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Database: PDB
Entry: 4KZX
LinkDB: 4KZX
Original site: 4KZX 
HEADER    RIBOSOME                                30-MAY-13   4KZX              
TITLE     RABBIT 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH EIF1.                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 40S RIBOSOMAL PROTEIN SA;                                  
COMPND   3 CHAIN: A;                                                            
COMPND   4 MOL_ID: 2;                                                           
COMPND   5 MOLECULE: 40S RIBOSOMAL PROTEIN S3A;                                 
COMPND   6 CHAIN: B;                                                            
COMPND   7 MOL_ID: 3;                                                           
COMPND   8 MOLECULE: 40S RIBOSOMAL PROTEIN S2;                                  
COMPND   9 CHAIN: C;                                                            
COMPND  10 MOL_ID: 4;                                                           
COMPND  11 MOLECULE: 40S RIBOSOMAL PROTEIN S3;                                  
COMPND  12 CHAIN: D;                                                            
COMPND  13 MOL_ID: 5;                                                           
COMPND  14 MOLECULE: 40S RIBOSOMAL PROTEIN S4X;                                 
COMPND  15 CHAIN: E;                                                            
COMPND  16 MOL_ID: 6;                                                           
COMPND  17 MOLECULE: 40S RIBOSOMAL PROTEIN S5;                                  
COMPND  18 CHAIN: F;                                                            
COMPND  19 MOL_ID: 7;                                                           
COMPND  20 MOLECULE: 40S RIBOSOMAL PROTEIN S6;                                  
COMPND  21 CHAIN: G;                                                            
COMPND  22 MOL_ID: 8;                                                           
COMPND  23 MOLECULE: 40S RIBOSOMAL PROTEIN S7;                                  
COMPND  24 CHAIN: H;                                                            
COMPND  25 MOL_ID: 9;                                                           
COMPND  26 MOLECULE: 40S RIBOSOMAL PROTEIN S8;                                  
COMPND  27 CHAIN: I;                                                            
COMPND  28 MOL_ID: 10;                                                          
COMPND  29 MOLECULE: 40S RIBOSOMAL PROTEIN S9;                                  
COMPND  30 CHAIN: J;                                                            
COMPND  31 MOL_ID: 11;                                                          
COMPND  32 MOLECULE: 40S RIBOSOMAL PROTEIN S10;                                 
COMPND  33 CHAIN: K;                                                            
COMPND  34 MOL_ID: 12;                                                          
COMPND  35 MOLECULE: 40S RIBOSOMAL PROTEIN S11;                                 
COMPND  36 CHAIN: L;                                                            
COMPND  37 MOL_ID: 13;                                                          
COMPND  38 MOLECULE: 40S RIBOSOMAL PROTEIN S12;                                 
COMPND  39 CHAIN: M;                                                            
COMPND  40 MOL_ID: 14;                                                          
COMPND  41 MOLECULE: 40S RIBOSOMAL PROTEIN S13;                                 
COMPND  42 CHAIN: N;                                                            
COMPND  43 MOL_ID: 15;                                                          
COMPND  44 MOLECULE: 40S RIBOSOMAL PROTEIN S14;                                 
COMPND  45 CHAIN: O;                                                            
COMPND  46 MOL_ID: 16;                                                          
COMPND  47 MOLECULE: 40S RIBOSOMAL PROTEIN S15;                                 
COMPND  48 CHAIN: P;                                                            
COMPND  49 MOL_ID: 17;                                                          
COMPND  50 MOLECULE: 40S RIBOSOMAL PROTEIN S16;                                 
COMPND  51 CHAIN: Q;                                                            
COMPND  52 MOL_ID: 18;                                                          
COMPND  53 MOLECULE: 40S RIBOSOMAL PROTEIN S17;                                 
COMPND  54 CHAIN: R;                                                            
COMPND  55 MOL_ID: 19;                                                          
COMPND  56 MOLECULE: 40S RIBOSOMAL PROTEIN S18;                                 
COMPND  57 CHAIN: S;                                                            
COMPND  58 MOL_ID: 20;                                                          
COMPND  59 MOLECULE: 40S RIBOSOMAL PROTEIN S19;                                 
COMPND  60 CHAIN: T;                                                            
COMPND  61 MOL_ID: 21;                                                          
COMPND  62 MOLECULE: 40S RIBOSOMAL PROTEIN S20;                                 
COMPND  63 CHAIN: U;                                                            
COMPND  64 MOL_ID: 22;                                                          
COMPND  65 MOLECULE: 40S RIBOSOMAL PROTEIN S21;                                 
COMPND  66 CHAIN: V;                                                            
COMPND  67 MOL_ID: 23;                                                          
COMPND  68 MOLECULE: 40S RIBOSOMAL PROTEIN S15A;                                
COMPND  69 CHAIN: W;                                                            
COMPND  70 MOL_ID: 24;                                                          
COMPND  71 MOLECULE: 40S RIBOSOMAL PROTEIN S23;                                 
COMPND  72 CHAIN: X;                                                            
COMPND  73 MOL_ID: 25;                                                          
COMPND  74 MOLECULE: 40S RIBOSOMAL PROTEIN S24;                                 
COMPND  75 CHAIN: Y;                                                            
COMPND  76 MOL_ID: 26;                                                          
COMPND  77 MOLECULE: 40S RIBOSOMAL PROTEIN S25;                                 
COMPND  78 CHAIN: Z;                                                            
COMPND  79 MOL_ID: 27;                                                          
COMPND  80 MOLECULE: 40S RIBOSOMAL PROTEIN S26;                                 
COMPND  81 CHAIN: a;                                                            
COMPND  82 MOL_ID: 28;                                                          
COMPND  83 MOLECULE: 40S RIBOSOMAL PROTEIN S27;                                 
COMPND  84 CHAIN: b;                                                            
COMPND  85 MOL_ID: 29;                                                          
COMPND  86 MOLECULE: 40S RIBOSOMAL PROTEIN S28;                                 
COMPND  87 CHAIN: c;                                                            
COMPND  88 MOL_ID: 30;                                                          
COMPND  89 MOLECULE: 40S RIBOSOMAL PROTEIN S29;                                 
COMPND  90 CHAIN: d;                                                            
COMPND  91 MOL_ID: 31;                                                          
COMPND  92 MOLECULE: 40S RIBOSOMAL PROTEIN S30;                                 
COMPND  93 CHAIN: e;                                                            
COMPND  94 MOL_ID: 32;                                                          
COMPND  95 MOLECULE: 40S RIBOSOMAL PROTEIN S27A;                                
COMPND  96 CHAIN: f;                                                            
COMPND  97 MOL_ID: 33;                                                          
COMPND  98 MOLECULE: 40S RIBOSOMAL PROTEIN RACK1;                               
COMPND  99 CHAIN: g;                                                            
COMPND 100 MOL_ID: 34;                                                          
COMPND 101 MOLECULE: 18S RIBOSOMAL RNA;                                         
COMPND 102 CHAIN: i;                                                            
COMPND 103 MOL_ID: 35;                                                          
COMPND 104 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 1;                
COMPND 105 CHAIN: l;                                                            
COMPND 106 SYNONYM: EIF1, A121, PROTEIN TRANSLATION FACTOR SUI1 HOMOLOG,        
COMPND 107 SUI1ISO1;                                                            
COMPND 108 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE   3 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE   4 RABBIT,RABBITS;                                                      
SOURCE   5 ORGANISM_TAXID: 9986;                                                
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE   8 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE   9 RABBIT,RABBITS;                                                      
SOURCE  10 ORGANISM_TAXID: 9986;                                                
SOURCE  11 MOL_ID: 3;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  13 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  14 RABBIT,RABBITS;                                                      
SOURCE  15 ORGANISM_TAXID: 9986;                                                
SOURCE  16 MOL_ID: 4;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  18 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  19 RABBIT,RABBITS;                                                      
SOURCE  20 ORGANISM_TAXID: 9986;                                                
SOURCE  21 MOL_ID: 5;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  23 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  24 RABBIT,RABBITS;                                                      
SOURCE  25 ORGANISM_TAXID: 9986;                                                
SOURCE  26 MOL_ID: 6;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  28 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  29 RABBIT,RABBITS;                                                      
SOURCE  30 ORGANISM_TAXID: 9986;                                                
SOURCE  31 MOL_ID: 7;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  33 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  34 RABBIT,RABBITS;                                                      
SOURCE  35 ORGANISM_TAXID: 9986;                                                
SOURCE  36 MOL_ID: 8;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  38 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  39 RABBIT,RABBITS;                                                      
SOURCE  40 ORGANISM_TAXID: 9986;                                                
SOURCE  41 MOL_ID: 9;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  43 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  44 RABBIT,RABBITS;                                                      
SOURCE  45 ORGANISM_TAXID: 9986;                                                
SOURCE  46 MOL_ID: 10;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  48 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  49 RABBIT,RABBITS;                                                      
SOURCE  50 ORGANISM_TAXID: 9986;                                                
SOURCE  51 MOL_ID: 11;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  53 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  54 RABBIT,RABBITS;                                                      
SOURCE  55 ORGANISM_TAXID: 9986;                                                
SOURCE  56 MOL_ID: 12;                                                          
SOURCE  57 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  58 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  59 RABBIT,RABBITS;                                                      
SOURCE  60 ORGANISM_TAXID: 9986;                                                
SOURCE  61 MOL_ID: 13;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  63 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  64 RABBIT,RABBITS;                                                      
SOURCE  65 ORGANISM_TAXID: 9986;                                                
SOURCE  66 MOL_ID: 14;                                                          
SOURCE  67 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  68 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  69 RABBIT,RABBITS;                                                      
SOURCE  70 ORGANISM_TAXID: 9986;                                                
SOURCE  71 MOL_ID: 15;                                                          
SOURCE  72 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  73 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  74 RABBIT,RABBITS;                                                      
SOURCE  75 ORGANISM_TAXID: 9986;                                                
SOURCE  76 MOL_ID: 16;                                                          
SOURCE  77 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  78 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  79 RABBIT,RABBITS;                                                      
SOURCE  80 ORGANISM_TAXID: 9986;                                                
SOURCE  81 MOL_ID: 17;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  83 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  84 RABBIT,RABBITS;                                                      
SOURCE  85 ORGANISM_TAXID: 9986;                                                
SOURCE  86 MOL_ID: 18;                                                          
SOURCE  87 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  88 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  89 RABBIT,RABBITS;                                                      
SOURCE  90 ORGANISM_TAXID: 9986;                                                
SOURCE  91 MOL_ID: 19;                                                          
SOURCE  92 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  93 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  94 RABBIT,RABBITS;                                                      
SOURCE  95 ORGANISM_TAXID: 9986;                                                
SOURCE  96 MOL_ID: 20;                                                          
SOURCE  97 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  98 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE  99 RABBIT,RABBITS;                                                      
SOURCE 100 ORGANISM_TAXID: 9986;                                                
SOURCE 101 MOL_ID: 21;                                                          
SOURCE 102 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 103 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 104 RABBIT,RABBITS;                                                      
SOURCE 105 ORGANISM_TAXID: 9986;                                                
SOURCE 106 MOL_ID: 22;                                                          
SOURCE 107 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 108 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 109 RABBIT,RABBITS;                                                      
SOURCE 110 ORGANISM_TAXID: 9986;                                                
SOURCE 111 MOL_ID: 23;                                                          
SOURCE 112 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 113 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 114 RABBIT,RABBITS;                                                      
SOURCE 115 ORGANISM_TAXID: 9986;                                                
SOURCE 116 MOL_ID: 24;                                                          
SOURCE 117 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 118 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 119 RABBIT,RABBITS;                                                      
SOURCE 120 ORGANISM_TAXID: 9986;                                                
SOURCE 121 MOL_ID: 25;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 123 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 124 RABBIT,RABBITS;                                                      
SOURCE 125 ORGANISM_TAXID: 9986;                                                
SOURCE 126 MOL_ID: 26;                                                          
SOURCE 127 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 128 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 129 RABBIT,RABBITS;                                                      
SOURCE 130 ORGANISM_TAXID: 9986;                                                
SOURCE 131 MOL_ID: 27;                                                          
SOURCE 132 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 133 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 134 RABBIT,RABBITS;                                                      
SOURCE 135 ORGANISM_TAXID: 9986;                                                
SOURCE 136 MOL_ID: 28;                                                          
SOURCE 137 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 138 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 139 RABBIT,RABBITS;                                                      
SOURCE 140 ORGANISM_TAXID: 9986;                                                
SOURCE 141 MOL_ID: 29;                                                          
SOURCE 142 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 143 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 144 RABBIT,RABBITS;                                                      
SOURCE 145 ORGANISM_TAXID: 9986;                                                
SOURCE 146 MOL_ID: 30;                                                          
SOURCE 147 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 148 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 149 RABBIT,RABBITS;                                                      
SOURCE 150 ORGANISM_TAXID: 9986;                                                
SOURCE 151 MOL_ID: 31;                                                          
SOURCE 152 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 153 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 154 RABBIT,RABBITS;                                                      
SOURCE 155 ORGANISM_TAXID: 9986;                                                
SOURCE 156 MOL_ID: 32;                                                          
SOURCE 157 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 158 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 159 RABBIT,RABBITS;                                                      
SOURCE 160 ORGANISM_TAXID: 9986;                                                
SOURCE 161 MOL_ID: 33;                                                          
SOURCE 162 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 163 ORGANISM_COMMON: EUROPEAN RABBIT,JAPANESE WHITE RABBIT,DOMESTIC      
SOURCE 164 RABBIT,RABBITS;                                                      
SOURCE 165 ORGANISM_TAXID: 9986;                                                
SOURCE 166 MOL_ID: 34;                                                          
SOURCE 167 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 168 ORGANISM_COMMON: RABBIT;                                             
SOURCE 169 ORGANISM_TAXID: 9986;                                                
SOURCE 170 MOL_ID: 35;                                                          
SOURCE 171 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 172 ORGANISM_COMMON: HUMAN;                                              
SOURCE 173 ORGANISM_TAXID: 9606;                                                
SOURCE 174 STRAIN: K12;                                                         
SOURCE 175 GENE: EIF1, SUI1;                                                    
SOURCE 176 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 177 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE 178 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE 179 EXPRESSION_SYSTEM_VECTOR_TYPE: PET28A;                               
SOURCE 180 EXPRESSION_SYSTEM_PLASMID: PET28A-HEIF1TEV                           
KEYWDS    RIBOSOME, TRANSLATION INITIATION, PREINITIATION COMPLEX               
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    I.B.LOMAKIN,T.A.STEITZ                                                
REVDAT   3   04-SEP-13 4KZX    1       JRNL                                     
REVDAT   2   07-AUG-13 4KZX    1       JRNL                                     
REVDAT   1   24-JUL-13 4KZX    0                                                
JRNL        AUTH   I.B.LOMAKIN,T.A.STEITZ                                       
JRNL        TITL   THE INITIATION OF MAMMALIAN PROTEIN SYNTHESIS AND MRNA       
JRNL        TITL 2 SCANNING MECHANISM.                                          
JRNL        REF    NATURE                        V. 500   307 2013              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   23873042                                                     
JRNL        DOI    10.1038/NATURE12355                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    7.81 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.7.3_928)                    
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 7.81                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 58.11                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.330                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 94.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 25914                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.347                           
REMARK   3   R VALUE            (WORKING SET) : 0.347                           
REMARK   3   FREE R VALUE                     : 0.347                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.030                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1304                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 58.1134 - 16.1397    0.98     2985   148  0.3096 0.2971        
REMARK   3     2 16.1397 - 12.8562    1.00     2926   148  0.3608 0.3838        
REMARK   3     3 12.8562 - 11.2444    1.00     2862   165  0.3582 0.3308        
REMARK   3     4 11.2444 - 10.2224    1.00     2857   179  0.3512 0.3509        
REMARK   3     5 10.2224 -  9.4931    1.00     2851   156  0.3863 0.4208        
REMARK   3     6  9.4931 -  8.9355    1.00     2867   141  0.3912 0.4186        
REMARK   3     7  8.9355 -  8.4894    1.00     2822   146  0.4027 0.4322        
REMARK   3     8  8.4894 -  8.1209    0.98     2764   134  0.4199 0.4597        
REMARK   3     9  8.1209 -  7.8090    0.58     1676    87  0.4443 0.4356        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.00                                          
REMARK   3   SHRINKAGE RADIUS   : 1.20                                          
REMARK   3   K_SOL              : 0.33                                          
REMARK   3   B_SOL              : 100.00                                        
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 1.460            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 42.900           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 667.15                         
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 217.00                         
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 669.98320                                            
REMARK   3    B22 (A**2) : 669.98320                                            
REMARK   3    B33 (A**2) : 411.79780                                            
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.026          82358                                  
REMARK   3   ANGLE     :  2.813         119496                                  
REMARK   3   CHIRALITY :  0.240          14752                                  
REMARK   3   PLANARITY :  0.022           8633                                  
REMARK   3   DIHEDRAL  : 20.690          36996                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 7                                          
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: segid S03A or segid S05A or segid S10A or segid S12A   
REMARK   3               or segid S15A or segid S16A or segid S17A or segid     
REMARK   3               S18A or segid S19A or segid S20A or segid S25A or      
REMARK   3               segid S28A or segid S29A or segid 27aA or segid RACA   
REMARK   3               or (segid 18SA and resid 1207:1683)                    
REMARK   3    ORIGIN FOR THE GROUP (A):  62.3202 106.4116-127.3955              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3118 T22:   4.9696                                     
REMARK   3      T33:   1.7906 T12:  -0.6536                                     
REMARK   3      T13:  -0.4995 T23:  -0.4839                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7926 L22:   2.6555                                     
REMARK   3      L33:   2.3150 L12:   0.6813                                     
REMARK   3      L13:   0.5619 L23:  -0.0043                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4233 S12:   2.1075 S13:   0.4872                       
REMARK   3      S21:  -0.8649 S22:   0.5159 S23:  -0.0268                       
REMARK   3      S31:   0.4227 S32:   1.0452 S33:   0.2027                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: segid 18SA and resid 184:209                           
REMARK   3    ORIGIN FOR THE GROUP (A):   2.0692 146.0292  53.4198              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   5.0265 T22:   4.3357                                     
REMARK   3      T33:   2.5711 T12:   2.0329                                     
REMARK   3      T13:  -0.6894 T23:  -1.0204                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0025 L22:   0.0074                                     
REMARK   3      L33:   0.0408 L12:   0.0134                                     
REMARK   3      L13:   0.0251 L23:   0.0168                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2427 S12:   0.3065 S13:  -0.4522                       
REMARK   3      S21:   0.6632 S22:  -0.3154 S23:   0.2492                       
REMARK   3      S31:  -0.0519 S32:   0.1525 S33:   0.0113                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: segid 18SA and resid 305:326                           
REMARK   3    ORIGIN FOR THE GROUP (A):  -3.1208 187.4242  17.2085              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   6.6439 T22:   5.2810                                     
REMARK   3      T33:   3.7684 T12:  -0.2890                                     
REMARK   3      T13:  -0.6716 T23:   0.0041                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3555 L22:   0.2295                                     
REMARK   3      L33:   0.3324 L12:   0.1004                                     
REMARK   3      L13:  -0.1483 L23:  -0.2285                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3007 S12:   0.3588 S13:  -0.1738                       
REMARK   3      S21:   0.1006 S22:   0.1739 S23:   0.5492                       
REMARK   3      S31:  -0.1082 S32:   0.5105 S33:   0.0544                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: segid 18SA and resid 681:737                           
REMARK   3    ORIGIN FOR THE GROUP (A): -19.5575 122.6743 -38.0131              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   3.6660 T22:   6.4594                                     
REMARK   3      T33:   6.3133 T12:  -0.9402                                     
REMARK   3      T13:   0.6960 T23:  -0.3542                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0230 L22:  -0.0102                                     
REMARK   3      L33:   0.0169 L12:  -0.0126                                     
REMARK   3      L13:  -0.0018 L23:   0.0048                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2375 S12:   0.1112 S13:  -0.3176                       
REMARK   3      S21:   0.0375 S22:  -0.1351 S23:  -0.1064                       
REMARK   3      S31:   0.1457 S32:  -0.0762 S33:  -0.0996                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: segid 18SA and resid 1699:1826                         
REMARK   3    ORIGIN FOR THE GROUP (A):  56.7550 154.2341  -6.3013              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8419 T22:   2.4271                                     
REMARK   3      T33:   2.1032 T12:  -0.1671                                     
REMARK   3      T13:  -0.8559 T23:   0.9789                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3733 L22:   0.7460                                     
REMARK   3      L33:   1.7398 L12:   0.3935                                     
REMARK   3      L13:   0.3865 L23:  -0.6007                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1037 S12:   0.3861 S13:   0.5532                       
REMARK   3      S21:  -0.3689 S22:   0.5007 S23:   0.9459                       
REMARK   3      S31:  -1.0436 S32:  -0.7608 S33:   0.2316                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: segid S0aA or segid S3aA or segid S02A or segid S4xA   
REMARK   3               or segid S06A or segid S07A or segid S08A or segid     
REMARK   3               S09A or segid S11A or segid S13A or segid S14A or      
REMARK   3               segid S21A or segid 15aA or segid S23A or segid S24A   
REMARK   3               or segid S26A or segid S27A or segid S30A or (segid    
REMARK   3               18SA and not resid 184:209 and not resid 305:326 and   
REMARK   3               not resid 681:737 and not resid 1207:1683 and not      
REMARK   3               resid 1699:1826)                                       
REMARK   3    ORIGIN FOR THE GROUP (A):  28.9121 121.2674 -32.1810              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4024 T22:   1.2014                                     
REMARK   3      T33:   0.8705 T12:   0.0338                                     
REMARK   3      T13:   0.4643 T23:  -0.4771                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3716 L22:   3.1314                                     
REMARK   3      L33:   1.6545 L12:  -1.3500                                     
REMARK   3      L13:   0.6987 L23:   0.0549                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5243 S12:   0.1175 S13:  -0.2075                       
REMARK   3      S21:   0.9268 S22:   0.4937 S23:   1.1748                       
REMARK   3      S31:   0.1012 S32:  -1.0024 S33:   0.5669                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: segid eF1A                                             
REMARK   3    ORIGIN FOR THE GROUP (A):  95.1674 114.4632 -66.9617              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.0673 T22:   3.3589                                     
REMARK   3      T33:   3.1378 T12:  -1.0351                                     
REMARK   3      T13:   0.7957 T23:  -1.5800                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4192 L22:   0.5641                                     
REMARK   3      L33:   0.9366 L12:  -0.1263                                     
REMARK   3      L13:  -0.1005 L23:  -0.6619                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3723 S12:  -0.1155 S13:   0.1445                       
REMARK   3      S21:   0.1729 S22:   0.5416 S23:   0.4428                       
REMARK   3      S31:   0.1697 S32:   0.4706 S33:  -0.5861                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: AUTHORS PERFORMED RIGID BODY REFINEMENT   
REMARK   3  USING THE HUMAN PROTEINS WITH SIDECHAINS FROM PDB ENTRIES 3J3A      
REMARK   3  AND 3J3D. THIS RESULTS IN CLOSE CONTACTS BETWEEN SIDECHAINS         
REMARK   4                                                                      
REMARK   4 4KZX COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-JUN-13.                  
