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Database: PDB
Entry: 4ADF
LinkDB: 4ADF
Original site: 4ADF 
HEADER    IMMUNE SYSTEM/RECEPTOR                  23-DEC-11   4ADF              
TITLE     CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (HCSF-1)   
TITLE    2 CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: SECRETED PROTEIN BARF1;                                    
COMPND   3 CHAIN: A, B, C, D, E, F, M, N, O, P, Q, R;                           
COMPND   4 SYNONYM: BARF1,33 KDA EARLY PROTEIN, P33;                            
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MUTATION: YES;                                                       
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: MACROPHAGE COLONY-STIMULATING FACTOR 1;                    
COMPND   9 CHAIN: G, H, I, J, K, L, S, T, U, V, W, X;                           
COMPND  10 FRAGMENT: UNP RESIDUES 33-181;                                       
COMPND  11 SYNONYM: HCSF-1, CSF-1, M-CSF, MCSF, LANIMOSTIM, PROCESSED MACROPHAGE
COMPND  12 COLONY-STIMULATING FACTOR 1;                                         
COMPND  13 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HUMAN HERPESVIRUS 4;                            
SOURCE   3 ORGANISM_TAXID: 10376;                                               
SOURCE   4 STRAIN: B95-8;                                                       
SOURCE   5 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   6 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 EXPRESSION_SYSTEM_CELL_LINE: HEK293T;                                
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_VECTOR: PHLSEC;                                    
SOURCE  11 MOL_ID: 2;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  13 ORGANISM_COMMON: HUMAN;                                              
SOURCE  14 ORGANISM_TAXID: 9606;                                                
SOURCE  15 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  17 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE  18 EXPRESSION_SYSTEM_VARIANT: CODONPLUS RIL;                            
SOURCE  19 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  20 EXPRESSION_SYSTEM_VECTOR: PET15B                                     
KEYWDS    IMMUNE SYSTEM-RECEPTOR COMPLEX, RTKIII, EXTRACELLULAR, CYTOKINE       
KEYWDS   2 RECEPTOR-CYTOKINE COMPLEX, FOUR-HELIX BUNDLE, GLYCOPROTEIN,          
KEYWDS   3 IMMUNOGLOBULIN DOMAIN, ONCOGENE, CYTOKINE/SIGNALING                  
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    J.ELEGHEERT,N.BRACKE,S.N.SAVVIDES                                     
REVDAT   4   20-DEC-23 4ADF    1       HETSYN                                   
REVDAT   3   29-JUL-20 4ADF    1       COMPND REMARK HETNAM LINK                
REVDAT   3 2                   1       SITE   ATOM                              
REVDAT   2   26-SEP-12 4ADF    1       JRNL                                     
REVDAT   1   22-AUG-12 4ADF    0                                                
JRNL        AUTH   J.ELEGHEERT,N.BRACKE,P.POULIOT,I.GUTSCHE,A.V.SHKUMATOV,      
JRNL        AUTH 2 N.TARBOURIECH,K.VERSTRAETE,A.BEKAERT,W.P.BURMEISTER,         
JRNL        AUTH 3 D.I.SVERGUN,B.N.LAMBRECHT,B.VERGAUWEN,S.N.SAVVIDES           
JRNL        TITL   ALLOSTERIC COMPETITIVE INACTIVATION OF HEMATOPOIETIC CSF-1   
JRNL        TITL 2 SIGNALING BY THE VIRAL DECOY RECEPTOR BARF1.                 
JRNL        REF    NAT.STRUCT.MOL.BIOL.          V.  19   938 2012              
JRNL        REFN                   ISSN 1545-9993                               
JRNL        PMID   22902366                                                     
JRNL        DOI    10.1038/NSMB.2367                                            
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE)                               
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 4.40                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 75.85                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.1                           
REMARK   3   NUMBER OF REFLECTIONS             : 58094                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.240                           
REMARK   3   R VALUE            (WORKING SET) : 0.238                           
REMARK   3   FREE R VALUE                     : 0.276                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2872                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 75.8580 - 12.1236    0.97     2786   113  0.2939 0.2882        
REMARK   3     2 12.1236 -  9.6290    0.98     2676   141  0.1934 0.2242        
REMARK   3     3  9.6290 -  8.4137    0.99     2663   140  0.1973 0.2268        
REMARK   3     4  8.4137 -  7.6452    0.99     2649   140  0.2101 0.2506        
REMARK   3     5  7.6452 -  7.0976    1.00     2648   139  0.1939 0.2606        
REMARK   3     6  7.0976 -  6.6794    0.99     2654   138  0.2103 0.2731        
REMARK   3     7  6.6794 -  6.3451    0.99     2648   138  0.2195 0.2555        
REMARK   3     8  6.3451 -  6.0690    0.99     2610   137  0.2233 0.2878        
REMARK   3     9  6.0690 -  5.8355    1.00     2638   139  0.2207 0.2694        
REMARK   3    10  5.8355 -  5.6342    0.99     2637   138  0.2288 0.3082        
REMARK   3    11  5.6342 -  5.4581    0.99     2594   136  0.2341 0.3028        
REMARK   3    12  5.4581 -  5.3021    0.99     2618   139  0.2249 0.3184        
REMARK   3    13  5.3021 -  5.1625    0.99     2605   136  0.2282 0.2806        
REMARK   3    14  5.1625 -  5.0366    1.00     2628   139  0.2356 0.2904        
REMARK   3    15  5.0366 -  4.9221    0.99     2627   138  0.2493 0.3138        
REMARK   3    16  4.9221 -  4.8174    1.00     2614   138  0.2693 0.3190        
REMARK   3    17  4.8174 -  4.7210    0.99     2563   137  0.2814 0.2884        
REMARK   3    18  4.7210 -  4.6320    0.99     2631   139  0.2830 0.2995        
REMARK   3    19  4.6320 -  4.5493    0.99     2564   136  0.3078 0.3401        
REMARK   3    20  4.5493 -  4.4722    0.99     2604   137  0.3222 0.3562        
REMARK   3    21  4.4722 -  4.4000    0.97     2565   134  0.3456 0.4054        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.30                                          
REMARK   3   SHRINKAGE RADIUS   : 1.11                                          
REMARK   3   K_SOL              : 0.32                                          
REMARK   3   B_SOL              : 187.2                                         
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.450            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 27.500           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 165.8                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 216.8                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 19.42460                                             
REMARK   3    B22 (A**2) : 19.42460                                             
REMARK   3    B33 (A**2) : -38.84930                                            
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.006          33275                                  
REMARK   3   ANGLE     :  1.292          45139                                  
REMARK   3   CHIRALITY :  0.070           5276                                  
REMARK   3   PLANARITY :  0.005           5606                                  
REMARK   3   DIHEDRAL  : 21.617          12385                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4ADF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 23-DEC-11.                  
REMARK 100 THE DEPOSITION ID IS D_1290050791.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 11-DEC-09                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 8.50                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SLS                                
REMARK 200  BEAMLINE                       : X06DA                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9714                             
REMARK 200  MONOCHROMATOR                  : BARTELS                            
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 225 MM CCD               
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 58151                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 4.400                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 75.850                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.4                               
REMARK 200  DATA REDUNDANCY                : 5.600                              
REMARK 200  R MERGE                    (I) : 0.12000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 13.5000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 4.40                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 4.51                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.2                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.60                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.81000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.800                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB ENTRIES 2CH8, 3UF2                               
REMARK 200                                                                      
REMARK 200 REMARK: NONE                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 74.10                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.60                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M TRIS HCL, PH 8.50, 1.0 M           
REMARK 280  AMMONIUM PHOSPHATE MONOBASIC                                        
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 31 2 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+1/3                                            
REMARK 290       3555   -X+Y,-X,Z+2/3                                           
REMARK 290       4555   Y,X,-Z                                                  
REMARK 290       5555   X-Y,-Y,-Z+2/3                                           
REMARK 290       6555   -X,-X+Y,-Z+1/3                                          
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      110.39000            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      220.78000            
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000      220.78000            
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000      110.39000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC                
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 35730 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 93500 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -10.5 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, Y, Z, a, b, c, d                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC                
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 36350 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 94650 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -1.5 KCAL/MOL                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: M, N, O, P, Q, R, S, T, U, V,         
REMARK 350                    AND CHAINS: W, X, e, f, g, h, i, j                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 400                                                                      
REMARK 400 COMPOUND                                                             
REMARK 400 ENGINEERED RESIDUE IN CHAIN A, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN B, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN C, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN D, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN E, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN F, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN M, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN N, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN O, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN P, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN Q, THR 169 TO SER                        
REMARK 400 ENGINEERED RESIDUE IN CHAIN R, THR 169 TO SER                        
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     PRO A   161                                                      
REMARK 465     GLU A   162                                                      
REMARK 465     GLY A   163                                                      
REMARK 465     VAL A   164                                                      
REMARK 465     GLU A   165                                                      
REMARK 465     PRO A   166                                                      
REMARK 465     ALA A   167                                                      
REMARK 465     PRO A   168                                                      
REMARK 465     SER A   169                                                      
REMARK 465     ALA A   170                                                      
REMARK 465     ALA A   171                                                      
REMARK 465     SER A   220                                                      
REMARK 465     GLN A   221                                                      
REMARK 465     LYS A   222                                                      
REMARK 465     HIS A   223                                                      
REMARK 465     HIS A   224                                                      
REMARK 465     HIS A   225                                                      
REMARK 465     HIS A   226                                                      
REMARK 465     HIS A   227                                                      
REMARK 465     HIS A   228                                                      
REMARK 465     GLU B   162                                                      
REMARK 465     GLY B   163                                                      
REMARK 465     VAL B   164                                                      
REMARK 465     GLU B   165                                                      
REMARK 465     PRO B   166                                                      
REMARK 465     ALA B   167                                                      
REMARK 465     PRO B   168                                                      
REMARK 465     SER B   169                                                      
REMARK 465     ALA B   170                                                      
REMARK 465     ALA B   171                                                      
REMARK 465     ASN B   172                                                      
REMARK 465     GLN B   221                                                      
REMARK 465     LYS B   222                                                      
REMARK 465     HIS B   223                                                      
REMARK 465     HIS B   224                                                      
REMARK 465     HIS B   225                                                      
REMARK 465     HIS B   226                                                      
REMARK 465     HIS B   227                                                      
REMARK 465     HIS B   228                                                      
REMARK 465     PRO C   161                                                      
REMARK 465     GLU C   162                                                      
REMARK 465     GLY C   163                                                      
REMARK 465     VAL C   164                                                      
REMARK 465     GLU C   165                                                      
REMARK 465     PRO C   166                                                      
REMARK 465     ALA C   167                                                      
REMARK 465     PRO C   168                                                      
REMARK 465     SER C   169                                                      
REMARK 465     ALA C   170                                                      
REMARK 465     ALA C   171                                                      
REMARK 465     ASN C   172                                                      
REMARK 465     LEU C   219                                                      
REMARK 465     SER C   220                                                      
REMARK 465     GLN C   221                                                      
REMARK 465     LYS C   222                                                      
REMARK 465     HIS C   223                                                      
REMARK 465     HIS C   224                                                      
REMARK 465     HIS C   225                                                      
REMARK 465     HIS C   226                                                      
REMARK 465     HIS C   227                                                      
REMARK 465     HIS C   228                                                      
REMARK 465     PRO D   161                                                      
REMARK 465     GLU D   162                                                      
REMARK 465     GLY D   163                                                      
REMARK 465     VAL D   164                                                      
REMARK 465     GLU D   165                                                      
REMARK 465     PRO D   166                                                      
REMARK 465     ALA D   167                                                      
REMARK 465     PRO D   168                                                      
REMARK 465     SER D   169                                                      
REMARK 465     ALA D   170                                                      
REMARK 465     ALA D   171                                                      
REMARK 465     ASN D   172                                                      
REMARK 465     GLY D   173                                                      
REMARK 465     GLN D   221                                                      
REMARK 465     LYS D   222                                                      
REMARK 465     HIS D   223                                                      
REMARK 465     HIS D   224                                                      
REMARK 465     HIS D   225                                                      
REMARK 465     HIS D   226                                                      
