HEADER TRANSFERASE 30-SEP-08 3EQL
TITLE CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN
TITLE 2 COMPLEX WITH ANTIBIOTIC MYXOPYRONIN
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA;
COMPND 3 CHAIN: A, B, K, L;
COMPND 4 SYNONYM: RNAP SUBUNIT ALPHA, TRANSCRIPTASE SUBUNIT ALPHA, RNA
COMPND 5 POLYMERASE SUBUNIT ALPHA;
COMPND 6 EC: 2.7.7.6;
COMPND 7 MOL_ID: 2;
COMPND 8 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;
COMPND 9 CHAIN: C, M;
COMPND 10 SYNONYM: RNAP SUBUNIT BETA, TRANSCRIPTASE SUBUNIT BETA, RNA
COMPND 11 POLYMERASE SUBUNIT BETA;
COMPND 12 EC: 2.7.7.6;
COMPND 13 MOL_ID: 3;
COMPND 14 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA';
COMPND 15 CHAIN: D, N;
COMPND 16 SYNONYM: RNAP SUBUNIT BETA', TRANSCRIPTASE SUBUNIT BETA', RNA
COMPND 17 POLYMERASE SUBUNIT BETA';
COMPND 18 EC: 2.7.7.6;
COMPND 19 MOL_ID: 4;
COMPND 20 MOLECULE: DNA-DIRECTED RNA POLYMERASE SUBUNIT OMEGA;
COMPND 21 CHAIN: E, O;
COMPND 22 SYNONYM: RNAP OMEGA SUBUNIT, TRANSCRIPTASE SUBUNIT OMEGA, RNA
COMPND 23 POLYMERASE OMEGA SUBUNIT;
COMPND 24 EC: 2.7.7.6;
COMPND 25 MOL_ID: 5;
COMPND 26 MOLECULE: RNA POLYMERASE SIGMA FACTOR RPOD;
COMPND 27 CHAIN: F, P
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: THERMUS THERMOPHILUS;
SOURCE 3 ORGANISM_TAXID: 274;
SOURCE 4 MOL_ID: 2;
SOURCE 5 ORGANISM_SCIENTIFIC: THERMUS THERMOPHILUS;
SOURCE 6 ORGANISM_TAXID: 274;
SOURCE 7 MOL_ID: 3;
SOURCE 8 ORGANISM_SCIENTIFIC: THERMUS THERMOPHILUS;
SOURCE 9 ORGANISM_TAXID: 274;
SOURCE 10 MOL_ID: 4;
SOURCE 11 ORGANISM_SCIENTIFIC: THERMUS THERMOPHILUS;
SOURCE 12 ORGANISM_TAXID: 274;
SOURCE 13 MOL_ID: 5;
SOURCE 14 ORGANISM_SCIENTIFIC: THERMUS THERMOPHILUS;
SOURCE 15 ORGANISM_TAXID: 274
KEYWDS RNA POLYMERASE HOLOENZYME, MYXOPYRONIN, ANTIBIOTIC, TRANSCRIPTION
KEYWDS 2 REGULATION, DNA-DIRECTED RNA POLYMERASE, NUCLEOTIDYLTRANSFERASE,
KEYWDS 3 TRANSCRIPTION, TRANSFERASE, DNA-BINDING, SIGMA FACTOR
EXPDTA X-RAY DIFFRACTION
AUTHOR D.G.VASSYLYEV,M.N.VASSYLYEVA,I.ARTSIMOVITCH
REVDAT 3 06-SEP-23 3EQL 1 REMARK
REVDAT 2 20-JAN-09 3EQL 1 JRNL VERSN
REVDAT 1 28-OCT-08 3EQL 0
JRNL AUTH G.A.BELOGUROV,M.N.VASSYLYEVA,A.SEVOSTYANOVA,J.R.APPLEMAN,
JRNL AUTH 2 A.X.XIANG,R.LIRA,S.E.WEBBER,S.KLYUYEV,E.NUDLER,
JRNL AUTH 3 I.ARTSIMOVITCH,D.G.VASSYLYEV
JRNL TITL TRANSCRIPTION INACTIVATION THROUGH LOCAL REFOLDING OF THE
JRNL TITL 2 RNA POLYMERASE STRUCTURE.
JRNL REF NATURE V. 457 332 2009
JRNL REFN ISSN 0028-0836
JRNL PMID 18946472
JRNL DOI 10.1038/NATURE07510
REMARK 2
REMARK 2 RESOLUTION. 2.70 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : CNS 1.1
REMARK 3 AUTHORS : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-
REMARK 3 : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,
REMARK 3 : READ,RICE,SIMONSON,WARREN
REMARK 3
REMARK 3 REFINEMENT TARGET : ENGH & HUBER
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 2.70
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 40.00
REMARK 3 DATA CUTOFF (SIGMA(F)) : 0.000
REMARK 3 DATA CUTOFF HIGH (ABS(F)) : 0.000
REMARK 3 DATA CUTOFF LOW (ABS(F)) : 0.0000
REMARK 3 COMPLETENESS (WORKING+TEST) (%) : 97.7
REMARK 3 NUMBER OF REFLECTIONS : 422394
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 CROSS-VALIDATION METHOD : NULL
REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM
REMARK 3 R VALUE (WORKING SET) : 0.240
REMARK 3 FREE R VALUE : 0.270
REMARK 3 FREE R VALUE TEST SET SIZE (%) : 4.300
REMARK 3 FREE R VALUE TEST SET COUNT : 18510
REMARK 3 ESTIMATED ERROR OF FREE R VALUE : NULL
REMARK 3
REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.
REMARK 3 TOTAL NUMBER OF BINS USED : NULL
REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 2.70
REMARK 3 BIN RESOLUTION RANGE LOW (A) : 2.80
REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 93.20
REMARK 3 REFLECTIONS IN BIN (WORKING SET) : 35085
REMARK 3 BIN R VALUE (WORKING SET) : 0.2990
REMARK 3 BIN FREE R VALUE : 0.3230
REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) : 4.00
REMARK 3 BIN FREE R VALUE TEST SET COUNT : 1718
REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK 3
REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK 3 PROTEIN ATOMS : 52778
REMARK 3 NUCLEIC ACID ATOMS : 0
REMARK 3 HETEROGEN ATOMS : 66
REMARK 3 SOLVENT ATOMS : 4496
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : NULL
REMARK 3 MEAN B VALUE (OVERALL, A**2) : 57.61
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : NULL
REMARK 3 B22 (A**2) : NULL
REMARK 3 B33 (A**2) : NULL
REMARK 3 B12 (A**2) : NULL
REMARK 3 B13 (A**2) : NULL
REMARK 3 B23 (A**2) : NULL
REMARK 3
REMARK 3 ESTIMATED COORDINATE ERROR.
REMARK 3 ESD FROM LUZZATI PLOT (A) : 0.37
REMARK 3 ESD FROM SIGMAA (A) : 0.42
REMARK 3 LOW RESOLUTION CUTOFF (A) : 5.00
REMARK 3
REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK 3 ESD FROM C-V LUZZATI PLOT (A) : 0.40
REMARK 3 ESD FROM C-V SIGMAA (A) : 0.44
REMARK 3
REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES.
REMARK 3 BOND LENGTHS (A) : 0.015
REMARK 3 BOND ANGLES (DEGREES) : 1.990
REMARK 3 DIHEDRAL ANGLES (DEGREES) : 24.73
REMARK 3 IMPROPER ANGLES (DEGREES) : 1.220
REMARK 3
REMARK 3 ISOTROPIC THERMAL MODEL : NULL
REMARK 3
REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA
REMARK 3 MAIN-CHAIN BOND (A**2) : NULL ; NULL
REMARK 3 MAIN-CHAIN ANGLE (A**2) : NULL ; NULL
REMARK 3 SIDE-CHAIN BOND (A**2) : NULL ; NULL
REMARK 3 SIDE-CHAIN ANGLE (A**2) : NULL ; NULL
REMARK 3
REMARK 3 BULK SOLVENT MODELING.
REMARK 3 METHOD USED : NULL
REMARK 3 KSOL : NULL
REMARK 3 BSOL : NULL
REMARK 3
REMARK 3 NCS MODEL : NULL
REMARK 3
REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT
REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL
REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL
REMARK 3
REMARK 3 PARAMETER FILE 1 : NULL
REMARK 3 TOPOLOGY FILE 1 : NULL
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: THE PERFECT MEROHEDRAL TWINNING WAS
REMARK 3 DETECTED IN THE CRYSTALS WITH THE TWINNING OPERATOR {-H,-K,L}.
REMARK 3 THE REFINEMENT STATISTICS PRESENTED FOR THIS ENTRY CORRESPONDS
REMARK 3 TO THE REFINEMENT CARRIED OUT USING THE TWINNING OPTION OF THE
REMARK 3 CNS PROGRAM. FOR THE DEPOSITION THE DIFFRACTION DATA WERE
REMARK 3 DETWINNED USING THE CNS PROGRAM. THEREFORE, SOME REFLECTIONS
REMARK 3 WERE LOST DUE TO THE DETWINNING PROCEDURE AND ARE MISSING IN THE
REMARK 3 DEPOSITED SF FILE, WHEREAS THE REFINEMENT STATISTICS CALCULATED
REMARK 3 BASED ON THE DETWINNED ATA MIGHT BE SLIGHTLY DIFFERENT FROM
REMARK 3 THOSE OBTAINED DURING THE "TWINNED" REFINEMENT INCLUDED IN THIS
REMARK 3 ENTRY. THE ZONAL SCALING CORRECTION (VASSYLYEV ET AL. NATURE,
REMARK 3 448, 2007) WAS APPLIED TO THE EXPERIMENTAL STRUCTURE FACTORS
REMARK 3 DEPOSITED WITH THIS ENTRY
REMARK 4
REMARK 4 3EQL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 16-OCT-08.
REMARK 100 THE DEPOSITION ID IS D_1000049652.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : 18-DEC-07
REMARK 200 TEMPERATURE (KELVIN) : 100.0
REMARK 200 PH : 6.50
REMARK 200 NUMBER OF CRYSTALS USED : 1
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : Y
REMARK 200 RADIATION SOURCE : APS
REMARK 200 BEAMLINE : 23-ID-B
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M
REMARK 200 WAVELENGTH OR RANGE (A) : 1.0
REMARK 200 MONOCHROMATOR : GRAPHITE
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : IMAGE PLATE
REMARK 200 DETECTOR MANUFACTURER : MAR SCANNER 300 MM PLATE
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200 DATA SCALING SOFTWARE : HKL-2000
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 422394
REMARK 200 RESOLUTION RANGE HIGH (A) : 2.700
REMARK 200 RESOLUTION RANGE LOW (A) : 40.000
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : 0.000
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : 97.7
REMARK 200 DATA REDUNDANCY : 5.180
REMARK 200 R MERGE (I) : 0.08400
REMARK 200 R SYM (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 14.3000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.70
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 2.80
REMARK 200 COMPLETENESS FOR SHELL (%) : 93.2
REMARK 200 DATA REDUNDANCY IN SHELL : 2.35
REMARK 200 R MERGE FOR SHELL (I) : 0.44400
REMARK 200 R SYM FOR SHELL (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR SHELL : 2.500
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: AMORE
REMARK 200 STARTING MODEL: PDB ENTRY 2BE5
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 75.00
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 5.20
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: MG FORMATE, PEG400, SPERMIDINE, TRIS
REMARK 280 HCL, PH 6.50, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 32
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290 2555 -Y,X-Y,Z+2/3
REMARK 290 3555 -X+Y,-X,Z+1/3
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290 SMTRY1 2 -0.500000 -0.866025 0.000000 0.00000
REMARK 290 SMTRY2 2 0.866025 -0.500000 0.000000 0.00000
REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 169.96467
REMARK 290 SMTRY1 3 -0.500000 0.866025 0.000000 0.00000
REMARK 290 SMTRY2 3 -0.866025 -0.500000 0.000000 0.00000
REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 84.98233
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: K, L, M, N, O, P
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 ALA A 230
REMARK 465 ALA A 231
REMARK 465 ALA A 232
REMARK 465 VAL A 233
REMARK 465 ALA A 234
REMARK 465 ALA A 235
REMARK 465 PRO A 236
REMARK 465 GLU A 237
REMARK 465 GLU A 238
REMARK 465 ALA A 239
REMARK 465 LYS A 240
REMARK 465 GLU A 241
REMARK 465 PRO A 242
REMARK 465 GLU A 243
REMARK 465 ALA A 244
REMARK 465 PRO A 245
REMARK 465 PRO A 246
REMARK 465 GLU A 247
REMARK 465 GLN A 248
REMARK 465 GLU A 249
REMARK 465 GLU A 250
REMARK 465 GLU A 251
REMARK 465 LEU A 252
REMARK 465 ASP A 253
REMARK 465 LEU A 254
REMARK 465 PRO A 255
REMARK 465 LEU A 256
REMARK 465 GLU A 257
REMARK 465 GLU A 258
REMARK 465 LEU A 259
REMARK 465 GLY A 260
REMARK 465 LEU A 261
REMARK 465 SER A 262
REMARK 465 THR A 263
REMARK 465 ARG A 264
REMARK 465 VAL A 265
REMARK 465 LEU A 266
REMARK 465 HIS A 267
REMARK 465 SER A 268
REMARK 465 LEU A 269
REMARK 465 LYS A 270
REMARK 465 GLU A 271
REMARK 465 GLU A 272
REMARK 465 GLY A 273
REMARK 465 ILE A 274
REMARK 465 GLU A 275
REMARK 465 SER A 276
REMARK 465 VAL A 277
REMARK 465 ARG A 278
REMARK 465 ALA A 279
REMARK 465 LEU A 280
REMARK 465 LEU A 281
REMARK 465 ALA A 282
REMARK 465 LEU A 283
REMARK 465 ASN A 284
REMARK 465 LEU A 285
REMARK 465 LYS A 286
REMARK 465 ASP A 287
REMARK 465 LEU A 288
REMARK 465 LYS A 289
REMARK 465 ASN A 290
REMARK 465 ILE A 291
REMARK 465 PRO A 292
REMARK 465 GLY A 293
REMARK 465 ILE A 294
REMARK 465 GLY A 295
REMARK 465 GLU A 296
REMARK 465 ARG A 297
REMARK 465 SER A 298
REMARK 465 LEU A 299
REMARK 465 GLU A 300
REMARK 465 GLU A 301
REMARK 465 ILE A 302
REMARK 465 LYS A 303
REMARK 465 GLU A 304
REMARK 465 ALA A 305
REMARK 465 LEU A 306
REMARK 465 GLU A 307
REMARK 465 LYS A 308
REMARK 465 LYS A 309
REMARK 465 GLY A 310
REMARK 465 PHE A 311
REMARK 465 THR A 312
REMARK 465 LEU A 313
REMARK 465 LYS A 314
REMARK 465 GLU A 315
REMARK 465 ALA B 230
REMARK 465 ALA B 231
REMARK 465 ALA B 232
REMARK 465 VAL B 233
REMARK 465 ALA B 234
REMARK 465 ALA B 235
REMARK 465 PRO B 236
REMARK 465 GLU B 237
REMARK 465 GLU B 238
REMARK 465 ALA B 239
REMARK 465 LYS B 240
REMARK 465 GLU B 241
REMARK 465 PRO B 242
REMARK 465 GLU B 243
REMARK 465 ALA B 244
REMARK 465 PRO B 245
REMARK 465 PRO B 246
REMARK 465 GLU B 247
REMARK 465 GLN B 248
REMARK 465 GLU B 249
REMARK 465 GLU B 250
REMARK 465 GLU B 251
REMARK 465 LEU B 252
REMARK 465 ASP B 253
REMARK 465 LEU B 254
REMARK 465 PRO B 255
REMARK 465 LEU B 256
REMARK 465 GLU B 257
REMARK 465 GLU B 258
REMARK 465 LEU B 259
REMARK 465 GLY B 260
REMARK 465 LEU B 261
REMARK 465 SER B 262
REMARK 465 THR B 263
REMARK 465 ARG B 264
REMARK 465 VAL B 265
REMARK 465 LEU B 266
REMARK 465 HIS B 267
REMARK 465 SER B 268
REMARK 465 LEU B 269
REMARK 465 LYS B 270
REMARK 465 GLU B 271
REMARK 465 GLU B 272
REMARK 465 GLY B 273
REMARK 465 ILE B 274
REMARK 465 GLU B 275
REMARK 465 SER B 276
REMARK 465 VAL B 277
REMARK 465 ARG B 278
REMARK 465 ALA B 279
REMARK 465 LEU B 280
REMARK 465 LEU B 281
REMARK 465 ALA B 282
REMARK 465 LEU B 283
REMARK 465 ASN B 284
REMARK 465 LEU B 285
REMARK 465 LYS B 286
REMARK 465 ASP B 287
REMARK 465 LEU B 288
REMARK 465 LYS B 289
REMARK 465 ASN B 290
REMARK 465 ILE B 291
REMARK 465 PRO B 292
REMARK 465 GLY B 293
REMARK 465 ILE B 294
REMARK 465 GLY B 295
REMARK 465 GLU B 296
REMARK 465 ARG B 297
REMARK 465 SER B 298
REMARK 465 LEU B 299
REMARK 465 GLU B 300
REMARK 465 GLU B 301
REMARK 465 ILE B 302
REMARK 465 LYS B 303
REMARK 465 GLU B 304
REMARK 465 ALA B 305
REMARK 465 LEU B 306
REMARK 465 GLU B 307
REMARK 465 LYS B 308
REMARK 465 LYS B 309
REMARK 465 GLY B 310
REMARK 465 PHE B 311