REMARK 100 THE RCSB ID CODE IS RCSB080005.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 24-JUL-11                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 8.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : NSLS                               
REMARK 200  BEAMLINE                       : X25                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.1                                
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XDS                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 17938                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 9.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 80.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.3                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB ENTRY 3J3A AND 3J3D                              
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 74.10                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.75                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M AMMONIUM ACETATE, 0.05M TRIS-HCL    
REMARK 280  PH 8.5, 2.5% PEG-20K, 4-6% MPD, 5.0MM MG ACETATE, 2.0MM TCEP,       
REMARK 280  VAPOR DIFFUSION, TEMPERATURE 292K                                   
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 31 2 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+1/3                                            
REMARK 290       3555   -X+Y,-X,Z+2/3                                           
REMARK 290       4555   Y,X,-Z                                                  
REMARK 290       5555   X-Y,-Y,-Z+2/3                                           
REMARK 290       6555   -X,-X+Y,-Z+1/3                                          
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      159.22233            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      318.44467            
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000      318.44467            
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000      159.22233            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 REMARK: MONOMER                                                      
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 35-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I,            
REMARK 350                    AND CHAINS: J, K, L, M, N, O, P, Q, R,            
REMARK 350                    AND CHAINS: S, T, U, V, W, X, Y, Z, a,            
REMARK 350                    AND CHAINS: b, c, d, e, f, g, i, l                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ILE A   210                                                      
REMARK 465     GLU A   211                                                      
REMARK 465     LYS A   212                                                      
REMARK 465     GLU A   213                                                      
REMARK 465     GLU A   214                                                      
REMARK 465     GLN A   215                                                      
REMARK 465     ALA A   216                                                      
REMARK 465     ALA A   217                                                      
REMARK 465     ALA A   218                                                      
REMARK 465     GLU A   219                                                      
REMARK 465     LYS A   220                                                      
REMARK 465     ALA A   221                                                      
REMARK 465     VAL A   222                                                      
REMARK 465     THR A   223                                                      
REMARK 465     LYS A   224                                                      
REMARK 465     GLU A   225                                                      
REMARK 465     GLU A   226                                                      
REMARK 465     PHE A   227                                                      
REMARK 465     GLN A   228                                                      
REMARK 465     GLY A   229                                                      
REMARK 465     GLU A   230                                                      
REMARK 465     TRP A   231                                                      
REMARK 465     THR A   232                                                      
REMARK 465     ALA A   233                                                      
REMARK 465     PRO A   234                                                      
REMARK 465     ALA A   235                                                      
REMARK 465     PRO A   236                                                      
REMARK 465     GLU A   237                                                      
REMARK 465     PHE A   238                                                      
REMARK 465     THR A   239                                                      
REMARK 465     ALA A   240                                                      
REMARK 465     THR A   241                                                      
REMARK 465     GLN A   242                                                      
REMARK 465     PRO A   243                                                      
REMARK 465     GLU A   244                                                      
REMARK 465     VAL A   245                                                      
REMARK 465     ALA A   246                                                      
REMARK 465     ASP A   247                                                      
REMARK 465     TRP A   248                                                      
REMARK 465     SER A   249                                                      
REMARK 465     GLU A   250                                                      
REMARK 465     GLY A   251                                                      
REMARK 465     VAL A   252                                                      
REMARK 465     GLN A   253                                                      
REMARK 465     VAL A   254                                                      
REMARK 465     PRO A   255                                                      
REMARK 465     SER A   256                                                      
REMARK 465     VAL A   257                                                      
REMARK 465     PRO A   258                                                      
REMARK 465     ILE A   259                                                      
REMARK 465     GLN A   260                                                      
REMARK 465     GLN A   261                                                      
REMARK 465     PHE A   262                                                      
REMARK 465     PRO A   263                                                      
REMARK 465     THR A   264                                                      
REMARK 465     GLU A   265                                                      
REMARK 465     ASP A   266                                                      
REMARK 465     TRP A   267                                                      
REMARK 465     SER A   268                                                      
REMARK 465     ALA A   269                                                      
REMARK 465     GLN A   270                                                      
REMARK 465     PRO A   271                                                      
REMARK 465     ALA A   272                                                      
REMARK 465     THR A   273                                                      
REMARK 465     GLU A   274                                                      
REMARK 465     ASP A   275                                                      
REMARK 465     TRP A   276                                                      
REMARK 465     SER A   277                                                      
REMARK 465     ALA A   278                                                      
REMARK 465     ALA A   279                                                      
REMARK 465     PRO A   280                                                      
REMARK 465     THR A   281                                                      
REMARK 465     ALA A   282                                                      
REMARK 465     GLN A   283                                                      
REMARK 465     ALA A   284                                                      
REMARK 465     THR A   285                                                      
REMARK 465     GLU A   286                                                      
REMARK 465     TRP A   287                                                      
REMARK 465     VAL A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     THR A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     THR A   292                                                      
REMARK 465     GLU A   293                                                      
REMARK 465     TRP A   294                                                      
REMARK 465     SER A   295                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     VAL B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     ASN B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     ARG B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     THR B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     LYS B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     ALA B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     GLY B   235                                                      
REMARK 465     SER B   236                                                      
REMARK 465     SER B   237                                                      
REMARK 465     SER B   238                                                      
REMARK 465     GLY B   239                                                      
REMARK 465     LYS B   240                                                      
REMARK 465     ALA B   241                                                      
REMARK 465     THR B   242                                                      
REMARK 465     GLY B   243                                                      
REMARK 465     ASP B   244                                                      
REMARK 465     GLU B   245                                                      
REMARK 465     THR B   246                                                      
REMARK 465     GLY B   247                                                      
REMARK 465     ALA B   248                                                      
REMARK 465     LYS B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     GLU B   251                                                      
REMARK 465     ARG B   252                                                      
REMARK 465     ALA B   253                                                      
REMARK 465     ASP B   254                                                      
REMARK 465     GLY B   255                                                      
REMARK 465     TYR B   256                                                      
REMARK 465     GLU B   257                                                      
REMARK 465     PRO B   258                                                      
REMARK 465     PRO B   259                                                      
REMARK 465     VAL B   260                                                      
REMARK 465     GLN B   261                                                      
REMARK 465     GLU B   262                                                      
REMARK 465     SER B   263                                                      
REMARK 465     VAL B   264                                                      
REMARK 465     MET C     1                                                      
REMARK 465     VAL C     2                                                      
REMARK 465     ASP C     3                                                      
REMARK 465     ASP C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     ALA C     7                                                      
REMARK 465     ALA C     8                                                      
REMARK 465     GLY C     9                                                      
REMARK 465     GLY C    10                                                      
REMARK 465     PRO C    11                                                      
REMARK 465     GLY C    12                                                      
REMARK 465     GLY C    13                                                      
REMARK 465     PRO C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     GLY C    16                                                      
REMARK 465     PRO C    17                                                      
REMARK 465     GLY C    18                                                      
REMARK 465     MET C    19                                                      
REMARK 465     GLY C    20                                                      
REMARK 465     GLY C    21                                                      
REMARK 465     ARG C    22                                                      
REMARK 465     GLY C    23                                                      
REMARK 465     GLY C    24                                                      
REMARK 465     PHE C    25                                                      
REMARK 465     ARG C    26                                                      
REMARK 465     GLY C    27                                                      
REMARK 465     GLY C    28                                                      
REMARK 465     PHE C    29                                                      
REMARK 465     GLY C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     GLY C    32                                                      
REMARK 465     ILE C    33                                                      
REMARK 465     ARG C    34                                                      
REMARK 465     GLY C    35                                                      
REMARK 465     CYS C    36                                                      
REMARK 465     GLY C    37                                                      
REMARK 465     ARG C   264                                                      
REMARK 465     VAL C   265                                                      
REMARK 465     SER C   266                                                      
REMARK 465     VAL C   267                                                      
REMARK 465     GLN C   268                                                      
REMARK 465     ARG C   269                                                      
REMARK 465     THR C   270                                                      
REMARK 465     GLN C   271                                                      
REMARK 465     ALA C   272                                                      
REMARK 465     PRO C   273                                                      
REMARK 465     ALA C   274                                                      
REMARK 465     VAL C   275                                                      
REMARK 465     ALA C   276                                                      
REMARK 465     THR C   277                                                      
REMARK 465     THR C   278                                                      
REMARK 465     GLY D   228                                                      
REMARK 465     GLY D   229                                                      
REMARK 465     LYS D   230                                                      
REMARK 465     PRO D   231                                                      
REMARK 465     GLU D   232                                                      
REMARK 465     PRO D   233                                                      
REMARK 465     PRO D   234                                                      
REMARK 465     ALA D   235                                                      
REMARK 465     MET D   236                                                      
REMARK 465     PRO D   237                                                      
REMARK 465     GLN D   238                                                      
REMARK 465     PRO D   239                                                      
REMARK 465     VAL D   240                                                      
REMARK 465     PRO D   241                                                      
REMARK 465     THR D   242                                                      
REMARK 465     ALA D   243                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     GLU F     3                                                      
REMARK 465     TRP F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     THR F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     ALA F     8                                                      
REMARK 465     PRO F     9                                                      
REMARK 465     ALA F    10                                                      
REMARK 465     VAL F    11                                                      
REMARK 465     ALA F    12                                                      
REMARK 465     GLU F    13                                                      
REMARK 465     ARG G   238                                                      
REMARK 465     ALA G   239                                                      
REMARK 465     SER G   240                                                      
REMARK 465     THR G   241                                                      
REMARK 465     SER G   242                                                      
REMARK 465     LYS G   243                                                      
REMARK 465     SER G   244                                                      
REMARK 465     GLU G   245                                                      
REMARK 465     SER G   246                                                      
REMARK 465     SER G   247                                                      
REMARK 465     GLN G   248                                                      
REMARK 465     LYS G   249                                                      
REMARK 465     MET H     1                                                      
REMARK 465     PHE H     2                                                      
REMARK 465     SER H     3                                                      
REMARK 465     SER H     4                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LYS I   208                                                      
REMARK 465     MET J     1                                                      
REMARK 465     PRO J     2                                                      
REMARK 465     VAL J     3                                                      
REMARK 465     ALA J     4                                                      
REMARK 465     ARG J     5                                                      
REMARK 465     SER J     6                                                      
REMARK 465     ASP J   189                                                      
REMARK 465     ASP J   190                                                      
REMARK 465     GLU J   191                                                      
REMARK 465     GLU J   192                                                      
REMARK 465     GLU J   193                                                      
REMARK 465     ASP J   194                                                      
REMARK 465     PRO K    99                                                      
REMARK 465     GLU K   100                                                      
REMARK 465     THR K   101                                                      
REMARK 465     GLY K   102                                                      
REMARK 465     ARG K   103                                                      
REMARK 465     PRO K   104                                                      
REMARK 465     ARG K   105                                                      
REMARK 465     PRO K   106                                                      
REMARK 465     LYS K   107                                                      
REMARK 465     GLY K   108                                                      
REMARK 465     LEU K   109                                                      
REMARK 465     GLU K   110                                                      
REMARK 465     GLY K   111                                                      
REMARK 465     GLU K   112                                                      
REMARK 465     ARG K   113                                                      
REMARK 465     PRO K   114                                                      
REMARK 465     ALA K   115                                                      
REMARK 465     ARG K   116                                                      
REMARK 465     LEU K   117                                                      
REMARK 465     THR K   118                                                      
REMARK 465     ARG K   119                                                      
REMARK 465     GLY K   120                                                      
REMARK 465     GLU K   121                                                      
REMARK 465     ALA K   122                                                      
REMARK 465     ASP K   123                                                      
REMARK 465     ARG K   124                                                      
REMARK 465     ASP K   125                                                      
REMARK 465     THR K   126                                                      
REMARK 465     TYR K   127                                                      
REMARK 465     ARG K   128                                                      
REMARK 465     ARG K   129                                                      
REMARK 465     SER K   130                                                      
REMARK 465     ALA K   131                                                      
REMARK 465     VAL K   132                                                      
REMARK 465     PRO K   133                                                      
REMARK 465     PRO K   134                                                      
REMARK 465     GLY K   135                                                      
REMARK 465     ALA K   136                                                      
REMARK 465     ASP K   137                                                      
REMARK 465     LYS K   138                                                      
REMARK 465     LYS K   139                                                      
REMARK 465     ALA K   140                                                      
REMARK 465     GLU K   141                                                      
REMARK 465     ALA K   142                                                      
REMARK 465     GLY K   143                                                      
REMARK 465     ALA K   144                                                      
REMARK 465     GLY K   145                                                      
REMARK 465     SER K   146                                                      
REMARK 465     ALA K   147                                                      
REMARK 465     THR K   148                                                      
REMARK 465     GLU K   149                                                      
REMARK 465     PHE K   150                                                      
REMARK 465     GLN K   151                                                      
REMARK 465     PHE K   152                                                      
REMARK 465     ARG K   153                                                      
REMARK 465     GLY K   154                                                      
REMARK 465     GLY K   155                                                      
REMARK 465     PHE K   156                                                      
REMARK 465     GLY K   157                                                      
REMARK 465     ARG K   158                                                      
REMARK 465     GLY K   159                                                      
REMARK 465     ARG K   160                                                      
REMARK 465     GLY K   161                                                      
REMARK 465     GLN K   162                                                      
REMARK 465     PRO K   163                                                      
REMARK 465     PRO K   164                                                      
REMARK 465     GLN K   165                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ALA M     2                                                      
REMARK 465     GLU M     3                                                      
REMARK 465     GLU M     4                                                      
REMARK 465     GLY M     5                                                      
REMARK 465     ILE M     6                                                      
REMARK 465     ALA M     7                                                      
REMARK 465     ALA M     8                                                      
REMARK 465     MET N     1                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     PRO O     3                                                      
REMARK 465     ARG O     4                                                      
REMARK 465     LYS O     5                                                      
REMARK 465     GLY O     6                                                      
REMARK 465     LYS O     7                                                      
REMARK 465     GLU O     8                                                      
REMARK 465     LYS O     9                                                      
REMARK 465     LYS O    10                                                      
REMARK 465     GLU O    11                                                      
REMARK 465     GLU O    12                                                      
REMARK 465     GLN O    13                                                      
REMARK 465     VAL O    14                                                      
REMARK 465     ILE O    15                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     GLU P     3                                                      
REMARK 465     PRO P   131                                                      
REMARK 465     GLY P   132                                                      
REMARK 465     ILE P   133                                                      
REMARK 465     GLY P   134                                                      
REMARK 465     ALA P   135                                                      
REMARK 465     THR P   136                                                      
REMARK 465     HIS P   137                                                      
REMARK 465     SER P   138                                                      
REMARK 465     SER P   139                                                      
REMARK 465     ARG P   140                                                      
REMARK 465     PHE P   141                                                      
REMARK 465     ILE P   142                                                      
REMARK 465     PRO P   143                                                      
REMARK 465     LEU P   144                                                      
REMARK 465     LYS P   145                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     PRO Q     2                                                      
REMARK 465     SER Q     3                                                      
REMARK 465     LYS Q     4                                                      
REMARK 465     GLY Q     5                                                      
REMARK 465     ASN R   127                                                      
REMARK 465     PHE R   128                                                      
REMARK 465     LYS R   129                                                      
REMARK 465     THR R   130                                                      
REMARK 465     PRO R   131                                                      
REMARK 465     ARG R   132                                                      
REMARK 465     GLY R   133                                                      
REMARK 465     ALA R   134                                                      
REMARK 465     VAL R   135                                                      
REMARK 465     MET S     1                                                      
REMARK 465     SER S     2                                                      
REMARK 465     LEU S     3                                                      
REMARK 465     VAL S     4                                                      
REMARK 465     ILE S     5                                                      
REMARK 465     GLY S   143                                                      
REMARK 465     ARG S   144                                                      
REMARK 465     THR S   145                                                      
REMARK 465     VAL S   146                                                      
REMARK 465     GLY S   147                                                      
REMARK 465     VAL S   148                                                      
REMARK 465     SER S   149                                                      
REMARK 465     LYS S   150                                                      
REMARK 465     LYS S   151                                                      
REMARK 465     LYS S   152                                                      
REMARK 465     MET T     1                                                      
REMARK 465     PRO T     2                                                      
REMARK 465     GLY T     3                                                      
REMARK 465     HIS T   145                                                      
REMARK 465     MET U     1                                                      
REMARK 465     ALA U     2                                                      
REMARK 465     PHE U     3                                                      
REMARK 465     LYS U     4                                                      
REMARK 465     ASP U     5                                                      
REMARK 465     THR U     6                                                      
REMARK 465     GLY U     7                                                      
REMARK 465     LYS U     8                                                      
REMARK 465     THR U     9                                                      
REMARK 465     PRO U    10                                                      
REMARK 465     VAL U    11                                                      
REMARK 465     GLU U    12                                                      
REMARK 465     PRO U    13                                                      
REMARK 465     GLU U    14                                                      
REMARK 465     VAL U    15                                                      
REMARK 465     PHE V    83                                                      
REMARK 465     MET W     1                                                      
REMARK 465     SER X   143                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASN Y     2                                                      
REMARK 465     LYS Y   129                                                      
REMARK 465     LYS Y   130                                                      
REMARK 465     PRO Y   131                                                      
REMARK 465     LYS Y   132                                                      
REMARK 465     GLU Y   133                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     PRO Z     2                                                      
REMARK 465     PRO Z     3                                                      
REMARK 465     LYS Z     4                                                      
REMARK 465     ASP Z     5                                                      
REMARK 465     ASP Z     6                                                      
REMARK 465     LYS Z     7                                                      
REMARK 465     LYS Z     8                                                      
REMARK 465     LYS Z     9                                                      
REMARK 465     LYS Z    10                                                      
REMARK 465     ASP Z    11                                                      
REMARK 465     ALA Z    12                                                      
REMARK 465     GLY Z    13                                                      
REMARK 465     LYS Z    14                                                      
REMARK 465     SER Z    15                                                      
REMARK 465     ALA Z    16                                                      
REMARK 465     LYS Z    17                                                      
REMARK 465     LYS Z    18                                                      
REMARK 465     ASP Z    19                                                      
REMARK 465     LYS Z    20                                                      
REMARK 465     ASP Z    21                                                      