REMARK 465     HIS D   227                                                      
REMARK 465     HIS D   228                                                      
REMARK 465     PRO E   161                                                      
REMARK 465     GLU E   162                                                      
REMARK 465     GLY E   163                                                      
REMARK 465     VAL E   164                                                      
REMARK 465     GLU E   165                                                      
REMARK 465     PRO E   166                                                      
REMARK 465     ALA E   167                                                      
REMARK 465     PRO E   168                                                      
REMARK 465     SER E   169                                                      
REMARK 465     ALA E   170                                                      
REMARK 465     ALA E   171                                                      
REMARK 465     ASN E   172                                                      
REMARK 465     SER E   220                                                      
REMARK 465     GLN E   221                                                      
REMARK 465     LYS E   222                                                      
REMARK 465     HIS E   223                                                      
REMARK 465     HIS E   224                                                      
REMARK 465     HIS E   225                                                      
REMARK 465     HIS E   226                                                      
REMARK 465     HIS E   227                                                      
REMARK 465     HIS E   228                                                      
REMARK 465     PRO F   161                                                      
REMARK 465     GLU F   162                                                      
REMARK 465     GLY F   163                                                      
REMARK 465     VAL F   164                                                      
REMARK 465     GLU F   165                                                      
REMARK 465     PRO F   166                                                      
REMARK 465     ALA F   167                                                      
REMARK 465     PRO F   168                                                      
REMARK 465     SER F   169                                                      
REMARK 465     ALA F   170                                                      
REMARK 465     SER F   220                                                      
REMARK 465     GLN F   221                                                      
REMARK 465     LYS F   222                                                      
REMARK 465     HIS F   223                                                      
REMARK 465     HIS F   224                                                      
REMARK 465     HIS F   225                                                      
REMARK 465     HIS F   226                                                      
REMARK 465     HIS F   227                                                      
REMARK 465     HIS F   228                                                      
REMARK 465     GLY G    -3                                                      
REMARK 465     SER G    -2                                                      
REMARK 465     HIS G    -1                                                      
REMARK 465     MET G     0                                                      
REMARK 465     GLU G     1                                                      
REMARK 465     GLU G     2                                                      
REMARK 465     SER G   148                                                      
REMARK 465     GLN G   149                                                      
REMARK 465     GLY H    -3                                                      
REMARK 465     SER H    -2                                                      
REMARK 465     HIS H    -1                                                      
REMARK 465     MET H     0                                                      
REMARK 465     GLU H     1                                                      
REMARK 465     GLU H     2                                                      
REMARK 465     VAL H     3                                                      
REMARK 465     SER H     4                                                      
REMARK 465     GLU H     5                                                      
REMARK 465     SER H   148                                                      
REMARK 465     GLN H   149                                                      
REMARK 465     GLY I    -3                                                      
REMARK 465     SER I    -2                                                      
REMARK 465     HIS I    -1                                                      
REMARK 465     MET I     0                                                      
REMARK 465     GLU I     1                                                      
REMARK 465     GLU I     2                                                      
REMARK 465     VAL I     3                                                      
REMARK 465     SER I     4                                                      
REMARK 465     GLU I     5                                                      
REMARK 465     TYR I     6                                                      
REMARK 465     TYR I    95                                                      
REMARK 465     GLU I    96                                                      
REMARK 465     GLU I    97                                                      
REMARK 465     HIS I    98                                                      
REMARK 465     SER I   148                                                      
REMARK 465     GLN I   149                                                      
REMARK 465     GLY J    -3                                                      
REMARK 465     SER J    -2                                                      
REMARK 465     HIS J    -1                                                      
REMARK 465     MET J     0                                                      
REMARK 465     GLU J     1                                                      
REMARK 465     GLU J     2                                                      
REMARK 465     VAL J     3                                                      
REMARK 465     SER J     4                                                      
REMARK 465     GLU J     5                                                      
REMARK 465     SER J   148                                                      
REMARK 465     GLN J   149                                                      
REMARK 465     GLY K    -3                                                      
REMARK 465     SER K    -2                                                      
REMARK 465     HIS K    -1                                                      
REMARK 465     MET K     0                                                      
REMARK 465     GLU K     1                                                      
REMARK 465     GLU K     2                                                      
REMARK 465     VAL K     3                                                      
REMARK 465     SER K   147                                                      
REMARK 465     SER K   148                                                      
REMARK 465     GLN K   149                                                      
REMARK 465     GLY L    -3                                                      
REMARK 465     SER L    -2                                                      
REMARK 465     HIS L    -1                                                      
REMARK 465     MET L     0                                                      
REMARK 465     GLU L     1                                                      
REMARK 465     GLU L     2                                                      
REMARK 465     VAL L     3                                                      
REMARK 465     SER L     4                                                      
REMARK 465     GLU L     5                                                      
REMARK 465     TYR L     6                                                      
REMARK 465     THR L    92                                                      
REMARK 465     LYS L    93                                                      
REMARK 465     ASP L    94                                                      
REMARK 465     TYR L    95                                                      
REMARK 465     GLU L    96                                                      
REMARK 465     SER L   147                                                      
REMARK 465     SER L   148                                                      
REMARK 465     GLN L   149                                                      
REMARK 465     GLU M   162                                                      
REMARK 465     GLY M   163                                                      
REMARK 465     VAL M   164                                                      
REMARK 465     GLU M   165                                                      
REMARK 465     PRO M   166                                                      
REMARK 465     ALA M   167                                                      
REMARK 465     PRO M   168                                                      
REMARK 465     SER M   169                                                      
REMARK 465     SER M   220                                                      
REMARK 465     GLN M   221                                                      
REMARK 465     LYS M   222                                                      
REMARK 465     HIS M   223                                                      
REMARK 465     HIS M   224                                                      
REMARK 465     HIS M   225                                                      
REMARK 465     HIS M   226                                                      
REMARK 465     HIS M   227                                                      
REMARK 465     HIS M   228                                                      
REMARK 465     VAL N   164                                                      
REMARK 465     GLU N   165                                                      
REMARK 465     PRO N   166                                                      
REMARK 465     ALA N   167                                                      
REMARK 465     PRO N   168                                                      
REMARK 465     SER N   169                                                      
REMARK 465     ALA N   170                                                      
REMARK 465     ALA N   171                                                      
REMARK 465     SER N   220                                                      
REMARK 465     GLN N   221                                                      
REMARK 465     LYS N   222                                                      
REMARK 465     HIS N   223                                                      
REMARK 465     HIS N   224                                                      
REMARK 465     HIS N   225                                                      
REMARK 465     HIS N   226                                                      
REMARK 465     HIS N   227                                                      
REMARK 465     HIS N   228                                                      
REMARK 465     GLU O   162                                                      
REMARK 465     GLY O   163                                                      
REMARK 465     VAL O   164                                                      
REMARK 465     GLU O   165                                                      
REMARK 465     PRO O   166                                                      
REMARK 465     ALA O   167                                                      
REMARK 465     PRO O   168                                                      
REMARK 465     SER O   169                                                      
REMARK 465     ALA O   170                                                      
REMARK 465     ALA O   171                                                      
REMARK 465     ASN O   172                                                      
REMARK 465     GLY O   173                                                      
REMARK 465     GLY O   174                                                      
REMARK 465     SER O   220                                                      
REMARK 465     GLN O   221                                                      
REMARK 465     LYS O   222                                                      
REMARK 465     HIS O   223                                                      
REMARK 465     HIS O   224                                                      
REMARK 465     HIS O   225                                                      
REMARK 465     HIS O   226                                                      
REMARK 465     HIS O   227                                                      
REMARK 465     HIS O   228                                                      
REMARK 465     GLU P   162                                                      
REMARK 465     GLY P   163                                                      
REMARK 465     VAL P   164                                                      
REMARK 465     GLU P   165                                                      
REMARK 465     PRO P   166                                                      
REMARK 465     ALA P   167                                                      
REMARK 465     PRO P   168                                                      
REMARK 465     SER P   169                                                      
REMARK 465     ALA P   170                                                      
REMARK 465     ALA P   171                                                      
REMARK 465     ASN P   172                                                      
REMARK 465     GLN P   221                                                      
REMARK 465     LYS P   222                                                      
REMARK 465     HIS P   223                                                      
REMARK 465     HIS P   224                                                      
REMARK 465     HIS P   225                                                      
REMARK 465     HIS P   226                                                      
REMARK 465     HIS P   227                                                      
REMARK 465     HIS P   228                                                      
REMARK 465     PRO Q   161                                                      
REMARK 465     GLU Q   162                                                      
REMARK 465     GLY Q   163                                                      
REMARK 465     VAL Q   164                                                      
REMARK 465     GLU Q   165                                                      
REMARK 465     PRO Q   166                                                      
REMARK 465     ALA Q   167                                                      
REMARK 465     PRO Q   168                                                      
REMARK 465     SER Q   169                                                      
REMARK 465     ALA Q   170                                                      
REMARK 465     ALA Q   171                                                      
REMARK 465     ASN Q   172                                                      
REMARK 465     GLY Q   173                                                      
REMARK 465     GLY Q   174                                                      
REMARK 465     SER Q   220                                                      
REMARK 465     GLN Q   221                                                      
REMARK 465     LYS Q   222                                                      
REMARK 465     HIS Q   223                                                      
REMARK 465     HIS Q   224                                                      
REMARK 465     HIS Q   225                                                      
REMARK 465     HIS Q   226                                                      
REMARK 465     HIS Q   227                                                      
REMARK 465     HIS Q   228                                                      
REMARK 465     PRO R   161                                                      
REMARK 465     GLU R   162                                                      
REMARK 465     GLY R   163                                                      
REMARK 465     VAL R   164                                                      
REMARK 465     GLU R   165                                                      
REMARK 465     PRO R   166                                                      
REMARK 465     ALA R   167                                                      
REMARK 465     PRO R   168                                                      
REMARK 465     SER R   169                                                      
REMARK 465     ALA R   170                                                      
REMARK 465     ALA R   171                                                      
REMARK 465     ASN R   172                                                      
REMARK 465     GLY R   173                                                      
REMARK 465     GLY R   174                                                      
REMARK 465     GLN R   221                                                      
REMARK 465     LYS R   222                                                      
REMARK 465     HIS R   223                                                      
REMARK 465     HIS R   224                                                      
