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Database: PDB
Entry: 2WVW
LinkDB: 2WVW
Original site: 2WVW 
HEADER    PHOTOSYNTHESIS                          20-OCT-09   2WVW              
TITLE     CRYO-EM STRUCTURE OF THE RBCL-RBCX COMPLEX                            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: RBCX PROTEIN;                                              
COMPND   3 CHAIN: I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X;               
COMPND   4 SYNONYM: RUBISCO ASSEMBLY CHAPERONE;                                 
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN;             
COMPND   8 CHAIN: A, B, C, D, E, F, G, H;                                       
COMPND   9 SYNONYM: RBCL, RUBISCO LARGE SUBUNIT;                                
COMPND  10 EC: 4.1.1.39;                                                        
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ANABAENA SP. CA;                                
SOURCE   3 ORGANISM_TAXID: 52271;                                               
SOURCE   4 ATCC: 33047;                                                         
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PET28B;                                   
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: SYNECHOCOCCUS ELONGATUS;                        
SOURCE  11 ORGANISM_TAXID: 269084;                                              
SOURCE  12 STRAIN: PCC 6301;                                                    
SOURCE  13 ATCC: 27144;                                                         
SOURCE  14 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE  16 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE  17 EXPRESSION_SYSTEM_PLASMID: PET11A                                    
KEYWDS    COMPLEX ASSEMBLY, PHOTORESPIRATION, PHOTOSYNTHESIS, DISULFIDE BOND,   
KEYWDS   2 CARBON FIXATION, LYASE, CHAPERONE, CALVIN CYCLE, CARBON DIOXIDE      
KEYWDS   3 FIXATION, MONOOXYGENASE, METAL-BINDING, OXIDOREDUCTASE               
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    C.LIU,A.L.YOUNG,A.STARLING-WINDHOF,A.BRACHER,S.SASCHENBRECKER,        
AUTHOR   2 B.V.RAO,K.V.RAO,O.BERNINGHAUSEN,T.MIELKE,F.U.HARTL,R.BECKMANN,       
AUTHOR   3 M.HAYER-HARTL                                                        
REVDAT   3   06-JUN-12 2WVW    1       JRNL                                     
REVDAT   2   27-JUL-11 2WVW    1       REMARK VERSN  MASTER                     
REVDAT   1   19-JAN-10 2WVW    0                                                
JRNL        AUTH   C.LIU,A.L.YOUNG,A.STARLING-WINDHOF,A.BRACHER,                
JRNL        AUTH 2 S.SASCHENBRECKER,B.V.RAO,K.V.RAO,O.BERNINGHAUSEN,T.MIELKE,   
JRNL        AUTH 3 F.U.HARTL,R.BECKMANN,M.HAYER-HARTL                           
JRNL        TITL   COUPLED CHAPERONE ACTION IN FOLDING AND ASSEMBLY OF          
JRNL        TITL 2 HEXADECAMERIC RUBISCO                                        
JRNL        REF    NATURE                        V. 463   197 2010              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   20075914                                                     
JRNL        DOI    10.1038/NATURE08651                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    9.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : EMAN1                                     
REMARK   3   RECONSTRUCTION SCHEMA  : STANDARD EMAN REFINE PROCEDURE            
REMARK   3                                                                      
REMARK   3  EM MAP-MODEL FITTING AND REFINEMENT                                 
REMARK   3   PDB ENTRY                    : 3HYB                                
REMARK   3   REFINEMENT SPACE             : RECIPROCAL                          
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3  FITTING PROCEDURE : MANUAL                                          
REMARK   3                                                                      
REMARK   3  EM IMAGE RECONSTRUCTION STATISTICS                                  
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 1.63                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : 1.63                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 9                              
REMARK   3   NUMBER OF PARTICLES               : 11104                          
REMARK   3   CTF CORRECTION METHOD             : EACH PARTICLE                  
REMARK   3                                                                      
REMARK   3  EM RECONSTRUCTION MAGNIFICATION CALIBRATION : NULL                  
REMARK   3                                                                      
REMARK   3  OTHER DETAILS: NULL                                                 
REMARK   4                                                                      
REMARK   4 2WVW COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 21-OCT-09.                  
REMARK 100 THE PDBE ID CODE IS EBI-41444.                                       
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE (CRYO EM)            
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : ASYMMETRIC                        
REMARK 245   NAME OF SAMPLE                 : RBCL8-X8 RUBISCO                  
REMARK 245                                    ASSEMBLY INTERMEDIATE             
REMARK 245                                    CONTAINING 8 COPIES OF            
REMARK 245                                    THE LARGE RUBISCO SUBUNIT         
REMARK 245                                    RBCL AND EIGHT COPIES OF          
REMARK 245                                    THE DIMERIC ASSEMBLY              
REMARK 245                                    CHAPERONE RBCX2.                  
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : QUANTIFOIL GRIDS (3/3)            
REMARK 245                                    WITH 2 NM CARBON ON TOP           
REMARK 245   SAMPLE VITRIFICATION DETAILS   : VITROBOT USED, LIQUID             
REMARK 245                                    ETHANE                            
REMARK 245   SAMPLE BUFFER                  : 20 MM TRIS-HCL, PH 8.7            
REMARK 245   PH                             : 8.7                               
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA AQUISITION                                                      
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 56                             
REMARK 245   TEMPERATURE (KELVIN)              : 85                             
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI F30                 
REMARK 245   DETECTOR TYPE                     : KODAK SO163                    
REMARK 245   MINIMUM DEFOCUS (NM)              : 1000                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3100                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : 0                              
REMARK 245   NOMINAL CS                        : 2.26                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 20                             
REMARK 245   ILLUMINATION MODE                 : FLOODBEAM                      
REMARK 245   NOMINAL MAGNIFICATION             : 39000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 38900                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE             
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS                                            
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY.  THE REMARK MAY ALSO PROVIDE INFORMATION ON              
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 GENERATING THE BIOMOLECULE                                           
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24MERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 24MERIC                    
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I,            
REMARK 350                    AND CHAINS: J, K, L, M, N, O, P, Q, R,            
REMARK 350                    AND CHAINS: S, T, U, V, W, X                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     4                                                      
REMARK 465     PRO A     5                                                      
REMARK 465     LYS A     6                                                      
REMARK 465     THR A     7                                                      
REMARK 465     GLN A     8                                                      
REMARK 465     MET B     4                                                      
REMARK 465     PRO B     5                                                      
REMARK 465     LYS B     6                                                      
REMARK 465     THR B     7                                                      
REMARK 465     GLN B     8                                                      
REMARK 465     MET C     4                                                      
REMARK 465     PRO C     5                                                      
REMARK 465     LYS C     6                                                      
REMARK 465     THR C     7                                                      
REMARK 465     GLN C     8                                                      
REMARK 465     MET D     4                                                      
REMARK 465     PRO D     5                                                      
REMARK 465     LYS D     6                                                      
REMARK 465     THR D     7                                                      
REMARK 465     GLN D     8                                                      
REMARK 465     MET E     4                                                      
REMARK 465     PRO E     5                                                      
REMARK 465     LYS E     6                                                      
REMARK 465     THR E     7                                                      
REMARK 465     GLN E     8                                                      
REMARK 465     MET F     4                                                      
REMARK 465     PRO F     5                                                      
REMARK 465     LYS F     6                                                      
REMARK 465     THR F     7                                                      
REMARK 465     GLN F     8                                                      
REMARK 465     MET G     4                                                      
REMARK 465     PRO G     5                                                      
REMARK 465     LYS G     6                                                      
REMARK 465     THR G     7                                                      
REMARK 465     GLN G     8                                                      
REMARK 465     MET H     4                                                      
REMARK 465     PRO H     5                                                      
REMARK 465     LYS H     6                                                      
REMARK 465     THR H     7                                                      
REMARK 465     GLN H     8                                                      
REMARK 465     MET I   -19                                                      
REMARK 465     GLY I   -18                                                      
REMARK 465     SER I   -17                                                      
REMARK 465     SER I   -16                                                      
REMARK 465     HIS I   -15                                                      
REMARK 465     HIS I   -14                                                      
REMARK 465     HIS I   -13                                                      
REMARK 465     HIS I   -12                                                      
REMARK 465     HIS I   -11                                                      
REMARK 465     HIS I   -10                                                      
REMARK 465     SER I    -9                                                      
REMARK 465     SER I    -8                                                      
REMARK 465     GLY I    -7                                                      
REMARK 465     LEU I    -6                                                      
REMARK 465     VAL I    -5                                                      
REMARK 465     PRO I    -4                                                      
REMARK 465     ARG I    -3                                                      
REMARK 465     GLY I    -2                                                      
REMARK 465     SER I    -1                                                      
REMARK 465     HIS I     0                                                      
REMARK 465     GLU I   106                                                      
REMARK 465     ARG I   107                                                      
REMARK 465     MET I   108                                                      
REMARK 465     THR I   109                                                      
REMARK 465     GLN I   110                                                      
REMARK 465     VAL I   111                                                      
REMARK 465     SER I   112                                                      
REMARK 465     LEU I   113                                                      
REMARK 465     SER I   114                                                      
REMARK 465     HIS I   115                                                      
REMARK 465     PRO I   116                                                      
REMARK 465     SER I   117                                                      
REMARK 465     PRO I   118                                                      
REMARK 465     GLU I   119                                                      
REMARK 465     SER I   120                                                      
REMARK 465     GLU I   121                                                      
REMARK 465     GLN I   122                                                      
REMARK 465     GLN I   123                                                      
REMARK 465     GLN I   124                                                      
REMARK 465     PHE I   125                                                      
REMARK 465     SER I   126                                                      
REMARK 465     ASP I   127                                                      
REMARK 465     PRO I   128                                                      
REMARK 465     ASP I   129                                                      
REMARK 465     TRP I   130                                                      
REMARK 465     ASP I   131                                                      
REMARK 465     ASN I   132                                                      
REMARK 465     LEU I   133                                                      
REMARK 465     ALA I   134                                                      
REMARK 465     SER I   135                                                      
REMARK 465     MET J   -19                                                      
REMARK 465     GLY J   -18                                                      
REMARK 465     SER J   -17                                                      
REMARK 465     SER J   -16                                                      
REMARK 465     HIS J   -15                                                      
REMARK 465     HIS J   -14                                                      
REMARK 465     HIS J   -13                                                      
REMARK 465     HIS J   -12                                                      
REMARK 465     HIS J   -11                                                      
REMARK 465     HIS J   -10                                                      
REMARK 465     SER J    -9                                                      
REMARK 465     SER J    -8                                                      
REMARK 465     GLY J    -7                                                      
REMARK 465     LEU J    -6                                                      
REMARK 465     VAL J    -5                                                      
REMARK 465     PRO J    -4                                                      
REMARK 465     ARG J    -3                                                      
REMARK 465     GLY J    -2                                                      
REMARK 465     SER J    -1                                                      
REMARK 465     HIS J     0                                                      
REMARK 465     GLU J   106                                                      
REMARK 465     ARG J   107                                                      
REMARK 465     MET J   108                                                      
REMARK 465     THR J   109                                                      
REMARK 465     GLN J   110                                                      
REMARK 465     VAL J   111                                                      
REMARK 465     SER J   112                                                      
REMARK 465     LEU J   113                                                      
REMARK 465     SER J   114                                                      
REMARK 465     HIS J   115                                                      
REMARK 465     PRO J   116                                                      
REMARK 465     SER J   117                                                      
REMARK 465     PRO J   118                                                      
REMARK 465     GLU J   119                                                      
REMARK 465     SER J   120                                                      
REMARK 465     GLU J   121                                                      
REMARK 465     GLN J   122                                                      
REMARK 465     GLN J   123                                                      
REMARK 465     GLN J   124                                                      
REMARK 465     PHE J   125                                                      
REMARK 465     SER J   126                                                      
REMARK 465     ASP J   127                                                      
REMARK 465     PRO J   128                                                      
REMARK 465     ASP J   129                                                      
REMARK 465     TRP J   130                                                      
REMARK 465     ASP J   131                                                      
REMARK 465     ASN J   132                                                      
REMARK 465     LEU J   133                                                      
REMARK 465     ALA J   134                                                      
REMARK 465     SER J   135                                                      
REMARK 465     MET K   -19                                                      
REMARK 465     GLY K   -18                                                      
REMARK 465     SER K   -17                                                      
REMARK 465     SER K   -16                                                      
REMARK 465     HIS K   -15                                                      
REMARK 465     HIS K   -14                                                      
REMARK 465     HIS K   -13                                                      
REMARK 465     HIS K   -12                                                      
REMARK 465     HIS K   -11                                                      
REMARK 465     HIS K   -10                                                      
REMARK 465     SER K    -9                                                      
REMARK 465     SER K    -8                                                      
REMARK 465     GLY K    -7                                                      
REMARK 465     LEU K    -6                                                      
REMARK 465     VAL K    -5                                                      
REMARK 465     PRO K    -4                                                      
REMARK 465     ARG K    -3                                                      
REMARK 465     GLY K    -2                                                      
REMARK 465     SER K    -1                                                      
REMARK 465     HIS K     0                                                      
REMARK 465     GLU K   106                                                      
REMARK 465     ARG K   107                                                      
REMARK 465     MET K   108                                                      
REMARK 465     THR K   109                                                      
REMARK 465     GLN K   110                                                      