REMARK 465     PRO Z    22                                                      
REMARK 465     VAL Z    23                                                      
REMARK 465     ASN Z    24                                                      
REMARK 465     LYS Z    25                                                      
REMARK 465     SER Z    26                                                      
REMARK 465     GLY Z    27                                                      
REMARK 465     GLY Z    28                                                      
REMARK 465     LYS Z    29                                                      
REMARK 465     ALA Z    30                                                      
REMARK 465     LYS Z    31                                                      
REMARK 465     LYS Z    32                                                      
REMARK 465     LYS Z    33                                                      
REMARK 465     LYS Z    34                                                      
REMARK 465     TRP Z    35                                                      
REMARK 465     SER Z    36                                                      
REMARK 465     LYS Z    37                                                      
REMARK 465     GLY Z    38                                                      
REMARK 465     LYS Z    39                                                      
REMARK 465     VAL Z    40                                                      
REMARK 465     GLY Z   116                                                      
REMARK 465     ASP Z   117                                                      
REMARK 465     ALA Z   118                                                      
REMARK 465     PRO Z   119                                                      
REMARK 465     ALA Z   120                                                      
REMARK 465     ALA Z   121                                                      
REMARK 465     GLY Z   122                                                      
REMARK 465     GLU Z   123                                                      
REMARK 465     ASP Z   124                                                      
REMARK 465     ALA Z   125                                                      
REMARK 465     MET a     1                                                      
REMARK 465     PRO a   109                                                      
REMARK 465     PRO a   110                                                      
REMARK 465     PRO a   111                                                      
REMARK 465     PRO a   112                                                      
REMARK 465     LYS a   113                                                      
REMARK 465     PRO a   114                                                      
REMARK 465     MET a   115                                                      
REMARK 465     MET c     1                                                      
REMARK 465     ASP c     2                                                      
REMARK 465     THR c     3                                                      
REMARK 465     SER c     4                                                      
REMARK 465     ARG c    69                                                      
REMARK 465     MET d     1                                                      
REMARK 465     GLY d     2                                                      
REMARK 465     HIS d     3                                                      
REMARK 465     MET e     1                                                      
REMARK 465     GLN e     2                                                      
REMARK 465     LEU e     3                                                      
REMARK 465     PHE e     4                                                      
REMARK 465     VAL e     5                                                      
REMARK 465     ARG e     6                                                      
REMARK 465     ALA e     7                                                      
REMARK 465     GLN e     8                                                      
REMARK 465     GLU e     9                                                      
REMARK 465     LEU e    10                                                      
REMARK 465     HIS e    11                                                      
REMARK 465     THR e    12                                                      
REMARK 465     LEU e    13                                                      
REMARK 465     GLU e    14                                                      
REMARK 465     VAL e    15                                                      
REMARK 465     THR e    16                                                      
REMARK 465     GLY e    17                                                      
REMARK 465     ARG e    18                                                      
REMARK 465     GLU e    19                                                      
REMARK 465     THR e    20                                                      
REMARK 465     VAL e    21                                                      
REMARK 465     ALA e    22                                                      
REMARK 465     GLN e    23                                                      
REMARK 465     ILE e    24                                                      
REMARK 465     LYS e    25                                                      
REMARK 465     ALA e    26                                                      
REMARK 465     HIS e    27                                                      
REMARK 465     VAL e    28                                                      
REMARK 465     ALA e    29                                                      
REMARK 465     SER e    30                                                      
REMARK 465     LEU e    31                                                      
REMARK 465     GLU e    32                                                      
REMARK 465     GLY e    33                                                      
REMARK 465     ILE e    34                                                      
REMARK 465     ALA e    35                                                      
REMARK 465     PRO e    36                                                      
REMARK 465     GLU e    37                                                      
REMARK 465     ASP e    38                                                      
REMARK 465     GLN e    39                                                      
REMARK 465     VAL e    40                                                      
REMARK 465     VAL e    41                                                      
REMARK 465     LEU e    42                                                      
REMARK 465     LEU e    43                                                      
REMARK 465     ALA e    44                                                      
REMARK 465     GLY e    45                                                      
REMARK 465     THR e    46                                                      
REMARK 465     PRO e    47                                                      
REMARK 465     LEU e    48                                                      
REMARK 465     GLU e    49                                                      
REMARK 465     ASP e    50                                                      
REMARK 465     GLU e    51                                                      
REMARK 465     ALA e    52                                                      
REMARK 465     THR e    53                                                      
REMARK 465     LEU e    54                                                      
REMARK 465     GLY e    55                                                      
REMARK 465     GLN e    56                                                      
REMARK 465     CYS e    57                                                      
REMARK 465     GLY e    58                                                      
REMARK 465     VAL e    59                                                      
REMARK 465     GLU e    60                                                      
REMARK 465     ALA e    61                                                      
REMARK 465     LEU e    62                                                      
REMARK 465     SER e    63                                                      
REMARK 465     THR e    64                                                      
REMARK 465     LEU e    65                                                      
REMARK 465     GLU e    66                                                      
REMARK 465     VAL e    67                                                      
REMARK 465     ALA e    68                                                      
REMARK 465     GLY e    69                                                      
REMARK 465     ARG e    70                                                      
REMARK 465     MET e    71                                                      
REMARK 465     LEU e    72                                                      
REMARK 465     GLY e    73                                                      
REMARK 465     GLY e    74                                                      
REMARK 465     MET f     1                                                      
REMARK 465     GLN f     2                                                      
REMARK 465     ILE f     3                                                      
REMARK 465     PHE f     4                                                      
REMARK 465     VAL f     5                                                      
REMARK 465     LYS f     6                                                      
REMARK 465     THR f     7                                                      
REMARK 465     LEU f     8                                                      
REMARK 465     THR f     9                                                      
REMARK 465     GLY f    10                                                      
REMARK 465     LYS f    11                                                      
REMARK 465     THR f    12                                                      
REMARK 465     ILE f    13                                                      
REMARK 465     THR f    14                                                      
REMARK 465     LEU f    15                                                      
REMARK 465     GLU f    16                                                      
REMARK 465     VAL f    17                                                      
REMARK 465     GLU f    18                                                      
REMARK 465     PRO f    19                                                      
REMARK 465     SER f    20                                                      
REMARK 465     ASP f    21                                                      
REMARK 465     THR f    22                                                      
REMARK 465     ILE f    23                                                      
REMARK 465     GLU f    24                                                      
REMARK 465     ASN f    25                                                      
REMARK 465     VAL f    26                                                      
REMARK 465     LYS f    27                                                      
REMARK 465     ALA f    28                                                      
REMARK 465     LYS f    29                                                      
REMARK 465     ILE f    30                                                      
REMARK 465     GLN f    31                                                      
REMARK 465     ASP f    32                                                      
REMARK 465     LYS f    33                                                      
REMARK 465     GLU f    34                                                      
REMARK 465     GLY f    35                                                      
REMARK 465     ILE f    36                                                      
REMARK 465     PRO f    37                                                      
REMARK 465     PRO f    38                                                      
REMARK 465     ASP f    39                                                      
REMARK 465     GLN f    40                                                      
REMARK 465     GLN f    41                                                      
REMARK 465     ARG f    42                                                      
REMARK 465     LEU f    43                                                      
REMARK 465     ILE f    44                                                      
REMARK 465     PHE f    45                                                      
REMARK 465     ALA f    46                                                      
REMARK 465     GLY f    47                                                      
REMARK 465     LYS f    48                                                      
REMARK 465     GLN f    49                                                      
REMARK 465     LEU f    50                                                      
REMARK 465     GLU f    51                                                      
REMARK 465     ASP f    52                                                      
REMARK 465     GLY f    53                                                      
REMARK 465     ARG f    54                                                      
REMARK 465     THR f    55                                                      
REMARK 465     LEU f    56                                                      
REMARK 465     SER f    57                                                      
REMARK 465     ASP f    58                                                      
REMARK 465     TYR f    59                                                      
REMARK 465     ASN f    60                                                      
REMARK 465     ILE f    61                                                      
REMARK 465     GLN f    62                                                      
REMARK 465     LYS f    63                                                      
REMARK 465     GLU f    64                                                      
REMARK 465     SER f    65                                                      
REMARK 465     THR f    66                                                      
REMARK 465     LEU f    67                                                      
REMARK 465     HIS f    68                                                      
REMARK 465     LEU f    69                                                      
REMARK 465     VAL f    70                                                      
REMARK 465     LEU f    71                                                      
REMARK 465     ARG f    72                                                      
REMARK 465     LEU f    73                                                      
REMARK 465     ARG f    74                                                      
REMARK 465     GLY f    75                                                      
REMARK 465     GLY f    76                                                      
REMARK 465     ALA f    77                                                      
REMARK 465     LYS f    78                                                      
REMARK 465     LYS f    79                                                      
REMARK 465     ARG f    80                                                      
REMARK 465     LYS f    81                                                      
REMARK 465     PRO f   153                                                      
REMARK 465     GLU f   154                                                      
REMARK 465     ASP f   155                                                      
REMARK 465     LYS f   156                                                      
REMARK 465     MET g     1                                                      
REMARK 465     GLY g   315                                                      
REMARK 465     THR g   316                                                      
REMARK 465     ARG g   317                                                      
REMARK 465       U i   681                                                      
REMARK 465       G i   682                                                      
REMARK 465       G i   700                                                      
REMARK 465       G i   701                                                      
REMARK 465       U i   702                                                      
REMARK 465       C i   703                                                      
REMARK 465       C i   704                                                      
REMARK 465       G i   705                                                      
REMARK 465       C i   706                                                      
REMARK 465       C i   707                                                      
REMARK 465       G i   708                                                      
REMARK 465       C i   709                                                      
REMARK 465       G i   710                                                      
REMARK 465       A i   711                                                      
REMARK 465       G i   712                                                      
REMARK 465       G i   713                                                      
REMARK 465       C i   714                                                      
REMARK 465       G i   715                                                      
REMARK 465       A i   716                                                      
REMARK 465       G i   717                                                      
REMARK 465       C i   718                                                      
REMARK 465       C i   736                                                      
REMARK 465       C i   737                                                      
REMARK 465       U i   745                                                      
REMARK 465       C i   746                                                      
REMARK 465       G i   747                                                      
REMARK 465       G i   748                                                      
REMARK 465       C i   749                                                      
REMARK 465       G i   750                                                      
REMARK 465       C i   751                                                      
REMARK 465       C i   752                                                      
REMARK 465       C i   753                                                      
REMARK 465       C i   754                                                      
REMARK 465       C i   755                                                      
REMARK 465       U i   756                                                      
REMARK 465       C i   757                                                      
REMARK 465       G i   758                                                      
REMARK 465       A i   759                                                      
REMARK 465       U i   760                                                      
REMARK 465       G i   761                                                      
REMARK 465       C i   762                                                      
REMARK 465       U i   763                                                      
REMARK 465       C i   764                                                      
REMARK 465       U i   765                                                      
REMARK 465       U i   766                                                      
REMARK 465       A i   767                                                      
REMARK 465       G i   768                                                      
REMARK 465       C i   769                                                      
REMARK 465       U i   770                                                      
REMARK 465       G i   771                                                      
REMARK 465       A i   772                                                      
REMARK 465       G i   773                                                      
REMARK 465       U i   774                                                      
REMARK 465       G i   775                                                      
REMARK 465       U i   776                                                      
REMARK 465       C i   777                                                      
REMARK 465       C i   778                                                      
REMARK 465       C i   779                                                      
REMARK 465       G i   780                                                      
REMARK 465       C i   781                                                      
REMARK 465       G i   782                                                      
REMARK 465       G i   783                                                      
REMARK 465       G i   784                                                      
REMARK 465       G i   785                                                      
REMARK 465       C i   786                                                      
REMARK 465       C i   787                                                      
REMARK 465     MET l     1                                                      
REMARK 465     SER l     2                                                      
REMARK 465     ALA l     3                                                      
REMARK 465     ILE l     4                                                      
REMARK 465     GLN l     5                                                      
REMARK 465     ASN l     6                                                      
REMARK 465     LEU l     7                                                      
REMARK 465     HIS l     8                                                      
REMARK 465     SER l     9                                                      
REMARK 465     PHE l    10                                                      
REMARK 465     ASP l    11                                                      
REMARK 465     PRO l    12                                                      
REMARK 465     PHE l    13                                                      
REMARK 465     ALA l    14                                                      
REMARK 465     ASP l    15                                                      
REMARK 465     ALA l    16                                                      
REMARK 465     SER l    17                                                      
REMARK 465     LYS l    18                                                      
REMARK 465     GLY l    19                                                      
REMARK 465     ASP l    20                                                      
REMARK 465     ASP l    21                                                      
REMARK 465     LEU l    22                                                      
REMARK 465     LEU l    23                                                      
REMARK 465     PRO l    24                                                      
REMARK 465     ALA l    25                                                      
REMARK 465     GLY l    26                                                      
REMARK 465     THR l    27                                                      
REMARK 465     GLU l    28                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LEU M  52    CG   CD1  CD2                                       
REMARK 470     CYS M  69    SG                                                  
REMARK 470     LYS M  99    CG   CD   CE   NZ                                   
REMARK 470       U i 128    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       U i 128    N3   C4   O4   C5   C6                              
REMARK 470       C i 129    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 129    N3   C4   N4   C5   C6                              
REMARK 470       G i 130    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 130    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 130    C4                                                  
REMARK 470       C i 131    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 131    N3   C4   N4   C5   C6                              
REMARK 470       U i 132    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       U i 132    N3   C4   O4   C5   C6                              
REMARK 470       C i 133    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 133    N3   C4   N4   C5   C6                              
REMARK 470       C i 134    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 134    N3   C4   N4   C5   C6                              
REMARK 470       U i 135    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       U i 135    N3   C4   O4   C5   C6                              
REMARK 470       C i 136    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 136    N3   C4   N4   C5   C6                              
REMARK 470       U i 137    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       U i 137    N3   C4   O4   C5   C6                              
REMARK 470       C i 138    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 138    N3   C4   N4   C5   C6                              
REMARK 470       G i 242    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 242    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 242    C4                                                  
REMARK 470       C i 243    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 243    N3   C4   N4   C5   C6                              
REMARK 470       C i 244    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 244    N3   C4   N4   C5   C6                              
REMARK 470       U i 245    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       U i 245    N3   C4   O4   C5   C6                              
REMARK 470       C i 246    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 246    N3   C4   N4   C5   C6                              
REMARK 470       C i 247    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 247    N3   C4   N4   C5   C6                              
REMARK 470       C i 248    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 248    N3   C4   N4   C5   C6                              
REMARK 470       C i 249    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 249    N3   C4   N4   C5   C6                              
REMARK 470       G i 250    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 250    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 250    C4                                                  
REMARK 470       C i 251    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 251    N3   C4   N4   C5   C6                              
REMARK 470       C i 252    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 252    N3   C4   N4   C5   C6                              
REMARK 470       G i 253    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 253    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 253    C4                                                  
REMARK 470       G i 254    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 254    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 254    C4                                                  
REMARK 470       C i 255    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 255    N3   C4   N4   C5   C6                              
REMARK 470       C i 256    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 256    N3   C4   N4   C5   C6                              
REMARK 470       G i 257    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 257    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 257    C4                                                  
REMARK 470       G i 258    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 258    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 258    C4                                                  
REMARK 470       G i 259    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 259    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 259    C4                                                  
REMARK 470       G i 260    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 260    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 260    C4                                                  
REMARK 470       G i 261    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 261    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 261    C4                                                  
REMARK 470       G i 262    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 262    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 262    C4                                                  
REMARK 470       G i 263    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 263    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 263    C4                                                  
REMARK 470       U i 264    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       U i 264    N3   C4   O4   C5   C6                              
REMARK 470       G i 265    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 265    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 265    C4                                                  
REMARK 470       G i 266    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 266    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 266    C4                                                  
REMARK 470       G i 267    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 267    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 267    C4                                                  
REMARK 470       G i 268    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 268    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 268    C4                                                  
REMARK 470       C i 269    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 269    N3   C4   N4   C5   C6                              
REMARK 470       U i 692    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       U i 692    N3   C4   O4   C5   C6                              
REMARK 470       A i 693    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       A i 693    C5   C6   N6   N1   C2   N3   C4                    
REMARK 470       G i 694    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 694    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 694    C4                                                  
REMARK 470       C i 695    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 695    N3   C4   N4   C5   C6                              
REMARK 470       G i 696    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 696    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 696    C4                                                  
REMARK 470       G i 697    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 697    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 697    C4                                                  
REMARK 470       G i 698    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 698    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 698    C4                                                  
REMARK 470       C i 699    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 699    N3   C4   N4   C5   C6                              
REMARK 470       C i 719    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 719    N3   C4   N4   C5   C6                              
REMARK 470       A i 720    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       A i 720    C5   C6   N6   N1   C2   N3   C4                    
REMARK 470       C i 721    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 721    N3   C4   N4   C5   C6                              
REMARK 470       C i 722    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 722    N3   C4   N4   C5   C6                              
REMARK 470       G i 723    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i 723    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i 723    C4                                                  
REMARK 470       C i 724    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i 724    N3   C4   N4   C5   C6                              
REMARK 470       C i1756    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i1756    N3   C4   N4   C5   C6                              
REMARK 470       G i1757    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i1757    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i1757    C4                                                  
REMARK 470       G i1758    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i1758    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i1758    C4                                                  
REMARK 470       C i1759    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i1759    N3   C4   N4   C5   C6                              
REMARK 470       C i1760    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i1760    N3   C4   N4   C5   C6                              
REMARK 470       C i1761    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i1761    N3   C4   N4   C5   C6                              
REMARK 470       A i1762    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       A i1762    C5   C6   N6   N1   C2   N3   C4                    
REMARK 470       C i1763    O4'  C2'  O2'  C1'  N1   C2   O2                    
REMARK 470       C i1763    N3   C4   N4   C5   C6                              
