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Database: PDB
Entry: 3J9T
LinkDB: 3J9T
Original site: 3J9T 
HEADER    HYDROLASE                               23-FEB-15   3J9T              
TITLE     YEAST V-ATPASE STATE 1                                                
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT D;                            
COMPND   3 CHAIN: M;                                                            
COMPND   4 SYNONYM: V-ATPASE SUBUNIT D, VACUOLAR PROTON PUMP SUBUNIT D;         
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT F;                            
COMPND   7 CHAIN: N;                                                            
COMPND   8 SYNONYM: V-ATPASE SUBUNIT F, V-ATPASE 14 KDA SUBUNIT, VACUOLAR PROTON
COMPND   9 PUMP SUBUNIT F;                                                      
COMPND  10 MOL_ID: 3;                                                           
COMPND  11 MOLECULE: V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A;                  
COMPND  12 CHAIN: A, C, E;                                                      
COMPND  13 FRAGMENT: SEE REMARK 999;                                            
COMPND  14 SYNONYM: V-ATPASE SUBUNIT A, VACUOLAR PROTON PUMP SUBUNIT A,         
COMPND  15 ENDONUCLEASE PI-SCEI, SCE VMA INTEIN, VMA1-DERIVED ENDONUCLEASE, VDE;
COMPND  16 EC: 3.6.3.14, 3.1.-.-;                                               
COMPND  17 MOL_ID: 4;                                                           
COMPND  18 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT B;                            
COMPND  19 CHAIN: B, D, F;                                                      
COMPND  20 SYNONYM: V-ATPASE SUBUNIT B, V-ATPASE 57 KDA SUBUNIT, VACUOLAR PROTON
COMPND  21 PUMP SUBUNIT B;                                                      
COMPND  22 MOL_ID: 5;                                                           
COMPND  23 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT D;                            
COMPND  24 CHAIN: Q;                                                            
COMPND  25 SYNONYM: V-ATPASE SUBUNIT D, V-ATPASE 39 KDA SUBUNIT, V-ATPASE       
COMPND  26 SUBUNIT M39, VACUOLAR PROTON PUMP SUBUNIT D;                         
COMPND  27 MOL_ID: 6;                                                           
COMPND  28 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT G;                            
COMPND  29 CHAIN: L, H, J;                                                      
COMPND  30 SYNONYM: V-ATPASE SUBUNIT G, V-ATPASE 13 KDA SUBUNIT, VACUOLAR PROTON
COMPND  31 PUMP SUBUNIT G;                                                      
COMPND  32 MOL_ID: 7;                                                           
COMPND  33 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT E;                            
COMPND  34 CHAIN: K, G, I;                                                      
COMPND  35 SYNONYM: V-ATPASE SUBUNIT E, V-ATPASE 27 KDA SUBUNIT, VACUOLAR PROTON
COMPND  36 PUMP SUBUNIT E;                                                      
COMPND  37 MOL_ID: 8;                                                           
COMPND  38 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT H;                            
COMPND  39 CHAIN: P;                                                            
COMPND  40 SYNONYM: V-ATPASE SUBUNIT H, V-ATPASE 54 KDA SUBUNIT, VACUOLAR PROTON
COMPND  41 PUMP SUBUNIT H;                                                      
COMPND  42 MOL_ID: 9;                                                           
COMPND  43 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM;          
COMPND  44 CHAIN: b;                                                            
COMPND  45 SYNONYM: V-ATPASE A 1 SUBUNIT, V-ATPASE 95 KDA SUBUNIT, VACUOLAR PH  
COMPND  46 PROTEIN 1, VACUOLAR PROTON PUMP A SUBUNIT, VACUOLAR PROTON           
COMPND  47 TRANSLOCATING ATPASE SUBUNIT A 1;                                    
COMPND  48 MOL_ID: 10;                                                          
COMPND  49 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT C;                            
COMPND  50 CHAIN: O;                                                            
COMPND  51 SYNONYM: V-ATPASE SUBUNIT C, V-ATPASE 42 KDA SUBUNIT, VACUOLAR PROTON
COMPND  52 PUMP SUBUNIT C;                                                      
COMPND  53 MOL_ID: 11;                                                          
COMPND  54 MOLECULE: V-TYPE PROTON ATPASE SUBUNIT C;                            
COMPND  55 CHAIN: Y, R, U, V, T, W, S, X, Z, a;                                 
COMPND  56 SYNONYM: V-ATPASE SUBUNIT C, GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, V-
COMPND  57 ATPASE 16 KDA PROTEOLIPID SUBUNIT 1, VACUOLAR PROTON PUMP C SUBUNIT  
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: YEAST;                                              
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 STRAIN: SABY31;                                                      
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   8 ORGANISM_COMMON: YEAST;                                              
SOURCE   9 ORGANISM_TAXID: 4932;                                                
SOURCE  10 STRAIN: SABY31;                                                      
SOURCE  11 MOL_ID: 3;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  13 ORGANISM_COMMON: YEAST;                                              
SOURCE  14 ORGANISM_TAXID: 4932;                                                
SOURCE  15 STRAIN: SABY31;                                                      
SOURCE  16 MOL_ID: 4;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  18 ORGANISM_COMMON: YEAST;                                              
SOURCE  19 ORGANISM_TAXID: 4932;                                                
SOURCE  20 STRAIN: SABY31;                                                      
SOURCE  21 MOL_ID: 5;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  23 ORGANISM_COMMON: YEAST;                                              
SOURCE  24 ORGANISM_TAXID: 4932;                                                
SOURCE  25 STRAIN: SABY31;                                                      
SOURCE  26 MOL_ID: 6;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  28 ORGANISM_COMMON: YEAST;                                              
SOURCE  29 ORGANISM_TAXID: 4932;                                                
SOURCE  30 STRAIN: SABY31;                                                      
SOURCE  31 MOL_ID: 7;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  33 ORGANISM_COMMON: YEAST;                                              
SOURCE  34 ORGANISM_TAXID: 4932;                                                
SOURCE  35 STRAIN: SABY31;                                                      
SOURCE  36 MOL_ID: 8;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  38 ORGANISM_COMMON: YEAST;                                              
SOURCE  39 ORGANISM_TAXID: 4932;                                                
SOURCE  40 STRAIN: SABY31;                                                      
SOURCE  41 MOL_ID: 9;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  43 ORGANISM_COMMON: YEAST;                                              
SOURCE  44 ORGANISM_TAXID: 4932;                                                
SOURCE  45 STRAIN: SABY31;                                                      
SOURCE  46 MOL_ID: 10;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  48 ORGANISM_COMMON: YEAST;                                              
SOURCE  49 ORGANISM_TAXID: 4932;                                                
SOURCE  50 STRAIN: SABY31;                                                      
SOURCE  51 MOL_ID: 11;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  53 ORGANISM_COMMON: YEAST;                                              
SOURCE  54 ORGANISM_TAXID: 4932;                                                
SOURCE  55 STRAIN: SABY31                                                       
KEYWDS    V-ATPASE, V-TYPE ATPASE, VACUOLAR-TYPE ATPASE, PROTON PUMP, HYDROLASE 
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.ZHAO,S.BENLEKBIR,J.L.RUBINSTEIN                                     
REVDAT   3   03-JUN-15 3J9T    1       JRNL                                     
REVDAT   2   20-MAY-15 3J9T    1       JRNL                                     
REVDAT   1   13-MAY-15 3J9T    0                                                
JRNL        AUTH   J.ZHAO,S.BENLEKBIR,J.L.RUBINSTEIN                            
JRNL        TITL   ELECTRON CRYOMICROSCOPY OBSERVATION OF ROTATIONAL STATES IN  
JRNL        TITL 2 A EUKARYOTIC V-ATPASE.                                       
JRNL        REF    NATURE                        V. 521   241 2015              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   25971514                                                     
JRNL        DOI    10.1038/NATURE14365                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    6.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : TMACS                                     
REMARK   3   RECONSTRUCTION SCHEMA  : MAXIMUM LIKELIHOOD                        
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 1U7L                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE                            
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 1.450                          
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : 1.450                          
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 6.900                          
REMARK   3   NUMBER OF PARTICLES               : 50503                          
REMARK   3   CTF CORRECTION METHOD             : EACH PARTICLE                  
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: (SINGLE PARTICLE DETAILS: PARTICLES AUTOMATICALLY     
REMARK   3  SELECTED USING TMACS AND PROCESSED IN RELION.) (SINGLE PARTICLE--   
REMARK   3  APPLIED SYMMETRY: C1)                                               
REMARK   4                                                                      
REMARK   4 3J9T COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 05-MAR-15.                  
REMARK 100 THE RCSB ID CODE IS RCSB160431.                                      
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE (CRYO EM)            
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : ASYMMETRIC                        
REMARK 245   NAME OF SAMPLE                 : VACUOLAR-TYPE ATPASE              
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 10.00                             
REMARK 245   SAMPLE SUPPORT DETAILS         : HOMEMADE HOLEY CARBON ON 400      
REMARK 245                                    SQUARE MESH CU/RH GRID, GLOW-     
REMARK 245                                    DISCHARGED 2 MINS                 
REMARK 245   SAMPLE VITRIFICATION DETAILS   : BLOT FOR 23 SECONDS BEFORE        
REMARK 245                                    FREEZING IN ETHANE/PROPANE        
REMARK 245                                    MIXTURE (FEI VITROBOT MARK III).  
REMARK 245   SAMPLE BUFFER                  : 50 MM TRIS-HCL, 150 MM NACL,      
REMARK 245                                    0.02% W/V DODECYLMALTOSIDE        
REMARK 245   PH                             : 7.40                              
REMARK 245   SAMPLE DETAILS                 : DETERGENT-SOLUBILIZED PROTEIN     
REMARK 245  COMPLEX                                                             
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 19-OCT-13                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 3685                           
REMARK 245   TEMPERATURE (KELVIN)              : 77.00                          
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI F20                 
REMARK 245   DETECTOR TYPE                     : GATAN K2 (4K X 4K)             
REMARK 245   MINIMUM DEFOCUS (NM)              : 1500.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 7000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 30.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 34483                          
REMARK 245   CALIBRATED MAGNIFICATION          : 34483                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : K2 SUMMIT IN COUNTING MODE,    
REMARK 245  2 FRAMES/S FOR 15 S                                                 
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 28-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: M, N, A, B, C, D, E, F, Q,            
REMARK 350                    AND CHAINS: L, K, P, b, O, H, G, J, I,            
REMARK 350                    AND CHAINS: Y, R, U, V, T, W, S, X, Z, a          
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET M     1                                                      
REMARK 465     SER M     2                                                      
REMARK 465     GLY M     3                                                      
REMARK 465     ASN M     4                                                      
REMARK 465     ARG M     5                                                      
REMARK 465     GLU M     6                                                      
REMARK 465     GLN M     7                                                      
REMARK 465     ASP M   218                                                      
REMARK 465     ALA M   219                                                      
REMARK 465     GLU M   220                                                      
REMARK 465     MET M   221                                                      
REMARK 465     LYS M   222                                                      
REMARK 465     LEU M   223                                                      
REMARK 465     LYS M   224                                                      
REMARK 465     ARG M   225                                                      
REMARK 465     ASP M   226                                                      
REMARK 465     ARG M   227                                                      
REMARK 465     ALA M   228                                                      
REMARK 465     GLU M   229                                                      
REMARK 465     GLN M   230                                                      
REMARK 465     ASP M   231                                                      
REMARK 465     ALA M   232                                                      
REMARK 465     SER M   233                                                      
REMARK 465     GLU M   234                                                      
REMARK 465     VAL M   235                                                      
REMARK 465     ALA M   236                                                      
REMARK 465     ALA M   237                                                      
REMARK 465     ASP M   238                                                      
REMARK 465     GLU M   239                                                      
REMARK 465     GLU M   240                                                      
REMARK 465     PRO M   241                                                      
REMARK 465     GLN M   242                                                      
REMARK 465     GLY M   243                                                      
REMARK 465     GLU M   244                                                      
REMARK 465     THR M   245                                                      
REMARK 465     LEU M   246                                                      
REMARK 465     VAL M   247                                                      
REMARK 465     ALA M   248                                                      
REMARK 465     ASP M   249                                                      
REMARK 465     GLN M   250                                                      
REMARK 465     GLU M   251                                                      
REMARK 465     ASP M   252                                                      
REMARK 465     ASP M   253                                                      
REMARK 465     VAL M   254                                                      
REMARK 465     ILE M   255                                                      
REMARK 465     PHE M   256                                                      
REMARK 465     MET N     1                                                      
REMARK 465     GLY N   117                                                      
REMARK 465     GLU N   118                                                      
REMARK 465     ALA A     1                                                      
REMARK 465     GLY A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     ILE A     4                                                      
REMARK 465     GLU A     5                                                      
REMARK 465     ASN A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     LYS A     9                                                      
REMARK 465     GLU A    10                                                      
REMARK 465     ILE A    11                                                      
REMARK 465     LYS A    12                                                      
REMARK 465     ARG A    13                                                      
REMARK 465     ILE A    14                                                      
REMARK 465     SER A    15                                                      
REMARK 465     LEU A    16                                                      
REMARK 465     GLU A    17                                                      
REMARK 465     ASP A    18                                                      
REMARK 465     HIS A    19                                                      
REMARK 465     ALA A    20                                                      
REMARK 465     GLU A    21                                                      
REMARK 465     SER A    22                                                      
REMARK 465     GLU A    23                                                      
REMARK 465     MET B     1                                                      
REMARK 465     VAL B     2                                                      
REMARK 465     LEU B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     ASP B     5                                                      
REMARK 465     LYS B     6                                                      
REMARK 465     GLU B     7                                                      
REMARK 465     LEU B     8                                                      
REMARK 465     PHE B     9                                                      
REMARK 465     ALA B    10                                                      
REMARK 465     ILE B    11                                                      
REMARK 465     ASN B    12                                                      
REMARK 465     LYS B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     ALA B    15                                                      
REMARK 465     VAL B    16                                                      
REMARK 465     GLU B    17                                                      
REMARK 465     GLN B    18                                                      
REMARK 465     GLY B    19                                                      
REMARK 465     PHE B    20                                                      
REMARK 465     ASN B    21                                                      
REMARK 465     VAL B    22                                                      
REMARK 465     LYS B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     ARG B    25                                                      
REMARK 465     LEU B    26                                                      
REMARK 465     ASN B    27                                                      
REMARK 465     TYR B    28                                                      
REMARK 465     ASP B   486                                                      
REMARK 465     ARG B   487                                                      
REMARK 465     ALA B   488                                                      
REMARK 465     ARG B   489                                                      
REMARK 465     ASP B   490                                                      
REMARK 465     ASP B   491                                                      
REMARK 465     ALA B   492                                                      
REMARK 465     ASP B   493                                                      
REMARK 465     GLU B   494                                                      
REMARK 465     ASP B   495                                                      
REMARK 465     GLU B   496                                                      
REMARK 465     GLU B   497                                                      
REMARK 465     ASP B   498                                                      
REMARK 465     PRO B   499                                                      
REMARK 465     ASP B   500                                                      
REMARK 465     THR B   501                                                      
REMARK 465     ARG B   502                                                      
REMARK 465     SER B   503                                                      
REMARK 465     SER B   504                                                      
REMARK 465     GLY B   505                                                      
REMARK 465     LYS B   506                                                      
REMARK 465     LYS B   507                                                      
REMARK 465     LYS B   508                                                      
REMARK 465     ASP B   509                                                      
REMARK 465     ALA B   510                                                      
REMARK 465     SER B   511                                                      
REMARK 465     GLN B   512                                                      
REMARK 465     GLU B   513                                                      
REMARK 465     GLU B   514                                                      
REMARK 465     SER B   515                                                      
REMARK 465     LEU B   516                                                      
REMARK 465     ILE B   517                                                      
REMARK 465     ALA C     1                                                      
REMARK 465     GLY C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     ILE C     4                                                      
REMARK 465     GLU C     5                                                      
REMARK 465     ASN C     6                                                      
REMARK 465     ALA C     7                                                      
REMARK 465     ARG C     8                                                      
REMARK 465     LYS C     9                                                      
REMARK 465     GLU C    10                                                      
REMARK 465     ILE C    11                                                      
REMARK 465     LYS C    12                                                      
REMARK 465     ARG C    13                                                      
REMARK 465     ILE C    14                                                      
REMARK 465     SER C    15                                                      
REMARK 465     LEU C    16                                                      
REMARK 465     GLU C    17                                                      
REMARK 465     ASP C    18                                                      
REMARK 465     HIS C    19                                                      
REMARK 465     ALA C    20                                                      
REMARK 465     GLU C    21                                                      
REMARK 465     SER C    22                                                      
REMARK 465     GLU C    23                                                      
REMARK 465     MET D     1                                                      
REMARK 465     VAL D     2                                                      
REMARK 465     LEU D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     ASP D     5                                                      
REMARK 465     LYS D     6                                                      
REMARK 465     GLU D     7                                                      
REMARK 465     LEU D     8                                                      
REMARK 465     PHE D     9                                                      
REMARK 465     ALA D    10                                                      
REMARK 465     ILE D    11                                                      
REMARK 465     ASN D    12                                                      
REMARK 465     LYS D    13                                                      
REMARK 465     LYS D    14                                                      
REMARK 465     ALA D    15                                                      
REMARK 465     VAL D    16                                                      
REMARK 465     GLU D    17                                                      
REMARK 465     GLN D    18                                                      
REMARK 465     GLY D    19                                                      
REMARK 465     PHE D    20                                                      
REMARK 465     ASN D    21                                                      
REMARK 465     VAL D    22                                                      
REMARK 465     LYS D    23                                                      
REMARK 465     PRO D    24                                                      
REMARK 465     ARG D    25                                                      
REMARK 465     LEU D    26                                                      
REMARK 465     ASN D    27                                                      
REMARK 465     TYR D    28                                                      
REMARK 465     ASP D   486                                                      
REMARK 465     ARG D   487                                                      
REMARK 465     ALA D   488                                                      
REMARK 465     ARG D   489                                                      
REMARK 465     ASP D   490                                                      
REMARK 465     ASP D   491                                                      
REMARK 465     ALA D   492                                                      
REMARK 465     ASP D   493                                                      
REMARK 465     GLU D   494                                                      
REMARK 465     ASP D   495                                                      
REMARK 465     GLU D   496                                                      
REMARK 465     GLU D   497                                                      
REMARK 465     ASP D   498                                                      
REMARK 465     PRO D   499                                                      
REMARK 465     ASP D   500                                                      
REMARK 465     THR D   501                                                      
REMARK 465     ARG D   502                                                      
REMARK 465     SER D   503                                                      
REMARK 465     SER D   504                                                      
REMARK 465     GLY D   505                                                      
REMARK 465     LYS D   506                                                      
REMARK 465     LYS D   507                                                      
REMARK 465     LYS D   508                                                      
REMARK 465     ASP D   509                                                      
REMARK 465     ALA D   510                                                      
REMARK 465     SER D   511                                                      
REMARK 465     GLN D   512                                                      
REMARK 465     GLU D   513                                                      
REMARK 465     GLU D   514                                                      
REMARK 465     SER D   515                                                      
REMARK 465     LEU D   516                                                      
REMARK 465     ILE D   517                                                      
REMARK 465     ALA E     1                                                      
REMARK 465     GLY E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     ILE E     4                                                      
REMARK 465     GLU E     5                                                      
REMARK 465     ASN E     6                                                      
REMARK 465     ALA E     7                                                      
REMARK 465     ARG E     8                                                      
REMARK 465     LYS E     9                                                      
REMARK 465     GLU E    10                                                      
REMARK 465     ILE E    11                                                      
REMARK 465     LYS E    12                                                      
REMARK 465     ARG E    13                                                      
REMARK 465     ILE E    14                                                      
REMARK 465     SER E    15                                                      
REMARK 465     LEU E    16                                                      
REMARK 465     GLU E    17                                                      
REMARK 465     ASP E    18                                                      
REMARK 465     HIS E    19                                                      
REMARK 465     ALA E    20                                                      
REMARK 465     GLU E    21                                                      
REMARK 465     SER E    22                                                      
REMARK 465     GLU E    23                                                      
REMARK 465     MET F     1                                                      
REMARK 465     VAL F     2                                                      
REMARK 465     LEU F     3                                                      
REMARK 465     SER F     4                                                      
REMARK 465     ASP F     5                                                      
REMARK 465     LYS F     6                                                      
REMARK 465     GLU F     7                                                      
REMARK 465     LEU F     8                                                      
REMARK 465     PHE F     9                                                      
REMARK 465     ALA F    10                                                      
REMARK 465     ILE F    11                                                      
REMARK 465     ASN F    12                                                      
REMARK 465     LYS F    13                                                      
REMARK 465     LYS F    14                                                      
REMARK 465     ALA F    15                                                      
REMARK 465     VAL F    16                                                      
REMARK 465     GLU F    17                                                      
REMARK 465     GLN F    18                                                      
REMARK 465     GLY F    19                                                      
REMARK 465     PHE F    20                                                      
REMARK 465     ASN F    21                                                      
REMARK 465     VAL F    22                                                      
REMARK 465     LYS F    23                                                      
REMARK 465     PRO F    24                                                      
REMARK 465     ARG F    25                                                      
REMARK 465     LEU F    26                                                      
REMARK 465     ASN F    27                                                      
REMARK 465     TYR F    28                                                      
REMARK 465     ASP F   486                                                      
REMARK 465     ARG F   487                                                      
REMARK 465     ALA F   488                                                      
REMARK 465     ARG F   489                                                      
REMARK 465     ASP F   490                                                      
REMARK 465     ASP F   491                                                      
REMARK 465     ALA F   492                                                      
REMARK 465     ASP F   493                                                      
REMARK 465     GLU F   494                                                      
REMARK 465     ASP F   495                                                      
REMARK 465     GLU F   496                                                      
REMARK 465     GLU F   497                                                      
REMARK 465     ASP F   498                                                      
REMARK 465     PRO F   499                                                      
REMARK 465     ASP F   500                                                      
REMARK 465     THR F   501                                                      
REMARK 465     ARG F   502                                                      
REMARK 465     SER F   503                                                      
REMARK 465     SER F   504                                                      
REMARK 465     GLY F   505                                                      
REMARK 465     LYS F   506                                                      
REMARK 465     LYS F   507                                                      
REMARK 465     LYS F   508                                                      
REMARK 465     ASP F   509                                                      
REMARK 465     ALA F   510                                                      
REMARK 465     SER F   511                                                      
REMARK 465     GLN F   512                                                      
REMARK 465     GLU F   513                                                      
REMARK 465     GLU F   514                                                      
REMARK 465     SER F   515                                                      
REMARK 465     LEU F   516                                                      
REMARK 465     ILE F   517                                                      
REMARK 465     MET L     1                                                      
REMARK 465     ALA L   107                                                      
REMARK 465     GLU L   108                                                      
REMARK 465     VAL L   109                                                      
REMARK 465     HIS L   110                                                      
REMARK 465     ILE L   111                                                      
REMARK 465     ASN L   112                                                      
REMARK 465     ALA L   113                                                      
REMARK 465     LEU L   114                                                      
REMARK 465     MET K     1                                                      
REMARK 465     SER K     2                                                      
REMARK 465     SER K     3                                                      
REMARK 465     ALA K     4                                                      
REMARK 465     ILE K     5                                                      
REMARK 465     THR K     6                                                      
REMARK 465     ALA K     7                                                      
REMARK 465     PRO K   225                                                      
REMARK 465     SER K   226                                                      
REMARK 465     LYS K   227                                                      
REMARK 465     THR K   228                                                      
REMARK 465     ARG K   229                                                      
REMARK 465     LYS K   230                                                      
REMARK 465     PHE K   231                                                      
REMARK 465     PHE K   232                                                      
REMARK 465     ASP K   233                                                      
REMARK 465     ILE P    56                                                      
REMARK 465     GLY P    57                                                      
REMARK 465     ASP P    58                                                      
REMARK 465     GLY P    59                                                      
