GenomeNet

Database: PDB
Entry: 3O3C
LinkDB: 3O3C
Original site: 3O3C 
HEADER    TRANSFERASE                             23-JUL-10   3O3C              
TITLE     GLYCOGEN SYNTHASE BASAL STATE UDP COMPLEX                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: GLYCOGEN [STARCH] SYNTHASE ISOFORM 2;                      
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 EC: 2.4.1.11;                                                        
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BREWER'S YEAST,LAGER BEER YEAST,YEAST;              
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 GENE: GSY2, YLR258W, L8479.8;                                        
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET28A                                    
KEYWDS    GLYCOGEN SYNTHASE, TRANSFERASE                                        
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    S.BASKARAN,T.D.HURLEY                                                 
REVDAT   3   20-OCT-10 3O3C    1       JRNL                                     
REVDAT   2   13-OCT-10 3O3C    1       JRNL                                     
REVDAT   1   06-OCT-10 3O3C    0                                                
JRNL        AUTH   S.BASKARAN,P.J.ROACH,A.A.DEPAOLI-ROACH,T.D.HURLEY            
JRNL        TITL   STRUCTURAL BASIS FOR GLUCOSE-6-PHOSPHATE ACTIVATION OF       
JRNL        TITL 2 GLYCOGEN SYNTHASE.                                           
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 107 17563 2010              
JRNL        REFN                   ISSN 0027-8424                               
JRNL        PMID   20876143                                                     
JRNL        DOI    10.1073/PNAS.1006340107                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.51 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE)                               
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.51                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.29                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.360                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 50.2                           
REMARK   3   NUMBER OF REFLECTIONS             : 46330                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.221                           
REMARK   3   R VALUE            (WORKING SET) : 0.219                           
REMARK   3   FREE R VALUE                     : 0.249                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.150                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2384                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 48.2921 -  9.0127    0.51     2649   151  0.1905 0.2142        
REMARK   3     2  9.0127 -  7.1611    0.51     2642   127  0.1598 0.1917        
REMARK   3     3  7.1611 -  6.2581    0.51     2630   143  0.1902 0.2212        
REMARK   3     4  6.2581 -  5.6869    0.51     2627   125  0.2099 0.2661        
REMARK   3     5  5.6869 -  5.2798    0.51     2607   145  0.2031 0.2358        
REMARK   3     6  5.2798 -  4.9689    0.51     2624   158  0.1982 0.2374        
REMARK   3     7  4.9689 -  4.7202    0.51     2612   136  0.1902 0.2213        
REMARK   3     8  4.7202 -  4.5149    0.51     2610   130  0.2067 0.2375        
REMARK   3     9  4.5149 -  4.3412    0.51     2585   163  0.2133 0.2912        
REMARK   3    10  4.3412 -  4.1915    0.51     2592   139  0.2262 0.2487        
REMARK   3    11  4.1915 -  4.0605    0.50     2609   149  0.2346 0.2521        
REMARK   3    12  4.0605 -  3.9445    0.50     2585   157  0.2480 0.2699        
REMARK   3    13  3.9445 -  3.8407    0.50     2566   151  0.2555 0.2499        
REMARK   3    14  3.8407 -  3.7470    0.50     2586   144  0.2746 0.2775        
REMARK   3    15  3.7470 -  3.6619    0.49     2530   124  0.2728 0.2694        
REMARK   3    16  3.6619 -  3.5840    0.49     2519   129  0.2979 0.3036        
REMARK   3    17  3.5840 -  3.5123    0.46     2373   113  0.3098 0.3326        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : 0.33                                          
REMARK   3   B_SOL              : 60.34                                         
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : -0.000           
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 25.030           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -3.09520                                             
REMARK   3    B22 (A**2) : 20.07380                                             
REMARK   3    B33 (A**2) : -16.97860                                            
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 6.01250                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.009          20300                                  
REMARK   3   ANGLE     :  1.114          27502                                  
REMARK   3   CHIRALITY :  0.076           2984                                  
REMARK   3   PLANARITY :  0.005           3532                                  
REMARK   3   DIHEDRAL  : 19.818           7340                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 3O3C COMPLIES WITH FORMAT V. 3.20, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-JUL-10.                  
REMARK 100 THE RCSB ID CODE IS RCSB060612.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 01-AUG-09                          
REMARK 200  TEMPERATURE           (KELVIN) : NULL                               
REMARK 200  PH                             : 8.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 23-ID-B                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.01                               
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MAR CCD 130 MM                     
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 46381                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.510                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.0                               
REMARK 200  DATA REDUNDANCY                : 3.600                              
REMARK 200  R MERGE                    (I) : 0.11000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 13.0000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.51                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.57                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 92.7                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.70                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.44400                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: AMORE                                                 
REMARK 200 STARTING MODEL: PDB ENTRY 3NAZ                                       
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 57.72                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.91                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM TRIS PH 8.0, 20% PEG 3500, 200    
REMARK 280  MM LI2SO4, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K          
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       83.60450            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 12940 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 96370 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -227.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, B, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -19                                                      
REMARK 465     GLY A   -18                                                      
REMARK 465     SER A   -17                                                      
REMARK 465     SER A   -16                                                      
REMARK 465     HIS A   -15                                                      
REMARK 465     HIS A   -14                                                      
REMARK 465     HIS A   -13                                                      
REMARK 465     HIS A   -12                                                      
REMARK 465     HIS A   -11                                                      
REMARK 465     HIS A   -10                                                      
REMARK 465     SER A    -9                                                      
REMARK 465     SER A    -8                                                      
REMARK 465     GLY A    -7                                                      
REMARK 465     LEU A    -6                                                      
REMARK 465     VAL A    -5                                                      
REMARK 465     PRO A    -4                                                      
REMARK 465     ARG A    -3                                                      
REMARK 465     GLY A    -2                                                      
REMARK 465     SER A    -1                                                      
REMARK 465     HIS A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     SER A   206                                                      
REMARK 465     PHE A   207                                                      
REMARK 465     ALA A   278                                                      
REMARK 465     PHE A   279                                                      
REMARK 465     HIS A   280                                                      
REMARK 465     GLU A   281                                                      
REMARK 465     PHE A   282                                                      
REMARK 465     GLN A   283                                                      
REMARK 465     ASN A   284                                                      
REMARK 465     HIS A   402                                                      
REMARK 465     ASN A   403                                                      
REMARK 465     GLY A   404                                                      
REMARK 465     LEU A   405                                                      
REMARK 465     THR A   406                                                      
REMARK 465     THR A   407                                                      
REMARK 465     GLU A   408                                                      
REMARK 465     LEU A   409                                                      
REMARK 465     PRO A   410                                                      
REMARK 465     THR A   411                                                      
REMARK 465     ASP A   412                                                      
REMARK 465     LEU A   413                                                      
REMARK 465     GLY A   414                                                      
REMARK 465     ILE A   541                                                      
REMARK 465     GLU A   542                                                      