REMARK 465     HIS R   225                                                      
REMARK 465     HIS R   226                                                      
REMARK 465     HIS R   227                                                      
REMARK 465     HIS R   228                                                      
REMARK 465     GLY S    -3                                                      
REMARK 465     SER S    -2                                                      
REMARK 465     HIS S    -1                                                      
REMARK 465     MET S     0                                                      
REMARK 465     GLU S     1                                                      
REMARK 465     GLU S     2                                                      
REMARK 465     VAL S     3                                                      
REMARK 465     SER S   148                                                      
REMARK 465     GLN S   149                                                      
REMARK 465     GLY T    -3                                                      
REMARK 465     SER T    -2                                                      
REMARK 465     HIS T    -1                                                      
REMARK 465     MET T     0                                                      
REMARK 465     GLU T     1                                                      
REMARK 465     GLU T     2                                                      
REMARK 465     VAL T     3                                                      
REMARK 465     SER T     4                                                      
REMARK 465     GLU T     5                                                      
REMARK 465     SER T   148                                                      
REMARK 465     GLN T   149                                                      
REMARK 465     GLY U    -3                                                      
REMARK 465     SER U    -2                                                      
REMARK 465     HIS U    -1                                                      
REMARK 465     MET U     0                                                      
REMARK 465     GLU U     1                                                      
REMARK 465     GLU U     2                                                      
REMARK 465     VAL U     3                                                      
REMARK 465     SER U   148                                                      
REMARK 465     GLN U   149                                                      
REMARK 465     GLY V    -3                                                      
REMARK 465     SER V    -2                                                      
REMARK 465     HIS V    -1                                                      
REMARK 465     MET V     0                                                      
REMARK 465     GLU V     1                                                      
REMARK 465     GLU V     2                                                      
REMARK 465     VAL V     3                                                      
REMARK 465     SER V     4                                                      
REMARK 465     TYR V    95                                                      
REMARK 465     GLU V    96                                                      
REMARK 465     SER V   148                                                      
REMARK 465     GLN V   149                                                      
REMARK 465     GLY W    -3                                                      
REMARK 465     SER W    -2                                                      
REMARK 465     HIS W    -1                                                      
REMARK 465     MET W     0                                                      
REMARK 465     GLU W     1                                                      
REMARK 465     GLU W     2                                                      
REMARK 465     ASP W    94                                                      
REMARK 465     TYR W    95                                                      
REMARK 465     GLU W    96                                                      
REMARK 465     SER W   148                                                      
REMARK 465     GLN W   149                                                      
REMARK 465     GLY X    -3                                                      
REMARK 465     SER X    -2                                                      
REMARK 465     HIS X    -1                                                      
REMARK 465     MET X     0                                                      
REMARK 465     GLU X     1                                                      
REMARK 465     GLU X     2                                                      
REMARK 465     VAL X     3                                                      
REMARK 465     ASP X    94                                                      
REMARK 465     TYR X    95                                                      
REMARK 465     GLU X    96                                                      
REMARK 465     GLU X    97                                                      
REMARK 465     HIS X    98                                                      
REMARK 465     SER X   148                                                      
REMARK 465     GLN X   149                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ASN A 172    CG   OD1  ND2                                       
REMARK 470     LYS B 179    CG   CD   CE   NZ                                   
REMARK 470     LYS D 179    CG   CD   CE   NZ                                   
REMARK 470     LYS E 179    CG   CD   CE   NZ                                   
REMARK 470     ASN F 172    CG   OD1  ND2                                       
REMARK 470     LYS F 193    CG   CD   CE   NZ                                   
REMARK 470     GLU G   5    CG   CD   OE1  OE2                                  
REMARK 470     TYR G  95    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     HIS G  98    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS G 100    CG   CD   CE   NZ                                   
REMARK 470     LYS G 130    CG   CD   CE   NZ                                   
REMARK 470     GLN H  42    CG   CD   OE1  NE2                                  
REMARK 470     TYR H  95    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN H 140    CG   OD1  ND2                                       
REMARK 470     GLU H 145    CG   CD   OE1  OE2                                  
REMARK 470     LYS I  44    CG   CD   CE   NZ                                   
REMARK 470     ARG I  68    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 130    CG   CD   CE   NZ                                   
REMARK 470     TYR J  95    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS J 130    CG   CD   CE   NZ                                   
REMARK 470     ASN J 140    CG   OD1  ND2                                       
REMARK 470     LYS K  93    CG   CD   CE   NZ                                   
REMARK 470     TYR K  95    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS K 130    CG   CD   CE   NZ                                   
REMARK 470     LYS L 130    CG   CD   CE   NZ                                   
REMARK 470     LYS L 137    CG   CD   CE   NZ                                   
REMARK 470     ASN L 140    CG   OD1  ND2                                       
REMARK 470     ASN M 172    CG   OD1  ND2                                       
REMARK 470     LYS M 207    CG   CD   CE   NZ                                   
REMARK 470     LYS O 179    CG   CD   CE   NZ                                   
REMARK 470     LYS O 193    CG   CD   CE   NZ                                   
REMARK 470     LYS O 207    CG   CD   CE   NZ                                   
REMARK 470     LYS R 179    CG   CD   CE   NZ                                   
REMARK 470     LYS S  93    CG   CD   CE   NZ                                   
REMARK 470     HIS S  98    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS S 100    CG   CD   CE   NZ                                   
REMARK 470     LYS S 130    CG   CD   CE   NZ                                   
REMARK 470     LYS S 137    CG   CD   CE   NZ                                   
REMARK 470     TYR T  95    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     HIS T  98    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN T 140    CG   OD1  ND2                                       
REMARK 470     LYS U  51    CG   CD   CE   NZ                                   
REMARK 470     TYR U  95    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU U  97    CG   CD   OE1  OE2                                  
REMARK 470     LYS U 130    CG   CD   CE   NZ                                   
REMARK 470     GLU V   5    CG   CD   OE1  OE2                                  
REMARK 470     ASN V 140    CG   OD1  ND2                                       
REMARK 470     GLU V 145    CG   CD   OE1  OE2                                  
REMARK 470     LYS W  44    CG   CD   CE   NZ                                   
REMARK 470     LYS W  51    CG   CD   CE   NZ                                   
REMARK 470     GLU W  97    CG   CD   OE1  OE2                                  
REMARK 470     HIS W  98    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP W  99    CG   OD1  OD2                                       
REMARK 470     LYS W 100    CG   CD   CE   NZ                                   
REMARK 470     LYS W 130    CG   CD   CE   NZ                                   
REMARK 470     ARG X  86    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS X 100    CG   CD   CE   NZ                                   
REMARK 470     LYS X 130    CG   CD   CE   NZ                                   
REMARK 470     ASN X 140    CG   OD1  ND2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    MET A 160   CA  -  CB  -  CG  ANGL. DEV. =  15.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  84     -136.33     55.73                                   
REMARK 500    GLU A 117      118.22   -161.96                                   
REMARK 500    ASP A 206     -124.96     59.71                                   
REMARK 500    ALA B  84     -136.48     55.67                                   
REMARK 500    GLU B 117      118.70   -162.43                                   
REMARK 500    ASP B 206     -125.11     59.50                                   
REMARK 500    ALA C  84     -136.26     55.78                                   
REMARK 500    GLU C 117      118.53   -162.77                                   
REMARK 500    ASP C 206     -125.53     59.62                                   
REMARK 500    ALA D  84     -136.26     55.77                                   
REMARK 500    GLU D 117      119.14   -162.41                                   
REMARK 500    ASP D 206     -125.25     59.81                                   
REMARK 500    ALA E  84     -136.17     56.02                                   
REMARK 500    GLU E 117      118.64   -162.73                                   
REMARK 500    ASP E 206     -125.19     59.56                                   
REMARK 500    ALA F  84     -136.37     55.81                                   
REMARK 500    GLU F 117      118.75   -162.45                                   
REMARK 500    ASP F 206     -124.93     59.50                                   
REMARK 500    TYR G   6       17.12     83.03                                   
REMARK 500    THR G  64      -70.82   -107.94                                   
REMARK 500    CYS G 146      -85.80    -85.15                                   
REMARK 500    THR H  64      -71.09   -107.95                                   
REMARK 500    THR I  64      -70.85   -108.08                                   
REMARK 500    CYS I 146      -82.98    -82.20                                   
REMARK 500    THR J  64      -70.87   -108.00                                   
REMARK 500    THR K  64      -70.66   -107.45                                   
REMARK 500    THR L  64      -70.78   -108.19                                   
REMARK 500    ALA M  84     -136.20     55.61                                   
REMARK 500    GLU M 117      118.53   -162.45                                   
REMARK 500    ASN M 172       68.93   -109.97                                   
REMARK 500    ASP M 206     -125.18     59.64                                   
REMARK 500    ALA N  84     -136.72     55.96                                   
REMARK 500    GLU N 117      118.50   -161.92                                   
REMARK 500    MET N 160      169.00    100.63                                   
REMARK 500    ASP N 206     -125.36     59.87                                   
REMARK 500    ALA O  84     -136.11     55.93                                   
REMARK 500    GLU O 117      118.87   -161.97                                   
REMARK 500    ASP O 206     -125.29     59.72                                   
REMARK 500    ALA P  84     -136.56     55.79                                   
REMARK 500    GLU P 117      118.71   -162.69                                   
REMARK 500    ASP P 206     -125.23     59.74                                   
REMARK 500    ALA Q  84     -136.27     55.79                                   
REMARK 500    GLU Q 117      118.28   -162.94                                   
REMARK 500    ASP Q 206     -125.38     59.59                                   
REMARK 500    ALA R  84     -136.47     55.90                                   
REMARK 500    GLU R 117      118.48   -162.51                                   
REMARK 500    ASP R 206     -125.28     59.67                                   
REMARK 500    THR S  64      -70.89   -108.12                                   
REMARK 500    THR T  64      -70.51   -108.00                                   
REMARK 500    CYS T 146      -85.74    -85.40                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      56 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1HMC   RELATED DB: PDB                                   
REMARK 900 HUMAN MACROPHAGE COLONY STIMULATING FACTOR (ALPHA FORM, SOLUBLE)     
DBREF  4ADF A   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF B   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF C   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF D   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF E   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF F   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF G    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF H    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF I    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF J    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF K    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF L    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF M   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF N   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF O   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF P   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF Q   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF R   21   221  UNP    P0CW72   BARF1_EBVG      21    221             
DBREF  4ADF S    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF T    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF U    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF V    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF W    1   149  UNP    P09603   CSF1_HUMAN      33    181             
DBREF  4ADF X    1   149  UNP    P09603   CSF1_HUMAN      33    181             