REMARK 465     LEU P    60                                                      
REMARK 465     SER P    61                                                      
REMARK 465     SER P    62                                                      
REMARK 465     SER P    63                                                      
REMARK 465     ASN P    64                                                      
REMARK 465     ASN P    65                                                      
REMARK 465     ALA P    66                                                      
REMARK 465     HIS P    67                                                      
REMARK 465     SER P    68                                                      
REMARK 465     GLY P    69                                                      
REMARK 465     PHE P    70                                                      
REMARK 465     LYS P    71                                                      
REMARK 465     VAL P    72                                                      
REMARK 465     MET b     1                                                      
REMARK 465     ALA b     2                                                      
REMARK 465     GLU b     3                                                      
REMARK 465     LYS b     4                                                      
REMARK 465     GLU b     5                                                      
REMARK 465     GLU b     6                                                      
REMARK 465     ALA b     7                                                      
REMARK 465     ILE b     8                                                      
REMARK 465     PHE b     9                                                      
REMARK 465     ARG b    10                                                      
REMARK 465     SER b    11                                                      
REMARK 465     ALA b    12                                                      
REMARK 465     GLU b    13                                                      
REMARK 465     PHE b   152                                                      
REMARK 465     LEU b   153                                                      
REMARK 465     LYS b   154                                                      
REMARK 465     GLY b   155                                                      
REMARK 465     ASP b   156                                                      
REMARK 465     ASN b   157                                                      
REMARK 465     THR b   158                                                      
REMARK 465     ASP b   159                                                      
REMARK 465     SER b   160                                                      
REMARK 465     THR b   161                                                      
REMARK 465     SER b   162                                                      
REMARK 465     TYR b   163                                                      
REMARK 465     MET b   164                                                      
REMARK 465     ASP b   165                                                      
REMARK 465     GLU b   166                                                      
REMARK 465     ASP b   167                                                      
REMARK 465     MET b   168                                                      
REMARK 465     ILE b   169                                                      
REMARK 465     ASP b   170                                                      
REMARK 465     ALA b   171                                                      
REMARK 465     ASN b   172                                                      
REMARK 465     GLY b   173                                                      
REMARK 465     GLU b   174                                                      
REMARK 465     ASN b   175                                                      
REMARK 465     PRO b   221                                                      
REMARK 465     VAL b   222                                                      
REMARK 465     TYR b   223                                                      
REMARK 465     ASP b   224                                                      
REMARK 465     VAL b   225                                                      
REMARK 465     LYS b   226                                                      
REMARK 465     THR b   227                                                      
REMARK 465     ARG b   228                                                      
REMARK 465     GLU b   229                                                      
REMARK 465     TYR b   230                                                      
REMARK 465     LYS b   231                                                      
REMARK 465     HIS b   232                                                      
REMARK 465     LYS b   233                                                      
REMARK 465     ASP b   363                                                      
REMARK 465     VAL b   364                                                      
REMARK 465     PRO b   365                                                      
REMARK 465     SER b   366                                                      
REMARK 465     ILE b   367                                                      
REMARK 465     ILE b   368                                                      
REMARK 465     GLN b   369                                                      
REMARK 465     VAL b   370                                                      
REMARK 465     LEU b   371                                                      
REMARK 465     ASP b   372                                                      
REMARK 465     THR b   373                                                      
REMARK 465     ASN b   374                                                      
REMARK 465     HIS b   375                                                      
REMARK 465     THR b   376                                                      
REMARK 465     PRO b   377                                                      
REMARK 465     PRO b   378                                                      
REMARK 465     THR b   379                                                      
REMARK 465     PHE b   380                                                      
REMARK 465     HIS b   381                                                      
REMARK 465     ARG b   382                                                      
REMARK 465     THR b   383                                                      
REMARK 465     ASN b   384                                                      
REMARK 465     LYS b   385                                                      
REMARK 465     PHE b   386                                                      
REMARK 465     THR b   387                                                      
REMARK 465     ALA b   388                                                      
REMARK 465     GLY b   389                                                      
REMARK 465     PHE b   390                                                      
REMARK 465     GLN b   391                                                      
REMARK 465     SER b   392                                                      
REMARK 465     ILE b   393                                                      
REMARK 465     CYS b   394                                                      
REMARK 465     ASP b   395                                                      
REMARK 465     CYS b   396                                                      
REMARK 465     TYR b   397                                                      
REMARK 465     GLY b   398                                                      
REMARK 465     ILE b   399                                                      
REMARK 465     ALA b   400                                                      
REMARK 465     GLN b   401                                                      
REMARK 465     TYR b   402                                                      
REMARK 465     ARG b   403                                                      
REMARK 465     GLU b   404                                                      
REMARK 465     ILE b   405                                                      
REMARK 465     ASN b   406                                                      
REMARK 465     ALA b   407                                                      
REMARK 465     GLY b   408                                                      
REMARK 465     LEU b   409                                                      
REMARK 465     PRO b   410                                                      
REMARK 465     THR b   411                                                      
REMARK 465     ILE b   412                                                      
REMARK 465     VAL b   413                                                      
REMARK 465     THR b   414                                                      
REMARK 465     PHE b   415                                                      
REMARK 465     PRO b   416                                                      
REMARK 465     PHE b   417                                                      
REMARK 465     MET b   418                                                      
REMARK 465     PHE b   419                                                      
REMARK 465     ALA b   420                                                      
REMARK 465     ILE b   421                                                      
REMARK 465     MET b   422                                                      
REMARK 465     PHE b   423                                                      
REMARK 465     GLY b   424                                                      
REMARK 465     ASP b   425                                                      
REMARK 465     MET b   426                                                      
REMARK 465     GLY b   427                                                      
REMARK 465     HIS b   428                                                      
REMARK 465     GLY b   429                                                      
REMARK 465     PHE b   430                                                      
REMARK 465     LEU b   431                                                      
REMARK 465     MET b   432                                                      
REMARK 465     THR b   433                                                      
REMARK 465     LEU b   434                                                      
REMARK 465     ALA b   435                                                      
REMARK 465     ALA b   436                                                      
REMARK 465     LEU b   437                                                      
REMARK 465     SER b   438                                                      
REMARK 465     LEU b   439                                                      
REMARK 465     VAL b   440                                                      
REMARK 465     LEU b   441                                                      
REMARK 465     ASN b   442                                                      
REMARK 465     GLU b   443                                                      
REMARK 465     LYS b   444                                                      
REMARK 465     LYS b   445                                                      
REMARK 465     ILE b   446                                                      
REMARK 465     ASN b   447                                                      
REMARK 465     LYS b   448                                                      
REMARK 465     MET b   449                                                      
REMARK 465     LYS b   450                                                      
REMARK 465     ARG b   451                                                      
REMARK 465     GLY b   452                                                      
REMARK 465     GLU b   453                                                      
REMARK 465     ILE b   454                                                      
REMARK 465     PHE b   455                                                      
REMARK 465     ASP b   456                                                      
REMARK 465     MET b   457                                                      
REMARK 465     ALA b   458                                                      
REMARK 465     PHE b   459                                                      
REMARK 465     THR b   460                                                      
REMARK 465     GLY b   461                                                      
REMARK 465     ARG b   462                                                      
REMARK 465     TYR b   463                                                      
REMARK 465     ILE b   464                                                      
REMARK 465     ILE b   465                                                      
REMARK 465     LEU b   466                                                      
REMARK 465     LEU b   467                                                      
REMARK 465     MET b   468                                                      
REMARK 465     GLY b   469                                                      
REMARK 465     VAL b   470                                                      
REMARK 465     PHE b   471                                                      
REMARK 465     SER b   472                                                      
REMARK 465     MET b   473                                                      
REMARK 465     TYR b   474                                                      
REMARK 465     THR b   475                                                      
REMARK 465     GLY b   476                                                      
REMARK 465     PHE b   477                                                      
REMARK 465     LEU b   478                                                      
REMARK 465     TYR b   479                                                      
REMARK 465     ASN b   480                                                      
REMARK 465     ASP b   481                                                      
REMARK 465     ILE b   482                                                      
REMARK 465     PHE b   483                                                      
REMARK 465     SER b   484                                                      
REMARK 465     LYS b   485                                                      
REMARK 465     THR b   486                                                      
REMARK 465     MET b   487                                                      
REMARK 465     THR b   488                                                      
REMARK 465     ILE b   489                                                      
REMARK 465     PHE b   490                                                      
REMARK 465     LYS b   491                                                      
REMARK 465     SER b   492                                                      
REMARK 465     GLY b   493                                                      
REMARK 465     TRP b   494                                                      
REMARK 465     LYS b   495                                                      
REMARK 465     TRP b   496                                                      
REMARK 465     PRO b   497                                                      
REMARK 465     ASP b   498                                                      
REMARK 465     HIS b   499                                                      
REMARK 465     TRP b   500                                                      
REMARK 465     LYS b   501                                                      
REMARK 465     LYS b   502                                                      
REMARK 465     GLY b   503                                                      
REMARK 465     GLU b   504                                                      
REMARK 465     SER b   505                                                      
REMARK 465     ILE b   506                                                      
REMARK 465     THR b   507                                                      
REMARK 465     ALA b   508                                                      
REMARK 465     THR b   509                                                      
REMARK 465     SER b   510                                                      
REMARK 465     VAL b   511                                                      
REMARK 465     GLY b   512                                                      
REMARK 465     THR b   513                                                      
REMARK 465     TYR b   514                                                      
REMARK 465     PRO b   515                                                      
REMARK 465     ILE b   516                                                      
REMARK 465     GLY b   517                                                      
REMARK 465     LEU b   518                                                      
REMARK 465     ASP b   519                                                      
REMARK 465     TRP b   520                                                      
REMARK 465     ALA b   521                                                      
REMARK 465     TRP b   522                                                      
REMARK 465     HIS b   523                                                      
REMARK 465     GLY b   524                                                      
REMARK 465     THR b   525                                                      
REMARK 465     GLU b   526                                                      
REMARK 465     ASN b   527                                                      
REMARK 465     ALA b   528                                                      
REMARK 465     LEU b   529                                                      
REMARK 465     LEU b   530                                                      
REMARK 465     PHE b   531                                                      
REMARK 465     SER b   532                                                      
REMARK 465     ASN b   533                                                      
REMARK 465     SER b   534                                                      
REMARK 465     TYR b   535                                                      
REMARK 465     LYS b   536                                                      
REMARK 465     MET b   537                                                      
REMARK 465     LYS b   538                                                      
REMARK 465     LEU b   539                                                      
REMARK 465     SER b   540                                                      
REMARK 465     ILE b   541                                                      
REMARK 465     LEU b   542                                                      
REMARK 465     MET b   543                                                      
REMARK 465     GLY b   544                                                      
REMARK 465     PHE b   545                                                      
REMARK 465     ILE b   546                                                      
REMARK 465     HIS b   547                                                      
REMARK 465     MET b   548                                                      
REMARK 465     THR b   549                                                      
REMARK 465     TYR b   550                                                      
REMARK 465     SER b   551                                                      
REMARK 465     TYR b   552                                                      
REMARK 465     PHE b   553                                                      
REMARK 465     PHE b   554                                                      
REMARK 465     SER b   555                                                      
REMARK 465     LEU b   556                                                      
REMARK 465     ALA b   557                                                      
REMARK 465     ASN b   558                                                      
REMARK 465     HIS b   559                                                      
REMARK 465     LEU b   560                                                      
REMARK 465     TYR b   561                                                      
REMARK 465     PHE b   562                                                      
REMARK 465     ASN b   563                                                      
REMARK 465     SER b   564                                                      
REMARK 465     MET b   565                                                      
REMARK 465     ILE b   566                                                      
REMARK 465     ASP b   567                                                      
REMARK 465     ILE b   568                                                      
REMARK 465     ILE b   569                                                      
REMARK 465     GLY b   570                                                      
REMARK 465     ASN b   571                                                      
REMARK 465     PHE b   572                                                      
REMARK 465     ILE b   573                                                      
REMARK 465     PRO b   574                                                      
REMARK 465     GLY b   575                                                      
REMARK 465     LEU b   576                                                      
REMARK 465     LEU b   577                                                      
REMARK 465     PHE b   578                                                      
REMARK 465     MET b   579                                                      
REMARK 465     GLN b   580                                                      
REMARK 465     GLY b   581                                                      
REMARK 465     ILE b   582                                                      
REMARK 465     PHE b   583                                                      
REMARK 465     GLY b   584                                                      
REMARK 465     TYR b   585                                                      
REMARK 465     LEU b   586                                                      
REMARK 465     SER b   587                                                      
REMARK 465     VAL b   588                                                      
REMARK 465     CYS b   589                                                      
REMARK 465     ILE b   590                                                      
REMARK 465     VAL b   591                                                      
REMARK 465     TYR b   592                                                      
REMARK 465     LYS b   593                                                      
REMARK 465     TRP b   594                                                      
REMARK 465     ALA b   595                                                      
REMARK 465     VAL b   596                                                      
REMARK 465     ASP b   597                                                      
REMARK 465     TRP b   598                                                      
REMARK 465     VAL b   599                                                      
REMARK 465     LYS b   600                                                      
REMARK 465     ASP b   601                                                      
REMARK 465     GLY b   602                                                      
REMARK 465     LYS b   603                                                      
REMARK 465     PRO b   604                                                      
REMARK 465     ALA b   605                                                      
REMARK 465     PRO b   606                                                      
REMARK 465     GLY b   607                                                      
REMARK 465     LEU b   608                                                      
REMARK 465     LEU b   609                                                      
REMARK 465     ASN b   610                                                      
REMARK 465     MET b   611                                                      
REMARK 465     LEU b   612                                                      
REMARK 465     ILE b   613                                                      
REMARK 465     ASN b   614                                                      
REMARK 465     MET b   615                                                      
REMARK 465     PHE b   616                                                      
REMARK 465     LEU b   617                                                      
REMARK 465     SER b   618                                                      
REMARK 465     PRO b   619                                                      
REMARK 465     GLY b   620                                                      
REMARK 465     THR b   621                                                      
REMARK 465     ILE b   622                                                      
REMARK 465     ASP b   623                                                      
REMARK 465     ASP b   624                                                      
REMARK 465     GLU b   625                                                      
REMARK 465     LEU b   626                                                      
REMARK 465     TYR b   627                                                      
REMARK 465     PRO b   628                                                      
REMARK 465     HIS b   629                                                      
REMARK 465     GLN b   630                                                      
REMARK 465     ALA b   631                                                      
REMARK 465     LYS b   632                                                      
REMARK 465     VAL b   633                                                      
REMARK 465     GLN b   634                                                      
REMARK 465     VAL b   635                                                      
REMARK 465     PHE b   636                                                      
REMARK 465     LEU b   637                                                      
REMARK 465     LEU b   638                                                      
REMARK 465     LEU b   639                                                      
REMARK 465     MET b   640                                                      
REMARK 465     ALA b   641                                                      
REMARK 465     LEU b   642                                                      
REMARK 465     VAL b   643                                                      
REMARK 465     CYS b   644                                                      
REMARK 465     ILE b   645                                                      
REMARK 465     PRO b   646                                                      
REMARK 465     TRP b   647                                                      
REMARK 465     LEU b   648                                                      
REMARK 465     LEU b   649                                                      
REMARK 465     LEU b   650                                                      
REMARK 465     VAL b   651                                                      
REMARK 465     LYS b   652                                                      
REMARK 465     PRO b   653                                                      
REMARK 465     LEU b   654                                                      
REMARK 465     HIS b   655                                                      
REMARK 465     PHE b   656                                                      
REMARK 465     LYS b   657                                                      
REMARK 465     PHE b   658                                                      
REMARK 465     THR b   659                                                      
REMARK 465     HIS b   660                                                      
REMARK 465     LYS b   661                                                      
REMARK 465     LYS b   662                                                      
REMARK 465     LYS b   663                                                      
REMARK 465     SER b   664                                                      
REMARK 465     HIS b   665                                                      
REMARK 465     GLU b   666                                                      
REMARK 465     PRO b   667                                                      
REMARK 465     LEU b   668                                                      
REMARK 465     PRO b   669                                                      
REMARK 465     SER b   670                                                      
REMARK 465     THR b   671                                                      
REMARK 465     GLU b   672                                                      
REMARK 465     ALA b   673                                                      
REMARK 465     ASP b   674                                                      
REMARK 465     ALA b   675                                                      
REMARK 465     SER b   676                                                      
REMARK 465     SER b   677                                                      
REMARK 465     GLU b   678                                                      
REMARK 465     ASP b   679                                                      
REMARK 465     LEU b   680                                                      
REMARK 465     GLU b   681                                                      
REMARK 465     ALA b   682                                                      
REMARK 465     GLN b   683                                                      
REMARK 465     GLN b   684                                                      
REMARK 465     LEU b   685                                                      
REMARK 465     ILE b   686                                                      
REMARK 465     SER b   687                                                      
REMARK 465     ALA b   688                                                      
REMARK 465     MET b   689                                                      
REMARK 465     ASP b   690                                                      
REMARK 465     ALA b   691                                                      
REMARK 465     ASP b   692                                                      
REMARK 465     ASP b   693                                                      
REMARK 465     ALA b   694                                                      
REMARK 465     GLU b   695                                                      
REMARK 465     GLU b   696                                                      
REMARK 465     GLU b   697                                                      
REMARK 465     GLU b   698                                                      
REMARK 465     VAL b   699                                                      
REMARK 465     GLY b   700                                                      
REMARK 465     SER b   701                                                      
REMARK 465     GLY b   702                                                      
REMARK 465     SER b   703                                                      
REMARK 465     HIS b   704                                                      
REMARK 465     GLY b   705                                                      
REMARK 465     GLU b   706                                                      
REMARK 465     ASP b   707                                                      
REMARK 465     PHE b   708                                                      
REMARK 465     GLY b   709                                                      
REMARK 465     ASP b   710                                                      
REMARK 465     ILE b   711                                                      
REMARK 465     MET b   712                                                      
REMARK 465     ILE b   713                                                      
REMARK 465     HIS b   714                                                      
REMARK 465     GLN b   715                                                      
REMARK 465     VAL b   716                                                      
REMARK 465     ILE b   717                                                      
REMARK 465     HIS b   718                                                      
REMARK 465     THR b   719                                                      
REMARK 465     ILE b   720                                                      
REMARK 465     GLU b   721                                                      
REMARK 465     PHE b   722                                                      
REMARK 465     CYS b   723                                                      
REMARK 465     LEU b   724                                                      
REMARK 465     ASN b   725                                                      
REMARK 465     CYS b   726                                                      
REMARK 465     VAL b   727                                                      
REMARK 465     SER b   728                                                      
REMARK 465     HIS b   729                                                      
REMARK 465     THR b   730                                                      
REMARK 465     ALA b   731                                                      
REMARK 465     SER b   732                                                      
REMARK 465     TYR b   733                                                      
REMARK 465     LEU b   734                                                      
REMARK 465     ARG b   735                                                      
REMARK 465     LEU b   736                                                      
REMARK 465     TRP b   737                                                      
REMARK 465     ALA b   738                                                      
REMARK 465     LEU b   739                                                      
REMARK 465     SER b   740                                                      
REMARK 465     LEU b   741                                                      
REMARK 465     ALA b   742                                                      
REMARK 465     HIS b   743                                                      
REMARK 465     ALA b   744                                                      
REMARK 465     GLN b   745                                                      
REMARK 465     LEU b   746                                                      
REMARK 465     SER b   747                                                      
REMARK 465     SER b   748                                                      
REMARK 465     VAL b   749                                                      
REMARK 465     LEU b   750                                                      
REMARK 465     TRP b   751                                                      
REMARK 465     THR b   752                                                      
REMARK 465     MET b   753                                                      
REMARK 465     THR b   754                                                      
REMARK 465     ILE b   755                                                      
REMARK 465     GLN b   756                                                      
REMARK 465     ILE b   757                                                      
REMARK 465     ALA b   758                                                      
REMARK 465     PHE b   759                                                      
REMARK 465     GLY b   760                                                      
REMARK 465     PHE b   761                                                      
REMARK 465     ARG b   762                                                      
REMARK 465     GLY b   763                                                      
REMARK 465     PHE b   764                                                      
REMARK 465     VAL b   765                                                      
REMARK 465     GLY b   766                                                      
REMARK 465     VAL b   767                                                      
REMARK 465     PHE b   768                                                      
REMARK 465     MET b   769                                                      
REMARK 465     THR b   770                                                      
REMARK 465     VAL b   771                                                      
REMARK 465     ALA b   772                                                      
REMARK 465     LEU b   773                                                      
REMARK 465     PHE b   774                                                      
REMARK 465     ALA b   775                                                      