REMARK 465     VAL K   111                                                      
REMARK 465     SER K   112                                                      
REMARK 465     LEU K   113                                                      
REMARK 465     SER K   114                                                      
REMARK 465     HIS K   115                                                      
REMARK 465     PRO K   116                                                      
REMARK 465     SER K   117                                                      
REMARK 465     PRO K   118                                                      
REMARK 465     GLU K   119                                                      
REMARK 465     SER K   120                                                      
REMARK 465     GLU K   121                                                      
REMARK 465     GLN K   122                                                      
REMARK 465     GLN K   123                                                      
REMARK 465     GLN K   124                                                      
REMARK 465     PHE K   125                                                      
REMARK 465     SER K   126                                                      
REMARK 465     ASP K   127                                                      
REMARK 465     PRO K   128                                                      
REMARK 465     ASP K   129                                                      
REMARK 465     TRP K   130                                                      
REMARK 465     ASP K   131                                                      
REMARK 465     ASN K   132                                                      
REMARK 465     LEU K   133                                                      
REMARK 465     ALA K   134                                                      
REMARK 465     SER K   135                                                      
REMARK 465     MET L   -19                                                      
REMARK 465     GLY L   -18                                                      
REMARK 465     SER L   -17                                                      
REMARK 465     SER L   -16                                                      
REMARK 465     HIS L   -15                                                      
REMARK 465     HIS L   -14                                                      
REMARK 465     HIS L   -13                                                      
REMARK 465     HIS L   -12                                                      
REMARK 465     HIS L   -11                                                      
REMARK 465     HIS L   -10                                                      
REMARK 465     SER L    -9                                                      
REMARK 465     SER L    -8                                                      
REMARK 465     GLY L    -7                                                      
REMARK 465     LEU L    -6                                                      
REMARK 465     VAL L    -5                                                      
REMARK 465     PRO L    -4                                                      
REMARK 465     ARG L    -3                                                      
REMARK 465     GLY L    -2                                                      
REMARK 465     SER L    -1                                                      
REMARK 465     HIS L     0                                                      
REMARK 465     GLU L   106                                                      
REMARK 465     ARG L   107                                                      
REMARK 465     MET L   108                                                      
REMARK 465     THR L   109                                                      
REMARK 465     GLN L   110                                                      
REMARK 465     VAL L   111                                                      
REMARK 465     SER L   112                                                      
REMARK 465     LEU L   113                                                      
REMARK 465     SER L   114                                                      
REMARK 465     HIS L   115                                                      
REMARK 465     PRO L   116                                                      
REMARK 465     SER L   117                                                      
REMARK 465     PRO L   118                                                      
REMARK 465     GLU L   119                                                      
REMARK 465     SER L   120                                                      
REMARK 465     GLU L   121                                                      
REMARK 465     GLN L   122                                                      
REMARK 465     GLN L   123                                                      
REMARK 465     GLN L   124                                                      
REMARK 465     PHE L   125                                                      
REMARK 465     SER L   126                                                      
REMARK 465     ASP L   127                                                      
REMARK 465     PRO L   128                                                      
REMARK 465     ASP L   129                                                      
REMARK 465     TRP L   130                                                      
REMARK 465     ASP L   131                                                      
REMARK 465     ASN L   132                                                      
REMARK 465     LEU L   133                                                      
REMARK 465     ALA L   134                                                      
REMARK 465     SER L   135                                                      
REMARK 465     MET M   -19                                                      
REMARK 465     GLY M   -18                                                      
REMARK 465     SER M   -17                                                      
REMARK 465     SER M   -16                                                      
REMARK 465     HIS M   -15                                                      
REMARK 465     HIS M   -14                                                      
REMARK 465     HIS M   -13                                                      
REMARK 465     HIS M   -12                                                      
REMARK 465     HIS M   -11                                                      
REMARK 465     HIS M   -10                                                      
REMARK 465     SER M    -9                                                      
REMARK 465     SER M    -8                                                      
REMARK 465     GLY M    -7                                                      
REMARK 465     LEU M    -6                                                      
REMARK 465     VAL M    -5                                                      
REMARK 465     PRO M    -4                                                      
REMARK 465     ARG M    -3                                                      
REMARK 465     GLY M    -2                                                      
REMARK 465     SER M    -1                                                      
REMARK 465     HIS M     0                                                      
REMARK 465     GLU M   106                                                      
REMARK 465     ARG M   107                                                      
REMARK 465     MET M   108                                                      
REMARK 465     THR M   109                                                      
REMARK 465     GLN M   110                                                      
REMARK 465     VAL M   111                                                      
REMARK 465     SER M   112                                                      
REMARK 465     LEU M   113                                                      
REMARK 465     SER M   114                                                      
REMARK 465     HIS M   115                                                      
REMARK 465     PRO M   116                                                      
REMARK 465     SER M   117                                                      
REMARK 465     PRO M   118                                                      
REMARK 465     GLU M   119                                                      
REMARK 465     SER M   120                                                      
REMARK 465     GLU M   121                                                      
REMARK 465     GLN M   122                                                      
REMARK 465     GLN M   123                                                      
REMARK 465     GLN M   124                                                      
REMARK 465     PHE M   125                                                      
REMARK 465     SER M   126                                                      
REMARK 465     ASP M   127                                                      
REMARK 465     PRO M   128                                                      
REMARK 465     ASP M   129                                                      
REMARK 465     TRP M   130                                                      
REMARK 465     ASP M   131                                                      
REMARK 465     ASN M   132                                                      
REMARK 465     LEU M   133                                                      
REMARK 465     ALA M   134                                                      
REMARK 465     SER M   135                                                      
REMARK 465     MET N   -19                                                      
REMARK 465     GLY N   -18                                                      
REMARK 465     SER N   -17                                                      
REMARK 465     SER N   -16                                                      
REMARK 465     HIS N   -15                                                      
REMARK 465     HIS N   -14                                                      
REMARK 465     HIS N   -13                                                      
REMARK 465     HIS N   -12                                                      
REMARK 465     HIS N   -11                                                      
REMARK 465     HIS N   -10                                                      
REMARK 465     SER N    -9                                                      
REMARK 465     SER N    -8                                                      
REMARK 465     GLY N    -7                                                      
REMARK 465     LEU N    -6                                                      
REMARK 465     VAL N    -5                                                      
REMARK 465     PRO N    -4                                                      
REMARK 465     ARG N    -3                                                      
REMARK 465     GLY N    -2                                                      
REMARK 465     SER N    -1                                                      
REMARK 465     HIS N     0                                                      
REMARK 465     GLU N   106                                                      
REMARK 465     ARG N   107                                                      
REMARK 465     MET N   108                                                      
REMARK 465     THR N   109                                                      
REMARK 465     GLN N   110                                                      
REMARK 465     VAL N   111                                                      
REMARK 465     SER N   112                                                      
REMARK 465     LEU N   113                                                      
REMARK 465     SER N   114                                                      
REMARK 465     HIS N   115                                                      
REMARK 465     PRO N   116                                                      
REMARK 465     SER N   117                                                      
REMARK 465     PRO N   118                                                      
REMARK 465     GLU N   119                                                      
REMARK 465     SER N   120                                                      
REMARK 465     GLU N   121                                                      
REMARK 465     GLN N   122                                                      
REMARK 465     GLN N   123                                                      
REMARK 465     GLN N   124                                                      
REMARK 465     PHE N   125                                                      
REMARK 465     SER N   126                                                      
REMARK 465     ASP N   127                                                      
REMARK 465     PRO N   128                                                      
REMARK 465     ASP N   129                                                      
REMARK 465     TRP N   130                                                      
REMARK 465     ASP N   131                                                      
REMARK 465     ASN N   132                                                      
REMARK 465     LEU N   133                                                      
REMARK 465     ALA N   134                                                      
REMARK 465     SER N   135                                                      
REMARK 465     MET O   -19                                                      
REMARK 465     GLY O   -18                                                      
REMARK 465     SER O   -17                                                      
REMARK 465     SER O   -16                                                      
REMARK 465     HIS O   -15                                                      
REMARK 465     HIS O   -14                                                      
REMARK 465     HIS O   -13                                                      
REMARK 465     HIS O   -12                                                      
REMARK 465     HIS O   -11                                                      
REMARK 465     HIS O   -10                                                      
REMARK 465     SER O    -9                                                      
REMARK 465     SER O    -8                                                      
REMARK 465     GLY O    -7                                                      
REMARK 465     LEU O    -6                                                      
REMARK 465     VAL O    -5                                                      
REMARK 465     PRO O    -4                                                      
REMARK 465     ARG O    -3                                                      
REMARK 465     GLY O    -2                                                      
REMARK 465     SER O    -1                                                      
REMARK 465     HIS O     0                                                      
REMARK 465     GLU O   106                                                      
REMARK 465     ARG O   107                                                      
REMARK 465     MET O   108                                                      
REMARK 465     THR O   109                                                      
REMARK 465     GLN O   110                                                      
REMARK 465     VAL O   111                                                      
REMARK 465     SER O   112                                                      
REMARK 465     LEU O   113                                                      
REMARK 465     SER O   114                                                      
REMARK 465     HIS O   115                                                      
REMARK 465     PRO O   116                                                      
REMARK 465     SER O   117                                                      
REMARK 465     PRO O   118                                                      
REMARK 465     GLU O   119                                                      
REMARK 465     SER O   120                                                      
REMARK 465     GLU O   121                                                      
REMARK 465     GLN O   122                                                      
REMARK 465     GLN O   123                                                      
REMARK 465     GLN O   124                                                      
REMARK 465     PHE O   125                                                      
REMARK 465     SER O   126                                                      
REMARK 465     ASP O   127                                                      
REMARK 465     PRO O   128                                                      
REMARK 465     ASP O   129                                                      
REMARK 465     TRP O   130                                                      
REMARK 465     ASP O   131                                                      
REMARK 465     ASN O   132                                                      
REMARK 465     LEU O   133                                                      
REMARK 465     ALA O   134                                                      
REMARK 465     SER O   135                                                      
REMARK 465     MET P   -19                                                      
REMARK 465     GLY P   -18                                                      
REMARK 465     SER P   -17                                                      
REMARK 465     SER P   -16                                                      
REMARK 465     HIS P   -15                                                      
REMARK 465     HIS P   -14                                                      
REMARK 465     HIS P   -13                                                      
REMARK 465     HIS P   -12                                                      
REMARK 465     HIS P   -11                                                      
REMARK 465     HIS P   -10                                                      
REMARK 465     SER P    -9                                                      
REMARK 465     SER P    -8                                                      
REMARK 465     GLY P    -7                                                      
REMARK 465     LEU P    -6                                                      
REMARK 465     VAL P    -5                                                      
REMARK 465     PRO P    -4                                                      
REMARK 465     ARG P    -3                                                      
REMARK 465     GLY P    -2                                                      
REMARK 465     SER P    -1                                                      
REMARK 465     HIS P     0                                                      
REMARK 465     GLU P   106                                                      
REMARK 465     ARG P   107                                                      
REMARK 465     MET P   108                                                      
REMARK 465     THR P   109                                                      
REMARK 465     GLN P   110                                                      
REMARK 465     VAL P   111                                                      
REMARK 465     SER P   112                                                      
REMARK 465     LEU P   113                                                      
REMARK 465     SER P   114                                                      
REMARK 465     HIS P   115                                                      
REMARK 465     PRO P   116                                                      
REMARK 465     SER P   117                                                      
REMARK 465     PRO P   118                                                      
REMARK 465     GLU P   119                                                      
REMARK 465     SER P   120                                                      
REMARK 465     GLU P   121                                                      
REMARK 465     GLN P   122                                                      
REMARK 465     GLN P   123                                                      
REMARK 465     GLN P   124                                                      
REMARK 465     PHE P   125                                                      