SEQADV 4ADF LYS A  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS A  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS A  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS A  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS A  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS A  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS A  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER A  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS B  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS B  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS B  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS B  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS B  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS B  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS B  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER B  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS C  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS C  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS C  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS C  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS C  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS C  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS C  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER C  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS D  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS D  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS D  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS D  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS D  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS D  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS D  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER D  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS E  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS E  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS E  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS E  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS E  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS E  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS E  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER E  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS F  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS F  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS F  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS F  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS F  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS F  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS F  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER F  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF GLY G   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER G   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS G   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET G    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY H   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER H   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS H   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET H    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY I   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER I   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS I   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET I    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY J   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER J   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS J   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET J    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY K   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER K   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS K   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET K    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY L   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER L   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS L   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET L    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF LYS M  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS M  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS M  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS M  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS M  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS M  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS M  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER M  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS N  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS N  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS N  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS N  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS N  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS N  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS N  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER N  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS O  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS O  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS O  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS O  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS O  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS O  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS O  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER O  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS P  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS P  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS P  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS P  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS P  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS P  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS P  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER P  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS Q  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS Q  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS Q  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS Q  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS Q  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS Q  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS Q  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER Q  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF LYS R  222  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS R  223  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS R  224  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS R  225  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS R  226  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS R  227  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF HIS R  228  UNP  P0CW72              EXPRESSION TAG                 
SEQADV 4ADF SER R  169  UNP  P0CW72    THR   169 ENGINEERED MUTATION            
SEQADV 4ADF GLY S   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER S   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS S   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET S    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY T   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER T   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS T   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET T    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY U   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER U   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS U   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET U    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY V   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER V   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS V   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET V    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY W   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER W   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS W   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET W    0  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF GLY X   -3  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF SER X   -2  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF HIS X   -1  UNP  P09603              EXPRESSION TAG                 
SEQADV 4ADF MET X    0  UNP  P09603              EXPRESSION TAG                 
SEQRES   1 A  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 A  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 A  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 A  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 A  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 A  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 A  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 A  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 A  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 A  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 A  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 A  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 A  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 A  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 A  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 A  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 B  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 B  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 B  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 B  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 B  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 B  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 B  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 B  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 B  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 B  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 B  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 B  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 B  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 B  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 B  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 B  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 C  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 C  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 C  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 C  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 C  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 C  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 C  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 C  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 C  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 C  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 C  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 C  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 C  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 C  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 C  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 C  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 D  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 D  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 D  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 D  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 D  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 D  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 D  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 D  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 D  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 D  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 D  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 D  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 D  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 D  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 D  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 D  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 E  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 E  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 E  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 E  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 E  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 E  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 E  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 E  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 E  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 E  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 E  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 E  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 E  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 E  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 E  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 E  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 F  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 F  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 F  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 F  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 F  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 F  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 F  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 F  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 F  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 F  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 F  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 F  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 F  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 F  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 F  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 F  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 G  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 G  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 G  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 G  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 G  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 G  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 G  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 G  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 G  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 G  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 G  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 G  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 H  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 H  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 H  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 H  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 H  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 H  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 H  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 H  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 H  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 H  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 H  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 H  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 I  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 I  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 I  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 I  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 I  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 I  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 I  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 I  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 I  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 I  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 I  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 I  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 J  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 J  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 J  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 J  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 J  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 J  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 J  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 J  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 J  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 J  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 J  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 J  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 K  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 K  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 K  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 K  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 K  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 K  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 K  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 K  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 K  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 K  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 K  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 K  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 L  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 L  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 L  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 L  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 L  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 L  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 L  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 L  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 L  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 L  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 L  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 L  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 M  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 M  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 M  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 M  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 M  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 M  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 M  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 M  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 M  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 M  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 M  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 M  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 M  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 M  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 M  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 M  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 N  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 N  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 N  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 N  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 N  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 N  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 N  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 N  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 N  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 N  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 N  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 N  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 N  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 N  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 N  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 N  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 O  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 O  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 O  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 O  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 O  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 O  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 O  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 O  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 O  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 O  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 O  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 O  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 O  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 O  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 O  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 O  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 P  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 P  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 P  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 P  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 P  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 P  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 P  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 P  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 P  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 P  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 P  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 P  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 P  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 P  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 P  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 P  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 Q  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 Q  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 Q  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 Q  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 Q  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 Q  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 Q  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 Q  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 Q  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 Q  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 Q  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 Q  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 Q  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 Q  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 Q  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 Q  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 R  208  VAL THR ALA PHE LEU GLY GLU ARG VAL THR LEU THR SER          