REMARK 465     MET b   776                                                      
REMARK 465     TRP b   777                                                      
REMARK 465     PHE b   778                                                      
REMARK 465     ALA b   779                                                      
REMARK 465     LEU b   780                                                      
REMARK 465     THR b   781                                                      
REMARK 465     CYS b   782                                                      
REMARK 465     ALA b   783                                                      
REMARK 465     VAL b   784                                                      
REMARK 465     LEU b   785                                                      
REMARK 465     VAL b   786                                                      
REMARK 465     LEU b   787                                                      
REMARK 465     MET b   788                                                      
REMARK 465     GLU b   789                                                      
REMARK 465     GLY b   790                                                      
REMARK 465     THR b   791                                                      
REMARK 465     SER b   792                                                      
REMARK 465     ALA b   793                                                      
REMARK 465     MET b   794                                                      
REMARK 465     LEU b   795                                                      
REMARK 465     HIS b   796                                                      
REMARK 465     SER b   797                                                      
REMARK 465     LEU b   798                                                      
REMARK 465     ARG b   799                                                      
REMARK 465     LEU b   800                                                      
REMARK 465     HIS b   801                                                      
REMARK 465     TRP b   802                                                      
REMARK 465     VAL b   803                                                      
REMARK 465     GLU b   804                                                      
REMARK 465     SER b   805                                                      
REMARK 465     MET b   806                                                      
REMARK 465     SER b   807                                                      
REMARK 465     LYS b   808                                                      
REMARK 465     PHE b   809                                                      
REMARK 465     PHE b   810                                                      
REMARK 465     VAL b   811                                                      
REMARK 465     GLY b   812                                                      
REMARK 465     GLU b   813                                                      
REMARK 465     GLY b   814                                                      
REMARK 465     LEU b   815                                                      
REMARK 465     PRO b   816                                                      
REMARK 465     TYR b   817                                                      
REMARK 465     GLU b   818                                                      
REMARK 465     PRO b   819                                                      
REMARK 465     PHE b   820                                                      
REMARK 465     ALA b   821                                                      
REMARK 465     PHE b   822                                                      
REMARK 465     GLU b   823                                                      
REMARK 465     TYR b   824                                                      
REMARK 465     LYS b   825                                                      
REMARK 465     ASP b   826                                                      
REMARK 465     MET b   827                                                      
REMARK 465     GLU b   828                                                      
REMARK 465     VAL b   829                                                      
REMARK 465     ALA b   830                                                      
REMARK 465     VAL b   831                                                      
REMARK 465     ALA b   832                                                      
REMARK 465     SER b   833                                                      
REMARK 465     ALA b   834                                                      
REMARK 465     SER b   835                                                      
REMARK 465     SER b   836                                                      
REMARK 465     SER b   837                                                      
REMARK 465     ALA b   838                                                      
REMARK 465     SER b   839                                                      
REMARK 465     SER b   840                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ALA H   107                                                      
REMARK 465     GLU H   108                                                      
REMARK 465     VAL H   109                                                      
REMARK 465     HIS H   110                                                      
REMARK 465     ILE H   111                                                      
REMARK 465     ASN H   112                                                      
REMARK 465     ALA H   113                                                      
REMARK 465     LEU H   114                                                      
REMARK 465     MET G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     SER G     3                                                      
REMARK 465     ALA G     4                                                      
REMARK 465     ILE G     5                                                      
REMARK 465     THR G     6                                                      
REMARK 465     ALA G     7                                                      
REMARK 465     PRO G   225                                                      
REMARK 465     SER G   226                                                      
REMARK 465     LYS G   227                                                      
REMARK 465     THR G   228                                                      
REMARK 465     ARG G   229                                                      
REMARK 465     LYS G   230                                                      
REMARK 465     PHE G   231                                                      
REMARK 465     PHE G   232                                                      
REMARK 465     ASP G   233                                                      
REMARK 465     MET J     1                                                      
REMARK 465     ALA J   107                                                      
REMARK 465     GLU J   108                                                      
REMARK 465     VAL J   109                                                      
REMARK 465     HIS J   110                                                      
REMARK 465     ILE J   111                                                      
REMARK 465     ASN J   112                                                      
REMARK 465     ALA J   113                                                      
REMARK 465     LEU J   114                                                      
REMARK 465     MET I     1                                                      
REMARK 465     SER I     2                                                      
REMARK 465     SER I     3                                                      
REMARK 465     ALA I     4                                                      
REMARK 465     ILE I     5                                                      
REMARK 465     THR I     6                                                      
REMARK 465     ALA I     7                                                      
REMARK 465     PRO I   225                                                      
REMARK 465     SER I   226                                                      
REMARK 465     LYS I   227                                                      
REMARK 465     THR I   228                                                      
REMARK 465     ARG I   229                                                      
REMARK 465     LYS I   230                                                      
REMARK 465     PHE I   231                                                      
REMARK 465     PHE I   232                                                      
REMARK 465     ASP I   233                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     THR Y     2                                                      
REMARK 465     GLU Y     3                                                      
REMARK 465     LEU Y     4                                                      
REMARK 465     CYS Y     5                                                      
REMARK 465     PRO Y     6                                                      
REMARK 465     VAL Y     7                                                      
REMARK 465     TYR Y     8                                                      
REMARK 465     ALA Y     9                                                      
REMARK 465     PRO Y    10                                                      
REMARK 465     MET R     1                                                      
REMARK 465     THR R     2                                                      
REMARK 465     GLU R     3                                                      
REMARK 465     LEU R     4                                                      
REMARK 465     CYS R     5                                                      
REMARK 465     PRO R     6                                                      
REMARK 465     VAL R     7                                                      
REMARK 465     TYR R     8                                                      
REMARK 465     ALA R     9                                                      
REMARK 465     PRO R    10                                                      
REMARK 465     MET U     1                                                      
REMARK 465     THR U     2                                                      
REMARK 465     GLU U     3                                                      
REMARK 465     LEU U     4                                                      
REMARK 465     CYS U     5                                                      
REMARK 465     PRO U     6                                                      
REMARK 465     VAL U     7                                                      
REMARK 465     TYR U     8                                                      
REMARK 465     ALA U     9                                                      
REMARK 465     PRO U    10                                                      
REMARK 465     MET V     1                                                      
REMARK 465     THR V     2                                                      
REMARK 465     GLU V     3                                                      
REMARK 465     LEU V     4                                                      
REMARK 465     CYS V     5                                                      
REMARK 465     PRO V     6                                                      
REMARK 465     VAL V     7                                                      
REMARK 465     TYR V     8                                                      
REMARK 465     ALA V     9                                                      
REMARK 465     PRO V    10                                                      
REMARK 465     MET T     1                                                      
REMARK 465     THR T     2                                                      
REMARK 465     GLU T     3                                                      
REMARK 465     LEU T     4                                                      
REMARK 465     CYS T     5                                                      
REMARK 465     PRO T     6                                                      
REMARK 465     VAL T     7                                                      
REMARK 465     TYR T     8                                                      
REMARK 465     ALA T     9                                                      
REMARK 465     PRO T    10                                                      
REMARK 465     MET W     1                                                      
REMARK 465     THR W     2                                                      
REMARK 465     GLU W     3                                                      
REMARK 465     LEU W     4                                                      
REMARK 465     CYS W     5                                                      
REMARK 465     PRO W     6                                                      
REMARK 465     VAL W     7                                                      
REMARK 465     TYR W     8                                                      
REMARK 465     ALA W     9                                                      
REMARK 465     PRO W    10                                                      
REMARK 465     MET S     1                                                      
REMARK 465     THR S     2                                                      
REMARK 465     GLU S     3                                                      
REMARK 465     LEU S     4                                                      
REMARK 465     CYS S     5                                                      
REMARK 465     PRO S     6                                                      
REMARK 465     VAL S     7                                                      
REMARK 465     TYR S     8                                                      
REMARK 465     ALA S     9                                                      
REMARK 465     PRO S    10                                                      
REMARK 465     MET X     1                                                      
REMARK 465     THR X     2                                                      
REMARK 465     GLU X     3                                                      
REMARK 465     LEU X     4                                                      
REMARK 465     CYS X     5                                                      
REMARK 465     PRO X     6                                                      
REMARK 465     VAL X     7                                                      
REMARK 465     TYR X     8                                                      
REMARK 465     ALA X     9                                                      
REMARK 465     PRO X    10                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     THR Z     2                                                      
REMARK 465     GLU Z     3                                                      
REMARK 465     LEU Z     4                                                      
REMARK 465     CYS Z     5                                                      
REMARK 465     PRO Z     6                                                      
REMARK 465     VAL Z     7                                                      
REMARK 465     TYR Z     8                                                      
REMARK 465     ALA Z     9                                                      
REMARK 465     PRO Z    10                                                      
REMARK 465     MET a     1                                                      
REMARK 465     THR a     2                                                      
REMARK 465     GLU a     3                                                      
REMARK 465     LEU a     4                                                      
REMARK 465     CYS a     5                                                      
REMARK 465     PRO a     6                                                      
REMARK 465     VAL a     7                                                      
REMARK 465     TYR a     8                                                      
REMARK 465     ALA a     9                                                      
REMARK 465     PRO a    10                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    GLU b   200     CD1  TRP b   204              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    ARG M  12   CZ    ARG M  12   NH1     0.086                       
REMARK 500    ARG M  34   NE    ARG M  34   CZ      0.083                       
REMARK 500    SER M  36   CA    SER M  36   CB      0.096                       
REMARK 500    ARG M  42   CZ    ARG M  42   NH2     0.097                       
REMARK 500    ARG M  91   CZ    ARG M  91   NH2     0.081                       
REMARK 500    ARG M 121   NE    ARG M 121   CZ      0.085                       
REMARK 500    ARG M 169   CZ    ARG M 169   NH2     0.081                       
REMARK 500    ARG M 180   CZ    ARG M 180   NH2     0.094                       
REMARK 500    SER M 190   CB    SER M 190   OG      0.079                       
REMARK 500    ARG M 197   CZ    ARG M 197   NH1     0.085                       
REMARK 500    TYR M 201   CZ    TYR M 201   CE2     0.081                       
REMARK 500    ARG N  78   NE    ARG N  78   CZ      0.080                       
REMARK 500    ARG N 111   NE    ARG N 111   CZ      0.081                       
REMARK 500    TYR A 105   CE1   TYR A 105   CZ      0.078                       
REMARK 500    TYR A 105   CZ    TYR A 105   CE2     0.079                       
REMARK 500    ARG A 177   CZ    ARG A 177   NH2     0.079                       
REMARK 500    ARG A 179   CZ    ARG A 179   NH1     0.104                       
REMARK 500    PHE A 258   CB    PHE A 258   CG     -0.111                       
REMARK 500    ARG A 314   NE    ARG A 314   CZ      0.079                       
REMARK 500    PHE A 343   CG    PHE A 343   CD2     0.095                       
REMARK 500    ARG A 344   CZ    ARG A 344   NH1     0.083                       
REMARK 500    ARG A 359   CZ    ARG A 359   NH1     0.104                       
REMARK 500    TYR A 392   CG    TYR A 392   CD2     0.080                       
REMARK 500    SER A 409   CA    SER A 409   CB      0.100                       
REMARK 500    TYR A 553   CG    TYR A 553   CD2     0.090                       
REMARK 500    ARG A 591   CZ    ARG A 591   NH2     0.079                       
REMARK 500    GLY A 592   CA    GLY A 592   C      -0.110                       
REMARK 500    TYR B 131   CZ    TYR B 131   OH      0.106                       
REMARK 500    ARG B 144   CZ    ARG B 144   NH2     0.080                       
REMARK 500    ARG B 302   CZ    ARG B 302   NH1     0.079                       
REMARK 500    TYR B 304   CE1   TYR B 304   CZ      0.095                       
REMARK 500    ARG B 325   CD    ARG B 325   NE      0.103                       
REMARK 500    ARG B 325   CZ    ARG B 325   NH1     0.079                       
REMARK 500    TYR B 370   CZ    TYR B 370   CE2     0.086                       
REMARK 500    SER B 426   CA    SER B 426   CB      0.115                       
REMARK 500    ARG C 110   CD    ARG C 110   NE      0.140                       
REMARK 500    ARG C 314   CZ    ARG C 314   NH2     0.083                       
REMARK 500    TYR C 383   CB    TYR C 383   CG      0.107                       
REMARK 500    TYR C 392   CB    TYR C 392   CG      0.092                       
REMARK 500    SER C 417   CA    SER C 417   CB      0.093                       
REMARK 500    TYR C 460   CG    TYR C 460   CD1     0.079                       
REMARK 500    TYR C 471   CZ    TYR C 471   OH      0.122                       
REMARK 500    PHE C 478   CG    PHE C 478   CD2     0.092                       
REMARK 500    ARG D  74   CD    ARG D  74   NE      0.117                       
REMARK 500    HIS D 201   CB    HIS D 201   CG     -0.116                       
REMARK 500    GLU D 205   CD    GLU D 205   OE2     0.067                       
REMARK 500    PHE D 212   CG    PHE D 212   CD2     0.106                       
REMARK 500    GLU D 264   CD    GLU D 264   OE2     0.073                       
REMARK 500    ARG D 272   NE    ARG D 272   CZ      0.084                       
REMARK 500    ARG D 289   CZ    ARG D 289   NH2     0.085                       
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     147 BOND DEVIATIONS.                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PHE M   9   CB  -  CG  -  CD2 ANGL. DEV. =  -7.0 DEGREES          
REMARK 500    ARG M  12   CD  -  NE  -  CZ  ANGL. DEV. =   8.6 DEGREES          
REMARK 500    ARG M  12   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.8 DEGREES          
REMARK 500    ARG M  42   NE  -  CZ  -  NH2 ANGL. DEV. =   3.0 DEGREES          
REMARK 500    ARG M  44   CB  -  CA  -  C   ANGL. DEV. = -12.2 DEGREES          
REMARK 500    TYR M  73   CD1 -  CE1 -  CZ  ANGL. DEV. =  -5.8 DEGREES          
REMARK 500    TYR M  81   CB  -  CG  -  CD1 ANGL. DEV. =  -3.8 DEGREES          
REMARK 500    ARG M  91   NE  -  CZ  -  NH1 ANGL. DEV. =   8.7 DEGREES          
REMARK 500    ARG M  91   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.8 DEGREES          
REMARK 500    PHE M  92   CB  -  CG  -  CD1 ANGL. DEV. =   9.8 DEGREES          
REMARK 500    ARG M  97   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.1 DEGREES          
REMARK 500    ARG M  97   NE  -  CZ  -  NH2 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    TYR M 105   CB  -  CG  -  CD2 ANGL. DEV. =   3.7 DEGREES          
REMARK 500    PHE M 120   CB  -  CG  -  CD2 ANGL. DEV. =  -6.4 DEGREES          
REMARK 500    ARG M 134   NE  -  CZ  -  NH1 ANGL. DEV. =   4.2 DEGREES          
REMARK 500    TYR M 139   CB  -  CG  -  CD2 ANGL. DEV. =   4.6 DEGREES          
REMARK 500    ARG M 141   NE  -  CZ  -  NH1 ANGL. DEV. =   4.1 DEGREES          
REMARK 500    VAL M 143   CA  -  CB  -  CG1 ANGL. DEV. =   9.6 DEGREES          
REMARK 500    ARG M 168   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.3 DEGREES          
REMARK 500    ARG M 169   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500    ARG M 169   NE  -  CZ  -  NH2 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    ALA M 172   CB  -  CA  -  C   ANGL. DEV. =  -9.6 DEGREES          
REMARK 500    ARG M 197   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.2 DEGREES          
REMARK 500    ARG M 202   NE  -  CZ  -  NH2 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    PHE N  37   CB  -  CG  -  CD2 ANGL. DEV. =   4.6 DEGREES          
REMARK 500    PHE N  37   CB  -  CG  -  CD1 ANGL. DEV. =  -4.8 DEGREES          
REMARK 500    TYR N  40   CB  -  CG  -  CD2 ANGL. DEV. =  -4.4 DEGREES          
REMARK 500    TYR N  40   CB  -  CG  -  CD1 ANGL. DEV. =   4.3 DEGREES          
REMARK 500    GLU N  42   OE1 -  CD  -  OE2 ANGL. DEV. =  -7.6 DEGREES          
REMARK 500    ARG N  61   NH1 -  CZ  -  NH2 ANGL. DEV. =  -8.7 DEGREES          
REMARK 500    ARG N  61   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES          
REMARK 500    ARG N  61   NE  -  CZ  -  NH2 ANGL. DEV. =   4.8 DEGREES          
REMARK 500    ASP N  82   N   -  CA  -  CB  ANGL. DEV. =  12.7 DEGREES          
REMARK 500    TYR N 101   CB  -  CG  -  CD2 ANGL. DEV. =  -4.2 DEGREES          
REMARK 500    ARG N 113   NH1 -  CZ  -  NH2 ANGL. DEV. =  -7.9 DEGREES          
REMARK 500    ARG N 113   NE  -  CZ  -  NH1 ANGL. DEV. =   6.5 DEGREES          
REMARK 500    TYR A  24   CB  -  CG  -  CD2 ANGL. DEV. =  -4.4 DEGREES          
REMARK 500    TYR A  24   CG  -  CD1 -  CE1 ANGL. DEV. =  -4.8 DEGREES          
REMARK 500    TYR A  24   CG  -  CD2 -  CE2 ANGL. DEV. =  -4.9 DEGREES          
REMARK 500    TYR A  46   CB  -  CG  -  CD2 ANGL. DEV. =  -6.7 DEGREES          
REMARK 500    TYR A  46   CB  -  CG  -  CD1 ANGL. DEV. =   8.4 DEGREES          
REMARK 500    ASP A  64   CB  -  CG  -  OD1 ANGL. DEV. =  -5.8 DEGREES          
REMARK 500    ASP A  66   CB  -  CG  -  OD1 ANGL. DEV. =   6.8 DEGREES          
REMARK 500    ASP A  83   CB  -  CG  -  OD1 ANGL. DEV. =  -7.5 DEGREES          
REMARK 500    ARG A  87   NE  -  CZ  -  NH1 ANGL. DEV. =   5.3 DEGREES          
REMARK 500    ARG A  87   NE  -  CZ  -  NH2 ANGL. DEV. =  -5.2 DEGREES          
REMARK 500    TYR A 123   CB  -  CG  -  CD2 ANGL. DEV. =  -5.5 DEGREES          
REMARK 500    TYR A 123   CB  -  CG  -  CD1 ANGL. DEV. =   5.0 DEGREES          
REMARK 500    ARG A 126   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.7 DEGREES          
REMARK 500    ASP A 129   CB  -  CG  -  OD1 ANGL. DEV. =   6.3 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     751 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER M  88        4.19   -159.57                                   
REMARK 500    SER M 102     -152.07     51.50                                   
REMARK 500    LYS N   4       14.08   -174.09                                   
REMARK 500    THR N   6        7.68   -151.74                                   
REMARK 500    ILE N  25      -40.19   -140.39                                   
REMARK 500    GLU N  31       -4.27   -159.25                                   
REMARK 500    ASP N  98       37.46     73.45                                   
REMARK 500    ASN A  39       30.18     75.18                                   
REMARK 500    MET A  45       50.24    -90.54                                   
REMARK 500    TYR A  46       -7.69   -160.36                                   
REMARK 500    GLU A  75      124.49    -24.66                                   
REMARK 500    PRO A  91      173.75    -58.45                                   
REMARK 500    GLN A 109      102.30     80.59                                   
REMARK 500    LYS A 145       13.89   -140.39                                   
REMARK 500    GLU A 163      -24.49   -147.68                                   
REMARK 500    ARG A 177       20.05     89.60                                   
REMARK 500    PRO A 187     -164.16    -77.55                                   
REMARK 500    PHE A 202       81.00   -159.86                                   
REMARK 500    ASP A 203       64.72     78.96                                   
REMARK 500    SER A 207     -179.50    165.34                                   
REMARK 500    ASP A 230       -3.60   -159.56                                   
REMARK 500    PHE A 244       90.00   -153.19                                   
REMARK 500    PRO A 245      122.17    -22.82                                   
REMARK 500    ALA A 257        9.30   -179.36                                   
REMARK 500    MET A 304       15.33   -149.65                                   
REMARK 500    SER A 305      138.15     70.83                                   
REMARK 500    LYS A 308       49.58     81.93                                   
REMARK 500    GLU A 309       76.70     55.25                                   
REMARK 500    PRO A 310      -70.00    -44.87                                   
REMARK 500    PRO A 375     -157.20    -87.65                                   
REMARK 500    ALA A 376     -120.25   -142.97                                   
REMARK 500    PRO A 381      158.32    -41.09                                   
REMARK 500    ASP A 405      114.82     63.69                                   
REMARK 500    LYS A 449       51.56     79.69                                   
REMARK 500    PRO A 452     -165.89    -65.23                                   
REMARK 500    TYR A 475      -48.87    176.58                                   
REMARK 500    ALA A 506       16.19   -154.93                                   
REMARK 500    PHE A 525      -60.01    -93.64                                   
REMARK 500    ASN A 529        2.53   -171.75                                   
REMARK 500    GLU A 593      -98.85   -147.01                                   
REMARK 500    LYS A 594       -7.49   -143.03                                   
REMARK 500    GLU A 595      -12.28   -167.67                                   
REMARK 500    VAL B  44      172.94    -49.11                                   
REMARK 500    ASP B  73       41.98     75.71                                   
REMARK 500    THR B  83       -0.52   -174.11                                   
REMARK 500    LYS B  89      -15.02   -150.59                                   
REMARK 500    ASP B 114     -155.78    -97.00                                   
REMARK 500    PRO B 119      142.05    -36.82                                   
REMARK 500    ASN B 122       25.17     80.43                                   
REMARK 500    LYS B 125      155.24    -43.27                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     360 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 VAL F   44     LYS F   45                 -149.64                    
REMARK 500 GLY b   86     ASP b   87                  144.21                    
REMARK 500 GLU b  268     GLY b  269                 -144.11                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    ARG M  34         0.09    SIDE CHAIN                              
REMARK 500    TYR M  81         0.07    SIDE CHAIN                              
REMARK 500    TYR M 112         0.07    SIDE CHAIN                              
REMARK 500    ARG M 134         0.08    SIDE CHAIN                              
REMARK 500    TYR M 139         0.08    SIDE CHAIN                              
REMARK 500    TYR M 187         0.08    SIDE CHAIN                              
REMARK 500    PHE M 200         0.12    SIDE CHAIN                              
REMARK 500    ARG N   5         0.09    SIDE CHAIN                              
REMARK 500    PHE N  57         0.08    SIDE CHAIN                              
REMARK 500    TYR A  46         0.10    SIDE CHAIN                              
REMARK 500    ARG A 110         0.11    SIDE CHAIN                              
REMARK 500    ARG A 135         0.08    SIDE CHAIN                              
REMARK 500    PHE A 244         0.06    SIDE CHAIN                              
REMARK 500    TYR A 301         0.14    SIDE CHAIN                              
REMARK 500    TYR A 383         0.17    SIDE CHAIN                              
REMARK 500    ARG A 448         0.09    SIDE CHAIN                              
REMARK 500    TYR A 463         0.09    SIDE CHAIN                              
REMARK 500    PHE A 586         0.08    SIDE CHAIN                              
REMARK 500    PHE A 611         0.09    SIDE CHAIN                              
REMARK 500    TYR B 142         0.07    SIDE CHAIN                              
REMARK 500    ARG B 144         0.09    SIDE CHAIN                              
REMARK 500    ARG B 195         0.13    SIDE CHAIN                              
REMARK 500    ARG B 223         0.09    SIDE CHAIN                              
REMARK 500    PHE B 225         0.07    SIDE CHAIN                              
REMARK 500    TYR B 265         0.10    SIDE CHAIN                              
REMARK 500    ARG B 272         0.15    SIDE CHAIN                              
REMARK 500    ARG B 302         0.13    SIDE CHAIN                              
REMARK 500    ARG B 325         0.10    SIDE CHAIN                              
REMARK 500    ARG B 381         0.07    SIDE CHAIN                              
REMARK 500    ARG B 393         0.10    SIDE CHAIN                              
REMARK 500    PHE B 455         0.09    SIDE CHAIN                              
REMARK 500    ARG B 475         0.11    SIDE CHAIN                              
REMARK 500    TYR C 123         0.12    SIDE CHAIN                              
REMARK 500    TYR C 191         0.10    SIDE CHAIN                              
REMARK 500    ARG C 218         0.09    SIDE CHAIN                              
REMARK 500    TYR C 301         0.07    SIDE CHAIN                              
REMARK 500    TYR C 342         0.08    SIDE CHAIN                              
REMARK 500    TYR C 383         0.07    SIDE CHAIN                              
REMARK 500    ARG C 394         0.10    SIDE CHAIN                              
REMARK 500    PHE C 438         0.09    SIDE CHAIN                              
REMARK 500    TYR C 460         0.10    SIDE CHAIN                              
REMARK 500    PHE C 478         0.06    SIDE CHAIN                              
REMARK 500    ARG C 482         0.07    SIDE CHAIN                              
REMARK 500    ARG C 548         0.13    SIDE CHAIN                              
REMARK 500    TYR C 553         0.11    SIDE CHAIN                              
REMARK 500    ARG C 610         0.08    SIDE CHAIN                              
REMARK 500    ARG D  48         0.12    SIDE CHAIN                              
REMARK 500    ARG D  74         0.10    SIDE CHAIN                              
REMARK 500    TYR D 131         0.10    SIDE CHAIN                              
REMARK 500    TYR D 142         0.11    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     160 PLANE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    SER A 153        -10.02                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR                        
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE                                    
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500    ILE M 163        25.0      L          L   OUTSIDE RANGE           
REMARK 500    ILE M 185        23.1      L          L   OUTSIDE RANGE           
REMARK 500    ARG M 197        20.8      L          L   OUTSIDE RANGE           
REMARK 500    ASN N  70        25.0      L          L   OUTSIDE RANGE           
REMARK 500    LEU N 115        24.7      L          L   OUTSIDE RANGE           
REMARK 500    PHE A 258        24.4      L          L   OUTSIDE RANGE           
REMARK 500    LEU A 467        24.8      L          L   OUTSIDE RANGE           
REMARK 500    TRP A 541        23.6      L          L   OUTSIDE RANGE           
REMARK 500    ASN B 140        23.4      L          L   OUTSIDE RANGE           
REMARK 500    ARG B 195        22.3      L          L   OUTSIDE RANGE           
REMARK 500    ARG B 325        20.6      L          L   OUTSIDE RANGE           
REMARK 500    GLU C  47        24.6      L          L   OUTSIDE RANGE           
REMARK 500    ASN C  55        24.9      L          L   OUTSIDE RANGE           
REMARK 500    SER C 332        24.4      L          L   OUTSIDE RANGE           
REMARK 500    ALA C 446        23.6      L          L   OUTSIDE RANGE           
REMARK 500    TYR C 475        23.0      L          L   OUTSIDE RANGE           
REMARK 500    PHE C 525        25.0      L          L   OUTSIDE RANGE           
REMARK 500    THR D 249        23.9      L          L   OUTSIDE RANGE           
REMARK 500    ILE D 250        24.1      L          L   OUTSIDE RANGE           
REMARK 500    ILE D 253        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ASP D 340        24.9      L          L   OUTSIDE RANGE           
REMARK 500    PHE E 258        21.4      L          L   OUTSIDE RANGE           
REMARK 500    MET E 304        24.4      L          L   OUTSIDE RANGE           
REMARK 500    GLU E 309        23.7      L          L   OUTSIDE RANGE           
REMARK 500    THR E 429        23.8      L          L   OUTSIDE RANGE           
REMARK 500    LYS E 449        21.7      L          L   OUTSIDE RANGE           
REMARK 500    THR E 519        23.4      L          L   OUTSIDE RANGE           
REMARK 500    GLN E 558        23.9      L          L   OUTSIDE RANGE           
REMARK 500    ASN F  50        24.5      L          L   OUTSIDE RANGE           
REMARK 500    ASN F 140        21.9      L          L   OUTSIDE RANGE           
REMARK 500    ARG F 166        24.2      L          L   OUTSIDE RANGE           
REMARK 500    ARG F 195        18.7      L          L   OUTSIDE RANGE           
REMARK 500    GLU F 323        24.4      L          L   OUTSIDE RANGE           
REMARK 500    VAL F 420        24.7      L          L   OUTSIDE RANGE           
REMARK 500    LEU Q 124        24.0      L          L   OUTSIDE RANGE           
REMARK 500    ASP Q 191        25.0      L          L   OUTSIDE RANGE           
REMARK 500    ILE Q 200        22.9      L          L   OUTSIDE RANGE           
REMARK 500    VAL Q 265        24.9      L          L   OUTSIDE RANGE           
REMARK 500    VAL K  13        23.2      L          L   OUTSIDE RANGE           
REMARK 500    LEU K 133        23.2      L          L   OUTSIDE RANGE           
REMARK 500    ILE P 171        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ASP P 273        24.4      L          L   OUTSIDE RANGE           
REMARK 500    ILE P 339        22.3      L          L   OUTSIDE RANGE           
REMARK 500    ILE P 427        24.2      L          L   OUTSIDE RANGE           
REMARK 500    HIS P 456        24.5      L          L   OUTSIDE RANGE           
REMARK 500    ALA b 347        23.4      L          L   OUTSIDE RANGE           
REMARK 500    TYR O  97        20.4      L          L   OUTSIDE RANGE           
REMARK 500    TYR O 210        23.1      L          L   OUTSIDE RANGE           
REMARK 500    ALA O 220        24.5      L          L   OUTSIDE RANGE           
REMARK 500    THR O 247        24.0      L          L   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      86 CHIRALITY DEVIATIONS.                         