REMARK 465     THR A   543                                                      
REMARK 465     ASN A   544                                                      
REMARK 465     GLN A   545                                                      
REMARK 465     GLY A   640                                                      
REMARK 465     GLY A   641                                                      
REMARK 465     LYS A   642                                                      
REMARK 465     LYS A   643                                                      
REMARK 465     LEU A   644                                                      
REMARK 465     LYS A   645                                                      
REMARK 465     VAL A   646                                                      
REMARK 465     ALA A   647                                                      
REMARK 465     ARG A   648                                                      
REMARK 465     PRO A   649                                                      
REMARK 465     LEU A   650                                                      
REMARK 465     SER A   651                                                      
REMARK 465     VAL A   652                                                      
REMARK 465     PRO A   653                                                      
REMARK 465     GLY A   654                                                      
REMARK 465     SER A   655                                                      
REMARK 465     PRO A   656                                                      
REMARK 465     ARG A   657                                                      
REMARK 465     ASP A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     ARG A   660                                                      
REMARK 465     SER A   661                                                      
REMARK 465     ASN A   662                                                      
REMARK 465     SER A   663                                                      
REMARK 465     THR A   664                                                      
REMARK 465     VAL A   665                                                      
REMARK 465     TYR A   666                                                      
REMARK 465     MET A   667                                                      
REMARK 465     THR A   668                                                      
REMARK 465     PRO A   669                                                      
REMARK 465     GLY A   670                                                      
REMARK 465     ASP A   671                                                      
REMARK 465     LEU A   672                                                      
REMARK 465     GLY A   673                                                      
REMARK 465     THR A   674                                                      
REMARK 465     LEU A   675                                                      
REMARK 465     GLN A   676                                                      
REMARK 465     GLU A   677                                                      
REMARK 465     VAL A   678                                                      
REMARK 465     ASN A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     ALA A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     ASP A   683                                                      
REMARK 465     TYR A   684                                                      
REMARK 465     PHE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     GLY A   688                                                      
REMARK 465     VAL A   689                                                      
REMARK 465     ASN A   690                                                      
REMARK 465     PRO A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     ALA A   693                                                      
REMARK 465     ASP A   694                                                      
REMARK 465     ASP A   695                                                      
REMARK 465     ASP A   696                                                      
REMARK 465     ASP A   697                                                      
REMARK 465     ASP A   698                                                      
REMARK 465     GLY A   699                                                      
REMARK 465     PRO A   700                                                      
REMARK 465     TYR A   701                                                      
REMARK 465     ALA A   702                                                      
REMARK 465     ASP A   703                                                      
REMARK 465     ASP A   704                                                      
REMARK 465     SER A   705                                                      
REMARK 465     MET B   -19                                                      
REMARK 465     GLY B   -18                                                      
REMARK 465     SER B   -17                                                      
REMARK 465     SER B   -16                                                      
REMARK 465     HIS B   -15                                                      
REMARK 465     HIS B   -14                                                      
REMARK 465     HIS B   -13                                                      
REMARK 465     HIS B   -12                                                      
REMARK 465     HIS B   -11                                                      
REMARK 465     HIS B   -10                                                      
REMARK 465     SER B    -9                                                      
REMARK 465     SER B    -8                                                      
REMARK 465     GLY B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     VAL B    -5                                                      
REMARK 465     PRO B    -4                                                      
REMARK 465     ARG B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     SER B    -1                                                      
REMARK 465     HIS B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B   206                                                      
REMARK 465     PHE B   207                                                      
REMARK 465     ALA B   278                                                      
REMARK 465     PHE B   279                                                      
REMARK 465     HIS B   280                                                      
REMARK 465     GLU B   281                                                      
REMARK 465     PHE B   282                                                      
REMARK 465     GLN B   283                                                      
REMARK 465     ASN B   284                                                      
REMARK 465     HIS B   402                                                      
REMARK 465     ASN B   403                                                      
REMARK 465     GLY B   404                                                      
REMARK 465     LEU B   405                                                      
REMARK 465     THR B   406                                                      
REMARK 465     THR B   407                                                      
REMARK 465     GLU B   408                                                      
REMARK 465     LEU B   409                                                      
REMARK 465     PRO B   410                                                      
REMARK 465     THR B   411                                                      
REMARK 465     ASP B   412                                                      
REMARK 465     LEU B   413                                                      
REMARK 465     GLY B   414                                                      
REMARK 465     ILE B   541                                                      
REMARK 465     GLU B   542                                                      
REMARK 465     THR B   543                                                      
REMARK 465     ASN B   544                                                      
REMARK 465     GLN B   545                                                      
REMARK 465     GLY B   640                                                      
REMARK 465     GLY B   641                                                      
REMARK 465     LYS B   642                                                      
REMARK 465     LYS B   643                                                      
REMARK 465     LEU B   644                                                      
REMARK 465     LYS B   645                                                      
REMARK 465     VAL B   646                                                      
REMARK 465     ALA B   647                                                      
REMARK 465     ARG B   648                                                      
REMARK 465     PRO B   649                                                      
REMARK 465     LEU B   650                                                      
REMARK 465     SER B   651                                                      
REMARK 465     VAL B   652                                                      
REMARK 465     PRO B   653                                                      
REMARK 465     GLY B   654                                                      
REMARK 465     SER B   655                                                      
REMARK 465     PRO B   656                                                      
REMARK 465     ARG B   657                                                      
REMARK 465     ASP B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     ARG B   660                                                      
REMARK 465     SER B   661                                                      
REMARK 465     ASN B   662                                                      
REMARK 465     SER B   663                                                      
REMARK 465     THR B   664                                                      
REMARK 465     VAL B   665                                                      
REMARK 465     TYR B   666                                                      
REMARK 465     MET B   667                                                      
REMARK 465     THR B   668                                                      
REMARK 465     PRO B   669                                                      
REMARK 465     GLY B   670                                                      