SEQRES   2 R  208  TYR TRP ARG ARG VAL SER LEU GLY PRO GLU ILE GLU VAL          
SEQRES   3 R  208  SER TRP PHE LYS LEU GLY PRO GLY GLU GLU GLN VAL LEU          
SEQRES   4 R  208  ILE GLY ARG MET HIS HIS ASP VAL ILE PHE ILE GLU TRP          
SEQRES   5 R  208  PRO PHE ARG GLY PHE PHE ASP ILE HIS ARG SER ALA ASN          
SEQRES   6 R  208  THR PHE PHE LEU VAL VAL THR ALA ALA ASN ILE SER HIS          
SEQRES   7 R  208  ASP GLY ASN TYR LEU CYS ARG MET LYS LEU GLY GLU THR          
SEQRES   8 R  208  GLU VAL THR LYS GLN GLU HIS LEU SER VAL VAL LYS PRO          
SEQRES   9 R  208  LEU THR LEU SER VAL HIS SER GLU ARG SER GLN PHE PRO          
SEQRES  10 R  208  ASP PHE SER VAL LEU THR VAL THR CYS THR VAL ASN ALA          
SEQRES  11 R  208  PHE PRO HIS PRO HIS VAL GLN TRP LEU MET PRO GLU GLY          
SEQRES  12 R  208  VAL GLU PRO ALA PRO SER ALA ALA ASN GLY GLY VAL MET          
SEQRES  13 R  208  LYS GLU LYS ASP GLY SER LEU SER VAL ALA VAL ASP LEU          
SEQRES  14 R  208  SER LEU PRO LYS PRO TRP HIS LEU PRO VAL THR CYS VAL          
SEQRES  15 R  208  GLY LYS ASN ASP LYS GLU GLU ALA HIS GLY VAL TYR VAL          
SEQRES  16 R  208  SER GLY TYR LEU SER GLN LYS HIS HIS HIS HIS HIS HIS          
SEQRES   1 S  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 S  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 S  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 S  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 S  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 S  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 S  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 S  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 S  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 S  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 S  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 S  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 T  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 T  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 T  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 T  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 T  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 T  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 T  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 T  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 T  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 T  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 T  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 T  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 U  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 U  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 U  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 U  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 U  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 U  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 U  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 U  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 U  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 U  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 U  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 U  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 V  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 V  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 V  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 V  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 V  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 V  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 V  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 V  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 V  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 V  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 V  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 V  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 W  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 W  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 W  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 W  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 W  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 W  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 W  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 W  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 W  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 W  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 W  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 W  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
SEQRES   1 X  153  GLY SER HIS MET GLU GLU VAL SER GLU TYR CYS SER HIS          
SEQRES   2 X  153  MET ILE GLY SER GLY HIS LEU GLN SER LEU GLN ARG LEU          
SEQRES   3 X  153  ILE ASP SER GLN MET GLU THR SER CYS GLN ILE THR PHE          
SEQRES   4 X  153  GLU PHE VAL ASP GLN GLU GLN LEU LYS ASP PRO VAL CYS          
SEQRES   5 X  153  TYR LEU LYS LYS ALA PHE LEU LEU VAL GLN ASP ILE MET          
SEQRES   6 X  153  GLU ASP THR MET ARG PHE ARG ASP ASN THR PRO ASN ALA          
SEQRES   7 X  153  ILE ALA ILE VAL GLN LEU GLN GLU LEU SER LEU ARG LEU          
SEQRES   8 X  153  LYS SER CYS PHE THR LYS ASP TYR GLU GLU HIS ASP LYS          
SEQRES   9 X  153  ALA CYS VAL ARG THR PHE TYR GLU THR PRO LEU GLN LEU          
SEQRES  10 X  153  LEU GLU LYS VAL LYS ASN VAL PHE ASN GLU THR LYS ASN          
SEQRES  11 X  153  LEU LEU ASP LYS ASP TRP ASN ILE PHE SER LYS ASN CYS          
SEQRES  12 X  153  ASN ASN SER PHE ALA GLU CYS SER SER GLN                      
MODRES 4ADF ASN A   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN B   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN C   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN D   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN E   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN F   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN M   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN N   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN O   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN P   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN Q   95  ASN  GLYCOSYLATION SITE                                 
MODRES 4ADF ASN R   95  ASN  GLYCOSYLATION SITE                                 
HET    NAG  Y   1      14                                                       
HET    NAG  Y   2      14                                                       
HET    BMA  Y   3      11                                                       
HET    MAN  Y   4      11                                                       
HET    MAN  Y   5      11                                                       
HET    MAN  Y   6      11                                                       
HET    NAG  Z   1      14                                                       
HET    NAG  Z   2      14                                                       
HET    BMA  Z   3      11                                                       
HET    MAN  Z   4      11                                                       
HET    MAN  Z   5      11                                                       
HET    MAN  Z   6      11                                                       
HET    MAN  Z   7      11                                                       
HET    NAG  a   1      14                                                       
HET    NAG  a   2      14                                                       
HET    BMA  a   3      11                                                       
HET    MAN  a   4      11                                                       
HET    MAN  a   5      11                                                       
HET    MAN  a   6      11                                                       
HET    MAN  a   7      11                                                       
HET    NAG  b   1      14                                                       
HET    NAG  b   2      14                                                       
HET    BMA  b   3      11                                                       
HET    MAN  b   4      11                                                       
HET    MAN  b   5      11                                                       
HET    NAG  c   1      14                                                       
HET    NAG  c   2      14                                                       
HET    BMA  c   3      11                                                       
HET    MAN  c   4      11                                                       
HET    MAN  c   5      11                                                       
HET    NAG  d   1      14                                                       
HET    NAG  d   2      14                                                       
HET    BMA  d   3      11                                                       
HET    MAN  d   4      11                                                       
HET    MAN  d   5      11                                                       
HET    NAG  e   1      14                                                       
HET    NAG  e   2      14                                                       
HET    BMA  e   3      11                                                       
HET    MAN  e   4      11                                                       
HET    MAN  e   5      11                                                       
HET    MAN  e   6      11                                                       
HET    NAG  f   1      14                                                       
HET    NAG  f   2      14                                                       
HET    BMA  f   3      11                                                       
HET    MAN  f   4      11                                                       
HET    MAN  f   5      11                                                       
HET    MAN  f   6      11                                                       
HET    NAG  g   1      14                                                       
HET    NAG  g   2      14                                                       
HET    BMA  g   3      11                                                       
HET    MAN  g   4      11                                                       
HET    MAN  g   5      11                                                       
HET    NAG  h   1      14                                                       
HET    NAG  h   2      14                                                       
HET    BMA  h   3      11                                                       
HET    MAN  h   4      11                                                       
HET    MAN  h   5      11                                                       
HET    MAN  h   6      11                                                       
HET    NAG  i   1      14                                                       
HET    NAG  i   2      14                                                       
HET    BMA  i   3      11                                                       
HET    MAN  i   4      11                                                       
HET    MAN  i   5      11                                                       
HET    MAN  i   6      11                                                       
HET    MAN  i   7      11                                                       
HET    NAG  j   1      14                                                       
HET    NAG  j   2      14                                                       
HET    BMA  j   3      11                                                       
HET    MAN  j   4      11                                                       
HET    MAN  j   5      11                                                       
HET    MAN  j   6      11                                                       
HET    MAN  j   7      11                                                       
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE                         
HETNAM     BMA BETA-D-MANNOPYRANOSE                                             
HETNAM     MAN ALPHA-D-MANNOPYRANOSE                                            
HETSYN     NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA-           
HETSYN   2 NAG  D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO-          
HETSYN   3 NAG  2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE                         
HETSYN     BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE                               
HETSYN     MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE                              
FORMUL  25  NAG    24(C8 H15 N O6)                                              
FORMUL  25  BMA    12(C6 H12 O6)                                                
FORMUL  25  MAN    36(C6 H12 O6)                                                
HELIX    1   1 ASN A   95  ASP A   99  5                                   5    
HELIX    2   2 ASN B   95  ASP B   99  5                                   5    
HELIX    3   3 ASN C   95  ASP C   99  5                                   5    
HELIX    4   4 ASN D   95  ASP D   99  5                                   5    
HELIX    5   5 ASN E   95  ASP E   99  5                                   5    
HELIX    6   6 ASN F   95  ASP F   99  5                                   5    
HELIX    7   7 TYR G    6  MET G   10  5                                   5    
HELIX    8   8 GLY G   12  GLN G   26  1                                  15    
HELIX    9   9 ASP G   45  THR G   64  1                                  20    
HELIX   10  10 THR G   71  LYS G   88  1                                  18    
HELIX   11  11 SER G   89  PHE G   91  5                                   3    
HELIX   12  12 TYR G   95  ASP G   99  5                                   5    
HELIX   13  13 THR G  109  ASP G  131  1                                  23    
HELIX   14  14 TRP G  132  LYS G  137  5                                   6    
HELIX   15  15 CYS G  139  GLU G  145  1                                   7    
HELIX   16  16 TYR H    6  MET H   10  5                                   5    
HELIX   17  17 GLY H   12  GLN H   26  1                                  15    
HELIX   18  18 ASP H   45  THR H   64  1                                  20    
HELIX   19  19 THR H   71  LYS H   88  1                                  18    
HELIX   20  20 SER H   89  PHE H   91  5                                   3    
HELIX   21  21 TYR H   95  ASP H   99  5                                   5    
HELIX   22  22 THR H  109  ASP H  131  1                                  23    
HELIX   23  23 TRP H  132  LYS H  137  5                                   6    
HELIX   24  24 CYS H  139  GLU H  145  1                                   7    
HELIX   25  25 GLY I   12  GLN I   26  1                                  15    
HELIX   26  26 ASP I   45  THR I   64  1                                  20    
HELIX   27  27 THR I   71  LYS I   88  1                                  18    
HELIX   28  28 SER I   89  PHE I   91  5                                   3    
HELIX   29  29 THR I  109  ASP I  131  1                                  23    
HELIX   30  30 TRP I  132  LYS I  137  5                                   6    
HELIX   31  31 CYS I  139  GLU I  145  1                                   7    
HELIX   32  32 TYR J    6  MET J   10  5                                   5    
HELIX   33  33 GLY J   12  GLN J   26  1                                  15    
HELIX   34  34 ASP J   45  THR J   64  1                                  20    
HELIX   35  35 THR J   71  LYS J   88  1                                  18    
HELIX   36  36 SER J   89  PHE J   91  5                                   3    
HELIX   37  37 TYR J   95  ASP J   99  5                                   5    
HELIX   38  38 THR J  109  ASP J  131  1                                  23    
HELIX   39  39 TRP J  132  LYS J  137  5                                   6    
HELIX   40  40 CYS J  139  GLU J  145  1                                   7    
HELIX   41  41 TYR K    6  MET K   10  5                                   5    
HELIX   42  42 GLY K   12  GLN K   26  1                                  15    
HELIX   43  43 ASP K   45  THR K   64  1                                  20    
HELIX   44  44 THR K   71  LYS K   88  1                                  18    
HELIX   45  45 SER K   89  PHE K   91  5                                   3    
HELIX   46  46 TYR K   95  ASP K   99  5                                   5    
HELIX   47  47 THR K  109  ASP K  131  1                                  23    
HELIX   48  48 TRP K  132  LYS K  137  5                                   6    
HELIX   49  49 CYS K  139  GLU K  145  1                                   7    
HELIX   50  50 GLY L   12  GLN L   26  1                                  15    
HELIX   51  51 ASP L   45  THR L   64  1                                  20    
HELIX   52  52 THR L   71  LYS L   88  1                                  18    
HELIX   53  53 SER L   89  PHE L   91  5                                   3    
HELIX   54  54 THR L  109  ASP L  131  1                                  23    