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-6284   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6285   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6286   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 3J9U   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3J9V   RELATED DB: PDB                                   
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 CHAINS A, C, AND E CONTAIN RESIDUES 2-283 and 738-1071 OF UNP        
REMARK 999 P17255 WITH RESIDUES 284-737 REMOVED.                                
DBREF  3J9T M    1   256  UNP    P32610   VATD_YEAST       1    256             
DBREF  3J9T N    1   118  UNP    P39111   VATF_YEAST       1    118             
DBREF  3J9T A    1   282  UNP    P17255   VATA_YEAST       2    283             
DBREF  3J9T A  283   616  UNP    P17255   VATA_YEAST     738   1071             
DBREF  3J9T B    1   517  UNP    P16140   VATB_YEAST       1    517             
DBREF  3J9T C    1   282  UNP    P17255   VATA_YEAST       2    283             
DBREF  3J9T C  283   616  UNP    P17255   VATA_YEAST     738   1071             
DBREF  3J9T D    1   517  UNP    P16140   VATB_YEAST       1    517             
DBREF  3J9T E    1   282  UNP    P17255   VATA_YEAST       2    283             
DBREF  3J9T E  283   616  UNP    P17255   VATA_YEAST     738   1071             
DBREF  3J9T F    1   517  UNP    P16140   VATB_YEAST       1    517             
DBREF  3J9T Q    1   345  UNP    P32366   VA0D_YEAST       1    345             
DBREF  3J9T L    1   114  UNP    P48836   VATG_YEAST       1    114             
DBREF  3J9T K    1   233  UNP    P22203   VATE_YEAST       1    233             
DBREF  3J9T P    1   478  UNP    P41807   VATH_YEAST       1    478             
DBREF  3J9T b    1   840  UNP    P32563   VPH1_YEAST       1    840             
DBREF  3J9T O    1   392  UNP    P31412   VATC_YEAST       1    392             
DBREF  3J9T H    1   114  UNP    P48836   VATG_YEAST       1    114             
DBREF  3J9T G    1   233  UNP    P22203   VATE_YEAST       1    233             
DBREF  3J9T J    1   114  UNP    P48836   VATG_YEAST       1    114             
DBREF  3J9T I    1   233  UNP    P22203   VATE_YEAST       1    233             
DBREF  3J9T Y    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T R    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T U    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T V    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T T    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T W    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T S    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T X    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T Z    1   160  UNP    P25515   VATL1_YEAST      1    160             
DBREF  3J9T a    1   160  UNP    P25515   VATL1_YEAST      1    160             
SEQRES   1 M  256  MET SER GLY ASN ARG GLU GLN VAL PHE PRO THR ARG MET          
SEQRES   2 M  256  THR LEU GLY LEU MET LYS THR LYS LEU LYS GLY ALA ASN          
SEQRES   3 M  256  GLN GLY TYR SER LEU LEU LYS ARG LYS SER GLU ALA LEU          
SEQRES   4 M  256  THR LYS ARG PHE ARG ASP ILE THR LYS ARG ILE ASP ASP          
SEQRES   5 M  256  ALA LYS GLN LYS MET GLY ARG VAL MET GLN THR ALA ALA          
SEQRES   6 M  256  PHE SER LEU ALA GLU VAL SER TYR ALA THR GLY GLU ASN          
SEQRES   7 M  256  ILE GLY TYR GLN VAL GLN GLU SER VAL SER THR ALA ARG          
SEQRES   8 M  256  PHE LYS VAL ARG ALA ARG GLN GLU ASN VAL SER GLY VAL          
SEQRES   9 M  256  TYR LEU SER GLN PHE GLU SER TYR ILE ASP PRO GLU ILE          
SEQRES  10 M  256  ASN ASP PHE ARG LEU THR GLY LEU GLY ARG GLY GLY GLN          
SEQRES  11 M  256  GLN VAL GLN ARG ALA LYS GLU ILE TYR SER ARG ALA VAL          
SEQRES  12 M  256  GLU THR LEU VAL GLU LEU ALA SER LEU GLN THR ALA PHE          
SEQRES  13 M  256  ILE ILE LEU ASP GLU VAL ILE LYS VAL THR ASN ARG ARG          
SEQRES  14 M  256  VAL ASN ALA ILE GLU HIS VAL ILE ILE PRO ARG THR GLU          
SEQRES  15 M  256  ASN THR ILE ALA TYR ILE ASN SER GLU LEU ASP GLU LEU          
SEQRES  16 M  256  ASP ARG GLU GLU PHE TYR ARG LEU LYS LYS VAL GLN GLU          
SEQRES  17 M  256  LYS LYS GLN ASN GLU THR ALA LYS LEU ASP ALA GLU MET          
SEQRES  18 M  256  LYS LEU LYS ARG ASP ARG ALA GLU GLN ASP ALA SER GLU          
SEQRES  19 M  256  VAL ALA ALA ASP GLU GLU PRO GLN GLY GLU THR LEU VAL          
SEQRES  20 M  256  ALA ASP GLN GLU ASP ASP VAL ILE PHE                          
SEQRES   1 N  118  MET ALA GLU LYS ARG THR LEU ILE ALA VAL ILE ALA ASP          
SEQRES   2 N  118  GLU ASP THR THR THR GLY LEU LEU LEU ALA GLY ILE GLY          
SEQRES   3 N  118  GLN ILE THR PRO GLU THR GLN GLU LYS ASN PHE PHE VAL          
SEQRES   4 N  118  TYR GLN GLU GLY LYS THR THR LYS GLU GLU ILE THR ASP          
SEQRES   5 N  118  LYS PHE ASN HIS PHE THR GLU GLU ARG ASP ASP ILE ALA          
SEQRES   6 N  118  ILE LEU LEU ILE ASN GLN HIS ILE ALA GLU ASN ILE ARG          
SEQRES   7 N  118  ALA ARG VAL ASP SER PHE THR ASN ALA PHE PRO ALA ILE          
SEQRES   8 N  118  LEU GLU ILE PRO SER LYS ASP HIS PRO TYR ASP PRO GLU          
SEQRES   9 N  118  LYS ASP SER VAL LEU LYS ARG VAL ARG LYS LEU PHE GLY          
SEQRES  10 N  118  GLU                                                          
SEQRES   1 A  616  ALA GLY ALA ILE GLU ASN ALA ARG LYS GLU ILE LYS ARG          
SEQRES   2 A  616  ILE SER LEU GLU ASP HIS ALA GLU SER GLU TYR GLY ALA          
SEQRES   3 A  616  ILE TYR SER VAL SER GLY PRO VAL VAL ILE ALA GLU ASN          
SEQRES   4 A  616  MET ILE GLY CYS ALA MET TYR GLU LEU VAL LYS VAL GLY          
SEQRES   5 A  616  HIS ASP ASN LEU VAL GLY GLU VAL ILE ARG ILE ASP GLY          
SEQRES   6 A  616  ASP LYS ALA THR ILE GLN VAL TYR GLU GLU THR ALA GLY          
SEQRES   7 A  616  LEU THR VAL GLY ASP PRO VAL LEU ARG THR GLY LYS PRO          
SEQRES   8 A  616  LEU SER VAL GLU LEU GLY PRO GLY LEU MET GLU THR ILE          
SEQRES   9 A  616  TYR ASP GLY ILE GLN ARG PRO LEU LYS ALA ILE LYS GLU          
SEQRES  10 A  616  GLU SER GLN SER ILE TYR ILE PRO ARG GLY ILE ASP THR          
SEQRES  11 A  616  PRO ALA LEU ASP ARG THR ILE LYS TRP GLN PHE THR PRO          
SEQRES  12 A  616  GLY LYS PHE GLN VAL GLY ASP HIS ILE SER GLY GLY ASP          
SEQRES  13 A  616  ILE TYR GLY SER VAL PHE GLU ASN SER LEU ILE SER SER          
SEQRES  14 A  616  HIS LYS ILE LEU LEU PRO PRO ARG SER ARG GLY THR ILE          
SEQRES  15 A  616  THR TRP ILE ALA PRO ALA GLY GLU TYR THR LEU ASP GLU          
SEQRES  16 A  616  LYS ILE LEU GLU VAL GLU PHE ASP GLY LYS LYS SER ASP          
SEQRES  17 A  616  PHE THR LEU TYR HIS THR TRP PRO VAL ARG VAL PRO ARG          
SEQRES  18 A  616  PRO VAL THR GLU LYS LEU SER ALA ASP TYR PRO LEU LEU          
SEQRES  19 A  616  THR GLY GLN ARG VAL LEU ASP ALA LEU PHE PRO CYS VAL          
SEQRES  20 A  616  GLN GLY GLY THR THR CYS ILE PRO GLY ALA PHE GLY CYS          
SEQRES  21 A  616  GLY LYS THR VAL ILE SER GLN SER LEU SER LYS TYR SER          
SEQRES  22 A  616  ASN SER ASP ALA ILE ILE TYR VAL GLY CYS GLY GLU ARG          
SEQRES  23 A  616  GLY ASN GLU MET ALA GLU VAL LEU MET GLU PHE PRO GLU          
SEQRES  24 A  616  LEU TYR THR GLU MET SER GLY THR LYS GLU PRO ILE MET          
SEQRES  25 A  616  LYS ARG THR THR LEU VAL ALA ASN THR SER ASN MET PRO          
SEQRES  26 A  616  VAL ALA ALA ARG GLU ALA SER ILE TYR THR GLY ILE THR          
SEQRES  27 A  616  LEU ALA GLU TYR PHE ARG ASP GLN GLY LYS ASN VAL SER          
SEQRES  28 A  616  MET ILE ALA ASP SER SER SER ARG TRP ALA GLU ALA LEU          
SEQRES  29 A  616  ARG GLU ILE SER GLY ARG LEU GLY GLU MET PRO ALA ASP          
SEQRES  30 A  616  GLN GLY PHE PRO ALA TYR LEU GLY ALA LYS LEU ALA SER          
SEQRES  31 A  616  PHE TYR GLU ARG ALA GLY LYS ALA VAL ALA LEU GLY SER          
SEQRES  32 A  616  PRO ASP ARG THR GLY SER VAL SER ILE VAL ALA ALA VAL          
SEQRES  33 A  616  SER PRO ALA GLY GLY ASP PHE SER ASP PRO VAL THR THR          
SEQRES  34 A  616  ALA THR LEU GLY ILE THR GLN VAL PHE TRP GLY LEU ASP          
SEQRES  35 A  616  LYS LYS LEU ALA GLN ARG LYS HIS PHE PRO SER ILE ASN          
SEQRES  36 A  616  THR SER VAL SER TYR SER LYS TYR THR ASN VAL LEU ASN          
SEQRES  37 A  616  LYS PHE TYR ASP SER ASN TYR PRO GLU PHE PRO VAL LEU          
SEQRES  38 A  616  ARG ASP ARG MET LYS GLU ILE LEU SER ASN ALA GLU GLU          
SEQRES  39 A  616  LEU GLU GLN VAL VAL GLN LEU VAL GLY LYS SER ALA LEU          
SEQRES  40 A  616  SER ASP SER ASP LYS ILE THR LEU ASP VAL ALA THR LEU          
SEQRES  41 A  616  ILE LYS GLU ASP PHE LEU GLN GLN ASN GLY TYR SER THR          
SEQRES  42 A  616  TYR ASP ALA PHE CYS PRO ILE TRP LYS THR PHE ASP MET          
SEQRES  43 A  616  MET ARG ALA PHE ILE SER TYR HIS ASP GLU ALA GLN LYS          
SEQRES  44 A  616  ALA VAL ALA ASN GLY ALA ASN TRP SER LYS LEU ALA ASP          
SEQRES  45 A  616  SER THR GLY ASP VAL LYS HIS ALA VAL SER SER SER LYS          
SEQRES  46 A  616  PHE PHE GLU PRO SER ARG GLY GLU LYS GLU VAL HIS GLY          
SEQRES  47 A  616  GLU PHE GLU LYS LEU LEU SER THR MET GLN GLU ARG PHE          
SEQRES  48 A  616  ALA GLU SER THR ASP                                          
SEQRES   1 B  517  MET VAL LEU SER ASP LYS GLU LEU PHE ALA ILE ASN LYS          
SEQRES   2 B  517  LYS ALA VAL GLU GLN GLY PHE ASN VAL LYS PRO ARG LEU          
SEQRES   3 B  517  ASN TYR ASN THR VAL SER GLY VAL ASN GLY PRO LEU VAL          
SEQRES   4 B  517  ILE LEU GLU LYS VAL LYS PHE PRO ARG TYR ASN GLU ILE          
SEQRES   5 B  517  VAL ASN LEU THR LEU PRO ASP GLY THR VAL ARG GLN GLY          
SEQRES   6 B  517  GLN VAL LEU GLU ILE ARG GLY ASP ARG ALA ILE VAL GLN          
SEQRES   7 B  517  VAL PHE GLU GLY THR SER GLY ILE ASP VAL LYS LYS THR          
SEQRES   8 B  517  THR VAL GLU PHE THR GLY GLU SER LEU ARG ILE PRO VAL          
SEQRES   9 B  517  SER GLU ASP MET LEU GLY ARG ILE PHE ASP GLY SER GLY          
SEQRES  10 B  517  ARG PRO ILE ASP ASN GLY PRO LYS VAL PHE ALA GLU ASP          
SEQRES  11 B  517  TYR LEU ASP ILE ASN GLY SER PRO ILE ASN PRO TYR ALA          
SEQRES  12 B  517  ARG ILE TYR PRO GLU GLU MET ILE SER THR GLY VAL SER          
SEQRES  13 B  517  ALA ILE ASP THR MET ASN SER ILE ALA ARG GLY GLN LYS          
SEQRES  14 B  517  ILE PRO ILE PHE SER ALA SER GLY LEU PRO HIS ASN GLU          
SEQRES  15 B  517  ILE ALA ALA GLN ILE CYS ARG GLN ALA GLY LEU VAL ARG          
SEQRES  16 B  517  PRO THR LYS ASP VAL HIS ASP GLY HIS GLU GLU ASN PHE          
SEQRES  17 B  517  SER ILE VAL PHE ALA ALA MET GLY VAL ASN LEU GLU THR          
SEQRES  18 B  517  ALA ARG PHE PHE LYS GLN ASP PHE GLU GLU ASN GLY SER          
SEQRES  19 B  517  LEU GLU ARG THR SER LEU PHE LEU ASN LEU ALA ASN ASP          
SEQRES  20 B  517  PRO THR ILE GLU ARG ILE ILE THR PRO ARG LEU ALA LEU          
SEQRES  21 B  517  THR THR ALA GLU TYR LEU ALA TYR GLN THR GLU ARG HIS          
SEQRES  22 B  517  VAL LEU THR ILE LEU THR ASP MET SER SER TYR ALA ASP          
SEQRES  23 B  517  ALA LEU ARG GLU VAL SER ALA ALA ARG GLU GLU VAL PRO          
SEQRES  24 B  517  GLY ARG ARG GLY TYR PRO GLY TYR MET TYR THR ASP LEU          
SEQRES  25 B  517  SER THR ILE TYR GLU ARG ALA GLY ARG VAL GLU GLY ARG          
SEQRES  26 B  517  ASN GLY SER ILE THR GLN ILE PRO ILE LEU THR MET PRO          
SEQRES  27 B  517  ASN ASP ASP ILE THR HIS PRO ILE PRO ASP LEU THR GLY          
SEQRES  28 B  517  TYR ILE THR GLU GLY GLN ILE PHE VAL ASP ARG GLN LEU          
SEQRES  29 B  517  HIS ASN LYS GLY ILE TYR PRO PRO ILE ASN VAL LEU PRO          
SEQRES  30 B  517  SER LEU SER ARG LEU MET LYS SER ALA ILE GLY GLU GLY          
SEQRES  31 B  517  MET THR ARG LYS ASP HIS GLY ASP VAL SER ASN GLN LEU          
SEQRES  32 B  517  TYR ALA LYS TYR ALA ILE GLY LYS ASP ALA ALA ALA MET          
SEQRES  33 B  517  LYS ALA VAL VAL GLY GLU GLU ALA LEU SER ILE GLU ASP          
SEQRES  34 B  517  LYS LEU SER LEU GLU PHE LEU GLU LYS PHE GLU LYS THR          
SEQRES  35 B  517  PHE ILE THR GLN GLY ALA TYR GLU ASP ARG THR VAL PHE          
SEQRES  36 B  517  GLU SER LEU ASP GLN ALA TRP SER LEU LEU ARG ILE TYR          
SEQRES  37 B  517  PRO LYS GLU MET LEU ASN ARG ILE SER PRO LYS ILE LEU          
SEQRES  38 B  517  ASP GLU PHE TYR ASP ARG ALA ARG ASP ASP ALA ASP GLU          
SEQRES  39 B  517  ASP GLU GLU ASP PRO ASP THR ARG SER SER GLY LYS LYS          
SEQRES  40 B  517  LYS ASP ALA SER GLN GLU GLU SER LEU ILE                      
SEQRES   1 C  616  ALA GLY ALA ILE GLU ASN ALA ARG LYS GLU ILE LYS ARG          
SEQRES   2 C  616  ILE SER LEU GLU ASP HIS ALA GLU SER GLU TYR GLY ALA          
SEQRES   3 C  616  ILE TYR SER VAL SER GLY PRO VAL VAL ILE ALA GLU ASN          
SEQRES   4 C  616  MET ILE GLY CYS ALA MET TYR GLU LEU VAL LYS VAL GLY          
SEQRES   5 C  616  HIS ASP ASN LEU VAL GLY GLU VAL ILE ARG ILE ASP GLY          
SEQRES   6 C  616  ASP LYS ALA THR ILE GLN VAL TYR GLU GLU THR ALA GLY          
SEQRES   7 C  616  LEU THR VAL GLY ASP PRO VAL LEU ARG THR GLY LYS PRO          
SEQRES   8 C  616  LEU SER VAL GLU LEU GLY PRO GLY LEU MET GLU THR ILE          
SEQRES   9 C  616  TYR ASP GLY ILE GLN ARG PRO LEU LYS ALA ILE LYS GLU          
SEQRES  10 C  616  GLU SER GLN SER ILE TYR ILE PRO ARG GLY ILE ASP THR          
SEQRES  11 C  616  PRO ALA LEU ASP ARG THR ILE LYS TRP GLN PHE THR PRO          
SEQRES  12 C  616  GLY LYS PHE GLN VAL GLY ASP HIS ILE SER GLY GLY ASP          
SEQRES  13 C  616  ILE TYR GLY SER VAL PHE GLU ASN SER LEU ILE SER SER          
SEQRES  14 C  616  HIS LYS ILE LEU LEU PRO PRO ARG SER ARG GLY THR ILE          
SEQRES  15 C  616  THR TRP ILE ALA PRO ALA GLY GLU TYR THR LEU ASP GLU          
SEQRES  16 C  616  LYS ILE LEU GLU VAL GLU PHE ASP GLY LYS LYS SER ASP          
SEQRES  17 C  616  PHE THR LEU TYR HIS THR TRP PRO VAL ARG VAL PRO ARG          
SEQRES  18 C  616  PRO VAL THR GLU LYS LEU SER ALA ASP TYR PRO LEU LEU          
SEQRES  19 C  616  THR GLY GLN ARG VAL LEU ASP ALA LEU PHE PRO CYS VAL          
SEQRES  20 C  616  GLN GLY GLY THR THR CYS ILE PRO GLY ALA PHE GLY CYS          
SEQRES  21 C  616  GLY LYS THR VAL ILE SER GLN SER LEU SER LYS TYR SER          
SEQRES  22 C  616  ASN SER ASP ALA ILE ILE TYR VAL GLY CYS GLY GLU ARG          
SEQRES  23 C  616  GLY ASN GLU MET ALA GLU VAL LEU MET GLU PHE PRO GLU          
SEQRES  24 C  616  LEU TYR THR GLU MET SER GLY THR LYS GLU PRO ILE MET          
SEQRES  25 C  616  LYS ARG THR THR LEU VAL ALA ASN THR SER ASN MET PRO          
SEQRES  26 C  616  VAL ALA ALA ARG GLU ALA SER ILE TYR THR GLY ILE THR          
SEQRES  27 C  616  LEU ALA GLU TYR PHE ARG ASP GLN GLY LYS ASN VAL SER          
SEQRES  28 C  616  MET ILE ALA ASP SER SER SER ARG TRP ALA GLU ALA LEU          
SEQRES  29 C  616  ARG GLU ILE SER GLY ARG LEU GLY GLU MET PRO ALA ASP          
SEQRES  30 C  616  GLN GLY PHE PRO ALA TYR LEU GLY ALA LYS LEU ALA SER          
SEQRES  31 C  616  PHE TYR GLU ARG ALA GLY LYS ALA VAL ALA LEU GLY SER          
SEQRES  32 C  616  PRO ASP ARG THR GLY SER VAL SER ILE VAL ALA ALA VAL          
SEQRES  33 C  616  SER PRO ALA GLY GLY ASP PHE SER ASP PRO VAL THR THR          
SEQRES  34 C  616  ALA THR LEU GLY ILE THR GLN VAL PHE TRP GLY LEU ASP          
SEQRES  35 C  616  LYS LYS LEU ALA GLN ARG LYS HIS PHE PRO SER ILE ASN          
SEQRES  36 C  616  THR SER VAL SER TYR SER LYS TYR THR ASN VAL LEU ASN          
SEQRES  37 C  616  LYS PHE TYR ASP SER ASN TYR PRO GLU PHE PRO VAL LEU          
SEQRES  38 C  616  ARG ASP ARG MET LYS GLU ILE LEU SER ASN ALA GLU GLU          
SEQRES  39 C  616  LEU GLU GLN VAL VAL GLN LEU VAL GLY LYS SER ALA LEU          
SEQRES  40 C  616  SER ASP SER ASP LYS ILE THR LEU ASP VAL ALA THR LEU          
SEQRES  41 C  616  ILE LYS GLU ASP PHE LEU GLN GLN ASN GLY TYR SER THR          
SEQRES  42 C  616  TYR ASP ALA PHE CYS PRO ILE TRP LYS THR PHE ASP MET          
SEQRES  43 C  616  MET ARG ALA PHE ILE SER TYR HIS ASP GLU ALA GLN LYS          
SEQRES  44 C  616  ALA VAL ALA ASN GLY ALA ASN TRP SER LYS LEU ALA ASP          
SEQRES  45 C  616  SER THR GLY ASP VAL LYS HIS ALA VAL SER SER SER LYS          
SEQRES  46 C  616  PHE PHE GLU PRO SER ARG GLY GLU LYS GLU VAL HIS GLY          
SEQRES  47 C  616  GLU PHE GLU LYS LEU LEU SER THR MET GLN GLU ARG PHE          
SEQRES  48 C  616  ALA GLU SER THR ASP                                          
SEQRES   1 D  517  MET VAL LEU SER ASP LYS GLU LEU PHE ALA ILE ASN LYS          
SEQRES   2 D  517  LYS ALA VAL GLU GLN GLY PHE ASN VAL LYS PRO ARG LEU          
SEQRES   3 D  517  ASN TYR ASN THR VAL SER GLY VAL ASN GLY PRO LEU VAL          
SEQRES   4 D  517  ILE LEU GLU LYS VAL LYS PHE PRO ARG TYR ASN GLU ILE          
SEQRES   5 D  517  VAL ASN LEU THR LEU PRO ASP GLY THR VAL ARG GLN GLY          
SEQRES   6 D  517  GLN VAL LEU GLU ILE ARG GLY ASP ARG ALA ILE VAL GLN          
SEQRES   7 D  517  VAL PHE GLU GLY THR SER GLY ILE ASP VAL LYS LYS THR          
SEQRES   8 D  517  THR VAL GLU PHE THR GLY GLU SER LEU ARG ILE PRO VAL          
SEQRES   9 D  517  SER GLU ASP MET LEU GLY ARG ILE PHE ASP GLY SER GLY          
SEQRES  10 D  517  ARG PRO ILE ASP ASN GLY PRO LYS VAL PHE ALA GLU ASP          
SEQRES  11 D  517  TYR LEU ASP ILE ASN GLY SER PRO ILE ASN PRO TYR ALA          
SEQRES  12 D  517  ARG ILE TYR PRO GLU GLU MET ILE SER THR GLY VAL SER          
SEQRES  13 D  517  ALA ILE ASP THR MET ASN SER ILE ALA ARG GLY GLN LYS          
SEQRES  14 D  517  ILE PRO ILE PHE SER ALA SER GLY LEU PRO HIS ASN GLU          
SEQRES  15 D  517  ILE ALA ALA GLN ILE CYS ARG GLN ALA GLY LEU VAL ARG          
SEQRES  16 D  517  PRO THR LYS ASP VAL HIS ASP GLY HIS GLU GLU ASN PHE          
SEQRES  17 D  517  SER ILE VAL PHE ALA ALA MET GLY VAL ASN LEU GLU THR          
SEQRES  18 D  517  ALA ARG PHE PHE LYS GLN ASP PHE GLU GLU ASN GLY SER          
SEQRES  19 D  517  LEU GLU ARG THR SER LEU PHE LEU ASN LEU ALA ASN ASP          
SEQRES  20 D  517  PRO THR ILE GLU ARG ILE ILE THR PRO ARG LEU ALA LEU          
SEQRES  21 D  517  THR THR ALA GLU TYR LEU ALA TYR GLN THR GLU ARG HIS          
SEQRES  22 D  517  VAL LEU THR ILE LEU THR ASP MET SER SER TYR ALA ASP          
SEQRES  23 D  517  ALA LEU ARG GLU VAL SER ALA ALA ARG GLU GLU VAL PRO          
SEQRES  24 D  517  GLY ARG ARG GLY TYR PRO GLY TYR MET TYR THR ASP LEU          
SEQRES  25 D  517  SER THR ILE TYR GLU ARG ALA GLY ARG VAL GLU GLY ARG          
SEQRES  26 D  517  ASN GLY SER ILE THR GLN ILE PRO ILE LEU THR MET PRO          
SEQRES  27 D  517  ASN ASP ASP ILE THR HIS PRO ILE PRO ASP LEU THR GLY          
SEQRES  28 D  517  TYR ILE THR GLU GLY GLN ILE PHE VAL ASP ARG GLN LEU          
SEQRES  29 D  517  HIS ASN LYS GLY ILE TYR PRO PRO ILE ASN VAL LEU PRO          
SEQRES  30 D  517  SER LEU SER ARG LEU MET LYS SER ALA ILE GLY GLU GLY          
SEQRES  31 D  517  MET THR ARG LYS ASP HIS GLY ASP VAL SER ASN GLN LEU          
SEQRES  32 D  517  TYR ALA LYS TYR ALA ILE GLY LYS ASP ALA ALA ALA MET          
SEQRES  33 D  517  LYS ALA VAL VAL GLY GLU GLU ALA LEU SER ILE GLU ASP          