REMARK 465     ASP B   671                                                      
REMARK 465     LEU B   672                                                      
REMARK 465     GLY B   673                                                      
REMARK 465     THR B   674                                                      
REMARK 465     LEU B   675                                                      
REMARK 465     GLN B   676                                                      
REMARK 465     GLU B   677                                                      
REMARK 465     VAL B   678                                                      
REMARK 465     ASN B   679                                                      
REMARK 465     ASN B   680                                                      
REMARK 465     ALA B   681                                                      
REMARK 465     ASP B   682                                                      
REMARK 465     ASP B   683                                                      
REMARK 465     TYR B   684                                                      
REMARK 465     PHE B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     LEU B   687                                                      
REMARK 465     GLY B   688                                                      
REMARK 465     VAL B   689                                                      
REMARK 465     ASN B   690                                                      
REMARK 465     PRO B   691                                                      
REMARK 465     ALA B   692                                                      
REMARK 465     ALA B   693                                                      
REMARK 465     ASP B   694                                                      
REMARK 465     ASP B   695                                                      
REMARK 465     ASP B   696                                                      
REMARK 465     ASP B   697                                                      
REMARK 465     ASP B   698                                                      
REMARK 465     GLY B   699                                                      
REMARK 465     PRO B   700                                                      
REMARK 465     TYR B   701                                                      
REMARK 465     ALA B   702                                                      
REMARK 465     ASP B   703                                                      
REMARK 465     ASP B   704                                                      
REMARK 465     SER B   705                                                      
REMARK 465     MET C   -19                                                      
REMARK 465     GLY C   -18                                                      
REMARK 465     SER C   -17                                                      
REMARK 465     SER C   -16                                                      
REMARK 465     HIS C   -15                                                      
REMARK 465     HIS C   -14                                                      
REMARK 465     HIS C   -13                                                      
REMARK 465     HIS C   -12                                                      
REMARK 465     HIS C   -11                                                      
REMARK 465     HIS C   -10                                                      
REMARK 465     SER C    -9                                                      
REMARK 465     SER C    -8                                                      
REMARK 465     GLY C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     VAL C    -5                                                      
REMARK 465     PRO C    -4                                                      
REMARK 465     ARG C    -3                                                      
REMARK 465     GLY C    -2                                                      
REMARK 465     SER C    -1                                                      
REMARK 465     HIS C     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C   206                                                      
REMARK 465     PHE C   207                                                      
REMARK 465     ALA C   278                                                      
REMARK 465     PHE C   279                                                      
REMARK 465     HIS C   280                                                      
REMARK 465     GLU C   281                                                      
REMARK 465     PHE C   282                                                      
REMARK 465     GLN C   283                                                      
REMARK 465     ASN C   284                                                      
REMARK 465     HIS C   402                                                      
REMARK 465     ASN C   403                                                      
REMARK 465     GLY C   404                                                      
REMARK 465     LEU C   405                                                      
REMARK 465     THR C   406                                                      
REMARK 465     THR C   407                                                      
REMARK 465     GLU C   408                                                      
REMARK 465     LEU C   409                                                      
REMARK 465     PRO C   410                                                      
REMARK 465     THR C   411                                                      
REMARK 465     ASP C   412                                                      
REMARK 465     LEU C   413                                                      
REMARK 465     GLY C   414                                                      
REMARK 465     ILE C   541                                                      
REMARK 465     GLU C   542                                                      
REMARK 465     THR C   543                                                      
REMARK 465     ASN C   544                                                      
REMARK 465     GLN C   545                                                      
REMARK 465     GLY C   640                                                      
REMARK 465     GLY C   641                                                      
REMARK 465     LYS C   642                                                      
REMARK 465     LYS C   643                                                      
REMARK 465     LEU C   644                                                      
REMARK 465     LYS C   645                                                      
REMARK 465     VAL C   646                                                      
REMARK 465     ALA C   647                                                      
REMARK 465     ARG C   648                                                      
REMARK 465     PRO C   649                                                      
REMARK 465     LEU C   650                                                      
REMARK 465     SER C   651                                                      
REMARK 465     VAL C   652                                                      
REMARK 465     PRO C   653                                                      
REMARK 465     GLY C   654                                                      
REMARK 465     SER C   655                                                      
REMARK 465     PRO C   656                                                      
REMARK 465     ARG C   657                                                      
REMARK 465     ASP C   658                                                      
REMARK 465     LEU C   659                                                      
REMARK 465     ARG C   660                                                      
REMARK 465     SER C   661                                                      
REMARK 465     ASN C   662                                                      
REMARK 465     SER C   663                                                      
REMARK 465     THR C   664                                                      
REMARK 465     VAL C   665                                                      
REMARK 465     TYR C   666                                                      
REMARK 465     MET C   667                                                      
REMARK 465     THR C   668                                                      
REMARK 465     PRO C   669                                                      
REMARK 465     GLY C   670                                                      
REMARK 465     ASP C   671                                                      
REMARK 465     LEU C   672                                                      
REMARK 465     GLY C   673                                                      
REMARK 465     THR C   674                                                      
REMARK 465     LEU C   675                                                      
REMARK 465     GLN C   676                                                      
REMARK 465     GLU C   677                                                      
REMARK 465     VAL C   678                                                      
REMARK 465     ASN C   679                                                      
REMARK 465     ASN C   680                                                      
REMARK 465     ALA C   681                                                      
REMARK 465     ASP C   682                                                      
REMARK 465     ASP C   683                                                      
REMARK 465     TYR C   684                                                      
REMARK 465     PHE C   685                                                      
REMARK 465     SER C   686                                                      
REMARK 465     LEU C   687                                                      
REMARK 465     GLY C   688                                                      
REMARK 465     VAL C   689                                                      
REMARK 465     ASN C   690                                                      
REMARK 465     PRO C   691                                                      
REMARK 465     ALA C   692                                                      
REMARK 465     ALA C   693                                                      
REMARK 465     ASP C   694                                                      
REMARK 465     ASP C   695                                                      
REMARK 465     ASP C   696                                                      
