 125           
SHEET    1   I 2 LEU B 145  ILE B 147  0                                        
SHEET    2   I 2 ILE B 243  PRO B 245 -1  O  VAL B 244   N  ALA B 146           
SHEET    1   J 2 VAL B 150  VAL B 152  0                                        
SHEET    2   J 2 ILE B 158  ASN B 160 -1  O  VAL B 159   N  ILE B 151           
SHEET    1   K 5 ARG B 250  TYR B 252  0                                        
SHEET    2   K 5 MET B 258  GLY B 261 -1  O  MET B 258   N  TYR B 252           
SHEET    3   K 5 GLU B 445  SER B 448 -1  O  GLU B 445   N  GLY B 261           
SHEET    4   K 5 ALA B 436  LEU B 438 -1  N  LEU B 438   O  ILE B 446           
SHEET    5   K 5 SER B 344  ALA B 345  1  N  SER B 344   O  LEU B 437           
SHEET    1   L 2 ILE B 367  PHE B 369  0                                        
SHEET    2   L 2 TRP B 403  THR B 405  1  O  GLN B 404   N  ILE B 367           
SHEET    1   M 5 TYR C  77  ASN C  80  0                                        
SHEET    2   M 5 GLY C  84  LEU C  89 -1  O  GLY C  84   N  ASN C  80           
SHEET    3   M 5 CYS C 287  VAL C 292 -1  O  THR C 289   N  MET C  87           
SHEET    4   M 5 LYS C 100  HIS C 105  1  N  LEU C 102   O  ILE C 290           
SHEET    5   M 5 GLU C 337  MET C 338  1  O  GLU C 337   N  ILE C 101           
SHEET    1   N 3 LEU C 118  GLU C 120  0                                        
SHEET    2   N 3 ALA C 125  LEU C 127 -1  O  MET C 126   N  TYR C 119           
SHEET    3   N 3 ASN C 200  LEU C 202 -1  O  LEU C 202   N  ALA C 125           
SHEET    1   O 2 LEU C 145  ILE C 147  0                                        
SHEET    2   O 2 ILE C 243  PRO C 245 -1  O  VAL C 244   N  ALA C 146           
SHEET    1   P 2 VAL C 150  VAL C 152  0                                        
SHEET    2   P 2 ILE C 158  ASN C 160 -1  O  VAL C 159   N  ILE C 151           
SHEET    1   Q 5 ARG C 250  TYR C 252  0                                        
SHEET    2   Q 5 MET C 258  GLY C 261 -1  O  MET C 258   N  TYR C 252           
SHEET    3   Q 5 GLU C 445  SER C 448 -1  O  GLU C 445   N  GLY C 261           
SHEET    4   Q 5 ALA C 436  LEU C 438 -1  N  LEU C 438   O  ILE C 446           
SHEET    5   Q 5 SER C 344  ALA C 345  1  N  SER C 344   O  LEU C 437           
SHEET    1   R 2 ILE C 367  PHE C 369  0                                        
SHEET    2   R 2 TRP C 403  THR C 405  1  O  GLN C 404   N  ILE C 367           
SHEET    1   S 5 TYR D  77  ASN D  80  0                                        
SHEET    2   S 5 GLY D  84  MET D  87 -1  O  GLY D  84   N  ASN D  80           
SHEET    3   S 5 CYS D 287  VAL D 292 -1  O  THR D 289   N  MET D  87           
SHEET    4   S 5 LYS D 100  HIS D 105  1  N  LEU D 102   O  ILE D 290           
SHEET    5   S 5 GLU D 337  MET D 338  1  O  GLU D 337   N  ILE D 101           
SHEET    1   T 3 LEU D 118  GLU D 120  0                                        
SHEET    2   T 3 ALA D 125  LEU D 127 -1  O  MET D 126   N  TYR D 119           
SHEET    3   T 3 ASN D 200  LEU D 202 -1  O  LEU D 202   N  ALA D 125           
SHEET    1   U 2 LEU D 145  ILE D 147  0                                        
SHEET    2   U 2 ILE D 243  PRO D 245 -1  O  VAL D 244   N  ALA D 146           
SHEET    1   V 2 VAL D 150  VAL D 152  0                                        
SHEET    2   V 2 ILE D 158  ASN D 160 -1  O  VAL D 159   N  ILE D 151           
SHEET    1   W 5 ARG D 250  TYR D 252  0                                        
SHEET    2   W 5 MET D 258  GLY D 261 -1  O  MET D 258   N  TYR D 252           
SHEET    3   W 5 GLU D 445  SER D 448 -1  O  GLU D 445   N  GLY D 261           
SHEET    4   W 5 ALA D 436  LEU D 438 -1  N  LEU D 438   O  ILE D 446           
SHEET    5   W 5 SER D 344  ALA D 345  1  N  SER D 344   O  LEU D 437           
SHEET    1   X 2 ILE D 367  PHE D 369  0                                        
SHEET    2   X 2 TRP D 403  THR D 405  1  O  GLN D 404   N  ILE D 367           
SHEET    1   Y 5 TYR E  77  ASN E  80  0                                        
SHEET    2   Y 5 GLY E  84  LEU E  89 -1  O  GLY E  84   N  ASN E  80           
SHEET    3   Y 5 CYS E 287  VAL E 292 -1  O  THR E 289   N  MET E  87           
SHEET    4   Y 5 LYS E 100  HIS E 105  1  N  LEU E 102   O  ILE E 290           
SHEET    5   Y 5 GLU E 337  SER E 340  1  O  GLU E 337   N  ILE E 101           
SHEET    1   Z 3 LEU E 118  GLU E 120  0                                        
SHEET    2   Z 3 ALA E 125  LEU E 127 -1  O  MET E 126   N  TYR E 119           
SHEET    3   Z 3 ASN E 200  LEU E 202 -1  O  LEU E 202   N  ALA E 125           
SHEET    1  AA 2 LEU E 145  ILE E 147  0                                        
SHEET    2  AA 2 ILE E 243  PRO E 245 -1  O  VAL E 244   N  ALA E 146           
SHEET    1  AB 2 VAL E 150  VAL E 152  0                                        
SHEET    2  AB 2 ILE E 158  ASN E 160 -1  O  VAL E 159   N  ILE E 151           
SHEET    1  AC 5 ARG E 250  TYR E 252  0                                        
SHEET    2  AC 5 MET E 258  GLY E 261 -1  O  MET E 258   N  TYR E 252           
SHEET    3  AC 5 GLU E 445  SER E 448 -1  O  GLU E 445   N  GLY E 261           
SHEET    4  AC 5 ALA E 436  LEU E 438 -1  N  LEU E 438   O  ILE E 446           
SHEET    5  AC 5 SER E 344  ALA E 345  1  N  SER E 344   O  LEU E 437           
SHEET    1  AD 2 ILE E 367  PHE E 369  0                                        
SHEET    2  AD 2 TRP E 403  THR E 405  1  O  GLN E 404   N  ILE E 367           
SHEET    1  AE 5 TYR F  77  ASN F  80  0                                        
SHEET    2  AE 5 GLY F  84  LEU F  89 -1  O  GLY F  84   N  ASN F  80           
SHEET    3  AE 5 CYS F 287  VAL F 292 -1  O  THR F 289   N  MET F  87           
SHEET    4  AE 5 LYS F 100  HIS F 105  1  N  LEU F 102   O  ILE F 290           
SHEET    5  AE 5 GLU F 337  MET F 338  1  O  GLU F 337   N  ILE F 101           
SHEET    1  AF 3 LEU F 118  GLU F 120  0                                        
SHEET    2  AF 3 ALA F 125  LEU F 127 -1  O  MET F 126   N  TYR F 119           
SHEET    3  AF 3 ASN F 200  LEU F 202 -1  O  LEU F 202   N  ALA F 125           
SHEET    1  AG 2 LEU F 145  ILE F 147  0                                        
SHEET    2  AG 2 ILE F 243  PRO F 245 -1  O  VAL F 244   N  ALA F 146           
SHEET    1  AH 2 VAL F 150  VAL F 152  0                                        
SHEET    2  AH 2 ILE F 158  ASN F 160 -1  O  VAL F 159   N  ILE F 151           
SHEET    1  AI 5 ARG F 250  TYR F 252  0                                        
SHEET    2  AI 5 MET F 258  GLY F 261 -1  O  MET F 258   N  TYR F 252           
SHEET    3  AI 5 GLU F 445  SER F 448 -1  O  GLU F 445   N  GLY F 261           
SHEET    4  AI 5 ALA F 436  LEU F 438 -1  N  LEU F 438   O  ILE F 446           
SHEET    5  AI 5 SER F 344  ALA F 345  1  N  SER F 344   O  LEU F 437           
SHEET    1  AJ 2 ILE F 367  PHE F 369  0                                        
SHEET    2  AJ 2 TRP F 403  THR F 405  1  O  GLN F 404   N  ILE F 367           
SHEET    1  AK 5 TYR G  77  ASN G  80  0                                        
SHEET    2  AK 5 GLY G  84  LEU G  89 -1  O  GLY G  84   N  ASN G  80           
SHEET    3  AK 5 CYS G 287  VAL G 292 -1  O  THR G 289   N  MET G  87           
SHEET    4  AK 5 LYS G 100  HIS G 105  1  N  LEU G 102   O  ILE G 290           
SHEET    5  AK 5 GLU G 337  MET G 338  1  O  GLU G 337   N  ILE G 101           
SHEET    1  AL 3 LEU G 118  GLU G 120  0                                        
SHEET    2  AL 3 ALA G 125  LEU G 127 -1  O  MET G 126   N  TYR G 119           
SHEET    3  AL 3 ASN G 200  LEU G 202 -1  O  LEU G 202   N  ALA G 125           
SHEET    1  AM 2 LEU G 145  ILE G 147  0                                        
SHEET    2  AM 2 ILE G 243  PRO G 245 -1  O  VAL G 244   N  ALA G 146           
SHEET    1  AN 2 VAL G 150  VAL G 152  0                                        
SHEET    2  AN 2 ILE G 158  ASN G 160 -1  O  VAL G 159   N  ILE G 151           