REMARK 465     SER P   126                                                      
REMARK 465     ASP P   127                                                      
REMARK 465     PRO P   128                                                      
REMARK 465     ASP P   129                                                      
REMARK 465     TRP P   130                                                      
REMARK 465     ASP P   131                                                      
REMARK 465     ASN P   132                                                      
REMARK 465     LEU P   133                                                      
REMARK 465     ALA P   134                                                      
REMARK 465     SER P   135                                                      
REMARK 465     MET Q   -19                                                      
REMARK 465     GLY Q   -18                                                      
REMARK 465     SER Q   -17                                                      
REMARK 465     SER Q   -16                                                      
REMARK 465     HIS Q   -15                                                      
REMARK 465     HIS Q   -14                                                      
REMARK 465     HIS Q   -13                                                      
REMARK 465     HIS Q   -12                                                      
REMARK 465     HIS Q   -11                                                      
REMARK 465     HIS Q   -10                                                      
REMARK 465     SER Q    -9                                                      
REMARK 465     SER Q    -8                                                      
REMARK 465     GLY Q    -7                                                      
REMARK 465     LEU Q    -6                                                      
REMARK 465     VAL Q    -5                                                      
REMARK 465     PRO Q    -4                                                      
REMARK 465     ARG Q    -3                                                      
REMARK 465     GLY Q    -2                                                      
REMARK 465     SER Q    -1                                                      
REMARK 465     HIS Q     0                                                      
REMARK 465     GLU Q   106                                                      
REMARK 465     ARG Q   107                                                      
REMARK 465     MET Q   108                                                      
REMARK 465     THR Q   109                                                      
REMARK 465     GLN Q   110                                                      
REMARK 465     VAL Q   111                                                      
REMARK 465     SER Q   112                                                      
REMARK 465     LEU Q   113                                                      
REMARK 465     SER Q   114                                                      
REMARK 465     HIS Q   115                                                      
REMARK 465     PRO Q   116                                                      
REMARK 465     SER Q   117                                                      
REMARK 465     PRO Q   118                                                      
REMARK 465     GLU Q   119                                                      
REMARK 465     SER Q   120                                                      
REMARK 465     GLU Q   121                                                      
REMARK 465     GLN Q   122                                                      
REMARK 465     GLN Q   123                                                      
REMARK 465     GLN Q   124                                                      
REMARK 465     PHE Q   125                                                      
REMARK 465     SER Q   126                                                      
REMARK 465     ASP Q   127                                                      
REMARK 465     PRO Q   128                                                      
REMARK 465     ASP Q   129                                                      
REMARK 465     TRP Q   130                                                      
REMARK 465     ASP Q   131                                                      
REMARK 465     ASN Q   132                                                      
REMARK 465     LEU Q   133                                                      
REMARK 465     ALA Q   134                                                      
REMARK 465     SER Q   135                                                      
REMARK 465     MET R   -19                                                      
REMARK 465     GLY R   -18                                                      
REMARK 465     SER R   -17                                                      
REMARK 465     SER R   -16                                                      
REMARK 465     HIS R   -15                                                      
REMARK 465     HIS R   -14                                                      
REMARK 465     HIS R   -13                                                      
REMARK 465     HIS R   -12                                                      
REMARK 465     HIS R   -11                                                      
REMARK 465     HIS R   -10                                                      
REMARK 465     SER R    -9                                                      
REMARK 465     SER R    -8                                                      
REMARK 465     GLY R    -7                                                      
REMARK 465     LEU R    -6                                                      
REMARK 465     VAL R    -5                                                      
REMARK 465     PRO R    -4                                                      
REMARK 465     ARG R    -3                                                      
REMARK 465     GLY R    -2                                                      
REMARK 465     SER R    -1                                                      
REMARK 465     HIS R     0                                                      
REMARK 465     GLU R   106                                                      
REMARK 465     ARG R   107                                                      
REMARK 465     MET R   108                                                      
REMARK 465     THR R   109                                                      
REMARK 465     GLN R   110                                                      
REMARK 465     VAL R   111                                                      
REMARK 465     SER R   112                                                      
REMARK 465     LEU R   113                                                      
REMARK 465     SER R   114                                                      
REMARK 465     HIS R   115                                                      
REMARK 465     PRO R   116                                                      
REMARK 465     SER R   117                                                      
REMARK 465     PRO R   118                                                      
REMARK 465     GLU R   119                                                      
REMARK 465     SER R   120                                                      
REMARK 465     GLU R   121                                                      
REMARK 465     GLN R   122                                                      
REMARK 465     GLN R   123                                                      
REMARK 465     GLN R   124                                                      
REMARK 465     PHE R   125                                                      
REMARK 465     SER R   126                                                      
REMARK 465     ASP R   127                                                      
REMARK 465     PRO R   128                                                      
REMARK 465     ASP R   129                                                      
REMARK 465     TRP R   130                                                      
REMARK 465     ASP R   131                                                      
REMARK 465     ASN R   132                                                      
REMARK 465     LEU R   133                                                      
REMARK 465     ALA R   134                                                      
REMARK 465     SER R   135                                                      
REMARK 465     MET S   -19                                                      
REMARK 465     GLY S   -18                                                      
REMARK 465     SER S   -17                                                      
REMARK 465     SER S   -16                                                      
REMARK 465     HIS S   -15                                                      
REMARK 465     HIS S   -14                                                      
REMARK 465     HIS S   -13                                                      
REMARK 465     HIS S   -12                                                      
REMARK 465     HIS S   -11                                                      
REMARK 465     HIS S   -10                                                      
REMARK 465     SER S    -9                                                      
REMARK 465     SER S    -8                                                      
REMARK 465     GLY S    -7                                                      
REMARK 465     LEU S    -6                                                      
REMARK 465     VAL S    -5                                                      
REMARK 465     PRO S    -4                                                      
REMARK 465     ARG S    -3                                                      
REMARK 465     GLY S    -2                                                      
REMARK 465     SER S    -1                                                      
REMARK 465     HIS S     0                                                      
REMARK 465     GLU S   106                                                      
REMARK 465     ARG S   107                                                      
REMARK 465     MET S   108                                                      
REMARK 465     THR S   109                                                      
REMARK 465     GLN S   110                                                      
REMARK 465     VAL S   111                                                      
REMARK 465     SER S   112                                                      
REMARK 465     LEU S   113                                                      
REMARK 465     SER S   114                                                      
REMARK 465     HIS S   115                                                      
REMARK 465     PRO S   116                                                      
REMARK 465     SER S   117                                                      
REMARK 465     PRO S   118                                                      
REMARK 465     GLU S   119                                                      
REMARK 465     SER S   120                                                      
REMARK 465     GLU S   121                                                      
REMARK 465     GLN S   122                                                      
REMARK 465     GLN S   123                                                      
REMARK 465     GLN S   124                                                      
REMARK 465     PHE S   125                                                      
REMARK 465     SER S   126                                                      
REMARK 465     ASP S   127                                                      
REMARK 465     PRO S   128                                                      
REMARK 465     ASP S   129                                                      
REMARK 465     TRP S   130                                                      
REMARK 465     ASP S   131                                                      
REMARK 465     ASN S   132                                                      
REMARK 465     LEU S   133                                                      
REMARK 465     ALA S   134                                                      
REMARK 465     SER S   135                                                      
REMARK 465     MET T   -19                                                      
REMARK 465     GLY T   -18                                                      
REMARK 465     SER T   -17                                                      
REMARK 465     SER T   -16                                                      
REMARK 465     HIS T   -15                                                      
REMARK 465     HIS T   -14                                                      
REMARK 465     HIS T   -13                                                      
REMARK 465     HIS T   -12                                                      
REMARK 465     HIS T   -11                                                      
REMARK 465     HIS T   -10                                                      
REMARK 465     SER T    -9                                                      
REMARK 465     SER T    -8                                                      
REMARK 465     GLY T    -7                                                      
REMARK 465     LEU T    -6                                                      
REMARK 465     VAL T    -5                                                      
REMARK 465     PRO T    -4                                                      
REMARK 465     ARG T    -3                                                      
REMARK 465     GLY T    -2                                                      
REMARK 465     SER T    -1                                                      
REMARK 465     HIS T     0                                                      
REMARK 465     GLU T   106                                                      
REMARK 465     ARG T   107                                                      
REMARK 465     MET T   108                                                      
REMARK 465     THR T   109                                                      
REMARK 465     GLN T   110                                                      
REMARK 465     VAL T   111                                                      
REMARK 465     SER T   112                                                      
REMARK 465     LEU T   113                                                      
REMARK 465     SER T   114                                                      
REMARK 465     HIS T   115                                                      
REMARK 465     PRO T   116                                                      
REMARK 465     SER T   117                                                      
REMARK 465     PRO T   118                                                      
REMARK 465     GLU T   119                                                      
REMARK 465     SER T   120                                                      
REMARK 465     GLU T   121                                                      
REMARK 465     GLN T   122                                                      
REMARK 465     GLN T   123                                                      
REMARK 465     GLN T   124                                                      
REMARK 465     PHE T   125                                                      
REMARK 465     SER T   126                                                      
REMARK 465     ASP T   127                                                      
REMARK 465     PRO T   128                                                      
REMARK 465     ASP T   129                                                      
REMARK 465     TRP T   130                                                      
REMARK 465     ASP T   131                                                      
REMARK 465     ASN T   132                                                      
REMARK 465     LEU T   133                                                      
REMARK 465     ALA T   134                                                      
REMARK 465     SER T   135                                                      
REMARK 465     MET U   -19                                                      
REMARK 465     GLY U   -18                                                      
REMARK 465     SER U   -17                                                      
REMARK 465     SER U   -16                                                      
REMARK 465     HIS U   -15                                                      
REMARK 465     HIS U   -14                                                      
REMARK 465     HIS U   -13                                                      
REMARK 465     HIS U   -12                                                      
REMARK 465     HIS U   -11                                                      
REMARK 465     HIS U   -10                                                      
REMARK 465     SER U    -9                                                      
REMARK 465     SER U    -8                                                      
REMARK 465     GLY U    -7                                                      
REMARK 465     LEU U    -6                                                      
REMARK 465     VAL U    -5                                                      
REMARK 465     PRO U    -4                                                      
REMARK 465     ARG U    -3                                                      
REMARK 465     GLY U    -2                                                      
REMARK 465     SER U    -1                                                      
REMARK 465     HIS U     0                                                      
REMARK 465     GLU U   106                                                      
REMARK 465     ARG U   107                                                      
REMARK 465     MET U   108                                                      
REMARK 465     THR U   109                                                      
REMARK 465     GLN U   110                                                      
REMARK 465     VAL U   111                                                      
REMARK 465     SER U   112                                                      
REMARK 465     LEU U   113                                                      
REMARK 465     SER U   114                                                      
REMARK 465     HIS U   115                                                      
REMARK 465     PRO U   116                                                      
REMARK 465     SER U   117                                                      
REMARK 465     PRO U   118                                                      
REMARK 465     GLU U   119                                                      
REMARK 465     SER U   120                                                      
REMARK 465     GLU U   121                                                      
REMARK 465     GLN U   122                                                      
REMARK 465     GLN U   123                                                      
REMARK 465     GLN U   124                                                      
REMARK 465     PHE U   125                                                      
REMARK 465     SER U   126                                                      
REMARK 465     ASP U   127                                                      
REMARK 465     PRO U   128                                                      
REMARK 465     ASP U   129                                                      
REMARK 465     TRP U   130                                                      
REMARK 465     ASP U   131                                                      
REMARK 465     ASN U   132                                                      
REMARK 465     LEU U   133                                                      
REMARK 465     ALA U   134                                                      
REMARK 465     SER U   135                                                      
REMARK 465     MET V   -19                                                      
REMARK 465     GLY V   -18                                                      
REMARK 465     SER V   -17                                                      
REMARK 465     SER V   -16                                                      