SEQRES  34 D  517  LYS LEU SER LEU GLU PHE LEU GLU LYS PHE GLU LYS THR          
SEQRES  35 D  517  PHE ILE THR GLN GLY ALA TYR GLU ASP ARG THR VAL PHE          
SEQRES  36 D  517  GLU SER LEU ASP GLN ALA TRP SER LEU LEU ARG ILE TYR          
SEQRES  37 D  517  PRO LYS GLU MET LEU ASN ARG ILE SER PRO LYS ILE LEU          
SEQRES  38 D  517  ASP GLU PHE TYR ASP ARG ALA ARG ASP ASP ALA ASP GLU          
SEQRES  39 D  517  ASP GLU GLU ASP PRO ASP THR ARG SER SER GLY LYS LYS          
SEQRES  40 D  517  LYS ASP ALA SER GLN GLU GLU SER LEU ILE                      
SEQRES   1 E  616  ALA GLY ALA ILE GLU ASN ALA ARG LYS GLU ILE LYS ARG          
SEQRES   2 E  616  ILE SER LEU GLU ASP HIS ALA GLU SER GLU TYR GLY ALA          
SEQRES   3 E  616  ILE TYR SER VAL SER GLY PRO VAL VAL ILE ALA GLU ASN          
SEQRES   4 E  616  MET ILE GLY CYS ALA MET TYR GLU LEU VAL LYS VAL GLY          
SEQRES   5 E  616  HIS ASP ASN LEU VAL GLY GLU VAL ILE ARG ILE ASP GLY          
SEQRES   6 E  616  ASP LYS ALA THR ILE GLN VAL TYR GLU GLU THR ALA GLY          
SEQRES   7 E  616  LEU THR VAL GLY ASP PRO VAL LEU ARG THR GLY LYS PRO          
SEQRES   8 E  616  LEU SER VAL GLU LEU GLY PRO GLY LEU MET GLU THR ILE          
SEQRES   9 E  616  TYR ASP GLY ILE GLN ARG PRO LEU LYS ALA ILE LYS GLU          
SEQRES  10 E  616  GLU SER GLN SER ILE TYR ILE PRO ARG GLY ILE ASP THR          
SEQRES  11 E  616  PRO ALA LEU ASP ARG THR ILE LYS TRP GLN PHE THR PRO          
SEQRES  12 E  616  GLY LYS PHE GLN VAL GLY ASP HIS ILE SER GLY GLY ASP          
SEQRES  13 E  616  ILE TYR GLY SER VAL PHE GLU ASN SER LEU ILE SER SER          
SEQRES  14 E  616  HIS LYS ILE LEU LEU PRO PRO ARG SER ARG GLY THR ILE          
SEQRES  15 E  616  THR TRP ILE ALA PRO ALA GLY GLU TYR THR LEU ASP GLU          
SEQRES  16 E  616  LYS ILE LEU GLU VAL GLU PHE ASP GLY LYS LYS SER ASP          
SEQRES  17 E  616  PHE THR LEU TYR HIS THR TRP PRO VAL ARG VAL PRO ARG          
SEQRES  18 E  616  PRO VAL THR GLU LYS LEU SER ALA ASP TYR PRO LEU LEU          
SEQRES  19 E  616  THR GLY GLN ARG VAL LEU ASP ALA LEU PHE PRO CYS VAL          
SEQRES  20 E  616  GLN GLY GLY THR THR CYS ILE PRO GLY ALA PHE GLY CYS          
SEQRES  21 E  616  GLY LYS THR VAL ILE SER GLN SER LEU SER LYS TYR SER          
SEQRES  22 E  616  ASN SER ASP ALA ILE ILE TYR VAL GLY CYS GLY GLU ARG          
SEQRES  23 E  616  GLY ASN GLU MET ALA GLU VAL LEU MET GLU PHE PRO GLU          
SEQRES  24 E  616  LEU TYR THR GLU MET SER GLY THR LYS GLU PRO ILE MET          
SEQRES  25 E  616  LYS ARG THR THR LEU VAL ALA ASN THR SER ASN MET PRO          
SEQRES  26 E  616  VAL ALA ALA ARG GLU ALA SER ILE TYR THR GLY ILE THR          
SEQRES  27 E  616  LEU ALA GLU TYR PHE ARG ASP GLN GLY LYS ASN VAL SER          
SEQRES  28 E  616  MET ILE ALA ASP SER SER SER ARG TRP ALA GLU ALA LEU          
SEQRES  29 E  616  ARG GLU ILE SER GLY ARG LEU GLY GLU MET PRO ALA ASP          
SEQRES  30 E  616  GLN GLY PHE PRO ALA TYR LEU GLY ALA LYS LEU ALA SER          
SEQRES  31 E  616  PHE TYR GLU ARG ALA GLY LYS ALA VAL ALA LEU GLY SER          
SEQRES  32 E  616  PRO ASP ARG THR GLY SER VAL SER ILE VAL ALA ALA VAL          
SEQRES  33 E  616  SER PRO ALA GLY GLY ASP PHE SER ASP PRO VAL THR THR          
SEQRES  34 E  616  ALA THR LEU GLY ILE THR GLN VAL PHE TRP GLY LEU ASP          
SEQRES  35 E  616  LYS LYS LEU ALA GLN ARG LYS HIS PHE PRO SER ILE ASN          
SEQRES  36 E  616  THR SER VAL SER TYR SER LYS TYR THR ASN VAL LEU ASN          
SEQRES  37 E  616  LYS PHE TYR ASP SER ASN TYR PRO GLU PHE PRO VAL LEU          
SEQRES  38 E  616  ARG ASP ARG MET LYS GLU ILE LEU SER ASN ALA GLU GLU          
SEQRES  39 E  616  LEU GLU GLN VAL VAL GLN LEU VAL GLY LYS SER ALA LEU          
SEQRES  40 E  616  SER ASP SER ASP LYS ILE THR LEU ASP VAL ALA THR LEU          
SEQRES  41 E  616  ILE LYS GLU ASP PHE LEU GLN GLN ASN GLY TYR SER THR          
SEQRES  42 E  616  TYR ASP ALA PHE CYS PRO ILE TRP LYS THR PHE ASP MET          
SEQRES  43 E  616  MET ARG ALA PHE ILE SER TYR HIS ASP GLU ALA GLN LYS          
SEQRES  44 E  616  ALA VAL ALA ASN GLY ALA ASN TRP SER LYS LEU ALA ASP          
SEQRES  45 E  616  SER THR GLY ASP VAL LYS HIS ALA VAL SER SER SER LYS          
SEQRES  46 E  616  PHE PHE GLU PRO SER ARG GLY GLU LYS GLU VAL HIS GLY          
SEQRES  47 E  616  GLU PHE GLU LYS LEU LEU SER THR MET GLN GLU ARG PHE          
SEQRES  48 E  616  ALA GLU SER THR ASP                                          
SEQRES   1 F  517  MET VAL LEU SER ASP LYS GLU LEU PHE ALA ILE ASN LYS          
SEQRES   2 F  517  LYS ALA VAL GLU GLN GLY PHE ASN VAL LYS PRO ARG LEU          
SEQRES   3 F  517  ASN TYR ASN THR VAL SER GLY VAL ASN GLY PRO LEU VAL          
SEQRES   4 F  517  ILE LEU GLU LYS VAL LYS PHE PRO ARG TYR ASN GLU ILE          
SEQRES   5 F  517  VAL ASN LEU THR LEU PRO ASP GLY THR VAL ARG GLN GLY          
SEQRES   6 F  517  GLN VAL LEU GLU ILE ARG GLY ASP ARG ALA ILE VAL GLN          
SEQRES   7 F  517  VAL PHE GLU GLY THR SER GLY ILE ASP VAL LYS LYS THR          
SEQRES   8 F  517  THR VAL GLU PHE THR GLY GLU SER LEU ARG ILE PRO VAL          
SEQRES   9 F  517  SER GLU ASP MET LEU GLY ARG ILE PHE ASP GLY SER GLY          
SEQRES  10 F  517  ARG PRO ILE ASP ASN GLY PRO LYS VAL PHE ALA GLU ASP          
SEQRES  11 F  517  TYR LEU ASP ILE ASN GLY SER PRO ILE ASN PRO TYR ALA          
SEQRES  12 F  517  ARG ILE TYR PRO GLU GLU MET ILE SER THR GLY VAL SER          
SEQRES  13 F  517  ALA ILE ASP THR MET ASN SER ILE ALA ARG GLY GLN LYS          
SEQRES  14 F  517  ILE PRO ILE PHE SER ALA SER GLY LEU PRO HIS ASN GLU          
SEQRES  15 F  517  ILE ALA ALA GLN ILE CYS ARG GLN ALA GLY LEU VAL ARG          
SEQRES  16 F  517  PRO THR LYS ASP VAL HIS ASP GLY HIS GLU GLU ASN PHE          
SEQRES  17 F  517  SER ILE VAL PHE ALA ALA MET GLY VAL ASN LEU GLU THR          
SEQRES  18 F  517  ALA ARG PHE PHE LYS GLN ASP PHE GLU GLU ASN GLY SER          
SEQRES  19 F  517  LEU GLU ARG THR SER LEU PHE LEU ASN LEU ALA ASN ASP          
SEQRES  20 F  517  PRO THR ILE GLU ARG ILE ILE THR PRO ARG LEU ALA LEU          
SEQRES  21 F  517  THR THR ALA GLU TYR LEU ALA TYR GLN THR GLU ARG HIS          
SEQRES  22 F  517  VAL LEU THR ILE LEU THR ASP MET SER SER TYR ALA ASP          
SEQRES  23 F  517  ALA LEU ARG GLU VAL SER ALA ALA ARG GLU GLU VAL PRO          
SEQRES  24 F  517  GLY ARG ARG GLY TYR PRO GLY TYR MET TYR THR ASP LEU          
SEQRES  25 F  517  SER THR ILE TYR GLU ARG ALA GLY ARG VAL GLU GLY ARG          
SEQRES  26 F  517  ASN GLY SER ILE THR GLN ILE PRO ILE LEU THR MET PRO          
SEQRES  27 F  517  ASN ASP ASP ILE THR HIS PRO ILE PRO ASP LEU THR GLY          
SEQRES  28 F  517  TYR ILE THR GLU GLY GLN ILE PHE VAL ASP ARG GLN LEU          
SEQRES  29 F  517  HIS ASN LYS GLY ILE TYR PRO PRO ILE ASN VAL LEU PRO          
SEQRES  30 F  517  SER LEU SER ARG LEU MET LYS SER ALA ILE GLY GLU GLY          
SEQRES  31 F  517  MET THR ARG LYS ASP HIS GLY ASP VAL SER ASN GLN LEU          
SEQRES  32 F  517  TYR ALA LYS TYR ALA ILE GLY LYS ASP ALA ALA ALA MET          
SEQRES  33 F  517  LYS ALA VAL VAL GLY GLU GLU ALA LEU SER ILE GLU ASP          
SEQRES  34 F  517  LYS LEU SER LEU GLU PHE LEU GLU LYS PHE GLU LYS THR          
SEQRES  35 F  517  PHE ILE THR GLN GLY ALA TYR GLU ASP ARG THR VAL PHE          
SEQRES  36 F  517  GLU SER LEU ASP GLN ALA TRP SER LEU LEU ARG ILE TYR          
SEQRES  37 F  517  PRO LYS GLU MET LEU ASN ARG ILE SER PRO LYS ILE LEU          
SEQRES  38 F  517  ASP GLU PHE TYR ASP ARG ALA ARG ASP ASP ALA ASP GLU          
SEQRES  39 F  517  ASP GLU GLU ASP PRO ASP THR ARG SER SER GLY LYS LYS          
SEQRES  40 F  517  LYS ASP ALA SER GLN GLU GLU SER LEU ILE                      
SEQRES   1 Q  345  MET GLU GLY VAL TYR PHE ASN ILE ASP ASN GLY PHE ILE          
SEQRES   2 Q  345  GLU GLY VAL VAL ARG GLY TYR ARG ASN GLY LEU LEU SER          
SEQRES   3 Q  345  ASN ASN GLN TYR ILE ASN LEU THR GLN CYS ASP THR LEU          
SEQRES   4 Q  345  GLU ASP LEU LYS LEU GLN LEU SER SER THR ASP TYR GLY          
SEQRES   5 Q  345  ASN PHE LEU SER SER VAL SER SER GLU SER LEU THR THR          
SEQRES   6 Q  345  SER LEU ILE GLN GLU TYR ALA SER SER LYS LEU TYR HIS          
SEQRES   7 Q  345  GLU PHE ASN TYR ILE ARG ASP GLN SER SER GLY SER THR          
SEQRES   8 Q  345  ARG LYS PHE MET ASP TYR ILE THR TYR GLY TYR MET ILE          
SEQRES   9 Q  345  ASP ASN VAL ALA LEU MET ILE THR GLY THR ILE HIS ASP          
SEQRES  10 Q  345  ARG ASP LYS GLY GLU ILE LEU GLN ARG CYS HIS PRO LEU          
SEQRES  11 Q  345  GLY TRP PHE ASP THR LEU PRO THR LEU SER VAL ALA THR          
SEQRES  12 Q  345  ASP LEU GLU SER LEU TYR GLU THR VAL LEU VAL ASP THR          
SEQRES  13 Q  345  PRO LEU ALA PRO TYR PHE LYS ASN CYS PHE ASP THR ALA          
SEQRES  14 Q  345  GLU GLU LEU ASP ASP MET ASN ILE GLU ILE ILE ARG ASN          
SEQRES  15 Q  345  LYS LEU TYR LYS ALA TYR LEU GLU ASP PHE TYR ASN PHE          
SEQRES  16 Q  345  VAL THR GLU GLU ILE PRO GLU PRO ALA LYS GLU CYS MET          
SEQRES  17 Q  345  GLN THR LEU LEU GLY PHE GLU ALA ASP ARG ARG SER ILE          
SEQRES  18 Q  345  ASN ILE ALA LEU ASN SER LEU GLN SER SER ASP ILE ASP          
SEQRES  19 Q  345  PRO ASP LEU LYS SER ASP LEU LEU PRO ASN ILE GLY LYS          
SEQRES  20 Q  345  LEU TYR PRO LEU ALA THR PHE HIS LEU ALA GLN ALA GLN          
SEQRES  21 Q  345  ASP PHE GLU GLY VAL ARG ALA ALA LEU ALA ASN VAL TYR          
SEQRES  22 Q  345  GLU TYR ARG GLY PHE LEU GLU THR GLY ASN LEU GLU ASP          
SEQRES  23 Q  345  HIS PHE TYR GLN LEU GLU MET GLU LEU CYS ARG ASP ALA          
SEQRES  24 Q  345  PHE THR GLN GLN PHE ALA ILE SER THR VAL TRP ALA TRP          
SEQRES  25 Q  345  MET LYS SER LYS GLU GLN GLU VAL ARG ASN ILE THR TRP          
SEQRES  26 Q  345  ILE ALA GLU CYS ILE ALA GLN ASN GLN ARG GLU ARG ILE          
SEQRES  27 Q  345  ASN ASN TYR ILE SER VAL TYR                                  
SEQRES   1 L  114  MET SER GLN LYS ASN GLY ILE ALA THR LEU LEU GLN ALA          
SEQRES   2 L  114  GLU LYS GLU ALA HIS GLU ILE VAL SER LYS ALA ARG LYS          
SEQRES   3 L  114  TYR ARG GLN ASP LYS LEU LYS GLN ALA LYS THR ASP ALA          
SEQRES   4 L  114  ALA LYS GLU ILE ASP SER TYR LYS ILE GLN LYS ASP LYS          
SEQRES   5 L  114  GLU LEU LYS GLU PHE GLU GLN LYS ASN ALA GLY GLY VAL          
SEQRES   6 L  114  GLY GLU LEU GLU LYS LYS ALA GLU ALA GLY VAL GLN GLY          
SEQRES   7 L  114  GLU LEU ALA GLU ILE LYS LYS ILE ALA GLU LYS LYS LYS          
SEQRES   8 L  114  ASP ASP VAL VAL LYS ILE LEU ILE GLU THR VAL ILE LYS          
SEQRES   9 L  114  PRO SER ALA GLU VAL HIS ILE ASN ALA LEU                      
SEQRES   1 K  233  MET SER SER ALA ILE THR ALA LEU THR PRO ASN GLN VAL          
SEQRES   2 K  233  ASN ASP GLU LEU ASN LYS MET GLN ALA PHE ILE ARG LYS          
SEQRES   3 K  233  GLU ALA GLU GLU LYS ALA LYS GLU ILE GLN LEU LYS ALA          
SEQRES   4 K  233  ASP GLN GLU TYR GLU ILE GLU LYS THR ASN ILE VAL ARG          
SEQRES   5 K  233  ASN GLU THR ASN ASN ILE ASP GLY ASN PHE LYS SER LYS          
SEQRES   6 K  233  LEU LYS LYS ALA MET LEU SER GLN GLN ILE THR LYS SER          
SEQRES   7 K  233  THR ILE ALA ASN LYS MET ARG LEU LYS VAL LEU SER ALA          
SEQRES   8 K  233  ARG GLU GLN SER LEU ASP GLY ILE PHE GLU GLU THR LYS          
SEQRES   9 K  233  GLU LYS LEU SER GLY ILE ALA ASN ASN ARG ASP GLU TYR          
SEQRES  10 K  233  LYS PRO ILE LEU GLN SER LEU ILE VAL GLU ALA LEU LEU          
SEQRES  11 K  233  LYS LEU LEU GLU PRO LYS ALA ILE VAL LYS ALA LEU GLU          
SEQRES  12 K  233  ARG ASP VAL ASP LEU ILE GLU SER MET LYS ASP ASP ILE          
SEQRES  13 K  233  MET ARG GLU TYR GLY GLU LYS ALA GLN ARG ALA PRO LEU          
SEQRES  14 K  233  GLU GLU ILE VAL ILE SER ASN ASP TYR LEU ASN LYS ASP          
SEQRES  15 K  233  LEU VAL SER GLY GLY VAL VAL VAL SER ASN ALA SER ASP          
SEQRES  16 K  233  LYS ILE GLU ILE ASN ASN THR LEU GLU GLU ARG LEU LYS          
SEQRES  17 K  233  LEU LEU SER GLU GLU ALA LEU PRO ALA ILE ARG LEU GLU          
SEQRES  18 K  233  LEU TYR GLY PRO SER LYS THR ARG LYS PHE PHE ASP              
SEQRES   1 P  478  MET GLY ALA THR LYS ILE LEU MET ASP SER THR HIS PHE          
SEQRES   2 P  478  ASN GLU ILE ARG SER ILE ILE ARG SER ARG SER VAL ALA          
SEQRES   3 P  478  TRP ASP ALA LEU ALA ARG SER GLU GLU LEU SER GLU ILE          
SEQRES   4 P  478  ASP ALA SER THR ALA LYS ALA LEU GLU SER ILE LEU VAL          
SEQRES   5 P  478  LYS LYS ASN ILE GLY ASP GLY LEU SER SER SER ASN ASN          
SEQRES   6 P  478  ALA HIS SER GLY PHE LYS VAL ASN GLY LYS THR LEU ILE          
SEQRES   7 P  478  PRO LEU ILE HIS LEU LEU SER THR SER ASP ASN GLU ASP          
SEQRES   8 P  478  CYS LYS LYS SER VAL GLN ASN LEU ILE ALA GLU LEU LEU          
SEQRES   9 P  478  SER SER ASP LYS TYR GLY ASP ASP THR VAL LYS PHE PHE          
SEQRES  10 P  478  GLN GLU ASP PRO LYS GLN LEU GLU GLN LEU PHE ASP VAL          
SEQRES  11 P  478  SER LEU LYS GLY ASP PHE GLN THR VAL LEU ILE SER GLY          
SEQRES  12 P  478  PHE ASN VAL VAL SER LEU LEU VAL GLN ASN GLY LEU HIS          
SEQRES  13 P  478  ASN VAL LYS LEU VAL GLU LYS LEU LEU LYS ASN ASN ASN          
SEQRES  14 P  478  LEU ILE ASN ILE LEU GLN ASN ILE GLU GLN MET ASP THR          
SEQRES  15 P  478  CYS TYR VAL CYS ILE ARG LEU LEU GLN GLU LEU ALA VAL          
SEQRES  16 P  478  ILE PRO GLU TYR ARG ASP VAL ILE TRP LEU HIS GLU LYS          
SEQRES  17 P  478  LYS PHE MET PRO THR LEU PHE LYS ILE LEU GLN ARG ALA          
SEQRES  18 P  478  THR ASP SER GLN LEU ALA THR ARG ILE VAL ALA THR ASN          
SEQRES  19 P  478  SER ASN HIS LEU GLY ILE GLN LEU GLN TYR HIS SER LEU          
SEQRES  20 P  478  LEU LEU ILE TRP LEU LEU THR PHE ASN PRO VAL PHE ALA          
SEQRES  21 P  478  ASN GLU LEU VAL GLN LYS TYR LEU SER ASP PHE LEU ASP          
SEQRES  22 P  478  LEU LEU LYS LEU VAL LYS ILE THR ILE LYS GLU LYS VAL          
SEQRES  23 P  478  SER ARG LEU CYS ILE SER ILE ILE LEU GLN CYS CYS SER          
SEQRES  24 P  478  THR ARG VAL LYS GLN HIS LYS LYS VAL ILE LYS GLN LEU          
SEQRES  25 P  478  LEU LEU LEU GLY ASN ALA LEU PRO THR VAL GLN SER LEU          
SEQRES  26 P  478  SER GLU ARG LYS TYR SER ASP GLU GLU LEU ARG GLN ASP          
SEQRES  27 P  478  ILE SER ASN LEU LYS GLU ILE LEU GLU ASN GLU TYR GLN          
SEQRES  28 P  478  GLU LEU THR SER PHE ASP GLU TYR VAL ALA GLU LEU ASP          
SEQRES  29 P  478  SER LYS LEU LEU CYS TRP SER PRO PRO HIS VAL ASP ASN          
SEQRES  30 P  478  GLY PHE TRP SER ASP ASN ILE ASP GLU PHE LYS LYS ASP          
SEQRES  31 P  478  ASN TYR LYS ILE PHE ARG GLN LEU ILE GLU LEU LEU GLN          
SEQRES  32 P  478  ALA LYS VAL ARG ASN GLY ASP VAL ASN ALA LYS GLN GLU          
SEQRES  33 P  478  LYS ILE ILE ILE GLN VAL ALA LEU ASN ASP ILE THR HIS          
SEQRES  34 P  478  VAL VAL GLU LEU LEU PRO GLU SER ILE ASP VAL LEU ASP          
SEQRES  35 P  478  LYS THR GLY GLY LYS ALA ASP ILE MET GLU LEU LEU ASN          
SEQRES  36 P  478  HIS SER ASP SER ARG VAL LYS TYR GLU ALA LEU LYS ALA          
SEQRES  37 P  478  THR GLN ALA ILE ILE GLY TYR THR PHE LYS                      
SEQRES   1 b  840  MET ALA GLU LYS GLU GLU ALA ILE PHE ARG SER ALA GLU          
SEQRES   2 b  840  MET ALA LEU VAL GLN PHE TYR ILE PRO GLN GLU ILE SER          
SEQRES   3 b  840  ARG ASP SER ALA TYR THR LEU GLY GLN LEU GLY LEU VAL          
SEQRES   4 b  840  GLN PHE ARG ASP LEU ASN SER LYS VAL ARG ALA PHE GLN          
SEQRES   5 b  840  ARG THR PHE VAL ASN GLU ILE ARG ARG LEU ASP ASN VAL          
SEQRES   6 b  840  GLU ARG GLN TYR ARG TYR PHE TYR SER LEU LEU LYS LYS          
SEQRES   7 b  840  HIS ASP ILE LYS LEU TYR GLU GLY ASP THR ASP LYS TYR          
SEQRES   8 b  840  LEU ASP GLY SER GLY GLU LEU TYR VAL PRO PRO SER GLY          
SEQRES   9 b  840  SER VAL ILE ASP ASP TYR VAL ARG ASN ALA SER TYR LEU          
SEQRES  10 b  840  GLU GLU ARG LEU ILE GLN MET GLU ASP ALA THR ASP GLN          
SEQRES  11 b  840  ILE GLU VAL GLN LYS ASN ASP LEU GLU GLN TYR ARG PHE          
SEQRES  12 b  840  ILE LEU GLN SER GLY ASP GLU PHE PHE LEU LYS GLY ASP          
SEQRES  13 b  840  ASN THR ASP SER THR SER TYR MET ASP GLU ASP MET ILE          
SEQRES  14 b  840  ASP ALA ASN GLY GLU ASN ILE ALA ALA ALA ILE GLY ALA          
SEQRES  15 b  840  SER VAL ASN TYR VAL THR GLY VAL ILE ALA ARG ASP LYS          
SEQRES  16 b  840  VAL ALA THR LEU GLU GLN ILE LEU TRP ARG VAL LEU ARG          
SEQRES  17 b  840  GLY ASN LEU PHE PHE LYS THR VAL GLU ILE GLU GLN PRO          
SEQRES  18 b  840  VAL TYR ASP VAL LYS THR ARG GLU TYR LYS HIS LYS ASN          
SEQRES  19 b  840  ALA PHE ILE VAL PHE SER HIS GLY ASP LEU ILE ILE LYS          
SEQRES  20 b  840  ARG ILE ARG LYS ILE ALA GLU SER LEU ASP ALA ASN LEU          
SEQRES  21 b  840  TYR ASP VAL ASP SER SER ASN GLU GLY ARG SER GLN GLN          
SEQRES  22 b  840  LEU ALA LYS VAL ASN LYS ASN LEU SER ASP LEU TYR THR          
SEQRES  23 b  840  VAL LEU LYS THR THR SER THR THR LEU GLU SER GLU LEU          
SEQRES  24 b  840  TYR ALA ILE ALA LYS GLU LEU ASP SER TRP PHE GLN ASP          
SEQRES  25 b  840  VAL THR ARG GLU LYS ALA ILE PHE GLU ILE LEU ASN LYS          
SEQRES  26 b  840  SER ASN TYR ASP THR ASN ARG LYS ILE LEU ILE ALA GLU          
SEQRES  27 b  840  GLY TRP ILE PRO ARG ASP GLU LEU ALA THR LEU GLN ALA          
SEQRES  28 b  840  ARG LEU GLY GLU MET ILE ALA ARG LEU GLY ILE ASP VAL          
SEQRES  29 b  840  PRO SER ILE ILE GLN VAL LEU ASP THR ASN HIS THR PRO          
SEQRES  30 b  840  PRO THR PHE HIS ARG THR ASN LYS PHE THR ALA GLY PHE          
SEQRES  31 b  840  GLN SER ILE CYS ASP CYS TYR GLY ILE ALA GLN TYR ARG          
SEQRES  32 b  840  GLU ILE ASN ALA GLY LEU PRO THR ILE VAL THR PHE PRO          
SEQRES  33 b  840  PHE MET PHE ALA ILE MET PHE GLY ASP MET GLY HIS GLY          
SEQRES  34 b  840  PHE LEU MET THR LEU ALA ALA LEU SER LEU VAL LEU ASN          
SEQRES  35 b  840  GLU LYS LYS ILE ASN LYS MET LYS ARG GLY GLU ILE PHE          
SEQRES  36 b  840  ASP MET ALA PHE THR GLY ARG TYR ILE ILE LEU LEU MET          
SEQRES  37 b  840  GLY VAL PHE SER MET TYR THR GLY PHE LEU TYR ASN ASP          
SEQRES  38 b  840  ILE PHE SER LYS THR MET THR ILE PHE LYS SER GLY TRP          
SEQRES  39 b  840  LYS TRP PRO ASP HIS TRP LYS LYS GLY GLU SER ILE THR          
SEQRES  40 b  840  ALA THR SER VAL GLY THR TYR PRO ILE GLY LEU ASP TRP          
SEQRES  41 b  840  ALA TRP HIS GLY THR GLU ASN ALA LEU LEU PHE SER ASN          
SEQRES  42 b  840  SER TYR LYS MET LYS LEU SER ILE LEU MET GLY PHE ILE          
SEQRES  43 b  840  HIS MET THR TYR SER TYR PHE PHE SER LEU ALA ASN HIS          
SEQRES  44 b  840  LEU TYR PHE ASN SER MET ILE ASP ILE ILE GLY ASN PHE          
SEQRES  45 b  840  ILE PRO GLY LEU LEU PHE MET GLN GLY ILE PHE GLY TYR          
SEQRES  46 b  840  LEU SER VAL CYS ILE VAL TYR LYS TRP ALA VAL ASP TRP          
SEQRES  47 b  840  VAL LYS ASP GLY LYS PRO ALA PRO GLY LEU LEU ASN MET          
SEQRES  48 b  840  LEU ILE ASN MET PHE LEU SER PRO GLY THR ILE ASP ASP          