REMARK 470       G i1764    O4'  C2'  O2'  C1'  N9   C8   N7                    
REMARK 470       G i1764    C5   C6   O6   N1   C2   N2   N3                    
REMARK 470       G i1764    C4                                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   ND2  ASN A   110     O2'    G i  1347              0.50            
REMARK 500   OD1  ASN A   110     C3'    G i  1347              0.61            
REMARK 500   CE   LYS J    66     O5'    U i   688              0.67            
REMARK 500   N3     A i    61     C2'    A i   326              0.67            
REMARK 500   C6     A i    60     C5'    A i   326              0.77            
REMARK 500   C8     A i  1825     C2     A i  1845              0.81            
REMARK 500   NZ   LYS J    66     O5'    U i   688              0.86            
REMARK 500   NH2  ARG F   135     OD1  ASP O    67              0.89            
REMARK 500   CE   LYS J    66     C5'    U i   688              0.92            
REMARK 500   C6     A i    60     C4'    A i   326              0.97            
REMARK 500   CG1  VAL G   184     OP1    U i   305              0.98            
REMARK 500   CD   LYS J    66     C5'    U i   688              1.02            
REMARK 500   O6     G i  1206     N7     G i  1207              1.02            
REMARK 500   N2     G i   689     N2     G i   727              1.05            
REMARK 500   CG1  ILE A   112     O2'    U i  1346              1.09            
REMARK 500   CG   ASN A   110     O2'    G i  1347              1.11            
REMARK 500   OD1  ASN A   110     O3'    G i  1347              1.11            
REMARK 500   N1     A i    60     C5'    A i   326              1.11            
REMARK 500   O    PRO A   105     C2     A i  1374              1.13            
REMARK 500   NH2  ARG F   135     CG   ASP O    67              1.14            
REMARK 500   NH1  ARG G   183     OP2    G i   307              1.15            
REMARK 500   CB   ARG W   118     OP1    C i   731              1.16            
REMARK 500   C1'    A i    61     O2'    A i   326              1.20            
REMARK 500   C8     A i  1825     N3     A i  1845              1.22            
REMARK 500   C4     A i    61     C2'    A i   326              1.24            
REMARK 500   N2     G i   184     O2     U i   211              1.28            
REMARK 500   CE1  PHE C   246     CB   ARG V    15              1.30            
REMARK 500   C6     G i  1206     C8     G i  1207              1.32            
REMARK 500   N7     G i  1843     ND2  ASN l    70              1.32            
REMARK 500   CB   TRP D   192     CA   GLY D   196              1.32            
REMARK 500   O    ILE L     4     N    THR L     6              1.32            
REMARK 500   CG2  ILE A    48     CE   MET R   105              1.33            
REMARK 500   O4'    A i  1825     C6     A i  1845              1.33            
REMARK 500   O    LYS G    64     SG   CYS G   100              1.33            
REMARK 500   C4     A i    61     C3'    A i   326              1.33            
REMARK 500   CA   ARG W   118     OP1    C i   731              1.34            
REMARK 500   O    GLU D    31     NH1  ARG D    54              1.34            
REMARK 500   OE1  GLN N    62     CE2  PHE N    65              1.34            
REMARK 500   O2'    A i  1825     C4'    C i  1846              1.34            
REMARK 500   N    GLY A   106     C6     A i  1374              1.35            
REMARK 500   O    ASP B    77     N    VAL B    79              1.35            
REMARK 500   O    LYS D   108     CD1  LEU D   113              1.36            
REMARK 500   C5     A i    61     O3'    A i   326              1.36            
REMARK 500   N1     G i   689     N1     G i   727              1.37            
REMARK 500   NH2  ARG V    71     CB   ALA b     4              1.37            
REMARK 500   CE   LYS X   124     O    ASN X   127              1.37            
REMARK 500   CG   ASN A   110     C2'    G i  1347              1.37            
REMARK 500   CB   ILE A   112     O2'    U i  1346              1.37            
REMARK 500   CD1  LEU B    48     OD2  ASP O    46              1.39            
REMARK 500   O    HIS L    94     CB   PHE L   102              1.39            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     819 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   NZ   LYS I   125     N    LYS l    56     4555     0.47            
REMARK 500   CE1  PHE e   123     C3'    G i  1758     3564     0.56            
REMARK 500   NE2  GLN G   155     N    ARG K    98     2665     0.61            
REMARK 500   NE   ARG S   108     OP1    C i   724     5664     0.68            
REMARK 500   N3     C i   533     C5'    C i   136     3564     0.71            
REMARK 500   CD   ARG S   108     O5'    C i   724     5664     0.74            
REMARK 500   N1     C i   533     C4'    C i   136     3564     0.77            
REMARK 500   CZ   ARG S   108     OP1    C i   724     5664     0.80            
REMARK 500   C5'    C i   136     C2     C i   533     2665     0.84            
REMARK 500   CB   ALA I   127     O    ASP l    52     4555     0.84            
REMARK 500   O5'    C i   136     N3     C i   533     2665     0.91            
REMARK 500   C2     C i   533     C4'    C i   136     3564     0.91            
REMARK 500   O5'    C i  1761     NZ   LYS e   125     2665     0.92            
REMARK 500   CG   ARG S   108     C5'    C i   724     5664     0.95            
REMARK 500   NZ   LYS I   125     C    ASP l    55     4555     0.97            
REMARK 500   OP2    C i  1760     N    LYS e   125     2665     0.97            
REMARK 500   NH2  ARG I   200     OP2    G i  1036     4555     0.98            
REMARK 500   OP2    U i   137     O2     U i   532     2665     0.99            
REMARK 500   CB   ARG K    98     CD   GLN G   155     3564     1.08            
REMARK 500   CG2  THR B    55     OP1    G i   271     4555     1.09            
REMARK 500   NE   ARG S   108     P      C i   724     5664     1.09            
REMARK 500   CD   GLU S   112     OP1    C i   725     5664     1.09            
REMARK 500   C3'    C i   136     C1'    C i   533     2665     1.09            
REMARK 500   CD   ARG S   108     C5'    C i   724     5664     1.11            
REMARK 500   CG   GLN G   155     CA   ARG K    98     2665     1.12            
REMARK 500   CD   GLN G   155     CA   ARG K    98     2665     1.14            
REMARK 500   O5'    C i  1759     CG   PHE e   123     2665     1.17            
REMARK 500   CG   ARG K    98     CB   GLN G   155     3564     1.18            
REMARK 500   CZ   TYR G   156     NH2  ARG K    98     2665     1.19            
REMARK 500   NH2  ARG G   154     NH2  ARG K    96     2665     1.21            
REMARK 500   CE   LYS I   125     N    LYS l    56     4555     1.23            
REMARK 500   CB   ARG K    98     CG   GLN G   155     3564     1.26            
REMARK 500   C5'    C i  1761     NZ   LYS e   125     2665     1.26            
REMARK 500   NH1  ARG K    98     C    GLN G   155     3564     1.27            
REMARK 500   N1     C i   533     C3'    C i   136     3564     1.27            
REMARK 500   OP1    U i   137     N3     U i   532     2665     1.27            
REMARK 500   C3'    G i  1758     CZ   PHE e   123     2665     1.28            
REMARK 500   OE1  GLN G   155     CB   ARG K    98     2665     1.29            
REMARK 500   CZ   ARG I   200     OP2    G i  1036     4555     1.31            
REMARK 500   O    ALA C    40     C5'    G i  1764     3564     1.35            
REMARK 500   NH1  ARG K    98     O    GLN G   155     3564     1.36            
REMARK 500   CE   LYS I   125     CA   LYS l    56     4555     1.37            
REMARK 500   OP1    C i  1760     C    LYS e   125     2665     1.38            
REMARK 500   OE2  GLU S   112     P      C i   725     5664     1.40            
REMARK 500   O5'    C i  1761     CE   LYS e   125     2665     1.40            
REMARK 500   CG   GLU S   112     OP1    C i   725     5664     1.41            
REMARK 500   P      C i  1760     CA   LYS e   125     2665     1.41            
REMARK 500   NH2  ARG I   200     P      G i  1036     4555     1.42            
REMARK 500   OE2  GLU S   112     OP1    C i   725     5664     1.43            
REMARK 500   O4'    C i   533     C3'    C i   136     3564     1.44            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     168 SYMMETRY CONTACTS                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    GLU A 209   C     GLU A 209   O      -0.228                       
REMARK 500    TYR B 133   CB    TYR B 133   CG     -0.105                       
REMARK 500    TYR B 155   CB    TYR B 155   CG     -0.136                       
REMARK 500    GLY B 233   C     GLY B 233   O      -0.230                       
REMARK 500    PRO C  47   CD    PRO C  47   N       0.127                       
REMARK 500    PRO C  72   CD    PRO C  72   N       0.090                       
REMARK 500    LYS C  93   C     ILE C  94   N      -0.159                       
REMARK 500    PRO C 193   CD    PRO C 193   N       0.113                       
REMARK 500    PRO C 195   CD    PRO C 195   N       0.084                       
REMARK 500    THR C 263   C     THR C 263   O      -0.228                       
REMARK 500    GLN D   4   N     GLN D   4   CA     -0.168                       
REMARK 500    GLU D  20   CG    GLU D  20   CD      0.096                       
REMARK 500    LEU D  96   C     CYS D  97   N       0.213                       
REMARK 500    LYS D 227   C     LYS D 227   O      -0.230                       
REMARK 500    PRO E 150   CD    PRO E 150   N       0.088                       
REMARK 500    GLY E 263   C     GLY E 263   O      -0.232                       
REMARK 500    GLY E 263   C     GLY E 263   OXT    -0.229                       
REMARK 500    PRO F 108   CD    PRO F 108   N       0.102                       
REMARK 500    ARG F 204   C     ARG F 204   O      -0.226                       
REMARK 500    ARG F 204   C     ARG F 204   OXT    -0.231                       
REMARK 500    VAL G  36   CA    VAL G  36   CB     -0.168                       
REMARK 500    VAL G  36   CB    VAL G  36   CG1    -0.185                       
REMARK 500    VAL G  36   CB    VAL G  36   CG2    -0.129                       
REMARK 500    ARG G 131   N     ARG G 131   CA     -0.158                       
REMARK 500    ARG G 131   CB    ARG G 131   CG      0.192                       
REMARK 500    ARG G 131   CG    ARG G 131   CD      0.279                       
REMARK 500    ARG G 131   C     ARG G 131   O      -0.115                       
REMARK 500    PRO G 130   C     ARG G 131   N      -0.178                       
REMARK 500    ARG G 131   C     ARG G 132   N       0.257                       
REMARK 500    TYR G 156   CB    TYR G 156   CG     -0.094                       
REMARK 500    VAL G 157   CA    VAL G 157   CB     -0.140                       
REMARK 500    ARG G 170   CA    ARG G 170   CB      0.165                       
REMARK 500    ARG G 170   CA    ARG G 170   C      -0.162                       
REMARK 500    ARG H 109   CA    ARG H 109   CB     -0.199                       
REMARK 500    LYS H 111   CA    LYS H 111   C      -0.184                       
REMARK 500    LEU H 194   C     LEU H 194   O      -0.231                       
REMARK 500    LEU H 194   C     LEU H 194   OXT    -0.228                       
REMARK 500    ILE I   3   CA    ILE I   3   CB     -0.167                       
REMARK 500    TRP I   8   CD2   TRP I   8   CE3    -0.097                       
REMARK 500    ILE I  43   CA    ILE I  43   C      -0.275                       
REMARK 500    GLY I 207   C     GLY I 207   O      -0.231                       
REMARK 500    TYR J  35   CD1   TYR J  35   CE1    -0.142                       
REMARK 500    TYR J  35   CE1   TYR J  35   CZ     -0.091                       
REMARK 500    TYR J  35   CE2   TYR J  35   CD2    -0.115                       
REMARK 500    GLY J  85   C     VAL J  86   N      -0.383                       
REMARK 500    LYS J  91   C     LYS J  91   O      -0.139                       
REMARK 500    LYS J 101   N     LYS J 101   CA      0.126                       
REMARK 500    ILE J 144   CA    ILE J 144   CB     -0.144                       
REMARK 500    SER J 146   C     PHE J 147   N       0.273                       
REMARK 500    PRO J 164   N     PRO J 164   CA     -0.126                       
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS    1694 BOND DEVIATIONS.                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ARG A  53   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.6 DEGREES          
REMARK 500    PRO A 133   CA  -  N   -  CD  ANGL. DEV. = -11.8 DEGREES          
REMARK 500    GLY A 187   C   -  N   -  CA  ANGL. DEV. =  13.1 DEGREES          
REMARK 500    PRO A 194   C   -  N   -  CA  ANGL. DEV. =  21.1 DEGREES          
REMARK 500    PRO A 194   C   -  N   -  CD  ANGL. DEV. = -20.9 DEGREES          
REMARK 500    ASP A 200   CB  -  CA  -  C   ANGL. DEV. = -19.4 DEGREES          
REMARK 500    PRO A 207   C   -  N   -  CD  ANGL. DEV. = -14.7 DEGREES          
REMARK 500    PRO B  24   C   -  N   -  CD  ANGL. DEV. = -16.8 DEGREES          
REMARK 500    MET B  38   C   -  N   -  CA  ANGL. DEV. = -19.2 DEGREES          
REMARK 500    ILE B  41   CB  -  CA  -  C   ANGL. DEV. =  23.5 DEGREES          
REMARK 500    ILE B  41   CG1 -  CB  -  CG2 ANGL. DEV. = -14.8 DEGREES          
REMARK 500    ILE B  41   C   -  N   -  CA  ANGL. DEV. = -23.0 DEGREES          
REMARK 500    ASN B  76   N   -  CA  -  C   ANGL. DEV. =  17.1 DEGREES          
REMARK 500    ASP B  77   CB  -  CG  -  OD1 ANGL. DEV. =   6.2 DEGREES          
REMARK 500    ASP B  77   N   -  CA  -  C   ANGL. DEV. =  17.4 DEGREES          
REMARK 500    TYR B 133   N   -  CA  -  CB  ANGL. DEV. = -12.3 DEGREES          
REMARK 500    ASN B 148   C   -  N   -  CA  ANGL. DEV. = -17.8 DEGREES          
REMARK 500    LYS B 152   C   -  N   -  CA  ANGL. DEV. = -15.2 DEGREES          
REMARK 500    TYR B 155   CB  -  CA  -  C   ANGL. DEV. = -13.4 DEGREES          
REMARK 500    PRO B 206   C   -  N   -  CD  ANGL. DEV. = -15.1 DEGREES          
REMARK 500    GLY B 233   CA  -  C   -  O   ANGL. DEV. = -11.4 DEGREES          
REMARK 500    GLY C  84   C   -  N   -  CA  ANGL. DEV. = -13.5 DEGREES          
REMARK 500    LYS C  93   O   -  C   -  N   ANGL. DEV. = -13.1 DEGREES          
REMARK 500    ILE C  94   C   -  N   -  CA  ANGL. DEV. =  24.2 DEGREES          
REMARK 500    GLY C 104   N   -  CA  -  C   ANGL. DEV. =  21.9 DEGREES          
REMARK 500    GLN C 105   N   -  CA  -  C   ANGL. DEV. =  18.4 DEGREES          
REMARK 500    PRO C 149   C   -  N   -  CD  ANGL. DEV. = -24.7 DEGREES          
REMARK 500    ASN C 157   N   -  CA  -  C   ANGL. DEV. =  17.4 DEGREES          
REMARK 500    LEU C 218   C   -  N   -  CA  ANGL. DEV. =  16.4 DEGREES          
REMARK 500    LYS C 242   N   -  CA  -  C   ANGL. DEV. =  18.6 DEGREES          
REMARK 500    LEU C 258   CA  -  CB  -  CG  ANGL. DEV. =  14.3 DEGREES          
REMARK 500    LEU C 258   CB  -  CG  -  CD2 ANGL. DEV. =  11.9 DEGREES          
REMARK 500    HIS C 262   CB  -  CA  -  C   ANGL. DEV. = -12.1 DEGREES          
REMARK 500    GLN D   4   N   -  CA  -  CB  ANGL. DEV. = -21.2 DEGREES          
REMARK 500    GLN D   4   CG  -  CD  -  OE1 ANGL. DEV. = -24.4 DEGREES          
REMARK 500    GLN D   4   CG  -  CD  -  NE2 ANGL. DEV. =  24.0 DEGREES          
REMARK 500    GLN D   4   CA  -  C   -  O   ANGL. DEV. =  12.8 DEGREES          
REMARK 500    PRO D  43   C   -  N   -  CD  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    THR D  53   C   -  N   -  CA  ANGL. DEV. = -17.9 DEGREES          
REMARK 500    SER D  83   N   -  CA  -  CB  ANGL. DEV. =  10.4 DEGREES          
REMARK 500    GLY D  82   O   -  C   -  N   ANGL. DEV. = -11.7 DEGREES          
REMARK 500    SER D  83   C   -  N   -  CA  ANGL. DEV. = -23.4 DEGREES          
REMARK 500    ARG D  94   CB  -  CA  -  C   ANGL. DEV. = -15.1 DEGREES          
REMARK 500    ASP D 193   N   -  CA  -  C   ANGL. DEV. = -25.7 DEGREES          
REMARK 500    PRO D 194   C   -  N   -  CA  ANGL. DEV. = -19.6 DEGREES          
REMARK 500    PRO D 194   C   -  N   -  CD  ANGL. DEV. =  17.6 DEGREES          
REMARK 500    PRO D 205   C   -  N   -  CD  ANGL. DEV. = -13.0 DEGREES          
REMARK 500    PRO E  31   C   -  N   -  CA  ANGL. DEV. =   9.6 DEGREES          
REMARK 500    PRO E  43   CA  -  N   -  CD  ANGL. DEV. = -11.9 DEGREES          
REMARK 500    PRO E  43   C   -  N   -  CD  ANGL. DEV. = -14.8 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS    2367 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP A   6      -89.09   -134.12                                   
REMARK 500    VAL A   7      -41.18    -24.21                                   
REMARK 500    GLN A   9     -158.41    -58.47                                   
REMARK 500    LYS A  11      112.43     61.89                                   
REMARK 500    THR A  23      -78.74    -64.82                                   
REMARK 500    LEU A  25      132.92    -38.87                                   
REMARK 500    LEU A  30      -83.41    -63.73                                   
REMARK 500    ASP A  31      153.49    109.34                                   
REMARK 500    ALA A  67      -20.65     92.17                                   
REMARK 500    ALA A  96      100.11     51.25                                   
REMARK 500    PHE A 103      -46.30     -7.79                                   
REMARK 500    THR A 104      108.69     82.67                                   
REMARK 500    ASN A 110       78.79     80.07                                   
REMARK 500    ILE A 112      -36.14    -30.38                                   
REMARK 500    GLU A 118       62.67   -112.79                                   
REMARK 500    VAL A 140       34.08   -162.17                                   
REMARK 500    PRO A 143      155.96    -49.72                                   
REMARK 500    ASP A 151       55.58   -114.29                                   
REMARK 500    ILE A 159      116.44    100.85                                   
REMARK 500    CYS A 163      -93.95   -134.53                                   
REMARK 500    ASN A 164      -37.14    170.81                                   
REMARK 500    ASN A 165       -0.58     25.36                                   
REMARK 500    ALA A 168     -131.34     49.98                                   
REMARK 500    MET A 185      162.74    -49.04                                   
REMARK 500    ARG A 186       79.28      5.60                                   
REMARK 500    THR A 188       75.42    163.18                                   
REMARK 500    SER A 190      128.71     62.34                                   
REMARK 500    ARG A 191       50.18     87.51                                   
REMARK 500    GLU A 192       46.06    -30.66                                   
REMARK 500    PRO A 194     -160.70    -60.40                                   
REMARK 500    PHE A 203      143.88    127.13                                   
REMARK 500    ARG A 205     -109.90    -80.48                                   
REMARK 500    ASP A 206      165.87     83.30                                   
REMARK 500    PRO A 207     -135.93    -54.61                                   
REMARK 500    VAL B  21      131.06   -174.02                                   
REMARK 500    LYS B  27      -18.31    166.98                                   
REMARK 500    ASN B  40      -95.14   -105.57                                   
REMARK 500    THR B  55       33.28    -89.14                                   
REMARK 500    LYS B  56      153.47    162.75                                   
REMARK 500    ASP B  77     -132.51    143.47                                   
REMARK 500    GLU B  78       -9.62      5.99                                   
REMARK 500    ARG B  82      133.51     96.09                                   
REMARK 500    ASP B 104     -169.49   -121.49                                   
REMARK 500    THR B 106     -153.93     98.01                                   
REMARK 500    ARG B 107      -54.66   -123.26                                   
REMARK 500    TRP B 117        3.01     81.23                                   
REMARK 500    ASN B 148       26.61    -75.35                                   
REMARK 500    THR B 153      -78.63    -75.58                                   
REMARK 500    SER B 154       44.59     95.52                                   
REMARK 500    ASN B 179      135.81    108.19                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     705 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ALA A    4     LEU A    5                 -100.59                    
REMARK 500 GLU A  192     HIS A  193                  132.13                    
REMARK 500 ASP A  206     PRO A  207                 -117.00                    
REMARK 500 GLN B   75     ASN B   76                 -124.47                    
REMARK 500 ASN B   76     ASP B   77                  133.55                    
REMARK 500 CYS B  146     ASN B  147                 -135.91                    
REMARK 500 VAL C   97     GLN C   98                  144.64                    
REMARK 500 ASN C  157     LYS C  158                 -148.84                    
REMARK 500 VAL D    3     GLN D    4                 -145.73                    
REMARK 500 GLY D  144     GLN D  145                 -137.40                    
REMARK 500 MET E    1     ALA E    2                 -110.99                    
REMARK 500 ILE E  129     PHE E  130                 -147.23                    
REMARK 500 GLU F   43     LYS F   44                  137.12                    
REMARK 500 LYS F   44     TYR F   45                 -144.40                    
REMARK 500 HIS F   79     GLY F   80                 -149.74                    
REMARK 500 PRO H   16     ASP H   17                   57.83                    
REMARK 500 ASP H   17     GLU H   18                 -113.06                    
REMARK 500 VAL H   53     GLY H   54                 -149.80                    
REMARK 500 THR H  105     ARG H  106                   95.47                    
REMARK 500 SER H  108     ARG H  109                  -93.25                    
REMARK 500 PRO H  190     GLU H  191                 -118.79                    
REMARK 500 GLN H  193     LEU H  194                   92.88                    
REMARK 500 ILE I    3     SER I    4                 -133.38                    
REMARK 500 ASN I  155     ALA I  156                 -133.09                    
REMARK 500 PRO J   16     ARG J   17                 -149.43                    
REMARK 500 GLY J   90     LYS J   91                  149.11                    
REMARK 500 MET J   92     LYS J   93                  140.52                    
REMARK 500 LEU J  161     ARG J  162                  147.43                    
REMARK 500 ARG J  162     SER J  163                  139.83                    
REMARK 500 TYR J  165     GLY J  166                 -130.91                    
REMARK 500 MET K   29     PRO K   30                 -148.66                    
REMARK 500 PRO K   30     LYS K   31                  129.45                    
REMARK 500 ASP K   37     LYS K   38                  134.37                    
REMARK 500 LEU K   43     HIS K   44                 -114.29                    
REMARK 500 PRO K   86     PRO K   87                 -143.29                    
REMARK 500 ALA K   92     THR K   93                  137.26                    
REMARK 500 SER K   97     ARG K   98                  145.13                    
REMARK 500 GLN L   18     ASN L   19                  126.43                    
REMARK 500 GLY L   26     GLU L   27                   40.64                    
REMARK 500 GLU L   27     THR L   28                  -50.07                    
REMARK 500 ARG L   97     LYS L   98                 -141.03                    
REMARK 500 LYS L  147     ALA L  148                 -116.14                    
REMARK 500 GLY M   98     LYS M   99                  142.71                    
REMARK 500 GLN N   13     SER N   14                  145.81                    
REMARK 500 SER N   14     ALA N   15                  143.67                    
REMARK 500 TYR N   18     ARG N   19                 -133.83                    
REMARK 500 PRO N   82     ASP N   83                 -144.01                    
REMARK 500 ASP O  138     SER O  139                  146.71                    
REMARK 500 TYR P   17     ARG P   18                 -134.96                    
REMARK 500 ASP P   27     MET P   28                  140.88                    
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     108 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    ARG A  63         0.24    SIDE CHAIN                              
REMARK 500    ARG H 109         0.12    SIDE CHAIN                              
REMARK 500    ARG H 118         0.12    SIDE CHAIN                              
REMARK 500    TYR I  55         0.24    SIDE CHAIN                              
REMARK 500    ARG K  55         0.23    SIDE CHAIN                              
REMARK 500    TYR K  70         0.08    SIDE CHAIN                              
REMARK 500    TYR P  17         0.28    SIDE CHAIN                              
REMARK 500    ARG P  18         0.17    SIDE CHAIN                              
REMARK 500    ARG Q 146         0.08    SIDE CHAIN                              
REMARK 500    TYR S  40         0.11    SIDE CHAIN                              
REMARK 500    HIS T  42         0.15    SIDE CHAIN                              
REMARK 500    ARG T  82         0.20    SIDE CHAIN                              
REMARK 500    ARG V  61         0.12    SIDE CHAIN                              
REMARK 500    ARG Z 104         0.28    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    THR A  23        -10.23                                           
REMARK 500    THR A  97        -12.83                                           
REMARK 500    ALA A 146        -12.13                                           
REMARK 500    MET A 185        -10.66                                           
REMARK 500    GLU A 192        -20.72                                           
REMARK 500    PRO A 199        -10.23                                           
REMARK 500    ASP A 206         15.35                                           
REMARK 500    LYS B  56        -11.85                                           
REMARK 500    VAL C  97        -15.44                                           
REMARK 500    GLY C 160         13.52                                           
REMARK 500    TRP C 241        -13.15                                           
REMARK 500    VAL D   3         19.77                                           
REMARK 500    LEU D  96        -10.03                                           
REMARK 500    LEU D 190         10.65                                           
REMARK 500    GLN G 155        -13.40                                           
REMARK 500    LYS H 113        -10.42                                           
REMARK 500    GLY I   2        -11.34                                           
REMARK 500    ARG I 123        -10.10                                           
REMARK 500    LEU I 129        -16.55                                           
REMARK 500    PRO I 131         10.34                                           
REMARK 500    LEU I 190        -11.62                                           
REMARK 500    GLY J  85         13.98                                           
REMARK 500    LYS J  91         11.17                                           
REMARK 500    SER J 146        -21.84                                           
REMARK 500    LEU J 161        -19.60                                           
REMARK 500    PRO J 164         11.23                                           
REMARK 500    ILE K  89         11.14                                           
REMARK 500    VAL K  90        -11.21                                           
REMARK 500    ALA L 149        -11.46                                           
REMARK 500    LYS L 152        -20.42                                           
REMARK 500    GLY P  48        -14.74                                           
REMARK 500    MET R   1        -10.47                                           
REMARK 500    VAL R  88         26.17                                           
REMARK 500    TYR S  40        -12.91                                           
REMARK 500    GLN S  87        -12.51                                           
REMARK 500    ARG S 141         26.90                                           
REMARK 500    VAL T   4        -10.59                                           
REMARK 500    LYS T 142         12.66                                           
REMARK 500    CYS U  70        -16.31                                           
REMARK 500    SER U  93        -13.23                                           
REMARK 500    ILE U 104         19.18                                           
REMARK 500    SER U 105        -11.52                                           
REMARK 500    GLY V  48         13.11                                           
REMARK 500    GLY V  63        -12.24                                           
REMARK 500    GLN V  81         19.76                                           
REMARK 500    VAL W   2        -22.42                                           
REMARK 500    HIS X  23        -16.77                                           
REMARK 500    GLU Y  86         16.61                                           
REMARK 500    SER Z 101        -12.48                                           
REMARK 500    ARG Z 104        -14.05                                           
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      61 MAIN CHAIN PLANARITY DEVIATIONS.              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR                        
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE                                    
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500      C i   4       -20.8      D          D   OUTSIDE RANGE           
REMARK 500      A i  25       -49.2      D          D   OUTSIDE RANGE           
REMARK 500      A i  38       -46.3      D          D   OUTSIDE RANGE           
REMARK 500      C i  53       -46.4      D          D   OUTSIDE RANGE           
REMARK 500      G i  66       -20.9      D          D   OUTSIDE RANGE           
REMARK 500      C i  72       -20.3      D          D   OUTSIDE RANGE           
REMARK 500      C i  78       -45.7      D          D   OUTSIDE RANGE           
REMARK 500      A i  79       -47.8      D          D   OUTSIDE RANGE           
REMARK 500      A i  92       -23.0      D          D   OUTSIDE RANGE           
REMARK 500      U i  93       -45.9      D          D   OUTSIDE RANGE           
REMARK 500      A i 141       -46.1      D          D   OUTSIDE RANGE           
REMARK 500      C i 142       -24.2      D          D   OUTSIDE RANGE           
REMARK 500      U i 143       -24.5      D          D   OUTSIDE RANGE           
REMARK 500      G i 145       -19.4      D          D   OUTSIDE RANGE           
REMARK 500      A i 147       -49.5      D          D   OUTSIDE RANGE           
REMARK 500      C i 179       -24.5      D          D   OUTSIDE RANGE           
REMARK 500      G i 204       -49.8      D          D   OUTSIDE RANGE           
REMARK 500      G i 205       -22.3      D          D   OUTSIDE RANGE           
REMARK 500      U i 215       -19.6      D          D   OUTSIDE RANGE           
REMARK 500      G i 222       -24.5      D          D   OUTSIDE RANGE           
REMARK 500      U i 224       -45.9      D          D   OUTSIDE RANGE           
REMARK 500      C i 234       -45.9      D          D   OUTSIDE RANGE           
REMARK 500      G i 274       -21.8      D          D   OUTSIDE RANGE           
REMARK 500      G i 279       -45.4      D          D   OUTSIDE RANGE           
REMARK 500      G i 282       -24.3      D          D   OUTSIDE RANGE           
REMARK 500      U i 287       -17.1      D          D   OUTSIDE RANGE           
REMARK 500      G i 299       -11.1      D          D   OUTSIDE RANGE           
REMARK 500      U i 314       -24.4      D          D   OUTSIDE RANGE           
REMARK 500      C i 343       -22.4      D          D   OUTSIDE RANGE           
REMARK 500      C i 346       -21.1      D          D   OUTSIDE RANGE           
REMARK 500      C i 359       -21.8      D          D   OUTSIDE RANGE           
REMARK 500      U i 368       -22.2      D          D   OUTSIDE RANGE           
REMARK 500      C i 376       -23.4      D          D   OUTSIDE RANGE           
REMARK 500      G i 385       -23.3      D          D   OUTSIDE RANGE           
REMARK 500      A i 405       -45.1      D          D   OUTSIDE RANGE           
REMARK 500      A i 408       -22.9      D          D   OUTSIDE RANGE           
REMARK 500      G i 410       -23.4      D          D   OUTSIDE RANGE           
REMARK 500      A i 435       -23.6      D          D   OUTSIDE RANGE           
REMARK 500      A i 437       -46.2      D          D   OUTSIDE RANGE           
REMARK 500      G i 456       -21.7      D          D   OUTSIDE RANGE           
REMARK 500      G i 464       -24.7      D          D   OUTSIDE RANGE           
REMARK 500      A i 509       -46.1      D          D   OUTSIDE RANGE           
REMARK 500      A i 518       -24.1      D          D   OUTSIDE RANGE           
REMARK 500      U i 541       -19.6      D          D   OUTSIDE RANGE           
REMARK 500      G i 542       -24.3      D          D   OUTSIDE RANGE           
REMARK 500      A i 544       -11.2      D          D   OUTSIDE RANGE           
REMARK 500      G i 548       -22.4      D          D   OUTSIDE RANGE           
REMARK 500      U i 581       -16.5      D          D   OUTSIDE RANGE           
REMARK 500      G i 596       -22.7      D          D   OUTSIDE RANGE           
REMARK 500      C i 612       -25.0      D          D   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     288 CHIRALITY DEVIATIONS.                         
