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Database: PDB
Entry: 3RT1
LinkDB: 3RT1
Original site: 3RT1 
HEADER    TRANSFERASE                             02-MAY-11   3RT1              
TITLE     MALTODEXTARN BOUND ACTIVATED STATE FORM OF YEAST GLYCOGEN SYNTHASE    
TITLE    2 ISOFORM 2                                                            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROTEIN (GLYCOGEN [STARCH] SYNTHASE ISOFORM 2);            
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 EC: 2.4.1.11;                                                        
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BREWER'S YEAST,LAGER BEER YEAST,YEAST;              
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 GENE: GSY2, L8479.8, YLR258W;                                        
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET28A                                    
KEYWDS    MALTODEXTARN BINDING, ROSSMANN FOLD, GLYCOSYL TRANSFERASE, GLYCOGEN   
KEYWDS   2 BINDING, TRANSFERASE                                                 
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    S.BASKARAN,T.D.HURLEY                                                 
REVDAT   2   12-OCT-11 3RT1    1       JRNL                                     
REVDAT   1   10-AUG-11 3RT1    0                                                
JRNL        AUTH   S.BASKARAN,V.M.CHIKWANA,C.J.CONTRERAS,K.D.DAVIS,W.A.WILSON,  
JRNL        AUTH 2 A.A.DEPAOLI-ROACH,P.J.ROACH,T.D.HURLEY                       
JRNL        TITL   MULTIPLE GLYCOGEN-BINDING SITES IN EUKARYOTIC GLYCOGEN       
JRNL        TITL 2 SYNTHASE ARE REQUIRED FOR HIGH CATALYTIC EFFICIENCY TOWARD   
JRNL        TITL 3 GLYCOGEN.                                                    
JRNL        REF    J.BIOL.CHEM.                  V. 286 33999 2011              
JRNL        REFN                   ISSN 0021-9258                               
JRNL        PMID   21835915                                                     
JRNL        DOI    10.1074/JBC.M111.264531                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.80 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE)                               
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.80                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.58                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 0.040                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 95.1                           
REMARK   3   NUMBER OF REFLECTIONS             : 96658                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.213                           
REMARK   3   R VALUE            (WORKING SET) : 0.211                           
REMARK   3   FREE R VALUE                     : 0.261                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 4837                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 48.5865 -  8.6685    0.95     3237   172  0.1670 0.1807        
REMARK   3     2  8.6685 -  6.8867    1.00     3303   162  0.1559 0.2097        
REMARK   3     3  6.8867 -  6.0180    1.00     3256   169  0.1828 0.2210        
REMARK   3     4  6.0180 -  5.4686    1.00     3251   161  0.1862 0.2444        
REMARK   3     5  5.4686 -  5.0770    1.00     3267   147  0.1793 0.2203        
REMARK   3     6  5.0770 -  4.7780    1.00     3225   176  0.1697 0.2383        
REMARK   3     7  4.7780 -  4.5389    1.00     3231   175  0.1651 0.1955        
REMARK   3     8  4.5389 -  4.3414    0.99     3188   171  0.1756 0.2305        
REMARK   3     9  4.3414 -  4.1744    0.99     3188   169  0.1826 0.2484        
REMARK   3    10  4.1744 -  4.0304    0.99     3209   163  0.1858 0.2297        
REMARK   3    11  4.0304 -  3.9045    0.99     3172   183  0.1956 0.2434        
REMARK   3    12  3.9045 -  3.7929    0.99     3143   181  0.2125 0.2660        
REMARK   3    13  3.7929 -  3.6931    0.99     3179   154  0.2084 0.2628        
REMARK   3    14  3.6931 -  3.6030    0.98     3149   166  0.2122 0.2996        
REMARK   3    15  3.6030 -  3.5211    0.98     3117   180  0.2334 0.2773        
REMARK   3    16  3.5211 -  3.4462    0.97     3119   153  0.2346 0.3060        
REMARK   3    17  3.4462 -  3.3773    0.98     3115   173  0.2366 0.2932        
REMARK   3    18  3.3773 -  3.3136    0.96     3059   166  0.2455 0.3270        
REMARK   3    19  3.3136 -  3.2544    0.96     3063   161  0.2552 0.2869        
REMARK   3    20  3.2544 -  3.1993    0.95     3047   164  0.2482 0.3263        
REMARK   3    21  3.1993 -  3.1477    0.94     3004   162  0.2710 0.3135        
REMARK   3    22  3.1477 -  3.0992    0.92     2927   153  0.2705 0.3504        
REMARK   3    23  3.0992 -  3.0537    0.92     2938   170  0.2637 0.2792        
REMARK   3    24  3.0537 -  3.0107    0.91     2888   166  0.2588 0.3514        
REMARK   3    25  3.0107 -  2.9700    0.90     2853   152  0.2801 0.3554        
REMARK   3    26  2.9700 -  2.9314    0.87     2799   143  0.2757 0.3049        
REMARK   3    27  2.9314 -  2.8948    0.87     2790   139  0.2763 0.3337        
REMARK   3    28  2.8948 -  2.8599    0.86     2768   126  0.2732 0.3474        
REMARK   3    29  2.8599 -  2.8266    0.86     2730   134  0.2892 0.3526        
REMARK   3    30  2.8266 -  2.7949    0.82     2606   146  0.2921 0.3467        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : 0.32                                          
REMARK   3   B_SOL              : 31.12                                         
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 2.740            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 27.310           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -4.02680                                             
REMARK   3    B22 (A**2) : 15.39150                                             
REMARK   3    B33 (A**2) : -11.36470                                            
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : -0.00000                                             
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.007          21458                                  
REMARK   3   ANGLE     :  1.012          29100                                  
REMARK   3   CHIRALITY :  0.070           3230                                  
REMARK   3   PLANARITY :  0.004           3720                                  
REMARK   3   DIHEDRAL  : 18.655           7878                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 3RT1 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 03-MAY-11.                  