SHEET    1  AO 5 ARG G 250  TYR G 252  0                                        
SHEET    2  AO 5 MET G 258  GLY G 261 -1  O  MET G 258   N  TYR G 252           
SHEET    3  AO 5 GLU G 445  SER G 448 -1  O  GLU G 445   N  GLY G 261           
SHEET    4  AO 5 ALA G 436  LEU G 438 -1  N  LEU G 438   O  ILE G 446           
SHEET    5  AO 5 SER G 344  ALA G 345  1  N  SER G 344   O  LEU G 437           
SHEET    1  AP 2 ILE G 367  PHE G 369  0                                        
SHEET    2  AP 2 TRP G 403  THR G 405  1  O  GLN G 404   N  ILE G 367           
SHEET    1  AQ 5 TYR H  77  ASN H  80  0                                        
SHEET    2  AQ 5 GLY H  84  LEU H  89 -1  O  GLY H  84   N  ASN H  80           
SHEET    3  AQ 5 CYS H 287  VAL H 292 -1  O  THR H 289   N  MET H  87           
SHEET    4  AQ 5 LYS H 100  HIS H 105  1  N  LEU H 102   O  ILE H 290           
SHEET    5  AQ 5 GLU H 337  MET H 338  1  O  GLU H 337   N  ILE H 101           
SHEET    1  AR 3 LEU H 118  GLU H 120  0                                        
SHEET    2  AR 3 ALA H 125  LEU H 127 -1  O  MET H 126   N  TYR H 119           
SHEET    3  AR 3 ASN H 200  LEU H 202 -1  O  LEU H 202   N  ALA H 125           
SHEET    1  AS 2 LEU H 145  ILE H 147  0                                        
SHEET    2  AS 2 ILE H 243  PRO H 245 -1  O  VAL H 244   N  ALA H 146           
SHEET    1  AT 2 VAL H 150  VAL H 152  0                                        
SHEET    2  AT 2 ILE H 158  ASN H 160 -1  O  VAL H 159   N  ILE H 151           
SHEET    1  AU 5 ARG H 250  TYR H 252  0                                        
SHEET    2  AU 5 MET H 258  GLY H 261 -1  O  MET H 258   N  TYR H 252           
SHEET    3  AU 5 GLU H 445  SER H 448 -1  O  GLU H 445   N  GLY H 261           
SHEET    4  AU 5 ALA H 436  LEU H 438 -1  N  LEU H 438   O  ILE H 446           
SHEET    5  AU 5 SER H 344  ALA H 345  1  N  SER H 344   O  LEU H 437           
SHEET    1  AV 2 ILE H 367  PHE H 369  0                                        
SHEET    2  AV 2 TRP H 403  THR H 405  1  O  GLN H 404   N  ILE H 367           
SHEET    1  AW 5 TYR I  77  ASN I  80  0                                        
SHEET    2  AW 5 GLY I  84  LEU I  89 -1  O  GLY I  84   N  ASN I  80           
SHEET    3  AW 5 CYS I 287  VAL I 292 -1  O  THR I 289   N  MET I  87           
SHEET    4  AW 5 LYS I 100  HIS I 105  1  N  LEU I 102   O  ILE I 290           
SHEET    5  AW 5 GLU I 337  MET I 338  1  O  GLU I 337   N  ILE I 101           
SHEET    1  AX 3 LEU I 118  GLU I 120  0                                        
SHEET    2  AX 3 ALA I 125  LEU I 127 -1  O  MET I 126   N  TYR I 119           
SHEET    3  AX 3 ASN I 200  LEU I 202 -1  O  LEU I 202   N  ALA I 125           
SHEET    1  AY 2 LEU I 145  ILE I 147  0                                        
SHEET    2  AY 2 ILE I 243  PRO I 245 -1  O  VAL I 244   N  ALA I 146           
SHEET    1  AZ 2 VAL I 150  VAL I 152  0                                        
SHEET    2  AZ 2 ILE I 158  ASN I 160 -1  O  VAL I 159   N  ILE I 151           
SHEET    1  BA 5 ARG I 250  TYR I 252  0                                        
SHEET    2  BA 5 MET I 258  GLY I 261 -1  O  MET I 258   N  TYR I 252           
SHEET    3  BA 5 GLU I 445  SER I 448 -1  O  GLU I 445   N  GLY I 261           
SHEET    4  BA 5 ALA I 436  LEU I 438 -1  N  LEU I 438   O  ILE I 446           
SHEET    5  BA 5 SER I 344  ALA I 345  1  N  SER I 344   O  LEU I 437           
SHEET    1  BB 2 ILE I 367  PHE I 369  0                                        
SHEET    2  BB 2 TRP I 403  THR I 405  1  O  GLN I 404   N  ILE I 367           
SHEET    1  BC 5 TYR J  77  ASN J  80  0                                        
SHEET    2  BC 5 GLY J  84  LEU J  89 -1  O  GLY J  84   N  ASN J  80           
SHEET    3  BC 5 CYS J 287  VAL J 292 -1  O  THR J 289   N  MET J  87           
SHEET    4  BC 5 LYS J 100  HIS J 105  1  N  LEU J 102   O  ILE J 290           
SHEET    5  BC 5 GLU J 337  MET J 338  1  O  GLU J 337   N  ILE J 101           
SHEET    1  BD 3 LEU J 118  GLU J 120  0                                        
SHEET    2  BD 3 ALA J 125  LEU J 127 -1  O  MET J 126   N  TYR J 119           
SHEET    3  BD 3 ASN J 200  LEU J 202 -1  O  LEU J 202   N  ALA J 125           
SHEET    1  BE 2 LEU J 145  ILE J 147  0                                        
SHEET    2  BE 2 ILE J 243  PRO J 245 -1  O  VAL J 244   N  ALA J 146           
SHEET    1  BF 2 VAL J 150  VAL J 152  0                                        
SHEET    2  BF 2 ILE J 158  ASN J 160 -1  O  VAL J 159   N  ILE J 151           
SHEET    1  BG 5 ARG J 250  TYR J 252  0                                        
SHEET    2  BG 5 MET J 258  GLY J 261 -1  O  MET J 258   N  TYR J 252           
SHEET    3  BG 5 GLU J 445  SER J 448 -1  O  GLU J 445   N  GLY J 261           
SHEET    4  BG 5 ALA J 436  LEU J 438 -1  N  LEU J 438   O  ILE J 446           
SHEET    5  BG 5 SER J 344  ALA J 345  1  N  SER J 344   O  LEU J 437           
SHEET    1  BH 2 ILE J 367  PHE J 369  0                                        
SHEET    2  BH 2 TRP J 403  THR J 405  1  O  GLN J 404   N  ILE J 367           
SHEET    1  BI 5 TYR K  77  ASN K  80  0                                        
SHEET    2  BI 5 GLY K  84  LEU K  89 -1  O  GLY K  84   N  ASN K  80           
SHEET    3  BI 5 CYS K 287  VAL K 292 -1  O  THR K 289   N  MET K  87           
SHEET    4  BI 5 LYS K 100  HIS K 105  1  N  LEU K 102   O  ILE K 290           
SHEET    5  BI 5 GLU K 337  MET K 338  1  O  GLU K 337   N  ILE K 101           
SHEET    1  BJ 3 LEU K 118  GLU K 120  0                                        
SHEET    2  BJ 3 ALA K 125  LEU K 127 -1  O  MET K 126   N  TYR K 119           
SHEET    3  BJ 3 ASN K 200  LEU K 202 -1  O  LEU K 202   N  ALA K 125           
SHEET    1  BK 2 LEU K 145  ILE K 147  0                                        
SHEET    2  BK 2 ILE K 243  PRO K 245 -1  O  VAL K 244   N  ALA K 146           
SHEET    1  BL 2 VAL K 150  VAL K 152  0                                        
SHEET    2  BL 2 ILE K 158  ASN K 160 -1  O  VAL K 159   N  ILE K 151           
SHEET    1  BM 5 ARG K 250  TYR K 252  0                                        
SHEET    2  BM 5 MET K 258  GLY K 261 -1  O  MET K 258   N  TYR K 252           
SHEET    3  BM 5 GLU K 445  SER K 448 -1  O  GLU K 445   N  GLY K 261           
SHEET    4  BM 5 ALA K 436  LEU K 438 -1  N  LEU K 438   O  ILE K 446           
SHEET    5  BM 5 SER K 344  ALA K 345  1  N  SER K 344   O  LEU K 437           
SHEET    1  BN 2 ILE K 367  PHE K 369  0                                        
SHEET    2  BN 2 TRP K 403  THR K 405  1  O  GLN K 404   N  ILE K 367           
SHEET    1  BO 5 TYR L  77  ASN L  80  0                                        
SHEET    2  BO 5 GLY L  84  LEU L  89 -1  O  GLY L  84   N  ASN L  80           
SHEET    3  BO 5 CYS L 287  VAL L 292 -1  O  THR L 289   N  MET L  87           
SHEET    4  BO 5 LYS L 100  HIS L 105  1  N  LEU L 102   O  ILE L 290           
SHEET    5  BO 5 GLU L 337  MET L 338  1  O  GLU L 337   N  ILE L 101           
SHEET    1  BP 3 LEU L 118  GLU L 120  0                                        
SHEET    2  BP 3 ALA L 125  LEU L 127 -1  O  MET L 126   N  TYR L 119           
SHEET    3  BP 3 ASN L 200  LEU L 202 -1  O  LEU L 202   N  ALA L 125           
SHEET    1  BQ 2 LEU L 145  ILE L 147  0                                        
SHEET    2  BQ 2 ILE L 243  PRO L 245 -1  O  VAL L 244   N  ALA L 146           
SHEET    1  BR 2 VAL L 150  VAL L 152  0                                        
SHEET    2  BR 2 ILE L 158  ASN L 160 -1  O  VAL L 159   N  ILE L 151           
SHEET    1  BS 5 ARG L 250  TYR L 252  0                                        
SHEET    2  BS 5 MET L 258  GLY L 261 -1  O  MET L 258   N  TYR L 252           
SHEET    3  BS 5 GLU L 445  SER L 448 -1  O  GLU L 445   N  GLY L 261           
SHEET    4  BS 5 ALA L 436  LEU L 438 -1  N  LEU L 438   O  ILE L 446           