REMARK 465 THR B 312
REMARK 465 LEU B 313
REMARK 465 LYS B 314
REMARK 465 GLU B 315
REMARK 465 MET D 1
REMARK 465 PRO D 208
REMARK 465 ARG D 209
REMARK 465 ARG D 210
REMARK 465 VAL D 211
REMARK 465 ARG D 212
REMARK 465 VAL D 213
REMARK 465 GLU D 214
REMARK 465 TYR D 215
REMARK 465 VAL D 216
REMARK 465 LYS D 217
REMARK 465 LYS D 218
REMARK 465 GLU D 219
REMARK 465 ARG D 220
REMARK 465 ALA D 221
REMARK 465 GLY D 222
REMARK 465 LEU D 223
REMARK 465 ARG D 224
REMARK 465 LEU D 225
REMARK 465 PRO D 226
REMARK 465 LEU D 227
REMARK 465 ALA D 228
REMARK 465 ALA D 229
REMARK 465 TRP D 230
REMARK 465 VAL D 231
REMARK 465 GLU D 232
REMARK 465 LYS D 233
REMARK 465 GLU D 234
REMARK 465 ALA D 235
REMARK 465 TYR D 236
REMARK 465 LYS D 237
REMARK 465 PRO D 238
REMARK 465 GLY D 239
REMARK 465 GLU D 240
REMARK 465 ILE D 241
REMARK 465 LEU D 242
REMARK 465 ALA D 243
REMARK 465 GLU D 244
REMARK 465 LEU D 245
REMARK 465 PRO D 246
REMARK 465 GLU D 247
REMARK 465 PRO D 248
REMARK 465 TYR D 249
REMARK 465 LEU D 250
REMARK 465 PHE D 251
REMARK 465 ARG D 252
REMARK 465 ALA D 253
REMARK 465 GLU D 254
REMARK 465 GLU D 255
REMARK 465 GLU D 256
REMARK 465 GLY D 257
REMARK 465 VAL D 258
REMARK 465 VAL D 259
REMARK 465 GLU D 260
REMARK 465 LEU D 261
REMARK 465 LYS D 262
REMARK 465 GLU D 263
REMARK 465 LEU D 264
REMARK 465 GLU D 265
REMARK 465 GLU D 266
REMARK 465 GLY D 267
REMARK 465 ALA D 268
REMARK 465 PHE D 269
REMARK 465 LEU D 270
REMARK 465 VAL D 271
REMARK 465 LEU D 272
REMARK 465 ARG D 273
REMARK 465 ARG D 274
REMARK 465 GLU D 275
REMARK 465 ASP D 276
REMARK 465 GLU D 277
REMARK 465 PRO D 278
REMARK 465 VAL D 279
REMARK 465 ALA D 280
REMARK 465 THR D 281
REMARK 465 TYR D 282
REMARK 465 PHE D 283
REMARK 465 LEU D 284
REMARK 465 PRO D 285
REMARK 465 VAL D 286
REMARK 465 GLY D 287
REMARK 465 MET D 288
REMARK 465 THR D 289
REMARK 465 PRO D 290
REMARK 465 LEU D 291
REMARK 465 VAL D 292
REMARK 465 VAL D 293
REMARK 465 HIS D 294
REMARK 465 GLY D 295
REMARK 465 GLU D 296
REMARK 465 ILE D 297
REMARK 465 VAL D 298
REMARK 465 GLU D 299
REMARK 465 LYS D 300
REMARK 465 GLY D 301
REMARK 465 GLN D 302
REMARK 465 PRO D 303
REMARK 465 LEU D 304
REMARK 465 ALA D 305
REMARK 465 GLU D 306
REMARK 465 ALA D 307
REMARK 465 LYS D 308
REMARK 465 GLY D 309
REMARK 465 LEU D 310
REMARK 465 LEU D 311
REMARK 465 ARG D 312
REMARK 465 MET D 313
REMARK 465 PRO D 314
REMARK 465 ARG D 315
REMARK 465 GLN D 316
REMARK 465 VAL D 317
REMARK 465 ARG D 318
REMARK 465 ALA D 319
REMARK 465 ALA D 320
REMARK 465 GLN D 321
REMARK 465 VAL D 322
REMARK 465 GLU D 323
REMARK 465 ALA D 324
REMARK 465 GLU D 325
REMARK 465 GLU D 326
REMARK 465 GLU D 327
REMARK 465 GLY D 328
REMARK 465 GLU D 329
REMARK 465 THR D 330
REMARK 465 VAL D 331
REMARK 465 TYR D 332
REMARK 465 LEU D 333
REMARK 465 THR D 334
REMARK 465 LEU D 335
REMARK 465 PHE D 336
REMARK 465 LEU D 337
REMARK 465 GLU D 338
REMARK 465 TRP D 339
REMARK 465 THR D 340
REMARK 465 GLU D 341
REMARK 465 PRO D 342
REMARK 465 LYS D 343
REMARK 465 ASP D 344
REMARK 465 TYR D 345
REMARK 465 ARG D 346
REMARK 465 VAL D 347
REMARK 465 GLN D 348
REMARK 465 PRO D 349
REMARK 465 HIS D 350
REMARK 465 MET D 351
REMARK 465 ASN D 352
REMARK 465 VAL D 353
REMARK 465 VAL D 354
REMARK 465 VAL D 355
REMARK 465 PRO D 356
REMARK 465 GLU D 357
REMARK 465 GLY D 358
REMARK 465 ALA D 359
REMARK 465 ARG D 360
REMARK 465 VAL D 361
REMARK 465 GLU D 362
REMARK 465 ALA D 363
REMARK 465 GLY D 364
REMARK 465 ASP D 365
REMARK 465 LYS D 366
REMARK 465 ILE D 367
REMARK 465 VAL D 368
REMARK 465 ALA D 369
REMARK 465 ALA D 370
REMARK 465 ILE D 371
REMARK 465 ASP D 372
REMARK 465 PRO D 373
REMARK 465 GLU D 374
REMARK 465 GLU D 375
REMARK 465 GLU D 376
REMARK 465 VAL D 377
REMARK 465 ILE D 378
REMARK 465 ALA D 379
REMARK 465 GLU D 380
REMARK 465 ALA D 381
REMARK 465 GLU D 382
REMARK 465 GLY D 383
REMARK 465 VAL D 384
REMARK 465 VAL D 385
REMARK 465 HIS D 386
REMARK 465 LEU D 387
REMARK 465 HIS D 388
REMARK 465 GLU D 389
REMARK 465 PRO D 390
REMARK 465 LYS D 1506
REMARK 465 GLU D 1507
REMARK 465 ARG D 1508
REMARK 465 PRO D 1509
REMARK 465 ALA D 1510
REMARK 465 ALA D 1511
REMARK 465 ARG D 1512
REMARK 465 ARG D 1513
REMARK 465 GLY D 1514
REMARK 465 VAL D 1515
REMARK 465 LYS D 1516
REMARK 465 ARG D 1517
REMARK 465 GLU D 1518
REMARK 465 GLN D 1519
REMARK 465 PRO D 1520
REMARK 465 GLY D 1521
REMARK 465 LYS D 1522
REMARK 465 GLN D 1523
REMARK 465 ALA D 1524
REMARK 465 MET E 1
REMARK 465 ARG E 97
REMARK 465 GLU E 98
REMARK 465 GLU E 99
REMARK 465 MET F 1
REMARK 465 LYS F 2
REMARK 465 LYS F 3
REMARK 465 SER F 4
REMARK 465 LYS F 5
REMARK 465 ARG F 6
REMARK 465 LYS F 7
REMARK 465 ASN F 8
REMARK 465 ALA F 9
REMARK 465 GLN F 10
REMARK 465 ALA F 11
REMARK 465 GLN F 12
REMARK 465 GLU F 13
REMARK 465 ALA F 14
REMARK 465 GLN F 15
REMARK 465 GLU F 16
REMARK 465 THR F 17
REMARK 465 GLU F 18
REMARK 465 VAL F 19
REMARK 465 LEU F 20
REMARK 465 VAL F 21
REMARK 465 GLN F 22
REMARK 465 GLU F 23
REMARK 465 GLU F 24
REMARK 465 ALA F 25
REMARK 465 GLU F 26
REMARK 465 GLU F 27
REMARK 465 LEU F 28
REMARK 465 PRO F 29
REMARK 465 GLU F 30
REMARK 465 PHE F 31
REMARK 465 PRO F 32
REMARK 465 GLU F 33
REMARK 465 GLY F 34
REMARK 465 GLU F 35
REMARK 465 PRO F 36
REMARK 465 ASP F 37
REMARK 465 PRO F 38
REMARK 465 ASP F 39
REMARK 465 LEU F 40
REMARK 465 GLU F 41
REMARK 465 ASP F 42
REMARK 465 PRO F 43
REMARK 465 ASP F 44
REMARK 465 LEU F 45
REMARK 465 ALA F 46
REMARK 465 LEU F 47
REMARK 465 GLU F 48
REMARK 465 ASP F 49
REMARK 465 ASP F 50
REMARK 465 LEU F 51
REMARK 465 LEU F 52
REMARK 465 ASP F 53
REMARK 465 LEU F 54
REMARK 465 PRO F 55
REMARK 465 GLU F 56
REMARK 465 GLU F 57
REMARK 465 GLY F 58
REMARK 465 GLU F 59
REMARK 465 GLY F 60
REMARK 465 LEU F 61
REMARK 465 ASP F 62
REMARK 465 LEU F 63
REMARK 465 GLU F 64
REMARK 465 GLU F 65
REMARK 465 GLU F 66
REMARK 465 GLU F 67
REMARK 465 GLU F 68
REMARK 465 ASP F 69
REMARK 465 LEU F 70
REMARK 465 PRO F 71
REMARK 465 ILE F 72
REMARK 465 PRO F 73
REMARK 465 ARG F 379
REMARK 465 GLU F 380
REMARK 465 HIS F 381
REMARK 465 THR F 382
REMARK 465 LEU F 383
REMARK 465 ALA K 230
REMARK 465 ALA K 231
REMARK 465 ALA K 232
REMARK 465 VAL K 233
REMARK 465 ALA K 234
REMARK 465 ALA K 235
REMARK 465 PRO K 236
REMARK 465 GLU K 237
REMARK 465 GLU K 238
REMARK 465 ALA K 239
REMARK 465 LYS K 240
REMARK 465 GLU K 241
REMARK 465 PRO K 242
REMARK 465 GLU K 243
REMARK 465 ALA K 244
REMARK 465 PRO K 245
REMARK 465 PRO K 246
REMARK 465 GLU K 247
REMARK 465 GLN K 248
REMARK 465 GLU K 249
REMARK 465 GLU K 250
REMARK 465 GLU K 251
REMARK 465 LEU K 252
REMARK 465 ASP K 253
REMARK 465 LEU K 254
REMARK 465 PRO K 255
REMARK 465 LEU K 256
REMARK 465 GLU K 257
REMARK 465 GLU K 258
REMARK 465 LEU K 259
REMARK 465 GLY K 260
REMARK 465 LEU K 261
REMARK 465 SER K 262
REMARK 465 THR K 263
REMARK 465 ARG K 264
REMARK 465 VAL K 265
REMARK 465 LEU K 266
REMARK 465 HIS K 267
REMARK 465 SER K 268
REMARK 465 LEU K 269
REMARK 465 LYS K 270
REMARK 465 GLU K 271
REMARK 465 GLU K 272
REMARK 465 GLY K 273
REMARK 465 ILE K 274
REMARK 465 GLU K 275
REMARK 465 SER K 276
REMARK 465 VAL K 277
REMARK 465 ARG K 278
REMARK 465 ALA K 279
REMARK 465 LEU K 280
REMARK 465 LEU K 281
REMARK 465 ALA K 282
REMARK 465 LEU K 283
REMARK 465 ASN K 284
REMARK 465 LEU K 285
REMARK 465 LYS K 286
REMARK 465 ASP K 287
REMARK 465 LEU K 288
REMARK 465 LYS K 289
REMARK 465 ASN K 290
REMARK 465 ILE K 291
REMARK 465 PRO K 292
REMARK 465 GLY K 293
REMARK 465 ILE K 294
REMARK 465 GLY K 295
REMARK 465 GLU K 296
REMARK 465 ARG K 297
REMARK 465 SER K 298
REMARK 465 LEU K 299
REMARK 465 GLU K 300
REMARK 465 GLU K 301
REMARK 465 ILE K 302
REMARK 465 LYS K 303
REMARK 465 GLU K 304
REMARK 465 ALA K 305
REMARK 465 LEU K 306
REMARK 465 GLU K 307
REMARK 465 LYS K 308
REMARK 465 LYS K 309
REMARK 465 GLY K 310
REMARK 465 PHE K 311
REMARK 465 THR K 312
REMARK 465 LEU K 313
REMARK 465 LYS K 314
REMARK 465 GLU K 315
REMARK 465 ALA L 230
REMARK 465 ALA L 231
REMARK 465 ALA L 232
REMARK 465 VAL L 233
REMARK 465 ALA L 234
REMARK 465 ALA L 235
REMARK 465 PRO L 236
REMARK 465 GLU L 237
REMARK 465 GLU L 238
REMARK 465 ALA L 239
REMARK 465 LYS L 240
REMARK 465 GLU L 241
REMARK 465 PRO L 242
REMARK 465 GLU L 243
REMARK 465 ALA L 244
REMARK 465 PRO L 245
REMARK 465 PRO L 246
REMARK 465 GLU L 247
REMARK 465 GLN L 248
REMARK 465 GLU L 249
REMARK 465 GLU L 250
REMARK 465 GLU L 251
REMARK 465 LEU L 252
REMARK 465 ASP L 253
REMARK 465 LEU L 254
REMARK 465 PRO L 255
REMARK 465 LEU L 256
REMARK 465 GLU L 257
REMARK 465 GLU L 258
REMARK 465 LEU L 259
REMARK 465 GLY L 260
REMARK 465 LEU L 261
REMARK 465 SER L 262
REMARK 465 THR L 263
REMARK 465 ARG L 264
REMARK 465 VAL L 265
REMARK 465 LEU L 266
REMARK 465 HIS L 267
REMARK 465 SER L 268
REMARK 465 LEU L 269
REMARK 465 LYS L 270
REMARK 465 GLU L 271
REMARK 465 GLU L 272
REMARK 465 GLY L 273
REMARK 465 ILE L 274
REMARK 465 GLU L 275
REMARK 465 SER L 276
REMARK 465 VAL L 277
REMARK 465 ARG L 278
REMARK 465 ALA L 279
REMARK 465 LEU L 280
REMARK 465 LEU L 281
REMARK 465 ALA L 282
REMARK 465 LEU L 283
REMARK 465 ASN L 284
REMARK 465 LEU L 285
REMARK 465 LYS L 286
REMARK 465 ASP L 287
REMARK 465 LEU L 288
REMARK 465 LYS L 289
REMARK 465 ASN L 290
REMARK 465 ILE L 291
REMARK 465 PRO L 292
REMARK 465 GLY L 293
REMARK 465 ILE L 294
REMARK 465 GLY L 295
REMARK 465 GLU L 296
REMARK 465 ARG L 297
REMARK 465 SER L 298
REMARK 465 LEU L 299
REMARK 465 GLU L 300
REMARK 465 GLU L 301
REMARK 465 ILE L 302
REMARK 465 LYS L 303
REMARK 465 GLU L 304
REMARK 465 ALA L 305
REMARK 465 LEU L 306
REMARK 465 GLU L 307
REMARK 465 LYS L 308
REMARK 465 LYS L 309
REMARK 465 GLY L 310
REMARK 465 PHE L 311
REMARK 465 THR L 312
REMARK 465 LEU L 313
REMARK 465 LYS L 314
REMARK 465 GLU L 315
REMARK 465 MET N 1
REMARK 465 PRO N 208
REMARK 465 ARG N 209
REMARK 465 ARG N 210
REMARK 465 VAL N 211
REMARK 465 ARG N 212
REMARK 465 VAL N 213
REMARK 465 GLU N 214
REMARK 465 TYR N 215
REMARK 465 VAL N 216
REMARK 465 LYS N 217
REMARK 465 LYS N 218
REMARK 465 GLU N 219
REMARK 465 ARG N 220
REMARK 465 ALA N 221
REMARK 465 GLY N 222
REMARK 465 LEU N 223
REMARK 465 ARG N 224
REMARK 465 LEU N 225
REMARK 465 PRO N 226
REMARK 465 LEU N 227
REMARK 465 ALA N 228
REMARK 465 ALA N 229
REMARK 465 TRP N 230
REMARK 465 VAL N 231
REMARK 465 GLU N 232
REMARK 465 LYS N 233
REMARK 465 GLU N 234
REMARK 465 ALA N 235
REMARK 465 TYR N 236
REMARK 465 LYS N 237
REMARK 465 PRO N 238
REMARK 465 GLY N 239
REMARK 465 GLU N 240
REMARK 465 ILE N 241
REMARK 465 LEU N 242
REMARK 465 ALA N 243
REMARK 465 GLU N 244
REMARK 465 LEU N 245
REMARK 465 PRO N 246
REMARK 465 GLU N 247
REMARK 465 PRO N 248
REMARK 465 TYR N 249
REMARK 465 LEU N 250
REMARK 465 PHE N 251
REMARK 465 ARG N 252
REMARK 465 ALA N 253
REMARK 465 GLU N 254
REMARK 465 GLU N 255
REMARK 465 GLU N 256
REMARK 465 GLY N 257
REMARK 465 VAL N 258
REMARK 465 VAL N 259
REMARK 465 GLU N 260
REMARK 465 LEU N 261
REMARK 465 LYS N 262
REMARK 465 GLU N 263
REMARK 465 LEU N 264
REMARK 465 GLU N 265
REMARK 465 GLU N 266
REMARK 465 GLY N 267
REMARK 465 ALA N 268
REMARK 465 PHE N 269
REMARK 465 LEU N 270
REMARK 465 VAL N 271
REMARK 465 LEU N 272
REMARK 465 ARG N 273
REMARK 465 ARG N 274
REMARK 465 GLU N 275
REMARK 465 ASP N 276
REMARK 465 GLU N 277
REMARK 465 PRO N 278
REMARK 465 VAL N 279
REMARK 465 ALA N 280
REMARK 465 THR N 281
REMARK 465 TYR N 282
REMARK 465 PHE N 283
REMARK 465 LEU N 284
REMARK 465 PRO N 285
REMARK 465 VAL N 286
REMARK 465 GLY N 287
REMARK 465 MET N 288
REMARK 465 THR N 289
REMARK 465 PRO N 290
REMARK 465 LEU N 291
REMARK 465 VAL N 292
REMARK 465 VAL N 293
REMARK 465 HIS N 294
REMARK 465 GLY N 295
REMARK 465 GLU N 296
REMARK 465 ILE N 297
REMARK 465 VAL N 298
REMARK 465 GLU N 299
REMARK 465 LYS N 300
REMARK 465 GLY N 301
REMARK 465 GLN N 302
REMARK 465 PRO N 303
REMARK 465 LEU N 304
REMARK 465 ALA N 305
REMARK 465 GLU N 306
REMARK 465 ALA N 307
REMARK 465 LYS N 308
REMARK 465 GLY N 309
REMARK 465 LEU N 310
REMARK 465 LEU N 311
REMARK 465 ARG N 312
REMARK 465 MET N 313
REMARK 465 PRO N 314
REMARK 465 ARG N 315
REMARK 465 GLN N 316
REMARK 465 VAL N 317
REMARK 465 ARG N 318
REMARK 465 ALA N 319
REMARK 465 ALA N 320
REMARK 465 GLN N 321
REMARK 465 VAL N 322
REMARK 465 GLU N 323
REMARK 465 ALA N 324
REMARK 465 GLU N 325
REMARK 465 GLU N 326
REMARK 465 GLU N 327
REMARK 465 GLY N 328
REMARK 465 GLU N 329
REMARK 465 THR N 330
REMARK 465 VAL N 331
REMARK 465 TYR N 332
REMARK 465 LEU N 333
REMARK 465 THR N 334
REMARK 465 LEU N 335
REMARK 465 PHE N 336
REMARK 465 LEU N 337
REMARK 465 GLU N 338
REMARK 465 TRP N 339
REMARK 465 THR N 340
REMARK 465 GLU N 341
REMARK 465 PRO N 342
REMARK 465 LYS N 343
REMARK 465 ASP N 344
REMARK 465 TYR N 345
REMARK 465 ARG N 346
REMARK 465 VAL N 347
REMARK 465 GLN N 348
REMARK 465 PRO N 349
REMARK 465 HIS N 350
REMARK 465 MET N 351
REMARK 465 ASN N 352
REMARK 465 VAL N 353
REMARK 465 VAL N 354