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 The reference for chain A is XP_002712810.1 at NCBI which indicates  
REMARK 999 Met at position 1 instead of Ala                                     
DBREF  4KZX B    1   264  UNP    G1TN72   G1TN72_RABIT     1    264             
DBREF  4KZX C    1   278  UNP    G1U2Z9   G1U2Z9_RABIT     1    278             
DBREF  4KZX D    1   243  UNP    G1TNM3   G1TNM3_RABIT     1    243             
DBREF  4KZX E    1   263  UNP    G1TK17   G1TK17_RABIT     1    263             
DBREF  4KZX F    1   204  UNP    G1TFM5   G1TFM5_RABIT     1    204             
DBREF  4KZX G    1   249  UNP    G1TM55   G1TM55_RABIT     1    249             
DBREF  4KZX H    1   194  UNP    G1SVB0   G1SVB0_RABIT     1    194             
DBREF  4KZX I    1   208  UNP    G1TJW1   G1TJW1_RABIT     1    208             
DBREF  4KZX J    1   194  UNP    B7NZS8   B7NZS8_RABIT     1    194             
DBREF  4KZX K    1   165  UNP    G1T168   G1T168_RABIT     1    165             
DBREF  4KZX L    1   158  UNP    G1TRM4   G1TRM4_RABIT     1    158             
DBREF  4KZX M    1   132  UNP    G1SFR8   G1SFR8_RABIT     1    132             
DBREF  4KZX N    1   151  UNP    G1SP51   G1SP51_RABIT     1    151             
DBREF  4KZX O    1   151  UNP    G1U472   G1U472_RABIT     1    151             
DBREF  4KZX P    1   145  UNP    G1U0Q2   G1U0Q2_RABIT     1    145             
DBREF  4KZX Q    1   146  UNP    G1SGX4   G1SGX4_RABIT    27    172             
DBREF  4KZX R    1   135  UNP    G1TU13   G1TU13_RABIT     1    135             
DBREF  4KZX S    1   152  UNP    G1TPG3   G1TPG3_RABIT     1    152             
DBREF  4KZX T    1   145  UNP    G1TN62   G1TN62_RABIT     1    145             
DBREF  4KZX U    1   119  UNP    G1SIZ2   G1SIZ2_RABIT     1    119             
DBREF  4KZX V    1    83  UNP    G1TM82   G1TM82_RABIT     1     83             
DBREF  4KZX W    1   130  UNP    G1TG89   G1TG89_RABIT     1    130             
DBREF  4KZX X    1   143  UNP    G1SZ47   G1SZ47_RABIT     1    143             
DBREF  4KZX Y    1   133  UNP    G1TS40   G1TS40_RABIT     1    133             
DBREF  4KZX Z    1   125  UNP    G1TDB3   G1TDB3_RABIT     1    125             
DBREF  4KZX a    1   115  UNP    G1TFE8   G1TFE8_RABIT     1    115             
DBREF  4KZX b    1    84  UNP    G1TZ76   G1TZ76_RABIT     1     84             
DBREF  4KZX c    1    69  UNP    G1TIB4   G1TIB4_RABIT     1     69             
DBREF  4KZX d    1    56  UNP    G1U7M4   G1U7M4_RABIT     1     56             
DBREF  4KZX e    1   133  UNP    G1T8A2   G1T8A2_RABIT     1    133             
DBREF  4KZX f    1   156  UNP    G1SK22   G1SK22_RABIT     1    156             
DBREF  4KZX g    1   317  UNP    G1SJB4   G1SJB4_RABIT     1    317             
DBREF1 4KZX i    1  1863  GB                   NR_033238                        
DBREF2 4KZX i     283837872                           1        1863             
DBREF  4KZX l    1   113  UNP    P41567   EIF1_HUMAN       1    113             
DBREF  4KZX A    1   295  PDB    4KZX     4KZX             1    295             
SEQADV 4KZX MET X    1  UNP  G1SZ47    ALA     1 SEE REMARK 999                 
SEQRES   1 A  295  MET SER GLY ALA LEU ASP VAL LEU GLN MET LYS GLU GLU          
SEQRES   2 A  295  ASP VAL LEU LYS PHE LEU ALA ALA GLY THR HIS LEU GLY          
SEQRES   3 A  295  GLY THR ASN LEU ASP PHE GLN MET GLU GLN TYR ILE TYR          
SEQRES   4 A  295  LYS ARG LYS SER ASP GLY ILE TYR ILE ILE ASN LEU LYS          
SEQRES   5 A  295  ARG THR TRP GLU LYS LEU LEU LEU ALA ALA ARG ALA ILE          
SEQRES   6 A  295  VAL ALA ILE GLU ASN PRO ALA ASP VAL SER VAL ILE SER          
SEQRES   7 A  295  SER ARG ASN THR GLY GLN ARG ALA VAL LEU LYS PHE ALA          
SEQRES   8 A  295  ALA ALA THR GLY ALA THR PRO ILE ALA GLY ARG PHE THR          
SEQRES   9 A  295  PRO GLY THR PHE THR ASN GLN ILE GLN ALA ALA PHE ARG          
SEQRES  10 A  295  GLU PRO ARG LEU LEU VAL VAL THR ASP PRO ARG ALA ASP          
SEQRES  11 A  295  HIS GLN PRO LEU THR GLU ALA SER TYR VAL ASN LEU PRO          
SEQRES  12 A  295  THR ILE ALA LEU CYS ASN THR ASP SER PRO LEU ARG TYR          
SEQRES  13 A  295  VAL ASP ILE ALA ILE PRO CYS ASN ASN LYS GLY ALA HIS          
SEQRES  14 A  295  SER VAL GLY LEU MET TRP TRP MET LEU ALA ARG GLU VAL          
SEQRES  15 A  295  LEU ARG MET ARG GLY THR ILE SER ARG GLU HIS PRO TRP          
SEQRES  16 A  295  GLU VAL MET PRO ASP LEU TYR PHE TYR ARG ASP PRO GLU          
SEQRES  17 A  295  GLU ILE GLU LYS GLU GLU GLN ALA ALA ALA GLU LYS ALA          
SEQRES  18 A  295  VAL THR LYS GLU GLU PHE GLN GLY GLU TRP THR ALA PRO          
SEQRES  19 A  295  ALA PRO GLU PHE THR ALA THR GLN PRO GLU VAL ALA ASP          
SEQRES  20 A  295  TRP SER GLU GLY VAL GLN VAL PRO SER VAL PRO ILE GLN          
SEQRES  21 A  295  GLN PHE PRO THR GLU ASP TRP SER ALA GLN PRO ALA THR          
SEQRES  22 A  295  GLU ASP TRP SER ALA ALA PRO THR ALA GLN ALA THR GLU          
SEQRES  23 A  295  TRP VAL GLY THR THR THR GLU TRP SER                          
SEQRES   1 B  264  MET ALA VAL GLY LYS ASN LYS ARG LEU THR LYS GLY GLY          
SEQRES   2 B  264  LYS LYS GLY ALA LYS LYS LYS VAL VAL ASP PRO PHE SER          
SEQRES   3 B  264  LYS LYS ASP TRP TYR ASP VAL LYS ALA PRO ALA MET PHE          
SEQRES   4 B  264  ASN ILE ARG ASN ILE GLY LYS THR LEU VAL THR ARG THR          
SEQRES   5 B  264  GLN GLY THR LYS ILE ALA SER ASP GLY LEU LYS GLY ARG          
SEQRES   6 B  264  VAL PHE GLU VAL SER LEU ALA ASP LEU GLN ASN ASP GLU          
SEQRES   7 B  264  VAL ALA PHE ARG LYS PHE LYS LEU ILE THR GLU ASP VAL          
SEQRES   8 B  264  GLN GLY LYS ASN CYS LEU THR ASN PHE HIS GLY MET ASP          
SEQRES   9 B  264  LEU THR ARG ASP LYS MET CYS SER MET VAL LYS LYS TRP          
SEQRES  10 B  264  GLN THR MET ILE GLU ALA HIS VAL ASP VAL LYS THR THR          
SEQRES  11 B  264  ASP GLY TYR LEU LEU HIS LEU PHE CYS VAL GLY PHE THR          
SEQRES  12 B  264  LYS LYS CYS ASN ASN GLN ILE ARG LYS THR SER TYR ALA          
SEQRES  13 B  264  GLN HIS GLN GLN VAL ARG GLN ILE ARG LYS LYS MET MET          
SEQRES  14 B  264  GLU ILE MET THR ARG GLU VAL GLN THR ASN ASP LEU LYS          
SEQRES  15 B  264  GLU VAL VAL ASN LYS LEU ILE PRO ASP SER ILE GLY LYS          
SEQRES  16 B  264  ASP ILE GLU LYS ALA CYS GLN SER ILE TYR PRO LEU HIS          
SEQRES  17 B  264  ASP VAL PHE VAL ARG LYS VAL LYS MET LEU LYS LYS PRO          
SEQRES  18 B  264  LYS PHE GLU LEU GLY LYS LEU MET GLU LEU HIS GLY GLU          
SEQRES  19 B  264  GLY SER SER SER GLY LYS ALA THR GLY ASP GLU THR GLY          
SEQRES  20 B  264  ALA LYS VAL GLU ARG ALA ASP GLY TYR GLU PRO PRO VAL          
SEQRES  21 B  264  GLN GLU SER VAL                                              
SEQRES   1 C  278  MET VAL ASP ASP ALA GLY ALA ALA GLY GLY PRO GLY GLY          
SEQRES   2 C  278  PRO GLY GLY PRO GLY MET GLY GLY ARG GLY GLY PHE ARG          
SEQRES   3 C  278  GLY GLY PHE GLY SER GLY ILE ARG GLY CYS GLY GLY LYS          
SEQRES   4 C  278  ALA GLY ASP LYS GLU TRP LEU PRO VAL THR LYS LEU GLY          
SEQRES   5 C  278  ARG LEU VAL LYS ASP MET LYS ILE LYS SER LEU GLU GLU          
SEQRES   6 C  278  ILE TYR LEU PHE SER LEU PRO ILE LYS GLU SER GLU ILE          
SEQRES   7 C  278  ILE ASP PHE PHE LEU GLY ALA ALA LEU LYS ASP LYS VAL          
SEQRES   8 C  278  LEU LYS ILE MET PRO VAL GLN LYS GLN THR GLN ALA GLY          
SEQRES   9 C  278  GLN ARG THR ARG PHE LYS ALA PHE VAL ALA ILE GLY ASP          
SEQRES  10 C  278  TYR ASN GLY HIS VAL GLY LEU GLY MET LYS CYS SER LYS          
SEQRES  11 C  278  GLU VAL ALA THR ALA ILE ARG GLY ALA ILE ILE LEU ALA          
SEQRES  12 C  278  LYS LEU SER ILE VAL PRO VAL ARG ARG GLY TYR TRP GLY          
SEQRES  13 C  278  ASN LYS ILE GLY LYS PRO HIS THR VAL ARG CYS LYS VAL          
SEQRES  14 C  278  THR GLY ARG CYS GLY SER VAL LEU VAL ARG LEU ILE PRO          
SEQRES  15 C  278  ALA PRO ARG GLY THR GLY ILE ILE SER ALA PRO VAL PRO          
SEQRES  16 C  278  LYS LYS LEU LEU LEU MET ALA GLY ILE ASP ASP CYS TYR          
SEQRES  17 C  278  THR SER ALA GLY GLY CYS THR ALA THR LEU GLY ASN PHE          
SEQRES  18 C  278  ALA LYS ALA THR PHE ASP ALA ILE SER LYS THR TYR SER          
SEQRES  19 C  278  TYR LEU THR PRO ASP LEU TRP LYS GLU THR VAL PHE THR          
SEQRES  20 C  278  LYS SER PRO TYR GLN GLU PHE THR ASP HIS LEU VAL LYS          
SEQRES  21 C  278  THR HIS THR ARG VAL SER VAL GLN ARG THR GLN ALA PRO          
SEQRES  22 C  278  ALA VAL ALA THR THR                                          
SEQRES   1 D  243  MET ALA VAL GLN ILE SER LYS LYS ARG LYS PHE VAL ALA          
SEQRES   2 D  243  ASP GLY ILE PHE LYS ALA GLU LEU ASN GLU PHE LEU THR          
SEQRES   3 D  243  ARG GLU LEU ALA GLU ASP GLY TYR SER GLY VAL GLU VAL          
SEQRES   4 D  243  ARG VAL THR PRO THR ARG THR GLU ILE ILE ILE LEU ALA          
SEQRES   5 D  243  THR ARG THR GLN ASN VAL LEU GLY GLU LYS GLY ARG ARG          
SEQRES   6 D  243  ILE ARG GLU LEU THR ALA VAL VAL GLN LYS ARG PHE GLY          
SEQRES   7 D  243  PHE PRO GLU GLY SER VAL GLU LEU TYR ALA GLU LYS VAL          
SEQRES   8 D  243  ALA THR ARG GLY LEU CYS ALA ILE ALA GLN ALA GLU SER          
SEQRES   9 D  243  LEU ARG TYR LYS LEU LEU GLY GLY LEU ALA VAL ARG ARG          
SEQRES  10 D  243  ALA CYS TYR GLY VAL LEU ARG PHE ILE MET GLU SER GLY          
SEQRES  11 D  243  ALA LYS GLY CYS GLU VAL VAL VAL SER GLY LYS LEU ARG          
SEQRES  12 D  243  GLY GLN ARG ALA LYS SER MET LYS PHE VAL ASP GLY LEU          
SEQRES  13 D  243  MET ILE HIS SER GLY ASP PRO VAL ASN TYR TYR VAL ASP          
SEQRES  14 D  243  THR ALA VAL ARG HIS VAL LEU LEU ARG GLN GLY VAL LEU          
SEQRES  15 D  243  GLY ILE LYS VAL LYS ILE MET LEU PRO TRP ASP PRO SER          
SEQRES  16 D  243  GLY LYS ILE GLY PRO LYS LYS PRO LEU PRO ASP HIS VAL          
SEQRES  17 D  243  SER ILE VAL GLU PRO LYS ASP GLU ILE LEU PRO THR THR          
SEQRES  18 D  243  PRO ILE SER GLU GLN LYS GLY GLY LYS PRO GLU PRO PRO          
SEQRES  19 D  243  ALA MET PRO GLN PRO VAL PRO THR ALA                          
SEQRES   1 E  263  MET ALA ARG GLY PRO LYS LYS HIS LEU LYS ARG VAL ALA          
SEQRES   2 E  263  ALA PRO LYS HIS TRP MET LEU ASP LYS LEU THR SER VAL          
SEQRES   3 E  263  PHE ALA PRO ARG PRO SER THR GLY PRO HIS LYS LEU ARG          
SEQRES   4 E  263  GLU CYS LEU PRO LEU ILE ILE PHE LEU ARG ASN LYS LEU          
SEQRES   5 E  263  LYS TYR ALA LEU THR GLY ASP GLU VAL LYS LYS ILE CYS          
SEQRES   6 E  263  MET GLN ARG PHE ILE LYS ILE ASP GLY LYS VAL ARG ALA          
SEQRES   7 E  263  ASP ILE THR TYR PRO ALA GLY PHE MET ASP VAL ILE SER          
SEQRES   8 E  263  ILE ASP LYS THR GLY GLU ASN PHE ARG LEU ILE TYR ASP          
SEQRES   9 E  263  THR LYS GLY ARG PHE ALA VAL HIS ARG ILE THR PRO GLU          
SEQRES  10 E  263  GLU ALA LYS TYR LYS LEU CYS LYS VAL ARG LYS ILE PHE          
SEQRES  11 E  263  VAL GLY THR LYS GLY ILE PRO HIS LEU VAL THR HIS ASP          
SEQRES  12 E  263  ALA ARG THR ILE ARG TYR PRO ASP PRO LEU ILE LYS MET          
SEQRES  13 E  263  ASN ASP THR ILE GLN ILE ASP LEU GLU THR GLY LYS ILE          
SEQRES  14 E  263  THR ASP PHE ILE LYS PHE ASP THR GLY ASN LEU CYS MET          
SEQRES  15 E  263  VAL THR GLY GLY ALA ASN LEU GLY ARG ILE GLY VAL ILE          
SEQRES  16 E  263  THR ASN ARG GLU ARG HIS PRO GLY SER PHE ASP VAL VAL          
SEQRES  17 E  263  HIS VAL LYS ASP ALA ASN GLY ASN SER PHE ALA THR ARG          
SEQRES  18 E  263  LEU SER ASN ILE PHE VAL ILE GLY LYS GLY ASN LYS PRO          
SEQRES  19 E  263  TRP ILE SER LEU PRO ARG GLY LYS GLY ILE ARG LEU THR          
SEQRES  20 E  263  ILE ALA GLU GLU ARG ASP LYS ARG LEU ALA ALA LYS GLN          
SEQRES  21 E  263  SER SER GLY                                                  
SEQRES   1 F  204  MET THR GLU TRP GLU THR ALA ALA PRO ALA VAL ALA GLU          
SEQRES   2 F  204  THR PRO ASP ILE LYS LEU PHE GLY LYS TRP SER THR ASP          
SEQRES   3 F  204  ASP VAL GLN ILE ASN ASP ILE SER LEU GLN ASP TYR ILE          
SEQRES   4 F  204  ALA VAL LYS GLU LYS TYR ALA LYS TYR LEU PRO HIS SER          
SEQRES   5 F  204  ALA GLY ARG TYR ALA ALA LYS ARG PHE ARG LYS ALA GLN          
SEQRES   6 F  204  CYS PRO ILE VAL GLU ARG LEU THR ASN SER MET MET MET          
SEQRES   7 F  204  HIS GLY ARG ASN ASN GLY LYS LYS LEU MET THR VAL ARG          
SEQRES   8 F  204  ILE VAL LYS HIS ALA PHE GLU ILE ILE HIS LEU LEU THR          
SEQRES   9 F  204  GLY GLU ASN PRO LEU GLN VAL LEU VAL ASN ALA ILE ILE          
SEQRES  10 F  204  ASN SER GLY PRO ARG GLU ASP SER THR ARG ILE GLY ARG          
SEQRES  11 F  204  ALA GLY THR VAL ARG ARG GLN ALA VAL ASP VAL SER PRO          
SEQRES  12 F  204  LEU ARG ARG VAL ASN GLN ALA ILE TRP LEU LEU CYS THR          
SEQRES  13 F  204  GLY ALA ARG GLU ALA ALA PHE ARG ASN ILE LYS THR ILE          
SEQRES  14 F  204  ALA GLU CYS LEU ALA ASP GLU LEU ILE ASN ALA ALA LYS          
SEQRES  15 F  204  GLY SER SER ASN SER TYR ALA ILE LYS LYS LYS ASP GLU          
SEQRES  16 F  204  LEU GLU ARG VAL ALA LYS SER ASN ARG                          
SEQRES   1 G  249  MET LYS LEU ASN ILE SER PHE PRO ALA THR GLY CYS GLN          
SEQRES   2 G  249  LYS LEU ILE GLU VAL ASP ASP GLU ARG LYS LEU ARG THR          
SEQRES   3 G  249  PHE TYR GLU LYS ARG MET ALA THR GLU VAL ALA ALA ASP          
SEQRES   4 G  249  ALA LEU GLY GLU GLU TRP LYS GLY TYR VAL VAL ARG ILE          
SEQRES   5 G  249  SER GLY GLY ASN ASP LYS GLN GLY PHE PRO MET LYS GLN          
SEQRES   6 G  249  GLY VAL LEU THR HIS GLY ARG VAL ARG LEU LEU LEU SER          
SEQRES   7 G  249  LYS GLY HIS SER CYS TYR ARG PRO ARG ARG THR GLY GLU          
SEQRES   8 G  249  ARG LYS ARG LYS SER VAL ARG GLY CYS ILE VAL ASP ALA          
SEQRES   9 G  249  ASN LEU SER VAL LEU ASN LEU VAL ILE VAL LYS LYS GLY          
SEQRES  10 G  249  GLU LYS ASP ILE PRO GLY LEU THR ASP THR THR VAL PRO          
SEQRES  11 G  249  ARG ARG LEU GLY PRO LYS ARG ALA SER ARG ILE ARG LYS          
SEQRES  12 G  249  LEU PHE ASN LEU SER LYS GLU ASP ASP VAL ARG GLN TYR          
SEQRES  13 G  249  VAL VAL ARG LYS PRO LEU ASN LYS GLU GLY LYS LYS PRO          
SEQRES  14 G  249  ARG THR LYS ALA PRO LYS ILE GLN ARG LEU VAL THR PRO          
SEQRES  15 G  249  ARG VAL LEU GLN HIS LYS ARG ARG ARG ILE ALA LEU LYS          
SEQRES  16 G  249  LYS GLN ARG THR LYS LYS ASN LYS GLU GLU ALA ALA GLU          
SEQRES  17 G  249  TYR ALA LYS LEU LEU ALA LYS ARG MET LYS GLU ALA LYS          
SEQRES  18 G  249  GLU LYS ARG GLN GLU GLN ILE ALA LYS ARG ARG ARG LEU          
SEQRES  19 G  249  SER SER LEU ARG ALA SER THR SER LYS SER GLU SER SER          
SEQRES  20 G  249  GLN LYS                                                      
SEQRES   1 H  194  MET PHE SER SER SER ALA LYS ILE VAL LYS PRO ASN GLY          
SEQRES   2 H  194  GLU LYS PRO ASP GLU PHE GLU SER GLY ILE SER GLN ALA          
SEQRES   3 H  194  LEU LEU GLU LEU GLU MET ASN SER ASP LEU LYS ALA GLN          
SEQRES   4 H  194  LEU ARG GLU LEU ASN ILE THR ALA ALA LYS GLU ILE GLU          
SEQRES   5 H  194  VAL GLY GLY GLY ARG LYS ALA ILE ILE ILE PHE VAL PRO          
SEQRES   6 H  194  VAL PRO GLN LEU LYS SER PHE GLN LYS ILE GLN VAL ARG          
SEQRES   7 H  194  LEU VAL ARG GLU LEU GLU LYS LYS PHE SER GLY LYS HIS          
SEQRES   8 H  194  VAL VAL PHE ILE ALA GLN ARG ARG ILE LEU PRO LYS PRO          
SEQRES   9 H  194  THR ARG LYS SER ARG THR LYS ASN LYS GLN LYS ARG PRO          
SEQRES  10 H  194  ARG SER ARG THR LEU THR ALA VAL HIS ASP ALA ILE LEU          
SEQRES  11 H  194  GLU ASP LEU VAL PHE PRO SER GLU ILE VAL GLY LYS ARG          
SEQRES  12 H  194  ILE ARG VAL LYS LEU ASP GLY SER ARG LEU ILE LYS VAL          
SEQRES  13 H  194  HIS LEU ASP LYS ALA GLN GLN ASN ASN VAL GLU HIS LYS          
SEQRES  14 H  194  VAL GLU THR PHE SER GLY VAL TYR LYS LYS LEU THR GLY          
SEQRES  15 H  194  LYS ASP VAL ASN PHE GLU PHE PRO GLU PHE GLN LEU              
SEQRES   1 I  208  MET GLY ILE SER ARG ASP ASN TRP HIS LYS ARG ARG LYS          
SEQRES   2 I  208  THR GLY GLY LYS ARG LYS PRO TYR HIS LYS LYS ARG LYS          
SEQRES   3 I  208  TYR GLU LEU GLY ARG PRO ALA ALA ASN THR LYS ILE GLY          
SEQRES   4 I  208  PRO ARG ARG ILE HIS THR VAL GLY VAL ARG GLY GLY ASN          
SEQRES   5 I  208  LYS LYS TYR ARG ALA LEU ARG LEU ASP VAL GLY ASN PHE          
SEQRES   6 I  208  SER TRP GLY SER GLU CYS CYS THR ARG LYS THR ARG ILE          
SEQRES   7 I  208  ILE ASP VAL VAL TYR ASN ALA SER ASN ASN GLU LEU VAL          
SEQRES   8 I  208  ARG THR LYS THR LEU VAL LYS ASN CYS ILE VAL LEU ILE          
SEQRES   9 I  208  ASP SER THR PRO TYR ARG GLN TRP TYR GLU SER HIS TYR          
SEQRES  10 I  208  ALA LEU PRO LEU GLY ARG LYS LYS GLY ALA LYS LEU THR          
SEQRES  11 I  208  PRO GLU GLU GLU GLU ILE LEU ASN LYS LYS ARG SER LYS          
SEQRES  12 I  208  LYS ILE GLN LYS LYS TYR ASP GLU ARG LYS LYS ASN ALA          
SEQRES  13 I  208  LYS ILE SER SER LEU LEU GLU GLU GLN PHE GLN GLN GLY          
SEQRES  14 I  208  LYS LEU LEU ALA CYS ILE ALA SER ARG PRO GLY GLN CYS          
SEQRES  15 I  208  GLY ARG ALA ASP GLY TYR VAL LEU GLU GLY LYS GLU LEU          
SEQRES  16 I  208  GLU PHE TYR LEU ARG LYS ILE LYS ALA ARG LYS GLY LYS          
SEQRES   1 J  194  MET PRO VAL ALA ARG SER TRP VAL CYS ARG LYS THR TYR          
SEQRES   2 J  194  VAL THR PRO ARG ARG PRO PHE GLU LYS SER ARG LEU ASP          
SEQRES   3 J  194  GLN GLU LEU LYS LEU ILE GLY GLU TYR GLY LEU ARG ASN          
SEQRES   4 J  194  LYS ARG GLU VAL TRP ARG VAL LYS PHE THR LEU ALA LYS          
SEQRES   5 J  194  ILE ARG LYS ALA ALA ARG GLU LEU LEU THR LEU ASP GLU          
SEQRES   6 J  194  LYS ASP PRO ARG ARG LEU PHE GLU GLY ASN ALA LEU LEU          
SEQRES   7 J  194  ARG ARG LEU VAL ARG ILE GLY VAL LEU ASP GLU GLY LYS          
SEQRES   8 J  194  MET LYS LEU ASP TYR ILE LEU GLY LEU LYS ILE GLU ASP          
SEQRES   9 J  194  PHE LEU GLU ARG ARG LEU GLN THR GLN VAL PHE LYS LEU          
SEQRES  10 J  194  GLY LEU ALA LYS SER ILE HIS HIS ALA ARG VAL LEU ILE          
SEQRES  11 J  194  ARG GLN ARG HIS ILE ARG VAL ARG LYS GLN VAL VAL ASN          
SEQRES  12 J  194  ILE PRO SER PHE ILE VAL ARG LEU ASP SER GLN LYS HIS          
SEQRES  13 J  194  ILE ASP PHE SER LEU ARG SER PRO TYR GLY GLY GLY ARG          
SEQRES  14 J  194  PRO GLY ARG VAL LYS ARG LYS ASN ALA LYS LYS GLY GLN          
SEQRES  15 J  194  GLY GLY ALA GLY ALA GLY ASP ASP GLU GLU GLU ASP              
SEQRES   1 K  165  MET LEU MET PRO LYS LYS ASN ARG ILE ALA ILE TYR GLU          
SEQRES   2 K  165  LEU LEU PHE LYS GLU GLY VAL MET VAL ALA LYS LYS ASP          
SEQRES   3 K  165  VAL HIS MET PRO LYS HIS PRO GLU LEU ALA ASP LYS ASN          
SEQRES   4 K  165  VAL PRO ASN LEU HIS VAL MET LYS ALA MET GLN SER LEU          
SEQRES   5 K  165  LYS SER ARG GLY TYR VAL LYS GLU GLN PHE ALA TRP ARG          
SEQRES   6 K  165  HIS PHE TYR TRP TYR LEU THR ASN GLU GLY ILE GLN TYR          
SEQRES   7 K  165  LEU ARG ASP TYR LEU HIS LEU PRO PRO GLU ILE VAL PRO          
SEQRES   8 K  165  ALA THR LEU ARG ARG SER ARG PRO GLU THR GLY ARG PRO          
SEQRES   9 K  165  ARG PRO LYS GLY LEU GLU GLY GLU ARG PRO ALA ARG LEU          
SEQRES  10 K  165  THR ARG GLY GLU ALA ASP ARG ASP THR TYR ARG ARG SER          
SEQRES  11 K  165  ALA VAL PRO PRO GLY ALA ASP LYS LYS ALA GLU ALA GLY          
SEQRES  12 K  165  ALA GLY SER ALA THR GLU PHE GLN PHE ARG GLY GLY PHE          
SEQRES  13 K  165  GLY ARG GLY ARG GLY GLN PRO PRO GLN                          
SEQRES   1 L  158  MET ALA ASP ILE GLN THR GLU ARG ALA TYR GLN LYS GLN          
SEQRES   2 L  158  PRO THR ILE PHE GLN ASN LYS LYS ARG VAL LEU LEU GLY          
SEQRES   3 L  158  GLU THR GLY LYS GLU LYS LEU PRO ARG TYR TYR LYS ASN          
SEQRES   4 L  158  ILE GLY LEU GLY PHE LYS THR PRO LYS GLU ALA ILE GLU          
SEQRES   5 L  158  GLY THR TYR ILE ASP LYS LYS CYS PRO PHE THR GLY ASN          
SEQRES   6 L  158  VAL SER ILE ARG GLY ARG ILE LEU SER GLY VAL VAL THR          
SEQRES   7 L  158  LYS MET LYS MET GLN ARG THR ILE VAL ILE ARG ARG ASP          
SEQRES   8 L  158  TYR LEU HIS TYR ILE ARG LYS TYR ASN ARG PHE GLU LYS          
SEQRES   9 L  158  ARG HIS LYS ASN MET SER VAL HIS LEU SER PRO CYS PHE          
SEQRES  10 L  158  ARG ASP VAL GLN ILE GLY ASP ILE VAL THR VAL GLY GLU          
SEQRES  11 L  158  CYS ARG PRO LEU SER LYS THR VAL ARG PHE ASN VAL LEU          