REMARK 465     HIS V   -15                                                      
REMARK 465     HIS V   -14                                                      
REMARK 465     HIS V   -13                                                      
REMARK 465     HIS V   -12                                                      
REMARK 465     HIS V   -11                                                      
REMARK 465     HIS V   -10                                                      
REMARK 465     SER V    -9                                                      
REMARK 465     SER V    -8                                                      
REMARK 465     GLY V    -7                                                      
REMARK 465     LEU V    -6                                                      
REMARK 465     VAL V    -5                                                      
REMARK 465     PRO V    -4                                                      
REMARK 465     ARG V    -3                                                      
REMARK 465     GLY V    -2                                                      
REMARK 465     SER V    -1                                                      
REMARK 465     HIS V     0                                                      
REMARK 465     GLU V   106                                                      
REMARK 465     ARG V   107                                                      
REMARK 465     MET V   108                                                      
REMARK 465     THR V   109                                                      
REMARK 465     GLN V   110                                                      
REMARK 465     VAL V   111                                                      
REMARK 465     SER V   112                                                      
REMARK 465     LEU V   113                                                      
REMARK 465     SER V   114                                                      
REMARK 465     HIS V   115                                                      
REMARK 465     PRO V   116                                                      
REMARK 465     SER V   117                                                      
REMARK 465     PRO V   118                                                      
REMARK 465     GLU V   119                                                      
REMARK 465     SER V   120                                                      
REMARK 465     GLU V   121                                                      
REMARK 465     GLN V   122                                                      
REMARK 465     GLN V   123                                                      
REMARK 465     GLN V   124                                                      
REMARK 465     PHE V   125                                                      
REMARK 465     SER V   126                                                      
REMARK 465     ASP V   127                                                      
REMARK 465     PRO V   128                                                      
REMARK 465     ASP V   129                                                      
REMARK 465     TRP V   130                                                      
REMARK 465     ASP V   131                                                      
REMARK 465     ASN V   132                                                      
REMARK 465     LEU V   133                                                      
REMARK 465     ALA V   134                                                      
REMARK 465     SER V   135                                                      
REMARK 465     MET W   -19                                                      
REMARK 465     GLY W   -18                                                      
REMARK 465     SER W   -17                                                      
REMARK 465     SER W   -16                                                      
REMARK 465     HIS W   -15                                                      
REMARK 465     HIS W   -14                                                      
REMARK 465     HIS W   -13                                                      
REMARK 465     HIS W   -12                                                      
REMARK 465     HIS W   -11                                                      
REMARK 465     HIS W   -10                                                      
REMARK 465     SER W    -9                                                      
REMARK 465     SER W    -8                                                      
REMARK 465     GLY W    -7                                                      
REMARK 465     LEU W    -6                                                      
REMARK 465     VAL W    -5                                                      
REMARK 465     PRO W    -4                                                      
REMARK 465     ARG W    -3                                                      
REMARK 465     GLY W    -2                                                      
REMARK 465     SER W    -1                                                      
REMARK 465     HIS W     0                                                      
REMARK 465     GLU W   106                                                      
REMARK 465     ARG W   107                                                      
REMARK 465     MET W   108                                                      
REMARK 465     THR W   109                                                      
REMARK 465     GLN W   110                                                      
REMARK 465     VAL W   111                                                      
REMARK 465     SER W   112                                                      
REMARK 465     LEU W   113                                                      
REMARK 465     SER W   114                                                      
REMARK 465     HIS W   115                                                      
REMARK 465     PRO W   116                                                      
REMARK 465     SER W   117                                                      
REMARK 465     PRO W   118                                                      
REMARK 465     GLU W   119                                                      
REMARK 465     SER W   120                                                      
REMARK 465     GLU W   121                                                      
REMARK 465     GLN W   122                                                      
REMARK 465     GLN W   123                                                      
REMARK 465     GLN W   124                                                      
REMARK 465     PHE W   125                                                      
REMARK 465     SER W   126                                                      
REMARK 465     ASP W   127                                                      
REMARK 465     PRO W   128                                                      
REMARK 465     ASP W   129                                                      
REMARK 465     TRP W   130                                                      
REMARK 465     ASP W   131                                                      
REMARK 465     ASN W   132                                                      
REMARK 465     LEU W   133                                                      
REMARK 465     ALA W   134                                                      
REMARK 465     SER W   135                                                      
REMARK 465     MET X   -19                                                      
REMARK 465     GLY X   -18                                                      
REMARK 465     SER X   -17                                                      
REMARK 465     SER X   -16                                                      
REMARK 465     HIS X   -15                                                      
REMARK 465     HIS X   -14                                                      
REMARK 465     HIS X   -13                                                      
REMARK 465     HIS X   -12                                                      
REMARK 465     HIS X   -11                                                      
REMARK 465     HIS X   -10                                                      
REMARK 465     SER X    -9                                                      
REMARK 465     SER X    -8                                                      
REMARK 465     GLY X    -7                                                      
REMARK 465     LEU X    -6                                                      
REMARK 465     VAL X    -5                                                      
REMARK 465     PRO X    -4                                                      
REMARK 465     ARG X    -3                                                      
REMARK 465     GLY X    -2                                                      
REMARK 465     SER X    -1                                                      
REMARK 465     HIS X     0                                                      
REMARK 465     GLU X   106                                                      
REMARK 465     ARG X   107                                                      
REMARK 465     MET X   108                                                      
REMARK 465     THR X   109                                                      
REMARK 465     GLN X   110                                                      
REMARK 465     VAL X   111                                                      
REMARK 465     SER X   112                                                      
REMARK 465     LEU X   113                                                      
REMARK 465     SER X   114                                                      
REMARK 465     HIS X   115                                                      
REMARK 465     PRO X   116                                                      
REMARK 465     SER X   117                                                      
REMARK 465     PRO X   118                                                      
REMARK 465     GLU X   119                                                      
REMARK 465     SER X   120                                                      
REMARK 465     GLU X   121                                                      
REMARK 465     GLN X   122                                                      
REMARK 465     GLN X   123                                                      
REMARK 465     GLN X   124                                                      
REMARK 465     PHE X   125                                                      
REMARK 465     SER X   126                                                      
REMARK 465     ASP X   127                                                      
REMARK 465     PRO X   128                                                      
REMARK 465     ASP X   129                                                      
REMARK 465     TRP X   130                                                      
REMARK 465     ASP X   131                                                      
REMARK 465     ASN X   132                                                      
REMARK 465     LEU X   133                                                      
REMARK 465     ALA X   134                                                      
REMARK 465     SER X   135                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLN A  91    CG   CD   OE1  NE2                                  
REMARK 470     GLN B  91    CG   CD   OE1  NE2                                  
REMARK 470     GLN C  91    CG   CD   OE1  NE2                                  
REMARK 470     GLN D  91    CG   CD   OE1  NE2                                  
REMARK 470     GLN E  91    CG   CD   OE1  NE2                                  
REMARK 470     GLN F  91    CG   CD   OE1  NE2                                  
REMARK 470     GLN G  91    CG   CD   OE1  NE2                                  
REMARK 470     GLN H  91    CG   CD   OE1  NE2                                  
REMARK 470     LYS I  12    CG   CD   CE   NZ                                   
REMARK 470     GLN I  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS I  54    CG   CD   CE   NZ                                   
REMARK 470     GLN I  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU I  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN I 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS I 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU I 105    CG   CD1  CD2                                       
REMARK 470     SER J  45    OG                                                  
REMARK 470     GLN J  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU J  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU J 105    CG   CD1  CD2                                       
REMARK 470     LYS K  12    CG   CD   CE   NZ                                   
REMARK 470     GLN K  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS K  54    CG   CD   CE   NZ                                   
REMARK 470     GLN K  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU K  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG K 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN K 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS K 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU K 105    CG   CD1  CD2                                       
REMARK 470     SER L  45    OG                                                  
REMARK 470     GLN L  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU L  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU L 105    CG   CD1  CD2                                       
REMARK 470     LYS M  12    CG   CD   CE   NZ                                   
REMARK 470     GLN M  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS M  54    CG   CD   CE   NZ                                   
REMARK 470     GLN M  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU M  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG M 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN M 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS M 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU M 105    CG   CD1  CD2                                       
REMARK 470     SER N  45    OG                                                  
REMARK 470     GLN N  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU N  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 105    CG   CD1  CD2                                       
REMARK 470     LYS O  12    CG   CD   CE   NZ                                   
REMARK 470     GLN O  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS O  54    CG   CD   CE   NZ                                   
REMARK 470     GLN O  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU O  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG O 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN O 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS O 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU O 105    CG   CD1  CD2                                       
REMARK 470     SER P  45    OG                                                  
REMARK 470     GLN P  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU P  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU P 105    CG   CD1  CD2                                       
REMARK 470     LYS Q  12    CG   CD   CE   NZ                                   
REMARK 470     GLN Q  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS Q  54    CG   CD   CE   NZ                                   
REMARK 470     GLN Q  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU Q  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG Q 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN Q 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS Q 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU Q 105    CG   CD1  CD2                                       
REMARK 470     SER R  45    OG                                                  
REMARK 470     GLN R  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU R  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU R 105    CG   CD1  CD2                                       
REMARK 470     LYS S  12    CG   CD   CE   NZ                                   
REMARK 470     GLN S  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS S  54    CG   CD   CE   NZ                                   
REMARK 470     GLN S  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU S  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG S 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN S 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS S 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU S 105    CG   CD1  CD2                                       
REMARK 470     SER T  45    OG                                                  
REMARK 470     GLN T  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU T  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU T 105    CG   CD1  CD2                                       
REMARK 470     LYS U  12    CG   CD   CE   NZ                                   
REMARK 470     GLN U  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS U  54    CG   CD   CE   NZ                                   
REMARK 470     GLN U  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU U  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG U 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN U 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS U 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU U 105    CG   CD1  CD2                                       
REMARK 470     SER V  45    OG                                                  
REMARK 470     GLN V  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU V  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU V 105    CG   CD1  CD2                                       
REMARK 470     LYS W  12    CG   CD   CE   NZ                                   
REMARK 470     GLN W  50    CG   CD   OE1  NE2                                  
REMARK 470     LYS W  54    CG   CD   CE   NZ                                   
REMARK 470     GLN W  95    CG   CD   OE1  NE2                                  
REMARK 470     GLU W  99    CG   CD   OE1  OE2                                  
REMARK 470     ARG W 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN W 103    CG   CD   OE1  NE2                                  
REMARK 470     HIS W 104    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU W 105    CG   CD1  CD2                                       
REMARK 470     SER X  45    OG                                                  
REMARK 470     GLN X  50    CG   CD   OE1  NE2                                  
REMARK 470     GLU X  53    CG   CD   OE1  OE2                                  
REMARK 470     LEU X 105    CG   CD1  CD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   C    LYS A    18     CG   GLU S    32              1.49            
REMARK 500   O    LYS A    18     CG   GLU S    32              1.61            
REMARK 500   N    ASP A    19     N    GLU S    32              1.83            
REMARK 500   N    ASP A    19     CA   GLU S    32              1.63            
REMARK 500   N    ASP A    19     CB   GLU S    32              1.31            
REMARK 500   N    ASP A    19     CG   GLU S    32              1.25            
REMARK 500   CA   ASP A    19     CB   GLU S    32              1.03            
REMARK 500   CA   ASP A    19     CG   GLU S    32              1.22            
REMARK 500   CA   ASP A    19     CD   GLU S    32              1.88            
REMARK 500   C    ASP A    19     CB   GLU S    32              1.46            
REMARK 500   C    ASP A    19     CG   GLU S    32              1.70            
REMARK 500   C    ASP A    19     CD   GLU S    32              1.65            
REMARK 500   C    ASP A    19     OE1  GLU S    32              1.80            
REMARK 500   O    ASP A    19     CB   GLU S    32              1.75            
REMARK 500   CB   ASP A    19     CB   GLU S    32              1.79            
REMARK 500   OD1  ASP A    19     O    ALA S    28              1.86            
REMARK 500   OD2  ASP A    19     N    LEU S    30              1.99            
REMARK 500   N    TYR A    20     CD   GLU S    32              1.46            
REMARK 500   N    TYR A    20     OE1  GLU S    32              1.12            
REMARK 500   N    TYR A    20     OE2  GLU S    32              2.13            
REMARK 500   CA   TYR A    20     OE1  GLU S    32              1.74            
REMARK 500   CG   LYS A    21     CG2  THR S    33              1.95            
REMARK 500   NZ   LYS A    21     OG1  THR S    33              1.66            
REMARK 500   NZ   LYS A    21     CB   THR S    33              1.83            
REMARK 500   NZ   LYS A    21     CG2  THR S    33              1.76            