SHEET    5  BS 5 SER L 344  ALA L 345  1  N  SER L 344   O  LEU L 437           
SHEET    1  BT 2 ILE L 367  PHE L 369  0                                        
SHEET    2  BT 2 TRP L 403  THR L 405  1  O  GLN L 404   N  ILE L 367           
SHEET    1  BU 5 TYR M  77  ASN M  80  0                                        
SHEET    2  BU 5 GLY M  84  LEU M  89 -1  O  GLY M  84   N  ASN M  80           
SHEET    3  BU 5 CYS M 287  VAL M 292 -1  O  THR M 289   N  MET M  87           
SHEET    4  BU 5 LYS M 100  HIS M 105  1  N  LEU M 102   O  ILE M 290           
SHEET    5  BU 5 GLU M 337  MET M 338  1  O  GLU M 337   N  ILE M 101           
SHEET    1  BV 3 LEU M 118  GLU M 120  0                                        
SHEET    2  BV 3 ALA M 125  LEU M 127 -1  O  MET M 126   N  TYR M 119           
SHEET    3  BV 3 ASN M 200  LEU M 202 -1  O  LEU M 202   N  ALA M 125           
SHEET    1  BW 2 LEU M 145  ILE M 147  0                                        
SHEET    2  BW 2 ILE M 243  PRO M 245 -1  O  VAL M 244   N  ALA M 146           
SHEET    1  BX 2 VAL M 150  VAL M 152  0                                        
SHEET    2  BX 2 ILE M 158  ASN M 160 -1  O  VAL M 159   N  ILE M 151           
SHEET    1  BY 5 ARG M 250  TYR M 252  0                                        
SHEET    2  BY 5 MET M 258  GLY M 261 -1  O  MET M 258   N  TYR M 252           
SHEET    3  BY 5 GLU M 445  SER M 448 -1  O  GLU M 445   N  GLY M 261           
SHEET    4  BY 5 ALA M 436  LEU M 438 -1  N  LEU M 438   O  ILE M 446           
SHEET    5  BY 5 SER M 344  ALA M 345  1  N  SER M 344   O  LEU M 437           
SHEET    1  BZ 2 ILE M 367  PHE M 369  0                                        
SHEET    2  BZ 2 TRP M 403  THR M 405  1  O  GLN M 404   N  ILE M 367           
SHEET    1  CA 5 TYR N  77  ASN N  80  0                                        
SHEET    2  CA 5 GLY N  84  LEU N  89 -1  O  GLY N  84   N  ASN N  80           
SHEET    3  CA 5 CYS N 287  VAL N 292 -1  O  THR N 289   N  MET N  87           
SHEET    4  CA 5 LYS N 100  HIS N 105  1  N  LEU N 102   O  ILE N 290           
SHEET    5  CA 5 GLU N 337  MET N 338  1  O  GLU N 337   N  ILE N 101           
SHEET    1  CB 3 LEU N 118  GLU N 120  0                                        
SHEET    2  CB 3 ALA N 125  LEU N 127 -1  O  MET N 126   N  TYR N 119           
SHEET    3  CB 3 ASN N 200  LEU N 202 -1  O  LEU N 202   N  ALA N 125           
SHEET    1  CC 2 LEU N 145  ILE N 147  0                                        
SHEET    2  CC 2 ILE N 243  PRO N 245 -1  O  VAL N 244   N  ALA N 146           
SHEET    1  CD 2 VAL N 150  VAL N 152  0                                        
SHEET    2  CD 2 ILE N 158  ASN N 160 -1  O  VAL N 159   N  ILE N 151           
SHEET    1  CE 5 ARG N 250  TYR N 252  0                                        
SHEET    2  CE 5 MET N 258  GLY N 261 -1  O  MET N 258   N  TYR N 252           
SHEET    3  CE 5 GLU N 445  SER N 448 -1  O  GLU N 445   N  GLY N 261           
SHEET    4  CE 5 ALA N 436  LEU N 438 -1  N  LEU N 438   O  ILE N 446           
SHEET    5  CE 5 SER N 344  ALA N 345  1  N  SER N 344   O  LEU N 437           
SHEET    1  CF 2 ILE N 367  PHE N 369  0                                        
SHEET    2  CF 2 TRP N 403  THR N 405  1  O  GLN N 404   N  ILE N 367           
SHEET    1  CG 5 TYR O  77  ASN O  80  0                                        
SHEET    2  CG 5 GLY O  84  MET O  87 -1  O  GLY O  84   N  ASN O  80           
SHEET    3  CG 5 CYS O 287  VAL O 292 -1  O  THR O 289   N  MET O  87           
SHEET    4  CG 5 LYS O 100  HIS O 105  1  N  LEU O 102   O  ILE O 290           
SHEET    5  CG 5 GLU O 337  MET O 338  1  O  GLU O 337   N  ILE O 101           
SHEET    1  CH 3 LEU O 118  GLU O 120  0                                        
SHEET    2  CH 3 ALA O 125  LEU O 127 -1  O  MET O 126   N  TYR O 119           
SHEET    3  CH 3 ASN O 200  LEU O 202 -1  O  LEU O 202   N  ALA O 125           
SHEET    1  CI 2 LEU O 145  ILE O 147  0                                        
SHEET    2  CI 2 ILE O 243  PRO O 245 -1  O  VAL O 244   N  ALA O 146           
SHEET    1  CJ 2 VAL O 150  VAL O 152  0                                        
SHEET    2  CJ 2 ILE O 158  ASN O 160 -1  O  VAL O 159   N  ILE O 151           
SHEET    1  CK 5 ARG O 250  TYR O 252  0                                        
SHEET    2  CK 5 MET O 258  GLY O 261 -1  O  MET O 258   N  TYR O 252           
SHEET    3  CK 5 GLU O 445  SER O 448 -1  O  GLU O 445   N  GLY O 261           
SHEET    4  CK 5 ALA O 436  LEU O 438 -1  N  LEU O 438   O  ILE O 446           
SHEET    5  CK 5 SER O 344  ALA O 345  1  N  SER O 344   O  LEU O 437           
SHEET    1  CL 2 ILE O 367  PHE O 369  0                                        
SHEET    2  CL 2 TRP O 403  THR O 405  1  O  GLN O 404   N  ILE O 367           
SHEET    1  CM 5 TYR P  77  ASN P  80  0                                        
SHEET    2  CM 5 GLY P  84  LEU P  89 -1  O  GLY P  84   N  ASN P  80           
SHEET    3  CM 5 CYS P 287  VAL P 292 -1  O  THR P 289   N  MET P  87           
SHEET    4  CM 5 LYS P 100  HIS P 105  1  N  LEU P 102   O  ILE P 290           
SHEET    5  CM 5 GLU P 337  MET P 338  1  O  GLU P 337   N  ILE P 101           
SHEET    1  CN 3 LEU P 118  GLU P 120  0                                        
SHEET    2  CN 3 ALA P 125  LEU P 127 -1  O  MET P 126   N  TYR P 119           
SHEET    3  CN 3 ASN P 200  LEU P 202 -1  O  LEU P 202   N  ALA P 125           
SHEET    1  CO 2 LEU P 145  ILE P 147  0                                        
SHEET    2  CO 2 ILE P 243  PRO P 245 -1  O  VAL P 244   N  ALA P 146           
SHEET    1  CP 2 VAL P 150  VAL P 152  0                                        
SHEET    2  CP 2 ILE P 158  ASN P 160 -1  O  VAL P 159   N  ILE P 151           
SHEET    1  CQ 5 ARG P 250  TYR P 252  0                                        
SHEET    2  CQ 5 MET P 258  GLY P 261 -1  O  MET P 258   N  TYR P 252           
SHEET    3  CQ 5 GLU P 445  SER P 448 -1  O  GLU P 445   N  GLY P 261           
SHEET    4  CQ 5 ALA P 436  LEU P 438 -1  N  LEU P 438   O  ILE P 446           
SHEET    5  CQ 5 SER P 344  ALA P 345  1  N  SER P 344   O  LEU P 437           
SHEET    1  CR 2 ILE P 367  PHE P 369  0                                        
SHEET    2  CR 2 TRP P 403  THR P 405  1  O  GLN P 404   N  ILE P 367           
SHEET    1  CS 5 TYR Q  77  ASN Q  80  0                                        
SHEET    2  CS 5 GLY Q  84  LEU Q  89 -1  O  GLY Q  84   N  ASN Q  80           
SHEET    3  CS 5 CYS Q 287  VAL Q 292 -1  O  THR Q 289   N  MET Q  87           
SHEET    4  CS 5 LYS Q 100  HIS Q 105  1  N  LEU Q 102   O  ILE Q 290           
SHEET    5  CS 5 GLU Q 337  MET Q 338  1  O  GLU Q 337   N  ILE Q 101           
SHEET    1  CT 3 LEU Q 118  GLU Q 120  0                                        
SHEET    2  CT 3 ALA Q 125  LEU Q 127 -1  O  MET Q 126   N  TYR Q 119           
SHEET    3  CT 3 ASN Q 200  LEU Q 202 -1  O  LEU Q 202   N  ALA Q 125           
SHEET    1  CU 2 LEU Q 145  ILE Q 147  0                                        
SHEET    2  CU 2 ILE Q 243  PRO Q 245 -1  O  VAL Q 244   N  ALA Q 146           
SHEET    1  CV 2 VAL Q 150  VAL Q 152  0                                        
SHEET    2  CV 2 ILE Q 158  ASN Q 160 -1  O  VAL Q 159   N  ILE Q 151           
SHEET    1  CW 5 ARG Q 250  TYR Q 252  0                                        
SHEET    2  CW 5 MET Q 258  GLY Q 261 -1  O  MET Q 258   N  TYR Q 252           
SHEET    3  CW 5 GLU Q 445  SER Q 448 -1  O  GLU Q 445   N  GLY Q 261           
SHEET    4  CW 5 ALA Q 436  LEU Q 438 -1  N  LEU Q 438   O  ILE Q 446           
SHEET    5  CW 5 SER Q 344  ALA Q 345  1  N  SER Q 344   O  LEU Q 437           
SHEET    1  CX 2 ILE Q 367  PHE Q 369  0                                        
SHEET    2  CX 2 TRP Q 403  THR Q 405  1  O  GLN Q 404   N  ILE Q 367           
SHEET    1  CY 5 TYR R  77  ASN R  80  0                                        
SHEET    2  CY 5 GLY R  84  LEU R  89 -1  O  GLY R  84   N  ASN R  80           