SEQRES  12 L  158  LYS VAL THR LYS ALA ALA GLY THR LYS LYS GLN PHE GLN          
SEQRES  13 L  158  LYS PHE                                                      
SEQRES   1 M  132  MET ALA GLU GLU GLY ILE ALA ALA GLY GLY VAL MET ASP          
SEQRES   2 M  132  VAL ASN THR ALA LEU GLN GLU VAL LEU LYS THR ALA LEU          
SEQRES   3 M  132  ILE HIS ASP GLY LEU ALA ARG GLY ILE ARG GLU ALA ALA          
SEQRES   4 M  132  LYS ALA LEU ASP LYS ARG GLN ALA HIS LEU CYS VAL LEU          
SEQRES   5 M  132  ALA SER ASN CYS ASP GLU PRO MET TYR VAL LYS LEU VAL          
SEQRES   6 M  132  GLU ALA LEU CYS ALA GLU HIS GLN ILE ASN LEU ILE LYS          
SEQRES   7 M  132  VAL ASP ASP ASN LYS LYS LEU GLY GLU TRP VAL GLY LEU          
SEQRES   8 M  132  CYS LYS ILE ASP ARG GLU GLY LYS PRO ARG LYS VAL VAL          
SEQRES   9 M  132  GLY CYS SER CYS VAL VAL VAL LYS ASP TYR GLY LYS GLU          
SEQRES  10 M  132  SER GLN ALA LYS ASP VAL ILE GLU GLU TYR PHE LYS CYS          
SEQRES  11 M  132  LYS LYS                                                      
SEQRES   1 N  151  MET GLY ARG MET HIS ALA PRO GLY LYS GLY LEU SER GLN          
SEQRES   2 N  151  SER ALA LEU PRO TYR ARG ARG SER VAL PRO THR TRP LEU          
SEQRES   3 N  151  LYS LEU THR SER ASP ASP VAL LYS GLU GLN ILE TYR LYS          
SEQRES   4 N  151  LEU ALA LYS LYS GLY LEU THR PRO SER GLN ILE GLY VAL          
SEQRES   5 N  151  ILE LEU ARG ASP SER HIS GLY VAL ALA GLN VAL ARG PHE          
SEQRES   6 N  151  VAL THR GLY ASN LYS ILE LEU ARG ILE LEU LYS SER LYS          
SEQRES   7 N  151  GLY LEU ALA PRO ASP LEU PRO GLU ASP LEU TYR HIS LEU          
SEQRES   8 N  151  ILE LYS LYS ALA VAL ALA VAL ARG LYS HIS LEU GLU ARG          
SEQRES   9 N  151  ASN ARG LYS ASP LYS ASP ALA LYS PHE ARG LEU ILE LEU          
SEQRES  10 N  151  ILE GLU SER ARG ILE HIS ARG LEU ALA ARG TYR TYR LYS          
SEQRES  11 N  151  THR LYS ARG VAL LEU PRO PRO ASN TRP LYS TYR GLU SER          
SEQRES  12 N  151  SER THR ALA SER ALA LEU VAL ALA                              
SEQRES   1 O  151  MET ALA PRO ARG LYS GLY LYS GLU LYS LYS GLU GLU GLN          
SEQRES   2 O  151  VAL ILE SER LEU GLY PRO GLN VAL ALA GLU GLY GLU ASN          
SEQRES   3 O  151  VAL PHE GLY VAL CYS HIS ILE PHE ALA SER PHE ASN ASP          
SEQRES   4 O  151  THR PHE VAL HIS VAL THR ASP LEU SER GLY LYS GLU THR          
SEQRES   5 O  151  ILE CYS ARG VAL THR GLY GLY MET LYS VAL LYS ALA ASP          
SEQRES   6 O  151  ARG ASP GLU SER SER PRO TYR ALA ALA MET LEU ALA ALA          
SEQRES   7 O  151  GLN ASP VAL ALA GLN ARG CYS LYS GLU LEU GLY ILE THR          
SEQRES   8 O  151  ALA LEU HIS ILE LYS LEU ARG ALA THR GLY GLY ASN ARG          
SEQRES   9 O  151  THR LYS THR PRO GLY PRO GLY ALA GLN SER ALA LEU ARG          
SEQRES  10 O  151  ALA LEU ALA ARG SER GLY MET LYS ILE GLY ARG ILE GLU          
SEQRES  11 O  151  ASP VAL THR PRO ILE PRO SER ASP SER THR ARG ARG LYS          
SEQRES  12 O  151  GLY GLY ARG ARG GLY ARG ARG LEU                              
SEQRES   1 P  145  MET ALA GLU VAL GLU GLN LYS LYS LYS ARG THR PHE ARG          
SEQRES   2 P  145  LYS PHE THR TYR ARG GLY VAL ASP LEU ASP GLN LEU LEU          
SEQRES   3 P  145  ASP MET SER TYR GLU GLN LEU MET GLN LEU TYR SER ALA          
SEQRES   4 P  145  ARG GLN ARG ARG ARG LEU SER ARG GLY LEU ARG ARG LYS          
SEQRES   5 P  145  GLN HIS SER LEU LEU LYS ARG LEU ARG LYS ALA LYS LYS          
SEQRES   6 P  145  GLU ALA PRO PRO MET GLU LYS PRO GLU VAL VAL LYS THR          
SEQRES   7 P  145  HIS LEU ARG ASP MET ILE ILE LEU PRO GLU MET VAL GLY          
SEQRES   8 P  145  SER MET VAL GLY VAL TYR ASN GLY LYS THR PHE ASN GLN          
SEQRES   9 P  145  VAL GLU ILE LYS PRO GLU MET ILE GLY HIS TYR LEU GLY          
SEQRES  10 P  145  GLU PHE SER ILE THR TYR LYS PRO VAL LYS HIS GLY ARG          
SEQRES  11 P  145  PRO GLY ILE GLY ALA THR HIS SER SER ARG PHE ILE PRO          
SEQRES  12 P  145  LEU LYS                                                      
SEQRES   1 Q  146  MET PRO SER LYS GLY PRO LEU GLN SER VAL GLN VAL PHE          
SEQRES   2 Q  146  GLY ARG LYS LYS THR ALA THR ALA VAL ALA HIS CYS LYS          
SEQRES   3 Q  146  ARG GLY ASN GLY LEU ILE LYS VAL ASN GLY ARG PRO LEU          
SEQRES   4 Q  146  GLU MET ILE GLU PRO ARG THR LEU GLN TYR LYS LEU LEU          
SEQRES   5 Q  146  GLU PRO VAL LEU LEU LEU GLY LYS GLU ARG PHE ALA GLY          
SEQRES   6 Q  146  VAL ASP ILE ARG VAL ARG VAL LYS GLY GLY GLY HIS VAL          
SEQRES   7 Q  146  ALA GLN ILE TYR ALA ILE ARG GLN SER ILE SER LYS ALA          
SEQRES   8 Q  146  LEU VAL ALA TYR TYR GLN LYS TYR VAL ASP GLU ALA SER          
SEQRES   9 Q  146  LYS LYS GLU ILE LYS ASP ILE LEU ILE GLN TYR ASP ARG          
SEQRES  10 Q  146  THR LEU LEU VAL ALA ASP PRO ARG ARG CYS GLU SER LYS          
SEQRES  11 Q  146  LYS PHE GLY GLY PRO GLY ALA ARG ALA ARG TYR GLN LYS          
SEQRES  12 Q  146  SER TYR ARG                                                  
SEQRES   1 R  135  MET GLY ARG VAL ARG THR LYS THR VAL LYS LYS ALA ALA          
SEQRES   2 R  135  ARG VAL ILE ILE GLU LYS TYR TYR THR ARG LEU GLY ASN          
SEQRES   3 R  135  ASP PHE HIS THR ASN LYS ARG VAL CYS GLU GLU ILE ALA          
SEQRES   4 R  135  ILE ILE PRO SER LYS LYS LEU ARG ASN LYS ILE ALA GLY          
SEQRES   5 R  135  TYR VAL THR HIS LEU MET LYS ARG ILE GLN ARG GLY PRO          
SEQRES   6 R  135  VAL ARG GLY ILE SER ILE LYS LEU GLN GLU GLU GLU ARG          
SEQRES   7 R  135  GLU ARG ARG ASP ASN TYR VAL PRO GLU VAL SER ALA LEU          
SEQRES   8 R  135  ASP GLN GLU ILE ILE GLU VAL ASP PRO ASP THR LYS GLU          
SEQRES   9 R  135  MET LEU LYS LEU LEU ASP PHE GLY SER LEU SER ASN LEU          
SEQRES  10 R  135  GLN VAL THR GLN PRO THR VAL GLY MET ASN PHE LYS THR          
SEQRES  11 R  135  PRO ARG GLY ALA VAL                                          
SEQRES   1 S  152  MET SER LEU VAL ILE PRO GLU LYS PHE GLN HIS ILE LEU          
SEQRES   2 S  152  ARG VAL LEU ASN THR ASN ILE ASP GLY ARG ARG LYS ILE          
SEQRES   3 S  152  ALA PHE ALA ILE THR ALA ILE LYS GLY VAL GLY ARG ARG          
SEQRES   4 S  152  TYR ALA HIS VAL VAL LEU ARG LYS ALA ASP ILE ASP LEU          
SEQRES   5 S  152  THR LYS ARG ALA GLY GLU LEU THR GLU ASP GLU VAL GLU          
SEQRES   6 S  152  ARG VAL ILE THR ILE MET GLN ASN PRO ARG GLN TYR LYS          
SEQRES   7 S  152  ILE PRO ASP TRP PHE LEU ASN ARG GLN LYS ASP VAL LYS          
SEQRES   8 S  152  ASP GLY LYS TYR SER GLN VAL LEU ALA ASN GLY LEU ASP          
SEQRES   9 S  152  ASN LYS LEU ARG GLU ASP LEU GLU ARG LEU LYS LYS ILE          
SEQRES  10 S  152  ARG ALA HIS ARG GLY LEU ARG HIS PHE TRP GLY LEU ARG          
SEQRES  11 S  152  VAL ARG GLY GLN HIS THR LYS THR THR GLY ARG ARG GLY          
SEQRES  12 S  152  ARG THR VAL GLY VAL SER LYS LYS LYS                          
SEQRES   1 T  145  MET PRO GLY VAL THR VAL LYS ASP VAL ASN GLN GLN GLU          
SEQRES   2 T  145  PHE VAL ARG ALA LEU ALA ALA PHE LEU LYS LYS SER GLY          
SEQRES   3 T  145  LYS LEU LYS VAL PRO GLU TRP VAL ASP THR VAL LYS LEU          
SEQRES   4 T  145  ALA LYS HIS LYS GLU LEU ALA PRO TYR ASP GLU ASN TRP          
SEQRES   5 T  145  PHE TYR THR ARG ALA ALA SER THR ALA ARG HIS LEU TYR          
SEQRES   6 T  145  LEU ARG GLY GLY ALA GLY VAL GLY SER MET THR LYS ILE          
SEQRES   7 T  145  TYR GLY GLY ARG GLN ARG ASN GLY VAL MET PRO SER HIS          
SEQRES   8 T  145  PHE SER ARG GLY SER LYS SER VAL ALA ARG ARG VAL LEU          
SEQRES   9 T  145  GLN ALA LEU GLU GLY LEU LYS MET VAL GLU LYS ASP GLN          
SEQRES  10 T  145  ASP TRP GLY ARG LYS LEU THR PRO GLN GLY GLN ARG ASP          
SEQRES  11 T  145  LEU ASP ARG ILE ALA GLY GLN VAL ALA ALA ALA LYS LYS          
SEQRES  12 T  145  LYS HIS                                                      
SEQRES   1 U  119  MET ALA PHE LYS ASP THR GLY LYS THR PRO VAL GLU PRO          
SEQRES   2 U  119  GLU VAL ALA ILE HIS ARG ILE ARG ILE THR LEU THR SER          
SEQRES   3 U  119  ARG ASN VAL LYS SER LEU GLU LYS VAL CYS ALA ASP LEU          
SEQRES   4 U  119  ILE ARG GLY ALA LYS GLU LYS ASN LEU LYS VAL LYS GLY          
SEQRES   5 U  119  PRO VAL ARG MET PRO THR LYS THR LEU ARG ILE THR THR          
SEQRES   6 U  119  ARG LYS THR PRO CYS GLY GLU GLY SER LYS THR TRP ASP          
SEQRES   7 U  119  ARG PHE GLN MET ARG ILE HIS LYS ARG LEU ILE ASP LEU          
SEQRES   8 U  119  HIS SER PRO SER GLU ILE VAL LYS GLN ILE THR SER ILE          
SEQRES   9 U  119  SER ILE GLU PRO GLY VAL GLU VAL GLU VAL THR ILE ALA          
SEQRES  10 U  119  ASP ALA                                                      
SEQRES   1 V   83  MET GLN SER ASN ALA GLY GLU PHE VAL ASP LEU TYR VAL          
SEQRES   2 V   83  PRO ARG LYS CYS SER ALA SER ASN ARG ILE ILE GLY ALA          
SEQRES   3 V   83  LYS ASP HIS ALA SER ILE PRO MET ASN VAL ALA GLU VAL          
SEQRES   4 V   83  ASP LYS VAL THR GLY ARG PHE ASN GLY GLN SER LYS THR          
SEQRES   5 V   83  TYR ALA ILE CYS GLY ALA ILE ARG ARG MET GLY GLU SER          
SEQRES   6 V   83  ASP ASP SER ILE LEU ARG LEU ALA LYS SER HIS GLY ILE          
SEQRES   7 V   83  VAL SER GLN ASN PHE                                          
SEQRES   1 W  130  MET VAL ARG MET ASN VAL LEU ALA ASP ALA LEU LYS SER          
SEQRES   2 W  130  ILE ASN ASN ALA GLU LYS ARG GLY LYS ARG GLN VAL LEU          
SEQRES   3 W  130  ILE ARG PRO CYS SER LYS VAL ILE VAL ARG PHE LEU THR          
SEQRES   4 W  130  VAL MET MET LYS HIS GLY TYR ILE GLY GLU PHE GLU ILE          
SEQRES   5 W  130  ILE ASP ASP HIS ARG ALA GLY LYS ILE VAL VAL ASN LEU          
SEQRES   6 W  130  THR GLY ARG LEU ASN LYS CYS GLY VAL ILE SER PRO ARG          
SEQRES   7 W  130  PHE ASP VAL GLN LEU LYS ASP LEU GLU LYS TRP GLN ASN          
SEQRES   8 W  130  ASN LEU LEU PRO SER ARG GLN PHE GLY PHE ILE VAL LEU          
SEQRES   9 W  130  THR THR SER ALA GLY ILE MET ASP HIS GLU GLU ALA ARG          
SEQRES  10 W  130  ARG LYS HIS THR GLY GLY LYS ILE LEU GLY PHE PHE PHE          
SEQRES   1 X  143  MET GLY LYS CYS ARG GLY LEU ARG THR ALA ARG LYS LEU          
SEQRES   2 X  143  ARG SER HIS ARG ARG ASP GLN LYS TRP HIS ASP LYS GLN          
SEQRES   3 X  143  TYR LYS LYS ALA HIS LEU GLY THR ALA LEU LYS ALA ASN          
SEQRES   4 X  143  PRO PHE GLY GLY ALA SER HIS ALA LYS GLY ILE VAL LEU          
SEQRES   5 X  143  GLU LYS VAL GLY VAL GLU ALA LYS GLN PRO ASN SER ALA          
SEQRES   6 X  143  ILE ARG LYS CYS VAL ARG VAL GLN LEU ILE LYS ASN GLY          
SEQRES   7 X  143  LYS LYS ILE THR ALA PHE VAL PRO ASN ASP GLY CYS LEU          
SEQRES   8 X  143  ASN PHE ILE GLU GLU ASN ASP GLU VAL LEU VAL ALA GLY          
SEQRES   9 X  143  PHE GLY ARG LYS GLY HIS ALA VAL GLY ASP ILE PRO GLY          
SEQRES  10 X  143  VAL ARG PHE LYS VAL VAL LYS VAL ALA ASN VAL SER LEU          
SEQRES  11 X  143  LEU ALA LEU TYR LYS GLY LYS LYS GLU ARG PRO ARG SER          
SEQRES   1 Y  133  MET ASN ASP THR VAL THR ILE ARG THR ARG LYS PHE MET          
SEQRES   2 Y  133  THR ASN ARG LEU LEU GLN ARG LYS GLN MET VAL ILE ASP          
SEQRES   3 Y  133  VAL LEU HIS PRO GLY LYS ALA THR VAL PRO LYS THR GLU          
SEQRES   4 Y  133  ILE GLN GLU LYS LEU ALA LYS MET TYR LYS THR THR PRO          
SEQRES   5 Y  133  ASP VAL ILE PHE VAL PHE GLY PHE ARG THR HIS PHE GLY          
SEQRES   6 Y  133  GLY GLY LYS THR THR GLY PHE GLY MET ILE TYR ASP SER          
SEQRES   7 Y  133  LEU ASP TYR ALA LYS LYS ASN GLU PRO LYS HIS ARG LEU          
SEQRES   8 Y  133  ALA ARG HIS GLY LEU TYR GLU LYS LYS LYS THR SER ARG          
SEQRES   9 Y  133  LYS GLN ARG LYS GLU ARG LYS ASN ARG MET LYS LYS VAL          
SEQRES  10 Y  133  ARG GLY THR ALA LYS ALA ASN VAL GLY ALA GLY LYS LYS          
SEQRES  11 Y  133  PRO LYS GLU                                                  
SEQRES   1 Z  125  MET PRO PRO LYS ASP ASP LYS LYS LYS LYS ASP ALA GLY          
SEQRES   2 Z  125  LYS SER ALA LYS LYS ASP LYS ASP PRO VAL ASN LYS SER          
SEQRES   3 Z  125  GLY GLY LYS ALA LYS LYS LYS LYS TRP SER LYS GLY LYS          
SEQRES   4 Z  125  VAL ARG ASP LYS LEU ASN ASN LEU VAL LEU PHE ASP LYS          
SEQRES   5 Z  125  ALA THR TYR ASP LYS LEU CYS LYS GLU VAL PRO ASN TYR          
SEQRES   6 Z  125  LYS LEU ILE THR PRO ALA VAL VAL SER GLU ARG LEU LYS          
SEQRES   7 Z  125  ILE ARG GLY SER LEU ALA ARG ALA ALA LEU GLN GLU LEU          
SEQRES   8 Z  125  LEU SER LYS GLY LEU ILE LYS LEU VAL SER LYS HIS ARG          
SEQRES   9 Z  125  ALA GLN VAL ILE TYR THR ARG ASN THR LYS GLY GLY ASP          
SEQRES  10 Z  125  ALA PRO ALA ALA GLY GLU ASP ALA                              
SEQRES   1 a  115  MET THR LYS LYS ARG ARG ASN ASN GLY ARG ALA LYS LYS          
SEQRES   2 a  115  GLY ARG GLY HIS VAL GLN PRO ILE ARG CYS THR ASN CYS          
SEQRES   3 a  115  ALA CYS CYS VAL PRO LYS ASP LYS ALA ILE LYS LYS PHE          
SEQRES   4 a  115  VAL ILE ARG ASN ILE VAL GLU ALA ALA ALA VAL ARG ASP          
SEQRES   5 a  115  ILE SER GLU VAL SER VAL PHE ASP ALA TYR VAL LEU PRO          
SEQRES   6 a  115  LYS LEU TYR VAL LYS LEU HIS TYR CYS VAL SER CYS ALA          
SEQRES   7 a  115  ILE HIS SER LYS VAL VAL ARG ASN ARG SER ARG GLU ALA          
SEQRES   8 a  115  ARG LYS ASP ARG THR PRO PRO PRO ARG PHE ARG PRO ALA          
SEQRES   9 a  115  GLY ALA ALA PRO PRO PRO PRO PRO LYS PRO MET                  
SEQRES   1 b   84  MET PRO LEU ALA LYS ASP LEU LEU HIS PRO SER PRO GLU          
SEQRES   2 b   84  GLU GLU LYS ARG LYS HIS LYS LYS LYS ARG LEU VAL GLN          
SEQRES   3 b   84  SER PRO ASN SER TYR PHE MET ASP VAL LYS CYS PRO GLY          
SEQRES   4 b   84  CYS TYR LYS ILE THR THR VAL PHE SER HIS ALA GLN THR          
SEQRES   5 b   84  VAL VAL LEU CYS VAL GLY CYS SER THR VAL LEU CYS GLN          
SEQRES   6 b   84  PRO THR GLY GLY LYS ALA ARG LEU THR GLU GLY CYS SER          
SEQRES   7 b   84  PHE ARG ARG LYS GLN HIS                                      
SEQRES   1 c   69  MET ASP THR SER ARG VAL GLN PRO ILE LYS LEU ALA ARG          
SEQRES   2 c   69  VAL THR LYS VAL LEU GLY ARG THR GLY SER GLN GLY GLN          
SEQRES   3 c   69  CYS THR GLN VAL ARG VAL GLU PHE MET ASP ASP THR SER          
SEQRES   4 c   69  ARG SER ILE ILE ARG ASN VAL LYS GLY PRO VAL ARG GLU          
SEQRES   5 c   69  GLY ASP VAL LEU THR LEU LEU GLU SER GLU ARG GLU ALA          
SEQRES   6 c   69  ARG ARG LEU ARG                                              
SEQRES   1 d   56  MET GLY HIS GLN GLN LEU TYR TRP SER HIS PRO ARG LYS          
SEQRES   2 d   56  PHE GLY GLN GLY SER ARG SER CYS ARG VAL CYS SER ASN          
SEQRES   3 d   56  ARG HIS GLY LEU ILE ARG LYS TYR GLY LEU ASN MET CYS          
SEQRES   4 d   56  ARG GLN CYS PHE ARG GLN TYR ALA LYS ASP ILE GLY PHE          
SEQRES   5 d   56  ILE LYS LEU ASP                                              
SEQRES   1 e  133  MET GLN LEU PHE VAL ARG ALA GLN GLU LEU HIS THR LEU          
SEQRES   2 e  133  GLU VAL THR GLY ARG GLU THR VAL ALA GLN ILE LYS ALA          
SEQRES   3 e  133  HIS VAL ALA SER LEU GLU GLY ILE ALA PRO GLU ASP GLN          
SEQRES   4 e  133  VAL VAL LEU LEU ALA GLY THR PRO LEU GLU ASP GLU ALA          
SEQRES   5 e  133  THR LEU GLY GLN CYS GLY VAL GLU ALA LEU SER THR LEU          
SEQRES   6 e  133  GLU VAL ALA GLY ARG MET LEU GLY GLY LYS VAL HIS GLY          
SEQRES   7 e  133  SER LEU ALA ARG VAL GLY LYS VAL ARG GLY GLN THR LEU          
SEQRES   8 e  133  LYS VAL ALA LYS GLN GLU LYS LYS LYS LYS ARG THR GLY          
SEQRES   9 e  133  ARG ALA LYS ARG ARG MET GLN TYR ASN ARG ARG PHE VAL          
SEQRES  10 e  133  ASN VAL VAL PRO THR PHE GLY LYS LYS LYS GLY PRO ASN          
SEQRES  11 e  133  ALA ASN SER                                                  
SEQRES   1 f  156  MET GLN ILE PHE VAL LYS THR LEU THR GLY LYS THR ILE          
SEQRES   2 f  156  THR LEU GLU VAL GLU PRO SER ASP THR ILE GLU ASN VAL          
SEQRES   3 f  156  LYS ALA LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO ASP          
SEQRES   4 f  156  GLN GLN ARG LEU ILE PHE ALA GLY LYS GLN LEU GLU ASP          
SEQRES   5 f  156  GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS GLU SER          
SEQRES   6 f  156  THR LEU HIS LEU VAL LEU ARG LEU ARG GLY GLY ALA LYS          
SEQRES   7 f  156  LYS ARG LYS LYS LYS SER TYR THR THR PRO LYS LYS ASN          
SEQRES   8 f  156  LYS HIS LYS ARG LYS LYS VAL LYS LEU ALA VAL LEU LYS          
SEQRES   9 f  156  TYR TYR LYS VAL ASP GLU ASN GLY LYS ILE SER ARG LEU          
SEQRES  10 f  156  ARG ARG GLU CYS PRO SER ASP GLU CYS GLY ALA GLY VAL          
SEQRES  11 f  156  PHE MET ALA SER HIS PHE ASP ARG HIS TYR CYS GLY LYS          
SEQRES  12 f  156  CYS CYS LEU THR TYR CYS PHE ASN LYS PRO GLU ASP LYS          
SEQRES   1 g  317  MET THR GLU GLN MET THR LEU ARG GLY THR LEU LYS GLY          
SEQRES   2 g  317  HIS ASN GLY TRP VAL THR GLN ILE ALA THR THR PRO GLN          
SEQRES   3 g  317  PHE PRO ASP MET ILE LEU SER ALA SER ARG ASP LYS THR          
SEQRES   4 g  317  ILE ILE MET TRP LYS LEU THR ARG ASP GLU THR ASN TYR          
SEQRES   5 g  317  GLY ILE PRO GLN ARG ALA LEU ARG GLY HIS SER HIS PHE          
SEQRES   6 g  317  VAL SER ASP VAL VAL ILE SER SER ASP GLY GLN PHE ALA          
SEQRES   7 g  317  LEU SER GLY SER TRP ASP GLY THR LEU ARG LEU TRP ASP          
SEQRES   8 g  317  LEU THR THR GLY THR THR THR ARG ARG PHE VAL GLY HIS          
SEQRES   9 g  317  THR LYS ASP VAL LEU SER VAL ALA PHE SER SER ASP ASN          
SEQRES  10 g  317  ARG GLN ILE VAL SER GLY SER ARG ASP LYS THR ILE LYS          
SEQRES  11 g  317  LEU TRP ASN THR LEU GLY VAL CYS LYS TYR THR VAL GLN          
SEQRES  12 g  317  ASP GLU SER HIS SER GLU TRP VAL SER CYS VAL ARG PHE          
SEQRES  13 g  317  SER PRO ASN SER SER ASN PRO ILE ILE VAL SER CYS GLY          
SEQRES  14 g  317  TRP ASP LYS LEU VAL LYS VAL TRP ASN LEU ALA ASN CYS          
SEQRES  15 g  317  LYS LEU LYS THR ASN HIS ILE GLY HIS THR GLY TYR LEU          
SEQRES  16 g  317  ASN THR VAL THR VAL SER PRO ASP GLY SER LEU CYS ALA          
SEQRES  17 g  317  SER GLY GLY LYS ASP GLY GLN ALA MET LEU TRP ASP LEU          
SEQRES  18 g  317  ASN GLU GLY LYS HIS LEU TYR THR LEU ASP GLY GLY ASP          
SEQRES  19 g  317  ILE ILE ASN ALA LEU CYS PHE SER PRO ASN ARG TYR TRP          
SEQRES  20 g  317  LEU CYS ALA ALA THR GLY PRO SER ILE LYS ILE TRP ASP          
SEQRES  21 g  317  LEU GLU GLY LYS ILE ILE VAL ASP GLU LEU LYS GLN GLU          
SEQRES  22 g  317  VAL ILE SER THR SER SER LYS ALA GLU PRO PRO GLN CYS          
SEQRES  23 g  317  THR SER LEU ALA TRP SER ALA ASP GLY GLN THR LEU PHE          
SEQRES  24 g  317  ALA GLY TYR THR ASP ASN LEU VAL ARG VAL TRP GLN VAL          
SEQRES  25 g  317  THR ILE GLY THR ARG                                          
SEQRES   1 i 1863    U   A   C   C   U   G   G   U   U   G   A   U   C          
SEQRES   2 i 1863    C   U   G   C   C   A   G   U   A   G   C   A   U          
SEQRES   3 i 1863    A   U   G   C   U   U   G   U   C   U   C   A   A          
SEQRES   4 i 1863    A   G   A   U   U   A   A   G   C   C   A   U   G          
SEQRES   5 i 1863    C   A   U   G   U   C   U   A   A   G   U   A   C          
SEQRES   6 i 1863    G   C   A   C   G   G   C   C   G   G   U   A   C          
SEQRES   7 i 1863    A   G   U   G   A   A   A   C   U   G   C   G   A          
SEQRES   8 i 1863    A   U   G   G   C   U   C   A   U   U   A   A   A          
SEQRES   9 i 1863    U   C   A   G   U   U   A   U   G   G   U   U   C          
SEQRES  10 i 1863    C   U   U   U   G   G   U   C   G   C   U   C   G          
SEQRES  11 i 1863    C   U   C   C   U   C   U   C   C   U   A   C   U          
SEQRES  12 i 1863    U   G   G   A   U   A   A   C   U   G   U   G   G          
SEQRES  13 i 1863    U   A   A   U   U   C   U   A   G   A   G   C   U          
SEQRES  14 i 1863    A   A   U   A   C   A   U   G   C   C   G   A   C          
SEQRES  15 i 1863    G   G   C   G   C   U   G   A   C   U   C   C   C          
SEQRES  16 i 1863    U   U   U   G   U   G   U   G   G   G   A   U   G          
SEQRES  17 i 1863    C   G   U   G   C   A   U   U   U   A   U   C   A          
SEQRES  18 i 1863    G   A   U   C   A   A   A   A   C   C   A   A   C          
SEQRES  19 i 1863    C   C   G   G   U   C   A   G   C   C   U   C   C          
SEQRES  20 i 1863    C   C   G   C   C   G   G   C   C   G   G   G   G          
SEQRES  21 i 1863    G   G   G   U   G   G   G   G   C   G   G   C   G          
SEQRES  22 i 1863    G   C   U   U   U   G   G   U   G   A   C   U   C          