HELIX   55  55 TRP L  132  LYS L  137  5                                   6    
HELIX   56  56 CYS L  139  GLU L  145  1                                   7    
HELIX   57  57 ASN M   95  ASP M   99  5                                   5    
HELIX   58  58 ASN N   95  ASP N   99  5                                   5    
HELIX   59  59 ASN O   95  ASP O   99  5                                   5    
HELIX   60  60 ASN P   95  ASP P   99  5                                   5    
HELIX   61  61 ASN Q   95  ASP Q   99  5                                   5    
HELIX   62  62 ASN R   95  ASP R   99  5                                   5    
HELIX   63  63 TYR S    6  MET S   10  5                                   5    
HELIX   64  64 GLY S   12  GLN S   26  1                                  15    
HELIX   65  65 ASP S   45  THR S   64  1                                  20    
HELIX   66  66 THR S   71  LYS S   88  1                                  18    
HELIX   67  67 SER S   89  PHE S   91  5                                   3    
HELIX   68  68 TYR S   95  ASP S   99  5                                   5    
HELIX   69  69 THR S  109  ASP S  131  1                                  23    
HELIX   70  70 TRP S  132  LYS S  137  5                                   6    
HELIX   71  71 CYS S  139  GLU S  145  1                                   7    
HELIX   72  72 TYR T    6  MET T   10  5                                   5    
HELIX   73  73 GLY T   12  GLN T   26  1                                  15    
HELIX   74  74 ASP T   45  THR T   64  1                                  20    
HELIX   75  75 THR T   71  LYS T   88  1                                  18    
HELIX   76  76 SER T   89  PHE T   91  5                                   3    
HELIX   77  77 TYR T   95  ASP T   99  5                                   5    
HELIX   78  78 THR T  109  ASP T  131  1                                  23    
HELIX   79  79 TRP T  132  LYS T  137  5                                   6    
HELIX   80  80 CYS T  139  GLU T  145  1                                   7    
HELIX   81  81 TYR U    6  MET U   10  5                                   5    
HELIX   82  82 GLY U   12  GLN U   26  1                                  15    
HELIX   83  83 ASP U   45  THR U   64  1                                  20    
HELIX   84  84 THR U   71  LYS U   88  1                                  18    
HELIX   85  85 SER U   89  PHE U   91  5                                   3    
HELIX   86  86 TYR U   95  ASP U   99  5                                   5    
HELIX   87  87 THR U  109  ASP U  131  1                                  23    
HELIX   88  88 TRP U  132  LYS U  137  5                                   6    
HELIX   89  89 CYS U  139  GLU U  145  1                                   7    
HELIX   90  90 TYR V    6  MET V   10  5                                   5    
HELIX   91  91 GLY V   12  GLN V   26  1                                  15    
HELIX   92  92 ASP V   45  THR V   64  1                                  20    
HELIX   93  93 THR V   71  LYS V   88  1                                  18    
HELIX   94  94 SER V   89  PHE V   91  5                                   3    
HELIX   95  95 THR V  109  ASP V  131  1                                  23    
HELIX   96  96 TRP V  132  LYS V  137  5                                   6    
HELIX   97  97 CYS V  139  GLU V  145  1                                   7    
HELIX   98  98 GLY W   12  GLN W   26  1                                  15    
HELIX   99  99 ASP W   45  THR W   64  1                                  20    
HELIX  100 100 THR W   71  LYS W   88  1                                  18    
HELIX  101 101 SER W   89  PHE W   91  5                                   3    
HELIX  102 102 THR W  109  ASP W  131  1                                  23    
HELIX  103 103 TRP W  132  LYS W  137  5                                   6    
HELIX  104 104 CYS W  139  GLU W  145  1                                   7    
HELIX  105 105 TYR X    6  MET X   10  5                                   5    
HELIX  106 106 GLY X   12  GLN X   26  1                                  15    
HELIX  107 107 ASP X   45  THR X   64  1                                  20    
HELIX  108 108 THR X   71  LYS X   88  1                                  18    
HELIX  109 109 SER X   89  PHE X   91  5                                   3    
HELIX  110 110 THR X  109  ASP X  131  1                                  23    
HELIX  111 111 TRP X  132  LYS X  137  5                                   6    
HELIX  112 112 CYS X  139  GLU X  145  1                                   7    
SHEET    1  AA 2 THR A  22  PHE A  24  0                                        
SHEET    2  AA 2 THR A 111  ARG A 133 -1  O  SER A 120   N  ALA A  23           
SHEET    1  AB 8 ILE A  68  ILE A  70  0                                        
SHEET    2  AB 8 VAL A  58  MET A  63  1  O  ARG A  62   N  PHE A  69           
SHEET    3  AB 8 GLU A  45  LYS A  50 -1  O  VAL A  46   N  MET A  63           
SHEET    4  AB 8 GLY A 100  LEU A 108  1  O  LEU A 103   N  PHE A  49           
SHEET    5  AB 8 THR A 111  ARG A 133 -1  O  THR A 111   N  LEU A 108           
SHEET    6  AB 8 LEU A 142  PHE A 151  1  O  THR A 143   N  GLU A 132           
SHEET    7  AB 8 LEU A 183  LEU A 191  1  O  LEU A 183   N  ALA A 150           
SHEET    8  AB 8 GLY A 174  LYS A 177  1  N  GLY A 174   O  ALA A 186           
SHEET    1  AC 9 ILE A  68  ILE A  70  0                                        
SHEET    2  AC 9 VAL A  58  MET A  63  1  O  ARG A  62   N  PHE A  69           
SHEET    3  AC 9 GLU A  45  LYS A  50 -1  O  VAL A  46   N  MET A  63           
SHEET    4  AC 9 GLY A 100  LEU A 108  1  O  LEU A 103   N  PHE A  49           
SHEET    5  AC 9 THR A 111  ARG A 133 -1  O  THR A 111   N  LEU A 108           
SHEET    6  AC 9 THR N 111  ARG N 133 -1  O  GLU N 112   N  GLU A 112           
SHEET    7  AC 9 LEU N 142  PHE N 151 -1  O  THR N 143   N  GLU N 132           
SHEET    8  AC 9 LEU N 183  LEU N 191 -1  O  LEU N 183   N  ALA N 150           
SHEET    9  AC 9 GLY N 173  LYS N 177 -1  N  GLY N 174   O  ALA N 186           
SHEET    1  AD 6 ILE A  68  ILE A  70  0                                        
SHEET    2  AD 6 VAL A  58  MET A  63  1  O  ARG A  62   N  PHE A  69           
SHEET    3  AD 6 GLU A  45  LYS A  50 -1  O  VAL A  46   N  MET A  63           
SHEET    4  AD 6 GLY A 100  LEU A 108  1  O  LEU A 103   N  PHE A  49           
SHEET    5  AD 6 THR A 111  ARG A 133 -1  O  THR A 111   N  LEU A 108           
SHEET    6  AD 6 THR A  22  PHE A  24 -1  O  ALA A  23   N  VAL A 122           
SHEET    1  DA 2 THR D  22  PHE D  24  0                                        
SHEET    2  DA 2 THR D 111  ARG D 133 -1  O  SER D 120   N  ALA D  23           
SHEET    1  AE10 ILE A  68  ILE A  70  0                                        
SHEET    2  AE10 VAL A  58  MET A  63  1  O  ARG A  62   N  PHE A  69           
SHEET    3  AE10 GLU A  45  LYS A  50 -1  O  VAL A  46   N  MET A  63           
SHEET    4  AE10 GLY A 100  LEU A 108  1  O  LEU A 103   N  PHE A  49           
SHEET    5  AE10 THR A 111  ARG A 133 -1  O  THR A 111   N  LEU A 108           
SHEET    6  AE10 THR N 111  ARG N 133 -1  O  GLU N 112   N  GLU A 112           
SHEET    7  AE10 GLY N 100  LEU N 108  1  O  GLY N 100   N  LEU N 119           
SHEET    8  AE10 GLU N  45  LYS N  50  1  O  GLU N  45   N  LYS N 107           
SHEET    9  AE10 VAL N  58  MET N  63  1  O  VAL N  58   N  LYS N  50           
SHEET   10  AE10 ILE N  68  ILE N  70  1  O  PHE N  69   N  ARG N  62           
SHEET    1  AF 7 ILE A  68  ILE A  70  0                                        
SHEET    2  AF 7 VAL A  58  MET A  63  1  O  ARG A  62   N  PHE A  69           
SHEET    3  AF 7 GLU A  45  LYS A  50 -1  O  VAL A  46   N  MET A  63           
SHEET    4  AF 7 GLY A 100  LEU A 108  1  O  LEU A 103   N  PHE A  49           
SHEET    5  AF 7 THR A 111  ARG A 133 -1  O  THR A 111   N  LEU A 108           
SHEET    6  AF 7 THR N 111  ARG N 133 -1  O  GLU N 112   N  GLU A 112           
SHEET    7  AF 7 THR N  22  PHE N  24  1  O  ALA N  23   N  VAL N 122           
SHEET    1  DB 8 ILE D  68  ILE D  70  0                                        
SHEET    2  DB 8 VAL D  58  MET D  63 -1  O  ARG D  62   N  PHE D  69           
SHEET    3  DB 8 GLU D  45  LYS D  50 -1  O  VAL D  46   N  MET D  63           
SHEET    4  DB 8 GLY D 100  LEU D 108 -1  O  LEU D 103   N  PHE D  49           
SHEET    5  DB 8 THR D 111  ARG D 133 -1  O  THR D 111   N  LEU D 108           
SHEET    6  DB 8 LEU D 142  PHE D 151  1  O  THR D 143   N  GLU D 132           
SHEET    7  DB 8 LEU D 183  LEU D 191  1  O  LEU D 183   N  ALA D 150           
SHEET    8  DB 8 VAL D 175  LYS D 177  1  O  MET D 176   N  SER D 184           
SHEET    1  DC 6 ILE D  68  ILE D  70  0                                        
SHEET    2  DC 6 VAL D  58  MET D  63 -1  O  ARG D  62   N  PHE D  69           
SHEET    3  DC 6 GLU D  45  LYS D  50 -1  O  VAL D  46   N  MET D  63           
SHEET    4  DC 6 GLY D 100  LEU D 108 -1  O  LEU D 103   N  PHE D  49           
SHEET    5  DC 6 THR D 111  ARG D 133 -1  O  THR D 111   N  LEU D 108           
SHEET    6  DC 6 THR D  22  PHE D  24 -1  O  ALA D  23   N  VAL D 122           
SHEET    1  RA 2 THR R  22  PHE R  24  0                                        
SHEET    2  RA 2 THR R 111  ARG R 133  1  O  SER R 120   N  ALA R  23           
SHEET    1  DD 9 ILE D  68  ILE D  70  0                                        
SHEET    2  DD 9 VAL D  58  MET D  63 -1  O  ARG D  62   N  PHE D  69           
SHEET    3  DD 9 GLU D  45  LYS D  50 -1  O  VAL D  46   N  MET D  63           
SHEET    4  DD 9 GLY D 100  LEU D 108 -1  O  LEU D 103   N  PHE D  49           
SHEET    5  DD 9 THR D 111  ARG D 133 -1  O  THR D 111   N  LEU D 108           
SHEET    6  DD 9 THR A 111  ARG A 133  1  O  LEU A 127   N  VAL D 129           
SHEET    7  DD 9 LEU A 142  PHE A 151  1  O  THR A 143   N  GLU A 132           
SHEET    8  DD 9 LEU A 183  LEU A 191  1  O  LEU A 183   N  ALA A 150           
SHEET    9  DD 9 GLY A 174  LYS A 177  1  N  GLY A 174   O  ALA A 186           
SHEET    1  DE10 ILE D  68  ILE D  70  0                                        
SHEET    2  DE10 VAL D  58  MET D  63 -1  O  ARG D  62   N  PHE D  69           
SHEET    3  DE10 GLU D  45  LYS D  50 -1  O  VAL D  46   N  MET D  63           
SHEET    4  DE10 GLY D 100  LEU D 108 -1  O  LEU D 103   N  PHE D  49           
SHEET    5  DE10 THR D 111  ARG D 133 -1  O  THR D 111   N  LEU D 108           
SHEET    6  DE10 THR A 111  ARG A 133  1  O  LEU A 127   N  VAL D 129           
SHEET    7  DE10 THR N 111  ARG N 133 -1  O  GLU N 112   N  GLU A 112           
SHEET    8  DE10 LEU N 142  PHE N 151 -1  O  THR N 143   N  GLU N 132           
SHEET    9  DE10 LEU N 183  LEU N 191 -1  O  LEU N 183   N  ALA N 150           
SHEET   10  DE10 GLY N 173  LYS N 177 -1  N  GLY N 174   O  ALA N 186           
SHEET    1  DF10 ILE D  68  ILE D  70  0                                        
SHEET    2  DF10 VAL D  58  MET D  63 -1  O  ARG D  62   N  PHE D  69           
SHEET    3  DF10 GLU D  45  LYS D  50 -1  O  VAL D  46   N  MET D  63           
SHEET    4  DF10 GLY D 100  LEU D 108 -1  O  LEU D 103   N  PHE D  49           
SHEET    5  DF10 THR D 111  ARG D 133 -1  O  THR D 111   N  LEU D 108           
SHEET    6  DF10 THR A 111  ARG A 133  1  O  LEU A 127   N  VAL D 129           
SHEET    7  DF10 GLY A 100  LEU A 108 -1  O  GLY A 100   N  LEU A 119           
SHEET    8  DF10 GLU A  45  LYS A  50 -1  O  GLU A  45   N  LYS A 107           
SHEET    9  DF10 VAL A  58  MET A  63  1  O  VAL A  58   N  LYS A  50           
SHEET   10  DF10 ILE A  68  ILE A  70  1  O  PHE A  69   N  ARG A  62           
SHEET    1  DG11 ILE D  68  ILE D  70  0                                        
SHEET    2  DG11 VAL D  58  MET D  63 -1  O  ARG D  62   N  PHE D  69           
SHEET    3  DG11 GLU D  45  LYS D  50 -1  O  VAL D  46   N  MET D  63           
SHEET    4  DG11 GLY D 100  LEU D 108 -1  O  LEU D 103   N  PHE D  49           
SHEET    5  DG11 THR D 111  ARG D 133 -1  O  THR D 111   N  LEU D 108           
SHEET    6  DG11 THR A 111  ARG A 133  1  O  LEU A 127   N  VAL D 129           
SHEET    7  DG11 THR N 111  ARG N 133 -1  O  GLU N 112   N  GLU A 112           
SHEET    8  DG11 GLY N 100  LEU N 108  1  O  GLY N 100   N  LEU N 119           
SHEET    9  DG11 GLU N  45  LYS N  50  1  O  GLU N  45   N  LYS N 107           
SHEET   10  DG11 VAL N  58  MET N  63  1  O  VAL N  58   N  LYS N  50           
SHEET   11  DG11 ILE N  68  ILE N  70  1  O  PHE N  69   N  ARG N  62           
SHEET    1  DH 8 ILE D  68  ILE D  70  0                                        
SHEET    2  DH 8 VAL D  58  MET D  63 -1  O  ARG D  62   N  PHE D  69           
SHEET    3  DH 8 GLU D  45  LYS D  50 -1  O  VAL D  46   N  MET D  63           
SHEET    4  DH 8 GLY D 100  LEU D 108 -1  O  LEU D 103   N  PHE D  49           
SHEET    5  DH 8 THR D 111  ARG D 133 -1  O  THR D 111   N  LEU D 108           
SHEET    6  DH 8 THR A 111  ARG A 133  1  O  LEU A 127   N  VAL D 129           
SHEET    7  DH 8 THR N 111  ARG N 133 -1  O  GLU N 112   N  GLU A 112           
SHEET    8  DH 8 THR N  22  PHE N  24  1  O  ALA N  23   N  VAL N 122           
SHEET    1  RB 8 ILE R  68  ILE R  70  0                                        
SHEET    2  RB 8 VAL R  58  MET R  63 -1  O  ARG R  62   N  PHE R  69           
SHEET    3  RB 8 GLU R  45  LYS R  50 -1  O  VAL R  46   N  MET R  63           
SHEET    4  RB 8 GLY R 100  LEU R 108 -1  O  LEU R 103   N  PHE R  49           
SHEET    5  RB 8 THR R 111  ARG R 133  1  O  THR R 111   N  LEU R 108           
SHEET    6  RB 8 LEU R 142  PHE R 151  1  O  THR R 143   N  GLU R 132           
SHEET    7  RB 8 LEU R 183  LEU R 191 -1  O  LEU R 183   N  ALA R 150           
SHEET    8  RB 8 MET R 176  LYS R 177 -1  O  MET R 176   N  SER R 184           
SHEET    1  RC 6 ILE R  68  ILE R  70  0                                        
SHEET    2  RC 6 VAL R  58  MET R  63 -1  O  ARG R  62   N  PHE R  69           
SHEET    3  RC 6 GLU R  45  LYS R  50 -1  O  VAL R  46   N  MET R  63           
SHEET    4  RC 6 GLY R 100  LEU R 108 -1  O  LEU R 103   N  PHE R  49           
SHEET    5  RC 6 THR R 111  ARG R 133  1  O  THR R 111   N  LEU R 108           
SHEET    6  RC 6 THR R  22  PHE R  24 -1  O  ALA R  23   N  VAL R 122           
SHEET    1  AG 3 VAL A  29  TYR A  34  0                                        
SHEET    2  AG 3 THR A  86  VAL A  91 -1  O  PHE A  87   N  SER A  33           
SHEET    3  AG 3 PHE A  78  SER A  83 -1  O  ASP A  79   N  VAL A  90           
SHEET    1  AH 6 PRO A 154  TRP A 158  0                                        
SHEET    2  AH 6 VAL A 199  ASN A 205 -1  O  VAL A 202   N  GLN A 157           
SHEET    3  AH 6 GLU A 208  SER A 216 -1  O  GLU A 208   N  ASN A 205           
SHEET    4  AH 6 GLU D 208  SER D 216 -1  O  GLU D 209   N  VAL A 215           
SHEET    5  AH 6 VAL D 199  ASN D 205 -1  O  VAL D 199   N  TYR D 214           
SHEET    6  AH 6 PRO D 154  TRP D 158 -1  O  HIS D 155   N  LYS D 204           
SHEET    1  BA 2 THR B  22  PHE B  24  0                                        
SHEET    2  BA 2 THR B 111  ARG B 133  1  O  SER B 120   N  ALA B  23           
SHEET    1  BB 9 ILE B  68  ILE B  70  0                                        
SHEET    2  BB 9 VAL B  58  MET B  63 -1  O  ARG B  62   N  PHE B  69           
SHEET    3  BB 9 GLU B  45  LYS B  50 -1  O  VAL B  46   N  MET B  63           
SHEET    4  BB 9 GLY B 100  LEU B 108 -1  O  LEU B 103   N  PHE B  49           
SHEET    5  BB 9 THR B 111  ARG B 133 -1  O  THR B 111   N  LEU B 108           
SHEET    6  BB 9 THR F 111  ARG F 133 -1  O  LEU F 125   N  SER B 131           
SHEET    7  BB 9 LEU F 142  PHE F 151 -1  O  THR F 143   N  GLU F 132           
SHEET    8  BB 9 LEU F 183  LEU F 191 -1  O  LEU F 183   N  ALA F 150           
SHEET    9  BB 9 GLY F 173  LYS F 177 -1  N  GLY F 174   O  ALA F 186           
SHEET    1  BC 8 ILE B  68  ILE B  70  0                                        
SHEET    2  BC 8 VAL B  58  MET B  63 -1  O  ARG B  62   N  PHE B  69           
SHEET    3  BC 8 GLU B  45  LYS B  50 -1  O  VAL B  46   N  MET B  63           
SHEET    4  BC 8 GLY B 100  LEU B 108 -1  O  LEU B 103   N  PHE B  49           
SHEET    5  BC 8 THR B 111  ARG B 133 -1  O  THR B 111   N  LEU B 108           
SHEET    6  BC 8 LEU B 142  PHE B 151  1  O  THR B 143   N  GLU B 132           
SHEET    7  BC 8 LEU B 183  LEU B 191 -1  O  LEU B 183   N  ALA B 150           
SHEET    8  BC 8 GLY B 174  LYS B 177 -1  N  GLY B 174   O  ALA B 186           
SHEET    1  BD 6 ILE B  68  ILE B  70  0                                        
SHEET    2  BD 6 VAL B  58  MET B  63 -1  O  ARG B  62   N  PHE B  69           
SHEET    3  BD 6 GLU B  45  LYS B  50 -1  O  VAL B  46   N  MET B  63           
SHEET    4  BD 6 GLY B 100  LEU B 108 -1  O  LEU B 103   N  PHE B  49           
SHEET    5  BD 6 THR B 111  ARG B 133 -1  O  THR B 111   N  LEU B 108           
SHEET    6  BD 6 THR B  22  PHE B  24  1  O  ALA B  23   N  VAL B 122           
SHEET    1  FA 2 THR F  22  PHE F  24  0                                        
SHEET    2  FA 2 THR F 111  ARG F 133 -1  O  SER F 120   N  ALA F  23           
SHEET    1  BE10 ILE B  68  ILE B  70  0                                        
SHEET    2  BE10 VAL B  58  MET B  63 -1  O  ARG B  62   N  PHE B  69           
SHEET    3  BE10 GLU B  45  LYS B  50 -1  O  VAL B  46   N  MET B  63           
SHEET    4  BE10 GLY B 100  LEU B 108 -1  O  LEU B 103   N  PHE B  49           
SHEET    5  BE10 THR B 111  ARG B 133 -1  O  THR B 111   N  LEU B 108           
SHEET    6  BE10 THR F 111  ARG F 133 -1  O  LEU F 125   N  SER B 131           
SHEET    7  BE10 GLY F 100  LEU F 108 -1  O  GLY F 100   N  LEU F 119           
SHEET    8  BE10 GLU F  45  LYS F  50 -1  O  GLU F  45   N  LYS F 107           
SHEET    9  BE10 VAL F  58  MET F  63  1  O  VAL F  58   N  LYS F  50           
SHEET   10  BE10 ILE F  68  ILE F  70  1  O  PHE F  69   N  ARG F  62           
SHEET    1  BF 7 ILE B  68  ILE B  70  0                                        
SHEET    2  BF 7 VAL B  58  MET B  63 -1  O  ARG B  62   N  PHE B  69           
SHEET    3  BF 7 GLU B  45  LYS B  50 -1  O  VAL B  46   N  MET B  63           
SHEET    4  BF 7 GLY B 100  LEU B 108 -1  O  LEU B 103   N  PHE B  49           
SHEET    5  BF 7 THR B 111  ARG B 133 -1  O  THR B 111   N  LEU B 108           
SHEET    6  BF 7 THR F 111  ARG F 133 -1  O  LEU F 125   N  SER B 131           