REMARK 100 THE RCSB ID CODE IS RCSB065340.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : NULL                               
REMARK 200  TEMPERATURE           (KELVIN) : 200                                
REMARK 200  PH                             : 6.2                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 23-ID-D                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0                                
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : NULL                               
REMARK 200  DETECTOR MANUFACTURER          : NULL                               
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 96658                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.800                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.80                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.90                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 4.60                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.50300                            
REMARK 200  R SYM FOR SHELL            (I) : 0.53800                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: MOLREP                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 60.63                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.12                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M BIS-TRIS, 25% PEG 300, VAPOR        
REMARK 280  DIFFUSION, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K, PH 6.2  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: I 2 2 2                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z                                                 
REMARK 290       3555   -X,Y,-Z                                                 
REMARK 290       4555   X,-Y,-Z                                                 
REMARK 290       5555   X+1/2,Y+1/2,Z+1/2                                       
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2                                     
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2                                     
REMARK 290       8555   X+1/2,-Y+1/2,-Z+1/2                                     
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       96.71950            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000      102.66400            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000      103.44450            
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       96.71950            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000      102.66400            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000      103.44450            
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       96.71950            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000      102.66400            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000      103.44450            
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       96.71950            
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000      102.66400            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000      103.44450            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 22200 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 98930 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -23.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, B, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -19                                                      
REMARK 465     GLY A   -18                                                      
REMARK 465     SER A   -17                                                      
REMARK 465     SER A   -16                                                      
REMARK 465     HIS A   -15                                                      
REMARK 465     HIS A   -14                                                      
REMARK 465     HIS A   -13                                                      
REMARK 465     HIS A   -12                                                      
REMARK 465     HIS A   -11                                                      
REMARK 465     HIS A   -10                                                      
REMARK 465     SER A    -9                                                      
REMARK 465     SER A    -8                                                      
REMARK 465     GLY A    -7                                                      
REMARK 465     LEU A    -6                                                      
REMARK 465     VAL A    -5                                                      
REMARK 465     PRO A    -4                                                      
REMARK 465     ARG A    -3                                                      
REMARK 465     GLY A    -2                                                      
REMARK 465     SER A    -1                                                      
REMARK 465     HIS A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     GLY A   640                                                      
REMARK 465     GLY A   641                                                      
REMARK 465     LYS A   642                                                      
REMARK 465     LYS A   643                                                      
REMARK 465     LEU A   644                                                      
REMARK 465     LYS A   645                                                      
REMARK 465     VAL A   646                                                      
REMARK 465     ALA A   647                                                      
REMARK 465     ARG A   648                                                      
REMARK 465     PRO A   649                                                      
REMARK 465     LEU A   650                                                      
REMARK 465     SER A   651                                                      
REMARK 465     VAL A   652                                                      
REMARK 465     PRO A   653                                                      
REMARK 465     GLY A   654                                                      
REMARK 465     SER A   655                                                      
REMARK 465     PRO A   656                                                      
REMARK 465     ARG A   657                                                      
REMARK 465     ASP A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     ARG A   660                                                      
REMARK 465     SER A   661                                                      
REMARK 465     ASN A   662                                                      
REMARK 465     SER A   663                                                      
REMARK 465     THR A   664                                                      
REMARK 465     VAL A   665                                                      
REMARK 465     TYR A   666                                                      
REMARK 465     MET A   667                                                      
REMARK 465     THR A   668                                                      
REMARK 465     PRO A   669                                                      
REMARK 465     GLY A   670                                                      
REMARK 465     ASP A   671                                                      
REMARK 465     LEU A   672                                                      
REMARK 465     GLY A   673                                                      
REMARK 465     THR A   674                                                      
REMARK 465     LEU A   675                                                      
REMARK 465     GLN A   676                                                      
REMARK 465     GLU A   677                                                      
REMARK 465     VAL A   678                                                      
REMARK 465     ASN A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     ALA A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     ASP A   683                                                      
REMARK 465     TYR A   684                                                      
REMARK 465     PHE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     GLY A   688                                                      
REMARK 465     VAL A   689                                                      
REMARK 465     ASN A   690                                                      
REMARK 465     PRO A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     ALA A   693                                                      
REMARK 465     ASP A   694                                                      
REMARK 465     ASP A   695                                                      
REMARK 465     ASP A   696                                                      
REMARK 465     ASP A   697                                                      
REMARK 465     ASP A   698                                                      
REMARK 465     GLY A   699                                                      
REMARK 465     PRO A   700                                                      
REMARK 465     TYR A   701                                                      
REMARK 465     ALA A   702                                                      
REMARK 465     ASP A   703                                                      
REMARK 465     ASP A   704                                                      
REMARK 465     SER A   705                                                      
REMARK 465     MET B   -19                                                      
REMARK 465     GLY B   -18                                                      
REMARK 465     SER B   -17                                                      
REMARK 465     SER B   -16                                                      
REMARK 465     HIS B   -15                                                      
REMARK 465     HIS B   -14                                                      
REMARK 465     HIS B   -13                                                      
REMARK 465     HIS B   -12                                                      
REMARK 465     HIS B   -11                                                      
REMARK 465     HIS B   -10                                                      
REMARK 465     SER B    -9                                                      
REMARK 465     SER B    -8                                                      
REMARK 465     GLY B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     VAL B    -5                                                      
REMARK 465     PRO B    -4                                                      
REMARK 465     ARG B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     SER B    -1                                                      
REMARK 465     HIS B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLY B   640                                                      
REMARK 465     GLY B   641                                                      
REMARK 465     LYS B   642                                                      
REMARK 465     LYS B   643                                                      