REMARK 465 VAL N 355
REMARK 465 PRO N 356
REMARK 465 GLU N 357
REMARK 465 GLY N 358
REMARK 465 ALA N 359
REMARK 465 ARG N 360
REMARK 465 VAL N 361
REMARK 465 GLU N 362
REMARK 465 ALA N 363
REMARK 465 GLY N 364
REMARK 465 ASP N 365
REMARK 465 LYS N 366
REMARK 465 ILE N 367
REMARK 465 VAL N 368
REMARK 465 ALA N 369
REMARK 465 ALA N 370
REMARK 465 ILE N 371
REMARK 465 ASP N 372
REMARK 465 PRO N 373
REMARK 465 GLU N 374
REMARK 465 GLU N 375
REMARK 465 GLU N 376
REMARK 465 VAL N 377
REMARK 465 ILE N 378
REMARK 465 ALA N 379
REMARK 465 GLU N 380
REMARK 465 ALA N 381
REMARK 465 GLU N 382
REMARK 465 GLY N 383
REMARK 465 VAL N 384
REMARK 465 VAL N 385
REMARK 465 HIS N 386
REMARK 465 LEU N 387
REMARK 465 HIS N 388
REMARK 465 GLU N 389
REMARK 465 PRO N 390
REMARK 465 LYS N 1506
REMARK 465 GLU N 1507
REMARK 465 ARG N 1508
REMARK 465 PRO N 1509
REMARK 465 ALA N 1510
REMARK 465 ALA N 1511
REMARK 465 ARG N 1512
REMARK 465 ARG N 1513
REMARK 465 GLY N 1514
REMARK 465 VAL N 1515
REMARK 465 LYS N 1516
REMARK 465 ARG N 1517
REMARK 465 GLU N 1518
REMARK 465 GLN N 1519
REMARK 465 PRO N 1520
REMARK 465 GLY N 1521
REMARK 465 LYS N 1522
REMARK 465 GLN N 1523
REMARK 465 ALA N 1524
REMARK 465 MET O 1
REMARK 465 ARG O 97
REMARK 465 GLU O 98
REMARK 465 GLU O 99
REMARK 465 MET P 1
REMARK 465 LYS P 2
REMARK 465 LYS P 3
REMARK 465 SER P 4
REMARK 465 LYS P 5
REMARK 465 ARG P 6
REMARK 465 LYS P 7
REMARK 465 ASN P 8
REMARK 465 ALA P 9
REMARK 465 GLN P 10
REMARK 465 ALA P 11
REMARK 465 GLN P 12
REMARK 465 GLU P 13
REMARK 465 ALA P 14
REMARK 465 GLN P 15
REMARK 465 GLU P 16
REMARK 465 THR P 17
REMARK 465 GLU P 18
REMARK 465 VAL P 19
REMARK 465 LEU P 20
REMARK 465 VAL P 21
REMARK 465 GLN P 22
REMARK 465 GLU P 23
REMARK 465 GLU P 24
REMARK 465 ALA P 25
REMARK 465 GLU P 26
REMARK 465 GLU P 27
REMARK 465 LEU P 28
REMARK 465 PRO P 29
REMARK 465 GLU P 30
REMARK 465 PHE P 31
REMARK 465 PRO P 32
REMARK 465 GLU P 33
REMARK 465 GLY P 34
REMARK 465 GLU P 35
REMARK 465 PRO P 36
REMARK 465 ASP P 37
REMARK 465 PRO P 38
REMARK 465 ASP P 39
REMARK 465 LEU P 40
REMARK 465 GLU P 41
REMARK 465 ASP P 42
REMARK 465 PRO P 43
REMARK 465 ASP P 44
REMARK 465 LEU P 45
REMARK 465 ALA P 46
REMARK 465 LEU P 47
REMARK 465 GLU P 48
REMARK 465 ASP P 49
REMARK 465 ASP P 50
REMARK 465 LEU P 51
REMARK 465 LEU P 52
REMARK 465 ASP P 53
REMARK 465 LEU P 54
REMARK 465 PRO P 55
REMARK 465 GLU P 56
REMARK 465 GLU P 57
REMARK 465 GLY P 58
REMARK 465 GLU P 59
REMARK 465 GLY P 60
REMARK 465 LEU P 61
REMARK 465 ASP P 62
REMARK 465 LEU P 63
REMARK 465 GLU P 64
REMARK 465 GLU P 65
REMARK 465 GLU P 66
REMARK 465 GLU P 67
REMARK 465 GLU P 68
REMARK 465 ASP P 69
REMARK 465 LEU P 70
REMARK 465 PRO P 71
REMARK 465 ILE P 72
REMARK 465 PRO P 73
REMARK 465 ARG P 379
REMARK 465 GLU P 380
REMARK 465 HIS P 381
REMARK 465 THR P 382
REMARK 465 LEU P 383
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 GLU F 384 CG CD OE1 OE2
REMARK 470 GLU F 385 CG CD OE1 OE2
REMARK 470 VAL F 386 CG1 CG2
REMARK 470 PHE F 389 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE F 390 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLU P 384 CG CD OE1 OE2
REMARK 470 GLU P 385 CG CD OE1 OE2
REMARK 470 VAL P 386 CG1 CG2
REMARK 470 PHE P 389 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE P 390 CG CD1 CD2 CE1 CE2 CZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 O GLN N 611 O SER N 1439 2.09
REMARK 500 O ARG D 615 N ASN D 617 2.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 GLU A 26 C GLU A 26 O -0.210
REMARK 500 GLU B 26 C GLU B 26 O -0.194
REMARK 500 GLU K 26 C GLU K 26 O -0.201
REMARK 500 GLU L 26 C GLU L 26 O -0.187
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 GLU A 26 CA - C - O ANGL. DEV. = -17.2 DEGREES
REMARK 500 GLU A 26 CA - C - N ANGL. DEV. = 25.2 DEGREES
REMARK 500 PRO A 27 C - N - CA ANGL. DEV. = -13.3 DEGREES
REMARK 500 ARG A 42 NE - CZ - NH1 ANGL. DEV. = -3.9 DEGREES
REMARK 500 ILE A 158 CG1 - CB - CG2 ANGL. DEV. = -18.0 DEGREES
REMARK 500 LEU A 192 CA - CB - CG ANGL. DEV. = 15.9 DEGREES
REMARK 500 LEU A 197 CA - CB - CG ANGL. DEV. = 14.9 DEGREES
REMARK 500 LEU B 25 CA - CB - CG ANGL. DEV. = 16.9 DEGREES
REMARK 500 GLU B 26 CA - C - N ANGL. DEV. = 17.4 DEGREES
REMARK 500 LEU B 138 CA - CB - CG ANGL. DEV. = 28.5 DEGREES
REMARK 500 LEU B 138 CB - CG - CD1 ANGL. DEV. = -10.2 DEGREES
REMARK 500 ILE B 158 CB - CA - C ANGL. DEV. = -13.3 DEGREES
REMARK 500 PHE C 114 CB - CG - CD1 ANGL. DEV. = 4.3 DEGREES
REMARK 500 PRO C 178 C - N - CA ANGL. DEV. = 11.8 DEGREES
REMARK 500 PRO C 244 C - N - CD ANGL. DEV. = -16.1 DEGREES
REMARK 500 PRO C1079 C - N - CA ANGL. DEV. = 10.3 DEGREES
REMARK 500 ARG C1119 CB - CA - C ANGL. DEV. = 12.3 DEGREES
REMARK 500 LEU D 171 CA - CB - CG ANGL. DEV. = 14.2 DEGREES
REMARK 500 LEU D 581 CA - CB - CG ANGL. DEV. = 14.7 DEGREES
REMARK 500 PHE D 614 CA - CB - CG ANGL. DEV. = 18.1 DEGREES
REMARK 500 LEU D 637 CA - CB - CG ANGL. DEV. = 15.3 DEGREES
REMARK 500 GLU D1109 CA - C - N ANGL. DEV. = -13.9 DEGREES
REMARK 500 ALA D1110 C - N - CA ANGL. DEV. = 15.1 DEGREES
REMARK 500 TYR D1207 CA - CB - CG ANGL. DEV. = 12.1 DEGREES
REMARK 500 GLY D1411 N - CA - C ANGL. DEV. = -22.2 DEGREES
REMARK 500 PRO E 4 C - N - CA ANGL. DEV. = 9.4 DEGREES
REMARK 500 PRO E 94 C - N - CA ANGL. DEV. = 12.2 DEGREES
REMARK 500 PRO E 94 CA - N - CD ANGL. DEV. = -25.8 DEGREES
REMARK 500 PRO E 94 CA - CB - CG ANGL. DEV. = -13.1 DEGREES
REMARK 500 PRO E 94 N - CA - C ANGL. DEV. = 23.2 DEGREES
REMARK 500 LEU F 136 CA - CB - CG ANGL. DEV. = 15.6 DEGREES
REMARK 500 GLU K 26 CA - C - O ANGL. DEV. = -18.3 DEGREES
REMARK 500 GLU K 26 CA - C - N ANGL. DEV. = 26.6 DEGREES
REMARK 500 PRO K 27 C - N - CA ANGL. DEV. = -14.8 DEGREES
REMARK 500 ILE K 158 CG1 - CB - CG2 ANGL. DEV. = -17.8 DEGREES
REMARK 500 GLN K 188 CA - CB - CG ANGL. DEV. = -13.2 DEGREES
REMARK 500 LEU K 192 CA - CB - CG ANGL. DEV. = 18.0 DEGREES
REMARK 500 LEU L 25 CA - CB - CG ANGL. DEV. = 15.2 DEGREES
REMARK 500 GLU L 26 CA - C - O ANGL. DEV. = -13.2 DEGREES
REMARK 500 GLU L 26 CA - C - N ANGL. DEV. = 19.5 DEGREES
REMARK 500 LEU L 138 CA - CB - CG ANGL. DEV. = 28.0 DEGREES
REMARK 500 LEU L 138 CB - CG - CD1 ANGL. DEV. = -11.3 DEGREES
REMARK 500 ILE L 158 CB - CA - C ANGL. DEV. = -13.1 DEGREES
REMARK 500 PRO M 178 C - N - CA ANGL. DEV. = 11.7 DEGREES
REMARK 500 PRO M 244 C - N - CD ANGL. DEV. = -18.4 DEGREES
REMARK 500 PRO M1079 C - N - CA ANGL. DEV. = 10.3 DEGREES
REMARK 500 CYS N 58 CA - CB - SG ANGL. DEV. = 10.1 DEGREES
REMARK 500 CYS N 76 CA - CB - SG ANGL. DEV. = 8.3 DEGREES
REMARK 500 VAL N 80 CA - C - N ANGL. DEV. = -13.5 DEGREES
REMARK 500 THR N 81 C - N - CA ANGL. DEV. = 15.1 DEGREES
REMARK 500
REMARK 500 THIS ENTRY HAS 63 ANGLE DEVIATIONS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 ASP A 3 -77.71 -97.51
REMARK 500 LYS A 7 75.73 -69.30
REMARK 500 PRO A 9 107.92 -45.07
REMARK 500 GLU A 29 -100.37 -44.84
REMARK 500 PRO A 106 10.34 -64.76
REMARK 500 ASN A 124 53.92 -110.63
REMARK 500 ASP A 160 -73.64 -58.55
REMARK 500 ASP A 191 106.98 -56.35
REMARK 500 TYR A 224 4.50 -64.14
REMARK 500 ASP B 3 -80.72 -96.53
REMARK 500 PRO B 9 107.27 -44.29
REMARK 500 GLU B 29 -98.77 -46.66
REMARK 500 LEU B 36 -60.04 -94.18
REMARK 500 PRO B 106 8.56 -66.51
REMARK 500 ASN B 124 56.93 -110.17
REMARK 500 LEU B 138 101.98 -162.00
REMARK 500 HIS B 156 -71.48 -82.86
REMARK 500 ASP B 160 -74.33 -58.50
REMARK 500 PHE B 171 -63.40 -98.04
REMARK 500 ASP B 191 107.02 -55.59
REMARK 500 TYR B 224 5.77 -64.37
REMARK 500 PRO B 228 173.73 -59.55
REMARK 500 ARG C 10 101.35 -55.62
REMARK 500 PRO C 36 -0.77 -56.49
REMARK 500 GLU C 40 99.02 -48.74
REMARK 500 PRO C 53 80.17 -56.62
REMARK 500 GLU C 57 -73.58 -110.53
REMARK 500 LYS C 59 82.92 177.31
REMARK 500 LEU C 69 -71.53 -102.32
REMARK 500 TYR C 90 100.29 -57.47
REMARK 500 THR C 105 106.01 -54.30
REMARK 500 ASP C 111 -73.27 -27.41
REMARK 500 ILE C 129 -76.14 -89.51
REMARK 500 HIS C 141 -177.69 -175.71
REMARK 500 PRO C 150 177.60 -56.40
REMARK 500 PRO C 166 174.26 -48.02
REMARK 500 PRO C 170 163.78 -42.19
REMARK 500 GLU C 177 71.01 -117.07
REMARK 500 PRO C 178 -16.62 -30.65
REMARK 500 VAL C 186 -69.96 -98.92
REMARK 500 LYS C 188 -74.45 -164.44
REMARK 500 PRO C 231 -94.73 -55.95
REMARK 500 PRO C 244 -38.04 -131.37
REMARK 500 ARG C 250 72.15 -174.42
REMARK 500 ASP C 251 -75.79 -19.72
REMARK 500 ILE C 261 -87.32 -86.30
REMARK 500 ALA C 262 -96.49 -58.79
REMARK 500 ASP C 263 -70.08 -33.49
REMARK 500 PRO C 264 -174.76 -58.39
REMARK 500 ASP C 268 126.75 -25.04
REMARK 500
REMARK 500 THIS ENTRY HAS 509 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI RMS TYPE
REMARK 500 TYR N 132 0.07 SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN D1525 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS D 58 SG
REMARK 620 2 CYS D 60 SG 109.8
REMARK 620 3 CYS D 73 SG 111.6 107.0
REMARK 620 4 CYS D 76 SG 109.4 110.1 108.9
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG D1528 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP D 739 OD2
REMARK 620 2 ASP D 741 OD2 67.8
REMARK 620 3 ASP D 743 OD1 89.8 76.6
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN D1526 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS D1112 SG
REMARK 620 2 CYS D1194 SG 105.2
REMARK 620 3 CYS D1201 SG 104.1 117.5
REMARK 620 4 CYS D1204 SG 117.3 109.6 103.6
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN N1525 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS N 58 SG
REMARK 620 2 CYS N 60 SG 108.0
REMARK 620 3 CYS N 73 SG 110.6 109.2
REMARK 620 4 CYS N 76 SG 110.9 108.0 110.0
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG N1528 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ASP N 739 OD2
REMARK 620 2 ASP N 741 OD1 69.8
REMARK 620 3 ASP N 741 OD2 66.1 57.7
REMARK 620 4 ASP N 743 OD1 95.9 134.2 76.5
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN N1526 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS N1112 SG
REMARK 620 2 CYS N1194 SG 106.7
REMARK 620 3 CYS N1201 SG 103.8 115.4
REMARK 620 4 CYS N1204 SG 118.5 109.2 103.6
REMARK 620 N 1 2 3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN D1525
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN D1526
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MXP D1527
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG D1528
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN N1525
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN N1526
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MXP N1527
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG N1528
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 1IW7 RELATED DB: PDB
REMARK 900 RNAP HOLOENZYME
REMARK 900 RELATED ID: 1SMY RELATED DB: PDB
REMARK 900 RNAP HOLOENZYME IN NCOMPLEX WITH PPGPP
REMARK 900 RELATED ID: 2A6E RELATED DB: PDB
REMARK 900 RNAP HOLOENZYME (DIFFERENT CRYSTAL FORM)
REMARK 900 RELATED ID: 2A69 RELATED DB: PDB
REMARK 900 RNAP HOLOENZYME IN COMPLEX WITH RIFAPENTIN
REMARK 900 RELATED ID: 2A68 RELATED DB: PDB
REMARK 900 RNAP HOLOENZYME IN COMPLEX WITH RIFABUTIN
REMARK 900 RELATED ID: 2A6H RELATED DB: PDB
REMARK 900 RNAP HOLOENZYME IN COMPLEX WITH STREPTOLYDIGIN
REMARK 900 RELATED ID: 2BE5 RELATED DB: PDB
REMARK 900 RNAP HOLOENZYME IN COMPLEX WITH TAGETITOXIN
DBREF 3EQL A 1 315 UNP Q9Z9H6 RPOA_THETH 1 315
DBREF 3EQL B 1 315 UNP Q9Z9H6 RPOA_THETH 1 315
DBREF 3EQL C 1 1119 UNP Q8RQE9 RPOB_THET8 1 1119
DBREF 3EQL D 1 1524 UNP Q8RQE8 RPOC_THET8 1 1524
DBREF 3EQL E 1 99 UNP Q8RQE7 RPOZ_THET8 1 99
DBREF 3EQL F 1 423 UNP Q72L95 Q72L95_THET2 1 423
DBREF 3EQL K 1 315 UNP Q9Z9H6 RPOA_THETH 1 315
DBREF 3EQL L 1 315 UNP Q9Z9H6 RPOA_THETH 1 315
DBREF 3EQL M 1 1119 UNP Q8RQE9 RPOB_THET8 1 1119
DBREF 3EQL N 1 1524 UNP Q8RQE8 RPOC_THET8 1 1524
DBREF 3EQL O 1 99 UNP Q8RQE7 RPOZ_THET8 1 99
DBREF 3EQL P 1 423 UNP Q72L95 Q72L95_THET2 1 423
SEQRES 1 A 315 MET LEU ASP SER LYS LEU LYS ALA PRO VAL PHE THR VAL
SEQRES 2 A 315 ARG THR GLN GLY ARG GLU TYR GLY GLU PHE VAL LEU GLU
SEQRES 3 A 315 PRO LEU GLU ARG GLY PHE GLY VAL THR LEU GLY ASN PRO
SEQRES 4 A 315 LEU ARG ARG ILE LEU LEU SER SER ILE PRO GLY THR ALA
SEQRES 5 A 315 VAL THR SER VAL TYR ILE GLU ASP VAL LEU HIS GLU PHE
SEQRES 6 A 315 SER THR ILE PRO GLY VAL LYS GLU ASP VAL VAL GLU ILE
SEQRES 7 A 315 ILE LEU ASN LEU LYS GLU LEU VAL VAL ARG PHE LEU ASN
SEQRES 8 A 315 PRO SER LEU GLN THR VAL THR LEU LEU LEU LYS ALA GLU
SEQRES 9 A 315 GLY PRO LYS GLU VAL LYS ALA ARG ASP PHE LEU PRO VAL
SEQRES 10 A 315 ALA ASP VAL GLU ILE MET ASN PRO ASP LEU HIS ILE ALA
SEQRES 11 A 315 THR LEU GLU GLU GLY GLY ARG LEU ASN MET GLU VAL ARG
SEQRES 12 A 315 VAL ASP ARG GLY VAL GLY TYR VAL PRO ALA GLU LYS HIS
SEQRES 13 A 315 GLY ILE LYS ASP ARG ILE ASN ALA ILE PRO VAL ASP ALA
SEQRES 14 A 315 VAL PHE SER PRO VAL ARG ARG VAL ALA PHE GLN VAL GLU
SEQRES 15 A 315 ASP THR ARG LEU GLY GLN ARG THR ASP LEU ASP LYS LEU