REMARK 500   CB   LEU A    22     O    GLU S    32              1.71            
REMARK 500   CG   LEU A    22     C    GLU S    32              1.69            
REMARK 500   CG   LEU A    22     O    GLU S    32              1.38            
REMARK 500   CG   LEU A    22     N    THR S    33              1.75            
REMARK 500   CG   LEU A    22     CA   THR S    33              1.55            
REMARK 500   CD1  LEU A    22     C    GLU S    32              1.50            
REMARK 500   CD1  LEU A    22     O    GLU S    32              1.20            
REMARK 500   CD1  LEU A    22     N    THR S    33              2.00            
REMARK 500   CD2  LEU A    22     O    THR S    33              1.52            
REMARK 500   CD2  LEU A    22     C    THR S    33              1.33            
REMARK 500   CD2  LEU A    22     CA   THR S    33              1.24            
REMARK 500   O    GLN A    45     CE   MET T     1              2.11            
REMARK 500   OE1  GLN A    45     CD1  LEU T     3              1.49            
REMARK 500   CA   PRO A    46     CE   MET T     1              2.10            
REMARK 500   C    PRO A    46     SD   MET T     1              1.77            
REMARK 500   C    PRO A    46     CE   MET T     1              1.23            
REMARK 500   O    PRO A    46     SD   MET T     1              1.39            
REMARK 500   O    PRO A    46     CE   MET T     1              1.14            
REMARK 500   CB   PRO A    46     CG   GLU S    80              1.94            
REMARK 500   CG   PRO A    46     CG   GLU S    80              1.01            
REMARK 500   CG   PRO A    46     CD   GLU S    80              2.14            
REMARK 500   CG   PRO A    46     CB   GLU S    80              2.01            
REMARK 500   CD   PRO A    46     CG   GLU S    80              1.93            
REMARK 500   CD   PRO A    46     CD   GLU S    80              1.90            
REMARK 500   CD   PRO A    46     OE1  GLU S    80              1.85            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS    1001 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    ILE A 465   C     LYS A 466   N      -0.238                       
REMARK 500    LYS A 466   C     PHE A 467   N      -0.274                       
REMARK 500    PHE A 467   C     GLU A 468   N       1.754                       
REMARK 500    PHE A 469   C     GLU A 470   N       1.336                       
REMARK 500    THR A 471   C     MET A 472   N       0.480                       
REMARK 500    MET A 472   C     ASP A 473   N       1.560                       
REMARK 500    ILE B 465   C     LYS B 466   N      -0.238                       
REMARK 500    LYS B 466   C     PHE B 467   N      -0.274                       
REMARK 500    PHE B 467   C     GLU B 468   N       1.754                       
REMARK 500    PHE B 469   C     GLU B 470   N       1.337                       
REMARK 500    THR B 471   C     MET B 472   N       0.479                       
REMARK 500    MET B 472   C     ASP B 473   N       1.560                       
REMARK 500    ILE C 465   C     LYS C 466   N      -0.238                       
REMARK 500    LYS C 466   C     PHE C 467   N      -0.273                       
REMARK 500    PHE C 467   C     GLU C 468   N       1.755                       
REMARK 500    PHE C 469   C     GLU C 470   N       1.336                       
REMARK 500    THR C 471   C     MET C 472   N       0.479                       
REMARK 500    MET C 472   C     ASP C 473   N       1.560                       
REMARK 500    ILE D 465   C     LYS D 466   N      -0.238                       
REMARK 500    LYS D 466   C     PHE D 467   N      -0.273                       
REMARK 500    PHE D 467   C     GLU D 468   N       1.754                       
REMARK 500    PHE D 469   C     GLU D 470   N       1.337                       
REMARK 500    THR D 471   C     MET D 472   N       0.480                       
REMARK 500    MET D 472   C     ASP D 473   N       1.560                       
REMARK 500    ILE E 465   C     LYS E 466   N      -0.237                       
REMARK 500    LYS E 466   C     PHE E 467   N      -0.273                       
REMARK 500    PHE E 467   C     GLU E 468   N       1.754                       
REMARK 500    PHE E 469   C     GLU E 470   N       1.337                       
REMARK 500    THR E 471   C     MET E 472   N       0.480                       
REMARK 500    MET E 472   C     ASP E 473   N       1.561                       
REMARK 500    ILE F 465   C     LYS F 466   N      -0.238                       
REMARK 500    LYS F 466   C     PHE F 467   N      -0.274                       
REMARK 500    PHE F 467   C     GLU F 468   N       1.754                       
REMARK 500    PHE F 469   C     GLU F 470   N       1.336                       
REMARK 500    THR F 471   C     MET F 472   N       0.480                       
REMARK 500    MET F 472   C     ASP F 473   N       1.561                       
REMARK 500    ILE G 465   C     LYS G 466   N      -0.238                       
REMARK 500    LYS G 466   C     PHE G 467   N      -0.273                       
REMARK 500    PHE G 467   C     GLU G 468   N       1.754                       
REMARK 500    PHE G 469   C     GLU G 470   N       1.336                       
REMARK 500    THR G 471   C     MET G 472   N       0.480                       
REMARK 500    MET G 472   C     ASP G 473   N       1.560                       
REMARK 500    ILE H 465   C     LYS H 466   N      -0.238                       
REMARK 500    LYS H 466   C     PHE H 467   N      -0.274                       
REMARK 500    PHE H 467   C     GLU H 468   N       1.754                       
REMARK 500    PHE H 469   C     GLU H 470   N       1.336                       
REMARK 500    THR H 471   C     MET H 472   N       0.480                       
REMARK 500    MET H 472   C     ASP H 473   N       1.561                       
REMARK 500    ASN J  34   CG    ASN J  34   ND2     0.159                       
REMARK 500    PRO J  36   C     LEU J  37   N       0.201                       
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      64 BOND DEVIATIONS.                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A  36   CA  -  CB  -  CG  ANGL. DEV. =  15.3 DEGREES          
REMARK 500    ARG A 159   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500    ARG A 217   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.9 DEGREES          
REMARK 500    ARG A 285   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500    ARG A 312   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.9 DEGREES          
REMARK 500    ILE A 465   CA  -  C   -  N   ANGL. DEV. =  17.8 DEGREES          
REMARK 500    ILE A 465   O   -  C   -  N   ANGL. DEV. = -19.4 DEGREES          
REMARK 500    LYS A 466   CA  -  C   -  N   ANGL. DEV. =  35.2 DEGREES          
REMARK 500    LYS A 466   O   -  C   -  N   ANGL. DEV. = -36.0 DEGREES          
REMARK 500    PHE A 467   CA  -  C   -  N   ANGL. DEV. = -88.0 DEGREES          
REMARK 500    PHE A 467   O   -  C   -  N   ANGL. DEV. =  24.7 DEGREES          
REMARK 500    PHE A 469   CA  -  C   -  N   ANGL. DEV. = -60.5 DEGREES          
REMARK 500    PHE A 469   O   -  C   -  N   ANGL. DEV. = -58.9 DEGREES          
REMARK 500    GLU A 470   C   -  N   -  CA  ANGL. DEV. =  27.1 DEGREES          
REMARK 500    THR A 471   CA  -  C   -  N   ANGL. DEV. = -20.8 DEGREES          
REMARK 500    THR A 471   O   -  C   -  N   ANGL. DEV. =  19.9 DEGREES          
REMARK 500    MET A 472   CA  -  C   -  N   ANGL. DEV. = -57.0 DEGREES          
REMARK 500    MET A 472   O   -  C   -  N   ANGL. DEV. =  18.6 DEGREES          
REMARK 500    LEU B  36   CA  -  CB  -  CG  ANGL. DEV. =  15.3 DEGREES          
REMARK 500    ARG B 159   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500    ARG B 217   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500    ARG B 285   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500    ARG B 312   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.9 DEGREES          
REMARK 500    ILE B 465   CA  -  C   -  N   ANGL. DEV. =  17.9 DEGREES          
REMARK 500    ILE B 465   O   -  C   -  N   ANGL. DEV. = -19.4 DEGREES          
REMARK 500    LYS B 466   CA  -  C   -  N   ANGL. DEV. =  35.2 DEGREES          
REMARK 500    LYS B 466   O   -  C   -  N   ANGL. DEV. = -36.0 DEGREES          
REMARK 500    PHE B 467   CA  -  C   -  N   ANGL. DEV. = -88.0 DEGREES          
REMARK 500    PHE B 467   O   -  C   -  N   ANGL. DEV. =  24.6 DEGREES          
REMARK 500    PHE B 469   CA  -  C   -  N   ANGL. DEV. = -60.6 DEGREES          
REMARK 500    PHE B 469   O   -  C   -  N   ANGL. DEV. = -58.9 DEGREES          
REMARK 500    GLU B 470   C   -  N   -  CA  ANGL. DEV. =  27.1 DEGREES          
REMARK 500    THR B 471   CA  -  C   -  N   ANGL. DEV. = -20.8 DEGREES          
REMARK 500    THR B 471   O   -  C   -  N   ANGL. DEV. =  19.9 DEGREES          
REMARK 500    MET B 472   CA  -  C   -  N   ANGL. DEV. = -57.0 DEGREES          
REMARK 500    MET B 472   O   -  C   -  N   ANGL. DEV. =  18.6 DEGREES          
REMARK 500    LEU C  36   CA  -  CB  -  CG  ANGL. DEV. =  15.2 DEGREES          
REMARK 500    ARG C 159   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500    ARG C 217   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.9 DEGREES          
REMARK 500    ARG C 285   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500    ARG C 312   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.9 DEGREES          
REMARK 500    ILE C 465   CA  -  C   -  N   ANGL. DEV. =  17.9 DEGREES          
REMARK 500    ILE C 465   O   -  C   -  N   ANGL. DEV. = -19.5 DEGREES          
REMARK 500    LYS C 466   CA  -  C   -  N   ANGL. DEV. =  35.2 DEGREES          
REMARK 500    LYS C 466   O   -  C   -  N   ANGL. DEV. = -36.1 DEGREES          
REMARK 500    PHE C 467   CA  -  C   -  N   ANGL. DEV. = -88.1 DEGREES          
REMARK 500    PHE C 467   O   -  C   -  N   ANGL. DEV. =  24.7 DEGREES          
REMARK 500    PHE C 469   CA  -  C   -  N   ANGL. DEV. = -60.5 DEGREES          
REMARK 500    PHE C 469   O   -  C   -  N   ANGL. DEV. = -58.9 DEGREES          
REMARK 500    GLU C 470   C   -  N   -  CA  ANGL. DEV. =  27.2 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     144 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A  62      -77.28   -134.90                                   
REMARK 500    HIS A 153      -57.29   -132.48                                   
REMARK 500    CYS A 172      124.27   -172.90                                   
REMARK 500    ASN A 207      -85.78   -122.64                                   
REMARK 500    GLN A 212      101.16   -164.62                                   
REMARK 500    MET A 297       -8.58     93.68                                   
REMARK 500    VAL A 331      -47.24     70.78                                   
REMARK 500    ASP A 357       98.22   -161.62                                   
REMARK 500    PHE A 467       89.57     51.95                                   
REMARK 500    MET A 472      -81.24    -87.78                                   
REMARK 500    ASP A 473       65.70    -41.11                                   
REMARK 500    SER B  62      -77.34   -134.91                                   
REMARK 500    HIS B 153      -57.34   -132.48                                   
REMARK 500    CYS B 172      124.25   -172.92                                   
REMARK 500    ASN B 207      -85.79   -122.66                                   
REMARK 500    GLN B 212      101.19   -164.66                                   
REMARK 500    MET B 297       -8.60     93.67                                   
REMARK 500    VAL B 331      -47.22     70.77                                   
REMARK 500    ASP B 357       98.25   -161.56                                   
REMARK 500    PHE B 467       89.55     51.91                                   
REMARK 500    MET B 472      -81.25    -87.78                                   
REMARK 500    ASP B 473       65.72    -41.16                                   
REMARK 500    SER C  62      -77.32   -134.86                                   
REMARK 500    HIS C 153      -57.25   -132.50                                   
REMARK 500    CYS C 172      124.23   -172.87                                   
REMARK 500    ASN C 207      -85.79   -122.61                                   
REMARK 500    GLN C 212      101.17   -164.62                                   
REMARK 500    MET C 297       -8.59     93.69                                   
REMARK 500    VAL C 331      -47.34     70.85                                   
REMARK 500    ASP C 357       98.17   -161.60                                   
REMARK 500    PHE C 467       89.59     51.90                                   
REMARK 500    MET C 472      -81.24    -87.80                                   
REMARK 500    ASP C 473       65.67    -41.12                                   
REMARK 500    SER D  62      -77.26   -134.92                                   
REMARK 500    HIS D 153      -57.27   -132.47                                   
REMARK 500    CYS D 172      124.31   -172.89                                   
REMARK 500    ASN D 207      -85.79   -122.63                                   
REMARK 500    GLN D 212      101.14   -164.68                                   
REMARK 500    MET D 297       -8.54     93.65                                   
REMARK 500    VAL D 331      -47.22     70.74                                   
REMARK 500    ASP D 357       98.23   -161.58                                   
REMARK 500    PHE D 467       89.55     51.95                                   
REMARK 500    MET D 472      -81.23    -87.79                                   
REMARK 500    ASP D 473       65.67    -41.09                                   
REMARK 500    SER E  62      -77.33   -134.92                                   
REMARK 500    HIS E 153      -57.29   -132.52                                   
REMARK 500    CYS E 172      124.26   -172.88                                   
REMARK 500    ASN E 207      -85.80   -122.62                                   
REMARK 500    GLN E 212      101.22   -164.58                                   
REMARK 500    MET E 297       -8.58     93.71                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     112 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 LYS A  466     PHE A  467                  -42.07                    
REMARK 500 PHE A  469     GLU A  470                 -121.57                    
REMARK 500 LYS B  466     PHE B  467                  -41.98                    
REMARK 500 PHE B  469     GLU B  470                 -121.54                    
REMARK 500 LYS C  466     PHE C  467                  -42.12                    
REMARK 500 PHE C  469     GLU C  470                 -121.57                    
REMARK 500 LYS D  466     PHE D  467                  -42.05                    
REMARK 500 PHE D  469     GLU D  470                 -121.60                    
REMARK 500 LYS E  466     PHE E  467                  -42.14                    
REMARK 500 PHE E  469     GLU E  470                 -121.65                    
REMARK 500 LYS F  466     PHE F  467                  -41.97                    
REMARK 500 PHE F  469     GLU F  470                 -121.63                    
REMARK 500 LYS G  466     PHE G  467                  -42.03                    
REMARK 500 PHE G  469     GLU G  470                 -121.56                    
REMARK 500 LYS H  466     PHE H  467                  -42.13                    
REMARK 500 PHE H  469     GLU H  470                 -121.51                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    ARG A  41         0.20    SIDE CHAIN                              
REMARK 500    ARG A 131         0.11    SIDE CHAIN                              
REMARK 500    ARG A 134         0.18    SIDE CHAIN                              
REMARK 500    ARG A 159         0.24    SIDE CHAIN                              
REMARK 500    ARG A 167         0.16    SIDE CHAIN                              
REMARK 500    ARG A 194         0.15    SIDE CHAIN                              
REMARK 500    ARG A 213         0.16    SIDE CHAIN                              
REMARK 500    ARG A 215         0.24    SIDE CHAIN                              
REMARK 500    ARG A 217         0.22    SIDE CHAIN                              
REMARK 500    ARG A 285         0.16    SIDE CHAIN                              
REMARK 500    ARG A 295         0.08    SIDE CHAIN                              
REMARK 500    ARG A 305         0.11    SIDE CHAIN                              
REMARK 500    ARG A 312         0.19    SIDE CHAIN                              
REMARK 500    ARG A 319         0.10    SIDE CHAIN                              
REMARK 500    ARG A 350         0.10    SIDE CHAIN                              
REMARK 500    ARG A 360         0.10    SIDE CHAIN                              
REMARK 500    ARG A 446         0.10    SIDE CHAIN                              
REMARK 500    ARG B  41         0.20    SIDE CHAIN                              
REMARK 500    ARG B 131         0.11    SIDE CHAIN                              
REMARK 500    ARG B 134         0.18    SIDE CHAIN                              
REMARK 500    ARG B 159         0.23    SIDE CHAIN                              
REMARK 500    ARG B 167         0.16    SIDE CHAIN                              
REMARK 500    ARG B 194         0.15    SIDE CHAIN                              
REMARK 500    ARG B 213         0.16    SIDE CHAIN                              
REMARK 500    ARG B 215         0.24    SIDE CHAIN                              
REMARK 500    ARG B 217         0.22    SIDE CHAIN                              
REMARK 500    ARG B 285         0.16    SIDE CHAIN                              
REMARK 500    ARG B 295         0.08    SIDE CHAIN                              
REMARK 500    ARG B 305         0.11    SIDE CHAIN                              
REMARK 500    ARG B 312         0.19    SIDE CHAIN                              
REMARK 500    ARG B 319         0.10    SIDE CHAIN                              
REMARK 500    ARG B 350         0.10    SIDE CHAIN                              
REMARK 500    ARG B 360         0.10    SIDE CHAIN                              
REMARK 500    ARG B 446         0.10    SIDE CHAIN                              
REMARK 500    ARG C  41         0.20    SIDE CHAIN                              
REMARK 500    ARG C 131         0.11    SIDE CHAIN                              
REMARK 500    ARG C 134         0.18    SIDE CHAIN                              
REMARK 500    ARG C 159         0.24    SIDE CHAIN                              
REMARK 500    ARG C 167         0.16    SIDE CHAIN                              
REMARK 500    ARG C 194         0.15    SIDE CHAIN                              
REMARK 500    ARG C 213         0.16    SIDE CHAIN                              
REMARK 500    ARG C 215         0.24    SIDE CHAIN                              
REMARK 500    ARG C 217         0.22    SIDE CHAIN                              
REMARK 500    ARG C 285         0.16    SIDE CHAIN                              
REMARK 500    ARG C 295         0.08    SIDE CHAIN                              
REMARK 500    ARG C 305         0.11    SIDE CHAIN                              
REMARK 500    ARG C 312         0.19    SIDE CHAIN                              
REMARK 500    ARG C 319         0.10    SIDE CHAIN                              
REMARK 500    ARG C 350         0.10    SIDE CHAIN                              
REMARK 500    ARG C 360         0.10    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     136 PLANE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    PHE A 467         17.74                                           
REMARK 500    MET A 472         18.89                                           
REMARK 500    PHE B 467         17.75                                           
REMARK 500    MET B 472         18.88                                           
REMARK 500    PHE C 467         17.72                                           
REMARK 500    MET C 472         18.87                                           
REMARK 500    PHE D 467         17.73                                           
REMARK 500    MET D 472         18.91                                           
REMARK 500    PHE E 467         17.70                                           
REMARK 500    MET E 472         18.90                                           
REMARK 500    PHE F 467         17.75                                           
REMARK 500    MET F 472         18.88                                           
REMARK 500    PHE G 467         17.71                                           
REMARK 500    MET G 472         18.91                                           
REMARK 500    PHE H 467         17.71                                           
REMARK 500    MET H 472         18.89                                           
REMARK 500    PRO J  36         12.81                                           