SHEET    3  CY 5 CYS R 287  VAL R 292 -1  O  THR R 289   N  MET R  87           
SHEET    4  CY 5 LYS R 100  HIS R 105  1  N  LEU R 102   O  ILE R 290           
SHEET    5  CY 5 GLU R 337  MET R 338  1  O  GLU R 337   N  ILE R 101           
SHEET    1  CZ 3 LEU R 118  GLU R 120  0                                        
SHEET    2  CZ 3 ALA R 125  LEU R 127 -1  O  MET R 126   N  TYR R 119           
SHEET    3  CZ 3 ASN R 200  LEU R 202 -1  O  LEU R 202   N  ALA R 125           
SHEET    1  DA 2 LEU R 145  ILE R 147  0                                        
SHEET    2  DA 2 ILE R 243  PRO R 245 -1  O  VAL R 244   N  ALA R 146           
SHEET    1  DB 2 VAL R 150  VAL R 152  0                                        
SHEET    2  DB 2 ILE R 158  ASN R 160 -1  O  VAL R 159   N  ILE R 151           
SHEET    1  DC 5 ARG R 250  TYR R 252  0                                        
SHEET    2  DC 5 MET R 258  GLY R 261 -1  O  MET R 258   N  TYR R 252           
SHEET    3  DC 5 GLU R 445  SER R 448 -1  O  GLU R 445   N  GLY R 261           
SHEET    4  DC 5 ALA R 436  LEU R 438 -1  N  LEU R 438   O  ILE R 446           
SHEET    5  DC 5 SER R 344  ALA R 345  1  N  SER R 344   O  LEU R 437           
SHEET    1  DD 2 ILE R 367  PHE R 369  0                                        
SHEET    2  DD 2 TRP R 403  THR R 405  1  O  GLN R 404   N  ILE R 367           
SHEET    1  DE 5 TYR S  77  ASN S  80  0                                        
SHEET    2  DE 5 GLY S  84  LEU S  89 -1  O  GLY S  84   N  ASN S  80           
SHEET    3  DE 5 CYS S 287  VAL S 292 -1  O  THR S 289   N  MET S  87           
SHEET    4  DE 5 LYS S 100  HIS S 105  1  N  LEU S 102   O  ILE S 290           
SHEET    5  DE 5 GLU S 337  MET S 338  1  O  GLU S 337   N  ILE S 101           
SHEET    1  DF 3 LEU S 118  GLU S 120  0                                        
SHEET    2  DF 3 ALA S 125  LEU S 127 -1  O  MET S 126   N  TYR S 119           
SHEET    3  DF 3 ASN S 200  LEU S 202 -1  O  LEU S 202   N  ALA S 125           
SHEET    1  DG 2 LEU S 145  ILE S 147  0                                        
SHEET    2  DG 2 ILE S 243  PRO S 245 -1  O  VAL S 244   N  ALA S 146           
SHEET    1  DH 2 VAL S 150  VAL S 152  0                                        
SHEET    2  DH 2 ILE S 158  ASN S 160 -1  O  VAL S 159   N  ILE S 151           
SHEET    1  DI 5 ARG S 250  TYR S 252  0                                        
SHEET    2  DI 5 MET S 258  GLY S 261 -1  O  MET S 258   N  TYR S 252           
SHEET    3  DI 5 GLU S 445  SER S 448 -1  O  GLU S 445   N  GLY S 261           
SHEET    4  DI 5 ALA S 436  LEU S 438 -1  N  LEU S 438   O  ILE S 446           
SHEET    5  DI 5 SER S 344  ALA S 345  1  N  SER S 344   O  LEU S 437           
SHEET    1  DJ 2 ILE S 367  PHE S 369  0                                        
SHEET    2  DJ 2 TRP S 403  THR S 405  1  O  GLN S 404   N  ILE S 367           
SHEET    1  DK 5 TYR T  77  ASN T  80  0                                        
SHEET    2  DK 5 GLY T  84  LEU T  89 -1  O  GLY T  84   N  ASN T  80           
SHEET    3  DK 5 CYS T 287  VAL T 292 -1  O  THR T 289   N  MET T  87           
SHEET    4  DK 5 LYS T 100  HIS T 105  1  N  LEU T 102   O  ILE T 290           
SHEET    5  DK 5 GLU T 337  MET T 338  1  O  GLU T 337   N  ILE T 101           
SHEET    1  DL 3 LEU T 118  GLU T 120  0                                        
SHEET    2  DL 3 ALA T 125  LEU T 127 -1  O  MET T 126   N  TYR T 119           
SHEET    3  DL 3 ASN T 200  LEU T 202 -1  O  LEU T 202   N  ALA T 125           
SHEET    1  DM 2 LEU T 145  ILE T 147  0                                        
SHEET    2  DM 2 ILE T 243  PRO T 245 -1  O  VAL T 244   N  ALA T 146           
SHEET    1  DN 2 VAL T 150  VAL T 152  0                                        
SHEET    2  DN 2 ILE T 158  ASN T 160 -1  O  VAL T 159   N  ILE T 151           
SHEET    1  DO 5 ARG T 250  TYR T 252  0                                        
SHEET    2  DO 5 MET T 258  GLY T 261 -1  O  MET T 258   N  TYR T 252           
SHEET    3  DO 5 GLU T 445  SER T 448 -1  O  GLU T 445   N  GLY T 261           
SHEET    4  DO 5 ALA T 436  LEU T 438 -1  N  LEU T 438   O  ILE T 446           
SHEET    5  DO 5 SER T 344  ALA T 345  1  N  SER T 344   O  LEU T 437           
SHEET    1  DP 2 ILE T 367  PHE T 369  0                                        
SHEET    2  DP 2 TRP T 403  THR T 405  1  O  GLN T 404   N  ILE T 367           
SHEET    1  DQ 5 TYR U  77  ASN U  80  0                                        
SHEET    2  DQ 5 GLY U  84  MET U  87 -1  O  GLY U  84   N  ASN U  80           
SHEET    3  DQ 5 CYS U 287  VAL U 292 -1  O  THR U 289   N  MET U  87           
SHEET    4  DQ 5 LYS U 100  HIS U 105  1  N  LEU U 102   O  ILE U 290           
SHEET    5  DQ 5 GLU U 337  MET U 338  1  O  GLU U 337   N  ILE U 101           
SHEET    1  DR 3 LEU U 118  GLU U 120  0                                        
SHEET    2  DR 3 ALA U 125  LEU U 127 -1  O  MET U 126   N  TYR U 119           
SHEET    3  DR 3 ASN U 200  LEU U 202 -1  O  LEU U 202   N  ALA U 125           
SHEET    1  DS 2 LEU U 145  ILE U 147  0                                        
SHEET    2  DS 2 ILE U 243  PRO U 245 -1  O  VAL U 244   N  ALA U 146           
SHEET    1  DT 2 VAL U 150  VAL U 152  0                                        
SHEET    2  DT 2 ILE U 158  ASN U 160 -1  O  VAL U 159   N  ILE U 151           
SHEET    1  DU 5 ARG U 250  TYR U 252  0                                        
SHEET    2  DU 5 MET U 258  GLY U 261 -1  O  MET U 258   N  TYR U 252           
SHEET    3  DU 5 GLU U 445  SER U 448 -1  O  GLU U 445   N  GLY U 261           
SHEET    4  DU 5 ALA U 436  LEU U 438 -1  N  LEU U 438   O  ILE U 446           
SHEET    5  DU 5 SER U 344  ALA U 345  1  N  SER U 344   O  LEU U 437           
SHEET    1  DV 2 ILE U 367  PHE U 369  0                                        
SHEET    2  DV 2 TRP U 403  THR U 405  1  O  GLN U 404   N  ILE U 367           
SHEET    1  DW 5 TYR V  77  ASN V  80  0                                        
SHEET    2  DW 5 GLY V  84  LEU V  89 -1  O  GLY V  84   N  ASN V  80           
SHEET    3  DW 5 CYS V 287  VAL V 292 -1  O  THR V 289   N  MET V  87           
SHEET    4  DW 5 LYS V 100  HIS V 105  1  N  LEU V 102   O  ILE V 290           
SHEET    5  DW 5 GLU V 337  MET V 338  1  O  GLU V 337   N  ILE V 101           
SHEET    1  DX 3 LEU V 118  GLU V 120  0                                        
SHEET    2  DX 3 ALA V 125  LEU V 127 -1  O  MET V 126   N  TYR V 119           
SHEET    3  DX 3 ASN V 200  LEU V 202 -1  O  LEU V 202   N  ALA V 125           
SHEET    1  DY 2 LEU V 145  ILE V 147  0                                        
SHEET    2  DY 2 ILE V 243  PRO V 245 -1  O  VAL V 244   N  ALA V 146           
SHEET    1  DZ 2 VAL V 150  VAL V 152  0                                        
SHEET    2  DZ 2 ILE V 158  ASN V 160 -1  O  VAL V 159   N  ILE V 151           
SHEET    1  EA 5 ARG V 250  TYR V 252  0                                        
SHEET    2  EA 5 MET V 258  GLY V 261 -1  O  MET V 258   N  TYR V 252           
SHEET    3  EA 5 GLU V 445  SER V 448 -1  O  GLU V 445   N  GLY V 261           
SHEET    4  EA 5 ALA V 436  LEU V 438 -1  N  LEU V 438   O  ILE V 446           
SHEET    5  EA 5 SER V 344  ALA V 345  1  N  SER V 344   O  LEU V 437           
SHEET    1  EB 2 ILE V 367  PHE V 369  0                                        
SHEET    2  EB 2 TRP V 403  THR V 405  1  O  GLN V 404   N  ILE V 367           
SHEET    1  EC 5 TYR W  77  ASN W  80  0                                        
SHEET    2  EC 5 GLY W  84  LEU W  89 -1  O  GLY W  84   N  ASN W  80           
SHEET    3  EC 5 CYS W 287  VAL W 292 -1  O  THR W 289   N  MET W  87           
SHEET    4  EC 5 LYS W 100  HIS W 105  1  N  LEU W 102   O  ILE W 290           
SHEET    5  EC 5 GLU W 337  MET W 338  1  O  GLU W 337   N  ILE W 101           
SHEET    1  ED 3 LEU W 118  GLU W 120  0                                        