SEQRES  49 b  840  GLU LEU TYR PRO HIS GLN ALA LYS VAL GLN VAL PHE LEU          
SEQRES  50 b  840  LEU LEU MET ALA LEU VAL CYS ILE PRO TRP LEU LEU LEU          
SEQRES  51 b  840  VAL LYS PRO LEU HIS PHE LYS PHE THR HIS LYS LYS LYS          
SEQRES  52 b  840  SER HIS GLU PRO LEU PRO SER THR GLU ALA ASP ALA SER          
SEQRES  53 b  840  SER GLU ASP LEU GLU ALA GLN GLN LEU ILE SER ALA MET          
SEQRES  54 b  840  ASP ALA ASP ASP ALA GLU GLU GLU GLU VAL GLY SER GLY          
SEQRES  55 b  840  SER HIS GLY GLU ASP PHE GLY ASP ILE MET ILE HIS GLN          
SEQRES  56 b  840  VAL ILE HIS THR ILE GLU PHE CYS LEU ASN CYS VAL SER          
SEQRES  57 b  840  HIS THR ALA SER TYR LEU ARG LEU TRP ALA LEU SER LEU          
SEQRES  58 b  840  ALA HIS ALA GLN LEU SER SER VAL LEU TRP THR MET THR          
SEQRES  59 b  840  ILE GLN ILE ALA PHE GLY PHE ARG GLY PHE VAL GLY VAL          
SEQRES  60 b  840  PHE MET THR VAL ALA LEU PHE ALA MET TRP PHE ALA LEU          
SEQRES  61 b  840  THR CYS ALA VAL LEU VAL LEU MET GLU GLY THR SER ALA          
SEQRES  62 b  840  MET LEU HIS SER LEU ARG LEU HIS TRP VAL GLU SER MET          
SEQRES  63 b  840  SER LYS PHE PHE VAL GLY GLU GLY LEU PRO TYR GLU PRO          
SEQRES  64 b  840  PHE ALA PHE GLU TYR LYS ASP MET GLU VAL ALA VAL ALA          
SEQRES  65 b  840  SER ALA SER SER SER ALA SER SER                              
SEQRES   1 O  392  MET ALA THR ALA LEU TYR THR ALA ASN ASP PHE ILE LEU          
SEQRES   2 O  392  ILE SER LEU PRO GLN ASN ALA GLN PRO VAL THR ALA PRO          
SEQRES   3 O  392  GLY SER LYS THR ASP SER TRP PHE ASN GLU THR LEU ILE          
SEQRES   4 O  392  GLY GLY ARG ALA PHE VAL SER ASP PHE LYS ILE PRO GLU          
SEQRES   5 O  392  PHE LYS ILE GLY SER LEU ASP THR LEU ILE VAL GLU SER          
SEQRES   6 O  392  GLU GLU LEU SER LYS VAL ASP ASN GLN ILE GLY ALA SER          
SEQRES   7 O  392  ILE GLY LYS ILE ILE GLU ILE LEU GLN GLY LEU ASN GLU          
SEQRES   8 O  392  THR SER THR ASN ALA TYR ARG THR LEU PRO ILE ASN ASN          
SEQRES   9 O  392  MET PRO VAL PRO GLU TYR LEU GLU ASN PHE GLN TRP GLN          
SEQRES  10 O  392  THR ARG LYS PHE LYS LEU ASP LYS SER ILE LYS ASP LEU          
SEQRES  11 O  392  ILE THR LEU ILE SER ASN GLU SER SER GLN LEU ASP ALA          
SEQRES  12 O  392  ASP VAL ARG ALA THR TYR ALA ASN TYR ASN SER ALA LYS          
SEQRES  13 O  392  THR ASN LEU ALA ALA ALA GLU ARG LYS LYS THR GLY ASP          
SEQRES  14 O  392  LEU SER VAL ARG SER LEU HIS ASP ILE VAL LYS PRO GLU          
SEQRES  15 O  392  ASP PHE VAL LEU ASN SER GLU HIS LEU THR THR VAL LEU          
SEQRES  16 O  392  VAL ALA VAL PRO LYS SER LEU LYS SER ASP PHE GLU LYS          
SEQRES  17 O  392  SER TYR GLU THR LEU SER LYS ASN VAL VAL PRO ALA SER          
SEQRES  18 O  392  ALA SER VAL ILE ALA GLU ASP ALA GLU TYR VAL LEU PHE          
SEQRES  19 O  392  ASN VAL HIS LEU PHE LYS LYS ASN VAL GLN GLU PHE THR          
SEQRES  20 O  392  THR ALA ALA ARG GLU LYS LYS PHE ILE PRO ARG GLU PHE          
SEQRES  21 O  392  ASN TYR SER GLU GLU LEU ILE ASP GLN LEU LYS LYS GLU          
SEQRES  22 O  392  HIS ASP SER ALA ALA SER LEU GLU GLN SER LEU ARG VAL          
SEQRES  23 O  392  GLN LEU VAL ARG LEU ALA LYS THR ALA TYR VAL ASP VAL          
SEQRES  24 O  392  PHE ILE ASN TRP PHE HIS ILE LYS ALA LEU ARG VAL TYR          
SEQRES  25 O  392  VAL GLU SER VAL LEU ARG TYR GLY LEU PRO PRO HIS PHE          
SEQRES  26 O  392  ASN ILE LYS ILE ILE ALA VAL PRO PRO LYS ASN LEU SER          
SEQRES  27 O  392  LYS CYS LYS SER GLU LEU ILE ASP ALA PHE GLY PHE LEU          
SEQRES  28 O  392  GLY GLY ASN ALA PHE MET LYS ASP LYS LYS GLY LYS ILE          
SEQRES  29 O  392  ASN LYS GLN ASP THR SER LEU HIS GLN TYR ALA SER LEU          
SEQRES  30 O  392  VAL ASP THR GLU TYR GLU PRO PHE VAL MET TYR ILE ILE          
SEQRES  31 O  392  ASN LEU                                                      
SEQRES   1 H  114  MET SER GLN LYS ASN GLY ILE ALA THR LEU LEU GLN ALA          
SEQRES   2 H  114  GLU LYS GLU ALA HIS GLU ILE VAL SER LYS ALA ARG LYS          
SEQRES   3 H  114  TYR ARG GLN ASP LYS LEU LYS GLN ALA LYS THR ASP ALA          
SEQRES   4 H  114  ALA LYS GLU ILE ASP SER TYR LYS ILE GLN LYS ASP LYS          
SEQRES   5 H  114  GLU LEU LYS GLU PHE GLU GLN LYS ASN ALA GLY GLY VAL          
SEQRES   6 H  114  GLY GLU LEU GLU LYS LYS ALA GLU ALA GLY VAL GLN GLY          
SEQRES   7 H  114  GLU LEU ALA GLU ILE LYS LYS ILE ALA GLU LYS LYS LYS          
SEQRES   8 H  114  ASP ASP VAL VAL LYS ILE LEU ILE GLU THR VAL ILE LYS          
SEQRES   9 H  114  PRO SER ALA GLU VAL HIS ILE ASN ALA LEU                      
SEQRES   1 G  233  MET SER SER ALA ILE THR ALA LEU THR PRO ASN GLN VAL          
SEQRES   2 G  233  ASN ASP GLU LEU ASN LYS MET GLN ALA PHE ILE ARG LYS          
SEQRES   3 G  233  GLU ALA GLU GLU LYS ALA LYS GLU ILE GLN LEU LYS ALA          
SEQRES   4 G  233  ASP GLN GLU TYR GLU ILE GLU LYS THR ASN ILE VAL ARG          
SEQRES   5 G  233  ASN GLU THR ASN ASN ILE ASP GLY ASN PHE LYS SER LYS          
SEQRES   6 G  233  LEU LYS LYS ALA MET LEU SER GLN GLN ILE THR LYS SER          
SEQRES   7 G  233  THR ILE ALA ASN LYS MET ARG LEU LYS VAL LEU SER ALA          
SEQRES   8 G  233  ARG GLU GLN SER LEU ASP GLY ILE PHE GLU GLU THR LYS          
SEQRES   9 G  233  GLU LYS LEU SER GLY ILE ALA ASN ASN ARG ASP GLU TYR          
SEQRES  10 G  233  LYS PRO ILE LEU GLN SER LEU ILE VAL GLU ALA LEU LEU          
SEQRES  11 G  233  LYS LEU LEU GLU PRO LYS ALA ILE VAL LYS ALA LEU GLU          
SEQRES  12 G  233  ARG ASP VAL ASP LEU ILE GLU SER MET LYS ASP ASP ILE          
SEQRES  13 G  233  MET ARG GLU TYR GLY GLU LYS ALA GLN ARG ALA PRO LEU          
SEQRES  14 G  233  GLU GLU ILE VAL ILE SER ASN ASP TYR LEU ASN LYS ASP          
SEQRES  15 G  233  LEU VAL SER GLY GLY VAL VAL VAL SER ASN ALA SER ASP          
SEQRES  16 G  233  LYS ILE GLU ILE ASN ASN THR LEU GLU GLU ARG LEU LYS          
SEQRES  17 G  233  LEU LEU SER GLU GLU ALA LEU PRO ALA ILE ARG LEU GLU          
SEQRES  18 G  233  LEU TYR GLY PRO SER LYS THR ARG LYS PHE PHE ASP              
SEQRES   1 J  114  MET SER GLN LYS ASN GLY ILE ALA THR LEU LEU GLN ALA          
SEQRES   2 J  114  GLU LYS GLU ALA HIS GLU ILE VAL SER LYS ALA ARG LYS          
SEQRES   3 J  114  TYR ARG GLN ASP LYS LEU LYS GLN ALA LYS THR ASP ALA          
SEQRES   4 J  114  ALA LYS GLU ILE ASP SER TYR LYS ILE GLN LYS ASP LYS          
SEQRES   5 J  114  GLU LEU LYS GLU PHE GLU GLN LYS ASN ALA GLY GLY VAL          
SEQRES   6 J  114  GLY GLU LEU GLU LYS LYS ALA GLU ALA GLY VAL GLN GLY          
SEQRES   7 J  114  GLU LEU ALA GLU ILE LYS LYS ILE ALA GLU LYS LYS LYS          
SEQRES   8 J  114  ASP ASP VAL VAL LYS ILE LEU ILE GLU THR VAL ILE LYS          
SEQRES   9 J  114  PRO SER ALA GLU VAL HIS ILE ASN ALA LEU                      
SEQRES   1 I  233  MET SER SER ALA ILE THR ALA LEU THR PRO ASN GLN VAL          
SEQRES   2 I  233  ASN ASP GLU LEU ASN LYS MET GLN ALA PHE ILE ARG LYS          
SEQRES   3 I  233  GLU ALA GLU GLU LYS ALA LYS GLU ILE GLN LEU LYS ALA          
SEQRES   4 I  233  ASP GLN GLU TYR GLU ILE GLU LYS THR ASN ILE VAL ARG          
SEQRES   5 I  233  ASN GLU THR ASN ASN ILE ASP GLY ASN PHE LYS SER LYS          
SEQRES   6 I  233  LEU LYS LYS ALA MET LEU SER GLN GLN ILE THR LYS SER          
SEQRES   7 I  233  THR ILE ALA ASN LYS MET ARG LEU LYS VAL LEU SER ALA          
SEQRES   8 I  233  ARG GLU GLN SER LEU ASP GLY ILE PHE GLU GLU THR LYS          
SEQRES   9 I  233  GLU LYS LEU SER GLY ILE ALA ASN ASN ARG ASP GLU TYR          
SEQRES  10 I  233  LYS PRO ILE LEU GLN SER LEU ILE VAL GLU ALA LEU LEU          
SEQRES  11 I  233  LYS LEU LEU GLU PRO LYS ALA ILE VAL LYS ALA LEU GLU          
SEQRES  12 I  233  ARG ASP VAL ASP LEU ILE GLU SER MET LYS ASP ASP ILE          
SEQRES  13 I  233  MET ARG GLU TYR GLY GLU LYS ALA GLN ARG ALA PRO LEU          
SEQRES  14 I  233  GLU GLU ILE VAL ILE SER ASN ASP TYR LEU ASN LYS ASP          
SEQRES  15 I  233  LEU VAL SER GLY GLY VAL VAL VAL SER ASN ALA SER ASP          
SEQRES  16 I  233  LYS ILE GLU ILE ASN ASN THR LEU GLU GLU ARG LEU LYS          
SEQRES  17 I  233  LEU LEU SER GLU GLU ALA LEU PRO ALA ILE ARG LEU GLU          
SEQRES  18 I  233  LEU TYR GLY PRO SER LYS THR ARG LYS PHE PHE ASP              
SEQRES   1 Y  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 Y  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 Y  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 Y  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 Y  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 Y  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 Y  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 Y  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 Y  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 Y  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 Y  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 Y  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 Y  160  ASP VAL VAL CYS                                              
SEQRES   1 R  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 R  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 R  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 R  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 R  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 R  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 R  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 R  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 R  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 R  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 R  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 R  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 R  160  ASP VAL VAL CYS                                              
SEQRES   1 U  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 U  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 U  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 U  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 U  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 U  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 U  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 U  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 U  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 U  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 U  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 U  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 U  160  ASP VAL VAL CYS                                              
SEQRES   1 V  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 V  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 V  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 V  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 V  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 V  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 V  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 V  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 V  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 V  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 V  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 V  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 V  160  ASP VAL VAL CYS                                              
SEQRES   1 T  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 T  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 T  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 T  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 T  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 T  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 T  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 T  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 T  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 T  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 T  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 T  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 T  160  ASP VAL VAL CYS                                              
SEQRES   1 W  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 W  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 W  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 W  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 W  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 W  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 W  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 W  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 W  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 W  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 W  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 W  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 W  160  ASP VAL VAL CYS                                              
SEQRES   1 S  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 S  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 S  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 S  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 S  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 S  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 S  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 S  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 S  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 S  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 S  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 S  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 S  160  ASP VAL VAL CYS                                              
SEQRES   1 X  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 X  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 X  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 X  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 X  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 X  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 X  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 X  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 X  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 X  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 X  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 X  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 X  160  ASP VAL VAL CYS                                              
SEQRES   1 Z  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 Z  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 Z  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 Z  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 Z  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 Z  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 Z  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 Z  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 Z  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 Z  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 Z  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 Z  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 Z  160  ASP VAL VAL CYS                                              
SEQRES   1 a  160  MET THR GLU LEU CYS PRO VAL TYR ALA PRO PHE PHE GLY          
SEQRES   2 a  160  ALA ILE GLY CYS ALA SER ALA ILE ILE PHE THR SER LEU          
SEQRES   3 a  160  GLY ALA ALA TYR GLY THR ALA LYS SER GLY VAL GLY ILE          
SEQRES   4 a  160  CYS ALA THR CYS VAL LEU ARG PRO ASP LEU LEU PHE LYS          
SEQRES   5 a  160  ASN ILE VAL PRO VAL ILE MET ALA GLY ILE ILE ALA ILE          
SEQRES   6 a  160  TYR GLY LEU VAL VAL SER VAL LEU VAL CYS TYR SER LEU          
SEQRES   7 a  160  GLY GLN LYS GLN ALA LEU TYR THR GLY PHE ILE GLN LEU          
SEQRES   8 a  160  GLY ALA GLY LEU SER VAL GLY LEU SER GLY LEU ALA ALA          
SEQRES   9 a  160  GLY PHE ALA ILE GLY ILE VAL GLY ASP ALA GLY VAL ARG          
SEQRES  10 a  160  GLY SER SER GLN GLN PRO ARG LEU PHE VAL GLY MET ILE          
SEQRES  11 a  160  LEU ILE LEU ILE PHE ALA GLU VAL LEU GLY LEU TYR GLY          
SEQRES  12 a  160  LEU ILE VAL ALA LEU LEU LEU ASN SER ARG ALA THR GLN          
SEQRES  13 a  160  ASP VAL VAL CYS                                              
HELIX    1   1 THR M   14  GLY M   76  1                                  63    
HELIX    2   2 ASN M   78  VAL M   87  1                                  10    
HELIX    3   3 GLY M  126  VAL M  176  1                                  51    
HELIX    4   4 VAL M  176  LEU M  217  1                                  42    
HELIX    5   5 ASP N   13  ALA N   23  1                                  11    
HELIX    6   6 THR N   46  GLU N   59  1                                  14    
HELIX    7   7 GLN N   71  ILE N   77  1                                   7    
HELIX    8   8 ILE N   77  PHE N   84  1                                   8    
HELIX    9   9 ASP N  102  LYS N  105  5                                   4    
HELIX   10  10 ASP N  106  LYS N  114  1                                   9    
HELIX   11  11 PRO A  111  SER A  119  1                                   9    
HELIX   12  12 GLN A  237  PHE A  244  1                                   8    
HELIX   13  13 GLY A  261  SER A  273  1                                  13    
HELIX   14  14 GLY A  287  LEU A  300  1                                  14    
HELIX   15  15 GLU A  309  ARG A  314  1                                   6    
HELIX   16  16 PRO A  325  ASP A  345  1                                  21    
HELIX   17  17 SER A  356  GLY A  372  1                                  17    
HELIX   18  18 ALA A  376  PHE A  380  5                                   5    
HELIX   19  19 TYR A  383  ALA A  395  1                                  13    
HELIX   20  20 ASP A  425  THR A  435  1                                  11    
HELIX   21  21 ASP A  442  LYS A  449  1                                   8    
HELIX   22  22 TYR A  463  TYR A  475  1                                  13    
HELIX   23  23 GLU A  477  VAL A  502  1                                  26    
HELIX   24  24 SER A  508  LEU A  526  1                                  19    
HELIX   25  25 PRO A  539  ALA A  565  1                                  27    
HELIX   26  26 ASN A  566  SER A  583  1                                  18    
HELIX   27  27 HIS A  597  ASP A  616  1                                  20    
HELIX   28  28 VAL B  155  THR B  160  1                                   6    
HELIX   29  29 PRO B  179  ALA B  191  1                                  13    
HELIX   30  30 VAL B  194  ASP B  202  1                                   9    
HELIX   31  31 ASN B  218  GLY B  233  1                                  16    
HELIX   32  32 SER B  234  GLU B  236  5                                   3    
HELIX   33  33 PRO B  248  THR B  270  1                                  23    
HELIX   34  34 ASP B  280  VAL B  291  1                                  12    