SEQRES 16 A 315 THR LEU ARG ILE TRP THR ASP GLY SER VAL THR PRO LEU
SEQRES 17 A 315 GLU ALA LEU ASN GLN ALA VAL GLU ILE LEU ARG GLU HIS
SEQRES 18 A 315 LEU THR TYR PHE SER ASN PRO GLN ALA ALA ALA VAL ALA
SEQRES 19 A 315 ALA PRO GLU GLU ALA LYS GLU PRO GLU ALA PRO PRO GLU
SEQRES 20 A 315 GLN GLU GLU GLU LEU ASP LEU PRO LEU GLU GLU LEU GLY
SEQRES 21 A 315 LEU SER THR ARG VAL LEU HIS SER LEU LYS GLU GLU GLY
SEQRES 22 A 315 ILE GLU SER VAL ARG ALA LEU LEU ALA LEU ASN LEU LYS
SEQRES 23 A 315 ASP LEU LYS ASN ILE PRO GLY ILE GLY GLU ARG SER LEU
SEQRES 24 A 315 GLU GLU ILE LYS GLU ALA LEU GLU LYS LYS GLY PHE THR
SEQRES 25 A 315 LEU LYS GLU
SEQRES 1 B 315 MET LEU ASP SER LYS LEU LYS ALA PRO VAL PHE THR VAL
SEQRES 2 B 315 ARG THR GLN GLY ARG GLU TYR GLY GLU PHE VAL LEU GLU
SEQRES 3 B 315 PRO LEU GLU ARG GLY PHE GLY VAL THR LEU GLY ASN PRO
SEQRES 4 B 315 LEU ARG ARG ILE LEU LEU SER SER ILE PRO GLY THR ALA
SEQRES 5 B 315 VAL THR SER VAL TYR ILE GLU ASP VAL LEU HIS GLU PHE
SEQRES 6 B 315 SER THR ILE PRO GLY VAL LYS GLU ASP VAL VAL GLU ILE
SEQRES 7 B 315 ILE LEU ASN LEU LYS GLU LEU VAL VAL ARG PHE LEU ASN
SEQRES 8 B 315 PRO SER LEU GLN THR VAL THR LEU LEU LEU LYS ALA GLU
SEQRES 9 B 315 GLY PRO LYS GLU VAL LYS ALA ARG ASP PHE LEU PRO VAL
SEQRES 10 B 315 ALA ASP VAL GLU ILE MET ASN PRO ASP LEU HIS ILE ALA
SEQRES 11 B 315 THR LEU GLU GLU GLY GLY ARG LEU ASN MET GLU VAL ARG
SEQRES 12 B 315 VAL ASP ARG GLY VAL GLY TYR VAL PRO ALA GLU LYS HIS
SEQRES 13 B 315 GLY ILE LYS ASP ARG ILE ASN ALA ILE PRO VAL ASP ALA
SEQRES 14 B 315 VAL PHE SER PRO VAL ARG ARG VAL ALA PHE GLN VAL GLU
SEQRES 15 B 315 ASP THR ARG LEU GLY GLN ARG THR ASP LEU ASP LYS LEU
SEQRES 16 B 315 THR LEU ARG ILE TRP THR ASP GLY SER VAL THR PRO LEU
SEQRES 17 B 315 GLU ALA LEU ASN GLN ALA VAL GLU ILE LEU ARG GLU HIS
SEQRES 18 B 315 LEU THR TYR PHE SER ASN PRO GLN ALA ALA ALA VAL ALA
SEQRES 19 B 315 ALA PRO GLU GLU ALA LYS GLU PRO GLU ALA PRO PRO GLU
SEQRES 20 B 315 GLN GLU GLU GLU LEU ASP LEU PRO LEU GLU GLU LEU GLY
SEQRES 21 B 315 LEU SER THR ARG VAL LEU HIS SER LEU LYS GLU GLU GLY
SEQRES 22 B 315 ILE GLU SER VAL ARG ALA LEU LEU ALA LEU ASN LEU LYS
SEQRES 23 B 315 ASP LEU LYS ASN ILE PRO GLY ILE GLY GLU ARG SER LEU
SEQRES 24 B 315 GLU GLU ILE LYS GLU ALA LEU GLU LYS LYS GLY PHE THR
SEQRES 25 B 315 LEU LYS GLU
SEQRES 1 C 1119 MET GLU ILE LYS ARG PHE GLY ARG ILE ARG GLU VAL ILE
SEQRES 2 C 1119 PRO LEU PRO PRO LEU THR GLU ILE GLN VAL GLU SER TYR
SEQRES 3 C 1119 ARG ARG ALA LEU GLN ALA ASP VAL PRO PRO GLU LYS ARG
SEQRES 4 C 1119 GLU ASN VAL GLY ILE GLN ALA ALA PHE ARG GLU THR PHE
SEQRES 5 C 1119 PRO ILE GLU GLU GLU ASP LYS GLY LYS GLY GLY LEU VAL
SEQRES 6 C 1119 LEU ASP PHE LEU GLU TYR ARG LEU GLY GLU PRO PRO PHE
SEQRES 7 C 1119 PRO GLN ASP GLU CYS ARG GLU LYS ASP LEU THR TYR GLN
SEQRES 8 C 1119 ALA PRO LEU TYR ALA ARG LEU GLN LEU ILE HIS LYS ASP
SEQRES 9 C 1119 THR GLY LEU ILE LYS GLU ASP GLU VAL PHE LEU GLY HIS
SEQRES 10 C 1119 ILE PRO LEU MET THR GLU ASP GLY SER PHE ILE ILE ASN
SEQRES 11 C 1119 GLY ALA ASP ARG VAL ILE VAL SER GLN ILE HIS ARG SER
SEQRES 12 C 1119 PRO GLY VAL TYR PHE THR PRO ASP PRO ALA ARG PRO GLY
SEQRES 13 C 1119 ARG TYR ILE ALA SER ILE ILE PRO LEU PRO LYS ARG GLY
SEQRES 14 C 1119 PRO TRP ILE ASP LEU GLU VAL GLU PRO ASN GLY VAL VAL
SEQRES 15 C 1119 SER MET LYS VAL ASN LYS ARG LYS PHE PRO LEU VAL LEU
SEQRES 16 C 1119 LEU LEU ARG VAL LEU GLY TYR ASP GLN GLU THR LEU ALA
SEQRES 17 C 1119 ARG GLU LEU GLY ALA TYR GLY GLU LEU VAL GLN GLY LEU
SEQRES 18 C 1119 MET ASP GLU SER VAL PHE ALA MET ARG PRO GLU GLU ALA
SEQRES 19 C 1119 LEU ILE ARG LEU PHE THR LEU LEU ARG PRO GLY ASP PRO
SEQRES 20 C 1119 PRO LYS ARG ASP LYS ALA VAL ALA TYR VAL TYR GLY LEU
SEQRES 21 C 1119 ILE ALA ASP PRO ARG ARG TYR ASP LEU GLY GLU ALA GLY
SEQRES 22 C 1119 ARG TYR LYS ALA GLU GLU LYS LEU GLY ILE ARG LEU SER
SEQRES 23 C 1119 GLY ARG THR LEU ALA ARG PHE GLU ASP GLY GLU PHE LYS
SEQRES 24 C 1119 ASP GLU VAL PHE LEU PRO THR LEU ARG TYR LEU PHE ALA
SEQRES 25 C 1119 LEU THR ALA GLY VAL PRO GLY HIS GLU VAL ASP ASP ILE
SEQRES 26 C 1119 ASP HIS LEU GLY ASN ARG ARG ILE ARG THR VAL GLY GLU
SEQRES 27 C 1119 LEU MET THR ASP GLN PHE ARG VAL GLY LEU ALA ARG LEU
SEQRES 28 C 1119 ALA ARG GLY VAL ARG GLU ARG MET LEU MET GLY SER GLU
SEQRES 29 C 1119 ASP SER LEU THR PRO ALA LYS LEU VAL ASN SER ARG PRO
SEQRES 30 C 1119 LEU GLU ALA ALA ILE ARG GLU PHE PHE SER ARG SER GLN
SEQRES 31 C 1119 LEU SER GLN PHE LYS ASP GLU THR ASN PRO LEU SER SER
SEQRES 32 C 1119 LEU ARG HIS LYS ARG ARG ILE SER ALA LEU GLY PRO GLY
SEQRES 33 C 1119 GLY LEU THR ARG GLU ARG ALA GLY PHE ASP VAL ARG ASP
SEQRES 34 C 1119 VAL HIS ARG THR HIS TYR GLY ARG ILE CYS PRO VAL GLU
SEQRES 35 C 1119 THR PRO GLU GLY ALA ASN ILE GLY LEU ILE THR SER LEU
SEQRES 36 C 1119 ALA ALA TYR ALA ARG VAL ASP GLU LEU GLY PHE ILE ARG
SEQRES 37 C 1119 THR PRO TYR ARG ARG VAL VAL GLY GLY VAL VAL THR ASP
SEQRES 38 C 1119 GLU VAL VAL TYR MET THR ALA THR GLU GLU ASP ARG TYR
SEQRES 39 C 1119 THR ILE ALA GLN ALA ASN THR PRO LEU GLU GLY ASN ARG
SEQRES 40 C 1119 ILE ALA ALA GLU ARG VAL VAL ALA ARG ARG LYS GLY GLU
SEQRES 41 C 1119 PRO VAL ILE VAL SER PRO GLU GLU VAL GLU PHE MET ASP
SEQRES 42 C 1119 VAL SER PRO LYS GLN VAL PHE SER VAL ASN THR ASN LEU
SEQRES 43 C 1119 ILE PRO PHE LEU GLU HIS ASP ASP ALA ASN ARG ALA LEU
SEQRES 44 C 1119 MET GLY SER ASN MET GLN THR GLN ALA VAL PRO LEU ILE
SEQRES 45 C 1119 ARG ALA GLN ALA PRO VAL VAL MET THR GLY LEU GLU GLU
SEQRES 46 C 1119 ARG VAL VAL ARG ASP SER LEU ALA ALA LEU TYR ALA GLU
SEQRES 47 C 1119 GLU ASP GLY GLU VAL ALA LYS VAL ASP GLY ASN ARG ILE
SEQRES 48 C 1119 VAL VAL ARG TYR GLU ASP GLY ARG LEU VAL GLU TYR PRO
SEQRES 49 C 1119 LEU ARG ARG PHE TYR ARG SER ASN GLN GLY THR ALA LEU
SEQRES 50 C 1119 ASP GLN ARG PRO ARG VAL VAL VAL GLY GLN ARG VAL ARG
SEQRES 51 C 1119 LYS GLY ASP LEU LEU ALA ASP GLY PRO ALA SER GLU ASN
SEQRES 52 C 1119 GLY PHE LEU ALA LEU GLY GLN ASN VAL LEU VAL ALA ILE
SEQRES 53 C 1119 MET PRO PHE ASP GLY TYR ASN PHE GLU ASP ALA ILE VAL
SEQRES 54 C 1119 ILE SER GLU GLU LEU LEU LYS ARG ASP PHE TYR THR SER
SEQRES 55 C 1119 ILE HIS ILE GLU ARG TYR GLU ILE GLU ALA ARG ASP THR
SEQRES 56 C 1119 LYS LEU GLY PRO GLU ARG ILE THR ARG ASP ILE PRO HIS
SEQRES 57 C 1119 LEU SER GLU ALA ALA LEU ARG ASP LEU ASP GLU GLU GLY
SEQRES 58 C 1119 VAL VAL ARG ILE GLY ALA GLU VAL LYS PRO GLY ASP ILE
SEQRES 59 C 1119 LEU VAL GLY ARG THR SER PHE LYS GLY GLU SER GLU PRO
SEQRES 60 C 1119 THR PRO GLU GLU ARG LEU LEU ARG SER ILE PHE GLY GLU
SEQRES 61 C 1119 LYS ALA ARG ASP VAL LYS ASP THR SER LEU ARG VAL PRO
SEQRES 62 C 1119 PRO GLY GLU GLY GLY ILE VAL VAL ARG THR VAL ARG LEU
SEQRES 63 C 1119 ARG ARG GLY ASP PRO GLY VAL GLU LEU LYS PRO GLY VAL
SEQRES 64 C 1119 ARG GLU VAL VAL ARG VAL TYR VAL ALA GLN LYS ARG LYS
SEQRES 65 C 1119 LEU GLN VAL GLY ASP LYS LEU ALA ASN ARG HIS GLY ASN
SEQRES 66 C 1119 LYS GLY VAL VAL ALA LYS ILE LEU PRO VAL GLU ASP MET
SEQRES 67 C 1119 PRO HIS LEU PRO ASP GLY THR PRO VAL ASP VAL ILE LEU
SEQRES 68 C 1119 ASN PRO LEU GLY VAL PRO SER ARG MET ASN LEU GLY GLN
SEQRES 69 C 1119 ILE LEU GLU THR HIS LEU GLY LEU ALA GLY TYR PHE LEU
SEQRES 70 C 1119 GLY GLN ARG TYR ILE SER PRO ILE PHE ASP GLY ALA LYS
SEQRES 71 C 1119 GLU PRO GLU ILE LYS GLU LEU LEU ALA GLN ALA PHE GLU
SEQRES 72 C 1119 VAL TYR PHE GLY LYS ARG LYS GLY GLU GLY PHE GLY VAL
SEQRES 73 C 1119 ASP LYS ARG GLU VAL GLU VAL LEU ARG ARG ALA GLU LYS
SEQRES 74 C 1119 LEU GLY LEU VAL THR PRO GLY LYS THR PRO GLU GLU GLN
SEQRES 75 C 1119 LEU LYS GLU LEU PHE LEU GLN GLY LYS VAL VAL LEU TYR
SEQRES 76 C 1119 ASP GLY ARG THR GLY GLU PRO ILE GLU GLY PRO ILE VAL
SEQRES 77 C 1119 VAL GLY GLN MET PHE ILE MET LYS LEU TYR HIS MET VAL
SEQRES 78 C 1119 GLU ASP LYS MET HIS ALA ARG SER THR GLY PRO TYR SER
SEQRES 79 C 1119 LEU ILE THR GLN GLN PRO LEU GLY GLY LYS ALA GLN PHE
SEQRES 80 C 1119 GLY GLY GLN ARG PHE GLY GLU MET GLU VAL TRP ALA LEU
SEQRES 81 C 1119 GLU ALA TYR GLY ALA ALA HIS THR LEU GLN GLU MET LEU
SEQRES 82 C 1119 THR LEU LYS SER ASP ASP ILE GLU GLY ARG ASN ALA ALA
SEQRES 83 C 1119 TYR GLU ALA ILE ILE LYS GLY GLU ASP VAL PRO GLU PRO
SEQRES 84 C 1119 SER VAL PRO GLU SER PHE ARG VAL LEU VAL LYS GLU LEU
SEQRES 85 C 1119 GLN ALA LEU ALA LEU ASP VAL GLN THR LEU ASP GLU LYS
SEQRES 86 C 1119 ASP ASN PRO VAL ASP ILE PHE GLU GLY LEU ALA SER LYS
SEQRES 87 C 1119 ARG
SEQRES 1 D 1524 MET LYS LYS GLU VAL ARG LYS VAL ARG ILE ALA LEU ALA
SEQRES 2 D 1524 SER PRO GLU LYS ILE ARG SER TRP SER TYR GLY GLU VAL
SEQRES 3 D 1524 GLU LYS PRO GLU THR ILE ASN TYR ARG THR LEU LYS PRO
SEQRES 4 D 1524 GLU ARG ASP GLY LEU PHE ASP GLU ARG ILE PHE GLY PRO
SEQRES 5 D 1524 ILE LYS ASP TYR GLU CYS ALA CYS GLY LYS TYR LYS ARG
SEQRES 6 D 1524 GLN ARG PHE GLU GLY LYS VAL CYS GLU ARG CYS GLY VAL
SEQRES 7 D 1524 GLU VAL THR LYS SER ILE VAL ARG ARG TYR ARG MET GLY
SEQRES 8 D 1524 HIS ILE GLU LEU ALA THR PRO ALA ALA HIS ILE TRP PHE
SEQRES 9 D 1524 VAL LYS ASP VAL PRO SER LYS ILE GLY THR LEU LEU ASP
SEQRES 10 D 1524 LEU SER ALA THR GLU LEU GLU GLN VAL LEU TYR PHE SER
SEQRES 11 D 1524 LYS TYR ILE VAL LEU ASP PRO LYS GLY ALA ILE LEU ASN
SEQRES 12 D 1524 GLY VAL PRO VAL GLU LYS ARG GLN LEU LEU THR ASP GLU
SEQRES 13 D 1524 GLU TYR ARG GLU LEU ARG TYR GLY LYS GLN GLU THR TYR
SEQRES 14 D 1524 PRO LEU PRO PRO GLY VAL ASP ALA LEU VAL LYS ASP GLY
SEQRES 15 D 1524 GLU GLU VAL VAL LYS GLY GLN GLU LEU ALA PRO GLY VAL
SEQRES 16 D 1524 VAL SER ARG LEU ASP GLY VAL ALA LEU TYR ARG PHE PRO
SEQRES 17 D 1524 ARG ARG VAL ARG VAL GLU TYR VAL LYS LYS GLU ARG ALA
SEQRES 18 D 1524 GLY LEU ARG LEU PRO LEU ALA ALA TRP VAL GLU LYS GLU
SEQRES 19 D 1524 ALA TYR LYS PRO GLY GLU ILE LEU ALA GLU LEU PRO GLU
SEQRES 20 D 1524 PRO TYR LEU PHE ARG ALA GLU GLU GLU GLY VAL VAL GLU
SEQRES 21 D 1524 LEU LYS GLU LEU GLU GLU GLY ALA PHE LEU VAL LEU ARG
SEQRES 22 D 1524 ARG GLU ASP GLU PRO VAL ALA THR TYR PHE LEU PRO VAL
SEQRES 23 D 1524 GLY MET THR PRO LEU VAL VAL HIS GLY GLU ILE VAL GLU
SEQRES 24 D 1524 LYS GLY GLN PRO LEU ALA GLU ALA LYS GLY LEU LEU ARG
SEQRES 25 D 1524 MET PRO ARG GLN VAL ARG ALA ALA GLN VAL GLU ALA GLU
SEQRES 26 D 1524 GLU GLU GLY GLU THR VAL TYR LEU THR LEU PHE LEU GLU
SEQRES 27 D 1524 TRP THR GLU PRO LYS ASP TYR ARG VAL GLN PRO HIS MET
SEQRES 28 D 1524 ASN VAL VAL VAL PRO GLU GLY ALA ARG VAL GLU ALA GLY
SEQRES 29 D 1524 ASP LYS ILE VAL ALA ALA ILE ASP PRO GLU GLU GLU VAL
SEQRES 30 D 1524 ILE ALA GLU ALA GLU GLY VAL VAL HIS LEU HIS GLU PRO
SEQRES 31 D 1524 ALA SER ILE LEU VAL VAL LYS ALA ARG VAL TYR PRO PHE
SEQRES 32 D 1524 GLU ASP ASP VAL GLU VAL SER THR GLY ASP ARG VAL ALA
SEQRES 33 D 1524 PRO GLY ASP VAL LEU ALA ASP GLY GLY LYS VAL LYS SER
SEQRES 34 D 1524 ASP VAL TYR GLY ARG VAL GLU VAL ASP LEU VAL ARG ASN
SEQRES 35 D 1524 VAL VAL ARG VAL VAL GLU SER TYR ASP ILE ASP ALA ARG
SEQRES 36 D 1524 MET GLY ALA GLU ALA ILE GLN GLN LEU LEU LYS GLU LEU
SEQRES 37 D 1524 ASP LEU GLU ALA LEU GLU LYS GLU LEU LEU GLU GLU MET
SEQRES 38 D 1524 LYS HIS PRO SER ARG ALA ARG ARG ALA LYS ALA ARG LYS
SEQRES 39 D 1524 ARG LEU GLU VAL VAL ARG ALA PHE LEU ASP SER GLY ASN
SEQRES 40 D 1524 ARG PRO GLU TRP MET ILE LEU GLU ALA VAL PRO VAL LEU
SEQRES 41 D 1524 PRO PRO ASP LEU ARG PRO MET VAL GLN VAL ASP GLY GLY
SEQRES 42 D 1524 ARG PHE ALA THR SER ASP LEU ASN ASP LEU TYR ARG ARG
SEQRES 43 D 1524 LEU ILE ASN ARG ASN ASN ARG LEU LYS LYS LEU LEU ALA
SEQRES 44 D 1524 GLN GLY ALA PRO GLU ILE ILE ILE ARG ASN GLU LYS ARG
SEQRES 45 D 1524 MET LEU GLN GLU ALA VAL ASP ALA LEU LEU ASP ASN GLY
SEQRES 46 D 1524 ARG ARG GLY ALA PRO VAL THR ASN PRO GLY SER ASP ARG
SEQRES 47 D 1524 PRO LEU ARG SER LEU THR ASP ILE LEU SER GLY LYS GLN
SEQRES 48 D 1524 GLY ARG PHE ARG GLN ASN LEU LEU GLY LYS ARG VAL ASP
SEQRES 49 D 1524 TYR SER GLY ARG SER VAL ILE VAL VAL GLY PRO GLN LEU
SEQRES 50 D 1524 LYS LEU HIS GLN CYS GLY LEU PRO LYS ARG MET ALA LEU
SEQRES 51 D 1524 GLU LEU PHE LYS PRO PHE LEU LEU LYS LYS MET GLU GLU
SEQRES 52 D 1524 LYS GLY ILE ALA PRO ASN VAL LYS ALA ALA ARG ARG MET
SEQRES 53 D 1524 LEU GLU ARG GLN ARG ASP ILE LYS ASP GLU VAL TRP ASP
SEQRES 54 D 1524 ALA LEU GLU GLU VAL ILE HIS GLY LYS VAL VAL LEU LEU
SEQRES 55 D 1524 ASN ARG ALA PRO THR LEU HIS ARG LEU GLY ILE GLN ALA
SEQRES 56 D 1524 PHE GLN PRO VAL LEU VAL GLU GLY GLN SER ILE GLN LEU
SEQRES 57 D 1524 HIS PRO LEU VAL CYS GLU ALA PHE ASN ALA ASP PHE ASP
SEQRES 58 D 1524 GLY ASP GLN MET ALA VAL HIS VAL PRO LEU SER SER PHE
SEQRES 59 D 1524 ALA GLN ALA GLU ALA ARG ILE GLN MET LEU SER ALA HIS
SEQRES 60 D 1524 ASN LEU LEU SER PRO ALA SER GLY GLU PRO LEU ALA LYS
SEQRES 61 D 1524 PRO SER ARG ASP ILE ILE LEU GLY LEU TYR TYR ILE THR
SEQRES 62 D 1524 GLN VAL ARG LYS GLU LYS LYS GLY ALA GLY LEU GLU PHE
SEQRES 63 D 1524 ALA THR PRO GLU GLU ALA LEU ALA ALA HIS GLU ARG GLY
SEQRES 64 D 1524 GLU VAL ALA LEU ASN ALA PRO ILE LYS VAL ALA GLY ARG
SEQRES 65 D 1524 GLU THR SER VAL GLY ARG LEU LYS TYR VAL PHE ALA ASN