SHEET    2  ED 3 ALA W 125  LEU W 127 -1  O  MET W 126   N  TYR W 119           
SHEET    3  ED 3 ASN W 200  LEU W 202 -1  O  LEU W 202   N  ALA W 125           
SHEET    1  EE 2 LEU W 145  ILE W 147  0                                        
SHEET    2  EE 2 ILE W 243  PRO W 245 -1  O  VAL W 244   N  ALA W 146           
SHEET    1  EF 2 VAL W 150  VAL W 152  0                                        
SHEET    2  EF 2 ILE W 158  ASN W 160 -1  O  VAL W 159   N  ILE W 151           
SHEET    1  EG 5 ARG W 250  TYR W 252  0                                        
SHEET    2  EG 5 MET W 258  GLY W 261 -1  O  MET W 258   N  TYR W 252           
SHEET    3  EG 5 GLU W 445  SER W 448 -1  O  GLU W 445   N  GLY W 261           
SHEET    4  EG 5 ALA W 436  LEU W 438 -1  N  LEU W 438   O  ILE W 446           
SHEET    5  EG 5 SER W 344  ALA W 345  1  N  SER W 344   O  LEU W 437           
SHEET    1  EH 2 ILE W 367  PHE W 369  0                                        
SHEET    2  EH 2 TRP W 403  THR W 405  1  O  GLN W 404   N  ILE W 367           
SHEET    1  EI 5 TYR X  77  ASN X  80  0                                        
SHEET    2  EI 5 GLY X  84  LEU X  89 -1  O  GLY X  84   N  ASN X  80           
SHEET    3  EI 5 CYS X 287  VAL X 292 -1  O  THR X 289   N  MET X  87           
SHEET    4  EI 5 LYS X 100  HIS X 105  1  N  LEU X 102   O  ILE X 290           
SHEET    5  EI 5 GLU X 337  SER X 340  1  O  GLU X 337   N  ILE X 101           
SHEET    1  EJ 3 LEU X 118  GLU X 120  0                                        
SHEET    2  EJ 3 ALA X 125  LEU X 127 -1  O  MET X 126   N  TYR X 119           
SHEET    3  EJ 3 ASN X 200  LEU X 202 -1  O  LEU X 202   N  ALA X 125           
SHEET    1  EK 2 LEU X 145  ILE X 147  0                                        
SHEET    2  EK 2 ILE X 243  PRO X 245 -1  O  VAL X 244   N  ALA X 146           
SHEET    1  EL 2 VAL X 150  VAL X 152  0                                        
SHEET    2  EL 2 ILE X 158  ASN X 160 -1  O  VAL X 159   N  ILE X 151           
SHEET    1  EM 5 ARG X 250  TYR X 252  0                                        
SHEET    2  EM 5 MET X 258  GLY X 261 -1  O  MET X 258   N  TYR X 252           
SHEET    3  EM 5 GLU X 445  SER X 448 -1  O  GLU X 445   N  GLY X 261           
SHEET    4  EM 5 ALA X 436  LEU X 438 -1  N  LEU X 438   O  ILE X 446           
SHEET    5  EM 5 SER X 344  ALA X 345  1  N  SER X 344   O  LEU X 437           
SHEET    1  EN 2 ILE X 367  PHE X 369  0                                        
SHEET    2  EN 2 TRP X 403  THR X 405  1  O  GLN X 404   N  ILE X 367           
LINK         C   ASN A 439                 N   MSE A 440     1555   1555  1.33  
LINK         C   MSE A 440                 N   HIS A 441     1555   1555  1.33  
LINK        MN    MN A6001                 OE2 GLU A 296     1555   1555  2.67  
LINK        MN    MN A6001                 O   HOH A6108     1555   1555  2.31  
LINK        MN    MN A6001                 OE1 GLU A 296     1555   1555  2.22  
LINK        MN    MN A6001                MN    MN A6002     1555   1555  2.49  
LINK        MN    MN A6002                 OD2 ASP A 342     1555   1555  2.41  
LINK        MN    MN A6002                 OD1 ASP A 342     1555   1555  2.20  
LINK        MN    MN A6002                 OD1 ASP A 265     1555   1555  2.54  
LINK        MN    MN A6002                 NE2 HIS A 105     1555   1555  2.19  
LINK         C   ASN B 439                 N   MSE B 440     1555   1555  1.33  
LINK         C   MSE B 440                 N   HIS B 441     1555   1555  1.33  
LINK        MN    MN B6003                 OE1 GLU B 296     1555   1555  2.37  
LINK        MN    MN B6003                 OE2 GLU B 296     1555   1555  2.29  
LINK        MN    MN B6003                 NE2 HIS B 441     1555   1555  2.62  
LINK        MN    MN B6004                 OD1 ASP B 265     1555   1555  2.47  
LINK        MN    MN B6004                 OD2 ASP B 342     1555   1555  2.31  
LINK        MN    MN B6004                 NE2 HIS B 105     1555   1555  2.17  
LINK        MN    MN B6004                 OD1 ASP B 342     1555   1555  2.22  
LINK         C   ASN C 439                 N   MSE C 440     1555   1555  1.33  
LINK         C   MSE C 440                 N   HIS C 441     1555   1555  1.33  
LINK        MN    MN C6005                 OE1 GLU C 296     1555   1555  2.36  
LINK        MN    MN C6005                 NE2 HIS C 441     1555   1555  2.61  
LINK        MN    MN C6005                 OE2 GLU C 296     1555   1555  2.35  
LINK        MN    MN C6006                 NE2 HIS C 105     1555   1555  2.57  
LINK        MN    MN C6006                 OD1 ASP C 342     1555   1555  2.36  
LINK        MN    MN C6006                 OD2 ASP C 342     1555   1555  2.33  
LINK        MN    MN C6006                 OD1 ASP C 265     1555   1555  2.36  
LINK         C   ASN D 439                 N   MSE D 440     1555   1555  1.33  
LINK         C   MSE D 440                 N   HIS D 441     1555   1555  1.32  
LINK        MN    MN D6007                 OE2 GLU D 296     1555   1555  2.21  
LINK        MN    MN D6007                 NE2 HIS D 441     1555   1555  2.52  
LINK        MN    MN D6007                 OE1 GLU D 296     1555   1555  2.18  
LINK        MN    MN D6008                 NE2 HIS D 105     1555   1555  2.39  
LINK        MN    MN D6008                 OD1 ASP D 342     1555   1555  2.35  
LINK        MN    MN D6008                 OD2 ASP D 342     1555   1555  2.30  
LINK        MN    MN D6008                 OD1 ASP D 265     1555   1555  2.29  
LINK         C   ASN E 439                 N   MSE E 440     1555   1555  1.33  
LINK         C   MSE E 440                 N   HIS E 441     1555   1555  1.33  
LINK        MN    MN E6009                 OE2 GLU E 296     1555   1555  2.70  
LINK        MN    MN E6009                 OE1 GLU E 296     1555   1555  2.28  
LINK        MN    MN E6009                 NE2 HIS E 441     1555   1555  2.63  
LINK        MN    MN E6009                 O   HOH E6203     1555   1555  2.41  
LINK        MN    MN E6009                MN    MN E6010     1555   1555  2.67  
LINK        MN    MN E6010                 NE2 HIS E 105     1555   1555  2.28  
LINK        MN    MN E6010                 OD1 ASP E 265     1555   1555  2.17  
LINK        MN    MN E6010                 OD1 ASP E 342     1555   1555  2.46  
LINK        MN    MN E6010                 OD2 ASP E 342     1555   1555  2.32  
LINK         C   ASN F 439                 N   MSE F 440     1555   1555  1.33  
LINK         C   MSE F 440                 N   HIS F 441     1555   1555  1.32  
LINK        MN    MN F6011                 OE1 GLU F 296     1555   1555  2.42  
LINK        MN    MN F6011                 OE2 GLU F 296     1555   1555  2.70  
LINK        MN    MN F6011                 NE2 HIS F 441     1555   1555  2.32  
LINK        MN    MN F6012                 OD1 ASP F 342     1555   1555  2.40  
LINK        MN    MN F6012                 O   HOH F6021     1555   1555  2.50  
LINK        MN    MN F6012                 NE2 HIS F 105     1555   1555  2.52  
LINK        MN    MN F6012                 OD1 ASP F 265     1555   1555  2.26  
LINK        MN    MN F6012                 OD2 ASP F 342     1555   1555  2.33  
LINK         C   ASN G 439                 N   MSE G 440     1555   1555  1.33  
LINK         C   MSE G 440                 N   HIS G 441     1555   1555  1.33  
LINK        MN    MN G6013                 O   HOH G6040     1555   1555  2.56  
LINK        MN    MN G6013                 OE1 GLU G 296     1555   1555  2.33  
LINK        MN    MN G6013                MN    MN G6014     1555   1555  2.57  
LINK        MN    MN G6014                 NE2 HIS G 105     1555   1555  2.14  
LINK        MN    MN G6014                 OD1 ASP G 265     1555   1555  2.25  
LINK        MN    MN G6014                 OD2 ASP G 342     1555   1555  2.09  
LINK        MN    MN G6014                 OD1 ASP G 342     1555   1555  2.28  
