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Database: PDB
Entry: 3NAZ
LinkDB: 3NAZ
Original site: 3NAZ 
HEADER    TRANSFERASE                             02-JUN-10   3NAZ              
TITLE     BASAL STATE FORM OF YEAST GLYCOGEN SYNTHASE                           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: GLYCOGEN [STARCH] SYNTHASE ISOFORM 2;                      
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 EC: 2.4.1.11;                                                        
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MUTATION: YES;                                                       
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: PEPTIDE;                                                   
COMPND   9 CHAIN: E, F;                                                         
COMPND  10 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BREWER'S YEAST,LAGER BEER YEAST,YEAST;              
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 GENE: GSY2, L8479.8, YLR258W;                                        
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21-DE3;                                  
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET28A;                                   
SOURCE  11 MOL_ID: 2;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  13 ORGANISM_COMMON: BREWER'S YEAST,LAGER BEER YEAST,YEAST;              
SOURCE  14 ORGANISM_TAXID: 4932;                                                
SOURCE  15 GENE: GSY2, L8479.8, YLR258W;                                        
SOURCE  16 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  17 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  18 EXPRESSION_SYSTEM_STRAIN: BL21-DE3;                                  
SOURCE  19 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  20 EXPRESSION_SYSTEM_PLASMID: PET28A                                    
KEYWDS    GLYCOGEN SYNTHASE, GLUCOSE-6-PHOSPHATE, YEAST, ALLOSTERIC ACTIVATION, 
KEYWDS   2 TRANSFERASE                                                          
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    S.BASKARAN,T.D.HURLEY                                                 
REVDAT   3   20-OCT-10 3NAZ    1       JRNL                                     
REVDAT   2   13-OCT-10 3NAZ    1       JRNL                                     
REVDAT   1   06-OCT-10 3NAZ    0                                                
JRNL        AUTH   S.BASKARAN,P.J.ROACH,A.A.DEPAOLI-ROACH,T.D.HURLEY            
JRNL        TITL   STRUCTURAL BASIS FOR GLUCOSE-6-PHOSPHATE ACTIVATION OF       
JRNL        TITL 2 GLYCOGEN SYNTHASE.                                           
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 107 17563 2010              
JRNL        REFN                   ISSN 0027-8424                               
JRNL        PMID   20876143                                                     
JRNL        DOI    10.1073/PNAS.1006340107                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE)                               
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.03                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 0.070                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 94.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 70557                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.205                           
REMARK   3   R VALUE            (WORKING SET) : 0.203                           
REMARK   3   FREE R VALUE                     : 0.254                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.050                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3566                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 48.0390 -  8.7480    0.99     2851   165  0.1810 0.2280        
REMARK   3     2  8.7480 -  6.9500    1.00     2877   130  0.1600 0.2250        
REMARK   3     3  6.9500 -  6.0740    1.00     2828   156  0.1910 0.2410        
REMARK   3     4  6.0740 -  5.5190    0.99     2830   142  0.1970 0.2950        
REMARK   3     5  5.5190 -  5.1240    0.99     2810   157  0.1780 0.2300        
REMARK   3     6  5.1240 -  4.8220    1.00     2828   149  0.1620 0.2150        
REMARK   3     7  4.8220 -  4.5810    1.00     2813   155  0.1610 0.1870        
REMARK   3     8  4.5810 -  4.3820    1.00     2793   154  0.1720 0.2520        
REMARK   3     9  4.3820 -  4.2130    0.99     2826   161  0.1800 0.2550        
REMARK   3    10  4.2130 -  4.0680    0.99     2784   161  0.1790 0.2140        
REMARK   3    11  4.0680 -  3.9410    0.99     2771   166  0.1880 0.2270        
REMARK   3    12  3.9410 -  3.8280    0.98     2770   162  0.1980 0.2620        
REMARK   3    13  3.8280 -  3.7270    0.98     2727   152  0.2080 0.2520        
REMARK   3    14  3.7270 -  3.6360    0.98     2745   141  0.2060 0.2380        
REMARK   3    15  3.6360 -  3.5540    0.96     2711   139  0.2140 0.2470        
REMARK   3    16  3.5540 -  3.4780    0.96     2736   139  0.2270 0.2720        
REMARK   3    17  3.4780 -  3.4090    0.95     2629   160  0.2290 0.2770        
REMARK   3    18  3.4090 -  3.3440    0.94     2649   138  0.2350 0.2870        
REMARK   3    19  3.3440 -  3.2850    0.92     2643   128  0.2480 0.3050        
REMARK   3    20  3.2850 -  3.2290    0.90     2519   123  0.2610 0.3110        
REMARK   3    21  3.2290 -  3.1770    0.90     2584   114  0.2750 0.3160        
REMARK   3    22  3.1770 -  3.1280    0.88     2468   120  0.2740 0.3420        
REMARK   3    23  3.1280 -  3.0820    0.85     2429   125  0.2820 0.3150        
REMARK   3    24  3.0820 -  3.0390    0.83     2329   115  0.2980 0.3490        
REMARK   3    25  3.0390 -  3.0000    0.72     2041   114  0.3220 0.3840        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : 0.32                                          
REMARK   3   B_SOL              : 27.80                                         
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 2.440            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : NULL             
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 65.40                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 64.47                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 3.23400                                              
REMARK   3    B22 (A**2) : 6.73700                                              
REMARK   3    B33 (A**2) : -9.97100                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 2.48600                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.008          20292                                  
REMARK   3   ANGLE     :  1.068          27473                                  
REMARK   3   CHIRALITY :  0.076           2980                                  
REMARK   3   PLANARITY :  0.004           3543                                  
REMARK   3   DIHEDRAL  : 19.122           7308                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 3NAZ COMPLIES WITH FORMAT V. 3.20, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 03-JUN-10.                  