REMARK 465     ASP C   697                                                      
REMARK 465     ASP C   698                                                      
REMARK 465     GLY C   699                                                      
REMARK 465     PRO C   700                                                      
REMARK 465     TYR C   701                                                      
REMARK 465     ALA C   702                                                      
REMARK 465     ASP C   703                                                      
REMARK 465     ASP C   704                                                      
REMARK 465     SER C   705                                                      
REMARK 465     MET D   -19                                                      
REMARK 465     GLY D   -18                                                      
REMARK 465     SER D   -17                                                      
REMARK 465     SER D   -16                                                      
REMARK 465     HIS D   -15                                                      
REMARK 465     HIS D   -14                                                      
REMARK 465     HIS D   -13                                                      
REMARK 465     HIS D   -12                                                      
REMARK 465     HIS D   -11                                                      
REMARK 465     HIS D   -10                                                      
REMARK 465     SER D    -9                                                      
REMARK 465     SER D    -8                                                      
REMARK 465     GLY D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     VAL D    -5                                                      
REMARK 465     PRO D    -4                                                      
REMARK 465     ARG D    -3                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     SER D    -1                                                      
REMARK 465     HIS D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D   206                                                      
REMARK 465     PHE D   207                                                      
REMARK 465     ALA D   278                                                      
REMARK 465     PHE D   279                                                      
REMARK 465     HIS D   280                                                      
REMARK 465     GLU D   281                                                      
REMARK 465     PHE D   282                                                      
REMARK 465     GLN D   283                                                      
REMARK 465     ASN D   284                                                      
REMARK 465     HIS D   402                                                      
REMARK 465     ASN D   403                                                      
REMARK 465     GLY D   404                                                      
REMARK 465     LEU D   405                                                      
REMARK 465     THR D   406                                                      
REMARK 465     THR D   407                                                      
REMARK 465     GLU D   408                                                      
REMARK 465     LEU D   409                                                      
REMARK 465     PRO D   410                                                      
REMARK 465     THR D   411                                                      
REMARK 465     ASP D   412                                                      
REMARK 465     LEU D   413                                                      
REMARK 465     GLY D   414                                                      
REMARK 465     ILE D   541                                                      
REMARK 465     GLU D   542                                                      
REMARK 465     THR D   543                                                      
REMARK 465     ASN D   544                                                      
REMARK 465     GLN D   545                                                      
REMARK 465     GLY D   640                                                      
REMARK 465     GLY D   641                                                      
REMARK 465     LYS D   642                                                      
REMARK 465     LYS D   643                                                      
REMARK 465     LEU D   644                                                      
REMARK 465     LYS D   645                                                      
REMARK 465     VAL D   646                                                      
REMARK 465     ALA D   647                                                      
REMARK 465     ARG D   648                                                      
REMARK 465     PRO D   649                                                      
REMARK 465     LEU D   650                                                      
REMARK 465     SER D   651                                                      
REMARK 465     VAL D   652                                                      
REMARK 465     PRO D   653                                                      
REMARK 465     GLY D   654                                                      
REMARK 465     SER D   655                                                      
REMARK 465     PRO D   656                                                      
REMARK 465     ARG D   657                                                      
REMARK 465     ASP D   658                                                      
REMARK 465     LEU D   659                                                      
REMARK 465     ARG D   660                                                      
REMARK 465     SER D   661                                                      
REMARK 465     ASN D   662                                                      
REMARK 465     SER D   663                                                      
REMARK 465     THR D   664                                                      
REMARK 465     VAL D   665                                                      
REMARK 465     TYR D   666                                                      
REMARK 465     MET D   667                                                      
REMARK 465     THR D   668                                                      
REMARK 465     PRO D   669                                                      
REMARK 465     GLY D   670                                                      
REMARK 465     ASP D   671                                                      
REMARK 465     LEU D   672                                                      
REMARK 465     GLY D   673                                                      
REMARK 465     THR D   674                                                      
REMARK 465     LEU D   675                                                      
REMARK 465     GLN D   676                                                      
REMARK 465     GLU D   677                                                      
REMARK 465     VAL D   678                                                      
REMARK 465     ASN D   679                                                      
REMARK 465     ASN D   680                                                      
REMARK 465     ALA D   681                                                      
REMARK 465     ASP D   682                                                      
REMARK 465     ASP D   683                                                      
REMARK 465     TYR D   684                                                      
REMARK 465     PHE D   685                                                      
REMARK 465     SER D   686                                                      
REMARK 465     LEU D   687                                                      
REMARK 465     GLY D   688                                                      
REMARK 465     VAL D   689                                                      
REMARK 465     ASN D   690                                                      
REMARK 465     PRO D   691                                                      
REMARK 465     ALA D   692                                                      
REMARK 465     ALA D   693                                                      
REMARK 465     ASP D   694                                                      
REMARK 465     ASP D   695                                                      
REMARK 465     ASP D   696                                                      
REMARK 465     ASP D   697                                                      
REMARK 465     ASP D   698                                                      
REMARK 465     GLY D   699                                                      
REMARK 465     PRO D   700                                                      
REMARK 465     TYR D   701                                                      
REMARK 465     ALA D   702                                                      
REMARK 465     ASP D   703                                                      
REMARK 465     ASP D   704                                                      
REMARK 465     SER D   705                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    GLY B   532     OG   SER B   535              2.03            
REMARK 500   O    GLY D   532     OG   SER D   535              2.03            
REMARK 500   O    GLY A   532     OG   SER A   535              2.06            
REMARK 500   O    GLY C   532     OG   SER C   535              2.06            
REMARK 500   NH2  ARG B   399     O    PHE D   307              2.10            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO A 505   C   -  N   -  CA  ANGL. DEV. =  10.9 DEGREES          
REMARK 500    PRO B 435   C   -  N   -  CA  ANGL. DEV. =   9.5 DEGREES          
REMARK 500    PRO B 505   C   -  N   -  CA  ANGL. DEV. =   9.9 DEGREES          
REMARK 500    PRO C 435   C   -  N   -  CA  ANGL. DEV. =   9.1 DEGREES          
REMARK 500    PRO C 505   C   -  N   -  CA  ANGL. DEV. =  11.3 DEGREES          
REMARK 500    PRO D 505   C   -  N   -  CA  ANGL. DEV. =  11.1 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    VAL A  17      -84.75    -17.40                                   
REMARK 500    ALA A  18       43.42   -108.04                                   
REMARK 500    VAL A  21      -34.78   -135.01                                   
REMARK 500    LYS A  40     -117.64     31.41                                   
REMARK 500    VAL A 111       -6.46   -149.44                                   