SEQRES 66 D 1524 PRO ASP GLU ALA LEU LEU ALA VAL ALA HIS GLY ILE VAL
SEQRES 67 D 1524 ASP LEU GLN ASP VAL VAL THR VAL ARG TYR MET GLY LYS
SEQRES 68 D 1524 ARG LEU GLU THR SER PRO GLY ARG ILE LEU PHE ALA ARG
SEQRES 69 D 1524 ILE VAL ALA GLU ALA VAL GLU ASP GLU LYS VAL ALA TRP
SEQRES 70 D 1524 GLU LEU ILE GLN LEU ASP VAL PRO GLN GLU LYS ASN SER
SEQRES 71 D 1524 LEU LYS ASP LEU VAL TYR GLN ALA PHE LEU ARG LEU GLY
SEQRES 72 D 1524 MET GLU LYS THR ALA ARG LEU LEU ASP ALA LEU LYS TYR
SEQRES 73 D 1524 TYR GLY PHE THR PHE SER THR THR SER GLY ILE THR ILE
SEQRES 74 D 1524 GLY ILE ASP ASP ALA VAL ILE PRO GLU GLU LYS LYS GLN
SEQRES 75 D 1524 TYR LEU GLU GLU ALA ASP ARG LYS LEU LEU GLN ILE GLU
SEQRES 76 D 1524 GLN ALA TYR GLU MET GLY PHE LEU THR ASP ARG GLU ARG
SEQRES 77 D 1524 TYR ASP GLN ILE LEU GLN LEU TRP THR GLU THR THR GLU
SEQRES 78 D 1524 LYS VAL THR GLN ALA VAL PHE LYS ASN PHE GLU GLU ASN
SEQRES 79 D 1524 TYR PRO PHE ASN PRO LEU TYR VAL MET ALA GLN SER GLY
SEQRES 80 D 1524 ALA ARG GLY ASN PRO GLN GLN ILE ARG GLN LEU CYS GLY
SEQRES 81 D 1524 LEU ARG GLY LEU MET GLN LYS PRO SER GLY GLU THR PHE
SEQRES 82 D 1524 GLU VAL PRO VAL ARG SER SER PHE ARG GLU GLY LEU THR
SEQRES 83 D 1524 VAL LEU GLU TYR PHE ILE SER SER HIS GLY ALA ARG LYS
SEQRES 84 D 1524 GLY GLY ALA ASP THR ALA LEU ARG THR ALA ASP SER GLY
SEQRES 85 D 1524 TYR LEU THR ARG LYS LEU VAL ASP VAL THR HIS GLU ILE
SEQRES 86 D 1524 VAL VAL ARG GLU ALA ASP CYS GLY THR THR ASN TYR ILE
SEQRES 87 D 1524 SER VAL PRO LEU PHE GLN PRO ASP GLU VAL THR ARG SER
SEQRES 88 D 1524 LEU ARG LEU ARG LYS ARG ALA ASP ILE GLU ALA GLY LEU
SEQRES 89 D 1524 TYR GLY ARG VAL LEU ALA ARG GLU VAL GLU VAL LEU GLY
SEQRES 90 D 1524 VAL ARG LEU GLU GLU GLY ARG TYR LEU SER MET ASP ASP
SEQRES 91 D 1524 VAL HIS LEU LEU ILE LYS ALA ALA GLU ALA GLY GLU ILE
SEQRES 92 D 1524 GLN GLU VAL PRO VAL ARG SER PRO LEU THR CYS GLN THR
SEQRES 93 D 1524 ARG TYR GLY VAL CYS GLN LYS CYS TYR GLY TYR ASP LEU
SEQRES 94 D 1524 SER MET ALA ARG PRO VAL SER ILE GLY GLU ALA VAL GLY
SEQRES 95 D 1524 ILE VAL ALA ALA GLN SER ILE GLY GLU PRO GLY THR GLN
SEQRES 96 D 1524 LEU THR MET ARG THR PHE HIS THR GLY GLY VAL ALA GLY
SEQRES 97 D 1524 ALA ALA ASP ILE THR GLN GLY LEU PRO ARG VAL ILE GLU
SEQRES 98 D 1524 LEU PHE GLU ALA ARG ARG PRO LYS ALA LYS ALA VAL ILE
SEQRES 99 D 1524 SER GLU ILE ASP GLY VAL VAL ARG ILE GLU GLU THR GLU
SEQRES 100 D 1524 GLU LYS LEU SER VAL PHE VAL GLU SER GLU GLY PHE SER
SEQRES 101 D 1524 LYS GLU TYR LYS LEU PRO LYS GLU ALA ARG LEU LEU VAL
SEQRES 102 D 1524 LYS ASP GLY ASP TYR VAL GLU ALA GLY GLN PRO LEU THR
SEQRES 103 D 1524 ARG GLY ALA ILE ASP PRO HIS GLN LEU LEU GLU ALA LYS
SEQRES 104 D 1524 GLY PRO GLU ALA VAL GLU ARG TYR LEU VAL GLU GLU ILE
SEQRES 105 D 1524 GLN LYS VAL TYR ARG ALA GLN GLY VAL LYS LEU HIS ASP
SEQRES 106 D 1524 LYS HIS ILE GLU ILE VAL VAL ARG GLN MET MET LYS TYR
SEQRES 107 D 1524 VAL GLU VAL THR ASP PRO GLY ASP SER ARG LEU LEU GLU
SEQRES 108 D 1524 GLY GLN VAL LEU GLU LYS TRP ASP VAL GLU ALA LEU ASN
SEQRES 109 D 1524 GLU ARG LEU ILE ALA GLU GLY LYS THR PRO VAL ALA TRP
SEQRES 110 D 1524 LYS PRO LEU LEU MET GLY VAL THR LYS SER ALA LEU SER
SEQRES 111 D 1524 THR LYS SER TRP LEU SER ALA ALA SER PHE GLN ASN THR
SEQRES 112 D 1524 THR HIS VAL LEU THR GLU ALA ALA ILE ALA GLY LYS LYS
SEQRES 113 D 1524 ASP GLU LEU ILE GLY LEU LYS GLU ASN VAL ILE LEU GLY
SEQRES 114 D 1524 ARG LEU ILE PRO ALA GLY THR GLY SER ASP PHE VAL ARG
SEQRES 115 D 1524 PHE THR GLN VAL VAL ASP GLN LYS THR LEU LYS ALA ILE
SEQRES 116 D 1524 GLU GLU ALA ARG LYS GLU ALA VAL GLU ALA LYS GLU ARG
SEQRES 117 D 1524 PRO ALA ALA ARG ARG GLY VAL LYS ARG GLU GLN PRO GLY
SEQRES 118 D 1524 LYS GLN ALA
SEQRES 1 E 99 MET ALA GLU PRO GLY ILE ASP LYS LEU PHE GLY MET VAL
SEQRES 2 E 99 ASP SER LYS TYR ARG LEU THR VAL VAL VAL ALA LYS ARG
SEQRES 3 E 99 ALA GLN GLN LEU LEU ARG HIS GLY PHE LYS ASN THR VAL
SEQRES 4 E 99 LEU GLU PRO GLU GLU ARG PRO LYS MET GLN THR LEU GLU
SEQRES 5 E 99 GLY LEU PHE ASP ASP PRO ASN ALA VAL THR TRP ALA MET
SEQRES 6 E 99 LYS GLU LEU LEU THR GLY ARG LEU VAL PHE GLY GLU ASN
SEQRES 7 E 99 LEU VAL PRO GLU ASP ARG LEU GLN LYS GLU MET GLU ARG
SEQRES 8 E 99 LEU TYR PRO VAL GLU ARG GLU GLU
SEQRES 1 F 423 MET LYS LYS SER LYS ARG LYS ASN ALA GLN ALA GLN GLU
SEQRES 2 F 423 ALA GLN GLU THR GLU VAL LEU VAL GLN GLU GLU ALA GLU
SEQRES 3 F 423 GLU LEU PRO GLU PHE PRO GLU GLY GLU PRO ASP PRO ASP
SEQRES 4 F 423 LEU GLU ASP PRO ASP LEU ALA LEU GLU ASP ASP LEU LEU
SEQRES 5 F 423 ASP LEU PRO GLU GLU GLY GLU GLY LEU ASP LEU GLU GLU
SEQRES 6 F 423 GLU GLU GLU ASP LEU PRO ILE PRO LYS ILE SER THR SER
SEQRES 7 F 423 ASP PRO VAL ARG GLN TYR LEU HIS GLU ILE GLY GLN VAL
SEQRES 8 F 423 PRO LEU LEU THR LEU GLU GLU GLU VAL GLU LEU ALA ARG
SEQRES 9 F 423 LYS VAL GLU GLU GLY MET GLU ALA ILE LYS LYS LEU SER
SEQRES 10 F 423 GLU ILE THR GLY LEU ASP PRO ASP LEU ILE ARG GLU VAL
SEQRES 11 F 423 VAL ARG ALA LYS ILE LEU GLY SER ALA ARG VAL ARG HIS
SEQRES 12 F 423 ILE PRO GLY LEU LYS GLU THR LEU ASP PRO LYS THR VAL
SEQRES 13 F 423 GLU GLU ILE ASP GLN LYS LEU LYS SER LEU PRO LYS GLU
SEQRES 14 F 423 HIS LYS ARG TYR LEU HIS ILE ALA ARG GLU GLY GLU ALA
SEQRES 15 F 423 ALA ARG GLN HIS LEU ILE GLU ALA ASN LEU ARG LEU VAL
SEQRES 16 F 423 VAL SER ILE ALA LYS LYS TYR THR GLY ARG GLY LEU SER
SEQRES 17 F 423 PHE LEU ASP LEU ILE GLN GLU GLY ASN GLN GLY LEU ILE
SEQRES 18 F 423 ARG ALA VAL GLU LYS PHE GLU TYR LYS ARG ARG PHE LYS
SEQRES 19 F 423 PHE SER THR TYR ALA THR TRP TRP ILE ARG GLN ALA ILE
SEQRES 20 F 423 ASN ARG ALA ILE ALA ASP GLN ALA ARG THR ILE ARG ILE
SEQRES 21 F 423 PRO VAL HIS MET VAL GLU THR ILE ASN LYS LEU SER ARG
SEQRES 22 F 423 THR ALA ARG GLN LEU GLN GLN GLU LEU GLY ARG GLU PRO
SEQRES 23 F 423 THR TYR GLU GLU ILE ALA GLU ALA MET GLY PRO GLY TRP
SEQRES 24 F 423 ASP ALA LYS ARG VAL GLU GLU THR LEU LYS ILE ALA GLN
SEQRES 25 F 423 GLU PRO VAL SER LEU GLU THR PRO ILE GLY ASP GLU LYS
SEQRES 26 F 423 ASP SER PHE TYR GLY ASP PHE ILE PRO ASP GLU HIS LEU
SEQRES 27 F 423 PRO SER PRO VAL ASP ALA ALA THR GLN SER LEU LEU SER
SEQRES 28 F 423 GLU GLU LEU GLU LYS ALA LEU SER LYS LEU SER GLU ARG
SEQRES 29 F 423 GLU ALA MET VAL LEU LYS LEU ARG LYS GLY LEU ILE ASP
SEQRES 30 F 423 GLY ARG GLU HIS THR LEU GLU GLU VAL GLY ALA PHE PHE
SEQRES 31 F 423 GLY VAL THR ARG GLU ARG ILE ARG GLN ILE GLU ASN LYS
SEQRES 32 F 423 ALA LEU ARG LYS LEU LYS TYR HIS GLU SER ARG THR ARG
SEQRES 33 F 423 LYS LEU ARG ASP PHE LEU ASP
SEQRES 1 K 315 MET LEU ASP SER LYS LEU LYS ALA PRO VAL PHE THR VAL
SEQRES 2 K 315 ARG THR GLN GLY ARG GLU TYR GLY GLU PHE VAL LEU GLU
SEQRES 3 K 315 PRO LEU GLU ARG GLY PHE GLY VAL THR LEU GLY ASN PRO
SEQRES 4 K 315 LEU ARG ARG ILE LEU LEU SER SER ILE PRO GLY THR ALA
SEQRES 5 K 315 VAL THR SER VAL TYR ILE GLU ASP VAL LEU HIS GLU PHE
SEQRES 6 K 315 SER THR ILE PRO GLY VAL LYS GLU ASP VAL VAL GLU ILE
SEQRES 7 K 315 ILE LEU ASN LEU LYS GLU LEU VAL VAL ARG PHE LEU ASN
SEQRES 8 K 315 PRO SER LEU GLN THR VAL THR LEU LEU LEU LYS ALA GLU
SEQRES 9 K 315 GLY PRO LYS GLU VAL LYS ALA ARG ASP PHE LEU PRO VAL
SEQRES 10 K 315 ALA ASP VAL GLU ILE MET ASN PRO ASP LEU HIS ILE ALA
SEQRES 11 K 315 THR LEU GLU GLU GLY GLY ARG LEU ASN MET GLU VAL ARG
SEQRES 12 K 315 VAL ASP ARG GLY VAL GLY TYR VAL PRO ALA GLU LYS HIS
SEQRES 13 K 315 GLY ILE LYS ASP ARG ILE ASN ALA ILE PRO VAL ASP ALA
SEQRES 14 K 315 VAL PHE SER PRO VAL ARG ARG VAL ALA PHE GLN VAL GLU
SEQRES 15 K 315 ASP THR ARG LEU GLY GLN ARG THR ASP LEU ASP LYS LEU
SEQRES 16 K 315 THR LEU ARG ILE TRP THR ASP GLY SER VAL THR PRO LEU
SEQRES 17 K 315 GLU ALA LEU ASN GLN ALA VAL GLU ILE LEU ARG GLU HIS
SEQRES 18 K 315 LEU THR TYR PHE SER ASN PRO GLN ALA ALA ALA VAL ALA
SEQRES 19 K 315 ALA PRO GLU GLU ALA LYS GLU PRO GLU ALA PRO PRO GLU
SEQRES 20 K 315 GLN GLU GLU GLU LEU ASP LEU PRO LEU GLU GLU LEU GLY
SEQRES 21 K 315 LEU SER THR ARG VAL LEU HIS SER LEU LYS GLU GLU GLY
SEQRES 22 K 315 ILE GLU SER VAL ARG ALA LEU LEU ALA LEU ASN LEU LYS
SEQRES 23 K 315 ASP LEU LYS ASN ILE PRO GLY ILE GLY GLU ARG SER LEU
SEQRES 24 K 315 GLU GLU ILE LYS GLU ALA LEU GLU LYS LYS GLY PHE THR
SEQRES 25 K 315 LEU LYS GLU
SEQRES 1 L 315 MET LEU ASP SER LYS LEU LYS ALA PRO VAL PHE THR VAL
SEQRES 2 L 315 ARG THR GLN GLY ARG GLU TYR GLY GLU PHE VAL LEU GLU
SEQRES 3 L 315 PRO LEU GLU ARG GLY PHE GLY VAL THR LEU GLY ASN PRO
SEQRES 4 L 315 LEU ARG ARG ILE LEU LEU SER SER ILE PRO GLY THR ALA
SEQRES 5 L 315 VAL THR SER VAL TYR ILE GLU ASP VAL LEU HIS GLU PHE
SEQRES 6 L 315 SER THR ILE PRO GLY VAL LYS GLU ASP VAL VAL GLU ILE
SEQRES 7 L 315 ILE LEU ASN LEU LYS GLU LEU VAL VAL ARG PHE LEU ASN
SEQRES 8 L 315 PRO SER LEU GLN THR VAL THR LEU LEU LEU LYS ALA GLU
SEQRES 9 L 315 GLY PRO LYS GLU VAL LYS ALA ARG ASP PHE LEU PRO VAL
SEQRES 10 L 315 ALA ASP VAL GLU ILE MET ASN PRO ASP LEU HIS ILE ALA
SEQRES 11 L 315 THR LEU GLU GLU GLY GLY ARG LEU ASN MET GLU VAL ARG
SEQRES 12 L 315 VAL ASP ARG GLY VAL GLY TYR VAL PRO ALA GLU LYS HIS
SEQRES 13 L 315 GLY ILE LYS ASP ARG ILE ASN ALA ILE PRO VAL ASP ALA
SEQRES 14 L 315 VAL PHE SER PRO VAL ARG ARG VAL ALA PHE GLN VAL GLU
SEQRES 15 L 315 ASP THR ARG LEU GLY GLN ARG THR ASP LEU ASP LYS LEU
SEQRES 16 L 315 THR LEU ARG ILE TRP THR ASP GLY SER VAL THR PRO LEU
SEQRES 17 L 315 GLU ALA LEU ASN GLN ALA VAL GLU ILE LEU ARG GLU HIS
SEQRES 18 L 315 LEU THR TYR PHE SER ASN PRO GLN ALA ALA ALA VAL ALA
SEQRES 19 L 315 ALA PRO GLU GLU ALA LYS GLU PRO GLU ALA PRO PRO GLU
SEQRES 20 L 315 GLN GLU GLU GLU LEU ASP LEU PRO LEU GLU GLU LEU GLY
SEQRES 21 L 315 LEU SER THR ARG VAL LEU HIS SER LEU LYS GLU GLU GLY
SEQRES 22 L 315 ILE GLU SER VAL ARG ALA LEU LEU ALA LEU ASN LEU LYS
SEQRES 23 L 315 ASP LEU LYS ASN ILE PRO GLY ILE GLY GLU ARG SER LEU
SEQRES 24 L 315 GLU GLU ILE LYS GLU ALA LEU GLU LYS LYS GLY PHE THR
SEQRES 25 L 315 LEU LYS GLU
SEQRES 1 M 1119 MET GLU ILE LYS ARG PHE GLY ARG ILE ARG GLU VAL ILE
SEQRES 2 M 1119 PRO LEU PRO PRO LEU THR GLU ILE GLN VAL GLU SER TYR
SEQRES 3 M 1119 ARG ARG ALA LEU GLN ALA ASP VAL PRO PRO GLU LYS ARG
SEQRES 4 M 1119 GLU ASN VAL GLY ILE GLN ALA ALA PHE ARG GLU THR PHE
SEQRES 5 M 1119 PRO ILE GLU GLU GLU ASP LYS GLY LYS GLY GLY LEU VAL
SEQRES 6 M 1119 LEU ASP PHE LEU GLU TYR ARG LEU GLY GLU PRO PRO PHE
SEQRES 7 M 1119 PRO GLN ASP GLU CYS ARG GLU LYS ASP LEU THR TYR GLN
SEQRES 8 M 1119 ALA PRO LEU TYR ALA ARG LEU GLN LEU ILE HIS LYS ASP
SEQRES 9 M 1119 THR GLY LEU ILE LYS GLU ASP GLU VAL PHE LEU GLY HIS
SEQRES 10 M 1119 ILE PRO LEU MET THR GLU ASP GLY SER PHE ILE ILE ASN
SEQRES 11 M 1119 GLY ALA ASP ARG VAL ILE VAL SER GLN ILE HIS ARG SER
SEQRES 12 M 1119 PRO GLY VAL TYR PHE THR PRO ASP PRO ALA ARG PRO GLY
SEQRES 13 M 1119 ARG TYR ILE ALA SER ILE ILE PRO LEU PRO LYS ARG GLY
SEQRES 14 M 1119 PRO TRP ILE ASP LEU GLU VAL GLU PRO ASN GLY VAL VAL
SEQRES 15 M 1119 SER MET LYS VAL ASN LYS ARG LYS PHE PRO LEU VAL LEU
SEQRES 16 M 1119 LEU LEU ARG VAL LEU GLY TYR ASP GLN GLU THR LEU ALA
SEQRES 17 M 1119 ARG GLU LEU GLY ALA TYR GLY GLU LEU VAL GLN GLY LEU
SEQRES 18 M 1119 MET ASP GLU SER VAL PHE ALA MET ARG PRO GLU GLU ALA
SEQRES 19 M 1119 LEU ILE ARG LEU PHE THR LEU LEU ARG PRO GLY ASP PRO
SEQRES 20 M 1119 PRO LYS ARG ASP LYS ALA VAL ALA TYR VAL TYR GLY LEU
SEQRES 21 M 1119 ILE ALA ASP PRO ARG ARG TYR ASP LEU GLY GLU ALA GLY
SEQRES 22 M 1119 ARG TYR LYS ALA GLU GLU LYS LEU GLY ILE ARG LEU SER
SEQRES 23 M 1119 GLY ARG THR LEU ALA ARG PHE GLU ASP GLY GLU PHE LYS
SEQRES 24 M 1119 ASP GLU VAL PHE LEU PRO THR LEU ARG TYR LEU PHE ALA
SEQRES 25 M 1119 LEU THR ALA GLY VAL PRO GLY HIS GLU VAL ASP ASP ILE
SEQRES 26 M 1119 ASP HIS LEU GLY ASN ARG ARG ILE ARG THR VAL GLY GLU
SEQRES 27 M 1119 LEU MET THR ASP GLN PHE ARG VAL GLY LEU ALA ARG LEU
SEQRES 28 M 1119 ALA ARG GLY VAL ARG GLU ARG MET LEU MET GLY SER GLU
SEQRES 29 M 1119 ASP SER LEU THR PRO ALA LYS LEU VAL ASN SER ARG PRO
SEQRES 30 M 1119 LEU GLU ALA ALA ILE ARG GLU PHE PHE SER ARG SER GLN
SEQRES 31 M 1119 LEU SER GLN PHE LYS ASP GLU THR ASN PRO LEU SER SER
SEQRES 32 M 1119 LEU ARG HIS LYS ARG ARG ILE SER ALA LEU GLY PRO GLY
SEQRES 33 M 1119 GLY LEU THR ARG GLU ARG ALA GLY PHE ASP VAL ARG ASP
SEQRES 34 M 1119 VAL HIS ARG THR HIS TYR GLY ARG ILE CYS PRO VAL GLU
SEQRES 35 M 1119 THR PRO GLU GLY ALA ASN ILE GLY LEU ILE THR SER LEU
SEQRES 36 M 1119 ALA ALA TYR ALA ARG VAL ASP GLU LEU GLY PHE ILE ARG
SEQRES 37 M 1119 THR PRO TYR ARG ARG VAL VAL GLY GLY VAL VAL THR ASP
SEQRES 38 M 1119 GLU VAL VAL TYR MET THR ALA THR GLU GLU ASP ARG TYR
SEQRES 39 M 1119 THR ILE ALA GLN ALA ASN THR PRO LEU GLU GLY ASN ARG
SEQRES 40 M 1119 ILE ALA ALA GLU ARG VAL VAL ALA ARG ARG LYS GLY GLU
SEQRES 41 M 1119 PRO VAL ILE VAL SER PRO GLU GLU VAL GLU PHE MET ASP
SEQRES 42 M 1119 VAL SER PRO LYS GLN VAL PHE SER VAL ASN THR ASN LEU
SEQRES 43 M 1119 ILE PRO PHE LEU GLU HIS ASP ASP ALA ASN ARG ALA LEU
SEQRES 44 M 1119 MET GLY SER ASN MET GLN THR GLN ALA VAL PRO LEU ILE
SEQRES 45 M 1119 ARG ALA GLN ALA PRO VAL VAL MET THR GLY LEU GLU GLU