REMARK 100 THE RCSB ID CODE IS RCSB059602.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 30-OCT-08                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 8.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 23-ID-B                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.99                               
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 300 MM CCD               
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 73853                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.200                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6                               
REMARK 200  DATA REDUNDANCY                : 3.700                              
REMARK 200  R MERGE                    (I) : 0.08200                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 13.5000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MIR                          
REMARK 200 SOFTWARE USED: SOLVE, PHENIX                                         
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 57.08                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.87                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M TRIS-HCL PH 8.5, 20% PEG 3400,     
REMARK 280  0.2 M LITHIUM SULFATE, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE   
REMARK 280  293K                                                                
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       83.07700            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 11520 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 97010 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -256.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -19                                                      
REMARK 465     GLY A   -18                                                      
REMARK 465     SER A   -17                                                      
REMARK 465     SER A   -16                                                      
REMARK 465     HIS A   -15                                                      
REMARK 465     HIS A   -14                                                      
REMARK 465     HIS A   -13                                                      
REMARK 465     HIS A   -12                                                      
REMARK 465     HIS A   -11                                                      
REMARK 465     HIS A   -10                                                      
REMARK 465     SER A    -9                                                      
REMARK 465     SER A    -8                                                      
REMARK 465     GLY A    -7                                                      
REMARK 465     LEU A    -6                                                      
REMARK 465     VAL A    -5                                                      
REMARK 465     PRO A    -4                                                      
REMARK 465     ARG A    -3                                                      
REMARK 465     GLY A    -2                                                      
REMARK 465     SER A    -1                                                      
REMARK 465     HIS A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     SER A   206                                                      
REMARK 465     PHE A   207                                                      
REMARK 465     ALA A   278                                                      
REMARK 465     PHE A   279                                                      
REMARK 465     HIS A   280                                                      
REMARK 465     GLU A   281                                                      
REMARK 465     PHE A   282                                                      
REMARK 465     GLN A   283                                                      
REMARK 465     ASN A   284                                                      
REMARK 465     HIS A   402                                                      
REMARK 465     ASN A   403                                                      
REMARK 465     GLY A   404                                                      
REMARK 465     LEU A   405                                                      
REMARK 465     THR A   406                                                      
REMARK 465     THR A   407                                                      
REMARK 465     GLU A   408                                                      
REMARK 465     LEU A   409                                                      
REMARK 465     PRO A   410                                                      
REMARK 465     THR A   411                                                      
REMARK 465     ASP A   412                                                      
REMARK 465     LEU A   413                                                      
REMARK 465     GLY A   414                                                      
REMARK 465     ILE A   541                                                      
REMARK 465     GLU A   542                                                      
REMARK 465     THR A   543                                                      
REMARK 465     ASN A   544                                                      
REMARK 465     GLN A   545                                                      
REMARK 465     GLY A   640                                                      
REMARK 465     GLY A   641                                                      
REMARK 465     LYS A   642                                                      
REMARK 465     LYS A   643                                                      
REMARK 465     LEU A   644                                                      
REMARK 465     LYS A   645                                                      
REMARK 465     VAL A   646                                                      
REMARK 465     ALA A   647                                                      
REMARK 465     ARG A   648                                                      
REMARK 465     PRO A   649                                                      
REMARK 465     LEU A   650                                                      
REMARK 465     SER A   651                                                      
REMARK 465     VAL A   652                                                      
REMARK 465     PRO A   653                                                      
REMARK 465     GLY A   654                                                      
REMARK 465     SER A   655                                                      
REMARK 465     PRO A   656                                                      
REMARK 465     ARG A   657                                                      
REMARK 465     ASP A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     ARG A   660                                                      
REMARK 465     SER A   661                                                      
REMARK 465     ASN A   662                                                      
REMARK 465     SER A   663                                                      
REMARK 465     THR A   664                                                      
REMARK 465     VAL A   665                                                      
REMARK 465     TYR A   666                                                      
REMARK 465     MET A   667                                                      
REMARK 465     THR A   668                                                      
REMARK 465     PRO A   669                                                      
REMARK 465     GLY A   670                                                      
REMARK 465     ASP A   671                                                      
REMARK 465     LEU A   672                                                      
REMARK 465     GLY A   673                                                      
REMARK 465     THR A   674                                                      
REMARK 465     LEU A   675                                                      
REMARK 465     GLN A   676                                                      
REMARK 465     GLU A   677                                                      
REMARK 465     VAL A   678                                                      
REMARK 465     ASN A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     ALA A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     ASP A   683                                                      
REMARK 465     TYR A   684                                                      
REMARK 465     PHE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     GLY A   688                                                      
REMARK 465     VAL A   689                                                      
REMARK 465     ASN A   690                                                      
REMARK 465     PRO A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     ALA A   693                                                      
REMARK 465     ASP A   694                                                      
REMARK 465     ASP A   695                                                      
REMARK 465     ASP A   696                                                      
REMARK 465     ASP A   697                                                      
REMARK 465     ASP A   698                                                      
REMARK 465     GLY A   699                                                      
REMARK 465     PRO A   700                                                      
REMARK 465     TYR A   701                                                      
REMARK 465     ALA A   702                                                      
REMARK 465     ASP A   703                                                      
REMARK 465     ASP A   704                                                      
REMARK 465     SER A   705                                                      
REMARK 465     MET B   -19                                                      
REMARK 465     GLY B   -18                                                      
REMARK 465     SER B   -17                                                      
REMARK 465     SER B   -16                                                      
REMARK 465     HIS B   -15                                                      
REMARK 465     HIS B   -14                                                      
REMARK 465     HIS B   -13                                                      
REMARK 465     HIS B   -12                                                      
REMARK 465     HIS B   -11                                                      
REMARK 465     HIS B   -10                                                      
REMARK 465     SER B    -9                                                      
REMARK 465     SER B    -8                                                      
REMARK 465     GLY B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     VAL B    -5                                                      
REMARK 465     PRO B    -4                                                      
