HEADER HYDROLASE 09-NOV-15 5ENY
TITLE KETOSYNTHASE FROM MODULE 6 CONNECTED TO ACYL CARRIER PROTEIN FROM
TITLE 2 MODULE 5 (UNOBSERVABLE) OF THE BACILLAENE SYNTHASE FROM BACILLUS
TITLE 3 SUBTILIS 168
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: POLYKETIDE SYNTHASE PKSL;
COMPND 3 CHAIN: A, B, C, D, E, F, G, H;
COMPND 4 SYNONYM: PKS;
COMPND 5 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;
SOURCE 3 ORGANISM_TAXID: 224308;
SOURCE 4 STRAIN: 168;
SOURCE 5 GENE: PKSL, OUTG, PKSA, PKSX, BSU17190;
SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS TRANS-AT KETOSYNTHASE, POLYKETIDE, BACILLAENE, HYDROLASE
EXPDTA X-RAY DIFFRACTION
AUTHOR D.T.WAGNER,D.C.GAY,A.T.KEATINGE-CLAY
REVDAT 2 02-NOV-16 5ENY 1 JRNL
REVDAT 1 23-DEC-15 5ENY 0
JRNL AUTH D.C.GAY,D.T.WAGNER,J.L.MEINKE,C.E.ZOGZAS,G.R.GAY,
JRNL AUTH 2 A.T.KEATINGE-CLAY
JRNL TITL THE LINKS MOTIF ZIPPERS TRANS-ACYLTRANSFERASE POLYKETIDE
JRNL TITL 2 SYNTHASE ASSEMBLY LINES INTO A BIOSYNTHETIC MEGACOMPLEX.
JRNL REF J.STRUCT.BIOL. V. 193 196 2016
JRNL REFN ESSN 1095-8657
JRNL PMID 26724270
JRNL DOI 10.1016/J.JSB.2015.12.011
REMARK 2
REMARK 2 RESOLUTION. 4.00 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : REFMAC 5.8.0107
REMARK 3 AUTHORS : MURSHUDOV,VAGIN,DODSON
REMARK 3
REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 4.00
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 39.77
REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL
REMARK 3 COMPLETENESS FOR RANGE (%) : 92.6
REMARK 3 NUMBER OF REFLECTIONS : NULL
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT
REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM
REMARK 3 R VALUE (WORKING + TEST SET) : 0.335
REMARK 3 R VALUE (WORKING SET) : 0.333
REMARK 3 FREE R VALUE : 0.354
REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.100
REMARK 3 FREE R VALUE TEST SET COUNT : 2126
REMARK 3
REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.
REMARK 3 TOTAL NUMBER OF BINS USED : 20
REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 4.00
REMARK 3 BIN RESOLUTION RANGE LOW (A) : 4.11
REMARK 3 REFLECTION IN BIN (WORKING SET) : 2247
REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 71.54
REMARK 3 BIN R VALUE (WORKING SET) : 0.3830
REMARK 3 BIN FREE R VALUE SET COUNT : 129
REMARK 3 BIN FREE R VALUE : 0.4240
REMARK 3
REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK 3 PROTEIN ATOMS : 34416
REMARK 3 NUCLEIC ACID ATOMS : 0
REMARK 3 HETEROGEN ATOMS : 0
REMARK 3 SOLVENT ATOMS : 0
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : NULL
REMARK 3 MEAN B VALUE (OVERALL, A**2) : 154.6
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : 0.21000
REMARK 3 B22 (A**2) : -0.18000
REMARK 3 B33 (A**2) : 0.01000
REMARK 3 B12 (A**2) : 0.03000
REMARK 3 B13 (A**2) : 0.02000
REMARK 3 B23 (A**2) : -0.05000
REMARK 3
REMARK 3 ESTIMATED OVERALL COORDINATE ERROR.
REMARK 3 ESU BASED ON R VALUE (A): NULL
REMARK 3 ESU BASED ON FREE R VALUE (A): 1.375
REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): NULL
REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): NULL
REMARK 3
REMARK 3 CORRELATION COEFFICIENTS.
REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.822
REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.797
REMARK 3
REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT
REMARK 3 BOND LENGTHS REFINED ATOMS (A): 35180 ; 0.006 ; 0.019
REMARK 3 BOND LENGTHS OTHERS (A): 33136 ; 0.000 ; 0.020
REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 47576 ; 0.852 ; 1.961
REMARK 3 BOND ANGLES OTHERS (DEGREES): 76484 ; 3.580 ; 3.000
REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 4340 ; 6.975 ; 5.000
REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 1612 ;35.727 ;24.491
REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 6020 ;15.181 ;15.000
REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 172 ;18.267 ;15.000
REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 5148 ; 0.068 ; 0.200
REMARK 3 GENERAL PLANES REFINED ATOMS (A): 39700 ; 0.006 ; 0.021
REMARK 3 GENERAL PLANES OTHERS (A): 7864 ; 0.005 ; 0.020
REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 NON-BONDED CONTACTS OTHERS (A): NULL ; NULL ; NULL
REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL
REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL
REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY VDW REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL
REMARK 3
REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT
REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 17492 ; 8.163 ;15.382
REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 17491 ; 8.163 ;15.382
REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 21788 ;12.030 ;23.045
REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): 21789 ;12.030 ;23.046
REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 17688 ; 7.476 ;15.856
REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): 17689 ; 7.476 ;15.856
REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): 25789 ;11.011 ;23.617
REMARK 3 LONG RANGE B REFINED ATOMS (A**2): 38919 ;17.930 ; NULL
REMARK 3 LONG RANGE B OTHER ATOMS (A**2): 38920 ;17.929 ; NULL
REMARK 3
REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT
REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL
REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3
REMARK 3 NCS RESTRAINTS STATISTICS
REMARK 3 NCS TYPE: LOCAL
REMARK 3 NUMBER OF DIFFERENT NCS PAIRS : 28
REMARK 3 GROUP CHAIN1 RANGE CHAIN2 RANGE COUNT RMS WEIGHT
REMARK 3 1 A 3 591 B 3 591 62986 0.15 0.05
REMARK 3 2 A 3 591 C 3 591 70278 0.12 0.05
REMARK 3 3 A 3 591 D 3 591 63036 0.16 0.05
REMARK 3 4 A 3 591 E 3 591 70022 0.13 0.05
REMARK 3 5 A 3 591 F 3 591 63078 0.16 0.05
REMARK 3 6 A 3 591 G 3 591 70000 0.12 0.05
REMARK 3 7 A 3 591 H 3 591 64286 0.12 0.05
REMARK 3 8 B 3 591 C 3 591 63092 0.15 0.05
REMARK 3 9 B 3 591 D 3 591 65998 0.11 0.05
REMARK 3 10 B 3 591 E 3 591 63410 0.15 0.05
REMARK 3 11 B 3 591 F 3 591 65558 0.12 0.05
REMARK 3 12 B 3 591 G 3 591 64070 0.12 0.05
REMARK 3 13 B 3 591 H 3 591 65436 0.13 0.05
REMARK 3 14 C 3 591 D 3 591 63354 0.15 0.05
REMARK 3 15 C 3 591 E 3 591 70316 0.12 0.05
REMARK 3 16 C 3 591 F 3 591 64062 0.13 0.05
REMARK 3 17 C 3 591 G 3 591 70126 0.12 0.05
REMARK 3 18 C 3 591 H 3 591 63256 0.15 0.05
REMARK 3 19 D 3 591 E 3 591 64242 0.12 0.05
REMARK 3 20 D 3 591 F 3 591 66052 0.12 0.05
REMARK 3 21 D 3 591 G 3 591 63466 0.15 0.05
REMARK 3 22 D 3 591 H 3 591 65646 0.13 0.05
REMARK 3 23 E 3 591 F 3 591 63304 0.15 0.05
REMARK 3 24 E 3 591 G 3 591 70890 0.10 0.05
REMARK 3 25 E 3 591 H 3 591 63306 0.16 0.05
REMARK 3 26 F 3 591 G 3 591 63034 0.15 0.05
REMARK 3 27 F 3 591 H 3 591 65602 0.12 0.05
REMARK 3 28 G 3 591 H 3 591 63276 0.16 0.05
REMARK 3
REMARK 3 TLS DETAILS
REMARK 3 NUMBER OF TLS GROUPS : NULL
REMARK 3
REMARK 3 BULK SOLVENT MODELLING.