REMARK 500    PRO L  36         12.81                                           
REMARK 500    PRO N  36         12.81                                           
REMARK 500    PRO P  36         12.81                                           
REMARK 500    PRO R  36         12.81                                           
REMARK 500    PRO T  36         12.81                                           
REMARK 500    PRO V  36         12.81                                           
REMARK 500    PRO X  36         12.81                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1RSC   RELATED DB: PDB                                   
REMARK 900  RIBULOSE-1,5-BISPHOSPHATE CARBOXYLASE/                              
REMARK 900  OXYGENASE (RUBISCO)                                                 
REMARK 900 RELATED ID: 1RBL   RELATED DB: PDB                                   
REMARK 900  RIBULOSE 1,5 BISPHOSPHATE CARBOXYLASE/                              
REMARK 900  OXYGENASE (RUBISCO)                                                 
REMARK 900 RELATED ID: EMD-1655   RELATED DB: EMDB                              
DBREF  2WVW A    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW B    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW C    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW D    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW E    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW F    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW G    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW H    4   475  UNP    P00880   RBL_SYNP6        1    472             
DBREF  2WVW I  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW I    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW J  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW J    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW K  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW K    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW L  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW L    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW M  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW M    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW N  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW N    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW O  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW O    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW P  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW P    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW Q  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW Q    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW R  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW R    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW S  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW S    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW T  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW T    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW U  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW U    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW V  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW V    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW W  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW W    1   135  UNP    Q44212   Q44212_9NOST     1    135             
DBREF  2WVW X  -19     0  PDB    2WVW     2WVW           -19      0             
DBREF  2WVW X    1   135  UNP    Q44212   Q44212_9NOST     1    135             
SEQRES   1 A  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 A  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 A  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 A  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 A  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 A  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 A  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 A  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 A  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 A  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 A  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 A  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 A  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 A  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 A  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 A  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 A  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 A  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 A  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 A  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 A  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 A  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 A  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 A  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 A  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 A  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 A  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 A  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 A  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 A  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 A  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 A  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 A  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 A  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 A  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 A  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 A  472  MET ASP LYS LEU                                              
SEQRES   1 B  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 B  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 B  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 B  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 B  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 B  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 B  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 B  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 B  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 B  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 B  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 B  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 B  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 B  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 B  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 B  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 B  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 B  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 B  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 B  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 B  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 B  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 B  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 B  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 B  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 B  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 B  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 B  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 B  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 B  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 B  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 B  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 B  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 B  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 B  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 B  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 B  472  MET ASP LYS LEU                                              
SEQRES   1 C  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 C  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 C  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 C  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 C  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 C  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 C  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 C  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 C  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 C  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 C  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 C  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 C  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 C  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 C  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 C  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 C  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 C  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 C  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 C  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 C  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 C  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 C  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 C  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 C  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 C  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 C  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 C  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 C  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 C  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 C  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 C  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 C  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 C  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 C  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 C  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 C  472  MET ASP LYS LEU                                              
SEQRES   1 D  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 D  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 D  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 D  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 D  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 D  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 D  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 D  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 D  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 D  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 D  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 D  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 D  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 D  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 D  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 D  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 D  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 D  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 D  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 D  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 D  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 D  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 D  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 D  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 D  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 D  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 D  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 D  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 D  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 D  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 D  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 D  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 D  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 D  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 D  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 D  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 D  472  MET ASP LYS LEU                                              
SEQRES   1 E  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 E  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 E  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 E  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 E  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 E  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 E  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 E  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 E  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 E  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 E  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 E  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 E  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 E  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 E  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 E  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 E  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 E  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 E  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 E  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 E  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 E  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 E  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 E  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 E  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 E  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 E  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 E  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 E  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 E  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 E  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 E  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 E  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 E  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 E  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 E  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 E  472  MET ASP LYS LEU                                              
SEQRES   1 F  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 F  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 F  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 F  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 F  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 F  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 F  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 F  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 F  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 F  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 F  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 F  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 F  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 F  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 F  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 F  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 F  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 F  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 F  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 F  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 F  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 F  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 F  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 F  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 F  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 F  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 F  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 F  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 F  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 F  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 F  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 F  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 F  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 F  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 F  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 F  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 F  472  MET ASP LYS LEU                                              
SEQRES   1 G  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 G  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 G  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 G  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 G  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 G  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 G  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 G  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 G  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 G  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 G  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 G  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 G  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 G  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 G  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 G  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 G  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 G  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 G  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 G  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 G  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 G  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 G  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 G  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 G  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 G  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 G  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 G  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 G  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 G  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 G  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 G  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 G  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 G  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 G  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 G  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 G  472  MET ASP LYS LEU                                              
SEQRES   1 H  472  MET PRO LYS THR GLN SER ALA ALA GLY TYR LYS ALA GLY          
SEQRES   2 H  472  VAL LYS ASP TYR LYS LEU THR TYR TYR THR PRO ASP TYR          
SEQRES   3 H  472  THR PRO LYS ASP THR ASP LEU LEU ALA ALA PHE ARG PHE          
SEQRES   4 H  472  SER PRO GLN PRO GLY VAL PRO ALA ASP GLU ALA GLY ALA          
SEQRES   5 H  472  ALA ILE ALA ALA GLU SER SER THR GLY THR TRP THR THR          
SEQRES   6 H  472  VAL TRP THR ASP LEU LEU THR ASP MET ASP ARG TYR LYS          
SEQRES   7 H  472  GLY LYS CYS TYR HIS ILE GLU PRO VAL GLN GLY GLU GLU          
SEQRES   8 H  472  ASN SER TYR PHE ALA PHE ILE ALA TYR PRO LEU ASP LEU          
SEQRES   9 H  472  PHE GLU GLU GLY SER VAL THR ASN ILE LEU THR SER ILE          
SEQRES  10 H  472  VAL GLY ASN VAL PHE GLY PHE LYS ALA ILE ARG SER LEU          
SEQRES  11 H  472  ARG LEU GLU ASP ILE ARG PHE PRO VAL ALA LEU VAL LYS          
SEQRES  12 H  472  THR PHE GLN GLY PRO PRO HIS GLY ILE GLN VAL GLU ARG          
SEQRES  13 H  472  ASP LEU LEU ASN LYS TYR GLY ARG PRO MET LEU GLY CYS          
SEQRES  14 H  472  THR ILE LYS PRO LYS LEU GLY LEU SER ALA LYS ASN TYR          
SEQRES  15 H  472  GLY ARG ALA VAL TYR GLU CYS LEU ARG GLY GLY LEU ASP          
SEQRES  16 H  472  PHE THR LYS ASP ASP GLU ASN ILE ASN SER GLN PRO PHE          
SEQRES  17 H  472  GLN ARG TRP ARG ASP ARG PHE LEU PHE VAL ALA ASP ALA          
SEQRES  18 H  472  ILE HIS LYS SER GLN ALA GLU THR GLY GLU ILE LYS GLY          
SEQRES  19 H  472  HIS TYR LEU ASN VAL THR ALA PRO THR CYS GLU GLU MET          
SEQRES  20 H  472  MET LYS ARG ALA GLU PHE ALA LYS GLU LEU GLY MET PRO          
SEQRES  21 H  472  ILE ILE MET HIS ASP PHE LEU THR ALA GLY PHE THR ALA          
SEQRES  22 H  472  ASN THR THR LEU ALA LYS TRP CYS ARG ASP ASN GLY VAL          
SEQRES  23 H  472  LEU LEU HIS ILE HIS ARG ALA MET HIS ALA VAL ILE ASP          
SEQRES  24 H  472  ARG GLN ARG ASN HIS GLY ILE HIS PHE ARG VAL LEU ALA          
SEQRES  25 H  472  LYS CYS LEU ARG LEU SER GLY GLY ASP HIS LEU HIS SER          
SEQRES  26 H  472  GLY THR VAL VAL GLY LYS LEU GLU GLY ASP LYS ALA SER          
SEQRES  27 H  472  THR LEU GLY PHE VAL ASP LEU MET ARG GLU ASP HIS ILE          
SEQRES  28 H  472  GLU ALA ASP ARG SER ARG GLY VAL PHE PHE THR GLN ASP          
SEQRES  29 H  472  TRP ALA SER MET PRO GLY VAL LEU PRO VAL ALA SER GLY          
SEQRES  30 H  472  GLY ILE HIS VAL TRP HIS MET PRO ALA LEU VAL GLU ILE          
SEQRES  31 H  472  PHE GLY ASP ASP SER VAL LEU GLN PHE GLY GLY GLY THR          
SEQRES  32 H  472  LEU GLY HIS PRO TRP GLY ASN ALA PRO GLY ALA THR ALA          
SEQRES  33 H  472  ASN ARG VAL ALA LEU GLU ALA CYS VAL GLN ALA ARG ASN          
SEQRES  34 H  472  GLU GLY ARG ASP LEU TYR ARG GLU GLY GLY ASP ILE LEU          
SEQRES  35 H  472  ARG GLU ALA GLY LYS TRP SER PRO GLU LEU ALA ALA ALA          
SEQRES  36 H  472  LEU ASP LEU TRP LYS GLU ILE LYS PHE GLU PHE GLU THR          