REMARK 465     ARG B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     SER B    -1                                                      
REMARK 465     HIS B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B   206                                                      
REMARK 465     PHE B   207                                                      
REMARK 465     ALA B   278                                                      
REMARK 465     PHE B   279                                                      
REMARK 465     HIS B   280                                                      
REMARK 465     GLU B   281                                                      
REMARK 465     PHE B   282                                                      
REMARK 465     GLN B   283                                                      
REMARK 465     ASN B   284                                                      
REMARK 465     HIS B   402                                                      
REMARK 465     ASN B   403                                                      
REMARK 465     GLY B   404                                                      
REMARK 465     LEU B   405                                                      
REMARK 465     THR B   406                                                      
REMARK 465     THR B   407                                                      
REMARK 465     GLU B   408                                                      
REMARK 465     LEU B   409                                                      
REMARK 465     PRO B   410                                                      
REMARK 465     THR B   411                                                      
REMARK 465     ASP B   412                                                      
REMARK 465     LEU B   413                                                      
REMARK 465     GLY B   414                                                      
REMARK 465     ILE B   541                                                      
REMARK 465     GLU B   542                                                      
REMARK 465     THR B   543                                                      
REMARK 465     ASN B   544                                                      
REMARK 465     GLN B   545                                                      
REMARK 465     GLY B   640                                                      
REMARK 465     GLY B   641                                                      
REMARK 465     LYS B   642                                                      
REMARK 465     LYS B   643                                                      
REMARK 465     LEU B   644                                                      
REMARK 465     LYS B   645                                                      
REMARK 465     VAL B   646                                                      
REMARK 465     ALA B   647                                                      
REMARK 465     ARG B   648                                                      
REMARK 465     PRO B   649                                                      
REMARK 465     LEU B   650                                                      
REMARK 465     SER B   651                                                      
REMARK 465     VAL B   652                                                      
REMARK 465     PRO B   653                                                      
REMARK 465     GLY B   654                                                      
REMARK 465     SER B   655                                                      
REMARK 465     PRO B   656                                                      
REMARK 465     ARG B   657                                                      
REMARK 465     ASP B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     ARG B   660                                                      
REMARK 465     SER B   661                                                      
REMARK 465     ASN B   662                                                      
REMARK 465     SER B   663                                                      
REMARK 465     THR B   664                                                      
REMARK 465     VAL B   665                                                      
REMARK 465     TYR B   666                                                      
REMARK 465     MET B   667                                                      
REMARK 465     THR B   668                                                      
REMARK 465     PRO B   669                                                      
REMARK 465     GLY B   670                                                      
REMARK 465     ASP B   671                                                      
REMARK 465     LEU B   672                                                      
REMARK 465     GLY B   673                                                      
REMARK 465     THR B   674                                                      
REMARK 465     LEU B   675                                                      
REMARK 465     GLN B   676                                                      
REMARK 465     GLU B   677                                                      
REMARK 465     VAL B   678                                                      
REMARK 465     ASN B   679                                                      
REMARK 465     ASN B   680                                                      
REMARK 465     ALA B   681                                                      
REMARK 465     ASP B   682                                                      
REMARK 465     ASP B   683                                                      
REMARK 465     TYR B   684                                                      
REMARK 465     PHE B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     LEU B   687                                                      
REMARK 465     GLY B   688                                                      
REMARK 465     VAL B   689                                                      
REMARK 465     ASN B   690                                                      
REMARK 465     PRO B   691                                                      
REMARK 465     ALA B   692                                                      
REMARK 465     ALA B   693                                                      
REMARK 465     ASP B   694                                                      
REMARK 465     ASP B   695                                                      
REMARK 465     ASP B   696                                                      
REMARK 465     ASP B   697                                                      
REMARK 465     ASP B   698                                                      
REMARK 465     GLY B   699                                                      
REMARK 465     PRO B   700                                                      
REMARK 465     TYR B   701                                                      
REMARK 465     ALA B   702                                                      
REMARK 465     ASP B   703                                                      
REMARK 465     ASP B   704                                                      
REMARK 465     SER B   705                                                      
REMARK 465     MET C   -19                                                      
REMARK 465     GLY C   -18                                                      
REMARK 465     SER C   -17                                                      
REMARK 465     SER C   -16                                                      
REMARK 465     HIS C   -15                                                      
REMARK 465     HIS C   -14                                                      
REMARK 465     HIS C   -13                                                      
REMARK 465     HIS C   -12                                                      
REMARK 465     HIS C   -11                                                      
REMARK 465     HIS C   -10                                                      
REMARK 465     SER C    -9                                                      
REMARK 465     SER C    -8                                                      
REMARK 465     GLY C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     VAL C    -5                                                      
REMARK 465     PRO C    -4                                                      
REMARK 465     ARG C    -3                                                      
REMARK 465     GLY C    -2                                                      
REMARK 465     SER C    -1                                                      
REMARK 465     HIS C     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C   206                                                      
REMARK 465     PHE C   207                                                      
REMARK 465     ALA C   278                                                      
REMARK 465     PHE C   279                                                      
REMARK 465     HIS C   280                                                      
REMARK 465     GLU C   281                                                      
REMARK 465     PHE C   282                                                      
REMARK 465     GLN C   283                                                      
REMARK 465     HIS C   402                                                      
REMARK 465     ASN C   403                                                      
REMARK 465     GLY C   404                                                      
REMARK 465     LEU C   405                                                      
REMARK 465     THR C   406                                                      
REMARK 465     THR C   407                                                      
REMARK 465     GLU C   408                                                      
REMARK 465     LEU C   409                                                      
REMARK 465     PRO C   410                                                      
REMARK 465     THR C   411                                                      
REMARK 465     ASP C   412                                                      
REMARK 465     LEU C   413                                                      
REMARK 465     ILE C   541                                                      
REMARK 465     GLU C   542                                                      
REMARK 465     THR C   543                                                      
REMARK 465     ASN C   544                                                      
REMARK 465     GLN C   545                                                      
REMARK 465     GLY C   640                                                      
REMARK 465     GLY C   641                                                      
REMARK 465     LYS C   642                                                      
REMARK 465     LYS C   643                                                      
REMARK 465     LEU C   644                                                      