SEQRES 46 M 1119 ARG VAL VAL ARG ASP SER LEU ALA ALA LEU TYR ALA GLU
SEQRES 47 M 1119 GLU ASP GLY GLU VAL ALA LYS VAL ASP GLY ASN ARG ILE
SEQRES 48 M 1119 VAL VAL ARG TYR GLU ASP GLY ARG LEU VAL GLU TYR PRO
SEQRES 49 M 1119 LEU ARG ARG PHE TYR ARG SER ASN GLN GLY THR ALA LEU
SEQRES 50 M 1119 ASP GLN ARG PRO ARG VAL VAL VAL GLY GLN ARG VAL ARG
SEQRES 51 M 1119 LYS GLY ASP LEU LEU ALA ASP GLY PRO ALA SER GLU ASN
SEQRES 52 M 1119 GLY PHE LEU ALA LEU GLY GLN ASN VAL LEU VAL ALA ILE
SEQRES 53 M 1119 MET PRO PHE ASP GLY TYR ASN PHE GLU ASP ALA ILE VAL
SEQRES 54 M 1119 ILE SER GLU GLU LEU LEU LYS ARG ASP PHE TYR THR SER
SEQRES 55 M 1119 ILE HIS ILE GLU ARG TYR GLU ILE GLU ALA ARG ASP THR
SEQRES 56 M 1119 LYS LEU GLY PRO GLU ARG ILE THR ARG ASP ILE PRO HIS
SEQRES 57 M 1119 LEU SER GLU ALA ALA LEU ARG ASP LEU ASP GLU GLU GLY
SEQRES 58 M 1119 VAL VAL ARG ILE GLY ALA GLU VAL LYS PRO GLY ASP ILE
SEQRES 59 M 1119 LEU VAL GLY ARG THR SER PHE LYS GLY GLU SER GLU PRO
SEQRES 60 M 1119 THR PRO GLU GLU ARG LEU LEU ARG SER ILE PHE GLY GLU
SEQRES 61 M 1119 LYS ALA ARG ASP VAL LYS ASP THR SER LEU ARG VAL PRO
SEQRES 62 M 1119 PRO GLY GLU GLY GLY ILE VAL VAL ARG THR VAL ARG LEU
SEQRES 63 M 1119 ARG ARG GLY ASP PRO GLY VAL GLU LEU LYS PRO GLY VAL
SEQRES 64 M 1119 ARG GLU VAL VAL ARG VAL TYR VAL ALA GLN LYS ARG LYS
SEQRES 65 M 1119 LEU GLN VAL GLY ASP LYS LEU ALA ASN ARG HIS GLY ASN
SEQRES 66 M 1119 LYS GLY VAL VAL ALA LYS ILE LEU PRO VAL GLU ASP MET
SEQRES 67 M 1119 PRO HIS LEU PRO ASP GLY THR PRO VAL ASP VAL ILE LEU
SEQRES 68 M 1119 ASN PRO LEU GLY VAL PRO SER ARG MET ASN LEU GLY GLN
SEQRES 69 M 1119 ILE LEU GLU THR HIS LEU GLY LEU ALA GLY TYR PHE LEU
SEQRES 70 M 1119 GLY GLN ARG TYR ILE SER PRO ILE PHE ASP GLY ALA LYS
SEQRES 71 M 1119 GLU PRO GLU ILE LYS GLU LEU LEU ALA GLN ALA PHE GLU
SEQRES 72 M 1119 VAL TYR PHE GLY LYS ARG LYS GLY GLU GLY PHE GLY VAL
SEQRES 73 M 1119 ASP LYS ARG GLU VAL GLU VAL LEU ARG ARG ALA GLU LYS
SEQRES 74 M 1119 LEU GLY LEU VAL THR PRO GLY LYS THR PRO GLU GLU GLN
SEQRES 75 M 1119 LEU LYS GLU LEU PHE LEU GLN GLY LYS VAL VAL LEU TYR
SEQRES 76 M 1119 ASP GLY ARG THR GLY GLU PRO ILE GLU GLY PRO ILE VAL
SEQRES 77 M 1119 VAL GLY GLN MET PHE ILE MET LYS LEU TYR HIS MET VAL
SEQRES 78 M 1119 GLU ASP LYS MET HIS ALA ARG SER THR GLY PRO TYR SER
SEQRES 79 M 1119 LEU ILE THR GLN GLN PRO LEU GLY GLY LYS ALA GLN PHE
SEQRES 80 M 1119 GLY GLY GLN ARG PHE GLY GLU MET GLU VAL TRP ALA LEU
SEQRES 81 M 1119 GLU ALA TYR GLY ALA ALA HIS THR LEU GLN GLU MET LEU
SEQRES 82 M 1119 THR LEU LYS SER ASP ASP ILE GLU GLY ARG ASN ALA ALA
SEQRES 83 M 1119 TYR GLU ALA ILE ILE LYS GLY GLU ASP VAL PRO GLU PRO
SEQRES 84 M 1119 SER VAL PRO GLU SER PHE ARG VAL LEU VAL LYS GLU LEU
SEQRES 85 M 1119 GLN ALA LEU ALA LEU ASP VAL GLN THR LEU ASP GLU LYS
SEQRES 86 M 1119 ASP ASN PRO VAL ASP ILE PHE GLU GLY LEU ALA SER LYS
SEQRES 87 M 1119 ARG
SEQRES 1 N 1524 MET LYS LYS GLU VAL ARG LYS VAL ARG ILE ALA LEU ALA
SEQRES 2 N 1524 SER PRO GLU LYS ILE ARG SER TRP SER TYR GLY GLU VAL
SEQRES 3 N 1524 GLU LYS PRO GLU THR ILE ASN TYR ARG THR LEU LYS PRO
SEQRES 4 N 1524 GLU ARG ASP GLY LEU PHE ASP GLU ARG ILE PHE GLY PRO
SEQRES 5 N 1524 ILE LYS ASP TYR GLU CYS ALA CYS GLY LYS TYR LYS ARG
SEQRES 6 N 1524 GLN ARG PHE GLU GLY LYS VAL CYS GLU ARG CYS GLY VAL
SEQRES 7 N 1524 GLU VAL THR LYS SER ILE VAL ARG ARG TYR ARG MET GLY
SEQRES 8 N 1524 HIS ILE GLU LEU ALA THR PRO ALA ALA HIS ILE TRP PHE
SEQRES 9 N 1524 VAL LYS ASP VAL PRO SER LYS ILE GLY THR LEU LEU ASP
SEQRES 10 N 1524 LEU SER ALA THR GLU LEU GLU GLN VAL LEU TYR PHE SER
SEQRES 11 N 1524 LYS TYR ILE VAL LEU ASP PRO LYS GLY ALA ILE LEU ASN
SEQRES 12 N 1524 GLY VAL PRO VAL GLU LYS ARG GLN LEU LEU THR ASP GLU
SEQRES 13 N 1524 GLU TYR ARG GLU LEU ARG TYR GLY LYS GLN GLU THR TYR
SEQRES 14 N 1524 PRO LEU PRO PRO GLY VAL ASP ALA LEU VAL LYS ASP GLY
SEQRES 15 N 1524 GLU GLU VAL VAL LYS GLY GLN GLU LEU ALA PRO GLY VAL
SEQRES 16 N 1524 VAL SER ARG LEU ASP GLY VAL ALA LEU TYR ARG PHE PRO
SEQRES 17 N 1524 ARG ARG VAL ARG VAL GLU TYR VAL LYS LYS GLU ARG ALA
SEQRES 18 N 1524 GLY LEU ARG LEU PRO LEU ALA ALA TRP VAL GLU LYS GLU
SEQRES 19 N 1524 ALA TYR LYS PRO GLY GLU ILE LEU ALA GLU LEU PRO GLU
SEQRES 20 N 1524 PRO TYR LEU PHE ARG ALA GLU GLU GLU GLY VAL VAL GLU
SEQRES 21 N 1524 LEU LYS GLU LEU GLU GLU GLY ALA PHE LEU VAL LEU ARG
SEQRES 22 N 1524 ARG GLU ASP GLU PRO VAL ALA THR TYR PHE LEU PRO VAL
SEQRES 23 N 1524 GLY MET THR PRO LEU VAL VAL HIS GLY GLU ILE VAL GLU
SEQRES 24 N 1524 LYS GLY GLN PRO LEU ALA GLU ALA LYS GLY LEU LEU ARG
SEQRES 25 N 1524 MET PRO ARG GLN VAL ARG ALA ALA GLN VAL GLU ALA GLU
SEQRES 26 N 1524 GLU GLU GLY GLU THR VAL TYR LEU THR LEU PHE LEU GLU
SEQRES 27 N 1524 TRP THR GLU PRO LYS ASP TYR ARG VAL GLN PRO HIS MET
SEQRES 28 N 1524 ASN VAL VAL VAL PRO GLU GLY ALA ARG VAL GLU ALA GLY
SEQRES 29 N 1524 ASP LYS ILE VAL ALA ALA ILE ASP PRO GLU GLU GLU VAL
SEQRES 30 N 1524 ILE ALA GLU ALA GLU GLY VAL VAL HIS LEU HIS GLU PRO
SEQRES 31 N 1524 ALA SER ILE LEU VAL VAL LYS ALA ARG VAL TYR PRO PHE
SEQRES 32 N 1524 GLU ASP ASP VAL GLU VAL SER THR GLY ASP ARG VAL ALA
SEQRES 33 N 1524 PRO GLY ASP VAL LEU ALA ASP GLY GLY LYS VAL LYS SER
SEQRES 34 N 1524 ASP VAL TYR GLY ARG VAL GLU VAL ASP LEU VAL ARG ASN
SEQRES 35 N 1524 VAL VAL ARG VAL VAL GLU SER TYR ASP ILE ASP ALA ARG
SEQRES 36 N 1524 MET GLY ALA GLU ALA ILE GLN GLN LEU LEU LYS GLU LEU
SEQRES 37 N 1524 ASP LEU GLU ALA LEU GLU LYS GLU LEU LEU GLU GLU MET
SEQRES 38 N 1524 LYS HIS PRO SER ARG ALA ARG ARG ALA LYS ALA ARG LYS
SEQRES 39 N 1524 ARG LEU GLU VAL VAL ARG ALA PHE LEU ASP SER GLY ASN
SEQRES 40 N 1524 ARG PRO GLU TRP MET ILE LEU GLU ALA VAL PRO VAL LEU
SEQRES 41 N 1524 PRO PRO ASP LEU ARG PRO MET VAL GLN VAL ASP GLY GLY
SEQRES 42 N 1524 ARG PHE ALA THR SER ASP LEU ASN ASP LEU TYR ARG ARG
SEQRES 43 N 1524 LEU ILE ASN ARG ASN ASN ARG LEU LYS LYS LEU LEU ALA
SEQRES 44 N 1524 GLN GLY ALA PRO GLU ILE ILE ILE ARG ASN GLU LYS ARG
SEQRES 45 N 1524 MET LEU GLN GLU ALA VAL ASP ALA LEU LEU ASP ASN GLY
SEQRES 46 N 1524 ARG ARG GLY ALA PRO VAL THR ASN PRO GLY SER ASP ARG
SEQRES 47 N 1524 PRO LEU ARG SER LEU THR ASP ILE LEU SER GLY LYS GLN
SEQRES 48 N 1524 GLY ARG PHE ARG GLN ASN LEU LEU GLY LYS ARG VAL ASP
SEQRES 49 N 1524 TYR SER GLY ARG SER VAL ILE VAL VAL GLY PRO GLN LEU
SEQRES 50 N 1524 LYS LEU HIS GLN CYS GLY LEU PRO LYS ARG MET ALA LEU
SEQRES 51 N 1524 GLU LEU PHE LYS PRO PHE LEU LEU LYS LYS MET GLU GLU
SEQRES 52 N 1524 LYS GLY ILE ALA PRO ASN VAL LYS ALA ALA ARG ARG MET
SEQRES 53 N 1524 LEU GLU ARG GLN ARG ASP ILE LYS ASP GLU VAL TRP ASP
SEQRES 54 N 1524 ALA LEU GLU GLU VAL ILE HIS GLY LYS VAL VAL LEU LEU
SEQRES 55 N 1524 ASN ARG ALA PRO THR LEU HIS ARG LEU GLY ILE GLN ALA
SEQRES 56 N 1524 PHE GLN PRO VAL LEU VAL GLU GLY GLN SER ILE GLN LEU
SEQRES 57 N 1524 HIS PRO LEU VAL CYS GLU ALA PHE ASN ALA ASP PHE ASP
SEQRES 58 N 1524 GLY ASP GLN MET ALA VAL HIS VAL PRO LEU SER SER PHE
SEQRES 59 N 1524 ALA GLN ALA GLU ALA ARG ILE GLN MET LEU SER ALA HIS
SEQRES 60 N 1524 ASN LEU LEU SER PRO ALA SER GLY GLU PRO LEU ALA LYS
SEQRES 61 N 1524 PRO SER ARG ASP ILE ILE LEU GLY LEU TYR TYR ILE THR
SEQRES 62 N 1524 GLN VAL ARG LYS GLU LYS LYS GLY ALA GLY LEU GLU PHE
SEQRES 63 N 1524 ALA THR PRO GLU GLU ALA LEU ALA ALA HIS GLU ARG GLY
SEQRES 64 N 1524 GLU VAL ALA LEU ASN ALA PRO ILE LYS VAL ALA GLY ARG
SEQRES 65 N 1524 GLU THR SER VAL GLY ARG LEU LYS TYR VAL PHE ALA ASN
SEQRES 66 N 1524 PRO ASP GLU ALA LEU LEU ALA VAL ALA HIS GLY ILE VAL
SEQRES 67 N 1524 ASP LEU GLN ASP VAL VAL THR VAL ARG TYR MET GLY LYS
SEQRES 68 N 1524 ARG LEU GLU THR SER PRO GLY ARG ILE LEU PHE ALA ARG
SEQRES 69 N 1524 ILE VAL ALA GLU ALA VAL GLU ASP GLU LYS VAL ALA TRP
SEQRES 70 N 1524 GLU LEU ILE GLN LEU ASP VAL PRO GLN GLU LYS ASN SER
SEQRES 71 N 1524 LEU LYS ASP LEU VAL TYR GLN ALA PHE LEU ARG LEU GLY
SEQRES 72 N 1524 MET GLU LYS THR ALA ARG LEU LEU ASP ALA LEU LYS TYR
SEQRES 73 N 1524 TYR GLY PHE THR PHE SER THR THR SER GLY ILE THR ILE
SEQRES 74 N 1524 GLY ILE ASP ASP ALA VAL ILE PRO GLU GLU LYS LYS GLN
SEQRES 75 N 1524 TYR LEU GLU GLU ALA ASP ARG LYS LEU LEU GLN ILE GLU
SEQRES 76 N 1524 GLN ALA TYR GLU MET GLY PHE LEU THR ASP ARG GLU ARG
SEQRES 77 N 1524 TYR ASP GLN ILE LEU GLN LEU TRP THR GLU THR THR GLU
SEQRES 78 N 1524 LYS VAL THR GLN ALA VAL PHE LYS ASN PHE GLU GLU ASN
SEQRES 79 N 1524 TYR PRO PHE ASN PRO LEU TYR VAL MET ALA GLN SER GLY
SEQRES 80 N 1524 ALA ARG GLY ASN PRO GLN GLN ILE ARG GLN LEU CYS GLY
SEQRES 81 N 1524 LEU ARG GLY LEU MET GLN LYS PRO SER GLY GLU THR PHE
SEQRES 82 N 1524 GLU VAL PRO VAL ARG SER SER PHE ARG GLU GLY LEU THR
SEQRES 83 N 1524 VAL LEU GLU TYR PHE ILE SER SER HIS GLY ALA ARG LYS
SEQRES 84 N 1524 GLY GLY ALA ASP THR ALA LEU ARG THR ALA ASP SER GLY
SEQRES 85 N 1524 TYR LEU THR ARG LYS LEU VAL ASP VAL THR HIS GLU ILE
SEQRES 86 N 1524 VAL VAL ARG GLU ALA ASP CYS GLY THR THR ASN TYR ILE
SEQRES 87 N 1524 SER VAL PRO LEU PHE GLN PRO ASP GLU VAL THR ARG SER
SEQRES 88 N 1524 LEU ARG LEU ARG LYS ARG ALA ASP ILE GLU ALA GLY LEU
SEQRES 89 N 1524 TYR GLY ARG VAL LEU ALA ARG GLU VAL GLU VAL LEU GLY
SEQRES 90 N 1524 VAL ARG LEU GLU GLU GLY ARG TYR LEU SER MET ASP ASP
SEQRES 91 N 1524 VAL HIS LEU LEU ILE LYS ALA ALA GLU ALA GLY GLU ILE
SEQRES 92 N 1524 GLN GLU VAL PRO VAL ARG SER PRO LEU THR CYS GLN THR
SEQRES 93 N 1524 ARG TYR GLY VAL CYS GLN LYS CYS TYR GLY TYR ASP LEU
SEQRES 94 N 1524 SER MET ALA ARG PRO VAL SER ILE GLY GLU ALA VAL GLY
SEQRES 95 N 1524 ILE VAL ALA ALA GLN SER ILE GLY GLU PRO GLY THR GLN
SEQRES 96 N 1524 LEU THR MET ARG THR PHE HIS THR GLY GLY VAL ALA GLY
SEQRES 97 N 1524 ALA ALA ASP ILE THR GLN GLY LEU PRO ARG VAL ILE GLU
SEQRES 98 N 1524 LEU PHE GLU ALA ARG ARG PRO LYS ALA LYS ALA VAL ILE
SEQRES 99 N 1524 SER GLU ILE ASP GLY VAL VAL ARG ILE GLU GLU THR GLU
SEQRES 100 N 1524 GLU LYS LEU SER VAL PHE VAL GLU SER GLU GLY PHE SER
SEQRES 101 N 1524 LYS GLU TYR LYS LEU PRO LYS GLU ALA ARG LEU LEU VAL
SEQRES 102 N 1524 LYS ASP GLY ASP TYR VAL GLU ALA GLY GLN PRO LEU THR
SEQRES 103 N 1524 ARG GLY ALA ILE ASP PRO HIS GLN LEU LEU GLU ALA LYS
SEQRES 104 N 1524 GLY PRO GLU ALA VAL GLU ARG TYR LEU VAL GLU GLU ILE
SEQRES 105 N 1524 GLN LYS VAL TYR ARG ALA GLN GLY VAL LYS LEU HIS ASP
SEQRES 106 N 1524 LYS HIS ILE GLU ILE VAL VAL ARG GLN MET MET LYS TYR
SEQRES 107 N 1524 VAL GLU VAL THR ASP PRO GLY ASP SER ARG LEU LEU GLU
SEQRES 108 N 1524 GLY GLN VAL LEU GLU LYS TRP ASP VAL GLU ALA LEU ASN
SEQRES 109 N 1524 GLU ARG LEU ILE ALA GLU GLY LYS THR PRO VAL ALA TRP
SEQRES 110 N 1524 LYS PRO LEU LEU MET GLY VAL THR LYS SER ALA LEU SER
SEQRES 111 N 1524 THR LYS SER TRP LEU SER ALA ALA SER PHE GLN ASN THR
SEQRES 112 N 1524 THR HIS VAL LEU THR GLU ALA ALA ILE ALA GLY LYS LYS
SEQRES 113 N 1524 ASP GLU LEU ILE GLY LEU LYS GLU ASN VAL ILE LEU GLY
SEQRES 114 N 1524 ARG LEU ILE PRO ALA GLY THR GLY SER ASP PHE VAL ARG
SEQRES 115 N 1524 PHE THR GLN VAL VAL ASP GLN LYS THR LEU LYS ALA ILE
SEQRES 116 N 1524 GLU GLU ALA ARG LYS GLU ALA VAL GLU ALA LYS GLU ARG
SEQRES 117 N 1524 PRO ALA ALA ARG ARG GLY VAL LYS ARG GLU GLN PRO GLY
SEQRES 118 N 1524 LYS GLN ALA
SEQRES 1 O 99 MET ALA GLU PRO GLY ILE ASP LYS LEU PHE GLY MET VAL
SEQRES 2 O 99 ASP SER LYS TYR ARG LEU THR VAL VAL VAL ALA LYS ARG
SEQRES 3 O 99 ALA GLN GLN LEU LEU ARG HIS GLY PHE LYS ASN THR VAL
SEQRES 4 O 99 LEU GLU PRO GLU GLU ARG PRO LYS MET GLN THR LEU GLU
SEQRES 5 O 99 GLY LEU PHE ASP ASP PRO ASN ALA VAL THR TRP ALA MET
SEQRES 6 O 99 LYS GLU LEU LEU THR GLY ARG LEU VAL PHE GLY GLU ASN
SEQRES 7 O 99 LEU VAL PRO GLU ASP ARG LEU GLN LYS GLU MET GLU ARG
SEQRES 8 O 99 LEU TYR PRO VAL GLU ARG GLU GLU
SEQRES 1 P 423 MET LYS LYS SER LYS ARG LYS ASN ALA GLN ALA GLN GLU
SEQRES 2 P 423 ALA GLN GLU THR GLU VAL LEU VAL GLN GLU GLU ALA GLU
SEQRES 3 P 423 GLU LEU PRO GLU PHE PRO GLU GLY GLU PRO ASP PRO ASP
SEQRES 4 P 423 LEU GLU ASP PRO ASP LEU ALA LEU GLU ASP ASP LEU LEU
SEQRES 5 P 423 ASP LEU PRO GLU GLU GLY GLU GLY LEU ASP LEU GLU GLU
SEQRES 6 P 423 GLU GLU GLU ASP LEU PRO ILE PRO LYS ILE SER THR SER
SEQRES 7 P 423 ASP PRO VAL ARG GLN TYR LEU HIS GLU ILE GLY GLN VAL
SEQRES 8 P 423 PRO LEU LEU THR LEU GLU GLU GLU VAL GLU LEU ALA ARG
SEQRES 9 P 423 LYS VAL GLU GLU GLY MET GLU ALA ILE LYS LYS LEU SER
SEQRES 10 P 423 GLU ILE THR GLY LEU ASP PRO ASP LEU ILE ARG GLU VAL
SEQRES 11 P 423 VAL ARG ALA LYS ILE LEU GLY SER ALA ARG VAL ARG HIS
SEQRES 12 P 423 ILE PRO GLY LEU LYS GLU THR LEU ASP PRO LYS THR VAL
SEQRES 13 P 423 GLU GLU ILE ASP GLN LYS LEU LYS SER LEU PRO LYS GLU
SEQRES 14 P 423 HIS LYS ARG TYR LEU HIS ILE ALA ARG GLU GLY GLU ALA
SEQRES 15 P 423 ALA ARG GLN HIS LEU ILE GLU ALA ASN LEU ARG LEU VAL
SEQRES 16 P 423 VAL SER ILE ALA LYS LYS TYR THR GLY ARG GLY LEU SER
SEQRES 17 P 423 PHE LEU ASP LEU ILE GLN GLU GLY ASN GLN GLY LEU ILE
SEQRES 18 P 423 ARG ALA VAL GLU LYS PHE GLU TYR LYS ARG ARG PHE LYS
SEQRES 19 P 423 PHE SER THR TYR ALA THR TRP TRP ILE ARG GLN ALA ILE