REMARK 465     LEU B   644                                                      
REMARK 465     LYS B   645                                                      
REMARK 465     VAL B   646                                                      
REMARK 465     ALA B   647                                                      
REMARK 465     ARG B   648                                                      
REMARK 465     PRO B   649                                                      
REMARK 465     LEU B   650                                                      
REMARK 465     SER B   651                                                      
REMARK 465     VAL B   652                                                      
REMARK 465     PRO B   653                                                      
REMARK 465     GLY B   654                                                      
REMARK 465     SER B   655                                                      
REMARK 465     PRO B   656                                                      
REMARK 465     ARG B   657                                                      
REMARK 465     ASP B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     ARG B   660                                                      
REMARK 465     SER B   661                                                      
REMARK 465     ASN B   662                                                      
REMARK 465     SER B   663                                                      
REMARK 465     THR B   664                                                      
REMARK 465     VAL B   665                                                      
REMARK 465     TYR B   666                                                      
REMARK 465     MET B   667                                                      
REMARK 465     THR B   668                                                      
REMARK 465     PRO B   669                                                      
REMARK 465     GLY B   670                                                      
REMARK 465     ASP B   671                                                      
REMARK 465     LEU B   672                                                      
REMARK 465     GLY B   673                                                      
REMARK 465     THR B   674                                                      
REMARK 465     LEU B   675                                                      
REMARK 465     GLN B   676                                                      
REMARK 465     GLU B   677                                                      
REMARK 465     VAL B   678                                                      
REMARK 465     ASN B   679                                                      
REMARK 465     ASN B   680                                                      
REMARK 465     ALA B   681                                                      
REMARK 465     ASP B   682                                                      
REMARK 465     ASP B   683                                                      
REMARK 465     TYR B   684                                                      
REMARK 465     PHE B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     LEU B   687                                                      
REMARK 465     GLY B   688                                                      
REMARK 465     VAL B   689                                                      
REMARK 465     ASN B   690                                                      
REMARK 465     PRO B   691                                                      
REMARK 465     ALA B   692                                                      
REMARK 465     ALA B   693                                                      
REMARK 465     ASP B   694                                                      
REMARK 465     ASP B   695                                                      
REMARK 465     ASP B   696                                                      
REMARK 465     ASP B   697                                                      
REMARK 465     ASP B   698                                                      
REMARK 465     GLY B   699                                                      
REMARK 465     PRO B   700                                                      
REMARK 465     TYR B   701                                                      
REMARK 465     ALA B   702                                                      
REMARK 465     ASP B   703                                                      
REMARK 465     ASP B   704                                                      
REMARK 465     SER B   705                                                      
REMARK 465     MET C   -19                                                      
REMARK 465     GLY C   -18                                                      
REMARK 465     SER C   -17                                                      
REMARK 465     SER C   -16                                                      
REMARK 465     HIS C   -15                                                      
REMARK 465     HIS C   -14                                                      
REMARK 465     HIS C   -13                                                      
REMARK 465     HIS C   -12                                                      
REMARK 465     HIS C   -11                                                      
REMARK 465     HIS C   -10                                                      
REMARK 465     SER C    -9                                                      
REMARK 465     SER C    -8                                                      
REMARK 465     GLY C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     VAL C    -5                                                      
REMARK 465     PRO C    -4                                                      
REMARK 465     ARG C    -3                                                      
REMARK 465     GLY C    -2                                                      
REMARK 465     SER C    -1                                                      
REMARK 465     HIS C     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ARG C   648                                                      
REMARK 465     PRO C   649                                                      
REMARK 465     LEU C   650                                                      
REMARK 465     SER C   651                                                      
REMARK 465     VAL C   652                                                      
REMARK 465     PRO C   653                                                      
REMARK 465     GLY C   654                                                      
REMARK 465     SER C   655                                                      
REMARK 465     PRO C   656                                                      
REMARK 465     ARG C   657                                                      
REMARK 465     ASP C   658                                                      
REMARK 465     LEU C   659                                                      
REMARK 465     ARG C   660                                                      
REMARK 465     SER C   661                                                      
REMARK 465     ASN C   662                                                      
REMARK 465     SER C   663                                                      
REMARK 465     THR C   664                                                      
REMARK 465     VAL C   665                                                      
REMARK 465     TYR C   666                                                      
REMARK 465     MET C   667                                                      
REMARK 465     THR C   668                                                      
REMARK 465     PRO C   669                                                      
REMARK 465     GLY C   670                                                      
REMARK 465     ASP C   671                                                      
REMARK 465     LEU C   672                                                      
REMARK 465     GLY C   673                                                      
REMARK 465     THR C   674                                                      
REMARK 465     LEU C   675                                                      
REMARK 465     GLN C   676                                                      
REMARK 465     GLU C   677                                                      
REMARK 465     VAL C   678                                                      
REMARK 465     ASN C   679                                                      
REMARK 465     ASN C   680                                                      
REMARK 465     ALA C   681                                                      
REMARK 465     ASP C   682                                                      
REMARK 465     ASP C   683                                                      
REMARK 465     TYR C   684                                                      
REMARK 465     PHE C   685                                                      
REMARK 465     SER C   686                                                      
REMARK 465     LEU C   687                                                      
REMARK 465     GLY C   688                                                      
REMARK 465     VAL C   689                                                      
REMARK 465     ASN C   690                                                      
REMARK 465     PRO C   691                                                      
REMARK 465     ALA C   692                                                      
REMARK 465     ALA C   693                                                      
REMARK 465     ASP C   694                                                      
REMARK 465     ASP C   695                                                      
REMARK 465     ASP C   696                                                      
REMARK 465     ASP C   697                                                      
REMARK 465     ASP C   698                                                      
REMARK 465     GLY C   699                                                      
REMARK 465     PRO C   700                                                      
REMARK 465     TYR C   701                                                      
REMARK 465     ALA C   702                                                      
REMARK 465     ASP C   703                                                      
REMARK 465     ASP C   704                                                      
REMARK 465     SER C   705                                                      
REMARK 465     MET D   -19                                                      
REMARK 465     GLY D   -18                                                      
REMARK 465     SER D   -17                                                      
REMARK 465     SER D   -16                                                      
REMARK 465     HIS D   -15                                                      
REMARK 465     HIS D   -14                                                      
REMARK 465     HIS D   -13                                                      
REMARK 465     HIS D   -12                                                      