REMARK 465     LYS C   645                                                      
REMARK 465     VAL C   646                                                      
REMARK 465     ALA C   647                                                      
REMARK 465     ARG C   648                                                      
REMARK 465     PRO C   649                                                      
REMARK 465     LEU C   650                                                      
REMARK 465     SER C   651                                                      
REMARK 465     VAL C   652                                                      
REMARK 465     PRO C   653                                                      
REMARK 465     GLY C   654                                                      
REMARK 465     SER C   655                                                      
REMARK 465     PRO C   656                                                      
REMARK 465     ARG C   657                                                      
REMARK 465     ASP C   658                                                      
REMARK 465     LEU C   659                                                      
REMARK 465     ARG C   660                                                      
REMARK 465     SER C   661                                                      
REMARK 465     ASN C   662                                                      
REMARK 465     SER C   663                                                      
REMARK 465     THR C   664                                                      
REMARK 465     VAL C   665                                                      
REMARK 465     TYR C   666                                                      
REMARK 465     MET C   667                                                      
REMARK 465     THR C   668                                                      
REMARK 465     PRO C   669                                                      
REMARK 465     GLY C   670                                                      
REMARK 465     ASP C   671                                                      
REMARK 465     LEU C   672                                                      
REMARK 465     GLY C   673                                                      
REMARK 465     THR C   674                                                      
REMARK 465     LEU C   675                                                      
REMARK 465     GLN C   676                                                      
REMARK 465     GLU C   677                                                      
REMARK 465     VAL C   678                                                      
REMARK 465     ASN C   679                                                      
REMARK 465     ASN C   680                                                      
REMARK 465     ALA C   681                                                      
REMARK 465     ASP C   682                                                      
REMARK 465     ASP C   683                                                      
REMARK 465     TYR C   684                                                      
REMARK 465     PHE C   685                                                      
REMARK 465     SER C   686                                                      
REMARK 465     LEU C   687                                                      
REMARK 465     GLY C   688                                                      
REMARK 465     VAL C   689                                                      
REMARK 465     ASN C   690                                                      
REMARK 465     PRO C   691                                                      
REMARK 465     ALA C   692                                                      
REMARK 465     ALA C   693                                                      
REMARK 465     ASP C   694                                                      
REMARK 465     ASP C   695                                                      
REMARK 465     ASP C   696                                                      
REMARK 465     ASP C   697                                                      
REMARK 465     ASP C   698                                                      
REMARK 465     GLY C   699                                                      
REMARK 465     PRO C   700                                                      
REMARK 465     TYR C   701                                                      
REMARK 465     ALA C   702                                                      
REMARK 465     ASP C   703                                                      
REMARK 465     ASP C   704                                                      
REMARK 465     SER C   705                                                      
REMARK 465     MET D   -19                                                      
REMARK 465     GLY D   -18                                                      
REMARK 465     SER D   -17                                                      
REMARK 465     SER D   -16                                                      
REMARK 465     HIS D   -15                                                      
REMARK 465     HIS D   -14                                                      
REMARK 465     HIS D   -13                                                      
REMARK 465     HIS D   -12                                                      
REMARK 465     HIS D   -11                                                      
REMARK 465     HIS D   -10                                                      
REMARK 465     SER D    -9                                                      
REMARK 465     SER D    -8                                                      
REMARK 465     GLY D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     VAL D    -5                                                      
REMARK 465     PRO D    -4                                                      
REMARK 465     ARG D    -3                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     SER D    -1                                                      
REMARK 465     HIS D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D   206                                                      
REMARK 465     PHE D   207                                                      
REMARK 465     ALA D   278                                                      
REMARK 465     PHE D   279                                                      
REMARK 465     HIS D   280                                                      
REMARK 465     GLU D   281                                                      
REMARK 465     PHE D   282                                                      
REMARK 465     GLN D   283                                                      
REMARK 465     HIS D   402                                                      
REMARK 465     ASN D   403                                                      
REMARK 465     GLY D   404                                                      
REMARK 465     LEU D   405                                                      
REMARK 465     THR D   406                                                      
REMARK 465     THR D   407                                                      
REMARK 465     GLU D   408                                                      
REMARK 465     LEU D   409                                                      
REMARK 465     PRO D   410                                                      
REMARK 465     THR D   411                                                      
REMARK 465     ASP D   412                                                      
REMARK 465     LEU D   413                                                      
REMARK 465     ILE D   541                                                      
REMARK 465     GLU D   542                                                      
REMARK 465     THR D   543                                                      
REMARK 465     ASN D   544                                                      
REMARK 465     GLN D   545                                                      
REMARK 465     GLY D   640                                                      
REMARK 465     GLY D   641                                                      
REMARK 465     LYS D   642                                                      
REMARK 465     LYS D   643                                                      
REMARK 465     LEU D   644                                                      
REMARK 465     LYS D   645                                                      
REMARK 465     VAL D   646                                                      
REMARK 465     ALA D   647                                                      
REMARK 465     ARG D   648                                                      
REMARK 465     PRO D   649                                                      
REMARK 465     LEU D   650                                                      
REMARK 465     SER D   651                                                      
REMARK 465     VAL D   652                                                      
REMARK 465     PRO D   653                                                      
REMARK 465     GLY D   654                                                      
REMARK 465     SER D   655                                                      
REMARK 465     PRO D   656                                                      
REMARK 465     ARG D   657                                                      
REMARK 465     ASP D   658                                                      
REMARK 465     LEU D   659                                                      
REMARK 465     ARG D   660                                                      
REMARK 465     SER D   661                                                      
REMARK 465     ASN D   662                                                      
REMARK 465     SER D   663                                                      
REMARK 465     THR D   664                                                      
REMARK 465     VAL D   665                                                      
REMARK 465     TYR D   666                                                      
REMARK 465     MET D   667                                                      
REMARK 465     THR D   668                                                      
REMARK 465     PRO D   669                                                      
REMARK 465     GLY D   670                                                      
REMARK 465     ASP D   671                                                      
REMARK 465     LEU D   672                                                      
REMARK 465     GLY D   673                                                      
REMARK 465     THR D   674                                                      
REMARK 465     LEU D   675                                                      
REMARK 465     GLN D   676                                                      
REMARK 465     GLU D   677                                                      