SEQRES  37 H  472  MET ASP LYS LEU                                              
SEQRES   1 I  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 I  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 I  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 I  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 I  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 I  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 I  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 I  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 I  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 I  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 I  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 I  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 J  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 J  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 J  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 J  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 J  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 J  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 J  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 J  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 J  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 J  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 J  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 J  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 K  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 K  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 K  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 K  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 K  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 K  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 K  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 K  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 K  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 K  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 K  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 K  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 L  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 L  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 L  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 L  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 L  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 L  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 L  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 L  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 L  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 L  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 L  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 L  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 M  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 M  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 M  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 M  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 M  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 M  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 M  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 M  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 M  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 M  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 M  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 M  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 N  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 N  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 N  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 N  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 N  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 N  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 N  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 N  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 N  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 N  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 N  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 N  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 O  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 O  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 O  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 O  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 O  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 O  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 O  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 O  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 O  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 O  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 O  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 O  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 P  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 P  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 P  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 P  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 P  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 P  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 P  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 P  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 P  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 P  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 P  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 P  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 Q  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 Q  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 Q  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 Q  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 Q  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 Q  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 Q  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 Q  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 Q  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 Q  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 Q  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 Q  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 R  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 R  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 R  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 R  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 R  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 R  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 R  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 R  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 R  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 R  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 R  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 R  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 S  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 S  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 S  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 S  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 S  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 S  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 S  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 S  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 S  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 S  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 S  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 S  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 T  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 T  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 T  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 T  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 T  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 T  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 T  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 T  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 T  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 T  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 T  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 T  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 U  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 U  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 U  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 U  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 U  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 U  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 U  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 U  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 U  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 U  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 U  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 U  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 V  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 V  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 V  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 V  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 V  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 V  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 V  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 V  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 V  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 V  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 V  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 V  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 W  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 W  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 W  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 W  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 W  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 W  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 W  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 W  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 W  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 W  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 W  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 W  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
SEQRES   1 X  155  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 X  155  LEU VAL PRO ARG GLY SER HIS MET ASN LEU LYS GLN ILE          
SEQRES   3 X  155  ALA LYS ASP THR ALA LYS THR LEU GLN SER TYR LEU THR          
SEQRES   4 X  155  TYR GLN ALA LEU ARG THR VAL LEU ALA GLN LEU GLY GLU          
SEQRES   5 X  155  THR ASN PRO PRO LEU ALA LEU TRP LEU HIS ASN PHE SER          
SEQRES   6 X  155  ALA GLY LYS VAL GLN ASP GLY GLU LYS TYR ILE GLU GLU          
SEQRES   7 X  155  LEU PHE LEU GLU LYS PRO ASP LEU ALA LEU ARG ILE MET          
SEQRES   8 X  155  THR VAL ARG GLU HIS ILE ALA GLU GLU ILE ALA GLU PHE          
SEQRES   9 X  155  LEU PRO GLU MET VAL VAL THR GLY ILE GLN GLN ALA ASN          
SEQRES  10 X  155  MET GLU LYS ARG ARG GLN HIS LEU GLU ARG MET THR GLN          
SEQRES  11 X  155  VAL SER LEU SER HIS PRO SER PRO GLU SER GLU GLN GLN          
SEQRES  12 X  155  GLN PHE SER ASP PRO ASP TRP ASP ASN LEU ALA SER              
HELIX    1   1 TYR A   20  TYR A   25  1                                   6    
HELIX    2   2 PRO A   49  SER A   61  1                                  13    
HELIX    3   3 VAL A   69  THR A   75  5                                   7    
HELIX    4   4 ASP A   76  LYS A   81  1                                   6    
HELIX    5   5 PRO A  104  PHE A  108  5                                   5    
HELIX    6   6 SER A  112  GLY A  122  1                                  11    
HELIX    7   7 ASN A  123  GLY A  126  5                                   4    
HELIX    8   8 PRO A  141  LYS A  146  1                                   6    
HELIX    9   9 GLY A  154  ASN A  163  1                                  10    
HELIX   10  10 SER A  181  GLY A  195  1                                  15    
HELIX   11  11 ARG A  213  GLY A  233  1                                  21    
HELIX   12  12 THR A  246  LEU A  260  1                                  15    
HELIX   13  13 PHE A  269  GLY A  288  1                                  20    
HELIX   14  14 MET A  297  ARG A  303  1                                   7    
HELIX   15  15 HIS A  310  GLY A  322  1                                  13    
HELIX   16  16 ASP A  338  GLU A  351  1                                  14    
HELIX   17  17 ARG A  358  GLY A  361  5                                   4    
HELIX   18  18 HIS A  383  TRP A  385  5                                   3    
HELIX   19  19 HIS A  386  GLY A  395  1                                  10    
HELIX   20  20 GLY A  403  GLY A  408  1                                   6    
HELIX   21  21 GLY A  412  GLY A  434  1                                  23    
HELIX   22  22 ASP A  436  LYS A  463  1                                  28    
HELIX   23  23 TYR B   20  TYR B   25  1                                   6    
HELIX   24  24 PRO B   49  SER B   61  1                                  13    
HELIX   25  25 VAL B   69  THR B   75  5                                   7    
HELIX   26  26 ASP B   76  LYS B   81  1                                   6    
HELIX   27  27 PRO B  104  PHE B  108  5                                   5    
HELIX   28  28 SER B  112  GLY B  122  1                                  11    
HELIX   29  29 ASN B  123  GLY B  126  5                                   4    
HELIX   30  30 PRO B  141  LYS B  146  1                                   6    
HELIX   31  31 GLY B  154  ASN B  163  1                                  10    
HELIX   32  32 SER B  181  GLY B  195  1                                  15    
HELIX   33  33 ARG B  213  GLY B  233  1                                  21    
HELIX   34  34 THR B  246  LEU B  260  1                                  15    
HELIX   35  35 PHE B  269  GLY B  288  1                                  20    
HELIX   36  36 MET B  297  ARG B  303  1                                   7    
HELIX   37  37 HIS B  310  GLY B  322  1                                  13    
HELIX   38  38 ASP B  338  GLU B  351  1                                  14    
HELIX   39  39 ARG B  358  GLY B  361  5                                   4    
HELIX   40  40 HIS B  383  TRP B  385  5                                   3    
HELIX   41  41 HIS B  386  GLY B  395  1                                  10    
HELIX   42  42 GLY B  403  GLY B  408  1                                   6    
HELIX   43  43 GLY B  412  GLY B  434  1                                  23    
HELIX   44  44 ASP B  436  LYS B  463  1                                  28    
HELIX   45  45 TYR C   20  TYR C   25  1                                   6    
HELIX   46  46 PRO C   49  SER C   61  1                                  13    
HELIX   47  47 VAL C   69  THR C   75  5                                   7    
HELIX   48  48 ASP C   76  LYS C   81  1                                   6    
HELIX   49  49 PRO C  104  PHE C  108  5                                   5    
HELIX   50  50 SER C  112  GLY C  122  1                                  11    
HELIX   51  51 ASN C  123  GLY C  126  5                                   4    
HELIX   52  52 PRO C  141  LYS C  146  1                                   6    
HELIX   53  53 GLY C  154  ASN C  163  1                                  10    
HELIX   54  54 SER C  181  GLY C  195  1                                  15    
HELIX   55  55 ARG C  213  GLY C  233  1                                  21    
HELIX   56  56 THR C  246  LEU C  260  1                                  15    
HELIX   57  57 PHE C  269  GLY C  288  1                                  20    
HELIX   58  58 MET C  297  ARG C  303  1                                   7    
HELIX   59  59 HIS C  310  GLY C  322  1                                  13    
HELIX   60  60 ASP C  338  GLU C  351  1                                  14    
HELIX   61  61 ARG C  358  GLY C  361  5                                   4    
HELIX   62  62 HIS C  383  TRP C  385  5                                   3    
HELIX   63  63 HIS C  386  GLY C  395  1                                  10    
HELIX   64  64 GLY C  403  GLY C  408  1                                   6    
HELIX   65  65 GLY C  412  GLY C  434  1                                  23    
HELIX   66  66 ASP C  436  LYS C  463  1                                  28    
HELIX   67  67 TYR D   20  TYR D   25  1                                   6    
HELIX   68  68 PRO D   49  SER D   61  1                                  13    
HELIX   69  69 VAL D   69  THR D   75  5                                   7    
HELIX   70  70 ASP D   76  LYS D   81  1                                   6    
HELIX   71  71 PRO D  104  PHE D  108  5                                   5    
HELIX   72  72 SER D  112  GLY D  122  1                                  11    
HELIX   73  73 ASN D  123  GLY D  126  5                                   4    
HELIX   74  74 PRO D  141  LYS D  146  1                                   6    
HELIX   75  75 GLY D  154  ASN D  163  1                                  10    
HELIX   76  76 SER D  181  GLY D  195  1                                  15    
HELIX   77  77 ARG D  213  GLY D  233  1                                  21    
HELIX   78  78 THR D  246  LEU D  260  1                                  15    
HELIX   79  79 PHE D  269  GLY D  288  1                                  20    
HELIX   80  80 MET D  297  ARG D  303  1                                   7    
HELIX   81  81 HIS D  310  GLY D  322  1                                  13    
HELIX   82  82 ASP D  338  GLU D  351  1                                  14    
HELIX   83  83 ARG D  358  GLY D  361  5                                   4    
HELIX   84  84 HIS D  383  TRP D  385  5                                   3    
HELIX   85  85 HIS D  386  GLY D  395  1                                  10    
HELIX   86  86 GLY D  403  GLY D  408  1                                   6    
HELIX   87  87 GLY D  412  GLY D  434  1                                  23    
HELIX   88  88 ASP D  436  LYS D  463  1                                  28    
HELIX   89  89 TYR E   20  TYR E   25  1                                   6    
HELIX   90  90 PRO E   49  SER E   61  1                                  13    
HELIX   91  91 VAL E   69  THR E   75  5                                   7    
HELIX   92  92 ASP E   76  LYS E   81  1                                   6    
HELIX   93  93 PRO E  104  PHE E  108  5                                   5    
HELIX   94  94 SER E  112  GLY E  122  1                                  11    
HELIX   95  95 ASN E  123  GLY E  126  5                                   4    
HELIX   96  96 PRO E  141  LYS E  146  1                                   6    
HELIX   97  97 GLY E  154  ASN E  163  1                                  10    
HELIX   98  98 SER E  181  GLY E  195  1                                  15    
HELIX   99  99 ARG E  213  GLY E  233  1                                  21    
HELIX  100 100 THR E  246  LEU E  260  1                                  15    
HELIX  101 101 PHE E  269  GLY E  288  1                                  20    
HELIX  102 102 MET E  297  ARG E  303  1                                   7    
HELIX  103 103 HIS E  310  GLY E  322  1                                  13    
HELIX  104 104 ASP E  338  GLU E  351  1                                  14    
HELIX  105 105 ARG E  358  GLY E  361  5                                   4    
HELIX  106 106 HIS E  383  TRP E  385  5                                   3    
HELIX  107 107 HIS E  386  GLY E  395  1                                  10    
HELIX  108 108 GLY E  403  GLY E  408  1                                   6    
HELIX  109 109 GLY E  412  GLY E  434  1                                  23    
HELIX  110 110 ASP E  436  LYS E  463  1                                  28    
HELIX  111 111 TYR F   20  TYR F   25  1                                   6    
HELIX  112 112 PRO F   49  SER F   61  1                                  13    
HELIX  113 113 VAL F   69  THR F   75  5                                   7    
HELIX  114 114 ASP F   76  LYS F   81  1                                   6    
HELIX  115 115 PRO F  104  PHE F  108  5                                   5    
HELIX  116 116 SER F  112  GLY F  122  1                                  11    
HELIX  117 117 ASN F  123  GLY F  126  5                                   4    
HELIX  118 118 PRO F  141  LYS F  146  1                                   6    
HELIX  119 119 GLY F  154  ASN F  163  1                                  10    
HELIX  120 120 SER F  181  GLY F  195  1                                  15    
HELIX  121 121 ARG F  213  GLY F  233  1                                  21    
HELIX  122 122 THR F  246  LEU F  260  1                                  15    
HELIX  123 123 PHE F  269  GLY F  288  1                                  20    
HELIX  124 124 MET F  297  ARG F  303  1                                   7    
HELIX  125 125 HIS F  310  GLY F  322  1                                  13    