REMARK 465     HIS D   -11                                                      
REMARK 465     HIS D   -10                                                      
REMARK 465     SER D    -9                                                      
REMARK 465     SER D    -8                                                      
REMARK 465     GLY D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     VAL D    -5                                                      
REMARK 465     PRO D    -4                                                      
REMARK 465     ARG D    -3                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     SER D    -1                                                      
REMARK 465     HIS D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D   206                                                      
REMARK 465     PHE D   207                                                      
REMARK 465     GLY D   640                                                      
REMARK 465     GLY D   641                                                      
REMARK 465     LYS D   642                                                      
REMARK 465     LYS D   643                                                      
REMARK 465     LEU D   644                                                      
REMARK 465     LYS D   645                                                      
REMARK 465     VAL D   646                                                      
REMARK 465     ALA D   647                                                      
REMARK 465     ARG D   648                                                      
REMARK 465     PRO D   649                                                      
REMARK 465     LEU D   650                                                      
REMARK 465     SER D   651                                                      
REMARK 465     VAL D   652                                                      
REMARK 465     PRO D   653                                                      
REMARK 465     GLY D   654                                                      
REMARK 465     SER D   655                                                      
REMARK 465     PRO D   656                                                      
REMARK 465     ARG D   657                                                      
REMARK 465     ASP D   658                                                      
REMARK 465     LEU D   659                                                      
REMARK 465     ARG D   660                                                      
REMARK 465     SER D   661                                                      
REMARK 465     ASN D   662                                                      
REMARK 465     SER D   663                                                      
REMARK 465     THR D   664                                                      
REMARK 465     VAL D   665                                                      
REMARK 465     TYR D   666                                                      
REMARK 465     MET D   667                                                      
REMARK 465     THR D   668                                                      
REMARK 465     PRO D   669                                                      
REMARK 465     GLY D   670                                                      
REMARK 465     ASP D   671                                                      
REMARK 465     LEU D   672                                                      
REMARK 465     GLY D   673                                                      
REMARK 465     THR D   674                                                      
REMARK 465     LEU D   675                                                      
REMARK 465     GLN D   676                                                      
REMARK 465     GLU D   677                                                      
REMARK 465     VAL D   678                                                      
REMARK 465     ASN D   679                                                      
REMARK 465     ASN D   680                                                      
REMARK 465     ALA D   681                                                      
REMARK 465     ASP D   682                                                      
REMARK 465     ASP D   683                                                      
REMARK 465     TYR D   684                                                      
REMARK 465     PHE D   685                                                      
REMARK 465     SER D   686                                                      
REMARK 465     LEU D   687                                                      
REMARK 465     GLY D   688                                                      
REMARK 465     VAL D   689                                                      
REMARK 465     ASN D   690                                                      
REMARK 465     PRO D   691                                                      
REMARK 465     ALA D   692                                                      
REMARK 465     ALA D   693                                                      
REMARK 465     ASP D   694                                                      
REMARK 465     ASP D   695                                                      
REMARK 465     ASP D   696                                                      
REMARK 465     ASP D   697                                                      
REMARK 465     ASP D   698                                                      
REMARK 465     GLY D   699                                                      
REMARK 465     PRO D   700                                                      
REMARK 465     TYR D   701                                                      
REMARK 465     ALA D   702                                                      
REMARK 465     ASP D   703                                                      
REMARK 465     ASP D   704                                                      
REMARK 465     SER D   705                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO C 435   C   -  N   -  CA  ANGL. DEV. =  10.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  37       37.06    -73.47                                   
REMARK 500    GLN A  38      -12.79   -173.46                                   
REMARK 500    LYS A  40      -94.84     59.26                                   
REMARK 500    THR A  53      -11.72   -148.81                                   
REMARK 500    PRO A  66        0.06    -57.88                                   
REMARK 500    SER A  70     -169.43    -67.47                                   
REMARK 500    VAL A  88       95.75    -69.80                                   
REMARK 500    LEU A  96       72.22    -62.95                                   
REMARK 500    ALA A 100       76.05     24.76                                   
REMARK 500    SER A 110       40.77    -77.27                                   
REMARK 500    VAL A 111      -14.26   -167.71                                   
REMARK 500    ARG A 112      -34.34    -38.09                                   
REMARK 500    TYR A 114        5.08    -62.75                                   
REMARK 500    SER A 115      -72.12    -42.81                                   
REMARK 500    PRO A 129     -178.75    -61.67                                   
REMARK 500    SER A 130       85.03   -177.11                                   
REMARK 500    GLU A 169      149.70     75.37                                   
REMARK 500    ARG A 183       23.58     47.27                                   
REMARK 500    ALA A 194     -170.89   -171.02                                   
REMARK 500    CYS A 304       42.25   -157.21                                   
REMARK 500    ASN A 362       50.90   -109.74                                   
REMARK 500    SER A 363     -171.32     60.01                                   
REMARK 500    PRO A 435      139.17    -38.19                                   
REMARK 500    PRO A 478       40.97    -69.62                                   
REMARK 500    ILE A 487      -53.99   -120.22                                   
REMARK 500    LEU A 488       74.06   -119.27                                   
REMARK 500    GLU A 509       87.43   -158.07                                   
REMARK 500    TRP A 511      -53.59   -125.66                                   
REMARK 500    LYS A 578      151.13    -49.48                                   
REMARK 500    LEU A 625       23.83    -67.20                                   
REMARK 500    VAL A 626      -82.43   -133.28                                   
REMARK 500    ASN A 631      138.30    -31.32                                   
REMARK 500    VAL B  17      -84.51    -72.89                                   
REMARK 500    ALA B  18       55.51   -102.69                                   
REMARK 500    ASN B  19      126.61    178.75                                   
REMARK 500    LYS B  40     -110.84     68.86                                   
REMARK 500    LEU B  96       52.76    -99.31                                   
REMARK 500    ALA B 100       75.18     51.47                                   
REMARK 500    SER B 110        7.81    -69.78                                   
REMARK 500    SER B 130       67.42   -157.62                                   
REMARK 500    GLU B 169      158.33     60.01                                   
REMARK 500    SER B 204      -11.59    176.01                                   
REMARK 500    PHE B 207      169.87    173.92                                   
REMARK 500    PHE B 209      -29.57    -35.84                                   
REMARK 500    SER B 215       45.98    -66.67                                   
REMARK 500    THR B 246     -169.88   -123.94                                   
REMARK 500    ASN B 311       28.88   -152.03                                   
REMARK 500    TYR B 321       95.01    -67.44                                   
REMARK 500    SER B 363     -173.12     73.92                                   
REMARK 500    GLN B 463       45.53     72.03                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     120 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR                        
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE                                    
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500    ASN A 484        20.9      L          L   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     GLC A  800                                                       
REMARK 610     GLC A  810                                                       
REMARK 610     GLC C  804                                                       
REMARK 610     GLC D  805                                                       