LINK         C   ASN H 439                 N   MSE H 440     1555   1555  1.33  
LINK         C   MSE H 440                 N   HIS H 441     1555   1555  1.33  
LINK        MN    MN H6015                 NE2 HIS H 441     1555   1555  2.71  
LINK        MN    MN H6015                 OE1 GLU H 296     1555   1555  2.28  
LINK        MN    MN H6015                 OE2 GLU H 296     1555   1555  2.58  
LINK        MN    MN H6015                MN    MN H6016     1555   1555  2.65  
LINK        MN    MN H6016                 OD1 ASP H 265     1555   1555  2.38  
LINK        MN    MN H6016                 NE2 HIS H 105     1555   1555  2.65  
LINK        MN    MN H6016                 OD1 ASP H 342     1555   1555  2.21  
LINK        MN    MN H6016                 OD2 ASP H 342     1555   1555  2.16  
LINK         C   ASN I 439                 N   MSE I 440     1555   1555  1.33  
LINK         C   MSE I 440                 N   HIS I 441     1555   1555  1.33  
LINK        MN    MN I6017                 OE2 GLU I 296     1555   1555  2.62  
LINK        MN    MN I6017                 OE1 GLU I 296     1555   1555  2.20  
LINK        MN    MN I6017                 NE2 HIS I 441     1555   1555  2.68  
LINK        MN    MN I6017                MN    MN I6018     1555   1555  2.67  
LINK        MN    MN I6018                 OD1 ASP I 265     1555   1555  2.66  
LINK        MN    MN I6018                 OD2 ASP I 342     1555   1555  2.40  
LINK        MN    MN I6018                 O   HOH I6115     1555   1555  2.13  
LINK        MN    MN I6018                 NE2 HIS I 105     1555   1555  2.33  
LINK        MN    MN I6018                 OD1 ASP I 342     1555   1555  2.11  
LINK         C   ASN J 439                 N   MSE J 440     1555   1555  1.33  
LINK         C   MSE J 440                 N   HIS J 441     1555   1555  1.33  
LINK        MN    MN J6019                 O   HOH J6023     1555   1555  2.35  
LINK        MN    MN J6019                 OE1 GLU J 296     1555   1555  2.31  
LINK        MN    MN J6019                 OE2 GLU J 296     1555   1555  2.53  
LINK        MN    MN J6019                 NE2 HIS J 441     1555   1555  2.39  
LINK        MN    MN J6020                 NE2 HIS J 105     1555   1555  2.43  
LINK        MN    MN J6020                 OD1 ASP J 342     1555   1555  2.20  
LINK        MN    MN J6020                 OD2 ASP J 342     1555   1555  2.19  
LINK        MN    MN J6020                 OD1 ASP J 265     1555   1555  2.35  
LINK         C   ASN K 439                 N   MSE K 440     1555   1555  1.33  
LINK         C   MSE K 440                 N   HIS K 441     1555   1555  1.33  
LINK        MN    MN K6021                 OE1 GLU K 296     1555   1555  2.34  
LINK        MN    MN K6021                 OE2 GLU K 296     1555   1555  2.60  
LINK        MN    MN K6021                 NE2 HIS K 441     1555   1555  2.39  
LINK        MN    MN K6022                 NE2 HIS K 105     1555   1555  2.46  
LINK        MN    MN K6022                 OD1 ASP K 265     1555   1555  2.62  
LINK        MN    MN K6022                 OD2 ASP K 342     1555   1555  2.49  
LINK        MN    MN K6022                 OD1 ASP K 342     1555   1555  2.19  
LINK         C   ASN L 439                 N   MSE L 440     1555   1555  1.33  
LINK         C   MSE L 440                 N   HIS L 441     1555   1555  1.33  
LINK        MN    MN L6023                 OD2 ASP L 265     1555   1555  2.68  
LINK        MN    MN L6023                 NE2 HIS L 441     1555   1555  2.32  
LINK        MN    MN L6023                 OE1 GLU L 296     1555   1555  2.19  
LINK        MN    MN L6023                 OE2 GLU L 296     1555   1555  2.62  
LINK        MN    MN L6023                 O   HOH L6116     1555   1555  2.56  
LINK        MN    MN L6024                 OD2 ASP L 342     1555   1555  2.20  
LINK        MN    MN L6024                 OD1 ASP L 342     1555   1555  2.18  
LINK        MN    MN L6024                 NE2 HIS L 105     1555   1555  2.47  
LINK        MN    MN L6024                 OD1 ASP L 265     1555   1555  2.45  
LINK         C   ASN M 439                 N   MSE M 440     1555   1555  1.33  
LINK         C   MSE M 440                 N   HIS M 441     1555   1555  1.32  
LINK        MN    MN M6025                 OE2 GLU M 296     1555   1555  2.61  
LINK        MN    MN M6025                 OE1 GLU M 296     1555   1555  2.39  
LINK        MN    MN M6025                 NE2 HIS M 441     1555   1555  2.48  
LINK        MN    MN M6026                 OD2 ASP M 342     1555   1555  2.35  
LINK        MN    MN M6026                 OD1 ASP M 265     1555   1555  2.45  
LINK        MN    MN M6026                 NE2 HIS M 105     1555   1555  2.27  
LINK        MN    MN M6026                 OD1 ASP M 342     1555   1555  2.26  
LINK         C   ASN N 439                 N   MSE N 440     1555   1555  1.33  
LINK         C   MSE N 440                 N   HIS N 441     1555   1555  1.33  
LINK        MN    MN N6027                 OD2 ASP N 265     1555   1555  2.38  
LINK        MN    MN N6027                 OE1 GLU N 296     1555   1555  2.17  
LINK        MN    MN N6027                 NE2 HIS N 441     1555   1555  2.35  
LINK        MN    MN N6028                 OD2 ASP N 342     1555   1555  2.22  
LINK        MN    MN N6028                 NE2 HIS N 105     1555   1555  2.37  
LINK        MN    MN N6028                 OD1 ASP N 265     1555   1555  2.51  
LINK        MN    MN N6028                 OD1 ASP N 342     1555   1555  2.13  
LINK         C   ASN O 439                 N   MSE O 440     1555   1555  1.32  
LINK         C   MSE O 440                 N   HIS O 441     1555   1555  1.33  
LINK        MN    MN O6029                 NE2 HIS O 441     1555   1555  2.37  
LINK        MN    MN O6029                 OE2 GLU O 296     1555   1555  2.39  
LINK        MN    MN O6029                 OE1 GLU O 296     1555   1555  2.22  
LINK        MN    MN O6029                 O   HOH O6151     1555   1555  2.18  
LINK        MN    MN O6030                 NE2 HIS O 105     1555   1555  2.28  
LINK        MN    MN O6030                 OD1 ASP O 342     1555   1555  2.34  
LINK        MN    MN O6030                 O   HOH O6151     1555   1555  2.61  
LINK        MN    MN O6030                 OD1 ASP O 265     1555   1555  2.56  
LINK        MN    MN O6030                 OD2 ASP O 342     1555   1555  2.63  
LINK         C   ASN P 439                 N   MSE P 440     1555   1555  1.33  
LINK         C   MSE P 440                 N   HIS P 441     1555   1555  1.33  
LINK        MN    MN P6031                 OE2 GLU P 296     1555   1555  2.45  
LINK        MN    MN P6031                 NE2 HIS P 441     1555   1555  2.59  
LINK        MN    MN P6031                 OE1 GLU P 296     1555   1555  2.41  
LINK        MN    MN P6032                 NE2 HIS P 105     1555   1555  2.12  
LINK        MN    MN P6032                 OD1 ASP P 342     1555   1555  2.37  
LINK        MN    MN P6032                 OD1 ASP P 265     1555   1555  2.52  
LINK        MN    MN P6032                 OD2 ASP P 342     1555   1555  2.63  
LINK         C   ASN Q 439                 N   MSE Q 440     1555   1555  1.33  
LINK         C   MSE Q 440                 N   HIS Q 441     1555   1555  1.33  
LINK        MN    MN Q6033                 NE2 HIS Q 441     1555   1555  2.15  
LINK        MN    MN Q6033                 OD2 ASP Q 265     1555   1555  2.64  
LINK        MN    MN Q6033                 OE1 GLU Q 296     1555   1555  2.26  
LINK        MN    MN Q6033                 OE2 GLU Q 296     1555   1555  2.64  
LINK        MN    MN Q6034                 NE2 HIS Q 105     1555   1555  2.40  
LINK        MN    MN Q6034                 OD2 ASP Q 342     1555   1555  2.26  
LINK        MN    MN Q6034                 OD1 ASP Q 265     1555   1555  2.58  
LINK        MN    MN Q6034                 OD1 ASP Q 342     1555   1555  2.11  
LINK         C   ASN R 439                 N   MSE R 440     1555   1555  1.33  