SHEET    7  BF 7 THR F  22  PHE F  24 -1  O  ALA F  23   N  VAL F 122           
SHEET    1  BG 3 VAL B  29  TYR B  34  0                                        
SHEET    2  BG 3 THR B  86  VAL B  91 -1  O  PHE B  87   N  SER B  33           
SHEET    3  BG 3 PHE B  78  SER B  83 -1  O  ASP B  79   N  VAL B  90           
SHEET    1  BH 6 PRO B 154  TRP B 158  0                                        
SHEET    2  BH 6 VAL B 199  ASN B 205 -1  O  VAL B 202   N  GLN B 157           
SHEET    3  BH 6 GLU B 208  SER B 216 -1  O  GLU B 208   N  ASN B 205           
SHEET    4  BH 6 GLU F 208  SER F 216 -1  O  GLU F 209   N  VAL B 215           
SHEET    5  BH 6 VAL F 199  ASN F 205 -1  O  VAL F 199   N  TYR F 214           
SHEET    6  BH 6 PRO F 154  TRP F 158 -1  O  HIS F 155   N  LYS F 204           
SHEET    1  CA 2 THR C  22  PHE C  24  0                                        
SHEET    2  CA 2 THR C 111  ARG C 133  1  O  SER C 120   N  ALA C  23           
SHEET    1  CB 9 ILE C  68  ILE C  70  0                                        
SHEET    2  CB 9 VAL C  58  MET C  63  1  O  ARG C  62   N  PHE C  69           
SHEET    3  CB 9 GLU C  45  LYS C  50 -1  O  VAL C  46   N  MET C  63           
SHEET    4  CB 9 GLY C 100  LEU C 108 -1  O  LEU C 103   N  PHE C  49           
SHEET    5  CB 9 THR C 111  ARG C 133  1  O  THR C 111   N  LEU C 108           
SHEET    6  CB 9 THR E 111  ARG E 133 -1  O  LEU E 127   N  VAL C 129           
SHEET    7  CB 9 LEU E 142  PHE E 151  1  O  THR E 143   N  GLU E 132           
SHEET    8  CB 9 LEU E 183  LEU E 191  1  O  LEU E 183   N  ALA E 150           
SHEET    9  CB 9 MET E 176  LYS E 177 -1  O  MET E 176   N  SER E 184           
SHEET    1  CC 8 ILE C  68  ILE C  70  0                                        
SHEET    2  CC 8 VAL C  58  MET C  63  1  O  ARG C  62   N  PHE C  69           
SHEET    3  CC 8 GLU C  45  LYS C  50 -1  O  VAL C  46   N  MET C  63           
SHEET    4  CC 8 GLY C 100  LEU C 108 -1  O  LEU C 103   N  PHE C  49           
SHEET    5  CC 8 THR C 111  ARG C 133  1  O  THR C 111   N  LEU C 108           
SHEET    6  CC 8 LEU C 142  PHE C 151 -1  O  THR C 143   N  GLU C 132           
SHEET    7  CC 8 LEU C 183  LEU C 191 -1  O  LEU C 183   N  ALA C 150           
SHEET    8  CC 8 GLY C 174  LYS C 177 -1  N  GLY C 174   O  ALA C 186           
SHEET    1  CD 6 ILE C  68  ILE C  70  0                                        
SHEET    2  CD 6 VAL C  58  MET C  63  1  O  ARG C  62   N  PHE C  69           
SHEET    3  CD 6 GLU C  45  LYS C  50 -1  O  VAL C  46   N  MET C  63           
SHEET    4  CD 6 GLY C 100  LEU C 108 -1  O  LEU C 103   N  PHE C  49           
SHEET    5  CD 6 THR C 111  ARG C 133  1  O  THR C 111   N  LEU C 108           
SHEET    6  CD 6 THR C  22  PHE C  24  1  O  ALA C  23   N  VAL C 122           
SHEET    1  EA 2 THR E  22  PHE E  24  0                                        
SHEET    2  EA 2 THR E 111  ARG E 133 -1  O  SER E 120   N  ALA E  23           
SHEET    1  CE10 ILE C  68  ILE C  70  0                                        
SHEET    2  CE10 VAL C  58  MET C  63  1  O  ARG C  62   N  PHE C  69           
SHEET    3  CE10 GLU C  45  LYS C  50 -1  O  VAL C  46   N  MET C  63           
SHEET    4  CE10 GLY C 100  LEU C 108 -1  O  LEU C 103   N  PHE C  49           
SHEET    5  CE10 THR C 111  ARG C 133  1  O  THR C 111   N  LEU C 108           
SHEET    6  CE10 THR E 111  ARG E 133 -1  O  LEU E 127   N  VAL C 129           
SHEET    7  CE10 GLY E 100  LEU E 108 -1  O  GLY E 100   N  LEU E 119           
SHEET    8  CE10 GLU E  45  LYS E  50 -1  O  GLU E  45   N  LYS E 107           
SHEET    9  CE10 VAL E  58  MET E  63 -1  O  VAL E  58   N  LYS E  50           
SHEET   10  CE10 ILE E  68  ILE E  70 -1  O  PHE E  69   N  ARG E  62           
SHEET    1  CF 7 ILE C  68  ILE C  70  0                                        
SHEET    2  CF 7 VAL C  58  MET C  63  1  O  ARG C  62   N  PHE C  69           
SHEET    3  CF 7 GLU C  45  LYS C  50 -1  O  VAL C  46   N  MET C  63           
SHEET    4  CF 7 GLY C 100  LEU C 108 -1  O  LEU C 103   N  PHE C  49           
SHEET    5  CF 7 THR C 111  ARG C 133  1  O  THR C 111   N  LEU C 108           
SHEET    6  CF 7 THR E 111  ARG E 133 -1  O  LEU E 127   N  VAL C 129           
SHEET    7  CF 7 THR E  22  PHE E  24 -1  O  ALA E  23   N  VAL E 122           
SHEET    1  CG 3 VAL C  29  TYR C  34  0                                        
SHEET    2  CG 3 THR C  86  VAL C  91 -1  O  PHE C  87   N  SER C  33           
SHEET    3  CG 3 PHE C  78  SER C  83 -1  O  ASP C  79   N  VAL C  90           
SHEET    1  CH 6 PRO C 154  TRP C 158  0                                        
SHEET    2  CH 6 VAL C 199  ASN C 205 -1  O  VAL C 202   N  GLN C 157           
SHEET    3  CH 6 GLU C 208  SER C 216 -1  O  GLU C 208   N  ASN C 205           
SHEET    4  CH 6 GLU E 208  SER E 216 -1  O  GLU E 209   N  VAL C 215           
SHEET    5  CH 6 VAL E 199  ASN E 205 -1  O  VAL E 199   N  TYR E 214           
SHEET    6  CH 6 PRO E 154  TRP E 158 -1  O  HIS E 155   N  LYS E 204           
SHEET    1  DI 3 VAL D  29  TYR D  34  0                                        
SHEET    2  DI 3 THR D  86  VAL D  91 -1  O  PHE D  87   N  SER D  33           
SHEET    3  DI 3 PHE D  78  SER D  83 -1  O  ASP D  79   N  VAL D  90           
SHEET    1  EB 3 VAL E  29  TYR E  34  0                                        
SHEET    2  EB 3 THR E  86  VAL E  91 -1  O  PHE E  87   N  SER E  33           
SHEET    3  EB 3 PHE E  78  SER E  83 -1  O  ASP E  79   N  VAL E  90           
SHEET    1  FB 3 VAL F  29  TYR F  34  0                                        
SHEET    2  FB 3 THR F  86  VAL F  91 -1  O  PHE F  87   N  SER F  33           
SHEET    3  FB 3 PHE F  78  SER F  83 -1  O  ASP F  79   N  VAL F  90           
SHEET    1  GA 2 ILE G  33  VAL G  38  0                                        
SHEET    2  GA 2 VAL G 103  GLU G 108 -1  O  ARG G 104   N  PHE G  37           
SHEET    1  HA 2 ILE H  33  VAL H  38  0                                        
SHEET    2  HA 2 VAL H 103  GLU H 108 -1  O  ARG H 104   N  PHE H  37           
SHEET    1  IA 2 ILE I  33  VAL I  38  0                                        
SHEET    2  IA 2 VAL I 103  GLU I 108 -1  O  ARG I 104   N  PHE I  37           
SHEET    1  JA 2 ILE J  33  VAL J  38  0                                        
SHEET    2  JA 2 VAL J 103  GLU J 108 -1  O  ARG J 104   N  PHE J  37           
SHEET    1  KA 2 ILE K  33  VAL K  38  0                                        
SHEET    2  KA 2 VAL K 103  GLU K 108 -1  O  ARG K 104   N  PHE K  37           
SHEET    1  LA 2 ILE L  33  VAL L  38  0                                        
SHEET    2  LA 2 VAL L 103  GLU L 108 -1  O  ARG L 104   N  PHE L  37           
SHEET    1  MA 2 THR M  22  PHE M  24  0                                        
SHEET    2  MA 2 THR M 111  ARG M 133  1  O  SER M 120   N  ALA M  23           
SHEET    1  MB 9 ILE M  68  ILE M  70  0                                        
SHEET    2  MB 9 VAL M  58  MET M  63  1  O  ARG M  62   N  PHE M  69           
SHEET    3  MB 9 GLU M  45  LYS M  50 -1  O  VAL M  46   N  MET M  63           
SHEET    4  MB 9 GLY M 100  LEU M 108 -1  O  LEU M 103   N  PHE M  49           
SHEET    5  MB 9 THR M 111  ARG M 133  1  O  THR M 111   N  LEU M 108           
SHEET    6  MB 9 THR O 111  ARG O 133 -1  O  LEU O 125   N  SER M 131           
SHEET    7  MB 9 LEU O 142  PHE O 151  1  O  THR O 143   N  GLU O 132           
SHEET    8  MB 9 LEU O 183  LEU O 191  1  O  LEU O 183   N  ALA O 150           
SHEET    9  MB 9 MET O 176  LYS O 177  1  O  MET O 176   N  SER O 184           
SHEET    1  MC 8 ILE M  68  ILE M  70  0                                        
SHEET    2  MC 8 VAL M  58  MET M  63  1  O  ARG M  62   N  PHE M  69           
SHEET    3  MC 8 GLU M  45  LYS M  50 -1  O  VAL M  46   N  MET M  63           
SHEET    4  MC 8 GLY M 100  LEU M 108 -1  O  LEU M 103   N  PHE M  49           
SHEET    5  MC 8 THR M 111  ARG M 133  1  O  THR M 111   N  LEU M 108           
SHEET    6  MC 8 LEU M 142  PHE M 151  1  O  THR M 143   N  GLU M 132           
SHEET    7  MC 8 LEU M 183  LEU M 191 -1  O  LEU M 183   N  ALA M 150           
SHEET    8  MC 8 VAL M 175  LYS M 177 -1  O  MET M 176   N  SER M 184           
SHEET    1  MD 6 ILE M  68  ILE M  70  0                                        
SHEET    2  MD 6 VAL M  58  MET M  63  1  O  ARG M  62   N  PHE M  69           
SHEET    3  MD 6 GLU M  45  LYS M  50 -1  O  VAL M  46   N  MET M  63           
SHEET    4  MD 6 GLY M 100  LEU M 108 -1  O  LEU M 103   N  PHE M  49           
SHEET    5  MD 6 THR M 111  ARG M 133  1  O  THR M 111   N  LEU M 108           
SHEET    6  MD 6 THR M  22  PHE M  24  1  O  ALA M  23   N  VAL M 122           
SHEET    1  OA 2 THR O  22  PHE O  24  0                                        
SHEET    2  OA 2 THR O 111  ARG O 133 -1  O  SER O 120   N  ALA O  23           
SHEET    1  ME10 ILE M  68  ILE M  70  0                                        
SHEET    2  ME10 VAL M  58  MET M  63  1  O  ARG M  62   N  PHE M  69           
SHEET    3  ME10 GLU M  45  LYS M  50 -1  O  VAL M  46   N  MET M  63           
SHEET    4  ME10 GLY M 100  LEU M 108 -1  O  LEU M 103   N  PHE M  49           
SHEET    5  ME10 THR M 111  ARG M 133  1  O  THR M 111   N  LEU M 108           
SHEET    6  ME10 THR O 111  ARG O 133 -1  O  LEU O 125   N  SER M 131           
SHEET    7  ME10 GLY O 100  LEU O 108 -1  O  GLY O 100   N  LEU O 119           
SHEET    8  ME10 GLU O  45  LYS O  50 -1  O  GLU O  45   N  LYS O 107           
SHEET    9  ME10 VAL O  58  MET O  63 -1  O  VAL O  58   N  LYS O  50           
SHEET   10  ME10 ILE O  68  ILE O  70 -1  O  PHE O  69   N  ARG O  62           
SHEET    1  MF 7 ILE M  68  ILE M  70  0                                        
SHEET    2  MF 7 VAL M  58  MET M  63  1  O  ARG M  62   N  PHE M  69           
SHEET    3  MF 7 GLU M  45  LYS M  50 -1  O  VAL M  46   N  MET M  63           
SHEET    4  MF 7 GLY M 100  LEU M 108 -1  O  LEU M 103   N  PHE M  49           
SHEET    5  MF 7 THR M 111  ARG M 133  1  O  THR M 111   N  LEU M 108           
SHEET    6  MF 7 THR O 111  ARG O 133 -1  O  LEU O 125   N  SER M 131           
SHEET    7  MF 7 THR O  22  PHE O  24  1  O  ALA O  23   N  VAL O 122           
SHEET    1  MG 3 VAL M  29  TYR M  34  0                                        
SHEET    2  MG 3 THR M  86  VAL M  91 -1  O  PHE M  87   N  SER M  33           
SHEET    3  MG 3 PHE M  78  SER M  83 -1  O  ASP M  79   N  VAL M  90           
SHEET    1  MH 6 PRO M 154  TRP M 158  0                                        
SHEET    2  MH 6 VAL M 199  ASN M 205 -1  O  VAL M 202   N  GLN M 157           
SHEET    3  MH 6 GLU M 208  SER M 216 -1  O  GLU M 208   N  ASN M 205           
SHEET    4  MH 6 GLU O 208  SER O 216 -1  O  GLU O 209   N  VAL M 215           
SHEET    5  MH 6 VAL O 199  ASN O 205 -1  O  VAL O 199   N  TYR O 214           
SHEET    6  MH 6 PRO O 154  LEU O 159 -1  O  HIS O 155   N  LYS O 204           
SHEET    1  NA 3 VAL N  29  TYR N  34  0                                        
SHEET    2  NA 3 THR N  86  VAL N  91 -1  O  PHE N  87   N  SER N  33           
SHEET    3  NA 3 PHE N  78  SER N  83 -1  O  ASP N  79   N  VAL N  90           
SHEET    1  NB 6 PRO N 154  TRP N 158  0                                        
SHEET    2  NB 6 VAL N 199  ASN N 205 -1  O  VAL N 202   N  GLN N 157           
SHEET    3  NB 6 GLU N 208  SER N 216 -1  O  GLU N 208   N  ASN N 205           
SHEET    4  NB 6 GLU R 208  SER R 216 -1  O  GLU R 209   N  VAL N 215           
SHEET    5  NB 6 VAL R 199  ASN R 205 -1  O  VAL R 199   N  TYR R 214           
SHEET    6  NB 6 PRO R 154  TRP R 158 -1  O  HIS R 155   N  LYS R 204           
SHEET    1  OB 3 VAL O  29  TYR O  34  0                                        
SHEET    2  OB 3 THR O  86  VAL O  91 -1  O  PHE O  87   N  SER O  33           
SHEET    3  OB 3 PHE O  78  SER O  83 -1  O  ASP O  79   N  VAL O  90           
SHEET    1  PA 2 THR P  22  PHE P  24  0                                        
SHEET    2  PA 2 THR P 111  ARG P 133  1  O  SER P 120   N  ALA P  23           
SHEET    1  PB 9 ILE P  68  ILE P  70  0                                        
SHEET    2  PB 9 VAL P  58  MET P  63  1  O  ARG P  62   N  PHE P  69           
SHEET    3  PB 9 GLU P  45  LYS P  50 -1  O  VAL P  46   N  MET P  63           
SHEET    4  PB 9 GLY P 100  LEU P 108 -1  O  LEU P 103   N  PHE P  49           
SHEET    5  PB 9 THR P 111  ARG P 133  1  O  THR P 111   N  LEU P 108           
SHEET    6  PB 9 THR Q 111  ARG Q 133 -1  O  LEU Q 127   N  VAL P 129           
SHEET    7  PB 9 LEU Q 142  PHE Q 151  1  O  THR Q 143   N  GLU Q 132           
SHEET    8  PB 9 LEU Q 183  LEU Q 191  1  O  LEU Q 183   N  ALA Q 150           
SHEET    9  PB 9 MET Q 176  LYS Q 177 -1  O  MET Q 176   N  SER Q 184           
SHEET    1  PC 8 ILE P  68  ILE P  70  0                                        
SHEET    2  PC 8 VAL P  58  MET P  63  1  O  ARG P  62   N  PHE P  69           
SHEET    3  PC 8 GLU P  45  LYS P  50 -1  O  VAL P  46   N  MET P  63           
SHEET    4  PC 8 GLY P 100  LEU P 108 -1  O  LEU P 103   N  PHE P  49           
SHEET    5  PC 8 THR P 111  ARG P 133  1  O  THR P 111   N  LEU P 108           
SHEET    6  PC 8 LEU P 142  PHE P 151 -1  O  THR P 143   N  GLU P 132           
SHEET    7  PC 8 LEU P 183  LEU P 191 -1  O  LEU P 183   N  ALA P 150           
SHEET    8  PC 8 GLY P 174  LYS P 177 -1  O  GLY P 174   N  ALA P 186           
SHEET    1  PD 6 ILE P  68  ILE P  70  0                                        
SHEET    2  PD 6 VAL P  58  MET P  63  1  O  ARG P  62   N  PHE P  69           
SHEET    3  PD 6 GLU P  45  LYS P  50 -1  O  VAL P  46   N  MET P  63           
SHEET    4  PD 6 GLY P 100  LEU P 108 -1  O  LEU P 103   N  PHE P  49           
SHEET    5  PD 6 THR P 111  ARG P 133  1  O  THR P 111   N  LEU P 108           
SHEET    6  PD 6 THR P  22  PHE P  24  1  O  ALA P  23   N  VAL P 122           
SHEET    1  QA 2 THR Q  22  PHE Q  24  0                                        
SHEET    2  QA 2 THR Q 111  ARG Q 133 -1  O  SER Q 120   N  ALA Q  23           
SHEET    1  PE10 ILE P  68  ILE P  70  0                                        
SHEET    2  PE10 VAL P  58  MET P  63  1  O  ARG P  62   N  PHE P  69           
SHEET    3  PE10 GLU P  45  LYS P  50 -1  O  VAL P  46   N  MET P  63           
SHEET    4  PE10 GLY P 100  LEU P 108 -1  O  LEU P 103   N  PHE P  49           
SHEET    5  PE10 THR P 111  ARG P 133  1  O  THR P 111   N  LEU P 108           
SHEET    6  PE10 THR Q 111  ARG Q 133 -1  O  LEU Q 127   N  VAL P 129           
SHEET    7  PE10 GLY Q 100  LEU Q 108 -1  O  GLY Q 100   N  LEU Q 119           
SHEET    8  PE10 GLU Q  45  LYS Q  50 -1  O  GLU Q  45   N  LYS Q 107           
SHEET    9  PE10 VAL Q  58  MET Q  63 -1  O  VAL Q  58   N  LYS Q  50           
SHEET   10  PE10 ILE Q  68  ILE Q  70 -1  O  PHE Q  69   N  ARG Q  62           
SHEET    1  PF 7 ILE P  68  ILE P  70  0                                        
SHEET    2  PF 7 VAL P  58  MET P  63  1  O  ARG P  62   N  PHE P  69           
SHEET    3  PF 7 GLU P  45  LYS P  50 -1  O  VAL P  46   N  MET P  63           
SHEET    4  PF 7 GLY P 100  LEU P 108 -1  O  LEU P 103   N  PHE P  49           
SHEET    5  PF 7 THR P 111  ARG P 133  1  O  THR P 111   N  LEU P 108           
SHEET    6  PF 7 THR Q 111  ARG Q 133 -1  O  LEU Q 127   N  VAL P 129           
SHEET    7  PF 7 THR Q  22  PHE Q  24 -1  O  ALA Q  23   N  VAL Q 122           
SHEET    1  PG 3 VAL P  29  TYR P  34  0                                        
SHEET    2  PG 3 THR P  86  VAL P  91 -1  O  PHE P  87   N  SER P  33           
SHEET    3  PG 3 PHE P  78  SER P  83 -1  O  ASP P  79   N  VAL P  90           
SHEET    1  PH 6 PRO P 154  TRP P 158  0                                        
SHEET    2  PH 6 VAL P 199  ASN P 205 -1  O  VAL P 202   N  GLN P 157           
SHEET    3  PH 6 GLU P 208  SER P 216 -1  O  GLU P 208   N  ASN P 205           
SHEET    4  PH 6 GLU Q 208  SER Q 216 -1  O  GLU Q 209   N  VAL P 215           
SHEET    5  PH 6 VAL Q 199  ASN Q 205 -1  O  VAL Q 199   N  TYR Q 214           
SHEET    6  PH 6 PRO Q 154  TRP Q 158 -1  O  HIS Q 155   N  LYS Q 204           
SHEET    1  QB 3 VAL Q  29  TYR Q  34  0                                        
SHEET    2  QB 3 THR Q  86  VAL Q  91 -1  O  PHE Q  87   N  SER Q  33           
SHEET    3  QB 3 PHE Q  78  SER Q  83 -1  O  ASP Q  79   N  VAL Q  90           
SHEET    1  RD 3 VAL R  29  TYR R  34  0                                        
SHEET    2  RD 3 THR R  86  VAL R  91 -1  O  PHE R  87   N  SER R  33           
SHEET    3  RD 3 PHE R  78  SER R  83 -1  O  ASP R  79   N  VAL R  90           
SHEET    1  SA 2 ILE S  33  VAL S  38  0                                        
SHEET    2  SA 2 VAL S 103  GLU S 108 -1  O  ARG S 104   N  PHE S  37           
SHEET    1  TA 2 ILE T  33  VAL T  38  0                                        
SHEET    2  TA 2 VAL T 103  GLU T 108 -1  O  ARG T 104   N  PHE T  37           
SHEET    1  UA 2 ILE U  33  VAL U  38  0                                        
SHEET    2  UA 2 VAL U 103  GLU U 108 -1  O  ARG U 104   N  PHE U  37           
SHEET    1  VA 2 ILE V  33  VAL V  38  0                                        
SHEET    2  VA 2 VAL V 103  GLU V 108 -1  O  ARG V 104   N  PHE V  37           
SHEET    1  WA 2 ILE W  33  VAL W  38  0                                        
SHEET    2  WA 2 VAL W 103  GLU W 108 -1  O  ARG W 104   N  PHE W  37           
SHEET    1  XA 2 ILE X  33  VAL X  38  0                                        
SHEET    2  XA 2 VAL X 103  GLU X 108 -1  O  ARG X 104   N  PHE X  37           
SSBOND   1 CYS A  146    CYS A  201                          1555   1555  2.03  
SSBOND   2 CYS B  146    CYS B  201                          1555   1555  2.04  
SSBOND   3 CYS C  146    CYS C  201                          1555   1555  2.03  
SSBOND   4 CYS D  146    CYS D  201                          1555   1555  2.03  
SSBOND   5 CYS E  146    CYS E  201                          1555   1555  2.03  
SSBOND   6 CYS F  146    CYS F  201                          1555   1555  2.03  
SSBOND   7 CYS G    7    CYS G   90                          1555   1555  2.03  
SSBOND   8 CYS G   31    CYS H   31                          1555   1555  2.03  
SSBOND   9 CYS G   48    CYS G  139                          1555   1555  2.03  
SSBOND  10 CYS G  102    CYS G  146                          1555   1555  2.04  
SSBOND  11 CYS H    7    CYS H   90                          1555   1555  2.04  
SSBOND  12 CYS H   48    CYS H  139                          1555   1555  2.03  