REMARK 500    TYR A 114        6.59    -53.47                                   
REMARK 500    SER A 124       30.20    -99.64                                   
REMARK 500    VAL A 126       -2.26   -141.23                                   
REMARK 500    SER A 130       84.16   -158.10                                   
REMARK 500    GLU A 169      157.14     73.29                                   
REMARK 500    ALA A 194      172.10    159.26                                   
REMARK 500    PHE A 209      -90.56   -134.00                                   
REMARK 500    TYR A 210      -18.30    -46.41                                   
REMARK 500    ASN A 211      -76.49    -83.25                                   
REMARK 500    CYS A 212       21.74    -77.94                                   
REMARK 500    SER A 215       21.54   -146.94                                   
REMARK 500    LYS A 260       40.82     75.70                                   
REMARK 500    PHE A 276      -61.69   -109.72                                   
REMARK 500    CYS A 304       61.74   -160.32                                   
REMARK 500    SER A 345        7.54    -59.44                                   
REMARK 500    ASN A 362       57.41   -112.39                                   
REMARK 500    SER A 363     -158.18     50.95                                   
REMARK 500    PRO A 435      122.55    -31.64                                   
REMARK 500    VAL A 448       59.62    -90.44                                   
REMARK 500    ASP A 449       48.76    146.11                                   
REMARK 500    GLN A 461      -38.21    -39.56                                   
REMARK 500    GLU A 479      138.43   -171.88                                   
REMARK 500    PRO A 505       49.37    -75.45                                   
REMARK 500    GLU A 509       93.73   -167.97                                   
REMARK 500    TRP A 511      -74.73   -133.41                                   
REMARK 500    THR A 527     -169.22   -116.27                                   
REMARK 500    ASP A 539       30.03    -87.55                                   
REMARK 500    GLU A 628     -168.98   -165.10                                   
REMARK 500    VAL B  17      -84.51    -18.03                                   
REMARK 500    ALA B  18       42.87   -108.05                                   
REMARK 500    ASN B  19      113.95   -160.33                                   
REMARK 500    VAL B  21      -35.74   -135.41                                   
REMARK 500    LYS B  40     -115.79     29.99                                   
REMARK 500    VAL B 111       -5.29   -148.05                                   
REMARK 500    TYR B 114        6.60    -55.83                                   
REMARK 500    LEU B 125      -23.90   -140.27                                   
REMARK 500    VAL B 126       -1.87   -141.51                                   
REMARK 500    SER B 130       83.36   -158.12                                   
REMARK 500    GLU B 169      156.48     72.11                                   
REMARK 500    ALA B 194      172.21    158.40                                   
REMARK 500    PHE B 209      -90.98   -132.91                                   
REMARK 500    TYR B 210      -18.69    -45.03                                   
REMARK 500    ASN B 211      -76.09    -83.99                                   
REMARK 500    CYS B 212       21.19    -78.10                                   
REMARK 500    SER B 215       20.86   -147.67                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     126 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR                        
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE                                    
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500    LEU C 285        24.5      L          L   OUTSIDE RANGE           
REMARK 500    LEU D 285        24.4      L          L   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE UDP A 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE UDP B 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE UDP C 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 D 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE UDP D 901                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1RZU   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 2BIS   RELATED DB: PDB                                   
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 AUTHORS SEQUENCE MATCHES WITH GENBANK ENTRY CODE AAA88716. SEE       
REMARK 999 SEQADV REMARK.                                                       
DBREF  3O3C A    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3O3C B    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3O3C C    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3O3C D    1   705  UNP    P27472   GYS2_YEAST       1    705             
SEQADV 3O3C MET A  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY A  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER A  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER A  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS A  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS A  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS A  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS A  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS A  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS A  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER A   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER A   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY A   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C LEU A   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C VAL A   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C PRO A   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C ARG A   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY A   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER A   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS A    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER A  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3O3C ALA A  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3O3C ALA A  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3O3C ALA A  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQADV 3O3C MET B  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY B  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER B  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER B  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS B  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS B  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS B  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS B  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS B  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS B  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER B   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER B   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY B   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C LEU B   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C VAL B   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C PRO B   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C ARG B   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY B   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER B   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS B    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER B  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3O3C ALA B  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3O3C ALA B  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3O3C ALA B  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQADV 3O3C MET C  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY C  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER C  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER C  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS C  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS C  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS C  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS C  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS C  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS C  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER C   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER C   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY C   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C LEU C   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C VAL C   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C PRO C   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C ARG C   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY C   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER C   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS C    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER C  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3O3C ALA C  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3O3C ALA C  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3O3C ALA C  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQADV 3O3C MET D  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY D  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER D  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER D  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS D  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS D  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS D  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS D  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS D  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS D  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER D   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER D   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY D   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C LEU D   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C VAL D   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C PRO D   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C ARG D   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C GLY D   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER D   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C HIS D    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3O3C SER D  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3O3C ALA D  580  UNP  P27472    ARG   580 ENGINEERED MUTATION            
SEQADV 3O3C ALA D  581  UNP  P27472    ARG   581 ENGINEERED MUTATION            
SEQADV 3O3C ALA D  583  UNP  P27472    ARG   583 ENGINEERED MUTATION            