SEQRES 20 P 423 ASN ARG ALA ILE ALA ASP GLN ALA ARG THR ILE ARG ILE
SEQRES 21 P 423 PRO VAL HIS MET VAL GLU THR ILE ASN LYS LEU SER ARG
SEQRES 22 P 423 THR ALA ARG GLN LEU GLN GLN GLU LEU GLY ARG GLU PRO
SEQRES 23 P 423 THR TYR GLU GLU ILE ALA GLU ALA MET GLY PRO GLY TRP
SEQRES 24 P 423 ASP ALA LYS ARG VAL GLU GLU THR LEU LYS ILE ALA GLN
SEQRES 25 P 423 GLU PRO VAL SER LEU GLU THR PRO ILE GLY ASP GLU LYS
SEQRES 26 P 423 ASP SER PHE TYR GLY ASP PHE ILE PRO ASP GLU HIS LEU
SEQRES 27 P 423 PRO SER PRO VAL ASP ALA ALA THR GLN SER LEU LEU SER
SEQRES 28 P 423 GLU GLU LEU GLU LYS ALA LEU SER LYS LEU SER GLU ARG
SEQRES 29 P 423 GLU ALA MET VAL LEU LYS LEU ARG LYS GLY LEU ILE ASP
SEQRES 30 P 423 GLY ARG GLU HIS THR LEU GLU GLU VAL GLY ALA PHE PHE
SEQRES 31 P 423 GLY VAL THR ARG GLU ARG ILE ARG GLN ILE GLU ASN LYS
SEQRES 32 P 423 ALA LEU ARG LYS LEU LYS TYR HIS GLU SER ARG THR ARG
SEQRES 33 P 423 LYS LEU ARG ASP PHE LEU ASP
HET ZN D1525 1
HET ZN D1526 1
HET MXP D1527 30
HET MG D1528 1
HET ZN N1525 1
HET ZN N1526 1
HET MXP N1527 30
HET MG N1528 1
HETNAM ZN ZINC ION
HETNAM MXP MYXOPYRONIN B
HETNAM MG MAGNESIUM ION
HETSYN MXP METHYL [(1E)-5-{3-[(2E,4E)-2,5-DIMETHYLNONA-2,4-
HETSYN 2 MXP DIENOYL]-4-HYDROXY-2-OXO-2H-PYRAN-6-YL}PENT-1-EN-1-
HETSYN 3 MXP YL]CARBAMATE
FORMUL 13 ZN 4(ZN 2+)
FORMUL 15 MXP 2(C23 H31 N O6)
FORMUL 16 MG 2(MG 2+)
FORMUL 21 HOH *4496(H2 O)
HELIX 1 1 PHE A 32 SER A 47 1 16
HELIX 2 2 ASP A 74 GLU A 84 1 11
HELIX 3 3 ARG A 112 PHE A 114 5 3
HELIX 4 4 PRO A 152 GLY A 157 1 6
HELIX 5 5 THR A 206 TYR A 224 1 19
HELIX 6 6 PHE B 32 SER B 47 1 16
HELIX 7 7 ASP B 74 GLU B 84 1 11
HELIX 8 8 ARG B 112 PHE B 114 5 3
HELIX 9 9 PRO B 152 GLY B 157 1 6
HELIX 10 10 THR B 206 TYR B 224 1 19
HELIX 11 11 THR C 19 LEU C 30 1 12
HELIX 12 12 VAL C 42 PHE C 52 1 11
HELIX 13 13 PRO C 79 LYS C 86 1 8
HELIX 14 14 PRO C 192 GLY C 201 1 10
HELIX 15 15 ASP C 203 ALA C 213 1 11
HELIX 16 16 LEU C 217 MET C 222 1 6
HELIX 17 17 GLU C 224 MET C 229 1 6
HELIX 18 18 ARG C 230 LEU C 242 1 13
HELIX 19 19 LYS C 252 TYR C 258 1 7
HELIX 20 20 GLY C 273 GLU C 279 1 7
HELIX 21 21 VAL C 302 GLY C 316 1 15
HELIX 22 22 THR C 335 GLY C 362 1 28
HELIX 23 23 THR C 368 VAL C 373 1 6
HELIX 24 24 SER C 375 SER C 389 1 15
HELIX 25 25 ASN C 399 ARG C 408 1 10
HELIX 26 26 GLY C 424 ASP C 429 1 6
HELIX 27 27 HIS C 431 TYR C 435 5 5
HELIX 28 28 THR C 489 TYR C 494 1 6
HELIX 29 29 SER C 535 PHE C 540 5 6
HELIX 30 30 SER C 541 LEU C 546 1 6
HELIX 31 31 PHE C 549 ASP C 553 5 5
HELIX 32 32 ASP C 554 THR C 566 1 13
HELIX 33 33 LEU C 583 SER C 591 1 9
HELIX 34 34 GLU C 692 ARG C 697 1 6
HELIX 35 35 THR C 768 GLY C 779 1 12
HELIX 36 36 ASN C 872 VAL C 876 5 5
HELIX 37 37 LEU C 882 LEU C 897 1 16
HELIX 38 38 LYS C 910 GLU C 932 1 23
HELIX 39 39 ASP C 937 LYS C 949 1 13
HELIX 40 40 THR C 958 GLN C 969 1 12
HELIX 41 41 GLY C 1033 TYR C 1043 1 11
HELIX 42 42 ALA C 1045 THR C 1054 1 10
HELIX 43 43 ASP C 1059 LYS C 1072 1 14
HELIX 44 44 PRO C 1082 LEU C 1095 1 14
HELIX 45 45 SER D 14 TRP D 21 1 8
HELIX 46 46 SER D 83 ARG D 89 1 7
HELIX 47 47 HIS D 101 LYS D 106 1 6
HELIX 48 48 SER D 110 LEU D 116 1 7
HELIX 49 49 THR D 121 SER D 130 1 10
HELIX 50 50 THR D 154 TYR D 163 1 10
HELIX 51 51 ASP D 423 LYS D 426 5 4
HELIX 52 52 GLY D 457 LEU D 468 1 12
HELIX 53 53 ASP D 469 HIS D 483 1 15
HELIX 54 54 SER D 485 SER D 505 1 21
HELIX 55 55 ARG D 508 TRP D 511 5 4
HELIX 56 56 ASP D 539 GLY D 561 1 23
HELIX 57 57 PRO D 563 ASP D 583 1 21
HELIX 58 58 SER D 602 GLN D 611 1 10
HELIX 59 59 PRO D 645 PHE D 653 1 9
HELIX 60 60 PHE D 653 LYS D 664 1 12
HELIX 61 61 ASN D 669 LEU D 677 1 9
HELIX 62 62 LYS D 684 ILE D 695 1 12
HELIX 63 63 HIS D 709 LEU D 711 5 3
HELIX 64 64 PRO D 730 GLU D 734 5 5
HELIX 65 65 SER D 752 MET D 763 1 12
HELIX 66 66 LEU D 764 ASN D 768 5 5
HELIX 67 67 SER D 782 GLN D 794 1 13
HELIX 68 68 PRO D 809 ALA D 822 1 14
HELIX 69 69 SER D 835 TYR D 841 1 7
HELIX 70 70 ASN D 845 HIS D 855 1 11
HELIX 71 71 SER D 876 VAL D 890 1 15
HELIX 72 72 ASP D 892 LEU D 899 1 8
HELIX 73 73 GLU D 907 LEU D 922 1 16
HELIX 74 74 GLY D 923 GLY D 946 1 24
HELIX 75 75 GLY D 950 ALA D 954 5 5
HELIX 76 76 GLU D 958 GLU D 979 1 22
HELIX 77 77 THR D 984 ASN D 1014 1 31
HELIX 78 78 ASN D 1018 SER D 1026 1 9
HELIX 79 79 ASN D 1031 CYS D 1039 1 9
HELIX 80 80 THR D 1066 HIS D 1103 1 38
HELIX 81 81 LYS D 1136 TYR D 1145 1 10
HELIX 82 82 ASP D 1169 GLY D 1181 1 13
HELIX 83 83 SER D 1190 CYS D 1194 5 5
HELIX 84 84 CYS D 1201 GLY D 1206 1 6
HELIX 85 85 ALA D 1220 GLU D 1231 1 12
HELIX 86 86 PRO D 1232 LEU D 1236 5 5
HELIX 87 87 GLY D 1255 GLU D 1264 1 10
HELIX 88 88 ASP D 1331 LYS D 1339 1 9
HELIX 89 89 GLY D 1340 GLY D 1360 1 21
HELIX 90 90 HIS D 1364 GLN D 1374 1 11
HELIX 91 91 LEU D 1395 ILE D 1408 1 14
HELIX 92 92 GLY D 1423 SER D 1430 1 8
HELIX 93 93 SER D 1433 PHE D 1440 1 8
HELIX 94 94 THR D 1443 ALA D 1453 1 11
HELIX 95 95 GLY D 1461 LEU D 1468 1 8
HELIX 96 96 ASP D 1488 GLU D 1501 1 14
HELIX 97 97 GLY E 5 VAL E 13 1 9
HELIX 98 98 SER E 15 HIS E 33 1 19
HELIX 99 99 GLY E 34 THR E 38 5 5
HELIX 100 100 ASN E 59 LEU E 69 1 11
HELIX 101 101 ASP E 83 TYR E 93 1 11
HELIX 102 102 THR F 77 VAL F 91 1 15
HELIX 103 103 THR F 95 GLY F 121 1 27
HELIX 104 104 ASP F 123 GLY F 137 1 15
HELIX 105 105 SER F 138 ILE F 144 1 7
HELIX 106 106 LEU F 151 LEU F 166 1 16
HELIX 107 107 PRO F 167 ASN F 191 1 25
HELIX 108 108 ASN F 191 LYS F 200 1 10
HELIX 109 109 LYS F 201 GLY F 206 5 6
HELIX 110 110 SER F 208 PHE F 227 1 20
HELIX 111 111 LYS F 234 ALA F 255 1 22
HELIX 112 112 PRO F 261 GLY F 283 1 23
HELIX 113 113 THR F 287 GLY F 296 1 10
HELIX 114 114 ASP F 300 ALA F 311 1 12
HELIX 115 115 TYR F 329 ILE F 333 5 5
HELIX 116 116 SER F 340 LEU F 361 1 22
HELIX 117 117 SER F 362 ARG F 372 1 11
HELIX 118 118 GLU F 384 PHE F 389 1 6
HELIX 119 119 THR F 393 THR F 415 1 23
HELIX 120 120 GLY K 31 SER K 47 1 17
HELIX 121 121 ASP K 74 GLU K 84 1 11
HELIX 122 122 ARG K 112 PHE K 114 5 3
HELIX 123 123 PRO K 152 GLY K 157 1 6
HELIX 124 124 THR K 206 TYR K 224 1 19
HELIX 125 125 GLY L 31 SER L 47 1 17
HELIX 126 126 ASP L 74 GLU L 84 1 11
HELIX 127 127 ARG L 112 PHE L 114 5 3
HELIX 128 128 THR L 206 TYR L 224 1 19
HELIX 129 129 THR M 19 LEU M 30 1 12
HELIX 130 130 VAL M 42 PHE M 52 1 11
HELIX 131 131 PRO M 79 LYS M 86 1 8
HELIX 132 132 PRO M 192 GLY M 201 1 10
HELIX 133 133 ASP M 203 ALA M 213 1 11
HELIX 134 134 LEU M 217 MET M 222 1 6
HELIX 135 135 GLU M 224 MET M 229 1 6
HELIX 136 136 ARG M 230 LEU M 242 1 13
HELIX 137 137 ALA M 253 TYR M 258 1 6
HELIX 138 138 GLY M 273 GLU M 279 1 7
HELIX 139 139 VAL M 302 GLY M 316 1 15
HELIX 140 140 THR M 335 GLY M 362 1 28
HELIX 141 141 SER M 375 SER M 389 1 15
HELIX 142 142 ASN M 399 ARG M 408 1 10
HELIX 143 143 GLY M 424 ASP M 429 1 6
HELIX 144 144 HIS M 431 TYR M 435 5 5
HELIX 145 145 THR M 489 TYR M 494 1 6
HELIX 146 146 SER M 535 PHE M 540 5 6
HELIX 147 147 SER M 541 LEU M 546 1 6
HELIX 148 148 PHE M 549 ASP M 553 5 5
HELIX 149 149 ASP M 554 THR M 566 1 13
HELIX 150 150 LEU M 583 SER M 591 1 9
HELIX 151 151 GLU M 692 ARG M 697 1 6
HELIX 152 152 THR M 768 GLY M 779 1 12
HELIX 153 153 ASN M 872 VAL M 876 5 5
HELIX 154 154 LEU M 882 LEU M 897 1 16
HELIX 155 155 LYS M 910 GLU M 932 1 23
HELIX 156 156 ASP M 937 LYS M 949 1 13
HELIX 157 157 THR M 958 GLN M 969 1 12
HELIX 158 158 GLY M 1033 TYR M 1043 1 11
HELIX 159 159 ALA M 1045 THR M 1054 1 10
HELIX 160 160 ASP M 1059 LYS M 1072 1 14
HELIX 161 161 PRO M 1082 LEU M 1095 1 14
HELIX 162 162 SER N 14 TRP N 21 1 8
HELIX 163 163 SER N 83 ARG N 89 1 7
HELIX 164 164 HIS N 101 LYS N 106 1 6
HELIX 165 165 SER N 110 LEU N 116 1 7
HELIX 166 166 THR N 121 SER N 130 1 10
HELIX 167 167 THR N 154 TYR N 163 1 10
HELIX 168 168 ASP N 423 LYS N 426 5 4
HELIX 169 169 GLY N 457 LEU N 468 1 12
HELIX 170 170 ASP N 469 HIS N 483 1 15
HELIX 171 171 SER N 485 SER N 505 1 21
HELIX 172 172 ARG N 508 TRP N 511 5 4
HELIX 173 173 ASP N 539 GLY N 561 1 23
HELIX 174 174 PRO N 563 ASP N 583 1 21
HELIX 175 175 SER N 602 GLN N 611 1 10
HELIX 176 176 PRO N 645 PHE N 653 1 9
HELIX 177 177 PHE N 653 LYS N 664 1 12
HELIX 178 178 ASN N 669 LEU N 677 1 9
HELIX 179 179 LYS N 684 ILE N 695 1 12
HELIX 180 180 HIS N 709 LEU N 711 5 3
HELIX 181 181 PRO N 730 GLU N 734 5 5
HELIX 182 182 SER N 752 MET N 763 1 12
HELIX 183 183 LEU N 764 ASN N 768 5 5
HELIX 184 184 SER N 782 GLN N 794 1 13
HELIX 185 185 PRO N 809 ALA N 822 1 14
HELIX 186 186 SER N 835 TYR N 841 1 7
HELIX 187 187 ASN N 845 HIS N 855 1 11
HELIX 188 188 SER N 876 VAL N 890 1 15
HELIX 189 189 ASP N 892 LEU N 899 1 8
HELIX 190 190 GLU N 907 LEU N 922 1 16
HELIX 191 191 GLY N 923 GLY N 946 1 24
HELIX 192 192 GLY N 950 ALA N 954 5 5
HELIX 193 193 GLU N 958 GLU N 979 1 22
HELIX 194 194 THR N 984 ASN N 1014 1 31
HELIX 195 195 ASN N 1018 SER N 1026 1 9
HELIX 196 196 ASN N 1031 CYS N 1039 1 9
HELIX 197 197 THR N 1066 HIS N 1103 1 38
HELIX 198 198 LYS N 1136 TYR N 1145 1 10
HELIX 199 199 ASP N 1169 GLY N 1181 1 13
HELIX 200 200 SER N 1190 CYS N 1194 5 5
HELIX 201 201 CYS N 1201 GLY N 1206 1 6
HELIX 202 202 ALA N 1220 GLU N 1231 1 12
HELIX 203 203 PRO N 1232 LEU N 1236 5 5
HELIX 204 204 GLY N 1255 GLU N 1264 1 10
HELIX 205 205 ASP N 1331 LYS N 1339 1 9
HELIX 206 206 GLY N 1340 GLY N 1360 1 21
HELIX 207 207 HIS N 1364 GLN N 1374 1 11
HELIX 208 208 LEU N 1395 ILE N 1408 1 14
HELIX 209 209 GLY N 1423 SER N 1430 1 8
HELIX 210 210 SER N 1433 PHE N 1440 1 8
HELIX 211 211 THR N 1443 ALA N 1453 1 11
HELIX 212 212 GLY N 1461 LEU N 1468 1 8
HELIX 213 213 ASP N 1488 GLU N 1501 1 14
HELIX 214 214 GLY O 5 VAL O 13 1 9
HELIX 215 215 SER O 15 HIS O 33 1 19
HELIX 216 216 GLY O 34 THR O 38 5 5
HELIX 217 217 ASN O 59 LEU O 69 1 11
HELIX 218 218 ASP O 83 TYR O 93 1 11
HELIX 219 219 THR P 77 VAL P 91 1 15
HELIX 220 220 THR P 95 GLY P 121 1 27
HELIX 221 221 ASP P 123 GLY P 137 1 15
HELIX 222 222 SER P 138 ILE P 144 1 7
HELIX 223 223 LEU P 151 LEU P 166 1 16
HELIX 224 224 PRO P 167 ASN P 191 1 25
HELIX 225 225 ASN P 191 LYS P 200 1 10
HELIX 226 226 TYR P 202 GLY P 206 5 5
HELIX 227 227 SER P 208 PHE P 227 1 20
HELIX 228 228 LYS P 234 ALA P 255 1 22
HELIX 229 229 PRO P 261 GLY P 283 1 23
HELIX 230 230 THR P 287 GLY P 296 1 10
HELIX 231 231 ASP P 300 ALA P 311 1 12
HELIX 232 232 PHE P 328 PHE P 332 5 5
HELIX 233 233 SER P 340 LEU P 361 1 22
HELIX 234 234 SER P 362 ARG P 372 1 11
HELIX 235 235 GLU P 384 PHE P 389 1 6
HELIX 236 236 THR P 393 THR P 415 1 23
SHEET 1 A 4 PHE A 11 THR A 15 0
SHEET 2 A 4 TYR A 20 LEU A 28 -1 O VAL A 24 N THR A 12
SHEET 3 A 4 ASP A 193 THR A 201 -1 O ASP A 193 N LEU A 28
SHEET 4 A 4 VAL A 174 ASP A 183 -1 N ALA A 178 O ARG A 198
SHEET 1 B 4 THR A 96 LYS A 102 0
SHEET 2 B 4 ASN A 139 GLY A 147 -1 O VAL A 144 N VAL A 97
SHEET 3 B 4 GLY A 50 ILE A 58 -1 N GLY A 50 O GLY A 147
SHEET 4 B 4 ILE A 165 PRO A 166 -1 O ILE A 165 N VAL A 56
SHEET 1 C 2 VAL A 87 PHE A 89 0
SHEET 2 C 2 VAL A 120 ILE A 122 -1 O GLU A 121 N ARG A 88
SHEET 1 D 2 GLU A 108 LYS A 110 0
SHEET 2 D 2 HIS A 128 THR A 131 -1 O ILE A 129 N VAL A 109
SHEET 1 E 2 TYR A 150 VAL A 151 0
SHEET 2 E 2 ALA A 169 VAL A 170 -1 O ALA A 169 N VAL A 151
SHEET 1 F 4 VAL B 10 THR B 15 0
SHEET 2 F 4 TYR B 20 LEU B 28 -1 O GLU B 22 N ARG B 14
SHEET 3 F 4 ASP B 193 THR B 201 -1 O ASP B 193 N LEU B 28
SHEET 4 F 4 VAL B 174 VAL B 181 -1 N ALA B 178 O ARG B 198
SHEET 1 G 4 THR B 96 LYS B 102 0
SHEET 2 G 4 ASN B 139 GLY B 147 -1 O VAL B 144 N VAL B 97
SHEET 3 G 4 GLY B 50 ILE B 58 -1 N GLY B 50 O GLY B 147
SHEET 4 G 4 ILE B 165 PRO B 166 -1 O ILE B 165 N VAL B 56
SHEET 1 H 2 VAL B 87 PHE B 89 0
SHEET 2 H 2 VAL B 120 ILE B 122 -1 O GLU B 121 N ARG B 88
SHEET 1 I 2 GLU B 108 LYS B 110 0
SHEET 2 I 2 HIS B 128 THR B 131 -1 O ALA B 130 N VAL B 109
SHEET 1 J 2 TYR B 150 VAL B 151 0
SHEET 2 J 2 ALA B 169 VAL B 170 -1 O ALA B 169 N VAL B 151
SHEET 1 K 3 ILE C 3 LYS C 4 0
SHEET 2 K 3 ARG C 900 ILE C 902 1 O ILE C 902 N LYS C 4
SHEET 3 K 3 VAL C 579 MET C 580 1 N MET C 580 O TYR C 901
SHEET 1 L 4 ILE C 54 GLU C 56 0
SHEET 2 L 4 LEU C 64 LEU C 73 -1 O LEU C 64 N GLU C 56
SHEET 3 L 4 GLN C 91 ILE C 101 -1 O ILE C 101 N VAL C 65
SHEET 4 L 4 HIS C 117 PRO C 119 -1 O ILE C 118 N ALA C 92
SHEET 1 M 2 ARG C 134 ILE C 136 0
SHEET 2 M 2 SER C 392 PHE C 394 -1 O GLN C 393 N VAL C 135
SHEET 1 N 4 ARG C 331 ARG C 334 0
SHEET 2 N 4 SER C 138 ARG C 142 -1 N GLN C 139 O ARG C 334
SHEET 3 N 4 ARG C 409 SER C 411 1 O SER C 411 N SER C 138
SHEET 4 N 4 THR C 453 SER C 454 -1 O THR C 453 N ILE C 410
SHEET 1 O 4 VAL C 146 THR C 149 0
SHEET 2 O 4 ILE C 159 ILE C 162 -1 O SER C 161 N TYR C 147
SHEET 3 O 4 ILE C 172 GLU C 177 -1 O ILE C 172 N ILE C 162
SHEET 4 O 4 VAL C 181 LYS C 185 -1 O SER C 183 N GLU C 175
SHEET 1 P 3 ARG C 460 VAL C 461 0
SHEET 2 P 3 ILE C 467 ARG C 473 -1 O ARG C 468 N ARG C 460
SHEET 3 P 3 VAL C 484 MET C 486 -1 O VAL C 484 N TYR C 471
SHEET 1 Q 6 ARG C 460 VAL C 461 0