HELIX   35  35 GLY B  300  TYR B  304  5                                   5    
HELIX   36  36 TYR B  307  GLU B  317  1                                  11    
HELIX   37  37 HIS B  344  THR B  354  1                                  11    
HELIX   38  38 ASP B  361  GLY B  368  1                                   8    
HELIX   39  39 LEU B  382  ILE B  387  1                                   6    
HELIX   40  40 ASP B  395  GLY B  421  1                                  27    
HELIX   41  41 SER B  426  PHE B  443  1                                  18    
HELIX   42  42 THR B  453  ARG B  466  1                                  14    
HELIX   43  43 SER B  477  PHE B  484  1                                   8    
HELIX   44  44 PRO C  111  SER C  119  1                                   9    
HELIX   45  45 GLN C  237  PHE C  244  1                                   8    
HELIX   46  46 GLY C  261  SER C  273  1                                  13    
HELIX   47  47 GLY C  287  LEU C  300  1                                  14    
HELIX   48  48 GLU C  309  ARG C  314  1                                   6    
HELIX   49  49 PRO C  325  GLY C  347  1                                  23    
HELIX   50  50 SER C  356  GLY C  372  1                                  17    
HELIX   51  51 TYR C  383  ARG C  394  1                                  12    
HELIX   52  52 ASP C  425  THR C  435  1                                  11    
HELIX   53  53 ASP C  442  LYS C  449  1                                   8    
HELIX   54  54 ASN C  455  SER C  459  5                                   5    
HELIX   55  55 TYR C  463  TYR C  475  1                                  13    
HELIX   56  56 PHE C  478  GLY C  503  1                                  26    
HELIX   57  57 SER C  508  PHE C  525  1                                  18    
HELIX   58  58 PRO C  539  GLY C  564  1                                  26    
HELIX   59  59 ASN C  566  SER C  583  1                                  18    
HELIX   60  60 HIS C  597  ASP C  616  1                                  20    
HELIX   61  61 VAL D  155  THR D  160  1                                   6    
HELIX   62  62 PRO D  179  ALA D  191  1                                  13    
HELIX   63  63 VAL D  194  ASP D  202  1                                   9    
HELIX   64  64 ASN D  218  GLY D  233  1                                  16    
HELIX   65  65 PRO D  248  THR D  270  1                                  23    
HELIX   66  66 ASP D  280  VAL D  291  1                                  12    
HELIX   67  67 GLY D  300  TYR D  304  5                                   5    
HELIX   68  68 PRO D  305  GLY D  306  5                                   2    
HELIX   69  69 TYR D  307  GLU D  317  1                                  11    
HELIX   70  70 HIS D  344  THR D  354  1                                  11    
HELIX   71  71 ASP D  361  GLY D  368  1                                   8    
HELIX   72  72 LEU D  382  ILE D  387  1                                   6    
HELIX   73  73 LYS D  394  VAL D  420  1                                  27    
HELIX   74  74 SER D  426  PHE D  443  1                                  18    
HELIX   75  75 THR D  453  ARG D  466  1                                  14    
HELIX   76  76 SER D  477  TYR D  485  1                                   9    
HELIX   77  77 PRO E  111  GLN E  120  1                                  10    
HELIX   78  78 GLN E  237  PHE E  244  1                                   8    
HELIX   79  79 GLY E  261  SER E  273  1                                  13    
HELIX   80  80 GLY E  287  LEU E  300  1                                  14    
HELIX   81  81 GLU E  309  ARG E  314  1                                   6    
HELIX   82  82 PRO E  325  GLY E  347  1                                  23    
HELIX   83  83 SER E  356  GLY E  372  1                                  17    
HELIX   84  84 ALA E  376  PRO E  381  5                                   6    
HELIX   85  85 ALA E  382  ARG E  394  1                                  13    
HELIX   86  86 ASP E  425  THR E  435  1                                  11    
HELIX   87  87 ASP E  442  ARG E  448  1                                   7    
HELIX   88  88 ASN E  455  SER E  459  5                                   5    
HELIX   89  89 TYR E  463  TYR E  475  1                                  13    
HELIX   90  90 GLU E  477  VAL E  502  1                                  26    
HELIX   91  91 SER E  508  GLN E  527  1                                  20    
HELIX   92  92 PRO E  539  ALA E  565  1                                  27    
HELIX   93  93 ASN E  566  GLY E  575  1                                  10    
HELIX   94  94 GLY E  575  SER E  583  1                                   9    
HELIX   95  95 SER E  584  PHE E  587  5                                   4    
HELIX   96  96 HIS E  597  ASP E  616  1                                  20    
HELIX   97  97 VAL F  155  THR F  160  1                                   6    
HELIX   98  98 PRO F  179  ALA F  191  1                                  13    
HELIX   99  99 VAL F  194  HIS F  201  1                                   8    
HELIX  100 100 ASN F  218  GLY F  233  1                                  16    
HELIX  101 101 PRO F  248  GLU F  271  1                                  24    
HELIX  102 102 ASP F  280  ALA F  294  1                                  15    
HELIX  103 103 GLY F  300  TYR F  304  5                                   5    
HELIX  104 104 TYR F  307  GLU F  317  1                                  11    
HELIX  105 105 HIS F  344  THR F  354  1                                  11    
HELIX  106 106 ASP F  361  GLY F  368  1                                   8    
HELIX  107 107 LEU F  382  ILE F  387  1                                   6    
HELIX  108 108 LYS F  394  GLY F  421  1                                  28    
HELIX  109 109 SER F  426  PHE F  443  1                                  18    
HELIX  110 110 THR F  453  ARG F  466  1                                  14    
HELIX  111 111 SER F  477  PHE F  484  1                                   8    
HELIX  112 112 ASN Q    7  ASN Q   22  1                                  16    
HELIX  113 113 SER Q   26  CYS Q   36  1                                  11    
HELIX  114 114 THR Q   38  SER Q   48  1                                  11    
HELIX  115 115 TYR Q   51  SER Q   56  1                                   6    
HELIX  116 116 THR Q   64  PHE Q   80  1                                  17    
HELIX  117 117 PHE Q   80  GLN Q   86  1                                   7    
HELIX  118 118 SER Q   88  ASP Q  117  1                                  30    
HELIX  119 119 THR Q  135  ALA Q  142  1                                   8    
HELIX  120 120 ASP Q  144  ASP Q  155  1                                  12    
HELIX  121 121 PRO Q  160  GLU Q  170  1                                  11    
HELIX  122 122 ASN Q  176  ILE Q  200  1                                  25    
HELIX  123 123 GLU Q  206  LEU Q  228  1                                  23    
HELIX  124 124 TYR Q  249  GLN Q  258  1                                  10    
HELIX  125 125 GLU Q  263  ALA Q  270  1                                   8    
HELIX  126 126 GLU Q  280  GLU Q  294  1                                  15    
HELIX  127 127 LEU Q  295  PHE Q  300  1                                   6    
HELIX  128 128 ALA Q  305  GLN Q  332  1                                  28    
HELIX  129 129 ARG Q  337  ILE Q  342  1                                   6    
HELIX  130 130 GLN L    3  GLN L   59  1                                  57    
HELIX  131 131 LYS L   60  ALA L   62  5                                   3    
HELIX  132 132 GLY L   63  ALA L   74  1                                  12    
HELIX  133 133 GLY L   75  GLN L   77  5                                   3    
HELIX  134 134 GLY L   78  LYS L   90  1                                  13    
HELIX  135 135 LYS L   90  ILE L  103  1                                  14    
HELIX  136 136 THR K    9  ASN K  112  1                                 104    
HELIX  137 137 ASN K  113  LEU K  130  1                                  18    
HELIX  138 138 ASP K  145  SER K  151  1                                   7    
HELIX  139 139 MET K  152  LYS K  163  1                                  12    
HELIX  140 140 LEU K  203  TYR K  223  1                                  21    
HELIX  141 141 SER P   10  ARG P   23  1                                  14    
HELIX  142 142 ALA P   26  GLU P   34  1                                   9    
HELIX  143 143 SER P   37  LYS P   54  1                                  18    
HELIX  144 144 THR P   76  SER P   87  1                                  12    
HELIX  145 145 ASN P   89  SER P  106  1                                  18    
HELIX  146 146 ASP P  111  ASP P  120  1                                  10    
HELIX  147 147 ASP P  120  VAL P  130  1                                  11    
HELIX  148 148 ASP P  135  VAL P  151  1                                  17    
HELIX  149 149 ASN P  157  ASN P  167  1                                  11    
HELIX  150 150 ASN P  167  ASN P  176  1                                  10    
HELIX  151 151 GLN P  179  ILE P  196  1                                  18    
HELIX  152 152 ILE P  196  HIS P  206  1                                  11    
HELIX  153 153 HIS P  206  SER P  224  1                                  19    
HELIX  154 154 ASN P  236  THR P  254  1                                  19    
HELIX  155 155 ASN P  256  TYR P  267  1                                  12    
HELIX  156 156 TYR P  267  LEU P  272  1                                   6    
HELIX  157 157 ASP P  273  THR P  281  1                                   9    
HELIX  158 158 LYS P  283  SER P  299  1                                  17    
HELIX  159 159 GLN P  304  LEU P  315  1                                  12    
HELIX  160 160 ASN P  317  ARG P  328  1                                  12    
HELIX  161 161 ASP P  332  GLU P  352  1                                  21    
HELIX  162 162 THR P  354  LYS P  366  1                                  13    
HELIX  163 163 ASP P  376  LYS P  388  1                                  13    
HELIX  164 164 TYR P  392  ASN P  408  1                                  17    
HELIX  165 165 ALA P  413  LEU P  434  1                                  22    
HELIX  166 166 SER P  437  GLY P  445  1                                   9    
HELIX  167 167 GLY P  445  LEU P  454  1                                  10    
HELIX  168 168 ASP P  458  PHE P  477  1                                  20    
HELIX  169 169 ILE b   25  GLN b   35  1                                  11    
HELIX  170 170 PHE b   55  ASP b   80  1                                  26    
HELIX  171 171 ASP b   93  TYR b   99  1                                   7    
HELIX  172 172 VAL b  106  PHE b  151  1                                  46    
HELIX  173 173 ARG b  193  ARG b  208  1                                  16    
HELIX  174 174 ILE b  245  LEU b  256  1                                  12    
HELIX  175 175 GLN b  272  ASN b  324  1                                  53    
HELIX  176 176 SER b  326  ASN b  331  1                                   6    
HELIX  177 177 GLU b  345  GLN b  350  1                                   6    
HELIX  178 178 LYS O   29  THR O   37  1                                   9    
HELIX  179 179 LEU O   38  ARG O   42  5                                   5    
HELIX  180 180 SER O   57  ASN O   90  1                                  34    
HELIX  181 181 PRO O  106  PHE O  114  1                                   9    
HELIX  182 182 SER O  126  THR O  167  1                                  42    
HELIX  183 183 LEU O  202  TYR O  210  1                                   9    
HELIX  184 184 ASN O  242  LYS O  254  1                                  13    
HELIX  185 185 SER O  263  GLY O  320  1                                  58    
HELIX  186 186 ASN O  336  GLY O  349  1                                  14    
HELIX  187 187 PHE O  350  GLY O  352  5                                   3    
HELIX  188 188 GLN H    3  GLY H   64  1                                  62    
HELIX  189 189 GLY H   66  VAL H   76  1                                  11    
HELIX  190 190 GLU H   79  LYS H   90  1                                  12    
HELIX  191 191 LYS H   90  ILE H  103  1                                  14    
HELIX  192 192 THR G    9  ASN G  112  1                                 104    
HELIX  193 193 ASN G  113  LEU G  130  1                                  18    
HELIX  194 194 ASP G  145  SER G  151  1                                   7    
HELIX  195 195 MET G  152  ALA G  164  1                                  13    
HELIX  196 196 LEU G  203  TYR G  223  1                                  21    
HELIX  197 197 GLN J    3  LYS J   60  1                                  58    
HELIX  198 198 GLY J   66  ALA J   74  1                                   9    
HELIX  199 199 GLY J   78  LYS J   90  1                                  13    
HELIX  200 200 LYS J   90  LYS J  104  1                                  15    
HELIX  201 201 THR I    9  ASN I  112  1                                 104    
HELIX  202 202 ASN I  113  LEU I  130  1                                  18    
HELIX  203 203 ASP I  145  SER I  151  1                                   7    
HELIX  204 204 MET I  152  ALA I  164  1                                  13    
HELIX  205 205 LEU I  203  GLY I  224  1                                  22    
HELIX  206 206 PHE Y   12  VAL Y   44  1                                  33    
HELIX  207 207 LEU Y   49  ILE Y   62  1                                  14    
HELIX  208 208 ILE Y   62  SER Y   77  1                                  16    
HELIX  209 209 ALA Y   83  GLN Y  122  1                                  40    
HELIX  210 210 LEU Y  125  THR Y  155  1                                  31    
HELIX  211 211 PHE R   12  CYS R   43  1                                  32    
HELIX  212 212 LEU R   49  ALA R   60  1                                  12    
HELIX  213 213 ILE R   62  SER R   77  1                                  16    
HELIX  214 214 ALA R   83  GLN R  122  1                                  40    
HELIX  215 215 PRO R  123  LEU R  125  5                                   3    
HELIX  216 216 PHE R  126  THR R  155  1                                  30    
HELIX  217 217 PHE U   12  ARG U   46  1                                  35    
HELIX  218 218 LEU U   49  ALA U   60  1                                  12    
HELIX  219 219 ILE U   62  SER U   77  1                                  16    
HELIX  220 220 ALA U   83  GLN U  122  1                                  40    
HELIX  221 221 LEU U  125  THR U  155  1                                  31    
HELIX  222 222 PHE V   12  ARG V   46  1                                  35    
HELIX  223 223 LEU V   49  ALA V   60  1                                  12    
HELIX  224 224 GLY V   61  LEU V   78  1                                  18    
HELIX  225 225 ALA V   83  GLN V  122  1                                  40    
HELIX  226 226 LEU V  125  ALA V  136  1                                  12    
HELIX  227 227 GLU V  137  THR V  155  1                                  19    
HELIX  228 228 PHE T   12  ARG T   46  1                                  35    
HELIX  229 229 LEU T   49  ILE T   54  1                                   6    
HELIX  230 230 ILE T   54  MET T   59  1                                   6    
HELIX  231 231 ILE T   62  SER T   77  1                                  16    
HELIX  232 232 ALA T   83  GLY T  115  1                                  33    
HELIX  233 233 GLY T  115  GLN T  122  1                                   8    
HELIX  234 234 LEU T  125  THR T  155  1                                  31    
HELIX  235 235 THR T  155  CYS T  160  1                                   6    
HELIX  236 236 PHE W   12  VAL W   44  1                                  33    
HELIX  237 237 LEU W   49  ILE W   62  1                                  14    
HELIX  238 238 ILE W   62  SER W   77  1                                  16    
HELIX  239 239 ALA W   83  GLN W  122  1                                  40    
HELIX  240 240 LEU W  125  ALA W  136  1                                  12    
HELIX  241 241 ALA W  136  GLN W  156  1                                  21    
HELIX  242 242 PHE S   12  ARG S   46  1                                  35    
HELIX  243 243 LEU S   49  ILE S   62  1                                  14    
HELIX  244 244 ILE S   62  SER S   77  1                                  16    
HELIX  245 245 ALA S   83  GLN S  122  1                                  40    
HELIX  246 246 LEU S  125  THR S  155  1                                  31    
HELIX  247 247 PHE X   12  VAL X   44  1                                  33    
HELIX  248 248 LEU X   49  ILE X   62  1                                  14    
HELIX  249 249 ILE X   62  LEU X   78  1                                  17    
HELIX  250 250 ALA X   83  GLN X  122  1                                  40    
HELIX  251 251 LEU X  125  ILE X  134  1                                  10    
HELIX  252 252 ALA X  136  THR X  155  1                                  20    
HELIX  253 253 PHE Z   12  VAL Z   44  1                                  33    
HELIX  254 254 LEU Z   49  MET Z   59  1                                  11    
HELIX  255 255 ILE Z   62  SER Z   77  1                                  16    
HELIX  256 256 ALA Z   83  GLN Z  122  1                                  40    
HELIX  257 257 LEU Z  125  PHE Z  135  1                                  11    
HELIX  258 258 ALA Z  136  THR Z  155  1                                  20    
HELIX  259 259 PHE a   12  ARG a   46  1                                  35    
HELIX  260 260 LEU a   49  SER a   77  1                                  29    
HELIX  261 261 ALA a   83  GLN a  122  1                                  40    
HELIX  262 262 LEU a  125  THR a  155  1                                  31    
SHEET    1   A 2 PHE M  92  VAL M 101  0                                        
SHEET    2   A 2 VAL M 104  ILE M 113 -1  O  GLN M 108   N  ARG M  97           
SHEET    1   B 3 LEU N   7  ILE N  11  0                                        
SHEET    2   B 3 ILE N  64  ASN N  70  1  O  ALA N  65   N  LEU N   7           
SHEET    3   B 3 ALA N  90  ILE N  94  1  O  ALA N  90   N  LEU N  67           
SHEET    1   C 6 THR B  92  SER B  99  0                                        
SHEET    2   C 6 GLU B  51  THR B  56 -1  N  THR B  56   O  THR B  92           