HELIX  126 126 ASP F  338  GLU F  351  1                                  14    
HELIX  127 127 ARG F  358  GLY F  361  5                                   4    
HELIX  128 128 HIS F  383  TRP F  385  5                                   3    
HELIX  129 129 HIS F  386  GLY F  395  1                                  10    
HELIX  130 130 GLY F  403  GLY F  408  1                                   6    
HELIX  131 131 GLY F  412  GLY F  434  1                                  23    
HELIX  132 132 ASP F  436  LYS F  463  1                                  28    
HELIX  133 133 TYR G   20  TYR G   25  1                                   6    
HELIX  134 134 PRO G   49  SER G   61  1                                  13    
HELIX  135 135 VAL G   69  THR G   75  5                                   7    
HELIX  136 136 ASP G   76  LYS G   81  1                                   6    
HELIX  137 137 PRO G  104  PHE G  108  5                                   5    
HELIX  138 138 SER G  112  GLY G  122  1                                  11    
HELIX  139 139 ASN G  123  GLY G  126  5                                   4    
HELIX  140 140 PRO G  141  LYS G  146  1                                   6    
HELIX  141 141 GLY G  154  ASN G  163  1                                  10    
HELIX  142 142 SER G  181  GLY G  195  1                                  15    
HELIX  143 143 ARG G  213  GLY G  233  1                                  21    
HELIX  144 144 THR G  246  LEU G  260  1                                  15    
HELIX  145 145 PHE G  269  GLY G  288  1                                  20    
HELIX  146 146 MET G  297  ARG G  303  1                                   7    
HELIX  147 147 HIS G  310  GLY G  322  1                                  13    
HELIX  148 148 ASP G  338  GLU G  351  1                                  14    
HELIX  149 149 ARG G  358  GLY G  361  5                                   4    
HELIX  150 150 HIS G  383  TRP G  385  5                                   3    
HELIX  151 151 HIS G  386  GLY G  395  1                                  10    
HELIX  152 152 GLY G  403  GLY G  408  1                                   6    
HELIX  153 153 GLY G  412  GLY G  434  1                                  23    
HELIX  154 154 ASP G  436  LYS G  463  1                                  28    
HELIX  155 155 TYR H   20  TYR H   25  1                                   6    
HELIX  156 156 PRO H   49  SER H   61  1                                  13    
HELIX  157 157 VAL H   69  THR H   75  5                                   7    
HELIX  158 158 ASP H   76  LYS H   81  1                                   6    
HELIX  159 159 PRO H  104  PHE H  108  5                                   5    
HELIX  160 160 SER H  112  GLY H  122  1                                  11    
HELIX  161 161 ASN H  123  GLY H  126  5                                   4    
HELIX  162 162 PRO H  141  LYS H  146  1                                   6    
HELIX  163 163 GLY H  154  ASN H  163  1                                  10    
HELIX  164 164 SER H  181  GLY H  195  1                                  15    
HELIX  165 165 ARG H  213  GLY H  233  1                                  21    
HELIX  166 166 THR H  246  LEU H  260  1                                  15    
HELIX  167 167 PHE H  269  GLY H  288  1                                  20    
HELIX  168 168 MET H  297  ARG H  303  1                                   7    
HELIX  169 169 HIS H  310  GLY H  322  1                                  13    
HELIX  170 170 ASP H  338  GLU H  351  1                                  14    
HELIX  171 171 ARG H  358  GLY H  361  5                                   4    
HELIX  172 172 HIS H  383  TRP H  385  5                                   3    
HELIX  173 173 HIS H  386  GLY H  395  1                                  10    
HELIX  174 174 GLY H  403  GLY H  408  1                                   6    
HELIX  175 175 GLY H  412  GLY H  434  1                                  23    
HELIX  176 176 ASP H  436  LYS H  463  1                                  28    
HELIX  177 177 ASN I    2  ASN I   34  1                                  33    
HELIX  178 178 ASN I   34  ALA I   46  1                                  13    
HELIX  179 179 ASP I   51  LYS I   63  1                                  13    
HELIX  180 180 LYS I   63  ALA I   82  1                                  20    
HELIX  181 181 PHE I   84  HIS I  104  1                                  21    
HELIX  182 182 ASN J    2  ASN J   34  1                                  33    
HELIX  183 183 ASN J   34  ALA J   46  1                                  13    
HELIX  184 184 ASP J   51  LYS J   63  1                                  13    
HELIX  185 185 LYS J   63  ALA J   82  1                                  20    
HELIX  186 186 PHE J   84  HIS J  104  1                                  21    
HELIX  187 187 ASN K    2  ASN K   34  1                                  33    
HELIX  188 188 ASN K   34  ALA K   46  1                                  13    
HELIX  189 189 ASP K   51  LYS K   63  1                                  13    
HELIX  190 190 LYS K   63  ALA K   82  1                                  20    
HELIX  191 191 PHE K   84  HIS K  104  1                                  21    
HELIX  192 192 ASN L    2  ASN L   34  1                                  33    
HELIX  193 193 ASN L   34  ALA L   46  1                                  13    
HELIX  194 194 ASP L   51  LYS L   63  1                                  13    
HELIX  195 195 LYS L   63  ALA L   82  1                                  20    
HELIX  196 196 PHE L   84  HIS L  104  1                                  21    
HELIX  197 197 ASN M    2  ASN M   34  1                                  33    
HELIX  198 198 ASN M   34  ALA M   46  1                                  13    
HELIX  199 199 ASP M   51  LYS M   63  1                                  13    
HELIX  200 200 LYS M   63  ALA M   82  1                                  20    
HELIX  201 201 PHE M   84  HIS M  104  1                                  21    
HELIX  202 202 ASN N    2  ASN N   34  1                                  33    
HELIX  203 203 ASN N   34  ALA N   46  1                                  13    
HELIX  204 204 ASP N   51  LYS N   63  1                                  13    
HELIX  205 205 LYS N   63  ALA N   82  1                                  20    
HELIX  206 206 PHE N   84  HIS N  104  1                                  21    
HELIX  207 207 ASN O    2  ASN O   34  1                                  33    
HELIX  208 208 ASN O   34  ALA O   46  1                                  13    
HELIX  209 209 ASP O   51  LYS O   63  1                                  13    
HELIX  210 210 LYS O   63  ALA O   82  1                                  20    
HELIX  211 211 PHE O   84  HIS O  104  1                                  21    
HELIX  212 212 ASN P    2  ASN P   34  1                                  33    
HELIX  213 213 ASN P   34  ALA P   46  1                                  13    
HELIX  214 214 ASP P   51  LYS P   63  1                                  13    
HELIX  215 215 LYS P   63  ALA P   82  1                                  20    
HELIX  216 216 PHE P   84  HIS P  104  1                                  21    
HELIX  217 217 ASN Q    2  ASN Q   34  1                                  33    
HELIX  218 218 ASN Q   34  ALA Q   46  1                                  13    
HELIX  219 219 ASP Q   51  LYS Q   63  1                                  13    
HELIX  220 220 LYS Q   63  ALA Q   82  1                                  20    
HELIX  221 221 PHE Q   84  HIS Q  104  1                                  21    
HELIX  222 222 ASN R    2  ASN R   34  1                                  33    
HELIX  223 223 ASN R   34  ALA R   46  1                                  13    
HELIX  224 224 ASP R   51  LYS R   63  1                                  13    
HELIX  225 225 LYS R   63  ALA R   82  1                                  20    
HELIX  226 226 PHE R   84  HIS R  104  1                                  21    
HELIX  227 227 ASN S    2  ASN S   34  1                                  33    
HELIX  228 228 ASN S   34  ALA S   46  1                                  13    
HELIX  229 229 ASP S   51  LYS S   63  1                                  13    
HELIX  230 230 LYS S   63  ALA S   82  1                                  20    
HELIX  231 231 PHE S   84  HIS S  104  1                                  21    
HELIX  232 232 ASN T    2  ASN T   34  1                                  33    
HELIX  233 233 ASN T   34  ALA T   46  1                                  13    
HELIX  234 234 ASP T   51  LYS T   63  1                                  13    
HELIX  235 235 LYS T   63  ALA T   82  1                                  20    
HELIX  236 236 PHE T   84  HIS T  104  1                                  21    
HELIX  237 237 ASN U    2  ASN U   34  1                                  33    
HELIX  238 238 ASN U   34  ALA U   46  1                                  13    
HELIX  239 239 ASP U   51  LYS U   63  1                                  13    
HELIX  240 240 LYS U   63  ALA U   82  1                                  20    
HELIX  241 241 PHE U   84  HIS U  104  1                                  21    
HELIX  242 242 ASN V    2  ASN V   34  1                                  33    
HELIX  243 243 ASN V   34  ALA V   46  1                                  13    
HELIX  244 244 ASP V   51  LYS V   63  1                                  13    
HELIX  245 245 LYS V   63  ALA V   82  1                                  20    
HELIX  246 246 PHE V   84  HIS V  104  1                                  21    
HELIX  247 247 ASN W    2  ASN W   34  1                                  33    
HELIX  248 248 ASN W   34  ALA W   46  1                                  13    
HELIX  249 249 ASP W   51  LYS W   63  1                                  13    
HELIX  250 250 LYS W   63  ALA W   82  1                                  20    
HELIX  251 251 PHE W   84  HIS W  104  1                                  21    
HELIX  252 252 ASN X    2  ASN X   34  1                                  33    
HELIX  253 253 ASN X   34  ALA X   46  1                                  13    
HELIX  254 254 ASP X   51  LYS X   63  1                                  13    
HELIX  255 255 LYS X   63  ALA X   82  1                                  20    
HELIX  256 256 PHE X   84  HIS X  104  1                                  21    
SHEET    1  AA 5 LYS A  83  PRO A  89  0                                        
SHEET    2  AA 5 TYR A  97  TYR A 103 -1  O  PHE A  98   N  GLU A  88           
SHEET    3  AA 5 LEU A  36  PRO A  44 -1  O  LEU A  36   N  TYR A 103           
SHEET    4  AA 5 ILE A 130  ARG A 139 -1  N  ARG A 131   O  SER A  43           
SHEET    5  AA 5 GLY A 308  ILE A 309  1  O  GLY A 308   N  LEU A 135           
SHEET    1  AB 8 MET A 169  GLY A 171  0                                        
SHEET    2  AB 8 VAL A 399  GLN A 401  1  O  LEU A 400   N  GLY A 171           
SHEET    3  AB 8 LEU A 375  SER A 379  1  O  PRO A 376   N  VAL A 399           
SHEET    4  AB 8 HIS A 325  HIS A 327  1  O  LEU A 326   N  VAL A 377           
SHEET    5  AB 8 LEU A 290  HIS A 294  1  O  ILE A 293   N  HIS A 327           
SHEET    6  AB 8 ILE A 264  ASP A 268  1  O  ILE A 265   N  HIS A 292           
SHEET    7  AB 8 GLY A 237  ASN A 241  1  O  LEU A 240   N  MET A 266           
SHEET    8  AB 8 PHE A 199  LYS A 201  1  O  THR A 200   N  TYR A 239           
SHEET    1  AC 2 HIS A 353  ILE A 354  0                                        
SHEET    2  AC 2 GLN A 366  ASP A 367 -1  O  GLN A 366   N  ILE A 354           
SHEET    1  BA 5 LYS B  83  PRO B  89  0                                        
SHEET    2  BA 5 TYR B  97  TYR B 103 -1  O  PHE B  98   N  GLU B  88           
SHEET    3  BA 5 LEU B  36  PRO B  44 -1  O  LEU B  36   N  TYR B 103           
SHEET    4  BA 5 ILE B 130  ARG B 139 -1  N  ARG B 131   O  SER B  43           
SHEET    5  BA 5 GLY B 308  ILE B 309  1  O  GLY B 308   N  LEU B 135           
SHEET    1  BB 8 MET B 169  GLY B 171  0                                        
SHEET    2  BB 8 VAL B 399  GLN B 401  1  O  LEU B 400   N  GLY B 171           
SHEET    3  BB 8 LEU B 375  SER B 379  1  O  PRO B 376   N  VAL B 399           
SHEET    4  BB 8 HIS B 325  HIS B 327  1  O  LEU B 326   N  VAL B 377           
SHEET    5  BB 8 LEU B 290  HIS B 294  1  O  ILE B 293   N  HIS B 327           
SHEET    6  BB 8 ILE B 264  ASP B 268  1  O  ILE B 265   N  HIS B 292           
SHEET    7  BB 8 GLY B 237  ASN B 241  1  O  LEU B 240   N  MET B 266           
SHEET    8  BB 8 PHE B 199  LYS B 201  1  O  THR B 200   N  TYR B 239           
SHEET    1  BC 2 HIS B 353  ILE B 354  0                                        
SHEET    2  BC 2 GLN B 366  ASP B 367 -1  O  GLN B 366   N  ILE B 354           
SHEET    1  CA 5 LYS C  83  PRO C  89  0                                        
SHEET    2  CA 5 TYR C  97  TYR C 103 -1  O  PHE C  98   N  GLU C  88           
SHEET    3  CA 5 LEU C  36  PRO C  44 -1  O  LEU C  36   N  TYR C 103           
SHEET    4  CA 5 ILE C 130  ARG C 139 -1  N  ARG C 131   O  SER C  43           
SHEET    5  CA 5 GLY C 308  ILE C 309  1  O  GLY C 308   N  LEU C 135           
SHEET    1  CB 8 MET C 169  GLY C 171  0                                        
SHEET    2  CB 8 VAL C 399  GLN C 401  1  O  LEU C 400   N  GLY C 171           
SHEET    3  CB 8 LEU C 375  SER C 379  1  O  PRO C 376   N  VAL C 399           
SHEET    4  CB 8 HIS C 325  HIS C 327  1  O  LEU C 326   N  VAL C 377           
SHEET    5  CB 8 LEU C 290  HIS C 294  1  O  ILE C 293   N  HIS C 327           
SHEET    6  CB 8 ILE C 264  ASP C 268  1  O  ILE C 265   N  HIS C 292           
SHEET    7  CB 8 GLY C 237  ASN C 241  1  O  LEU C 240   N  MET C 266           
SHEET    8  CB 8 PHE C 199  LYS C 201  1  O  THR C 200   N  TYR C 239           
SHEET    1  CC 2 HIS C 353  ILE C 354  0                                        
SHEET    2  CC 2 GLN C 366  ASP C 367 -1  O  GLN C 366   N  ILE C 354           
SHEET    1  DA 5 LYS D  83  PRO D  89  0                                        
SHEET    2  DA 5 TYR D  97  TYR D 103 -1  O  PHE D  98   N  GLU D  88           
SHEET    3  DA 5 LEU D  36  PRO D  44 -1  O  LEU D  36   N  TYR D 103           
SHEET    4  DA 5 ILE D 130  ARG D 139 -1  N  ARG D 131   O  SER D  43           
SHEET    5  DA 5 GLY D 308  ILE D 309  1  O  GLY D 308   N  LEU D 135           
SHEET    1  DB 8 MET D 169  GLY D 171  0                                        
SHEET    2  DB 8 VAL D 399  GLN D 401  1  O  LEU D 400   N  GLY D 171           
SHEET    3  DB 8 LEU D 375  SER D 379  1  O  PRO D 376   N  VAL D 399           
SHEET    4  DB 8 HIS D 325  HIS D 327  1  O  LEU D 326   N  VAL D 377           
SHEET    5  DB 8 LEU D 290  HIS D 294  1  O  ILE D 293   N  HIS D 327           
SHEET    6  DB 8 ILE D 264  ASP D 268  1  O  ILE D 265   N  HIS D 292           
SHEET    7  DB 8 GLY D 237  ASN D 241  1  O  LEU D 240   N  MET D 266           
SHEET    8  DB 8 PHE D 199  LYS D 201  1  O  THR D 200   N  TYR D 239           
SHEET    1  DC 2 HIS D 353  ILE D 354  0                                        
SHEET    2  DC 2 GLN D 366  ASP D 367 -1  O  GLN D 366   N  ILE D 354           
SHEET    1  EA 5 LYS E  83  PRO E  89  0                                        
SHEET    2  EA 5 TYR E  97  TYR E 103 -1  O  PHE E  98   N  GLU E  88           
SHEET    3  EA 5 LEU E  36  PRO E  44 -1  O  LEU E  36   N  TYR E 103           
SHEET    4  EA 5 ILE E 130  ARG E 139 -1  N  ARG E 131   O  SER E  43           
SHEET    5  EA 5 GLY E 308  ILE E 309  1  O  GLY E 308   N  LEU E 135           
SHEET    1  EB 8 MET E 169  GLY E 171  0                                        
SHEET    2  EB 8 VAL E 399  GLN E 401  1  O  LEU E 400   N  GLY E 171           
SHEET    3  EB 8 LEU E 375  SER E 379  1  O  PRO E 376   N  VAL E 399           
SHEET    4  EB 8 HIS E 325  HIS E 327  1  O  LEU E 326   N  VAL E 377           
SHEET    5  EB 8 LEU E 290  HIS E 294  1  O  ILE E 293   N  HIS E 327           
SHEET    6  EB 8 ILE E 264  ASP E 268  1  O  ILE E 265   N  HIS E 292           
SHEET    7  EB 8 GLY E 237  ASN E 241  1  O  LEU E 240   N  MET E 266           
SHEET    8  EB 8 PHE E 199  LYS E 201  1  O  THR E 200   N  TYR E 239           
SHEET    1  EC 2 HIS E 353  ILE E 354  0                                        
SHEET    2  EC 2 GLN E 366  ASP E 367 -1  O  GLN E 366   N  ILE E 354           
SHEET    1  FA 5 LYS F  83  PRO F  89  0                                        
SHEET    2  FA 5 TYR F  97  TYR F 103 -1  O  PHE F  98   N  GLU F  88           
SHEET    3  FA 5 LEU F  36  PRO F  44 -1  O  LEU F  36   N  TYR F 103           
SHEET    4  FA 5 ILE F 130  ARG F 139 -1  N  ARG F 131   O  SER F  43           
SHEET    5  FA 5 GLY F 308  ILE F 309  1  O  GLY F 308   N  LEU F 135           
SHEET    1  FB 8 MET F 169  GLY F 171  0                                        
SHEET    2  FB 8 VAL F 399  GLN F 401  1  O  LEU F 400   N  GLY F 171           
SHEET    3  FB 8 LEU F 375  SER F 379  1  O  PRO F 376   N  VAL F 399           
SHEET    4  FB 8 HIS F 325  HIS F 327  1  O  LEU F 326   N  VAL F 377           
SHEET    5  FB 8 LEU F 290  HIS F 294  1  O  ILE F 293   N  HIS F 327           
SHEET    6  FB 8 ILE F 264  ASP F 268  1  O  ILE F 265   N  HIS F 292           
SHEET    7  FB 8 GLY F 237  ASN F 241  1  O  LEU F 240   N  MET F 266           
SHEET    8  FB 8 PHE F 199  LYS F 201  1  O  THR F 200   N  TYR F 239           
SHEET    1  FC 2 HIS F 353  ILE F 354  0                                        
SHEET    2  FC 2 GLN F 366  ASP F 367 -1  O  GLN F 366   N  ILE F 354           
SHEET    1  GA 5 LYS G  83  PRO G  89  0                                        
SHEET    2  GA 5 TYR G  97  TYR G 103 -1  O  PHE G  98   N  GLU G  88           
SHEET    3  GA 5 LEU G  36  PRO G  44 -1  O  LEU G  36   N  TYR G 103           
SHEET    4  GA 5 ILE G 130  ARG G 139 -1  N  ARG G 131   O  SER G  43           
SHEET    5  GA 5 GLY G 308  ILE G 309  1  O  GLY G 308   N  LEU G 135           
SHEET    1  GB 8 MET G 169  GLY G 171  0                                        
SHEET    2  GB 8 VAL G 399  GLN G 401  1  O  LEU G 400   N  GLY G 171           
SHEET    3  GB 8 LEU G 375  SER G 379  1  O  PRO G 376   N  VAL G 399           
SHEET    4  GB 8 HIS G 325  HIS G 327  1  O  LEU G 326   N  VAL G 377           
SHEET    5  GB 8 LEU G 290  HIS G 294  1  O  ILE G 293   N  HIS G 327           
SHEET    6  GB 8 ILE G 264  ASP G 268  1  O  ILE G 265   N  HIS G 292           
SHEET    7  GB 8 GLY G 237  ASN G 241  1  O  LEU G 240   N  MET G 266           
SHEET    8  GB 8 PHE G 199  LYS G 201  1  O  THR G 200   N  TYR G 239           
SHEET    1  GC 2 HIS G 353  ILE G 354  0                                        
SHEET    2  GC 2 GLN G 366  ASP G 367 -1  O  GLN G 366   N  ILE G 354           
SHEET    1  HA 5 LYS H  83  PRO H  89  0                                        
SHEET    2  HA 5 TYR H  97  TYR H 103 -1  O  PHE H  98   N  GLU H  88           
SHEET    3  HA 5 LEU H  36  PRO H  44 -1  O  LEU H  36   N  TYR H 103           
SHEET    4  HA 5 ILE H 130  ARG H 139 -1  N  ARG H 131   O  SER H  43           
SHEET    5  HA 5 GLY H 308  ILE H 309  1  O  GLY H 308   N  LEU H 135           
SHEET    1  HB 8 MET H 169  GLY H 171  0                                        
SHEET    2  HB 8 VAL H 399  GLN H 401  1  O  LEU H 400   N  GLY H 171           
SHEET    3  HB 8 LEU H 375  SER H 379  1  O  PRO H 376   N  VAL H 399           
SHEET    4  HB 8 HIS H 325  HIS H 327  1  O  LEU H 326   N  VAL H 377           
SHEET    5  HB 8 LEU H 290  HIS H 294  1  O  ILE H 293   N  HIS H 327           
SHEET    6  HB 8 ILE H 264  ASP H 268  1  O  ILE H 265   N  HIS H 292           
SHEET    7  HB 8 GLY H 237  ASN H 241  1  O  LEU H 240   N  MET H 266           
SHEET    8  HB 8 PHE H 199  LYS H 201  1  O  THR H 200   N  TYR H 239           
SHEET    1  HC 2 HIS H 353  ILE H 354  0                                        
SHEET    2  HC 2 GLN H 366  ASP H 367 -1  O  GLN H 366   N  ILE H 354           
SSBOND   1 CYS A  247    CYS H  247                          1555   1555  2.22  
SSBOND   2 CYS B  247    CYS C  247                          1555   1555  2.18  
SSBOND   3 CYS D  247    CYS E  247                          1555   1555  2.17  
SSBOND   4 CYS F  247    CYS G  247                          1555   1555  2.17  
CISPEP   1 LYS A  175    PRO A  176          0        -4.12                     
CISPEP   2 LYS B  175    PRO B  176          0        -4.15                     
CISPEP   3 LYS C  175    PRO C  176          0        -4.08                     
CISPEP   4 LYS D  175    PRO D  176          0        -4.06                     
CISPEP   5 LYS E  175    PRO E  176          0        -4.13                     
CISPEP   6 LYS F  175    PRO F  176          0        -4.04                     
CISPEP   7 LYS G  175    PRO G  176          0        -4.24                     
CISPEP   8 LYS H  175    PRO H  176          0        -4.13                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1          16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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