SEQRES   1 A  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 A  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 A  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 A  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 A  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 A  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 A  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 A  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 A  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 A  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 A  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 A  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 A  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 A  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 A  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 A  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 A  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 A  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 A  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 A  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 A  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 A  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 A  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 A  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 A  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 A  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 A  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 A  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 A  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 A  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 A  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 A  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 A  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 A  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 A  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 A  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 A  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 A  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 A  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 A  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 A  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 A  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 A  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 A  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 A  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 A  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 A  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 A  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 A  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 A  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 A  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 A  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 A  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 A  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 A  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 A  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 B  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 B  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 B  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 B  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 B  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 B  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 B  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 B  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 B  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 B  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 B  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 B  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 B  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 B  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 B  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 B  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 B  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 B  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 B  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 B  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 B  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 B  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 B  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 B  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 B  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 B  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 B  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 B  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 B  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 B  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 B  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 B  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 B  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 B  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 B  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 B  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 B  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 B  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 B  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 B  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 B  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 B  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 B  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 B  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 B  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 B  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 B  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 B  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 B  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 B  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 B  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 B  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 B  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 B  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 B  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 B  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 C  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 C  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 C  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 C  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 C  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 C  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 C  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 C  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 C  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 C  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 C  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 C  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 C  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 C  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 C  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 C  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 C  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 C  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 C  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 C  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 C  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 C  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 C  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 C  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 C  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 C  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 C  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 C  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 C  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 C  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 C  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 C  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 C  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 C  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 C  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 C  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 C  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 C  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 C  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 C  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 C  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 C  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 C  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 C  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 C  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 C  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 C  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 C  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 C  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 C  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 C  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 C  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 C  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 C  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 C  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 C  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 D  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 D  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 D  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 D  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 D  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 D  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 D  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 D  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 D  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 D  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 D  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 D  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 D  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 D  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 D  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 D  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 D  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 D  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 D  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 D  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 D  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 D  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 D  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 D  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 D  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 D  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 D  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 D  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 D  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 D  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 D  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 D  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 D  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 D  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 D  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 D  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 D  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 D  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 D  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 D  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 D  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 D  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 D  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 D  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 D  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 D  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 D  725  THR ALA ALA GLN ALA ILE ASN GLN ARG ASN ARG THR GLU          