SEQRES  23 i 1863    U   A   G   A   U   A   A   C   C   U   C   G   G          
SEQRES  24 i 1863    G   C   C   G   A   U   C   G   C   A   G   C   C          
SEQRES  25 i 1863    C   U   C   C   G   U   G   G   C   G   G   C   G          
SEQRES  26 i 1863    A   C   G   A   C   C   C   A   U   U   C   G   A          
SEQRES  27 i 1863    A   C   G   U   C   U   G   C   C   C   U   A   U          
SEQRES  28 i 1863    C   A   A   C   U   U   U   C   G   A   U   G   G          
SEQRES  29 i 1863    U   A   G   U   C   G   C   C   G   U   G   C   C          
SEQRES  30 i 1863    U   A   C   C   A   U   G   G   U   G   A   C   C          
SEQRES  31 i 1863    A   C   G   G   G   U   G   A   C   G   G   G   G          
SEQRES  32 i 1863    A   A   U   C   A   G   G   G   U   U   C   G   A          
SEQRES  33 i 1863    U   U   C   C   G   G   A   G   A   G   G   G   A          
SEQRES  34 i 1863    G   C   C   U   G   A   G   A   A   A   C   G   G          
SEQRES  35 i 1863    C   U   A   C   C   A   C   A   U   C   C   A   A          
SEQRES  36 i 1863    G   G   A   A   G   G   C   A   G   C   A   G   G          
SEQRES  37 i 1863    C   G   C   G   C   A   A   A   U   U   A   C   C          
SEQRES  38 i 1863    C   A   C   U   C   C   C   G   A   C   C   C   G          
SEQRES  39 i 1863    G   G   G   A   G   G   U   A   G   U   G   A   C          
SEQRES  40 i 1863    G   A   A   A   A   A   U   A   A   C   A   A   U          
SEQRES  41 i 1863    A   C   A   G   G   A   C   U   C   U   U   U   C          
SEQRES  42 i 1863    G   A   G   G   C   C   C   U   G   U   A   A   U          
SEQRES  43 i 1863    U   G   G   A   A   U   G   A   G   U   C   C   A          
SEQRES  44 i 1863    C   U   U   U   A   A   A   U   C   C   U   U   U          
SEQRES  45 i 1863    A   A   C   G   A   G   G   A   U   C   C   A   U          
SEQRES  46 i 1863    U   G   G   A   G   G   G   C   A   A   G   U   C          
SEQRES  47 i 1863    U   G   G   U   C   G   C   A   G   C   A   G   C          
SEQRES  48 i 1863    C   G   C   G   G   U   A   A   U   U   C   C   A          
SEQRES  49 i 1863    G   C   U   C   C   A   A   U   A   G   C   G   U          
SEQRES  50 i 1863    A   U   A   U   U   A   A   A   G   U   U   G   C          
SEQRES  51 i 1863    U   G   C   A   G   U   U   A   A   A   A   A   G          
SEQRES  52 i 1863    C   U   C   G   U   A   G   U   U   G   G   A   U          
SEQRES  53 i 1863    C   U   U   G   U   G   G   A   G   G   G   U   G          
SEQRES  54 i 1863    C   G   U   A   G   C   G   G   G   C   G   G   U          
SEQRES  55 i 1863    C   C   G   C   C   G   C   G   A   G   G   C   G          
SEQRES  56 i 1863    A   G   C   C   A   C   C   G   C   C   C   G   U          
SEQRES  57 i 1863    C   C   C   C   G   C   C   C   C   U   U   G   C          
SEQRES  58 i 1863    C   U   C   U   C   G   G   C   G   C   C   C   C          
SEQRES  59 i 1863    C   U   C   G   A   U   G   C   U   C   U   U   A          
SEQRES  60 i 1863    G   C   U   G   A   G   U   G   U   C   C   C   G          
SEQRES  61 i 1863    C   G   G   G   G   C   C   C   G   A   A   G   C          
SEQRES  62 i 1863    G   U   U   U   A   C   U   U   U   G   A   A   A          
SEQRES  63 i 1863    A   A   A   U   U   A   G   A   G   U   G   U   U          
SEQRES  64 i 1863    C   A   A   A   G   C   A   G   G   C   C   C   G          
SEQRES  65 i 1863    A   G   C   C   G   C   C   U   G   G   A   U   A          
SEQRES  66 i 1863    C   C   G   C   A   G   C   U   A   G   G   A   A          
SEQRES  67 i 1863    U   A   A   U   G   G   A   A   U   A   G   G   A          
SEQRES  68 i 1863    C   C   G   C   G   G   U   U   C   U   A   U   U          
SEQRES  69 i 1863    U   U   G   U   U   G   G   U   U   U   U   C   G          
SEQRES  70 i 1863    G   A   A   C   U   G   A   G   G   C   C   A   U          
SEQRES  71 i 1863    G   A   U   U   A   A   G   A   G   G   G   A   C          
SEQRES  72 i 1863    G   G   C   C   G   G   G   G   G   C   A   U   U          
SEQRES  73 i 1863    C   G   U   A   U   U   G   C   G   C   C   G   C          
SEQRES  74 i 1863    U   A   G   A   G   G   U   G   A   A   A   U   U          
SEQRES  75 i 1863    C   U   U   G   G   A   C   C   G   G   C   G   C          
SEQRES  76 i 1863    A   A   G   A   C   G   G   A   C   C   A   G   A          
SEQRES  77 i 1863    G   C   G   A   A   A   G   C   A   U   U   U   G          
SEQRES  78 i 1863    C   C   A   A   G   A   A   U   G   U   U   U   U          
SEQRES  79 i 1863    C   A   U   U   A   A   U   C   A   A   G   A   A          
SEQRES  80 i 1863    C   G   A   A   A   G   U   C   G   G   A   G   G          
SEQRES  81 i 1863    U   U   C   G   A   A   G   A   C   G   A   U   C          
SEQRES  82 i 1863    A   G   A   U   A   C   C   G   U   C   G   U   A          
SEQRES  83 i 1863    G   U   U   C   C   G   A   C   C   A   U   A   A          
SEQRES  84 i 1863    A   C   G   A   U   G   C   C   G   A   C   U   G          
SEQRES  85 i 1863    G   C   G   A   U   G   C   G   G   C   G   G   C          
SEQRES  86 i 1863    G   U   U   A   U   U   C   C   C   A   U   G   A          
SEQRES  87 i 1863    C   C   C   G   C   C   G   G   G   C   A   G   C          
SEQRES  88 i 1863    U   U   C   C   G   G   G   A   A   A   C   C   A          
SEQRES  89 i 1863    A   A   G   U   C   U   U   U   G   G   G   U   U          
SEQRES  90 i 1863    C   C   G   G   G   G   G   G   A   G   U   A   U          
SEQRES  91 i 1863    G   G   U   U   G   C   A   A   A   G   C   U   G          
SEQRES  92 i 1863    A   A   A   C   U   U   A   A   A   G   G   A   A          
SEQRES  93 i 1863    U   U   G   A   C   G   G   A   A   G   G   G   C          
SEQRES  94 i 1863    A   C   C   A   C   C   A   G   G   A   G   U   G          
SEQRES  95 i 1863    G   A   G   C   C   U   G   C   G   G   C   U   U          
SEQRES  96 i 1863    A   A   U   U   U   G   A   C   U   C   A   A   C          
SEQRES  97 i 1863    A   C   G   G   G   A   A   A   C   C   U   C   A          
SEQRES  98 i 1863    C   C   C   G   G   C   C   C   G   G   A   C   A          
SEQRES  99 i 1863    C   G   G   A   C   A   G   G   A   U   U   G   A          
SEQRES 100 i 1863    C   A   G   A   U   U   G   A   U   A   G   C   U          
SEQRES 101 i 1863    C   U   U   U   C   U   C   G   A   U   U   C   U          
SEQRES 102 i 1863    G   U   G   G   G   U   G   G   U   G   G   U   G          
SEQRES 103 i 1863    C   A   U   G   G   C   C   G   U   U   C   U   U          
SEQRES 104 i 1863    A   G   U   U   G   G   U   G   G   A   G   C   G          
SEQRES 105 i 1863    A   U   U   U   G   U   C   U   G   G   U   U   A          
SEQRES 106 i 1863    A   U   U   C   C   G   A   U   A   A   C   G   A          
SEQRES 107 i 1863    A   C   G   A   G   A   C   U   C   U   G   G   C          
SEQRES 108 i 1863    A   U   G   C   U   A   A   C   U   A   G   U   U          
SEQRES 109 i 1863    A   C   G   C   G   A   C   C   C   C   C   G   A          
SEQRES 110 i 1863    G   C   G   G   U   C   G   G   C   G   U   C   C          
SEQRES 111 i 1863    C   C   C   A   A   C   U   U   C   U   U   A   G          
SEQRES 112 i 1863    A   G   G   G   A   C   A   A   G   U   G   G   C          
SEQRES 113 i 1863    G   U   U   C   A   G   C   C   A   C   C   C   G          
SEQRES 114 i 1863    A   G   A   U   U   G   A   G   C   A   A   U   A          
SEQRES 115 i 1863    A   C   A   G   G   U   C   U   G   U   G   A   U          
SEQRES 116 i 1863    G   C   C   C   U   U   A   G   A   U   G   U   C          
SEQRES 117 i 1863    G   G   G   G   C   U   G   C   A   C   G   C   G          
SEQRES 118 i 1863    C   G   C   U   A   C   A   C   U   G   A   C   U          
SEQRES 119 i 1863    G   G   C   U   C   A   G   C   G   U   G   U   G          
SEQRES 120 i 1863    C   C   U   A   C   C   C   U   A   C   G   C   C          
SEQRES 121 i 1863    G   G   C   A   G   G   C   G   C   G   G   G   U          
SEQRES 122 i 1863    A   A   C   C   C   G   U   U   G   A   A   C   C          
SEQRES 123 i 1863    C   C   A   U   U   C   G   U   G   A   U   G   G          
SEQRES 124 i 1863    G   G   A   U   C   G   G   G   G   A   U   U   G          
SEQRES 125 i 1863    C   A   A   U   U   A   U   U   C   C   C   C   A          
SEQRES 126 i 1863    U   G   A   A   C   G   A   G   G   A   A   U   U          
SEQRES 127 i 1863    C   C   C   A   G   U   A   A   G   U   G   C   G          
SEQRES 128 i 1863    G   G   U   C   A   U   A   A   G   C   U   U   G          
SEQRES 129 i 1863    C   G   U   U   G   A   U   U   A   A   G   U   C          
SEQRES 130 i 1863    C   C   U   G   C   C   C   U   U   U   G   U   A          
SEQRES 131 i 1863    C   A   C   A   C   C   G   C   C   C   G   U   C          
SEQRES 132 i 1863    G   C   U   A   C   U   A   C   C   G   A   U   U          
SEQRES 133 i 1863    G   G   A   U   G   G   U   U   U   A   G   U   G          
SEQRES 134 i 1863    A   G   G   C   C   C   U   C   G   G   A   U   C          
SEQRES 135 i 1863    G   G   C   C   C   G   C   C   G   G   G   G   U          
SEQRES 136 i 1863    C   G   G   C   C   C   A   C   G   G   C   C   C          
SEQRES 137 i 1863    U   G   G   C   G   G   A   G   C   G   C   U   G          
SEQRES 138 i 1863    A   G   A   A   G   A   C   G   G   U   C   G   A          
SEQRES 139 i 1863    A   C   U   U   G   A   C   U   A   U   C   U   A          
SEQRES 140 i 1863    G   A   G   G   A   A   G   U   A   A   A   A   G          
SEQRES 141 i 1863    U   C   G   U   A   A   C   A   A   G   G   U   U          
SEQRES 142 i 1863    U   C   C   G   U   A   G   G   U   G   A   A   C          
SEQRES 143 i 1863    C   U   G   C   G   G   A   A   G   G   A   U   C          
SEQRES 144 i 1863    A   U   U   A                                              
SEQRES   1 l  113  MET SER ALA ILE GLN ASN LEU HIS SER PHE ASP PRO PHE          
SEQRES   2 l  113  ALA ASP ALA SER LYS GLY ASP ASP LEU LEU PRO ALA GLY          
SEQRES   3 l  113  THR GLU ASP TYR ILE HIS ILE ARG ILE GLN GLN ARG ASN          
SEQRES   4 l  113  GLY ARG LYS THR LEU THR THR VAL GLN GLY ILE ALA ASP          
SEQRES   5 l  113  ASP TYR ASP LYS LYS LYS LEU VAL LYS ALA PHE LYS LYS          
SEQRES   6 l  113  LYS PHE ALA CYS ASN GLY THR VAL ILE GLU HIS PRO GLU          
SEQRES   7 l  113  TYR GLY GLU VAL ILE GLN LEU GLN GLY ASP GLN ARG LYS          
SEQRES   8 l  113  ASN ILE CYS GLN PHE LEU VAL GLU ILE GLY LEU ALA LYS          
SEQRES   9 l  113  ASP ASP GLN LEU LYS VAL HIS GLY PHE                          
HELIX    1   1 LYS A   11  GLY A   22  1                                  12    
HELIX    2   2 MET A   34  GLN A   36  5                                   3    
HELIX    3   3 ASN A   50  VAL A   66  1                                  17    
HELIX    4   4 ASN A   70  ASP A   73  5                                   4    
HELIX    5   5 ARG A   80  THR A   82  5                                   3    
HELIX    6   6 GLY A   83  THR A   94  1                                  12    
HELIX    7   7 ASP A  130  SER A  138  1                                   9    
HELIX    8   8 GLY A  167  MET A  185  1                                  19    
HELIX    9   9 MET A  198  TYR A  202  5                                   5    
HELIX   10  10 LEU B   71  ASN B   76  1                                   6    
HELIX   11  11 ARG B  107  VAL B  114  1                                   8    
HELIX   12  12 GLN B  157  THR B  178  1                                  22    
HELIX   13  13 ASP B  180  ILE B  189  1                                  10    
HELIX   14  14 ASP B  191  GLN B  202  1                                  12    
HELIX   15  15 GLU B  224  HIS B  232  1                                   9    
HELIX   16  16 THR C   49  ASP C   57  1                                   9    
HELIX   17  17 SER C   62  SER C   70  1                                   9    
HELIX   18  18 GLU C   75  LEU C   83  1                                   9    
HELIX   19  19 GLU C  131  SER C  146  1                                  16    
HELIX   20  20 ALA C  192  GLY C  203  1                                  12    
HELIX   21  21 CYS C  214  THR C  217  5                                   4    
HELIX   22  22 LEU C  218  TYR C  235  1                                  18    
HELIX   23  23 THR C  237  LYS C  242  5                                   6    
HELIX   24  24 SER C  249  PHE C  254  1                                   6    
HELIX   25  25 SER D    6  LEU D   29  1                                  24    
HELIX   26  26 ARG D   54  GLY D   60  1                                   7    
HELIX   27  27 ARG D   64  PHE D   77  1                                  14    
HELIX   28  28 ALA D   98  GLY D  112  1                                  15    
HELIX   29  29 VAL D  115  GLY D  130  1                                  16    
HELIX   30  30 ASP D  162  TYR D  167  1                                   6    
HELIX   31  31 PRO D  191  GLY D  196  1                                   6    
HELIX   32  32 PRO E   15  MET E   19  5                                   5    
HELIX   33  33 LYS E   37  CYS E   41  5                                   5    
HELIX   34  34 LEU E   44  LYS E   51  1                                   8    
HELIX   35  35 THR E   57  GLN E   67  1                                  11    
HELIX   36  36 THR E  247  LYS E  259  1                                  13    
HELIX   37  37 PHE F   61  CYS F   66  5                                   6    
HELIX   38  38 PRO F   67  MET F   77  1                                  11    
HELIX   39  39 HIS F   79  ASN F   83  5                                   5    
HELIX   40  40 LYS F   85  GLY F  105  1                                  21    
HELIX   41  41 ASN F  107  GLY F  120  1                                  14    
HELIX   42  42 SER F  142  PHE F  163  1                                  22    
HELIX   43  43 THR F  168  LYS F  182  1                                  15    
HELIX   44  44 SER F  187  SER F  202  1                                  16    
HELIX   45  45 ASP G   20  THR G   26  1                                   7    
HELIX   46  46 ASP G   39  GLY G   42  5                                   4    
HELIX   47  47 GLN G   59  PHE G   61  5                                   3    
HELIX   48  48 ILE G  121  ASP G  126  1                                   6    
HELIX   49  49 ARG G  137  ASN G  146  1                                  10    
HELIX   50  50 THR G  181  ALA G  229  1                                  49    
HELIX   51  51 ALA G  229  LEU G  237  1                                   9    
HELIX   52  52 ALA H    6  LYS H   10  1                                   5    
HELIX   53  53 GLU H   18  MET H   32  1                                  15    
HELIX   54  54 GLN H   68  GLN H   76  1                                   9    
HELIX   55  55 GLN H   76  PHE H   87  1                                  12    
HELIX   56  56 THR H  121  VAL H  134  1                                  14    
HELIX   57  57 GLN H  163  HIS H  168  1                                   6    
HELIX   58  58 LYS H  169  GLY H  182  1                                  14    
HELIX   59  59 ARG I   25  LEU I   29  5                                   5    
HELIX   60  60 ASN I   87  THR I   93  1                                   7    
HELIX   61  61 SER I  106  ALA I  118  1                                  13    
HELIX   62  62 LYS I  125  THR I  130  1                                   6    
HELIX   63  63 GLU I  133  LYS I  139  1                                   7    
HELIX   64  64 ILE I  145  ARG I  152  1                                   8    
HELIX   65  65 LYS I  154  ILE I  158  5                                   5    
HELIX   66  66 SER I  159  GLY I  169  1                                  11    
HELIX   67  67 ARG I  178  GLY I  183  1                                   6    
HELIX   68  68 GLU I  191  LYS I  206  1                                  16    
HELIX   69  69 LYS J   22  TYR J   35  1                                  14    
HELIX   70  70 ASN J   39  LEU J   63  1                                  25    
HELIX   71  71 ASP J   67  ILE J   84  1                                  18    
HELIX   72  72 LYS J   93  LEU J   98  1                                   6    
HELIX   73  73 GLY J   99  LYS J  101  5                                   3    
HELIX   74  74 ILE J  102  GLU J  107  1                                   6    
HELIX   75  75 GLN J  111  LEU J  117  1                                   7    
HELIX   76  76 SER J  122  GLN J  132  1                                  11    
HELIX   77  77 ARG J  150  LYS J  155  5                                   6    
HELIX   78  78 VAL J  173  LYS J  179  1                                   7    
HELIX   79  79 LYS K    6  GLY K   19  1                                  14    
HELIX   80  80 HIS K   44  ARG K   55  1                                  12    
HELIX   81  81 THR K   72  HIS K   84  1                                  13    
HELIX   82  82 PRO L   47  GLY L   53  1                                   7    
HELIX   83  83 ASN M   15  ASP M   29  1                                  15    
HELIX   84  84 GLY M   34  ASP M   43  1                                  10    
HELIX   85  85 PRO M   59  GLU M   71  1                                  13    
HELIX   86  86 ASP M   81  VAL M   89  1                                   9    
HELIX   87  87 SER M  118  CYS M  130  1                                  13    
HELIX   88  88 THR N   29  LYS N   43  1                                  15    
HELIX   89  89 THR N   46  HIS N   58  1                                  13    
HELIX   90  90 GLN N   62  THR N   67  1                                   6    
HELIX   91  91 LYS N   70  GLY N   79  1                                  10    
HELIX   92  92 PRO N   85  ASN N  105  1                                  21    
HELIX   93  93 ASP N  108  LYS N  132  1                                  25    
HELIX   94  94 GLU N  142  ALA N  151  1                                  10    
HELIX   95  95 SER O   70  GLY O   89  1                                  20    
HELIX   96  96 GLY O  109  GLY O  111  5                                   3    
HELIX   97  97 ALA O  112  GLY O  123  1                                  12    
HELIX   98  98 ASP P   21  ASP P   27  1                                   7    
HELIX   99  99 SER P   29  GLN P   35  1                                   7    
HELIX  100 100 ALA P   39  LEU P   49  1                                  11    
HELIX  101 101 GLN P   53  ALA P   67  1                                  15    
HELIX  102 102 LYS P  108  ILE P  112  5                                   5    
HELIX  103 103 TYR P  115  SER P  120  5                                   6    
HELIX  104 104 GLN Q   48  LEU Q   58  1                                  11    
HELIX  105 105 ARG Q   62  ALA Q   64  5                                   3    
HELIX  106 106 GLY Q   76  TYR Q   99  1                                  24    
HELIX  107 107 ASP Q  101  ASP Q  116  1                                  16    
HELIX  108 108 THR R    6  TYR R   21  1                                  16    
HELIX  109 109 ASP R   27  ILE R   38  1                                  12    
HELIX  110 110 SER R   43  GLN R   62  1                                  20    
HELIX  111 111 ILE R   71  ASP R   82  1                                  12    
HELIX  112 112 ASP R  101  LEU R  108  1                                   8    
HELIX  113 113 LYS S   25  THR S   31  1                                   7    
HELIX  114 114 GLY S   37  ALA S   48  1                                  12    
HELIX  115 115 THR S   60  GLN S   72  1                                  13    
HELIX  116 116 ASN S   73  LYS S   78  5                                   6    
HELIX  117 117 ALA S  100  ILE S  117  1                                  18    
HELIX  118 118 ALA S  119  GLY S  128  1                                  10    
HELIX  119 119 THR T    5  VAL T    9  5                                   5    
HELIX  120 120 ASN T   10  GLY T   26  1                                  17    
HELIX  121 121 TRP T   52  ARG T   67  1                                  16    