REMARK 465     VAL D   678                                                      
REMARK 465     ASN D   679                                                      
REMARK 465     ASN D   680                                                      
REMARK 465     ALA D   681                                                      
REMARK 465     ASP D   682                                                      
REMARK 465     ASP D   683                                                      
REMARK 465     TYR D   684                                                      
REMARK 465     PHE D   685                                                      
REMARK 465     SER D   686                                                      
REMARK 465     LEU D   687                                                      
REMARK 465     GLY D   688                                                      
REMARK 465     VAL D   689                                                      
REMARK 465     ASN D   690                                                      
REMARK 465     PRO D   691                                                      
REMARK 465     ALA D   692                                                      
REMARK 465     ALA D   693                                                      
REMARK 465     ASP D   694                                                      
REMARK 465     ASP D   695                                                      
REMARK 465     ASP D   696                                                      
REMARK 465     ASP D   697                                                      
REMARK 465     ASP D   698                                                      
REMARK 465     GLY D   699                                                      
REMARK 465     PRO D   700                                                      
REMARK 465     TYR D   701                                                      
REMARK 465     ALA D   702                                                      
REMARK 465     ASP D   703                                                      
REMARK 465     ASP D   704                                                      
REMARK 465     SER D   705                                                      
REMARK 465     UNK E     6                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG A  20       94.74    -56.12                                   
REMARK 500    LYS A  40     -121.97     37.17                                   
REMARK 500    ALA A 100       69.59     34.79                                   
REMARK 500    VAL A 111      -11.41   -148.95                                   
REMARK 500    TYR A 114       20.62    -57.56                                   
REMARK 500    LEU A 125      -14.22   -144.25                                   
REMARK 500    VAL A 126       -1.60   -147.57                                   
REMARK 500    SER A 130       85.46   -162.18                                   
REMARK 500    SER A 159       20.66   -152.51                                   
REMARK 500    GLU A 169      154.58     70.57                                   
REMARK 500    ARG A 183       19.92     48.93                                   
REMARK 500    ILE A 184      143.94    -39.34                                   
REMARK 500    ASP A 185       54.21    -91.01                                   
REMARK 500    ALA A 194      174.42    166.47                                   
REMARK 500    PHE A 209      -79.64   -139.38                                   
REMARK 500    TYR A 210       -7.93    -55.77                                   
REMARK 500    PHE A 276      -63.99    -99.81                                   
REMARK 500    CYS A 304       57.44   -152.69                                   
REMARK 500    ASN A 362       59.32   -110.16                                   
REMARK 500    SER A 363     -168.10     52.85                                   
REMARK 500    PRO A 435      139.63    -36.99                                   
REMARK 500    VAL A 448       38.49    -80.04                                   
REMARK 500    ASP A 449       47.69    168.28                                   
REMARK 500    ILE A 487      -82.44    -95.92                                   
REMARK 500    GLU A 509       91.44   -170.56                                   
REMARK 500    THR A 527     -166.57   -119.30                                   
REMARK 500    LYS A 577       21.78    -79.37                                   
REMARK 500    GLU A 628     -168.51   -172.81                                   
REMARK 500    LYS B  40     -116.63     42.38                                   
REMARK 500    ALA B 100       62.06     33.72                                   
REMARK 500    ARG B 112       -8.48    -54.87                                   
REMARK 500    TYR B 114       19.86    -58.35                                   
REMARK 500    SER B 115      -71.44    -61.15                                   
REMARK 500    VAL B 126        6.82   -165.27                                   
REMARK 500    SER B 130       83.63   -163.63                                   
REMARK 500    GLU B 169      150.62     74.06                                   
REMARK 500    LEU B 171      -18.66    -49.66                                   
REMARK 500    ARG B 183       37.15     38.18                                   
REMARK 500    ALA B 194      164.38    151.82                                   
REMARK 500    PHE B 209      -80.72   -140.07                                   
REMARK 500    TYR B 210      -10.10    -49.00                                   
REMARK 500    ASN B 211      -64.38    -97.46                                   
REMARK 500    CYS B 212       31.14    -92.02                                   
REMARK 500    PHE B 276      -65.08   -101.21                                   
REMARK 500    CYS B 304       54.61   -159.05                                   
REMARK 500    TYR B 321       89.52    -69.44                                   
REMARK 500    TYR B 340      -72.87    -39.60                                   
REMARK 500    ARG B 341      -38.90    -37.98                                   
REMARK 500    ASN B 362       59.98   -116.16                                   
REMARK 500    SER B 363     -159.08     57.31                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     119 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR                        
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE                                    
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500    LEU C 285        24.7      L          L   OUTSIDE RANGE           
REMARK 500    LEU D 285        22.2      L          L   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 706                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 706                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 804                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1RZU   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 2BIS   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 2QZS   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3NB0   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3NCH   RELATED DB: PDB                                   
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 1) THE CRYSTALLIZED SEQUENCE HAS BEEN REFERENCED TO UNP ENTRY        
REMARK 999 P27472. HOWEVER, RESIDUE A535S IS ANNOTATED IN GENBANK ENTRY         
REMARK 999 ACCESSION CODE AAA88716. 2) CHAINS E AND F HAVE POOR ELECTRON        
REMARK 999 DENSITY. THEY COULD BE EITHER A SEGMENT OF THE C-TERMINAL DISORDER   
REMARK 999 REGION (RESIDUES 642-705) OR THE N-TERMINAL HIS-TAG FROM SYMMETRY    
REMARK 999 RELATED MOLECULE.                                                    
DBREF  3NAZ A    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3NAZ B    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3NAZ C    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3NAZ D    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3NAZ E    1     6  PDB    3NAZ     3NAZ             1      6             
DBREF  3NAZ F    1     6  PDB    3NAZ     3NAZ             1      6             
SEQADV 3NAZ MET A  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY A  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER A  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER A  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS A  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS A  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS A  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS A  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS A  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS A  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER A   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER A   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY A   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ LEU A   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ VAL A   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ PRO A   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ ARG A   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY A   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER A   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS A    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER A  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3NAZ ALA A  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3NAZ ALA A  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3NAZ ALA A  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQADV 3NAZ MET B  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY B  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER B  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER B  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS B  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS B  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS B  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS B  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS B  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS B  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER B   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER B   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY B   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ LEU B   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ VAL B   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ PRO B   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ ARG B   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY B   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER B   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS B    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER B  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3NAZ ALA B  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3NAZ ALA B  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3NAZ ALA B  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQADV 3NAZ MET C  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY C  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER C  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER C  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS C  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS C  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS C  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS C  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS C  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS C  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER C   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER C   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY C   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ LEU C   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ VAL C   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ PRO C   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ ARG C   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY C   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER C   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS C    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER C  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3NAZ ALA C  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3NAZ ALA C  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3NAZ ALA C  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQADV 3NAZ MET D  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY D  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER D  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER D  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS D  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS D  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS D  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS D  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS D  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS D  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER D   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER D   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY D   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ LEU D   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ VAL D   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ PRO D   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ ARG D   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ GLY D   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER D   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ HIS D    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3NAZ SER D  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3NAZ ALA D  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3NAZ ALA D  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3NAZ ALA D  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQRES   1 A  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 A  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 A  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 A  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 A  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 A  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 A  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 A  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 A  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 A  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 A  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 A  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 A  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 A  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 A  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 A  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 A  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 A  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 A  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 A  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 A  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 A  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 A  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 A  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 A  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 A  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 A  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 A  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 A  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 A  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 A  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 A  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 A  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 A  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 A  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 A  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 A  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 A  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 A  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 A  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 A  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 A  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 A  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 A  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 A  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 A  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 A  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 A  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 A  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 A  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 A  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 A  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 A  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 A  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 A  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 A  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 B  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 B  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 B  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 B  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 B  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 B  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 B  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 B  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 B  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 B  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 B  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 B  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 B  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 B  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 B  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 B  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 B  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 B  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 B  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 B  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 B  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 B  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 B  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 B  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 B  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 B  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 B  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 B  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 B  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 B  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 B  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 B  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 B  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 B  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 B  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 B  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 B  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 B  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 B  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 B  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 B  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 B  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 B  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 B  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 B  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 B  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 B  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 B  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 B  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 B  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 B  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 B  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 B  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 B  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 B  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 B  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 C  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 C  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 C  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 C  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 C  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 C  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 C  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 C  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 C  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 C  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 C  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 C  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 C  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 C  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 C  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 C  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 C  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 C  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 C  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 C  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 C  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 C  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 C  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 C  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 C  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 C  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 C  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 C  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 C  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 C  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 C  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 C  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 C  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 C  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 C  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 C  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 C  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 C  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 C  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 C  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 C  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 C  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 C  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 