LINK         C   MSE R 440                 N   HIS R 441     1555   1555  1.33  
LINK        MN    MN R6035                 O   HOH R6197     1555   1555  2.31  
LINK        MN    MN R6035                 OE1 GLU R 296     1555   1555  2.35  
LINK        MN    MN R6035                 NE2 HIS R 441     1555   1555  2.52  
LINK        MN    MN R6035                 OE2 GLU R 296     1555   1555  2.31  
LINK        MN    MN R6036                 O   HOH R6197     1555   1555  2.52  
LINK        MN    MN R6036                 OD2 ASP R 342     1555   1555  2.44  
LINK        MN    MN R6036                 NE2 HIS R 105     1555   1555  2.66  
LINK        MN    MN R6036                 OD1 ASP R 265     1555   1555  2.14  
LINK        MN    MN R6036                 OD1 ASP R 342     1555   1555  2.56  
LINK         C   ASN S 439                 N   MSE S 440     1555   1555  1.32  
LINK         C   MSE S 440                 N   HIS S 441     1555   1555  1.33  
LINK        MN    MN S6037                 OE2 GLU S 296     1555   1555  2.72  
LINK        MN    MN S6037                 NE2 HIS S 441     1555   1555  2.41  
LINK        MN    MN S6037                 O   HOH S6121     1555   1555  2.46  
LINK        MN    MN S6037                 OE1 GLU S 296     1555   1555  2.41  
LINK        MN    MN S6038                 OD1 ASP S 342     1555   1555  2.45  
LINK        MN    MN S6038                 OD2 ASP S 342     1555   1555  2.29  
LINK        MN    MN S6038                 OD1 ASP S 265     1555   1555  2.15  
LINK        MN    MN S6038                 NE2 HIS S 105     1555   1555  2.13  
LINK         C   ASN T 439                 N   MSE T 440     1555   1555  1.33  
LINK         C   MSE T 440                 N   HIS T 441     1555   1555  1.33  
LINK        MN    MN T6039                 OE2 GLU T 296     1555   1555  2.62  
LINK        MN    MN T6039                 NE2 HIS T 441     1555   1555  2.44  
LINK        MN    MN T6039                 OE1 GLU T 296     1555   1555  2.34  
LINK        MN    MN T6040                 OD1 ASP T 265     1555   1555  2.44  
LINK        MN    MN T6040                 NE2 HIS T 105     1555   1555  2.40  
LINK        MN    MN T6040                 OD1 ASP T 342     1555   1555  2.20  
LINK        MN    MN T6040                 OD2 ASP T 342     1555   1555  2.26  
LINK         C   ASN U 439                 N   MSE U 440     1555   1555  1.33  
LINK         C   MSE U 440                 N   HIS U 441     1555   1555  1.33  
LINK        MN    MN U6041                 NE2 HIS U 441     1555   1555  2.69  
LINK        MN    MN U6041                 OE1 GLU U 296     1555   1555  2.52  
LINK        MN    MN U6041                 O   HOH U6049     1555   1555  2.40  
LINK        MN    MN U6041                MN    MN U6042     1555   1555  2.75  
LINK        MN    MN U6042                 NE2 HIS U 105     1555   1555  2.36  
LINK        MN    MN U6042                 OD1 ASP U 265     1555   1555  2.50  
LINK        MN    MN U6042                 OD1 ASP U 342     1555   1555  2.19  
LINK        MN    MN U6042                 OD2 ASP U 342     1555   1555  2.38  
LINK         C   ASN V 439                 N   MSE V 440     1555   1555  1.33  
LINK         C   MSE V 440                 N   HIS V 441     1555   1555  1.33  
LINK        MN    MN V6043                 NE2 HIS V 441     1555   1555  2.49  
LINK        MN    MN V6043                 OD2 ASP V 265     1555   1555  2.69  
LINK        MN    MN V6043                 OE1 GLU V 296     1555   1555  2.08  
LINK        MN    MN V6043                 OE2 GLU V 296     1555   1555  2.61  
LINK        MN    MN V6043                MN    MN V6044     1555   1555  2.59  
LINK        MN    MN V6044                 OD1 ASP V 342     1555   1555  2.24  
LINK        MN    MN V6044                 OD2 ASP V 342     1555   1555  2.38  
LINK        MN    MN V6044                 NE2 HIS V 105     1555   1555  2.44  
LINK        MN    MN V6044                 OD1 ASP V 265     1555   1555  2.48  
LINK         C   ASN W 439                 N   MSE W 440     1555   1555  1.33  
LINK         C   MSE W 440                 N   HIS W 441     1555   1555  1.32  
LINK        MN    MN W6045                 OE2 GLU W 296     1555   1555  2.72  
LINK        MN    MN W6045                 OD2 ASP W 265     1555   1555  2.61  
LINK        MN    MN W6045                 OE1 GLU W 296     1555   1555  2.28  
LINK        MN    MN W6045                MN    MN W6046     1555   1555  2.77  
LINK        MN    MN W6045                 NE2 HIS W 441     1555   1555  2.31  
LINK        MN    MN W6045                 O   HOH W6077     1555   1555  2.14  
LINK        MN    MN W6046                 O   HOH W6247     1555   1555  2.56  
LINK        MN    MN W6046                 OD1 ASP W 265     1555   1555  2.47  
LINK        MN    MN W6046                 NE2 HIS W 105     1555   1555  2.70  
LINK        MN    MN W6046                 OD1 ASP W 342     1555   1555  2.26  
LINK        MN    MN W6046                 OD2 ASP W 342     1555   1555  2.25  
LINK         C   ASN X 439                 N   MSE X 440     1555   1555  1.33  
LINK         C   MSE X 440                 N   HIS X 441     1555   1555  1.33  
LINK        MN    MN X6047                 OE2 GLU X 296     1555   1555  2.76  
LINK        MN    MN X6047                 NE2 HIS X 441     1555   1555  2.33  
LINK        MN    MN X6047                 OD2 ASP X 265     1555   1555  2.61  
LINK        MN    MN X6047                 OE1 GLU X 296     1555   1555  2.24  
LINK        MN    MN X6048                 NE2 HIS X 105     1555   1555  2.22  
LINK        MN    MN X6048                 OD1 ASP X 265     1555   1555  2.38  
LINK        MN    MN X6048                 OD2 ASP X 342     1555   1555  2.25  
LINK        MN    MN X6048                 OD1 ASP X 342     1555   1555  2.26  
CISPEP   1 ILE A  206    PRO A  207          0         1.42                     
CISPEP   2 ILE B  206    PRO B  207          0        -7.12                     
CISPEP   3 ILE C  206    PRO C  207          0         3.43                     
CISPEP   4 ILE D  206    PRO D  207          0        -5.25                     
CISPEP   5 ILE E  206    PRO E  207          0        -3.57                     
CISPEP   6 ILE F  206    PRO F  207          0        -0.02                     
CISPEP   7 ILE G  206    PRO G  207          0        -5.11                     
CISPEP   8 ILE H  206    PRO H  207          0         7.54                     
CISPEP   9 ILE I  206    PRO I  207          0        -5.07                     
CISPEP  10 ILE J  206    PRO J  207          0        -7.45                     
CISPEP  11 ILE K  206    PRO K  207          0        -7.51                     
CISPEP  12 ILE L  206    PRO L  207          0        -5.69                     
CISPEP  13 ILE M  206    PRO M  207          0         4.83                     
CISPEP  14 ILE N  206    PRO N  207          0        -0.67                     
CISPEP  15 ILE O  206    PRO O  207          0         8.80                     
CISPEP  16 ILE P  206    PRO P  207          0        -1.02                     
CISPEP  17 ILE Q  206    PRO Q  207          0        -4.50                     
CISPEP  18 ILE R  206    PRO R  207          0         4.24                     
CISPEP  19 ILE S  206    PRO S  207          0        -2.91                     
CISPEP  20 ILE T  206    PRO T  207          0         0.20                     
CISPEP  21 ILE U  206    PRO U  207          0         7.15                     
CISPEP  22 ILE V  206    PRO V  207          0        -6.58                     
CISPEP  23 ILE W  206    PRO W  207          0        -6.10                     
CISPEP  24 ILE X  206    PRO X  207          0       -10.03                     
SITE     1 AC1  6 ASP A 265  GLU A 296  MSE A 440  HIS A 441                    
SITE     2 AC1  6  MN A6002  HOH A6108                                          