SHEET    3   C 6 VAL B  62  ARG B  71 -1  O  ARG B  63   N  LEU B  55           
SHEET    4   C 6 ARG B  74  VAL B  79 -1  O  ILE B  76   N  GLU B  69           
SHEET    5   C 6 LEU B  38  GLU B  42 -1  N  VAL B  39   O  VAL B  77           
SHEET    6   C 6 THR B  30  ASN B  35 -1  N  ASN B  35   O  LEU B  38           
SHEET    1   D18 THR B  30  ASN B  35  0                                        
SHEET    2   D18 LEU B  38  GLU B  42 -1  O  LEU B  38   N  ASN B  35           
SHEET    3   D18 ARG B  74  VAL B  79 -1  O  VAL B  77   N  VAL B  39           
SHEET    4   D18 VAL B  62  ARG B  71 -1  N  GLU B  69   O  ILE B  76           
SHEET    5   D18 GLY A  25  SER A  31 -1  N  VAL A  30   O  ILE B  70           
SHEET    6   D18 VAL A  34  GLU A  38 -1  O  ILE A  36   N  SER A  29           
SHEET    7   D18 LYS A  67  VAL A  72 -1  O  ILE A  70   N  VAL A  35           
SHEET    8   D18 LEU A  56  ASP A  64 -1  N  ASP A  64   O  LYS A  67           
SHEET    9   D18 VAL F  31  ASN F  35 -1  O  VAL F  34   N  ILE A  63           
SHEET   10   D18 LEU F  38  LEU F  41 -1  O  LEU F  38   N  ASN F  35           
SHEET   11   D18 ARG F  74  VAL F  79 -1  O  ALA F  75   N  LEU F  41           
SHEET   12   D18 VAL F  62  ARG F  71 -1  N  ARG F  71   O  ARG F  74           
SHEET   13   D18 ALA E  26  SER E  31 -1  N  VAL E  30   O  ILE F  70           
SHEET   14   D18 VAL E  34  GLU E  38 -1  O  VAL E  34   N  SER E  31           
SHEET   15   D18 LYS E  67  VAL E  72 -1  O  ILE E  70   N  VAL E  35           
SHEET   16   D18 LEU E  56  ASP E  64 -1  N  ASP E  64   O  LYS E  67           
SHEET   17   D18 GLU E  47  VAL E  51 -1  N  GLU E  47   O  VAL E  60           
SHEET   18   D18 VAL E  85  PRO E  91 -1  O  LEU E  86   N  LYS E  50           
SHEET    1   E 9 VAL E  85  PRO E  91  0                                        
SHEET    2   E 9 GLU E  47  VAL E  51 -1  N  LYS E  50   O  LEU E  86           
SHEET    3   E 9 LEU E  56  ASP E  64 -1  O  VAL E  60   N  GLU E  47           
SHEET    4   E 9 LYS E  67  VAL E  72 -1  O  LYS E  67   N  ASP E  64           
SHEET    5   E 9 VAL E  34  GLU E  38 -1  N  VAL E  35   O  ILE E  70           
SHEET    6   E 9 ALA E  26  SER E  31 -1  N  SER E  31   O  VAL E  34           
SHEET    7   E 9 VAL F  62  ARG F  71 -1  O  ILE F  70   N  VAL E  30           
SHEET    8   E 9 GLU F  51  THR F  56 -1  N  LEU F  55   O  ARG F  63           
SHEET    9   E 9 THR F  92  SER F  99 -1  O  GLU F  94   N  ASN F  54           
SHEET    1   F13 THR F  92  SER F  99  0                                        
SHEET    2   F13 GLU F  51  THR F  56 -1  N  ASN F  54   O  GLU F  94           
SHEET    3   F13 VAL F  62  ARG F  71 -1  O  ARG F  63   N  LEU F  55           
SHEET    4   F13 ARG F  74  VAL F  79 -1  O  ARG F  74   N  ARG F  71           
SHEET    5   F13 LEU F  38  LEU F  41 -1  N  LEU F  41   O  ALA F  75           
SHEET    6   F13 VAL F  31  ASN F  35 -1  N  ASN F  35   O  LEU F  38           
SHEET    7   F13 LEU A  56  ASP A  64 -1  N  ILE A  63   O  VAL F  34           
SHEET    8   F13 GLU A  47  VAL A  51 -1  N  VAL A  51   O  LEU A  56           
SHEET    9   F13 PRO A  84  PRO A  91 -1  O  LEU A  86   N  LYS A  50           
SHEET   10   F13 GLY A  25  SER A  31 -1  N  GLY A  25   O  VAL A  85           
SHEET   11   F13 VAL B  62  ARG B  71 -1  O  ILE B  70   N  VAL A  30           
SHEET   12   F13 GLU B  51  THR B  56 -1  N  LEU B  55   O  ARG B  63           
SHEET   13   F13 THR B  92  SER B  99 -1  O  THR B  92   N  THR B  56           
SHEET    1   G 2 SER A  93  LEU A  96  0                                        
SHEET    2   G 2 HIS A 213  PRO A 216 -1  O  HIS A 213   N  LEU A  96           
SHEET    1   H 7 ILE A 104  TYR A 105  0                                        
SHEET    2   H 7 THR A 315  THR A 321  1  O  ALA A 319   N  TYR A 105           
SHEET    3   H 7 ALA A 277  GLU A 285  1  N  TYR A 280   O  VAL A 318           
SHEET    4   H 7 ASN A 349  ASP A 355  1  O  SER A 351   N  ILE A 279           
SHEET    5   H 7 THR A 407  VAL A 416  1  O  SER A 411   N  MET A 352           
SHEET    6   H 7 GLY A 396  VAL A 399 -1  N  ALA A 398   O  GLY A 408           
SHEET    7   H 7 GLU A 225  LEU A 227 -1  N  GLU A 225   O  VAL A 399           
SHEET    1   I 6 ILE A 104  TYR A 105  0                                        
SHEET    2   I 6 THR A 315  THR A 321  1  O  ALA A 319   N  TYR A 105           
SHEET    3   I 6 ALA A 277  GLU A 285  1  N  TYR A 280   O  VAL A 318           
SHEET    4   I 6 ASN A 349  ASP A 355  1  O  SER A 351   N  ILE A 279           
SHEET    5   I 6 THR A 407  VAL A 416  1  O  SER A 411   N  MET A 352           
SHEET    6   I 6 CYS A 253  PRO A 255  1  N  ILE A 254   O  VAL A 416           
SHEET    1   J 4 HIS A 170  LEU A 173  0                                        
SHEET    2   J 4 ILE A 157  VAL A 161 -1  N  VAL A 161   O  HIS A 170           
SHEET    3   J 4 LYS A 138  PRO A 143 -1  N  THR A 142   O  SER A 160           
SHEET    4   J 4 GLY A 189  THR A 192 -1  O  GLY A 189   N  PHE A 141           
SHEET    1   K 4 HIS A 151  ILE A 152  0                                        
SHEET    2   K 4 GLY A 180  ILE A 185 -1  O  GLY A 180   N  ILE A 152           
SHEET    3   K 4 LEU A 198  GLU A 201 -1  O  GLU A 201   N  THR A 181           
SHEET    4   K 4 LYS A 205  PHE A 209 -1  O  PHE A 209   N  LEU A 198           
SHEET    1   L 2 VAL A 437  PHE A 438  0                                        
SHEET    2   L 2 TYR A 460  SER A 461 -1  O  TYR A 460   N  PHE A 438           
SHEET    1   M 2 ARG B 101  VAL B 104  0                                        
SHEET    2   M 2 ASP B 130  ASP B 133 -1  O  ASP B 130   N  VAL B 104           
SHEET    1   N 6 ILE B 112  PHE B 113  0                                        
SHEET    2   N 6 THR B 238  LEU B 244  1  O  LEU B 242   N  PHE B 113           
SHEET    3   N 6 PHE B 208  VAL B 217  1  N  PHE B 212   O  SER B 239           
SHEET    4   N 6 HIS B 273  THR B 279  1  O  THR B 279   N  ALA B 213           
SHEET    5   N 6 SER B 328  MET B 337  1  O  THR B 330   N  VAL B 274           
SHEET    6   N 6 GLY B 320  ARG B 321 -1  N  GLY B 320   O  ILE B 329           
SHEET    1   O 8 ILE B 112  PHE B 113  0                                        
SHEET    2   O 8 THR B 238  LEU B 244  1  O  LEU B 242   N  PHE B 113           
SHEET    3   O 8 PHE B 208  VAL B 217  1  N  PHE B 212   O  SER B 239           
SHEET    4   O 8 HIS B 273  THR B 279  1  O  THR B 279   N  ALA B 213           
SHEET    5   O 8 SER B 328  MET B 337  1  O  THR B 330   N  VAL B 274           
SHEET    6   O 8 ILE B 172  ALA B 175  1  N  SER B 174   O  MET B 337           
SHEET    7   O 8 GLY B 356  PHE B 359  1  O  ILE B 358   N  PHE B 173           
SHEET    8   O 8 LEU B 379  SER B 380 -1  O  LEU B 379   N  GLN B 357           
SHEET    1   P 2 MET B 150  ILE B 151  0                                        
SHEET    2   P 2 ILE B 164  ALA B 165 -1  O  ILE B 164   N  ILE B 151           
SHEET    1   Q 7 THR D  30  ASN D  35  0                                        
SHEET    2   Q 7 LEU D  38  GLU D  42 -1  O  LEU D  38   N  ASN D  35           
SHEET    3   Q 7 ARG D  74  VAL D  79 -1  O  VAL D  77   N  VAL D  39           
SHEET    4   Q 7 VAL D  62  ARG D  71 -1  N  LEU D  68   O  ILE D  76           
SHEET    5   Q 7 GLY C  25  SER C  31 -1  N  VAL C  30   O  ILE D  70           
SHEET    6   Q 7 GLU D  51  THR D  56  0                                        
SHEET    7   Q 7 THR D  92  SER D  99 -1  O  THR D  92   N  THR D  56           
SHEET    1   R12 THR D  30  ASN D  35  0                                        
SHEET    2   R12 LEU D  38  GLU D  42 -1  O  LEU D  38   N  ASN D  35           
SHEET    3   R12 ARG D  74  VAL D  79 -1  O  VAL D  77   N  VAL D  39           
SHEET    4   R12 VAL D  62  ARG D  71 -1  N  LEU D  68   O  ILE D  76           
SHEET    5   R12 PRO C  84  PRO C  91  0                                        
SHEET    6   R12 GLU C  47  VAL C  51 -1  N  LYS C  50   O  LEU C  86           
SHEET    7   R12 LEU C  56  ASP C  64 -1  O  LEU C  56   N  VAL C  51           
SHEET    8   R12 LYS C  67  VAL C  72 -1  O  LYS C  67   N  ASP C  64           
SHEET    9   R12 VAL C  34  GLU C  38 -1  N  VAL C  35   O  ILE C  70           
SHEET   10   R12 GLY C  25  SER C  31 -1  N  SER C  29   O  ILE C  36           
SHEET   11   R12 GLU D  51  THR D  56  0                                        
SHEET   12   R12 THR D  92  SER D  99 -1  O  THR D  92   N  THR D  56           
SHEET    1   S 2 SER C  93  LEU C  96  0                                        
SHEET    2   S 2 HIS C 213  PRO C 216 -1  O  HIS C 213   N  LEU C  96           
SHEET    1   T 7 ILE C 104  TYR C 105  0                                        
SHEET    2   T 7 THR C 315  THR C 321  1  O  LEU C 317   N  TYR C 105           
SHEET    3   T 7 ALA C 277  GLU C 285  1  N  TYR C 280   O  VAL C 318           
SHEET    4   T 7 ASN C 349  ASP C 355  1  O  SER C 351   N  ILE C 279           
SHEET    5   T 7 THR C 407  VAL C 416  1  O  SER C 411   N  MET C 352           
SHEET    6   T 7 GLY C 396  VAL C 399 -1  N  ALA C 398   O  GLY C 408           
SHEET    7   T 7 GLU C 225  LEU C 227 -1  N  LEU C 227   O  LYS C 397           
SHEET    1   U 8 ILE C 104  TYR C 105  0                                        
SHEET    2   U 8 THR C 315  THR C 321  1  O  LEU C 317   N  TYR C 105           
SHEET    3   U 8 ALA C 277  GLU C 285  1  N  TYR C 280   O  VAL C 318           
SHEET    4   U 8 ASN C 349  ASP C 355  1  O  SER C 351   N  ILE C 279           
SHEET    5   U 8 THR C 407  VAL C 416  1  O  SER C 411   N  MET C 352           
SHEET    6   U 8 THR C 251  PRO C 255  1  N  THR C 252   O  ALA C 414           
SHEET    7   U 8 VAL C 437  PHE C 438  1  O  VAL C 437   N  CYS C 253           
SHEET    8   U 8 TYR C 460  SER C 461 -1  O  TYR C 460   N  PHE C 438           
SHEET    1   V 4 HIS C 170  LEU C 173  0                                        
SHEET    2   V 4 ILE C 157  VAL C 161 -1  N  TYR C 158   O  ILE C 172           
SHEET    3   V 4 LYS C 138  PRO C 143 -1  N  THR C 142   O  SER C 160           
SHEET    4   V 4 GLY C 189  THR C 192 -1  O  GLY C 189   N  PHE C 141           
SHEET    1   W 4 HIS C 151  ILE C 152  0                                        
SHEET    2   W 4 GLY C 180  ILE C 185 -1  O  GLY C 180   N  ILE C 152           
SHEET    3   W 4 LEU C 198  GLU C 201 -1  O  GLU C 201   N  THR C 181           
SHEET    4   W 4 LYS C 205  PHE C 209 -1  O  PHE C 209   N  LEU C 198           
SHEET    1   X 2 ARG D 101  VAL D 104  0                                        
SHEET    2   X 2 ASP D 130  ASP D 133 -1  O  LEU D 132   N  ILE D 102           
SHEET    1   Y 6 ARG D 111  PHE D 113  0                                        
SHEET    2   Y 6 THR D 238  PHE D 241  1  O  LEU D 240   N  PHE D 113           
SHEET    3   Y 6 PHE D 208  ALA D 213  1  N  PHE D 212   O  PHE D 241           
SHEET    4   Y 6 HIS D 273  THR D 279  1  O  ILE D 277   N  VAL D 211           
SHEET    5   Y 6 SER D 328  MET D 337  1  O  THR D 330   N  VAL D 274           
SHEET    6   Y 6 GLY D 320  ARG D 321 -1  N  GLY D 320   O  ILE D 329           
SHEET    1   Z 8 ARG D 111  PHE D 113  0                                        
SHEET    2   Z 8 THR D 238  PHE D 241  1  O  LEU D 240   N  PHE D 113           
SHEET    3   Z 8 PHE D 208  ALA D 213  1  N  PHE D 212   O  PHE D 241           
SHEET    4   Z 8 HIS D 273  THR D 279  1  O  ILE D 277   N  VAL D 211           
SHEET    5   Z 8 SER D 328  MET D 337  1  O  THR D 330   N  VAL D 274           
SHEET    6   Z 8 ILE D 172  ALA D 175  1  N  ILE D 172   O  LEU D 335           
SHEET    7   Z 8 GLN D 357  VAL D 360  1  O  ILE D 358   N  PHE D 173           
SHEET    8   Z 8 ILE D 373  LEU D 379 -1  O  ASN D 374   N  PHE D 359           
SHEET    1  AA 2 MET D 150  ILE D 151  0                                        
SHEET    2  AA 2 ILE D 164  ALA D 165 -1  O  ILE D 164   N  ILE D 151           
SHEET    1  AB 2 SER E  93  LEU E  96  0                                        
SHEET    2  AB 2 HIS E 213  PRO E 216 -1  O  HIS E 213   N  LEU E  96           
SHEET    1  AC 7 ILE E 104  TYR E 105  0                                        
SHEET    2  AC 7 THR E 315  VAL E 318  1  O  LEU E 317   N  TYR E 105           
SHEET    3  AC 7 ALA E 277  GLY E 282  1  N  TYR E 280   O  VAL E 318           
SHEET    4  AC 7 ASN E 349  ASP E 355  1  O  ASN E 349   N  ALA E 277           
SHEET    5  AC 7 THR E 407  ALA E 415  1  O  SER E 411   N  MET E 352           
SHEET    6  AC 7 GLY E 396  VAL E 399 -1  N  ALA E 398   O  GLY E 408           
SHEET    7  AC 7 GLU E 225  LYS E 226 -1  N  GLU E 225   O  VAL E 399           
SHEET    1  AD 8 ILE E 104  TYR E 105  0                                        
SHEET    2  AD 8 THR E 315  VAL E 318  1  O  LEU E 317   N  TYR E 105           
SHEET    3  AD 8 ALA E 277  GLY E 282  1  N  TYR E 280   O  VAL E 318           
SHEET    4  AD 8 ASN E 349  ASP E 355  1  O  ASN E 349   N  ALA E 277           
SHEET    5  AD 8 THR E 407  ALA E 415  1  O  SER E 411   N  MET E 352           
SHEET    6  AD 8 THR E 251  ILE E 254  1  N  THR E 252   O  ALA E 414           
SHEET    7  AD 8 VAL E 437  PHE E 438  1  O  VAL E 437   N  CYS E 253           
SHEET    8  AD 8 TYR E 460  SER E 461 -1  O  TYR E 460   N  PHE E 438           
SHEET    1  AE 2 LYS E 138  PHE E 141  0                                        
SHEET    2  AE 2 GLY E 189  THR E 192 -1  O  TYR E 191   N  TRP E 139           
SHEET    1  AF 4 HIS E 151  SER E 153  0                                        
SHEET    2  AF 4 ARG E 179  ILE E 185 -1  O  GLY E 180   N  ILE E 152           
SHEET    3  AF 4 LYS E 196  GLU E 201 -1  O  GLU E 201   N  THR E 181           
SHEET    4  AF 4 LYS E 205  THR E 210 -1  O  PHE E 209   N  LEU E 198           
SHEET    1  AG 2 ILE E 157  VAL E 161  0                                        
SHEET    2  AG 2 HIS E 170  LEU E 173 -1  O  HIS E 170   N  VAL E 161           
SHEET    1  AH 2 TYR E 231  PRO E 232  0                                        
SHEET    2  AH 2 VAL E 247  GLN E 248 -1  O  GLN E 248   N  TYR E 231           
SHEET    1  AI 2 ARG F 101  VAL F 104  0                                        
SHEET    2  AI 2 ASP F 130  ASP F 133 -1  O  LEU F 132   N  ILE F 102           
SHEET    1  AJ 6 ILE F 112  PHE F 113  0                                        
SHEET    2  AJ 6 THR F 238  LEU F 242  1  O  LEU F 240   N  PHE F 113           
SHEET    3  AJ 6 PHE F 208  ALA F 214  1  N  PHE F 212   O  SER F 239           
SHEET    4  AJ 6 HIS F 273  THR F 279  1  O  ILE F 277   N  ALA F 213           
SHEET    5  AJ 6 GLY F 327  MET F 337  1  O  ILE F 334   N  LEU F 278           
SHEET    6  AJ 6 GLY F 320  VAL F 322 -1  N  VAL F 322   O  GLY F 327           
SHEET    1  AK 7 ILE F 112  PHE F 113  0                                        
SHEET    2  AK 7 THR F 238  LEU F 242  1  O  LEU F 240   N  PHE F 113           
SHEET    3  AK 7 PHE F 208  ALA F 214  1  N  PHE F 212   O  SER F 239           
SHEET    4  AK 7 HIS F 273  THR F 279  1  O  ILE F 277   N  ALA F 213           
SHEET    5  AK 7 GLY F 327  MET F 337  1  O  ILE F 334   N  LEU F 278           
SHEET    6  AK 7 ILE F 172  ALA F 175  1  N  ILE F 172   O  LEU F 335           
SHEET    7  AK 7 ILE F 358  PHE F 359  1  O  ILE F 358   N  PHE F 173           
SHEET    1  AL 4 GLU K 171  TYR K 178  0                                        
SHEET    2  AL 4 LYS K 136  ALA K 141  1  N  VAL K 139   O  VAL K 173           
SHEET    3  AL 4 GLY K 187  SER K 191 -1  O  VAL K 189   N  LYS K 140           
SHEET    4  AL 4 GLU K 198  THR K 202 -1  O  ILE K 199   N  VAL K 190           
SHEET    1  AM 3 ALA b  15  ILE b  21  0                                        
SHEET    2  AM 3 LEU b 335  ILE b 341 -1  O  ALA b 337   N  PHE b  19           
SHEET    3  AM 3 VAL b  39  LEU b  44 -1  N  ARG b  42   O  GLU b 338           
SHEET    1  AN 3 ASN b 185  ILE b 191  0                                        
SHEET    2  AN 3 ALA b 235  HIS b 241 -1  O  ILE b 237   N  GLY b 189           
SHEET    3  AN 3 THR b 215  ILE b 218 -1  N  GLU b 217   O  PHE b 236           
SHEET    1  AO 4 PHE O  44  ASP O  47  0                                        
SHEET    2  AO 4 PHE O 325  VAL O 332 -1  O  ALA O 331   N  PHE O  44           
SHEET    3  AO 4 ASP O  10  PRO O  17 -1  N  ASP O  10   O  VAL O 332           
SHEET    4  AO 4 MET O 387  ILE O 390 -1  O  ILE O 390   N  PHE O  11           
SHEET    1  AP 4 SER O 223  GLU O 227  0                                        
SHEET    2  AP 4 TYR O 231  PHE O 239 -1  O  LEU O 233   N  ALA O 226           
SHEET    3  AP 4 LEU O 191  PRO O 199 -1  N  VAL O 196   O  PHE O 234           
SHEET    4  AP 4 ILE O 256  ARG O 258 -1  O  ILE O 256   N  ALA O 197           
SHEET    1  AQ 4 GLU G 171  ILE G 174  0                                        
SHEET    2  AQ 4 LYS G 136  LYS G 140  1  N  VAL G 139   O  VAL G 173           
SHEET    3  AQ 4 GLY G 187  SER G 191 -1  O  VAL G 189   N  LYS G 140           
SHEET    4  AQ 4 GLU G 198  THR G 202 -1  O  ILE G 199   N  VAL G 190           
SHEET    1  AR 4 GLU I 171  ILE I 174  0                                        
SHEET    2  AR 4 LYS I 136  LYS I 140  1  N  VAL I 139   O  VAL I 173           
SHEET    3  AR 4 GLY I 187  ASN I 192 -1  O  SER I 191   N  ILE I 138           
SHEET    4  AR 4 GLU I 198  THR I 202 -1  O  ILE I 199   N  VAL I 190           
CISPEP   1 PHE N   88    PRO N   89          0        -4.22                     
CISPEP   2 ASP A  355    SER A  356          0         4.41                     
CISPEP   3 PHE A  451    PRO A  452          0        -4.91                     
CISPEP   4 THR B  279    ASP B  280          0         3.95                     
CISPEP   5 TYR B  370    PRO B  371          0       -15.63                     
CISPEP   6 ASP C  355    SER C  356          0         1.53                     
CISPEP   7 PHE C  451    PRO C  452          0        -2.80                     
CISPEP   8 THR D  279    ASP D  280          0         9.29                     
CISPEP   9 TYR D  370    PRO D  371          0       -10.16                     
CISPEP  10 ASP E  355    SER E  356          0        -3.35                     
CISPEP  11 PHE E  451    PRO E  452          0        -9.69                     
CISPEP  12 THR F  279    ASP F  280          0        -9.74                     
CISPEP  13 TYR F  370    PRO F  371          0        -8.41                     
CISPEP  14 THR Q  156    PRO Q  157          0        -4.72                     
CISPEP  15 SER b  271    GLN b  272          0        -2.09                     
CISPEP  16 LEU O  321    PRO O  322          0         3.55                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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