SEQRES  48 D  725  ARG LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 D  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 D  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 D  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 D  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 D  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 D  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 D  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 D  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
HET    SO4  A 801       5                                                       
HET    SO4  D 802       5                                                       
HET    SO4  A 803       5                                                       
HET    UDP  A 901      25                                                       
HET    SO4  B 801       5                                                       
HET    SO4  C 802       5                                                       
HET    SO4  B 803       5                                                       
HET    UDP  B 901      25                                                       
HET    SO4  C 801       5                                                       
HET    SO4  B 802       5                                                       
HET    SO4  C 803       5                                                       
HET    UDP  C 901      25                                                       
HET    SO4  D 801       5                                                       
HET    SO4  D 803       5                                                       
HET    UDP  D 901      25                                                       
HETNAM     SO4 SULFATE ION                                                      
HETNAM     UDP URIDINE-5'-DIPHOSPHATE                                           
FORMUL   5  SO4    11(O4 S 2-)                                                  
FORMUL   8  UDP    4(C9 H14 N2 O12 P2)                                          
HELIX    1   1 GLY A   23  LYS A   40  1                                  18    
HELIX    2   2 THR A   53  GLU A   57  1                                   5    
HELIX    3   3 LYS A   65  PHE A   69  5                                   5    
HELIX    4   4 MET A   73  ARG A   86  1                                  14    
HELIX    5   5 LEU A  108  GLY A  113  5                                   6    
HELIX    6   6 TYR A  114  GLY A  127  1                                  14    
HELIX    7   7 ASP A  134  ASP A  158  1                                  25    
HELIX    8   8 TRP A  170  GLY A  173  5                                   4    
HELIX    9   9 VAL A  174  ARG A  182  1                                   9    
HELIX   10  10 THR A  195  ALA A  203  1                                   9    
HELIX   11  11 ASN A  211  VAL A  216  5                                   6    
HELIX   12  12 ASP A  217  PHE A  225  1                                   9    
HELIX   13  13 ILE A  227  ALA A  241  1                                  15    
HELIX   14  14 SER A  248  LYS A  260  1                                  13    
HELIX   15  15 ASN A  272  PHE A  276  5                                   5    
HELIX   16  16 LEU A  285  PHE A  301  1                                  17    
HELIX   17  17 ASP A  308  ASP A  310  5                                   3    
HELIX   18  18 GLY A  327  SER A  345  1                                  19    
HELIX   19  19 THR A  365  TYR A  400  1                                  36    
HELIX   20  20 LYS A  418  ALA A  431  1                                  14    
HELIX   21  21 ASP A  453  VAL A  462  1                                  10    
HELIX   22  22 ASP A  491  CYS A  499  1                                   9    
HELIX   23  23 GLY A  512  MET A  521  1                                  10    
HELIX   24  24 SER A  531  ASP A  539  1                                   9    
HELIX   25  25 LEU A  540  LEU A  540  5                                   1    
HELIX   26  26 ALA A  546  TYR A  549  5                                   4    
HELIX   27  27 ALA A  560  LYS A  577  1                                  18    
HELIX   28  28 THR A  579  SER A  594  1                                  16    
HELIX   29  29 ASP A  595  LEU A  597  5                                   3    
HELIX   30  30 ASP A  598  GLY A  603  1                                   6    
HELIX   31  31 GLY A  603  TYR A  618  1                                  16    
HELIX   32  32 TYR A  618  GLY A  627  1                                  10    
HELIX   33  33 ASN A  634  ALA A  639  1                                   6    
HELIX   34  34 GLY B   23  LYS B   40  1                                  18    
HELIX   35  35 THR B   53  GLU B   57  1                                   5    
HELIX   36  36 LYS B   65  PHE B   69  5                                   5    
HELIX   37  37 MET B   73  ARG B   86  1                                  14    
HELIX   38  38 LEU B  108  GLY B  113  5                                   6    
HELIX   39  39 TYR B  114  GLY B  127  1                                  14    
HELIX   40  40 ASP B  134  ASP B  158  1                                  25    
HELIX   41  41 TRP B  170  GLY B  173  5                                   4    
HELIX   42  42 VAL B  174  ARG B  182  1                                   9    
HELIX   43  43 THR B  195  ALA B  203  1                                   9    
HELIX   44  44 ASN B  211  VAL B  216  5                                   6    
HELIX   45  45 ASP B  217  PHE B  225  1                                   9    
HELIX   46  46 ILE B  227  ALA B  241  1                                  15    
HELIX   47  47 SER B  248  LYS B  260  1                                  13    
HELIX   48  48 ASN B  272  PHE B  276  5                                   5    
HELIX   49  49 LEU B  285  PHE B  301  1                                  17    
HELIX   50  50 ASP B  308  ASP B  310  5                                   3    
HELIX   51  51 GLY B  327  SER B  345  1                                  19    
HELIX   52  52 THR B  365  TYR B  400  1                                  36    
HELIX   53  53 LYS B  418  ALA B  431  1                                  14    
HELIX   54  54 ASP B  453  VAL B  462  1                                  10    
HELIX   55  55 ASP B  491  CYS B  499  1                                   9    
HELIX   56  56 GLY B  512  MET B  521  1                                  10    
HELIX   57  57 SER B  531  ASP B  539  1                                   9    
HELIX   58  58 LEU B  540  LEU B  540  5                                   1    
HELIX   59  59 ALA B  546  TYR B  549  5                                   4    
HELIX   60  60 ALA B  560  LYS B  577  1                                  18    
HELIX   61  61 THR B  579  SER B  594  1                                  16    
HELIX   62  62 ASP B  595  LEU B  597  5                                   3    
HELIX   63  63 ASP B  598  GLY B  603  1                                   6    
HELIX   64  64 GLY B  603  TYR B  618  1                                  16    
HELIX   65  65 TYR B  618  GLY B  627  1                                  10    
HELIX   66  66 ASN B  634  ALA B  639  1                                   6    
HELIX   67  67 GLY C   23  LYS C   40  1                                  18    
HELIX   68  68 THR C   53  GLU C   57  1                                   5    
HELIX   69  69 LYS C   65  PHE C   69  5                                   5    
HELIX   70  70 SER C   70  GLU C   72  5                                   3    
HELIX   71  71 MET C   73  ARG C   86  1                                  14    
HELIX   72  72 LEU C  108  GLY C  113  5                                   6    
HELIX   73  73 TYR C  114  GLY C  127  1                                  14    
HELIX   74  74 ASP C  134  ASP C  158  1                                  25    
HELIX   75  75 TRP C  170  GLY C  173  5                                   4    
HELIX   76  76 VAL C  174  ARG C  182  1                                   9    
HELIX   77  77 THR C  195  ALA C  203  1                                   9    
HELIX   78  78 ASN C  211  VAL C  216  5                                   6    
HELIX   79  79 ASP C  217  PHE C  225  1                                   9    
HELIX   80  80 ILE C  227  ALA C  241  1                                  15    
HELIX   81  81 SER C  248  LYS C  260  1                                  13    
HELIX   82  82 ASN C  272  PHE C  276  5                                   5    
HELIX   83  83 LEU C  285  PHE C  301  1                                  17    
HELIX   84  84 ASP C  308  ASP C  310  5                                   3    
HELIX   85  85 GLY C  327  SER C  345  1                                  19    
HELIX   86  86 THR C  365  TYR C  400  1                                  36    
HELIX   87  87 LYS C  418  ALA C  431  1                                  14    
HELIX   88  88 ASP C  453  VAL C  462  1                                  10    
HELIX   89  89 ASP C  491  CYS C  499  1                                   9    
HELIX   90  90 GLY C  512  MET C  521  1                                  10    
HELIX   91  91 SER C  531  ASP C  539  1                                   9    
HELIX   92  92 LEU C  540  LEU C  540  5                                   1    
HELIX   93  93 ALA C  546  TYR C  549  5                                   4    
HELIX   94  94 ALA C  560  LYS C  577  1                                  18    
HELIX   95  95 THR C  579  SER C  594  1                                  16    
HELIX   96  96 ASP C  595  LEU C  597  5                                   3    
HELIX   97  97 ASP C  598  GLY C  603  1                                   6    