SITE     1 AC2  6 HIS A 105  ASP A 265  GLU A 295  GLU A 296                    
SITE     2 AC2  6 ASP A 342   MN A6001                                          
SITE     1 AC3  5 ASP B 265  GLU B 296  MSE B 440  HIS B 441                    
SITE     2 AC3  5  MN B6004                                                     
SITE     1 AC4  6 HIS B 105  ASP B 265  GLU B 295  GLU B 296                    
SITE     2 AC4  6 ASP B 342   MN B6003                                          
SITE     1 AC5  5 ASP C 265  GLU C 296  MSE C 440  HIS C 441                    
SITE     2 AC5  5  MN C6006                                                     
SITE     1 AC6  7 HIS C 105  ASP C 265  GLU C 295  GLU C 296                    
SITE     2 AC6  7 ASP C 342   MN C6005  HOH C6127                               
SITE     1 AC7  5 ASP D 265  GLU D 296  MSE D 440  HIS D 441                    
SITE     2 AC7  5  MN D6008                                                     
SITE     1 AC8  7 HIS D 105  ASP D 265  GLU D 295  GLU D 296                    
SITE     2 AC8  7 ASP D 342   MN D6007  HOH D6026                               
SITE     1 AC9  6 ASP E 265  GLU E 296  MSE E 440  HIS E 441                    
SITE     2 AC9  6  MN E6010  HOH E6203                                          
SITE     1 BC1  6 HIS E 105  ASP E 265  GLU E 295  GLU E 296                    
SITE     2 BC1  6 ASP E 342   MN E6009                                          
SITE     1 BC2  6 ASP F 265  GLU F 296  MSE F 440  HIS F 441                    
SITE     2 BC2  6  MN F6012  HOH F6043                                          
SITE     1 BC3  7 HIS F 105  ASP F 265  GLU F 295  GLU F 296                    
SITE     2 BC3  7 ASP F 342   MN F6011  HOH F6021                               
SITE     1 BC4  6 ASP G 265  GLU G 296  MSE G 440  HIS G 441                    
SITE     2 BC4  6  MN G6014  HOH G6040                                          
SITE     1 BC5  7 HIS G 105  ASP G 265  ASP G 266  GLU G 295                    
SITE     2 BC5  7 GLU G 296  ASP G 342   MN G6013                               
SITE     1 BC6  5 ASP H 265  GLU H 296  MSE H 440  HIS H 441                    
SITE     2 BC6  5  MN H6016                                                     
SITE     1 BC7  5 HIS H 105  ASP H 265  GLU H 296  ASP H 342                    
SITE     2 BC7  5  MN H6015                                                     
SITE     1 BC8  6 ASP I 265  GLU I 296  MSE I 440  HIS I 441                    
SITE     2 BC8  6  MN I6018  HOH I6115                                          
SITE     1 BC9  7 HIS I 105  ASP I 265  GLU I 295  GLU I 296                    
SITE     2 BC9  7 ASP I 342   MN I6017  HOH I6115                               
SITE     1 CC1  6 ASP J 265  GLU J 296  MSE J 440  HIS J 441                    
SITE     2 CC1  6  MN J6020  HOH J6023                                          
SITE     1 CC2  5 HIS J 105  ASP J 265  GLU J 296  ASP J 342                    
SITE     2 CC2  5  MN J6019                                                     
SITE     1 CC3  5 ASP K 265  GLU K 296  MSE K 440  HIS K 441                    
SITE     2 CC3  5  MN K6022                                                     
SITE     1 CC4  6 HIS K 105  ASP K 265  GLU K 295  GLU K 296                    
SITE     2 CC4  6 ASP K 342   MN K6021                                          
SITE     1 CC5  6 ASP L 265  GLU L 296  MSE L 440  HIS L 441                    
SITE     2 CC5  6  MN L6024  HOH L6116                                          
SITE     1 CC6  6 HIS L 105  ASP L 265  GLU L 295  GLU L 296                    
SITE     2 CC6  6 ASP L 342   MN L6023                                          
SITE     1 CC7  6 ASP M 265  GLU M 296  MSE M 440  HIS M 441                    
SITE     2 CC7  6  MN M6026  HOH M6219                                          
SITE     1 CC8  6 HIS M 105  ASP M 265  GLU M 295  GLU M 296                    
SITE     2 CC8  6 ASP M 342   MN M6025                                          
SITE     1 CC9  5 ASP N 265  GLU N 296  MSE N 440  HIS N 441                    
SITE     2 CC9  5  MN N6028                                                     
SITE     1 DC1  6 HIS N 105  ASP N 265  GLU N 295  GLU N 296                    
SITE     2 DC1  6 ASP N 342   MN N6027                                          
SITE     1 DC2  6 ASP O 265  GLU O 296  MSE O 440  HIS O 441                    
SITE     2 DC2  6  MN O6030  HOH O6151                                          
SITE     1 DC3  7 HIS O 105  ASP O 265  GLU O 295  GLU O 296                    
SITE     2 DC3  7 ASP O 342   MN O6029  HOH O6151                               
SITE     1 DC4  6 ASP P 265  GLU P 296  MSE P 440  HIS P 441                    
SITE     2 DC4  6  MN P6032  HOH P6072                                          
SITE     1 DC5  6 HIS P 105  ASP P 265  GLU P 295  GLU P 296                    
SITE     2 DC5  6 ASP P 342   MN P6031                                          
SITE     1 DC6  6 ASP Q 265  GLU Q 296  MSE Q 440  HIS Q 441                    
SITE     2 DC6  6  MN Q6034  HOH Q6056                                          
SITE     1 DC7  7 HIS Q 105  ASP Q 265  GLU Q 295  GLU Q 296                    
SITE     2 DC7  7 ASP Q 342   MN Q6033  HOH Q6056                               
SITE     1 DC8  6 ASP R 265  GLU R 296  MSE R 440  HIS R 441                    
SITE     2 DC8  6  MN R6036  HOH R6197                                          
SITE     1 DC9  6 HIS R 105  ASP R 265  GLU R 296  ASP R 342                    
SITE     2 DC9  6  MN R6035  HOH R6197                                          
SITE     1 EC1  6 ASP S 265  GLU S 296  MSE S 440  HIS S 441                    
SITE     2 EC1  6  MN S6038  HOH S6121                                          
SITE     1 EC2  6 HIS S 105  ASP S 265  GLU S 295  GLU S 296                    
SITE     2 EC2  6 ASP S 342   MN S6037                                          
SITE     1 EC3  5 ASP T 265  GLU T 296  MSE T 440  HIS T 441                    
SITE     2 EC3  5  MN T6040                                                     
SITE     1 EC4  6 HIS T 105  ASP T 265  GLU T 295  GLU T 296                    
SITE     2 EC4  6 ASP T 342   MN T6039                                          
SITE     1 EC5  7 ASP U 265  GLU U 296  MSE U 440  HIS U 441                    
SITE     2 EC5  7  MN U6042  HOH U6049  HOH U6087                               
SITE     1 EC6  6 HIS U 105  ASP U 265  GLU U 295  GLU U 296                    
SITE     2 EC6  6 ASP U 342   MN U6041                                          
SITE     1 EC7  7 ASP V 265  GLU V 296  MSE V 440  HIS V 441                    
SITE     2 EC7  7  MN V6044  HOH V6121  HOH V6264                               
SITE     1 EC8  7 HIS V 105  ASP V 265  GLU V 295  GLU V 296                    
SITE     2 EC8  7 ASP V 342   MN V6043  HOH V6264                               
SITE     1 EC9  6 ASP W 265  GLU W 296  MSE W 440  HIS W 441                    
SITE     2 EC9  6  MN W6046  HOH W6077                                          
SITE     1 FC1  6 HIS W 105  ASP W 265  GLU W 296  ASP W 342                    
SITE     2 FC1  6  MN W6045  HOH W6247                                          
SITE     1 FC2  5 ASP X 265  GLU X 296  MSE X 440  HIS X 441                    
SITE     2 FC2  5  MN X6048                                                     
SITE     1 FC3  6 HIS X 105  ASP X 265  GLU X 295  GLU X 296                    
SITE     2 FC3  6 ASP X 342   MN X6047                                          
CRYST1  121.708  129.680  222.728  89.88  90.00 116.68 P 1          24          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.008216  0.004129 -0.000010        0.00000                         
SCALE2      0.000000  0.008630 -0.000021        0.00000                         
SCALE3      0.000000  0.000000  0.004490        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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