SSBOND  13 CYS H  102    CYS H  146                          1555   1555  2.03  
SSBOND  14 CYS I    7    CYS I   90                          1555   1555  2.03  
SSBOND  15 CYS I   31    CYS J   31                          1555   1555  2.03  
SSBOND  16 CYS I   48    CYS I  139                          1555   1555  2.03  
SSBOND  17 CYS I  102    CYS I  146                          1555   1555  2.04  
SSBOND  18 CYS J    7    CYS J   90                          1555   1555  2.02  
SSBOND  19 CYS J   48    CYS J  139                          1555   1555  2.04  
SSBOND  20 CYS J  102    CYS J  146                          1555   1555  2.03  
SSBOND  21 CYS K    7    CYS K   90                          1555   1555  2.04  
SSBOND  22 CYS K   31    CYS L   31                          1555   1555  2.02  
SSBOND  23 CYS K   48    CYS K  139                          1555   1555  2.03  
SSBOND  24 CYS K  102    CYS K  146                          1555   1555  2.04  
SSBOND  25 CYS L    7    CYS L   90                          1555   1555  2.04  
SSBOND  26 CYS L   48    CYS L  139                          1555   1555  2.03  
SSBOND  27 CYS L  102    CYS L  146                          1555   1555  2.03  
SSBOND  28 CYS M  146    CYS M  201                          1555   1555  2.03  
SSBOND  29 CYS N  146    CYS N  201                          1555   1555  2.04  
SSBOND  30 CYS O  146    CYS O  201                          1555   1555  2.03  
SSBOND  31 CYS P  146    CYS P  201                          1555   1555  2.03  
SSBOND  32 CYS Q  146    CYS Q  201                          1555   1555  2.03  
SSBOND  33 CYS R  146    CYS R  201                          1555   1555  2.04  
SSBOND  34 CYS S    7    CYS S   90                          1555   1555  2.04  
SSBOND  35 CYS S   31    CYS T   31                          1555   1555  2.02  
SSBOND  36 CYS S   48    CYS S  139                          1555   1555  2.03  
SSBOND  37 CYS S  102    CYS S  146                          1555   1555  2.04  
SSBOND  38 CYS T    7    CYS T   90                          1555   1555  2.04  
SSBOND  39 CYS T   48    CYS T  139                          1555   1555  2.03  
SSBOND  40 CYS T  102    CYS T  146                          1555   1555  2.03  
SSBOND  41 CYS U    7    CYS U   90                          1555   1555  2.03  
SSBOND  42 CYS U   31    CYS V   31                          1555   1555  2.02  
SSBOND  43 CYS U   48    CYS U  139                          1555   1555  2.03  
SSBOND  44 CYS U  102    CYS U  146                          1555   1555  2.03  
SSBOND  45 CYS V    7    CYS V   90                          1555   1555  2.04  
SSBOND  46 CYS V   48    CYS V  139                          1555   1555  2.03  
SSBOND  47 CYS V  102    CYS V  146                          1555   1555  2.03  
SSBOND  48 CYS W    7    CYS W   90                          1555   1555  2.03  
SSBOND  49 CYS W   31    CYS X   31                          1555   1555  2.03  
SSBOND  50 CYS W   48    CYS W  139                          1555   1555  2.03  
SSBOND  51 CYS W  102    CYS W  146                          1555   1555  2.04  
SSBOND  52 CYS X    7    CYS X   90                          1555   1555  2.04  
SSBOND  53 CYS X   48    CYS X  139                          1555   1555  2.03  
SSBOND  54 CYS X  102    CYS X  146                          1555   1555  2.03  
LINK         ND2 ASN A  95                 C1  NAG Y   1     1555   1555  1.45  
LINK         ND2 ASN B  95                 C1  NAG Z   1     1555   1555  1.46  
LINK         ND2 ASN C  95                 C1  NAG a   1     1555   1555  1.46  
LINK         ND2 ASN D  95                 C1  NAG b   1     1555   1555  1.47  
LINK         ND2 ASN E  95                 C1  NAG c   1     1555   1555  1.46  
LINK         ND2 ASN F  95                 C1  NAG d   1     1555   1555  1.46  
LINK         ND2 ASN M  95                 C1  NAG e   1     1555   1555  1.45  
LINK         ND2 ASN N  95                 C1  NAG f   1     1555   1555  1.45  
LINK         ND2 ASN O  95                 C1  NAG g   1     1555   1555  1.44  
LINK         ND2 ASN P  95                 C1  NAG h   1     1555   1555  1.45  
LINK         ND2 ASN Q  95                 C1  NAG i   1     1555   1555  1.45  
LINK         ND2 ASN R  95                 C1  NAG j   1     1555   1555  1.46  
LINK         O4  NAG Y   1                 C1  NAG Y   2     1555   1555  1.45  
LINK         O4  NAG Y   2                 C1  BMA Y   3     1555   1555  1.45  
LINK         O6  BMA Y   3                 C1  MAN Y   4     1555   1555  1.45  
LINK         O3  BMA Y   3                 C1  MAN Y   6     1555   1555  1.44  
LINK         O6  MAN Y   4                 C1  MAN Y   5     1555   1555  1.44  
LINK         O4  NAG Z   1                 C1  NAG Z   2     1555   1555  1.46  
LINK         O4  NAG Z   2                 C1  BMA Z   3     1555   1555  1.46  
LINK         O6  BMA Z   3                 C1  MAN Z   4     1555   1555  1.45  
LINK         O3  BMA Z   3                 C1  MAN Z   7     1555   1555  1.46  
LINK         O3  MAN Z   4                 C1  MAN Z   5     1555   1555  1.44  
LINK         O6  MAN Z   4                 C1  MAN Z   6     1555   1555  1.44  
LINK         O4  NAG a   1                 C1  NAG a   2     1555   1555  1.45  
LINK         O4  NAG a   2                 C1  BMA a   3     1555   1555  1.45  
LINK         O6  BMA a   3                 C1  MAN a   4     1555   1555  1.45  
LINK         O3  BMA a   3                 C1  MAN a   7     1555   1555  1.45  
LINK         O3  MAN a   4                 C1  MAN a   5     1555   1555  1.44  
LINK         O6  MAN a   4                 C1  MAN a   6     1555   1555  1.44  
LINK         O4  NAG b   1                 C1  NAG b   2     1555   1555  1.46  
LINK         O4  NAG b   2                 C1  BMA b   3     1555   1555  1.46  
LINK         O3  BMA b   3                 C1  MAN b   4     1555   1555  1.44  
LINK         O6  BMA b   3                 C1  MAN b   5     1555   1555  1.44  
LINK         O4  NAG c   1                 C1  NAG c   2     1555   1555  1.46  
LINK         O4  NAG c   2                 C1  BMA c   3     1555   1555  1.45  
LINK         O3  BMA c   3                 C1  MAN c   4     1555   1555  1.45  
LINK         O6  BMA c   3                 C1  MAN c   5     1555   1555  1.45  
LINK         O4  NAG d   1                 C1  NAG d   2     1555   1555  1.45  
LINK         O4  NAG d   2                 C1  BMA d   3     1555   1555  1.47  
LINK         O3  BMA d   3                 C1  MAN d   4     1555   1555  1.45  
LINK         O6  BMA d   3                 C1  MAN d   5     1555   1555  1.45  
LINK         O4  NAG e   1                 C1  NAG e   2     1555   1555  1.44  
LINK         O4  NAG e   2                 C1  BMA e   3     1555   1555  1.44  
LINK         O6  BMA e   3                 C1  MAN e   4     1555   1555  1.46  
LINK         O3  BMA e   3                 C1  MAN e   6     1555   1555  1.45  
LINK         O6  MAN e   4                 C1  MAN e   5     1555   1555  1.43  
LINK         O4  NAG f   1                 C1  NAG f   2     1555   1555  1.45  
LINK         O4  NAG f   2                 C1  BMA f   3     1555   1555  1.45  
LINK         O6  BMA f   3                 C1  MAN f   4     1555   1555  1.45  
LINK         O3  BMA f   3                 C1  MAN f   6     1555   1555  1.45  
LINK         O6  MAN f   4                 C1  MAN f   5     1555   1555  1.45  
LINK         O4  NAG g   1                 C1  NAG g   2     1555   1555  1.44  
LINK         O4  NAG g   2                 C1  BMA g   3     1555   1555  1.44  
LINK         O3  BMA g   3                 C1  MAN g   4     1555   1555  1.44  
LINK         O6  BMA g   3                 C1  MAN g   5     1555   1555  1.44  
LINK         O4  NAG h   1                 C1  NAG h   2     1555   1555  1.45  
LINK         O4  NAG h   2                 C1  BMA h   3     1555   1555  1.46  
LINK         O6  BMA h   3                 C1  MAN h   4     1555   1555  1.44  
LINK         O3  BMA h   3                 C1  MAN h   6     1555   1555  1.45  
LINK         O6  MAN h   4                 C1  MAN h   5     1555   1555  1.44  
LINK         O4  NAG i   1                 C1  NAG i   2     1555   1555  1.44  
LINK         O4  NAG i   2                 C1  BMA i   3     1555   1555  1.45  
LINK         O6  BMA i   3                 C1  MAN i   4     1555   1555  1.45  
LINK         O3  BMA i   3                 C1  MAN i   7     1555   1555  1.45  
LINK         O3  MAN i   4                 C1  MAN i   5     1555   1555  1.45  
LINK         O6  MAN i   4                 C1  MAN i   6     1555   1555  1.45  
LINK         O4  NAG j   1                 C1  NAG j   2     1555   1555  1.45  
LINK         O4  NAG j   2                 C1  BMA j   3     1555   1555  1.45  
LINK         O6  BMA j   3                 C1  MAN j   4     1555   1555  1.44  
LINK         O3  BMA j   3                 C1  MAN j   7     1555   1555  1.46  
LINK         O3  MAN j   4                 C1  MAN j   5     1555   1555  1.44  
LINK         O6  MAN j   4                 C1  MAN j   6     1555   1555  1.44  
CISPEP   1 PHE A  136    PRO A  137          0        -5.55                     
CISPEP   2 PHE A  151    PRO A  152          0         8.26                     
CISPEP   3 LYS A  193    PRO A  194          0        -2.10                     
CISPEP   4 LEU A  197    PRO A  198          0        -7.91                     
CISPEP   5 PHE B  136    PRO B  137          0        -5.37                     
CISPEP   6 PHE B  151    PRO B  152          0         8.36                     
CISPEP   7 LYS B  193    PRO B  194          0        -1.83                     
CISPEP   8 LEU B  197    PRO B  198          0        -7.35                     
CISPEP   9 PHE C  136    PRO C  137          0        -5.47                     
CISPEP  10 PHE C  151    PRO C  152          0         8.57                     
CISPEP  11 LYS C  193    PRO C  194          0        -2.12                     
CISPEP  12 LEU C  197    PRO C  198          0        -7.97                     
CISPEP  13 PHE D  136    PRO D  137          0        -5.45                     
CISPEP  14 PHE D  151    PRO D  152          0         8.34                     
CISPEP  15 LYS D  193    PRO D  194          0        -0.41                     
CISPEP  16 LEU D  197    PRO D  198          0        -7.39                     
CISPEP  17 PHE E  136    PRO E  137          0        -5.57                     
CISPEP  18 PHE E  151    PRO E  152          0         8.57                     
CISPEP  19 LYS E  193    PRO E  194          0        -1.68                     
CISPEP  20 LEU E  197    PRO E  198          0        -7.89                     
CISPEP  21 PHE F  136    PRO F  137          0        -5.68                     
CISPEP  22 PHE F  151    PRO F  152          0         8.39                     
CISPEP  23 LYS F  193    PRO F  194          0        -1.75                     
CISPEP  24 LEU F  197    PRO F  198          0        -8.17                     
CISPEP  25 PHE M  136    PRO M  137          0        -5.60                     
CISPEP  26 PHE M  151    PRO M  152          0         8.32                     
CISPEP  27 LYS M  193    PRO M  194          0        -2.01                     
CISPEP  28 LEU M  197    PRO M  198          0        -7.59                     
CISPEP  29 PHE N  136    PRO N  137          0        -5.45                     
CISPEP  30 PHE N  151    PRO N  152          0         8.54                     
CISPEP  31 MET N  160    PRO N  161          0        -2.05                     
CISPEP  32 LYS N  193    PRO N  194          0        -1.78                     
CISPEP  33 LEU N  197    PRO N  198          0        -7.97                     
CISPEP  34 PHE O  136    PRO O  137          0        -5.54                     
CISPEP  35 PHE O  151    PRO O  152          0         8.31                     
CISPEP  36 MET O  160    PRO O  161          0        -0.81                     
CISPEP  37 LYS O  193    PRO O  194          0        -1.78                     
CISPEP  38 LEU O  197    PRO O  198          0        -8.65                     
CISPEP  39 PHE P  136    PRO P  137          0        -5.52                     
CISPEP  40 PHE P  151    PRO P  152          0         8.50                     
CISPEP  41 LYS P  193    PRO P  194          0        -1.76                     
CISPEP  42 LEU P  197    PRO P  198          0        -7.68                     
CISPEP  43 PHE Q  136    PRO Q  137          0        -5.59                     
CISPEP  44 PHE Q  151    PRO Q  152          0         8.40                     
CISPEP  45 LYS Q  193    PRO Q  194          0        -2.13                     
CISPEP  46 LEU Q  197    PRO Q  198          0        -7.98                     
CISPEP  47 PHE R  136    PRO R  137          0        -5.47                     
CISPEP  48 PHE R  151    PRO R  152          0         8.31                     
CISPEP  49 LYS R  193    PRO R  194          0        -1.87                     
CISPEP  50 LEU R  197    PRO R  198          0        -7.39                     
CRYST1  218.440  218.440  331.170  90.00  90.00 120.00 P 31 2 1     72          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.004578  0.002643  0.000000        0.00000                         
SCALE2      0.000000  0.005286  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.003020        0.00000                         
MTRIX1   1  0.380200  0.878900  0.288200      -11.97540    1                    
MTRIX2   1  0.887600 -0.434200  0.153400      -26.44570    1                    
MTRIX3   1  0.260000  0.197500 -0.945200      146.57280    1                    
MTRIX1   2 -0.060000 -0.668200 -0.741600      -57.06790    1                    
MTRIX2   2 -0.711300  0.549800 -0.437900      -43.44340    1                    
MTRIX3   2  0.700300  0.501300 -0.508200      164.32330    1                    
MTRIX1   3 -0.428500  0.365200 -0.826500      -22.87230    1                    
MTRIX2   3  0.378700 -0.757900 -0.531200      -34.00660    1                    
MTRIX3   3 -0.820300 -0.540600  0.186500      -31.14340    1                    
MTRIX1   4 -0.815800  0.058300  0.575300     -150.46410    1                    
MTRIX2   4  0.162900 -0.931400  0.325400     -109.77840    1                    
MTRIX3   4  0.554900  0.359200  0.750400       69.77630    1                    
MTRIX1   5 -0.027300 -0.696400  0.717100     -146.31620    1                    
MTRIX2   5 -0.705200  0.521900  0.480000     -101.04060    1                    
MTRIX3   5 -0.708500 -0.492600 -0.505400       20.34150    1                    
MTRIX1   6  0.875200  0.015300 -0.483500       35.76670    1                    
MTRIX2   6 -0.200100  0.921400 -0.333000      -52.79920    1                    
MTRIX3   6  0.440400  0.388200  0.809500       90.50620    1                    
MTRIX1   7  0.279100  0.926200 -0.253500      -19.15160    1                    
MTRIX2   7  0.938500 -0.319000 -0.132100       41.89330    1                    
MTRIX3   7 -0.203200 -0.201000 -0.958300       62.37860    1                    
MTRIX1   8 -0.806600  0.023900 -0.590600     -131.09810    1                    
MTRIX2   8  0.228000 -0.909300 -0.348200      -31.61640    1                    
MTRIX3   8 -0.545300 -0.415500  0.728000      -16.84110    1                    
MTRIX1   9 -0.257400 -0.904600 -0.339700      -93.26440    1                    
MTRIX2   9 -0.902500  0.350700 -0.250200     -132.61270    1                    
MTRIX3   9  0.345400  0.242200 -0.906600      121.19700    1                    
MTRIX1  10 -0.498900  0.293800  0.815300     -131.15210    1                    
MTRIX2  10  0.436700 -0.727400  0.529300      -30.70660    1                    
MTRIX3  10  0.748600  0.620100  0.234600      138.31570    1                    
MTRIX1  11  0.396700 -0.356900  0.845700      -50.51250    1                    
MTRIX2  11 -0.496500  0.691500  0.524700     -106.28290    1                    
MTRIX3  11 -0.772100 -0.628000  0.097100      -26.33590    1                    
MTRIX1  12 -0.086200  0.775500 -0.625400      -86.66940    1                    
MTRIX2  12  0.776600 -0.340900 -0.529700       75.97970    1                    
MTRIX3  12 -0.624000 -0.531400 -0.572900      -32.30200    1                    
MTRIX1  13  0.169900 -0.719600 -0.673300      -78.35330    1                    
MTRIX2  13 -0.658800  0.425200 -0.620700      -59.01740    1                    
MTRIX3  13  0.732900  0.549000 -0.401800      110.78040    1                    
MTRIX1  14 -0.984500  0.051300 -0.167700     -195.24620    1                    
MTRIX2  14 -0.038200 -0.996000 -0.080200      -24.90150    1                    
MTRIX3  14 -0.171100 -0.072600  0.982600      -15.70650    1                    
MTRIX1  15  0.158200 -0.743400  0.649800     -112.17270    1                    
MTRIX2  15 -0.746100  0.341100  0.571800      -95.04280    1                    
MTRIX3  15 -0.646800 -0.575300 -0.500700      -34.90370    1                    
MTRIX1  16 -0.180500  0.720100  0.669900     -129.08690    1                    
MTRIX2  16  0.719500 -0.367700  0.589200       40.49840    1                    
MTRIX3  16  0.670600  0.588400 -0.451800      106.94870    1                    
MTRIX1  17  0.452000  0.875900  0.168900        1.50560    1                    
MTRIX2  17  0.877900 -0.470300  0.089600      -27.09730    1                    
MTRIX3  17  0.157900  0.107800 -0.981600      130.53470    1                    
MTRIX1  18 -0.086500 -0.630300 -0.771500      -53.43910    1                    
MTRIX2  18 -0.638900  0.629300 -0.442500      -36.68860    1                    
MTRIX3  18  0.764400  0.454600 -0.457100      160.49760    1                    
MTRIX1  19 -0.462100  0.314700 -0.829100      -26.22740    1                    
MTRIX2  19  0.330800 -0.806200 -0.490500      -43.22300    1                    
MTRIX3  19 -0.822800 -0.500900  0.268500      -38.24390    1                    
MTRIX1  20 -0.104200 -0.696300  0.710200     -149.26500    1                    
MTRIX2  20 -0.745600  0.527200  0.407500     -101.60870    1                    
MTRIX3  20 -0.658200 -0.487100 -0.574100       24.22020    1                    
MTRIX1  21 -0.812600  0.029500  0.582100     -151.41880    1                    
MTRIX2  21  0.210800 -0.916300  0.340500     -107.71350    1                    
MTRIX3  21  0.543500  0.399400  0.738300       71.38440    1                    
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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