REMARK 610     GLC D  810                                                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE G6P A 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 800                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 805                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 806                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 807                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 808                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 809                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC A 810                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG A 1009                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE G6P B 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE G6P B 902                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG B 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE G6P C 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC C 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC C 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC C 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC C 804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG C 1004                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE G6P D 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 805                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 806                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 807                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 808                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 809                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GLC D 810                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PEG B 706                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 3NB0   RELATED DB: PDB                                   
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 AUTHORS SEQUENCE MATCHES WITH GENBANK ENTRY CODE AAA88716. SEE       
REMARK 999 SEQADV REMARK.                                                       
DBREF  3RT1 A    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3RT1 B    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3RT1 C    1   705  UNP    P27472   GYS2_YEAST       1    705             
DBREF  3RT1 D    1   705  UNP    P27472   GYS2_YEAST       1    705             
SEQADV 3RT1 MET A  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY A  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER A  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER A  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS A  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS A  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS A  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS A  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS A  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS A  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER A   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER A   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY A   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 LEU A   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 VAL A   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 PRO A   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 ARG A   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY A   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER A   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS A    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER A  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3RT1 ALA A  589  UNP  P27472    ARG   589 ENGINEERED MUTATION            
SEQADV 3RT1 ALA A  592  UNP  P27472    ARG   592 ENGINEERED MUTATION            
SEQADV 3RT1 MET B  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY B  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER B  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER B  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS B  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS B  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS B  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS B  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS B  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS B  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER B   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER B   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY B   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 LEU B   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 VAL B   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 PRO B   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 ARG B   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY B   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER B   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS B    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER B  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3RT1 ALA B  589  UNP  P27472    ARG   589 ENGINEERED MUTATION            
SEQADV 3RT1 ALA B  592  UNP  P27472    ARG   592 ENGINEERED MUTATION            
SEQADV 3RT1 MET C  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY C  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER C  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER C  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS C  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS C  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS C  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS C  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS C  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS C  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER C   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER C   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY C   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 LEU C   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 VAL C   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 PRO C   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 ARG C   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY C   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER C   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS C    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER C  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3RT1 ALA C  589  UNP  P27472    ARG   589 ENGINEERED MUTATION            
SEQADV 3RT1 ALA C  592  UNP  P27472    ARG   592 ENGINEERED MUTATION            
SEQADV 3RT1 MET D  -19  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY D  -18  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER D  -17  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER D  -16  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS D  -15  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS D  -14  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS D  -13  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS D  -12  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS D  -11  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS D  -10  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER D   -9  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER D   -8  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY D   -7  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 LEU D   -6  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 VAL D   -5  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 PRO D   -4  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 ARG D   -3  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 GLY D   -2  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER D   -1  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 HIS D    0  UNP  P27472              EXPRESSION TAG                 
SEQADV 3RT1 SER D  535  UNP  P27472    ALA   535 SEE REMARK 999                 
SEQADV 3RT1 ALA D  589  UNP  P27472    ARG   589 ENGINEERED MUTATION            
SEQADV 3RT1 ALA D  592  UNP  P27472    ARG   592 ENGINEERED MUTATION            
SEQRES   1 A  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 A  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 A  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 A  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 A  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 A  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 A  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 A  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 A  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 A  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 A  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 A  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 A  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 A  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 A  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 A  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 A  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 A  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 A  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 A  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 A  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 A  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 A  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 A  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 A  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 A  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 A  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 A  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 A  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 A  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 A  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 A  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 A  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 A  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 A  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 A  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 A  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 A  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 A  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 A  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 A  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 A  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 A  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 A  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 A  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 A  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 A  725  THR ARG ARG GLN ARG ILE ASN GLN ARG ASN ALA THR GLU          