C  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 C  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 C  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 C  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 C  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 C  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 C  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 C  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 C  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 C  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 C  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 C  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 C  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 D  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 D  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 D  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 D  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 D  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 D  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 D  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 D  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 D  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 D  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 D  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 D  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 D  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 D  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 D  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 D  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 D  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 D  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 D  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 D  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 D  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 D  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 D  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 D  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 D  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 D  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 D  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 D  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 D  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 D  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 D  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 D  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 D  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 D  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 D  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 D  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 D  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 D  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 D  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 D  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 D  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 D  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 D  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 D  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 D  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 D  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 D  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 D  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 D  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 D  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 D  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 D  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 D  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 D  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 D  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 D  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 E    6  UNK UNK UNK UNK UNK UNK                                      
SEQRES   1 F    6  UNK UNK UNK UNK UNK UNK                                      
HET    SO4  A 801       5                                                       
HET    SO4  A 802       5                                                       
HET    SO4  D 803       5                                                       
HET    SO4  A 804       5                                                       
HET    SO4  B 801       5                                                       
HET    SO4  B 802       5                                                       
HET    SO4  C 803       5                                                       
HET    SO4  B 804       5                                                       
HET    SO4  C 801       5                                                       
HET    SO4  B 706       5                                                       
HET    SO4  C 706       5                                                       
HET    SO4  C 804       5                                                       
HET    SO4  D 801       5                                                       
HET    SO4  D 802       5                                                       
HET    SO4  A 803       5                                                       
HET    SO4  D 804       5                                                       
HETNAM     SO4 SULFATE ION                                                      
FORMUL   7  SO4    16(O4 S 2-)                                                  
HELIX    1   1 GLY A   23  LYS A   40  1                                  18    
HELIX    2   2 THR A   53  GLU A   57  1                                   5    
HELIX    3   3 MET A   73  ARG A   86  1                                  14    
HELIX    4   4 LEU A  108  GLY A  113  5                                   6    
HELIX    5   5 TYR A  114  GLY A  127  1                                  14    
HELIX    6   6 ASP A  134  ASP A  158  1                                  25    
HELIX    7   7 TRP A  170  GLY A  173  5                                   4    
HELIX    8   8 VAL A  174  ARG A  182  1                                   9    
HELIX    9   9 THR A  195  CYS A  202  1                                   8    
HELIX   10  10 ASP A  217  PHE A  225  1                                   9    
HELIX   11  11 ILE A  227  ALA A  241  1                                  15    
HELIX   12  12 SER A  248  LYS A  260  1                                  13    
HELIX   13  13 ASN A  272  PHE A  276  5                                   5    
HELIX   14  14 LEU A  285  PHE A  301  1                                  17    
HELIX   15  15 ASP A  308  ASP A  310  5                                   3    
HELIX   16  16 GLY A  327  SER A  345  1                                  19    
HELIX   17  17 THR A  365  ILE A  398  1                                  34    
HELIX   18  18 LYS A  418  ALA A  431  1                                  14    
HELIX   19  19 ASP A  453  VAL A  462  1                                  10    
HELIX   20  20 ASP A  491  CYS A  499  1                                   9    
HELIX   21  21 GLY A  512  MET A  521  1                                  10    
HELIX   22  22 SER A  531  ASP A  539  1                                   9    
HELIX   23  23 LEU A  540  LEU A  540  5                                   1    
HELIX   24  24 ALA A  546  TYR A  549  5                                   4    
HELIX   25  25 ALA A  560  LYS A  577  1                                  18    
HELIX   26  26 THR A  579  ARG A  592  1                                  14    
HELIX   27  27 LEU A  593  LEU A  597  5                                   5    
HELIX   28  28 ASP A  598  TYR A  618  1                                  21    
HELIX   29  29 TYR A  618  GLY A  627  1                                  10    
HELIX   30  30 ASN A  634  ALA A  639  1                                   6    
HELIX   31  31 GLY B   23  LYS B   40  1                                  18    
HELIX   32  32 THR B   53  GLU B   57  1                                   5    
HELIX   33  33 LYS B   65  PHE B   69  5                                   5    
HELIX   34  34 MET B   73  ARG B   86  1                                  14    
HELIX   35  35 VAL B  111  GLY B  113  5                                   3    
HELIX   36  36 TYR B  114  GLY B  127  1                                  14    
HELIX   37  37 ASP B  134  ASP B  158  1                                  25    
HELIX   38  38 TRP B  170  GLY B  173  5                                   4    
HELIX   39  39 VAL B  174  ARG B  182  1                                   9    
HELIX   40  40 THR B  195  ALA B  203  1                                   9    
HELIX   41  41 ASN B  211  VAL B  216  5                                   6    
HELIX   42  42 ASP B  217  PHE B  225  1                                   9    
HELIX   43  43 ILE B  227  ALA B  241  1                                  15    
HELIX   44  44 SER B  248  LYS B  260  1                                  13    
HELIX   45  45 ASN B  272  PHE B  276  5                                   5    
HELIX   46  46 LEU B  285  PHE B  301  1                                  17    
HELIX   47  47 ASP B  308  ASP B  310  5                                   3    
HELIX   48  48 GLY B  327  SER B  345  1                                  19    
HELIX   49  49 THR B  365  ARG B  399  1                                  35    
HELIX   50  50 LYS B  418  ALA B  431  1                                  14    
HELIX   51  51 ASP B  453  VAL B  462  1                                  10    
HELIX   52  52 ASP B  491  CYS B  499  1                                   9    
HELIX   53  53 GLY B  512  MET B  521  1                                  10    
HELIX   54  54 SER B  531  ASP B  539  1                                   9    
HELIX   55  55 ALA B  546  TYR B  549  5                                   4    
HELIX   56  56 ALA B  560  LYS B  577  1                                  18    
HELIX   57  57 THR B  579  SER B  594  1                                  16    
HELIX   58  58 ASP B  595  LEU B  597  5                                   3    
HELIX   59  59 ASP B  598  GLY B  603  1                                   6    
HELIX   60  60 GLY B  603  ARG B  616  1                                  14    
HELIX   61  61 TYR B  618  GLY B  627  1                                  10    
HELIX   62  62 ASN B  634  ALA B  639  1                                   6    
HELIX   63  63 GLY C   23  LYS C   40  1                                  18    
HELIX   64  64 THR C   53  GLU C   57  1                                   5    
HELIX   65  65 LYS C   65  PHE C   69  5                                   5    
HELIX   66  66 MET C   73  ARG C   86  1                                  14    
HELIX   67  67 LEU C  108  GLY C  113  5                                   6    
HELIX   68  68 TYR C  114  SER C  124  1                                  11    
HELIX   69  69 ASP C  134  ASP C  158  1                                  25    
HELIX   70  70 TRP C  170  GLY C  173  5                                   4    
HELIX   71  71 VAL C  174  ARG C  182  1                                   9    
HELIX   72  72 THR C  195  CYS C  202  1                                   8    
HELIX   73  73 ASP C  217  PHE C  225  1                                   9    