HELIX   98  98 GLY C  603  TYR C  618  1                                  16    
HELIX   99  99 TYR C  618  GLY C  627  1                                  10    
HELIX  100 100 ASN C  634  ALA C  639  1                                   6    
HELIX  101 101 GLY D   23  LYS D   40  1                                  18    
HELIX  102 102 THR D   53  GLU D   57  1                                   5    
HELIX  103 103 LYS D   65  PHE D   69  5                                   5    
HELIX  104 104 MET D   73  ARG D   86  1                                  14    
HELIX  105 105 LEU D  108  GLY D  113  5                                   6    
HELIX  106 106 TYR D  114  GLY D  127  1                                  14    
HELIX  107 107 ASP D  134  ASP D  158  1                                  25    
HELIX  108 108 TRP D  170  GLY D  173  5                                   4    
HELIX  109 109 VAL D  174  ARG D  182  1                                   9    
HELIX  110 110 THR D  195  ALA D  203  1                                   9    
HELIX  111 111 ASN D  211  VAL D  216  5                                   6    
HELIX  112 112 ASP D  217  GLY D  226  1                                  10    
HELIX  113 113 ILE D  227  ALA D  241  1                                  15    
HELIX  114 114 SER D  248  LYS D  260  1                                  13    
HELIX  115 115 ASN D  272  PHE D  276  5                                   5    
HELIX  116 116 LEU D  285  PHE D  301  1                                  17    
HELIX  117 117 ASP D  308  ASP D  310  5                                   3    
HELIX  118 118 GLY D  327  SER D  345  1                                  19    
HELIX  119 119 THR D  365  TYR D  400  1                                  36    
HELIX  120 120 LYS D  418  ALA D  431  1                                  14    
HELIX  121 121 ASP D  453  VAL D  462  1                                  10    
HELIX  122 122 ASP D  491  CYS D  499  1                                   9    
HELIX  123 123 GLY D  512  MET D  521  1                                  10    
HELIX  124 124 SER D  531  ASP D  539  1                                   9    
HELIX  125 125 LEU D  540  LEU D  540  5                                   1    
HELIX  126 126 ALA D  546  TYR D  549  5                                   4    
HELIX  127 127 ALA D  560  LYS D  577  1                                  18    
HELIX  128 128 THR D  579  SER D  594  1                                  16    
HELIX  129 129 ASP D  595  LEU D  597  5                                   3    
HELIX  130 130 ASP D  598  GLY D  603  1                                   6    
HELIX  131 131 GLY D  603  TYR D  618  1                                  16    
HELIX  132 132 TYR D  618  GLY D  627  1                                  10    
HELIX  133 133 ASN D  634  ALA D  639  1                                   6    
SHEET    1   A 9 VAL A  58  ILE A  60  0                                        
SHEET    2   A 9 PHE A  90  TRP A  95 -1  O  ARG A  94   N  ASP A  59           
SHEET    3   A 9 LYS A 102  PHE A 106 -1  O  VAL A 103   N  GLY A  93           
SHEET    4   A 9 TYR A  43  PRO A  48  1  N  LEU A  45   O  ILE A 104           
SHEET    5   A 9 ASP A   4  ALA A  14  1  N  GLU A  12   O  ILE A  46           
SHEET    6   A 9 HIS A 161  HIS A 168  1  O  HIS A 166   N  THR A  13           
SHEET    7   A 9 VAL A 187  THR A 192  1  O  ILE A 189   N  PHE A 167           
SHEET    8   A 9 VAL A 243  THR A 246  1  O  THR A 245   N  PHE A 190           
SHEET    9   A 9 GLY A 265  ILE A 266  1  O  GLY A 265   N  THR A 246           
SHEET    1   B 6 VAL A 472  PHE A 476  0                                        
SHEET    2   B 6 THR A 350  VAL A 356  1  N  ALA A 353   O  LYS A 473           
SHEET    3   B 6 THR A 312  ALA A 318  1  N  PHE A 315   O  PHE A 354           
SHEET    4   B 6 LEU A 501  VAL A 503  1  O  VAL A 503   N  PHE A 316           
SHEET    5   B 6 SER A 525  THR A 528  1  O  ILE A 526   N  GLY A 502           
SHEET    6   B 6 ILE A 551  VAL A 554  1  O  VAL A 554   N  THR A 527           
SHEET    1   C 2 ASN A 361  PHE A 364  0                                        
SHEET    2   C 2 HIS A 445  MET A 447 -1  O  ASN A 446   N  SER A 363           
SHEET    1   D 9 VAL B  58  ILE B  60  0                                        
SHEET    2   D 9 PHE B  90  TRP B  95 -1  O  ARG B  94   N  ASP B  59           
SHEET    3   D 9 LYS B 102  PHE B 106 -1  O  VAL B 103   N  GLY B  93           
SHEET    4   D 9 TYR B  43  PRO B  48  1  N  LEU B  45   O  ILE B 104           
SHEET    5   D 9 ASP B   4  ALA B  14  1  N  LEU B  10   O  HIS B  44           
SHEET    6   D 9 HIS B 161  HIS B 168  1  O  HIS B 166   N  THR B  13           
SHEET    7   D 9 VAL B 187  THR B 192  1  O  ILE B 189   N  PHE B 167           
SHEET    8   D 9 VAL B 243  THR B 246  1  O  THR B 245   N  PHE B 190           
SHEET    9   D 9 GLY B 265  ILE B 266  1  O  GLY B 265   N  THR B 246           
SHEET    1   E 6 VAL B 472  PHE B 476  0                                        
SHEET    2   E 6 THR B 350  VAL B 356  1  N  ALA B 353   O  LYS B 473           
SHEET    3   E 6 THR B 312  ALA B 318  1  N  PHE B 315   O  PHE B 354           
SHEET    4   E 6 LEU B 501  VAL B 503  1  O  VAL B 503   N  PHE B 316           
SHEET    5   E 6 SER B 525  THR B 528  1  O  ILE B 526   N  GLY B 502           
SHEET    6   E 6 ILE B 551  VAL B 554  1  O  VAL B 554   N  THR B 527           
SHEET    1   F 2 ASN B 361  PHE B 364  0                                        
SHEET    2   F 2 HIS B 445  MET B 447 -1  O  ASN B 446   N  SER B 363           
SHEET    1   G 9 VAL C  58  ILE C  60  0                                        
SHEET    2   G 9 PHE C  90  TRP C  95 -1  O  ARG C  94   N  ASP C  59           
SHEET    3   G 9 LYS C 102  PHE C 106 -1  O  VAL C 103   N  GLY C  93           
SHEET    4   G 9 TYR C  43  PRO C  48  1  N  LEU C  45   O  ILE C 104           
SHEET    5   G 9 ASP C   4  ALA C  14  1  N  GLU C  12   O  ILE C  46           
SHEET    6   G 9 HIS C 161  HIS C 168  1  O  HIS C 166   N  THR C  13           
SHEET    7   G 9 VAL C 187  THR C 192  1  O  ILE C 189   N  PHE C 167           
SHEET    8   G 9 VAL C 243  THR C 246  1  O  THR C 245   N  PHE C 190           
SHEET    9   G 9 GLY C 265  ILE C 266  1  O  GLY C 265   N  THR C 246           
SHEET    1   H 6 VAL C 472  PHE C 476  0                                        
SHEET    2   H 6 THR C 350  VAL C 356  1  N  ILE C 355   O  ILE C 475           
SHEET    3   H 6 THR C 312  ALA C 318  1  N  PHE C 315   O  PHE C 354           
SHEET    4   H 6 LEU C 501  VAL C 503  1  O  VAL C 503   N  PHE C 316           
SHEET    5   H 6 SER C 525  THR C 528  1  O  ILE C 526   N  GLY C 502           
SHEET    6   H 6 ILE C 551  VAL C 554  1  O  VAL C 554   N  THR C 527           
SHEET    1   I 2 ASN C 361  PHE C 364  0                                        
SHEET    2   I 2 HIS C 445  MET C 447 -1  O  ASN C 446   N  SER C 363           
SHEET    1   J 9 VAL D  58  ILE D  60  0                                        
SHEET    2   J 9 PHE D  90  TRP D  95 -1  O  ARG D  94   N  ASP D  59           
SHEET    3   J 9 LYS D 102  PHE D 106 -1  O  VAL D 103   N  GLY D  93           
SHEET    4   J 9 TYR D  43  PRO D  48  1  N  LEU D  45   O  ILE D 104           
SHEET    5   J 9 ASP D   4  ALA D  14  1  N  GLU D  12   O  ILE D  46           
SHEET    6   J 9 HIS D 161  HIS D 168  1  O  HIS D 166   N  THR D  13           
SHEET    7   J 9 VAL D 187  THR D 192  1  O  ILE D 189   N  PHE D 167           
SHEET    8   J 9 VAL D 243  THR D 246  1  O  THR D 245   N  PHE D 190           
SHEET    9   J 9 GLY D 265  ILE D 266  1  O  GLY D 265   N  THR D 246           
SHEET    1   K 6 VAL D 472  PHE D 476  0                                        
SHEET    2   K 6 THR D 350  VAL D 356  1  N  ILE D 355   O  ILE D 475           
SHEET    3   K 6 THR D 312  ALA D 318  1  N  PHE D 315   O  PHE D 354           
SHEET    4   K 6 LEU D 501  VAL D 503  1  O  VAL D 503   N  PHE D 316           
SHEET    5   K 6 SER D 525  THR D 528  1  O  ILE D 526   N  GLY D 502           
SHEET    6   K 6 ILE D 551  VAL D 554  1  O  VAL D 554   N  THR D 527           
SHEET    1   L 2 ASN D 361  PHE D 364  0                                        
SHEET    2   L 2 HIS D 445  MET D 447 -1  O  ASN D 446   N  ASN D 362           
CISPEP   1 TYR A  400    PRO A  401          0        -3.80                     
CISPEP   2 TYR B  400    PRO B  401          0        -2.23                     
CISPEP   3 TYR C  400    PRO C  401          0         1.84                     
CISPEP   4 TYR D  400    PRO D  401          0        -3.61                     
SITE     1 AC1  5 ARG A  20  TYR A  25  SER A  26  LYS A  29                    
SITE     2 AC1  5 LYS A 275                                                     
SITE     1 AC2  3 ARG A  20  ARG D 427  ARG D 428                               
SITE     1 AC3  3 GLN A 582  ASN A 585  ARG A 589                               
SITE     1 AC4  9 ARG A 320  LYS A 326  PHE A 480  LEU A 481                    
SITE     2 AC4  9 TYR A 492  GLY A 512  TYR A 513  THR A 514                    
SITE     3 AC4  9 GLU A 517                                                     
SITE     1 AC5  3 ARG B  20  SER B  26  LYS B  29                               
SITE     1 AC6  3 ARG B  20  ARG C 427  ARG C 428                               
SITE     1 AC7  2 ASN B 585  ARG B 589                                          
SITE     1 AC8  9 ARG B 320  LYS B 326  PHE B 480  LEU B 481                    
SITE     2 AC8  9 TYR B 492  GLY B 512  TYR B 513  THR B 514                    
SITE     3 AC8  9 GLU B 517                                                     
SITE     1 AC9  3 ARG C  20  SER C  26  LYS C  29                               
SITE     1 BC1  3 ARG B 427  ARG B 428  ARG C  20                               
SITE     1 BC2  2 ASN C 585  ARG C 589                                          
SITE     1 BC3 11 GLY C 319  ARG C 320  LYS C 326  VAL C 356                    
SITE     2 BC3 11 PHE C 480  LEU C 481  TYR C 492  GLY C 512                    
SITE     3 BC3 11 TYR C 513  THR C 514  GLU C 517                               
SITE     1 BC4  4 ARG D  20  SER D  26  LYS D  29  LYS D 275                    
SITE     1 BC5  3 GLN D 582  ASN D 585  ARG D 589                               
SITE     1 BC6  9 ARG D 320  LYS D 326  PHE D 480  LEU D 481                    
SITE     2 BC6  9 TYR D 492  GLY D 512  TYR D 513  THR D 514                    
SITE     3 BC6  9 GLU D 517                                                     
CRYST1   96.586  167.209  121.251  90.00 102.66  90.00 P 1 21 1      8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.010353  0.000000  0.002326        0.00000                         
SCALE2      0.000000  0.005981  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.008453        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system