SEQRES  48 A  725  ALA LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 A  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 A  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 A  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 A  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 A  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 A  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 A  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 A  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 B  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 B  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 B  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 B  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 B  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 B  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 B  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 B  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 B  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 B  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 B  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 B  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 B  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 B  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 B  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 B  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 B  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 B  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 B  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 B  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 B  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 B  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 B  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 B  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 B  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 B  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 B  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 B  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 B  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 B  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 B  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 B  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 B  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 B  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 B  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 B  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 B  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 B  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 B  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 B  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 B  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 B  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 B  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 B  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 B  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 B  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 B  725  THR ARG ARG GLN ARG ILE ASN GLN ARG ASN ALA THR GLU          
SEQRES  48 B  725  ALA LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 B  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 B  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 B  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 B  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 B  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 B  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 B  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 B  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 C  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 C  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 C  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 C  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 C  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 C  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 C  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 C  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 C  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 C  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 C  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 C  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 C  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 C  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 C  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 C  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 C  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 C  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 C  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 C  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 C  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 C  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 C  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 C  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 C  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 C  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 C  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 C  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 C  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 C  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 C  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 C  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 C  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 C  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 C  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 C  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 C  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 C  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 C  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 C  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 C  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 C  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 C  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 C  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 C  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 C  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 C  725  THR ARG ARG GLN ARG ILE ASN GLN ARG ASN ALA THR GLU          
SEQRES  48 C  725  ALA LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 C  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 C  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 C  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 C  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 C  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 C  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 C  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 C  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
SEQRES   1 D  725  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 D  725  LEU VAL PRO ARG GLY SER HIS MET SER ARG ASP LEU GLN          
SEQRES   3 D  725  ASN HIS LEU LEU PHE GLU THR ALA THR GLU VAL ALA ASN          
SEQRES   4 D  725  ARG VAL GLY GLY ILE TYR SER VAL LEU LYS SER LYS ALA          
SEQRES   5 D  725  PRO ILE THR VAL ALA GLN TYR LYS ASP HIS TYR HIS LEU          
SEQRES   6 D  725  ILE GLY PRO LEU ASN LYS ALA THR TYR GLN ASN GLU VAL          
SEQRES   7 D  725  ASP ILE LEU ASP TRP LYS LYS PRO GLU ALA PHE SER ASP          
SEQRES   8 D  725  GLU MET ARG PRO VAL GLN HIS ALA LEU GLN THR MET GLU          
SEQRES   9 D  725  SER ARG GLY VAL HIS PHE VAL TYR GLY ARG TRP LEU ILE          
SEQRES  10 D  725  GLU GLY ALA PRO LYS VAL ILE LEU PHE ASP LEU ASP SER          
SEQRES  11 D  725  VAL ARG GLY TYR SER ASN GLU TRP LYS GLY ASP LEU TRP          
SEQRES  12 D  725  SER LEU VAL GLY ILE PRO SER PRO GLU ASN ASP PHE GLU          
SEQRES  13 D  725  THR ASN ASP ALA ILE LEU LEU GLY TYR THR VAL ALA TRP          
SEQRES  14 D  725  PHE LEU GLY GLU VAL ALA HIS LEU ASP SER GLN HIS ALA          
SEQRES  15 D  725  ILE VAL ALA HIS PHE HIS GLU TRP LEU ALA GLY VAL ALA          
SEQRES  16 D  725  LEU PRO LEU CYS ARG LYS ARG ARG ILE ASP VAL VAL THR          
SEQRES  17 D  725  ILE PHE THR THR HIS ALA THR LEU LEU GLY ARG TYR LEU          
SEQRES  18 D  725  CYS ALA SER GLY SER PHE ASP PHE TYR ASN CYS LEU GLU          
SEQRES  19 D  725  SER VAL ASP VAL ASP HIS GLU ALA GLY ARG PHE GLY ILE          
SEQRES  20 D  725  TYR HIS ARG TYR CYS ILE GLU ARG ALA ALA ALA HIS SER          
SEQRES  21 D  725  ALA ASP VAL PHE THR THR VAL SER GLN ILE THR ALA PHE          
SEQRES  22 D  725  GLU ALA GLU HIS LEU LEU LYS ARG LYS PRO ASP GLY ILE          
SEQRES  23 D  725  LEU PRO ASN GLY LEU ASN VAL ILE LYS PHE GLN ALA PHE          
SEQRES  24 D  725  HIS GLU PHE GLN ASN LEU HIS ALA LEU LYS LYS GLU LYS          
SEQRES  25 D  725  ILE ASN ASP PHE VAL ARG GLY HIS PHE HIS GLY CYS PHE          
SEQRES  26 D  725  ASP PHE ASP LEU ASP ASN THR LEU TYR PHE PHE ILE ALA          
SEQRES  27 D  725  GLY ARG TYR GLU TYR LYS ASN LYS GLY ALA ASP MET PHE          
SEQRES  28 D  725  ILE GLU ALA LEU ALA ARG LEU ASN TYR ARG LEU LYS VAL          
SEQRES  29 D  725  SER GLY SER LYS LYS THR VAL VAL ALA PHE ILE VAL MET          
SEQRES  30 D  725  PRO ALA LYS ASN ASN SER PHE THR VAL GLU ALA LEU LYS          
SEQRES  31 D  725  GLY GLN ALA GLU VAL ARG ALA LEU GLU ASN THR VAL HIS          
SEQRES  32 D  725  GLU VAL THR THR SER ILE GLY LYS ARG ILE PHE ASP HIS          
SEQRES  33 D  725  ALA ILE ARG TYR PRO HIS ASN GLY LEU THR THR GLU LEU          
SEQRES  34 D  725  PRO THR ASP LEU GLY GLU LEU LEU LYS SER SER ASP LYS          
SEQRES  35 D  725  VAL MET LEU LYS ARG ARG ILE LEU ALA LEU ARG ARG PRO          
SEQRES  36 D  725  GLU GLY GLN LEU PRO PRO ILE VAL THR HIS ASN MET VAL          
SEQRES  37 D  725  ASP ASP ALA ASN ASP LEU ILE LEU ASN LYS ILE ARG GLN          
SEQRES  38 D  725  VAL GLN LEU PHE ASN SER PRO SER ASP ARG VAL LYS MET          
SEQRES  39 D  725  ILE PHE HIS PRO GLU PHE LEU ASN ALA ASN ASN PRO ILE          
SEQRES  40 D  725  LEU GLY LEU ASP TYR ASP GLU PHE VAL ARG GLY CYS HIS          
SEQRES  41 D  725  LEU GLY VAL PHE PRO SER TYR TYR GLU PRO TRP GLY TYR          
SEQRES  42 D  725  THR PRO ALA GLU CYS THR VAL MET GLY VAL PRO SER ILE          
SEQRES  43 D  725  THR THR ASN VAL SER GLY PHE GLY SER TYR MET GLU ASP          
SEQRES  44 D  725  LEU ILE GLU THR ASN GLN ALA LYS ASP TYR GLY ILE TYR          
SEQRES  45 D  725  ILE VAL ASP ARG ARG PHE LYS ALA PRO ASP GLU SER VAL          
SEQRES  46 D  725  GLU GLN LEU VAL ASP TYR MET GLU GLU PHE VAL LYS LYS          
SEQRES  47 D  725  THR ARG ARG GLN ARG ILE ASN GLN ARG ASN ALA THR GLU          
SEQRES  48 D  725  ALA LEU SER ASP LEU LEU ASP TRP LYS ARG MET GLY LEU          
SEQRES  49 D  725  GLU TYR VAL LYS ALA ARG GLN LEU ALA LEU ARG ARG GLY          
SEQRES  50 D  725  TYR PRO ASP GLN PHE ARG GLU LEU VAL GLY GLU GLU LEU          
SEQRES  51 D  725  ASN ASP SER ASN MET ASP ALA LEU ALA GLY GLY LYS LYS          
SEQRES  52 D  725  LEU LYS VAL ALA ARG PRO LEU SER VAL PRO GLY SER PRO          
SEQRES  53 D  725  ARG ASP LEU ARG SER ASN SER THR VAL TYR MET THR PRO          
SEQRES  54 D  725  GLY ASP LEU GLY THR LEU GLN GLU VAL ASN ASN ALA ASP          
SEQRES  55 D  725  ASP TYR PHE SER LEU GLY VAL ASN PRO ALA ALA ASP ASP          
SEQRES  56 D  725  ASP ASP ASP GLY PRO TYR ALA ASP ASP SER                      
HET    G6P  A 901      16                                                       
HET    GLC  A 800       1                                                       
HET    GLC  A 801      11                                                       
HET    GLC  A 802      11                                                       
HET    GLC  A 803      11                                                       
HET    GLC  A 804      11                                                       
HET    GLC  A 805      11                                                       
HET    GLC  A 806      11                                                       
HET    GLC  A 807      11                                                       
HET    GLC  A 808      11                                                       
HET    GLC  A 809      11                                                       
HET    GLC  A 810       1                                                       
HET    PEG  A1009       7                                                       
HET    G6P  B 901      16                                                       
HET    G6P  B 902      16                                                       