HELIX   74  74 ILE C  227  ALA C  241  1                                  15    
HELIX   75  75 SER C  248  LEU C  259  1                                  12    
HELIX   76  76 ASN C  272  PHE C  276  5                                   5    
HELIX   77  77 LEU C  285  HIS C  302  1                                  18    
HELIX   78  78 ASP C  308  ASP C  310  5                                   3    
HELIX   79  79 GLY C  327  SER C  345  1                                  19    
HELIX   80  80 THR C  365  TYR C  400  1                                  36    
HELIX   81  81 LYS C  418  ALA C  431  1                                  14    
HELIX   82  82 ASP C  453  VAL C  462  1                                  10    
HELIX   83  83 ASP C  491  CYS C  499  1                                   9    
HELIX   84  84 GLY C  512  MET C  521  1                                  10    
HELIX   85  85 SER C  531  ASP C  539  1                                   9    
HELIX   86  86 LEU C  540  LEU C  540  5                                   1    
HELIX   87  87 ALA C  546  TYR C  549  5                                   4    
HELIX   88  88 ALA C  560  LYS C  577  1                                  18    
HELIX   89  89 THR C  579  SER C  594  1                                  16    
HELIX   90  90 ASP C  595  LEU C  597  5                                   3    
HELIX   91  91 ASP C  598  TYR C  618  1                                  21    
HELIX   92  92 TYR C  618  GLY C  627  1                                  10    
HELIX   93  93 ASN C  634  ALA C  639  1                                   6    
HELIX   94  94 GLY D   23  LYS D   40  1                                  18    
HELIX   95  95 THR D   53  GLU D   57  1                                   5    
HELIX   96  96 LYS D   65  PHE D   69  5                                   5    
HELIX   97  97 MET D   73  ARG D   86  1                                  14    
HELIX   98  98 LEU D  108  GLY D  113  5                                   6    
HELIX   99  99 TYR D  114  GLY D  127  1                                  14    
HELIX  100 100 ASP D  134  ASP D  158  1                                  25    
HELIX  101 101 TRP D  170  GLY D  173  5                                   4    
HELIX  102 102 VAL D  174  ARG D  182  1                                   9    
HELIX  103 103 THR D  195  ALA D  203  1                                   9    
HELIX  104 104 ASP D  217  PHE D  225  1                                   9    
HELIX  105 105 ILE D  227  ALA D  241  1                                  15    
HELIX  106 106 SER D  248  LEU D  259  1                                  12    
HELIX  107 107 ASN D  272  PHE D  276  5                                   5    
HELIX  108 108 LEU D  285  PHE D  301  1                                  17    
HELIX  109 109 ASP D  308  ASP D  310  5                                   3    
HELIX  110 110 GLY D  327  SER D  345  1                                  19    
HELIX  111 111 THR D  365  TYR D  400  1                                  36    
HELIX  112 112 LYS D  418  ALA D  431  1                                  14    
HELIX  113 113 ASP D  453  VAL D  462  1                                  10    
HELIX  114 114 ASP D  491  CYS D  499  1                                   9    
HELIX  115 115 GLY D  512  MET D  521  1                                  10    
HELIX  116 116 SER D  531  ASP D  539  1                                   9    
HELIX  117 117 ALA D  546  TYR D  549  5                                   4    
HELIX  118 118 ALA D  560  LYS D  577  1                                  18    
HELIX  119 119 THR D  579  SER D  594  1                                  16    
HELIX  120 120 ASP D  595  LEU D  597  5                                   3    
HELIX  121 121 ASP D  598  TYR D  618  1                                  21    
HELIX  122 122 TYR D  618  GLY D  627  1                                  10    
HELIX  123 123 ASN D  634  ALA D  639  1                                   6    
SHEET    1   A 9 VAL A  58  ILE A  60  0                                        
SHEET    2   A 9 PHE A  90  TRP A  95 -1  O  ARG A  94   N  ASP A  59           
SHEET    3   A 9 LYS A 102  PHE A 106 -1  O  VAL A 103   N  GLY A  93           
SHEET    4   A 9 TYR A  43  PRO A  48  1  N  LEU A  45   O  ILE A 104           
SHEET    5   A 9 ASP A   4  THR A  13  1  N  GLU A  12   O  ILE A  46           
SHEET    6   A 9 HIS A 161  HIS A 168  1  O  HIS A 166   N  THR A  13           
SHEET    7   A 9 VAL A 186  THR A 192  1  O  ILE A 189   N  PHE A 167           
SHEET    8   A 9 VAL A 243  THR A 246  1  O  THR A 245   N  PHE A 190           
SHEET    9   A 9 GLY A 265  ILE A 266  1  O  GLY A 265   N  THR A 246           
SHEET    1   B 6 VAL A 472  PHE A 476  0                                        
SHEET    2   B 6 THR A 350  VAL A 356  1  N  VAL A 351   O  LYS A 473           
SHEET    3   B 6 THR A 312  ALA A 318  1  N  LEU A 313   O  THR A 350           
SHEET    4   B 6 LEU A 501  VAL A 503  1  O  VAL A 503   N  PHE A 316           
SHEET    5   B 6 SER A 525  THR A 528  1  O  ILE A 526   N  GLY A 502           
SHEET    6   B 6 ILE A 551  VAL A 554  1  O  VAL A 554   N  THR A 527           
SHEET    1   C 2 ASN A 361  PHE A 364  0                                        
SHEET    2   C 2 HIS A 445  MET A 447 -1  O  ASN A 446   N  ASN A 362           
SHEET    1   D 9 VAL B  58  ILE B  60  0                                        
SHEET    2   D 9 PHE B  90  TRP B  95 -1  O  ARG B  94   N  ASP B  59           
SHEET    3   D 9 LYS B 102  PHE B 106 -1  O  LEU B 105   N  VAL B  91           
SHEET    4   D 9 TYR B  43  PRO B  48  1  N  LEU B  45   O  ILE B 104           
SHEET    5   D 9 ASP B   4  THR B  13  1  N  GLU B  12   O  ILE B  46           
SHEET    6   D 9 HIS B 161  HIS B 168  1  O  HIS B 166   N  THR B  13           
SHEET    7   D 9 VAL B 186  THR B 192  1  O  ILE B 189   N  ALA B 165           
SHEET    8   D 9 VAL B 243  THR B 246  1  O  THR B 245   N  PHE B 190           
SHEET    9   D 9 GLY B 265  ILE B 266  1  O  GLY B 265   N  THR B 246           
SHEET    1   E 6 VAL B 472  PHE B 476  0                                        
SHEET    2   E 6 THR B 350  VAL B 356  1  N  ALA B 353   O  ILE B 475           
SHEET    3   E 6 THR B 312  ALA B 318  1  N  ILE B 317   O  VAL B 356           
SHEET    4   E 6 LEU B 501  VAL B 503  1  O  VAL B 503   N  PHE B 316           
SHEET    5   E 6 SER B 525  THR B 528  1  O  ILE B 526   N  GLY B 502           
SHEET    6   E 6 ILE B 551  VAL B 554  1  O  TYR B 552   N  THR B 527           
SHEET    1   F 2 ASN B 361  PHE B 364  0                                        
SHEET    2   F 2 HIS B 445  MET B 447 -1  O  ASN B 446   N  SER B 363           
SHEET    1   G 9 VAL C  58  ILE C  60  0                                        
SHEET    2   G 9 PHE C  90  TRP C  95 -1  O  ARG C  94   N  ASP C  59           
SHEET    3   G 9 LYS C 102  PHE C 106 -1  O  VAL C 103   N  GLY C  93           
SHEET    4   G 9 TYR C  43  PRO C  48  1  N  LEU C  45   O  ILE C 104           
SHEET    5   G 9 ASP C   4  THR C  13  1  N  GLU C  12   O  ILE C  46           
SHEET    6   G 9 HIS C 161  HIS C 168  1  O  HIS C 166   N  THR C  13           
SHEET    7   G 9 VAL C 187  THR C 192  1  O  ILE C 189   N  PHE C 167           
SHEET    8   G 9 VAL C 243  THR C 246  1  O  VAL C 243   N  PHE C 190           
SHEET    9   G 9 GLY C 265  ILE C 266  1  O  GLY C 265   N  THR C 246           
SHEET    1   H 6 VAL C 472  PHE C 476  0                                        
SHEET    2   H 6 THR C 350  VAL C 356  1  N  ALA C 353   O  ILE C 475           
SHEET    3   H 6 THR C 312  ALA C 318  1  N  PHE C 315   O  PHE C 354           
SHEET    4   H 6 LEU C 501  VAL C 503  1  O  VAL C 503   N  PHE C 316           
SHEET    5   H 6 SER C 525  THR C 528  1  O  ILE C 526   N  GLY C 502           
SHEET    6   H 6 ILE C 551  VAL C 554  1  O  TYR C 552   N  THR C 527           
SHEET    1   I 2 ASN C 361  PHE C 364  0                                        
SHEET    2   I 2 HIS C 445  MET C 447 -1  O  ASN C 446   N  ASN C 362           
SHEET    1   J 8 VAL D  58  ILE D  60  0                                        
SHEET    2   J 8 PHE D  90  TRP D  95 -1  O  ARG D  94   N  ASP D  59           
SHEET    3   J 8 LYS D 102  PHE D 106 -1  O  LEU D 105   N  VAL D  91           
SHEET    4   J 8 TYR D  43  PRO D  48  1  N  LEU D  45   O  ILE D 104           
SHEET    5   J 8 ASP D   4  THR D  13  1  N  LEU D  10   O  HIS D  44           
SHEET    6   J 8 HIS D 161  HIS D 168  1  O  HIS D 166   N  THR D  13           
SHEET    7   J 8 VAL D 187  THR D 192  1  O  VAL D 187   N  ALA D 165           
SHEET    8   J 8 VAL D 243  THR D 246  1  O  THR D 245   N  PHE D 190           
SHEET    1   K 6 VAL D 472  PHE D 476  0                                        
SHEET    2   K 6 THR D 350  VAL D 356  1  N  ALA D 353   O  LYS D 473           
SHEET    3   K 6 THR D 312  ALA D 318  1  N  PHE D 315   O  PHE D 354           
SHEET    4   K 6 LEU D 501  VAL D 503  1  O  VAL D 503   N  PHE D 316           
SHEET    5   K 6 SER D 525  THR D 528  1  O  ILE D 526   N  GLY D 502           
SHEET    6   K 6 ILE D 551  VAL D 554  1  O  TYR D 552   N  THR D 527           
SHEET    1   L 2 ASN D 361  PHE D 364  0                                        
SHEET    2   L 2 HIS D 445  MET D 447 -1  O  ASN D 446   N  ASN D 362           
CISPEP   1 TYR A  400    PRO A  401          0         0.28                     
CISPEP   2 TYR B  400    PRO B  401          0        -2.49                     
CISPEP   3 TYR C  400    PRO C  401          0        -2.12                     
CISPEP   4 TYR D  400    PRO D  401          0        -3.46                     
SITE     1 AC1  4 ARG A  20  SER A  26  LYS A  29  LYS A 275                    
SITE     1 AC2  3 ARG A 320  GLY A 512  TYR A 513                               
SITE     1 AC3  3 ARG A  20  ARG D 427  ARG D 428                               
SITE     1 AC4  3 GLN A 582  ASN A 585  ARG A 589                               
SITE     1 AC5  4 ARG B  20  SER B  26  LYS B  29  LYS B 275                    
SITE     1 AC6  4 ARG B 320  LYS B 326  GLY B 512  TYR B 513                    
SITE     1 AC7  2 ARG C 427  ARG C 428                                          
SITE     1 AC8  3 GLN B 582  ASN B 585  ARG B 589                               
SITE     1 AC9  4 ARG C  20  SER C  26  LYS C  29  LYS C 275                    
SITE     1 BC1  3 ARG B 427  ARG B 428  ARG C  20                               
SITE     1 BC2  4 ARG C 199  ARG C 320  LYS C 326  GLY C 512                    
SITE     1 BC3  2 ASN C 585  ARG C 589                                          
SITE     1 BC4  4 ARG D 320  LYS D 326  GLY D 512  TYR D 513                    
SITE     1 BC5  3 ARG D  20  SER D  26  LYS D  29                               
SITE     1 BC6  3 ARG A 427  ARG A 428  ARG D  20                               
SITE     1 BC7  2 ASN D 585  ARG D 589                                          
CRYST1   96.529  166.154  121.029  90.00 103.39  90.00 P 1 21 1      8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.010360  0.000000  0.002466        0.00000                         
SCALE2      0.000000  0.006019  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.008493        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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