HELIX  122 122 GLY T   71  GLY T   80  1                                  10    
HELIX  123 123 LYS T   97  LYS T  111  1                                  15    
HELIX  124 124 THR T  124  LYS T  142  1                                  19    
HELIX  125 125 ASN U   28  LYS U   46  1                                  19    
HELIX  126 126 PRO U   94  ILE U  104  1                                  11    
HELIX  127 127 CYS V   56  MET V   62  1                                   7    
HELIX  128 128 SER V   65  HIS V   76  1                                  12    
HELIX  129 129 VAL W    6  GLY W   21  1                                  16    
HELIX  130 130 SER W   31  GLY W   45  1                                  15    
HELIX  131 131 ASP W   85  LEU W   94  1                                  10    
HELIX  132 132 HIS W  113  HIS W  120  1                                   8    
HELIX  133 133 THR X    9  TRP X   22  1                                  14    
HELIX  134 134 ASP X   24  LEU X   32  1                                   9    
HELIX  135 135 GLY X   33  ALA X   38  1                                   6    
HELIX  136 136 CYS X   90  ILE X   94  5                                   5    
HELIX  137 137 SER X  129  LYS X  135  1                                   7    
HELIX  138 138 ARG Y   16  LEU Y   18  5                                   3    
HELIX  139 139 PRO Y   36  LYS Y   46  1                                  11    
HELIX  140 140 THR Y   51  ILE Y   55  5                                   5    
HELIX  141 141 SER Y   78  GLU Y   86  1                                   9    
HELIX  142 142 PRO Y   87  HIS Y   94  1                                   8    
HELIX  143 143 ARG Y  104  VAL Y  117  1                                  14    
HELIX  144 144 ALA Y  121  GLY Y  128  1                                   8    
HELIX  145 145 LYS Z   52  VAL Z   62  1                                  11    
HELIX  146 146 THR Z   69  LEU Z   77  1                                   9    
HELIX  147 147 GLY Z   81  LEU Z   92  1                                  12    
HELIX  148 148 ALA a   49  SER a   57  1                                   9    
HELIX  149 149 CYS a   74  SER a   81  1                                   8    
HELIX  150 150 GLU a   90  ASP a   94  5                                   5    
HELIX  151 151 SER b   11  LYS b   16  1                                   6    
HELIX  152 152 GLY d   15  ARG d   19  5                                   5    
HELIX  153 153 ARG d   32  LEU d   36  5                                   5    
HELIX  154 154 ARG d   40  GLY d   51  1                                  12    
HELIX  155 155 GLY e   84  THR e   90  1                                   7    
HELIX  156 156 THR e  103  PHE e  116  1                                  14    
HELIX  157 157 LEU l   59  ALA l   62  5                                   4    
HELIX  158 158 PHE l   63  ALA l   68  1                                   6    
SHEET    1   A 3 LEU A  25  GLY A  26  0                                        
SHEET    2   A 3 ILE A  46  ILE A  49 -1  O  TYR A  47   N  GLY A  26           
SHEET    3   A 3 ILE A  38  LYS A  42 -1  N  LYS A  40   O  ILE A  48           
SHEET    1   B 5 THR A  97  ALA A 100  0                                        
SHEET    2   B 5 SER A  75  SER A  78  1  N  VAL A  76   O  ILE A  99           
SHEET    3   B 5 LEU A 122  VAL A 124  1  O  VAL A 123   N  SER A  75           
SHEET    4   B 5 THR A 144  CYS A 148  1  O  ILE A 145   N  LEU A 122           
SHEET    5   B 5 ILE A 161  PRO A 162  1  O  ILE A 161   N  CYS A 148           
SHEET    1   C 5 ASN B  43  THR B  50  0                                        
SHEET    2   C 5 LYS B  28  LYS B  34 -1  N  ASP B  29   O  VAL B  49           
SHEET    3   C 5 ASN B  95  ASP B 104  1  O  CYS B  96   N  LYS B  34           
SHEET    4   C 5 LYS B  83  GLN B  92 -1  N  GLN B  92   O  ASN B  95           
SHEET    5   C 5 VAL B  66  SER B  70 -1  N  PHE B  67   O  LEU B  86           
SHEET    1   D 6 ASN B  43  THR B  50  0                                        
SHEET    2   D 6 LYS B  28  LYS B  34 -1  N  ASP B  29   O  VAL B  49           
SHEET    3   D 6 ASN B  95  ASP B 104  1  O  CYS B  96   N  LYS B  34           
SHEET    4   D 6 HIS B 208  LYS B 219 -1  O  VAL B 215   N  MET B 103           
SHEET    5   D 6 LEU B 134  PHE B 142 -1  N  HIS B 136   O  LYS B 216           
SHEET    6   D 6 MET B 120  LYS B 128 -1  N  VAL B 125   O  LEU B 137           
SHEET    1   E 3 LYS C  88  LYS C  93  0                                        
SHEET    2   E 3 ARG C 108  GLY C 116 -1  O  PHE C 112   N  LEU C  92           
SHEET    3   E 3 PRO C  96  VAL C  97 -1  N  VAL C  97   O  ARG C 108           
SHEET    1   F 4 LYS C  88  LYS C  93  0                                        
SHEET    2   F 4 ARG C 108  GLY C 116 -1  O  PHE C 112   N  LEU C  92           
SHEET    3   F 4 HIS C 121  SER C 129 -1  O  GLY C 125   N  VAL C 113           
SHEET    4   F 4 VAL C 148  PRO C 149 -1  O  VAL C 148   N  VAL C 122           
SHEET    1   G 4 VAL C 169  CYS C 173  0                                        
SHEET    2   G 4 VAL C 176  PRO C 182 -1  O  VAL C 178   N  GLY C 171           
SHEET    3   G 4 CYS C 207  GLY C 212 -1  O  TYR C 208   N  ILE C 181           
SHEET    4   G 4 ILE C 189  ILE C 190  1  N  ILE C 190   O  CYS C 207           
SHEET    1   H 3 TYR D  34  VAL D  41  0                                        
SHEET    2   H 3 THR D  46  ALA D  52 -1  O  ILE D  49   N  GLU D  38           
SHEET    3   H 3 VAL D  84  GLU D  89  1  O  GLU D  85   N  THR D  46           
SHEET    1   I 4 LYS D 148  GLY D 155  0                                        
SHEET    2   I 4 GLY D 133  GLY D 140 -1  N  VAL D 136   O  PHE D 152           
SHEET    3   I 4 VAL D 181  MET D 189 -1  O  MET D 189   N  GLY D 133           
SHEET    4   I 4 VAL D 168  LEU D 176 -1  N  ARG D 173   O  ILE D 184           
SHEET    1   J 2 SER D 209  ILE D 210  0                                        
SHEET    2   J 2 ALA R  39  ILE R  40 -1  O  ILE R  40   N  SER D 209           
SHEET    1   K 2 LEU E  42  PRO E  43  0                                        
SHEET    2   K 2 PRO E  83  ALA E  84 -1  O  ALA E  84   N  LEU E  42           
SHEET    1   L 4 ILE E  70  LYS E  71  0                                        
SHEET    2   L 4 SER E  91  ILE E  92 -1  O  SER E  91   N  LYS E  71           
SHEET    3   L 4 GLU E  97  PHE E  99 -1  O  GLU E  97   N  ILE E  92           
SHEET    4   L 4 ARG E 113  ILE E 114 -1  O  ILE E 114   N  ASN E  98           
SHEET    1   M 2 ILE E 102  TYR E 103  0                                        
SHEET    2   M 2 PHE E 109  ALA E 110 -1  O  ALA E 110   N  ILE E 102           
SHEET    1   N 5 THR E 146  ARG E 148  0                                        
SHEET    2   N 5 PRO E 137  THR E 141 -1  N  LEU E 139   O  ILE E 147           
SHEET    3   N 5 LYS E 122  VAL E 131 -1  N  ARG E 127   O  VAL E 140           
SHEET    4   N 5 THR E 159  ILE E 162 -1  O  ILE E 160   N  CYS E 124           
SHEET    5   N 5 ILE E 169  ILE E 173 -1  O  THR E 170   N  GLN E 161           
SHEET    1   O 4 ILE E 192  GLY E 193  0                                        
SHEET    2   O 4 ASN E 179  VAL E 183 -1  N  CYS E 181   O  GLY E 193           
SHEET    3   O 4 ILE E 225  LYS E 230 -1  O  PHE E 226   N  MET E 182           
SHEET    4   O 4 LYS E 233  PRO E 234 -1  O  LYS E 233   N  LYS E 230           
SHEET    1   P 3 THR E 196  GLU E 199  0                                        
SHEET    2   P 3 VAL E 207  LYS E 211 -1  O  HIS E 209   N  ASN E 197           
SHEET    3   P 3 SER E 217  ARG E 221 -1  O  PHE E 218   N  VAL E 210           
SHEET    1   Q 2 GLU F 123  THR F 126  0                                        
SHEET    2   Q 2 GLN F 137  ASP F 140 -1  O  VAL F 139   N  ASP F 124           
SHEET    1   R 5 CYS G  12  GLU G  17  0                                        
SHEET    2   R 5 LYS G   2  PHE G   7 -1  N  ILE G   5   O  LYS G  14           
SHEET    3   R 5 LEU G 106  LYS G 115  1  O  LEU G 109   N  ASN G   4           
SHEET    4   R 5 VAL G  49  ASP G  57 -1  N  SER G  53   O  ASN G 110           
SHEET    5   R 5 GLU G  35  ALA G  37 -1  N  VAL G  36   O  VAL G  50           
SHEET    1   S 2 ARG G  72  LEU G  77  0                                        
SHEET    2   S 2 LYS G  93  ARG G  98 -1  O  LYS G  95   N  LEU G  75           
SHEET    1   T 3 ALA H  48  GLU H  52  0                                        
SHEET    2   T 3 LYS H  58  VAL H  64 -1  O  ALA H  59   N  ILE H  51           
SHEET    3   T 3 LYS H  90  ALA H  96  1  O  ILE H  95   N  ILE H  62           
SHEET    1   U 6 ASP H 184  GLU H 188  0                                        
SHEET    2   U 6 ARG H 152  LEU H 158  1  N  VAL H 156   O  ASN H 186           
SHEET    3   U 6 ILE H 139  VAL H 146 -1  N  ARG H 145   O  LEU H 153           
SHEET    4   U 6 PHE W  50  ILE W  53 -1  O  PHE W  50   N  VAL H 146           
SHEET    5   U 6 LYS W  60  ASN W  64 -1  O  LYS W  60   N  ILE W  53           
SHEET    6   U 6 GLN W  24  ILE W  27 -1  N  ILE W  27   O  ILE W  61           
SHEET    1   V 2 ILE I  43  GLY I  47  0                                        
SHEET    2   V 2 LYS I  53  ALA I  57 -1  O  ARG I  56   N  HIS I  44           
SHEET    1   W 6 CYS I  72  ARG I  77  0                                        
SHEET    2   W 6 VAL I  62  TRP I  67 -1  N  TRP I  67   O  CYS I  72           
SHEET    3   W 6 GLY I 187  VAL I 189  1  O  VAL I 189   N  SER I  66           
SHEET    4   W 6 LEU I 172  ILE I 175 -1  N  CYS I 174   O  TYR I 188           
SHEET    5   W 6 ILE I 101  LEU I 103 -1  N  VAL I 102   O  ALA I 173           
SHEET    6   W 6 ASP I  80  TYR I  83 -1  N  TYR I  83   O  ILE I 101           
SHEET    1   X 3 GLN J 140  VAL J 141  0                                        
SHEET    2   X 3 ARG J 136  VAL J 137 -1  N  VAL J 137   O  GLN J 140           
SHEET    3   X 3 ILE J 157  ASP J 158 -1  O  ASP J 158   N  ARG J 136           
SHEET    1   Y 3 VAL K  20  VAL K  22  0                                        
SHEET    2   Y 3 TYR K  68  LEU K  71 -1  O  TRP K  69   N  MET K  21           
SHEET    3   Y 3 VAL K  58  GLN K  61 -1  N  GLN K  61   O  TYR K  68           
SHEET    1   Z 6 ILE L  68  LYS L  79  0                                        
SHEET    2   Z 6 THR L  85  LEU L  93 -1  O  ARG L  89   N  VAL L  76           
SHEET    3   Z 6 LYS L 104  HIS L 112 -1  O  LYS L 107   N  ARG L  90           
SHEET    4   Z 6 PHE L 140  VAL L 145  1  O  VAL L 142   N  HIS L 112           
SHEET    5   Z 6 ILE L 125  CYS L 131 -1  N  THR L 127   O  LYS L 144           
SHEET    6   Z 6 ILE L  68  LYS L  79 -1  N  GLY L  75   O  VAL L 126           
SHEET    1  AA 3 LEU M  31  ARG M  33  0                                        
SHEET    2  AA 3 VAL M 109  VAL M 111 -1  O  VAL M 110   N  ALA M  32           
SHEET    3  AA 3 CYS M  50  VAL M  51 -1  N  VAL M  51   O  VAL M 109           
SHEET    1  AB 5 ASP O  39  VAL O  42  0                                        
SHEET    2  AB 5 ILE O  33  SER O  36 -1  N  PHE O  34   O  PHE O  41           
SHEET    3  AB 5 ALA O  92  ARG O  98  1  O  ARG O  98   N  ALA O  35           
SHEET    4  AB 5 PHE O  28  VAL O  30  1  N  GLY O  29   O  HIS O  94           
SHEET    5  AB 5 THR O  45  ASP O  46 -1  O  THR O  45   N  VAL O  30           
SHEET    1  AC 4 ASP O  39  VAL O  42  0                                        
SHEET    2  AC 4 ILE O  33  SER O  36 -1  N  PHE O  34   O  PHE O  41           
SHEET    3  AC 4 ALA O  92  ARG O  98  1  O  ARG O  98   N  ALA O  35           
SHEET    4  AC 4 LYS O 125  ASP O 131  1  O  LYS O 125   N  LEU O  93           
SHEET    1  AD 3 VAL P  76  THR P  78  0                                        
SHEET    2  AD 3 MET P  93  TYR P  97  1  O  GLY P  95   N  VAL P  76           
SHEET    3  AD 3 PHE P 102  GLU P 106 -1  O  ASN P 103   N  VAL P  96           
SHEET    1  AE 5 SER Q   9  ARG Q  15  0                                        
SHEET    2  AE 5 THR Q  20  ARG Q  27 -1  O  ALA Q  23   N  VAL Q  12           
SHEET    3  AE 5 VAL Q  66  LYS Q  73 -1  O  ASP Q  67   N  LYS Q  26           
SHEET    4  AE 5 LYS Q  33  VAL Q  34  1  N  LYS Q  33   O  ILE Q  68           
SHEET    5  AE 5 ARG Q  37  PRO Q  38 -1  O  ARG Q  37   N  VAL Q  34           
SHEET    1  AF 2 LEU S  13  VAL S  15  0                                        
SHEET    2  AF 2 THR S  18  ILE S  20 -1  O  THR S  18   N  VAL S  15           
SHEET    1  AG 2 GLY T  81  GLN T  83  0                                        
SHEET    2  AG 2 HIS T  91  SER T  93 -1  O  HIS T  91   N  GLN T  83           
SHEET    1  AH 2 VAL T 113  LYS T 115  0                                        
SHEET    2  AH 2 ARG T 121  LEU T 123 -1  O  LYS T 122   N  GLU T 114           
SHEET    1  AI 4 VAL U  54  ARG U  66  0                                        
SHEET    2  AI 4 TRP U  77  SER U  93 -1  O  ILE U  84   N  LYS U  59           
SHEET    3  AI 4 HIS U  18  SER U  26 -1  N  ILE U  20   O  LEU U  91           
SHEET    4  AI 4 GLU U 111  THR U 115 -1  O  GLU U 113   N  THR U  23           
SHEET    1  AJ 2 GLN V   2  SER V   3  0                                        
SHEET    2  AJ 2 GLU V   7  PHE V   8 -1  O  GLU V   7   N  SER V   3           
SHEET    1  AK 2 ILE V  32  VAL V  39  0                                        
SHEET    2  AK 2 PHE V  46  ILE V  55 -1  O  LYS V  51   N  VAL V  36           
SHEET    1  AL 3 GLY W 109  ASP W 112  0                                        
SHEET    2  AL 3 PHE W 101  THR W 106 -1  N  LEU W 104   O  MET W 111           
SHEET    3  AL 3 GLY W 123  PHE W 129 -1  O  LYS W 124   N  THR W 105           
SHEET    1  AM 6 HIS X  46  VAL X  55  0                                        
SHEET    2  AM 6 CYS X  69  LEU X  74 -1  O  ARG X  71   N  LEU X  52           
SHEET    3  AM 6 LYS X  80  PHE X  84 -1  O  ILE X  81   N  VAL X  72           
SHEET    4  AM 6 PHE X 120  LYS X 124  1  O  PHE X 120   N  PHE X  84           
SHEET    5  AM 6 VAL X 100  GLY X 104 -1  N  LEU X 101   O  LYS X 124           
SHEET    6  AM 6 HIS X  46  VAL X  55 -1  N  ALA X  47   O  VAL X 102           
SHEET    1  AN 4 ILE Y   7  ASN Y  15  0                                        
SHEET    2  AN 4 ARG Y  20  LEU Y  28 -1  O  ASP Y  26   N  ARG Y   8           
SHEET    3  AN 4 LYS Y  68  TYR Y  76 -1  O  GLY Y  73   N  MET Y  23           
SHEET    4  AN 4 VAL Y  57  THR Y  62 -1  N  PHE Y  58   O  PHE Y  72           
SHEET    1  AO 3 LEU Z  67  ILE Z  68  0                                        
SHEET    2  AO 3 TYR Z 109  THR Z 110 -1  O  TYR Z 109   N  ILE Z  68           
SHEET    3  AO 3 LYS Z  98  LEU Z  99 -1  N  LYS Z  98   O  THR Z 110           
SHEET    1  AP 2 PRO a  20  ILE a  21  0                                        
SHEET    2  AP 2 VAL a  30  PRO a  31 -1  O  VAL a  30   N  ILE a  21           
SHEET    1  AQ 2 ILE a  36  ASN a  43  0                                        
SHEET    2  AQ 2 LYS a  66  TYR a  73 -1  O  LEU a  67   N  ARG a  42           
SHEET    1  AR 2 PHE b  32  VAL b  35  0                                        
SHEET    2  AR 2 THR b  44  PHE b  47 -1  O  VAL b  46   N  MET b  33           
SHEET    1  AS 4 SER c  41  VAL c  46  0                                        
SHEET    2  AS 4 CYS c  27  GLU c  33 -1  N  VAL c  32   O  ILE c  42           
SHEET    3  AS 4 LYS c  10  THR c  21 -1  N  THR c  15   O  ARG c  31           
SHEET    4  AS 4 VAL c  55  LEU c  58 -1  O  LEU c  56   N  ALA c  12           
SHEET    1  AT 2 LEU d  30  ILE d  31  0                                        
SHEET    2  AT 2 MET d  38  CYS d  39 -1  O  MET d  38   N  ILE d  31           
SHEET    1  AU 2 LYS f 107  VAL f 108  0                                        
SHEET    2  AU 2 ILE f 114  SER f 115 -1  O  SER f 115   N  LYS f 107           
SHEET    1  AV 3 MET f 132  SER f 134  0                                        
SHEET    2  AV 3 HIS f 139  CYS f 141 -1  O  TYR f 140   N  ALA f 133           
SHEET    3  AV 3 CYS f 149  PHE f 150 -1  O  PHE f 150   N  HIS f 139           
SHEET    1  AW 4 GLN g   4  LEU g  11  0                                        
SHEET    2  AW 4 VAL g 307  THR g 313 -1  O  THR g 313   N  GLN g   4           
SHEET    3  AW 4 THR g 297  TYR g 302 -1  N  LEU g 298   O  TRP g 310           
SHEET    4  AW 4 CYS g 286  TRP g 291 -1  N  ALA g 290   O  PHE g 299           
SHEET    1  AX 4 VAL g  18  ALA g  22  0                                        
SHEET    2  AX 4 MET g  30  SER g  35 -1  O  ALA g  34   N  GLN g  20           
SHEET    3  AX 4 ILE g  40  LEU g  45 -1  O  ILE g  41   N  SER g  33           
SHEET    4  AX 4 GLY g  53  ALA g  58 -1  O  GLN g  56   N  MET g  42           
SHEET    1  AY 4 VAL g  66  ILE g  71  0                                        
SHEET    2  AY 4 PHE g  77  SER g  82 -1  O  GLY g  81   N  ASP g  68           
SHEET    3  AY 4 LEU g  87  ASP g  91 -1  O  TRP g  90   N  ALA g  78           
SHEET    4  AY 4 GLY g  95  PHE g 101 -1  O  THR g  98   N  LEU g  89           
SHEET    1  AZ 4 VAL g 108  PHE g 113  0                                        
SHEET    2  AZ 4 ILE g 120  SER g 124 -1  O  GLY g 123   N  SER g 110           
SHEET    3  AZ 4 ILE g 129  TRP g 132 -1  O  TRP g 132   N  ILE g 120           
SHEET    4  AZ 4 CYS g 138  VAL g 142 -1  O  TYR g 140   N  LEU g 131           
SHEET    1  BA 4 VAL g 151  PHE g 156  0                                        
SHEET    2  BA 4 ILE g 164  GLY g 169 -1  O  VAL g 166   N  ARG g 155           
SHEET    3  BA 4 LEU g 173  ASN g 178 -1  O  TRP g 177   N  ILE g 165           
SHEET    4  BA 4 LYS g 183  ILE g 189 -1  O  HIS g 188   N  VAL g 174           
SHEET    1  BB 4 LEU g 195  VAL g 200  0                                        
SHEET    2  BB 4 LEU g 206  GLY g 211 -1  O  ALA g 208   N  THR g 199           
SHEET    3  BB 4 GLN g 215  ASP g 220 -1  O  MET g 217   N  SER g 209           
SHEET    4  BB 4 LYS g 225  ASP g 231 -1  O  LEU g 230   N  ALA g 216           
SHEET    1  BC 4 ILE g 236  PHE g 241  0                                        
SHEET    2  BC 4 TRP g 247  THR g 252 -1  O  ALA g 251   N  ASN g 237           
SHEET    3  BC 4 ILE g 256  ASP g 260 -1  O  TRP g 259   N  LEU g 248           
SHEET    4  BC 4 ILE g 265  LEU g 270 -1  O  LEU g 270   N  ILE g 256           
SSBOND   1 CYS a   26    CYS a   77                          1555   1555  2.81  
CISPEP   1 ALA D    2    VAL D    3          0        -4.01                     
CISPEP   2 GLY D  196    LYS D  197          0        -0.34                     
CISPEP   3 LYS D  197    ILE D  198          0         0.49                     
CISPEP   4 SER I  142    LYS I  143          0        -5.86                     
CISPEP   5 MET K    1    LEU K    2          0       -14.87                     
CISPEP   6 VAL N   22    PRO N   23          0         4.54                     
CISPEP   7 LEU R   91    ASP R   92          0         5.00                     
CISPEP   8 GLY V   77    ILE V   78          0        -0.21                     
CISPEP   9 ARG W   28    PRO W   29          0        18.50                     
CISPEP  10 SER W   76    PRO W   77          0         5.38                     
CISPEP  11 GLN X   61    PRO X   62          0        14.36                     
CISPEP  12 THR Y  102    SER Y  103          0       -27.61                     
CISPEP  13 ARG b   81    LYS b   82          0       -21.01                     
CISPEP  14 ASN e  118    VAL e  119          0        19.03                     
CISPEP  15 ASN f  111    GLY f  112          0        -6.44                     
CISPEP  16 GLU g  262    GLY g  263          0         0.87                     
CISPEP  17 SER g  278    SER g  279          0       -18.79                     
CRYST1  292.121  292.121  477.667  90.00  90.00 120.00 P 31 2 1      6          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.003423  0.001976  0.000000        0.00000                         
SCALE2      0.000000  0.003953  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.002094        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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