HET    PEG  B1001       7                                                       
HET    G6P  C 901      16                                                       
HET    GLC  C 801      11                                                       
HET    GLC  C 802      11                                                       
HET    GLC  C 803      11                                                       
HET    GLC  C 804       1                                                       
HET    PEG  C1004       7                                                       
HET    G6P  D 901      16                                                       
HET    GLC  D 801      11                                                       
HET    GLC  D 802      11                                                       
HET    GLC  D 803      11                                                       
HET    GLC  D 804      11                                                       
HET    GLC  D 805       1                                                       
HET    GLC  D 806      11                                                       
HET    GLC  D 807      11                                                       
HET    GLC  D 808      11                                                       
HET    GLC  D 809      11                                                       
HET    GLC  D 810       1                                                       
HET    PEG  B 706       7                                                       
HETNAM     G6P ALPHA-D-GLUCOSE-6-PHOSPHATE                                      
HETNAM     GLC ALPHA-D-GLUCOSE                                                  
HETNAM     PEG DI(HYDROXYETHYL)ETHER                                            
FORMUL   5  G6P    5(C6 H13 O9 P)                                               
FORMUL   6  GLC    25(C6 H12 O6)                                                
FORMUL   8  PEG    4(C4 H10 O3)                                                 
HELIX    1   1 GLY A   22  LYS A   40  1                                  19    
HELIX    2   2 THR A   53  GLU A   57  1                                   5    
HELIX    3   3 MET A   73  GLY A   87  1                                  15    
HELIX    4   4 LEU A  108  GLY A  113  5                                   6    
HELIX    5   5 TYR A  114  VAL A  126  1                                  13    
HELIX    6   6 ASP A  134  ASP A  158  1                                  25    
HELIX    7   7 TRP A  170  GLY A  173  5                                   4    
HELIX    8   8 VAL A  174  ARG A  182  1                                   9    
HELIX    9   9 THR A  195  CYS A  202  1                                   8    
HELIX   10  10 ASP A  208  LEU A  213  1                                   6    
HELIX   11  11 GLU A  214  VAL A  216  5                                   3    
HELIX   12  12 ASP A  217  PHE A  225  1                                   9    
HELIX   13  13 ILE A  227  ALA A  241  1                                  15    
HELIX   14  14 SER A  248  LEU A  259  1                                  12    
HELIX   15  15 HIS A  280  PHE A  301  1                                  22    
HELIX   16  16 ASP A  308  ASP A  310  5                                   3    
HELIX   17  17 GLY A  327  SER A  345  1                                  19    
HELIX   18  18 THR A  365  TYR A  400  1                                  36    
HELIX   19  19 ASP A  412  LEU A  416  5                                   5    
HELIX   20  20 LYS A  418  ARG A  433  1                                  16    
HELIX   21  21 ASP A  449  ASN A  452  5                                   4    
HELIX   22  22 ASP A  453  VAL A  462  1                                  10    
HELIX   23  23 ASP A  491  CYS A  499  1                                   9    
HELIX   24  24 GLY A  512  MET A  521  1                                  10    
HELIX   25  25 SER A  531  ASP A  539  1                                   9    
HELIX   26  26 GLU A  542  LYS A  547  1                                   6    
HELIX   27  27 ALA A  560  LYS A  578  1                                  19    
HELIX   28  28 THR A  579  SER A  594  1                                  16    
HELIX   29  29 ASP A  595  LEU A  597  5                                   3    
HELIX   30  30 ASP A  598  GLN A  611  1                                  14    
HELIX   31  31 LEU A  612  TYR A  618  1                                   7    
HELIX   32  32 TYR A  618  LEU A  625  1                                   8    
HELIX   33  33 GLY B   23  LYS B   31  1                                   9    
HELIX   34  34 LYS B   31  LYS B   40  1                                  10    
HELIX   35  35 LYS B   65  PHE B   69  5                                   5    
HELIX   36  36 MET B   73  ARG B   86  1                                  14    
HELIX   37  37 VAL B  111  GLY B  113  5                                   3    
HELIX   38  38 TYR B  114  SER B  124  1                                  11    
HELIX   39  39 ASP B  134  ASP B  158  1                                  25    
HELIX   40  40 GLU B  169  GLY B  173  1                                   5    
HELIX   41  41 VAL B  174  ARG B  182  1                                   9    
HELIX   42  42 THR B  195  ALA B  203  1                                   9    
HELIX   43  43 ALA B  222  GLY B  226  5                                   5    
HELIX   44  44 ILE B  227  ALA B  241  1                                  15    
HELIX   45  45 SER B  248  LYS B  260  1                                  13    
HELIX   46  46 HIS B  280  PHE B  301  1                                  22    
HELIX   47  47 ASP B  308  ASP B  310  5                                   3    
HELIX   48  48 GLY B  327  SER B  345  1                                  19    
HELIX   49  49 THR B  365  TYR B  400  1                                  36    
HELIX   50  50 ASP B  412  LEU B  417  1                                   6    
HELIX   51  51 LYS B  418  LEU B  432  1                                  15    
HELIX   52  52 ASP B  453  GLN B  463  1                                  11    
HELIX   53  53 ASP B  491  CYS B  499  1                                   9    
HELIX   54  54 GLY B  512  MET B  521  1                                  10    
HELIX   55  55 SER B  531  ASP B  539  1                                   9    
HELIX   56  56 GLU B  542  LYS B  547  1                                   6    
HELIX   57  57 ALA B  560  LYS B  577  1                                  18    
HELIX   58  58 THR B  579  LEU B  593  1                                  15    
HELIX   59  59 SER B  594  LEU B  597  5                                   4    
HELIX   60  60 ASP B  598  TYR B  618  1                                  21    
HELIX   61  61 TYR B  618  GLY B  627  1                                  10    
HELIX   62  62 GLY C   22  LYS C   40  1                                  19    
HELIX   63  63 THR C   53  GLU C   57  1                                   5    
HELIX   64  64 LYS C   65  PHE C   69  5                                   5    
HELIX   65  65 MET C   73  ARG C   86  1                                  14    
HELIX   66  66 ASP C  107  ARG C  112  5                                   6    
HELIX   67  67 TYR C  114  SER C  124  1                                  11    
HELIX   68  68 ASP C  134  ASP C  158  1                                  25    
HELIX   69  69 VAL C  174  ARG C  182  1                                   9    
HELIX   70  70 THR C  195  SER C  204  1                                  10    
HELIX   71  71 ASP C  217  GLY C  226  1                                  10    
HELIX   72  72 ILE C  227  ALA C  241  1                                  15    
HELIX   73  73 SER C  248  LYS C  260  1                                  13    
HELIX   74  74 HIS C  280  PHE C  301  1                                  22    
HELIX   75  75 ASP C  308  ASP C  310  5                                   3    
HELIX   76  76 GLY C  327  GLY C  346  1                                  20    
HELIX   77  77 THR C  365  TYR C  400  1                                  36    
HELIX   78  78 ASP C  412  LEU C  416  5                                   5    
HELIX   79  79 LYS C  418  ALA C  431  1                                  14    
HELIX   80  80 ASP C  453  GLN C  463  1                                  11    
HELIX   81  81 ASP C  491  CYS C  499  1                                   9    
HELIX   82  82 GLY C  512  VAL C  520  1                                   9    
HELIX   83  83 SER C  531  ILE C  541  1                                  11    
HELIX   84  84 GLU C  542  TYR C  549  5                                   8    
HELIX   85  85 ALA C  560  LYS C  577  1                                  18    
HELIX   86  86 THR C  579  SER C  594  1                                  16    
HELIX   87  87 ASP C  595  LEU C  597  5                                   3    
HELIX   88  88 ASP C  598  TYR C  618  1                                  21    
HELIX   89  89 TYR C  618  GLY C  627  1                                  10    
HELIX   90  90 ASN C  634  GLY C  640  1                                   7    
HELIX   91  91 GLY D   22  LYS D   40  1                                  19    
HELIX   92  92 THR D   53  VAL D   58  1                                   6    
HELIX   93  93 MET D   73  SER D   85  1                                  13    
HELIX   94  94 LEU D  108  GLY D  113  5                                   6    
HELIX   95  95 TYR D  114  SER D  124  1                                  11    
HELIX   96  96 ASP D  134  LEU D  157  1                                  24    
HELIX   97  97 TRP D  170  GLY D  173  5                                   4    
HELIX   98  98 VAL D  174  ARG D  182  1                                   9    
HELIX   99  99 THR D  195  CYS D  202  1                                   8    
HELIX  100 100 ASP D  217  GLY D  226  1                                  10    
HELIX  101 101 ILE D  227  ALA D  241  1                                  15    
HELIX  102 102 SER D  248  LYS D  260  1                                  13    
HELIX  103 103 HIS D  280  PHE D  301  1                                  22    
HELIX  104 104 ASP D  308  ASP D  310  5                                   3    
HELIX  105 105 GLY D  327  SER D  345  1                                  19    
HELIX  106 106 THR D  365  TYR D  400  1                                  36    
HELIX  107 107 ASP D  412  LEU D  416  5                                   5    
HELIX  108 108 LYS D  418  ARG D  433  1                                  16    
HELIX  109 109 ASP D  453  VAL D  462  1                                  10    
HELIX  110 110 ASP D  491  GLY D  498  1                                   8    
HELIX  111 111 GLY D  512  MET D  521  1                                  10    
HELIX  112 112 SER D  531  ASP D  539  1                                   9    
HELIX  113 113 GLN D  545  TYR D  549  5                                   5    
HELIX  114 114 ALA D  560  LYS D  578  1                                  19    
HELIX  115 115 THR D  579  SER D  594  1                                  16    
HELIX  116 116 ASP D  595  LEU D  597  5                                   3    
HELIX  117 117 ASP D  598  GLY D  603  1                                   6    
HELIX  118 118 LEU D  604  LEU D  612  1                                   9    