REMARK 3 METHOD USED : MASK
REMARK 3 PARAMETERS FOR MASK CALCULATION
REMARK 3 VDW PROBE RADIUS : 1.20
REMARK 3 ION PROBE RADIUS : 0.80
REMARK 3 SHRINKAGE RADIUS : 0.80
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING
REMARK 3 POSITIONS
REMARK 4
REMARK 4 5ENY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 10-NOV-15.
REMARK 100 THE DEPOSITION ID IS D_1000215176.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : 10-NOV-13
REMARK 200 TEMPERATURE (KELVIN) : 100
REMARK 200 PH : NULL
REMARK 200 NUMBER OF CRYSTALS USED : NULL
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : Y
REMARK 200 RADIATION SOURCE : ALS
REMARK 200 BEAMLINE : 5.0.2
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M
REMARK 200 WAVELENGTH OR RANGE (A) : 1.0
REMARK 200 MONOCHROMATOR : NULL
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : CCD
REMARK 200 DETECTOR MANUFACTURER : ADSC QUANTUM 315R
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200 DATA SCALING SOFTWARE : HKL-2000
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 23712
REMARK 200 RESOLUTION RANGE HIGH (A) : 4.000
REMARK 200 RESOLUTION RANGE LOW (A) : 39.770
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : 98.7
REMARK 200 DATA REDUNDANCY : 3.300
REMARK 200 R MERGE (I) : NULL
REMARK 200 R SYM (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 6.1000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : NULL
REMARK 200 COMPLETENESS FOR SHELL (%) : NULL
REMARK 200 DATA REDUNDANCY IN SHELL : NULL
REMARK 200 R MERGE FOR SHELL (I) : NULL
REMARK 200 R SYM FOR SHELL (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR SHELL : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 39.26
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.02
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 25 MG/ML PKSACP5+KS6, 150 MM NACL, 10%
REMARK 280 GLYCEROL, 10 MM HEPES, PH 7.5) WITH 1 UL CRYSTALLIZATION BUFFER
REMARK 280 (30% PEG 4000 (V/V), 0.2 M SODIUM ACETATE, 0.1 M TRIS, PH 8.5,
REMARK 280 VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3640 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 42210 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -19.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3620 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 42050 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -19.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3610 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 42100 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -19.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3630 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 42090 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -19.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, H
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A -172
REMARK 465 GLY A -171
REMARK 465 SER A -170
REMARK 465 SER A -169
REMARK 465 HIS A -168
REMARK 465 HIS A -167
REMARK 465 HIS A -166
REMARK 465 HIS A -165
REMARK 465 HIS A -164
REMARK 465 HIS A -163
REMARK 465 SER A -162
REMARK 465 SER A -161
REMARK 465 GLY A -160
REMARK 465 LEU A -159
REMARK 465 VAL A -158
REMARK 465 PRO A -157
REMARK 465 ARG A -156
REMARK 465 GLY A -155
REMARK 465 SER A -154
REMARK 465 SER A -153
REMARK 465 ALA A -152
REMARK 465 GLU A -151
REMARK 465 GLU A -150
REMARK 465 THR A -149
REMARK 465 ILE A -148
REMARK 465 GLN A -147
REMARK 465 TYR A -146
REMARK 465 ALA A -145