SHEET 2 Q 6 ILE C 467 ARG C 473 -1 O ARG C 468 N ARG C 460
SHEET 3 Q 6 PHE C 531 ASP C 533 -1 O MET C 532 N ARG C 472
SHEET 4 Q 6 ILE C 496 ALA C 497 1 N ALA C 497 O ASP C 533
SHEET 5 Q 6 VAL C 513 ARG C 516 -1 O ARG C 516 N ILE C 496
SHEET 6 Q 6 PRO C 521 VAL C 524 -1 O VAL C 522 N ALA C 515
SHEET 1 R 3 LEU C 595 TYR C 596 0
SHEET 2 R 3 LEU C 654 ASP C 657 -1 O LEU C 655 N LEU C 595
SHEET 3 R 3 ARG C 640 PRO C 641 -1 N ARG C 640 O ASP C 657
SHEET 1 S 4 LEU C 620 PRO C 624 0
SHEET 2 S 4 ARG C 610 TYR C 615 -1 N VAL C 613 O VAL C 621
SHEET 3 S 4 GLY C 601 VAL C 606 -1 N GLU C 602 O ARG C 614
SHEET 4 S 4 ARG C 648 VAL C 649 -1 O VAL C 649 N GLY C 601
SHEET 1 T 2 TYR C 629 ARG C 630 0
SHEET 2 T 2 ALA C 636 LEU C 637 -1 O LEU C 637 N TYR C 629
SHEET 1 U 8 LYS C 971 VAL C 972 0
SHEET 2 U 8 ILE C 987 LYS C 996 -1 O ILE C 987 N VAL C 972
SHEET 3 U 8 LYS C 838 ALA C 840 -1 N ALA C 840 O MET C 995
SHEET 4 U 8 LYS C 846 LEU C 853 -1 O GLY C 847 N LEU C 839
SHEET 5 U 8 ALA C 687 SER C 691 1 N ILE C 688 O ALA C 850
SHEET 6 U 8 VAL C 869 ILE C 870 -1 O ILE C 870 N VAL C 689
SHEET 7 U 8 GLN C 670 ALA C 675 1 O LEU C 673 N VAL C 869
SHEET 8 U 8 ILE C 987 LYS C 996 -1 O GLY C 990 N VAL C 674
SHEET 1 V 3 THR C 701 ARG C 713 0
SHEET 2 V 3 VAL C 819 LYS C 832 -1 O GLN C 829 N HIS C 704
SHEET 3 V 3 ILE C 799 LEU C 806 -1 N ILE C 799 O ALA C 828
SHEET 1 W 2 THR C 759 PHE C 761 0
SHEET 2 W 2 VAL C 785 ASP C 787 -1 O LYS C 786 N SER C 760
SHEET 1 X 6 HIS C1006 ARG C1008 0
SHEET 2 X 6 SER D 626 VAL D 633 -1 O SER D 626 N ARG C1008
SHEET 3 X 6 GLN D 744 HIS D 748 -1 O VAL D 747 N GLY D 627
SHEET 4 X 6 VAL D 700 ASN D 703 -1 N ASN D 703 O ALA D 746
SHEET 5 X 6 ILE D 713 PRO D 718 -1 O GLN D 714 N LEU D 702
SHEET 6 X 6 GLN D 641 CYS D 642 1 N CYS D 642 O GLN D 717
SHEET 1 Y 3 HIS C1006 ARG C1008 0
SHEET 2 Y 3 SER D 626 VAL D 633 -1 O SER D 626 N ARG C1008
SHEET 3 Y 3 ILE D 726 LEU D 728 1 O ILE D 726 N VAL D 632
SHEET 1 Z 2 GLN C1030 PHE C1032 0
SHEET 2 Z 2 LYS D 621 VAL D 623 -1 O LYS D 621 N PHE C1032
SHEET 1 AA 3 ASP C1098 LEU C1102 0
SHEET 2 AA 3 LYS D 7 ALA D 11 -1 O ALA D 11 N ASP C1098
SHEET 3 AA 3 LYS D1456 GLU D1458 -1 O ASP D1457 N VAL D 8
SHEET 1 AB 3 SER D 22 GLU D 25 0
SHEET 2 AB 3 MET D 90 ALA D 100 1 O HIS D 92 N GLY D 24
SHEET 3 AB 3 ILE D 513 VAL D 519 -1 O VAL D 519 N GLY D 91
SHEET 1 AC 2 ILE D 32 ASN D 33 0
SHEET 2 AC 2 LYS D 38 PRO D 39 -1 O LYS D 38 N ASN D 33
SHEET 1 AD 3 LEU D 152 LEU D 153 0
SHEET 2 AD 3 ILE D 133 LEU D 135 -1 N ILE D 133 O LEU D 153
SHEET 3 AD 3 ALA D 454 ARG D 455 -1 O ARG D 455 N VAL D 134
SHEET 1 AE 3 GLN D 166 TYR D 169 0
SHEET 2 AE 3 ILE D 393 VAL D 396 -1 O ILE D 393 N TYR D 169
SHEET 3 AE 3 ALA D 203 TYR D 205 -1 N LEU D 204 O LEU D 394
SHEET 1 AF 2 VAL D 420 ALA D 422 0
SHEET 2 AF 2 VAL D 427 LYS D 428 -1 O VAL D 427 N LEU D 421
SHEET 1 AG 2 VAL D 435 GLU D 436 0
SHEET 2 AG 2 ARG D 445 VAL D 446 -1 O ARG D 445 N GLU D 436
SHEET 1 AH 3 MET D 527 GLN D 529 0
SHEET 2 AH 3 PHE D 535 THR D 537 -1 O ALA D 536 N VAL D 528
SHEET 3 AH 3 VAL F 315 SER F 316 1 O VAL F 315 N PHE D 535
SHEET 1 AI 3 VAL D 842 PHE D 843 0
SHEET 2 AI 3 THR D 865 ARG D 867 1 O THR D 865 N PHE D 843
SHEET 3 AI 3 ARG D 872 GLU D 874 -1 O LEU D 873 N VAL D 866
SHEET 1 AJ 4 ILE D1118 SER D1119 0
SHEET 2 AJ 4 PRO D1187 ARG D1189 -1 O VAL D1188 N ILE D1118
SHEET 3 AJ 4 ARG D1147 LEU D1149 -1 N VAL D1148 O ARG D1189
SHEET 4 AJ 4 TYR D1165 LEU D1166 -1 O LEU D1166 N ARG D1147
SHEET 1 AK 2 PHE D1123 GLN D1124 0
SHEET 2 AK 2 ARG D1133 LEU D1134 -1 O ARG D1133 N GLN D1124
SHEET 1 AL 2 VAL D1153 GLU D1154 0
SHEET 2 AL 2 ARG D1159 LEU D1160 -1 O LEU D1160 N VAL D1153
SHEET 1 AM 4 SER D1300 LEU D1305 0
SHEET 2 AM 4 LEU D1290 GLU D1295 -1 N VAL D1294 O LYS D1301
SHEET 3 AM 4 GLY D1279 ILE D1283 -1 N ARG D1282 O PHE D1293
SHEET 4 AM 4 TYR D1318 VAL D1319 -1 O VAL D1319 N GLY D1279
SHEET 1 AN 3 GLY D1392 VAL D1394 0
SHEET 2 AN 3 TYR D1378 ASP D1383 -1 N VAL D1379 O GLN D1393
SHEET 3 AN 3 ALA D1416 PRO D1419 -1 O ALA D1416 N THR D1382
SHEET 1 AO 2 GLN D1485 VAL D1487 0
SHEET 2 AO 2 VAL E 74 GLY E 76 -1 O GLY E 76 N GLN D1485
SHEET 1 AP 4 PHE K 11 THR K 15 0
SHEET 2 AP 4 TYR K 20 LEU K 28 -1 O VAL K 24 N THR K 12
SHEET 3 AP 4 ASP K 193 THR K 201 -1 O ASP K 193 N LEU K 28
SHEET 4 AP 4 VAL K 174 VAL K 181 -1 N ALA K 178 O ARG K 198
SHEET 1 AQ 4 THR K 96 LYS K 102 0
SHEET 2 AQ 4 ASN K 139 VAL K 148 -1 O VAL K 144 N VAL K 97
SHEET 3 AQ 4 PRO K 49 ILE K 58 -1 N GLY K 50 O GLY K 147
SHEET 4 AQ 4 ILE K 165 PRO K 166 -1 O ILE K 165 N VAL K 56
SHEET 1 AR 2 VAL K 87 PHE K 89 0
SHEET 2 AR 2 VAL K 120 ILE K 122 -1 O GLU K 121 N ARG K 88
SHEET 1 AS 2 GLU K 108 LYS K 110 0
SHEET 2 AS 2 HIS K 128 THR K 131 -1 O ILE K 129 N VAL K 109
SHEET 1 AT 2 TYR K 150 VAL K 151 0
SHEET 2 AT 2 ALA K 169 VAL K 170 -1 O ALA K 169 N VAL K 151
SHEET 1 AU 4 THR L 12 THR L 15 0
SHEET 2 AU 4 TYR L 20 LEU L 28 -1 O VAL L 24 N THR L 12
SHEET 3 AU 4 ASP L 193 THR L 201 -1 O ASP L 193 N LEU L 28
SHEET 4 AU 4 VAL L 174 VAL L 181 -1 N ALA L 178 O ARG L 198
SHEET 1 AV 4 THR L 96 LYS L 102 0
SHEET 2 AV 4 ASN L 139 GLY L 147 -1 O VAL L 144 N VAL L 97
SHEET 3 AV 4 GLY L 50 ILE L 58 -1 N THR L 54 O ARG L 143
SHEET 4 AV 4 ILE L 165 PRO L 166 -1 O ILE L 165 N VAL L 56
SHEET 1 AW 2 VAL L 87 PHE L 89 0
SHEET 2 AW 2 VAL L 120 ILE L 122 -1 O GLU L 121 N ARG L 88
SHEET 1 AX 2 GLU L 108 LYS L 110 0
SHEET 2 AX 2 HIS L 128 THR L 131 -1 O ILE L 129 N VAL L 109
SHEET 1 AY 2 TYR L 150 VAL L 151 0
SHEET 2 AY 2 ALA L 169 VAL L 170 -1 O ALA L 169 N VAL L 151
SHEET 1 AZ 3 ILE M 3 LYS M 4 0
SHEET 2 AZ 3 ARG M 900 ILE M 902 1 O ARG M 900 N LYS M 4
SHEET 3 AZ 3 VAL M 579 MET M 580 1 N MET M 580 O TYR M 901
SHEET 1 BA 4 ILE M 54 GLU M 56 0
SHEET 2 BA 4 LEU M 64 LEU M 73 -1 O LEU M 64 N GLU M 56
SHEET 3 BA 4 GLN M 91 ILE M 101 -1 O ILE M 101 N VAL M 65
SHEET 4 BA 4 HIS M 117 PRO M 119 -1 O ILE M 118 N ALA M 92
SHEET 1 BB 2 ARG M 134 ILE M 136 0
SHEET 2 BB 2 SER M 392 PHE M 394 -1 O GLN M 393 N VAL M 135
SHEET 1 BC 2 GLN M 139 ARG M 142 0
SHEET 2 BC 2 ARG M 331 ARG M 334 -1 O ARG M 332 N HIS M 141
SHEET 1 BD 4 VAL M 146 THR M 149 0
SHEET 2 BD 4 ILE M 159 ILE M 162 -1 O SER M 161 N TYR M 147
SHEET 3 BD 4 ILE M 172 GLU M 177 -1 O ILE M 172 N ILE M 162
SHEET 4 BD 4 VAL M 181 LYS M 185 -1 O SER M 183 N GLU M 175
SHEET 1 BE 2 ARG M 409 ILE M 410 0
SHEET 2 BE 2 THR M 453 SER M 454 -1 O THR M 453 N ILE M 410
SHEET 1 BF 3 ARG M 460 VAL M 461 0
SHEET 2 BF 3 ILE M 467 ARG M 473 -1 O ARG M 468 N ARG M 460
SHEET 3 BF 3 VAL M 484 MET M 486 -1 O VAL M 484 N TYR M 471
SHEET 1 BG 6 ARG M 460 VAL M 461 0
SHEET 2 BG 6 ILE M 467 ARG M 473 -1 O ARG M 468 N ARG M 460
SHEET 3 BG 6 PHE M 531 ASP M 533 -1 O MET M 532 N ARG M 472
SHEET 4 BG 6 ILE M 496 ALA M 497 1 N ALA M 497 O ASP M 533
SHEET 5 BG 6 VAL M 513 ARG M 516 -1 O ARG M 516 N ILE M 496
SHEET 6 BG 6 PRO M 521 VAL M 524 -1 O VAL M 522 N ALA M 515
SHEET 1 BH 3 LEU M 595 TYR M 596 0
SHEET 2 BH 3 LEU M 654 ASP M 657 -1 O LEU M 655 N LEU M 595
SHEET 3 BH 3 ARG M 640 PRO M 641 -1 N ARG M 640 O ASP M 657
SHEET 1 BI 4 LEU M 620 PRO M 624 0
SHEET 2 BI 4 ARG M 610 TYR M 615 -1 N VAL M 613 O VAL M 621
SHEET 3 BI 4 GLY M 601 VAL M 606 -1 N GLU M 602 O ARG M 614
SHEET 4 BI 4 ARG M 648 VAL M 649 -1 O VAL M 649 N GLY M 601
SHEET 1 BJ 2 TYR M 629 ARG M 630 0
SHEET 2 BJ 2 ALA M 636 LEU M 637 -1 O LEU M 637 N TYR M 629
SHEET 1 BK 8 LYS M 971 VAL M 972 0
SHEET 2 BK 8 ILE M 987 LYS M 996 -1 O ILE M 987 N VAL M 972
SHEET 3 BK 8 LYS M 838 ALA M 840 -1 N ALA M 840 O MET M 995
SHEET 4 BK 8 LYS M 846 LEU M 853 -1 O GLY M 847 N LEU M 839
SHEET 5 BK 8 ALA M 687 SER M 691 1 N ILE M 690 O LYS M 851
SHEET 6 BK 8 VAL M 869 ILE M 870 -1 O ILE M 870 N VAL M 689
SHEET 7 BK 8 GLN M 670 ALA M 675 1 O LEU M 673 N VAL M 869
SHEET 8 BK 8 ILE M 987 LYS M 996 -1 O MET M 992 N VAL M 672
SHEET 1 BL 3 THR M 701 ARG M 713 0
SHEET 2 BL 3 VAL M 819 LYS M 832 -1 O GLU M 821 N ALA M 712
SHEET 3 BL 3 ILE M 799 LEU M 806 -1 N ILE M 799 O ALA M 828
SHEET 1 BM 2 THR M 759 PHE M 761 0
SHEET 2 BM 2 VAL M 785 ASP M 787 -1 O LYS M 786 N SER M 760
SHEET 1 BN 6 HIS M1006 ARG M1008 0
SHEET 2 BN 6 SER N 626 VAL N 633 -1 O SER N 626 N ARG M1008
SHEET 3 BN 6 GLN N 744 HIS N 748 -1 O VAL N 747 N GLY N 627
SHEET 4 BN 6 VAL N 700 ASN N 703 -1 N ASN N 703 O ALA N 746
SHEET 5 BN 6 ILE N 713 PRO N 718 -1 O GLN N 714 N LEU N 702
SHEET 6 BN 6 GLN N 641 CYS N 642 1 N CYS N 642 O GLN N 717
SHEET 1 BO 3 HIS M1006 ARG M1008 0
SHEET 2 BO 3 SER N 626 VAL N 633 -1 O SER N 626 N ARG M1008
SHEET 3 BO 3 ILE N 726 LEU N 728 1 O ILE N 726 N VAL N 632
SHEET 1 BP 2 GLN M1030 PHE M1032 0
SHEET 2 BP 2 LYS N 621 VAL N 623 -1 O LYS N 621 N PHE M1032
SHEET 1 BQ 3 ASP M1098 LEU M1102 0
SHEET 2 BQ 3 LYS N 7 ALA N 11 -1 O LYS N 7 N LEU M1102
SHEET 3 BQ 3 LYS N1456 GLU N1458 -1 O ASP N1457 N VAL N 8
SHEET 1 BR 3 SER N 22 GLU N 25 0
SHEET 2 BR 3 MET N 90 ALA N 100 1 O HIS N 92 N GLY N 24
SHEET 3 BR 3 ILE N 513 VAL N 519 -1 O VAL N 519 N GLY N 91
SHEET 1 BS 2 ILE N 32 ASN N 33 0
SHEET 2 BS 2 LYS N 38 PRO N 39 -1 O LYS N 38 N ASN N 33
SHEET 1 BT 2 VAL N 134 LEU N 135 0
SHEET 2 BT 2 ALA N 454 ARG N 455 -1 O ARG N 455 N VAL N 134
SHEET 1 BU 3 GLN N 166 TYR N 169 0
SHEET 2 BU 3 ILE N 393 VAL N 396 -1 O ILE N 393 N TYR N 169
SHEET 3 BU 3 ALA N 203 TYR N 205 -1 N LEU N 204 O LEU N 394
SHEET 1 BV 2 VAL N 420 ALA N 422 0
SHEET 2 BV 2 VAL N 427 LYS N 428 -1 O VAL N 427 N LEU N 421
SHEET 1 BW 2 VAL N 435 GLU N 436 0
SHEET 2 BW 2 ARG N 445 VAL N 446 -1 O ARG N 445 N GLU N 436
SHEET 1 BX 3 MET N 527 GLN N 529 0
SHEET 2 BX 3 PHE N 535 THR N 537 -1 O ALA N 536 N VAL N 528
SHEET 3 BX 3 VAL P 315 SER P 316 1 O VAL P 315 N PHE N 535
SHEET 1 BY 3 VAL N 842 PHE N 843 0
SHEET 2 BY 3 THR N 865 ARG N 867 1 O THR N 865 N PHE N 843
SHEET 3 BY 3 ARG N 872 GLU N 874 -1 O LEU N 873 N VAL N 866
SHEET 1 BZ 4 ILE N1118 SER N1119 0
SHEET 2 BZ 4 PRO N1187 ARG N1189 -1 O VAL N1188 N ILE N1118
SHEET 3 BZ 4 ARG N1147 LEU N1149 -1 N VAL N1148 O ARG N1189
SHEET 4 BZ 4 TYR N1165 LEU N1166 -1 O LEU N1166 N ARG N1147
SHEET 1 CA 2 PHE N1123 GLN N1124 0
SHEET 2 CA 2 ARG N1133 LEU N1134 -1 O ARG N1133 N GLN N1124
SHEET 1 CB 2 VAL N1153 GLU N1154 0
SHEET 2 CB 2 ARG N1159 LEU N1160 -1 O LEU N1160 N VAL N1153
SHEET 1 CC 4 SER N1300 LEU N1305 0
SHEET 2 CC 4 LEU N1290 GLU N1295 -1 N VAL N1294 O LYS N1301
SHEET 3 CC 4 GLY N1279 ILE N1283 -1 N ARG N1282 O PHE N1293
SHEET 4 CC 4 TYR N1318 VAL N1319 -1 O VAL N1319 N GLY N1279
SHEET 1 CD 3 GLY N1392 VAL N1394 0
SHEET 2 CD 3 TYR N1378 ASP N1383 -1 N VAL N1379 O GLN N1393
SHEET 3 CD 3 ALA N1416 PRO N1419 -1 O ALA N1416 N THR N1382
SHEET 1 CE 2 GLN N1485 VAL N1487 0
SHEET 2 CE 2 VAL O 74 GLY O 76 -1 O GLY O 76 N GLN N1485
LINK SG CYS D 58 ZN ZN D1525 1555 1555 2.38
LINK SG CYS D 60 ZN ZN D1525 1555 1555 2.33
LINK SG CYS D 73 ZN ZN D1525 1555 1555 2.33
LINK SG CYS D 76 ZN ZN D1525 1555 1555 2.41
LINK OD2 ASP D 739 MG MG D1528 1555 1555 2.17
LINK OD2 ASP D 741 MG MG D1528 1555 1555 2.09
LINK OD1 ASP D 743 MG MG D1528 1555 1555 2.14
LINK SG CYS D1112 ZN ZN D1526 1555 1555 2.27
LINK SG CYS D1194 ZN ZN D1526 1555 1555 2.31
LINK SG CYS D1201 ZN ZN D1526 1555 1555 2.33
LINK SG CYS D1204 ZN ZN D1526 1555 1555 2.30
LINK SG CYS N 58 ZN ZN N1525 1555 1555 2.41
LINK SG CYS N 60 ZN ZN N1525 1555 1555 2.31
LINK SG CYS N 73 ZN ZN N1525 1555 1555 2.30
LINK SG CYS N 76 ZN ZN N1525 1555 1555 2.38
LINK OD2 ASP N 739 MG MG N1528 1555 1555 2.21
LINK OD1 ASP N 741 MG MG N1528 1555 1555 2.26
LINK OD2 ASP N 741 MG MG N1528 1555 1555 2.23
LINK OD1 ASP N 743 MG MG N1528 1555 1555 2.23
LINK SG CYS N1112 ZN ZN N1526 1555 1555 2.26
LINK SG CYS N1194 ZN ZN N1526 1555 1555 2.30
LINK SG CYS N1201 ZN ZN N1526 1555 1555 2.37
LINK SG CYS N1204 ZN ZN N1526 1555 1555 2.36
CISPEP 1 GLU B 26 PRO B 27 0 -6.71
CISPEP 2 LEU C 165 PRO C 166 0 0.90
CISPEP 3 GLU L 26 PRO L 27 0 1.41
CISPEP 4 LEU M 165 PRO M 166 0 1.05
SITE 1 AC1 5 CYS D 58 CYS D 60 CYS D 73 CYS D 76
SITE 2 AC1 5 HOH D1539
SITE 1 AC2 4 CYS D1112 CYS D1194 CYS D1201 CYS D1204
SITE 1 AC3 12 GLU C1034 TRP C1038 GLU C1041 SER C1084
SITE 2 AC3 12 LEU C1088 LYS D 610 GLN D 611 LEU D 619
SITE 3 AC3 12 GLY D 620 LYS D1463 VAL D1466 ILE D1467
SITE 1 AC4 3 ASP D 739 ASP D 741 ASP D 743
SITE 1 AC5 4 CYS N 58 CYS N 60 CYS N 73 CYS N 76
SITE 1 AC6 5 CYS N1112 CYS N1194 CYS N1201 CYS N1204
SITE 2 AC6 5 HOH N1595
SITE 1 AC7 14 GLU M1034 VAL M1037 TRP M1038 GLU M1041
SITE 2 AC7 14 SER M1084 LYS N 610 GLN N 611 LEU N 619
SITE 3 AC7 14 ALA N1438 LYS N1463 VAL N1466 ILE N1467
SITE 4 AC7 14 HOH N1557 HOH N1677
SITE 1 AC8 3 ASP N 739 ASP N 741 ASP N 743
CRYST1 235.001 235.001 254.947 90.00 90.00 120.00 P 32 12
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.004255 0.002457 0.000000 0.00000
SCALE2 0.000000 0.004914 0.000000 0.00000
SCALE3 0.000000 0.000000 0.003922 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