SHEET    1   A 9 VAL A  58  ILE A  60  0                                        
SHEET    2   A 9 PHE A  90  TRP A  95 -1  O  ARG A  94   N  ASP A  59           
SHEET    3   A 9 LYS A 102  PHE A 106 -1  O  LEU A 105   N  VAL A  91           
SHEET    4   A 9 TYR A  43  PRO A  48  1  N  GLY A  47   O  PHE A 106           
SHEET    5   A 9 LEU A  10  ALA A  14  1  N  GLU A  12   O  HIS A  44           
SHEET    6   A 9 VAL A 164  HIS A 168  1  O  HIS A 166   N  THR A  13           
SHEET    7   A 9 VAL A 187  THR A 192  1  O  THR A 191   N  PHE A 167           
SHEET    8   A 9 VAL A 243  THR A 246  1  O  THR A 245   N  THR A 192           
SHEET    9   A 9 GLY A 265  ILE A 266  1  O  GLY A 265   N  THR A 246           
SHEET    1   B 6 VAL A 472  PHE A 476  0                                        
SHEET    2   B 6 THR A 350  VAL A 356  1  N  VAL A 351   O  LYS A 473           
SHEET    3   B 6 THR A 312  ALA A 318  1  N  LEU A 313   O  VAL A 352           
SHEET    4   B 6 LEU A 501  VAL A 503  1  O  VAL A 503   N  PHE A 316           
SHEET    5   B 6 SER A 525  THR A 528  1  O  ILE A 526   N  GLY A 502           
SHEET    6   B 6 ILE A 551  VAL A 554  1  O  VAL A 554   N  THR A 527           
SHEET    1   C 2 ASN A 361  PHE A 364  0                                        
SHEET    2   C 2 HIS A 445  MET A 447 -1  O  ASN A 446   N  ASN A 362           
SHEET    1   D 8 VAL B  58  ILE B  60  0                                        
SHEET    2   D 8 PHE B  90  TRP B  95 -1  O  ARG B  94   N  ASP B  59           
SHEET    3   D 8 LYS B 102  PHE B 106 -1  O  LEU B 105   N  VAL B  91           
SHEET    4   D 8 TYR B  43  PRO B  48  1  N  GLY B  47   O  PHE B 106           
SHEET    5   D 8 ASP B   4  THR B  13  1  N  LEU B  10   O  HIS B  44           
SHEET    6   D 8 HIS B 161  HIS B 168  1  O  HIS B 168   N  THR B  13           
SHEET    7   D 8 VAL B 187  THR B 192  1  O  VAL B 187   N  ALA B 165           
SHEET    8   D 8 VAL B 243  THR B 246  1  O  THR B 245   N  PHE B 190           
SHEET    1   E 6 VAL B 472  PHE B 476  0                                        
SHEET    2   E 6 THR B 350  VAL B 356  1  N  VAL B 351   O  LYS B 473           
SHEET    3   E 6 THR B 312  ALA B 318  1  N  PHE B 315   O  PHE B 354           
SHEET    4   E 6 LEU B 501  VAL B 503  1  O  VAL B 503   N  PHE B 316           
SHEET    5   E 6 SER B 525  THR B 528  1  O  ILE B 526   N  GLY B 502           
SHEET    6   E 6 ILE B 551  VAL B 554  1  O  TYR B 552   N  THR B 527           
SHEET    1   F 2 ASN B 361  PHE B 364  0                                        
SHEET    2   F 2 HIS B 445  MET B 447 -1  O  ASN B 446   N  ASN B 362           
SHEET    1   G 9 VAL C  58  ILE C  60  0                                        
SHEET    2   G 9 GLY C  93  TRP C  95 -1  O  ARG C  94   N  ASP C  59           
SHEET    3   G 9 LYS C 102  PHE C 106 -1  O  VAL C 103   N  GLY C  93           
SHEET    4   G 9 TYR C  43  PRO C  48  1  N  LEU C  45   O  ILE C 104           
SHEET    5   G 9 ASP C   4  THR C  13  1  N  GLU C  12   O  HIS C  44           
SHEET    6   G 9 HIS C 161  HIS C 168  1  O  ALA C 162   N  LEU C   9           
SHEET    7   G 9 VAL C 187  THR C 192  1  O  THR C 191   N  PHE C 167           
SHEET    8   G 9 VAL C 243  THR C 246  1  O  THR C 245   N  PHE C 190           
SHEET    9   G 9 GLY C 265  ILE C 266  1  O  GLY C 265   N  THR C 246           
SHEET    1   H 6 VAL C 472  PHE C 476  0                                        
SHEET    2   H 6 THR C 350  VAL C 356  1  N  ALA C 353   O  ILE C 475           
SHEET    3   H 6 THR C 312  ALA C 318  1  N  ILE C 317   O  VAL C 356           
SHEET    4   H 6 LEU C 501  PHE C 504  1  O  VAL C 503   N  PHE C 316           
SHEET    5   H 6 SER C 525  THR C 528  1  O  ILE C 526   N  PHE C 504           
SHEET    6   H 6 ILE C 551  VAL C 554  1  O  VAL C 554   N  THR C 527           
SHEET    1   I 2 ASN C 361  PHE C 364  0                                        
SHEET    2   I 2 HIS C 445  MET C 447 -1  O  ASN C 446   N  ASN C 362           
SHEET    1   J 7 PHE D  90  ARG D  94  0                                        
SHEET    2   J 7 LYS D 102  PHE D 106 -1  O  LEU D 105   N  VAL D  91           
SHEET    3   J 7 TYR D  43  PRO D  48  1  N  LEU D  45   O  LYS D 102           
SHEET    4   J 7 ASP D   4  ALA D  14  1  N  GLU D  12   O  ILE D  46           
SHEET    5   J 7 HIS D 161  HIS D 168  1  O  HIS D 166   N  PHE D  11           
SHEET    6   J 7 VAL D 187  THR D 192  1  O  VAL D 187   N  ILE D 163           
SHEET    7   J 7 VAL D 243  THR D 246  1  O  THR D 245   N  PHE D 190           
SHEET    1   K 6 VAL D 472  PHE D 476  0                                        
SHEET    2   K 6 THR D 350  VAL D 356  1  N  VAL D 351   O  LYS D 473           
SHEET    3   K 6 THR D 312  ALA D 318  1  N  LEU D 313   O  THR D 350           
SHEET    4   K 6 LEU D 501  VAL D 503  1  O  VAL D 503   N  PHE D 316           
SHEET    5   K 6 SER D 525  THR D 528  1  O  ILE D 526   N  GLY D 502           
SHEET    6   K 6 ILE D 551  VAL D 554  1  O  VAL D 554   N  THR D 527           
SHEET    1   L 2 ASN D 361  PHE D 364  0                                        
SHEET    2   L 2 HIS D 445  MET D 447 -1  O  ASN D 446   N  SER D 363           
LINK         O4  GLC A 800                 C1  GLC A 801     1555   1555  1.47  
LINK         O4  GLC A 801                 C1  GLC A 802     1555   1555  1.45  
LINK         O4  GLC A 802                 C1  GLC A 803     1555   1555  1.44  
LINK         O4  GLC A 803                 C1  GLC A 804     1555   1555  1.44  
LINK         O4  GLC A 804                 C1  GLC A 805     1555   1555  1.43  
LINK         O4  GLC A 805                 C1  GLC A 806     1555   1555  1.45  
LINK         O4  GLC A 806                 C1  GLC A 807     1555   1555  1.45  
LINK         C1  GLC A 808                 O4  GLC A 809     1555   1555  1.43  
LINK         C1  GLC A 809                 O4  GLC A 810     1555   1555  1.44  
LINK         C1  GLC C 801                 O4  GLC C 802     1555   1555  1.44  
LINK         C1  GLC C 802                 O4  GLC C 803     1555   1555  1.42  
LINK         C1  GLC C 803                 O4  GLC C 804     1555   1555  1.44  
LINK         C1  GLC D 801                 O4  GLC D 802     1555   1555  1.44  
LINK         C1  GLC D 802                 O4  GLC D 803     1555   1555  1.43  
LINK         C1  GLC D 803                 O4  GLC D 804     1555   1555  1.44  
LINK         C1  GLC D 804                 O4  GLC D 805     1555   1555  1.46  
LINK         C1  GLC D 806                 O4  GLC D 807     1555   1555  1.44  
LINK         C1  GLC D 807                 O4  GLC D 808     1555   1555  1.43  
LINK         C1  GLC D 808                 O4  GLC D 809     1555   1555  1.43  
LINK         C1  GLC D 809                 O4  GLC D 810     1555   1555  1.45  
CISPEP   1 TYR A  400    PRO A  401          0         8.11                     
CISPEP   2 TYR B  400    PRO B  401          0         2.44                     
CISPEP   3 TYR C  400    PRO C  401          0         5.12                     
CISPEP   4 TYR D  400    PRO D  401          0         7.34                     
SITE     1 AC1 10 GLN A 283  ASN A 284  HIS A 286  ALA A 287                    
SITE     2 AC1 10 LYS A 290  HIS A 500  ARG A 580  ARG A 583                    
SITE     3 AC1 10 ARG A 587  HIS B 280                                          
SITE     1 AC2  1 GLC A 801                                                     
SITE     1 AC3  5 ASP A 329  MET A 330  PRO A 561  GLC A 800                    
SITE     2 AC3  5 GLC A 802                                                     
SITE     1 AC4  4 LYS A 324  ARG A 556  GLC A 801  GLC A 803                    
SITE     1 AC5  6 ASP A 208  ASN A 211  ARG A 557  LYS A 559                    
SITE     2 AC5  6 GLC A 802  GLC A 804                                          
SITE     1 AC6  3 PHE A 558  GLC A 803  GLC A 805                               
SITE     1 AC7  4 PHE A 558  GLU A 563  GLC A 804  GLC A 806                    
SITE     1 AC8  3 LYS A 559  GLC A 805  GLC A 807                               
SITE     1 AC9  4 ASN A 529  GLU A 538  ASP A 555  GLC A 806                    
SITE     1 BC1  2 ARG A 337  GLC A 809                                          
SITE     1 BC2  5 GLU A 333  GLN A 461  VAL A 462  GLC A 808                    
SITE     2 BC2  5 GLC A 810                                                     
SITE     1 BC3  1 GLC A 809                                                     
SITE     1 BC4  3 LYS A 391  PHE A 394  HIS C 383                               
SITE     1 BC5  9 HIS A 280  GLN B 283  ASN B 284  HIS B 286                    
SITE     2 BC5  9 LYS B 290  HIS B 500  ARG B 580  ARG B 583                    
SITE     3 BC5  9 ARG B 587                                                     
SITE     1 BC6  7 GLY B  23  GLU B 169  HIS B 193  ARG B 199                    
SITE     2 BC6  7 ARG B 320  LYS B 326  TYR B 513                               
SITE     1 BC7  3 LYS B 391  PHE B 394  GLU D 379                               
SITE     1 BC8  9 GLN C 283  ASN C 284  HIS C 286  LYS C 290                    
SITE     2 BC8  9 HIS C 500  ARG C 580  ARG C 583  ARG C 587                    
SITE     3 BC8  9 HIS D 280                                                     
SITE     1 BC9  4 GLY C 152  GLU C 153  HIS C 156  GLC C 802                    
SITE     1 CC1  6 ALA C 148  TRP C 149  GLY C 152  ARG C 182                    
SITE     2 CC1  6 GLC C 801  GLC C 803                                          
SITE     1 CC2  6 GLU C 117  TRP C 118  ASP C 121  ARG C 182                    
SITE     2 CC2  6 GLC C 802  GLC C 804                                          
SITE     1 CC3  1 GLC C 803                                                     
SITE     1 CC4  3 ARG A 298  LYS C 391  PHE C 394                               
SITE     1 CC5  8 HIS C 280  GLN D 283  HIS D 286  LYS D 290                    
SITE     2 CC5  8 HIS D 500  ARG D 580  ARG D 583  ARG D 587                    
SITE     1 CC6  2 GLY D 437  GLC D 802                                          
SITE     1 CC7  4 LEU D 439  PHE D 465  GLC D 801  GLC D 803                    
SITE     1 CC8  7 PRO D 441  ILE D 442  VAL D 443  ASP D 450                    
SITE     2 CC8  7 ARG D 460  GLC D 802  GLC D 804                               
SITE     1 CC9  6 HIS D 445  ASN D 446  MET D 447  ASP D 450                    
SITE     2 CC9  6 GLC D 803  GLC D 805                                          
SITE     1 DC1  2 ASN D 446  GLC D 804                                          
SITE     1 DC2  2 TYR D 340  GLC D 807                                          
SITE     1 DC3  4 ARG D 337  TYR D 340  GLC D 806  GLC D 808                    
SITE     1 DC4  5 GLU D 333  ARG D 337  VAL D 462  GLC D 807                    
SITE     2 DC4  5 GLC D 809                                                     
SITE     1 DC5  3 GLN D 461  GLC D 808  GLC D 810                               
SITE     1 DC6  1 GLC D 809                                                     
SITE     1 DC7  3 GLU B 291  HIS B 383  PHE D 394                               
CRYST1  193.439  205.328  206.889  90.00  90.00  90.00 I 2 2 2      32          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005170  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.004870  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.004834        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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