REMARK 465 ALA A -144
REMARK 465 ALA A -143
REMARK 465 GLU A -142
REMARK 465 ILE A -141
REMARK 465 SER A -140
REMARK 465 ALA A -139
REMARK 465 SER A -138
REMARK 465 ARG A -137
REMARK 465 GLN A -136
REMARK 465 TYR A -135
REMARK 465 THR A -134
REMARK 465 VAL A -133
REMARK 465 ALA A -132
REMARK 465 ILE A -131
REMARK 465 GLU A -130
REMARK 465 THR A -129
REMARK 465 LEU A -128
REMARK 465 HIS A -127
REMARK 465 GLU A -126
REMARK 465 ASN A -125
REMARK 465 LEU A -124
REMARK 465 ARG A -123
REMARK 465 GLU A -122
REMARK 465 SER A -121
REMARK 465 ILE A -120
REMARK 465 ALA A -119
REMARK 465 ASP A -118
REMARK 465 VAL A -117
REMARK 465 LEU A -116
REMARK 465 TYR A -115
REMARK 465 MET A -114
REMARK 465 GLU A -113
REMARK 465 PRO A -112
REMARK 465 TYR A -111
REMARK 465 GLU A -110
REMARK 465 VAL A -109
REMARK 465 ASP A -108
REMARK 465 ILE A -107
REMARK 465 ASP A -106
REMARK 465 GLU A -105
REMARK 465 ALA A -104
REMARK 465 PHE A -103
REMARK 465 ILE A -102
REMARK 465 ASP A -101
REMARK 465 ILE A -100
REMARK 465 GLY A -99
REMARK 465 MET A -98
REMARK 465 ASP A -97
REMARK 465 SER A -96
REMARK 465 ILE A -95
REMARK 465 THR A -94
REMARK 465 GLY A -93
REMARK 465 LEU A -92
REMARK 465 GLU A -91
REMARK 465 TRP A -90
REMARK 465 ILE A -89
REMARK 465 LYS A -88
REMARK 465 ALA A -87
REMARK 465 VAL A -86
REMARK 465 ASN A -85
REMARK 465 LYS A -84
REMARK 465 GLN A -83
REMARK 465 TYR A -82
REMARK 465 GLY A -81
REMARK 465 THR A -80
REMARK 465 SER A -79
REMARK 465 PHE A -78
REMARK 465 THR A -77
REMARK 465 VAL A -76
REMARK 465 THR A -75
REMARK 465 ARG A -74
REMARK 465 VAL A -73
REMARK 465 TYR A -72
REMARK 465 ASP A -71
REMARK 465 TYR A -70
REMARK 465 PRO A -69
REMARK 465 THR A -68
REMARK 465 ILE A -67
REMARK 465 ARG A -66
REMARK 465 ASP A -65
REMARK 465 PHE A -64
REMARK 465 ALA A -63
REMARK 465 GLU A -62
REMARK 465 MET A -61
REMARK 465 LEU A -60
REMARK 465 LYS A -59
REMARK 465 SER A -58
REMARK 465 GLU A -57
REMARK 465 LEU A -56
REMARK 465 GLY A -55
REMARK 465 THR A -54
REMARK 465 HIS A -53
REMARK 465 LEU A -52
REMARK 465 ASP A -51
REMARK 465 ARG A -50
REMARK 465 LYS A -49
REMARK 465 ILE A -48
REMARK 465 GLU A -47
REMARK 465 HIS A -46
REMARK 465 THR A -45
REMARK 465 ASP A -44
REMARK 465 SER A -43
REMARK 465 PHE A -42
REMARK 465 GLU A -41
REMARK 465 ALA A -40
REMARK 465 ALA A -39
REMARK 465 GLN A -38
REMARK 465 GLN A -37
REMARK 465 LYS A -36
REMARK 465 PRO A -35
REMARK 465 ALA A -34
REMARK 465 ALA A -33
REMARK 465 SER A -32
REMARK 465 SER A -31
REMARK 465 HIS A -30
REMARK 465 PRO A -29
REMARK 465 LYS A -28
REMARK 465 PRO A -27
REMARK 465 ALA A -26
REMARK 465 GLU A -25
REMARK 465 ARG A -24
REMARK 465 PRO A -23
REMARK 465 LEU A -22
REMARK 465 GLN A -21
REMARK 465 PRO A -20
REMARK 465 VAL A -19
REMARK 465 GLN A -18
REMARK 465 HIS A -17
REMARK 465 PRO A -16
REMARK 465 ILE A -15
REMARK 465 LYS A -14
REMARK 465 LYS A -13
REMARK 465 GLU A -12
REMARK 465 HIS A -11
REMARK 465 GLU A -10
REMARK 465 LYS A -9
REMARK 465 LYS A -8
REMARK 465 THR A -7
REMARK 465 VAL A -6
REMARK 465 PRO A -5
REMARK 465 VAL A -4
REMARK 465 LEU A -3
REMARK 465 GLN A -2
REMARK 465 ASP A -1
REMARK 465 ARG A 0
REMARK 465 PRO A 1
REMARK 465 GLU A 2
REMARK 465 LEU A 52
REMARK 465 ASN A 53
REMARK 465 LYS A 54
REMARK 465 LYS A 55
REMARK 465 GLY A 56
REMARK 465 ARG A 134
REMARK 465 GLN A 135
REMARK 465 SER A 136
REMARK 465 ARG A 137
REMARK 465 ALA A 138
REMARK 465 ASN A 139
REMARK 465 ALA A 140
REMARK 465 THR A 141
REMARK 465 CYS A 209
REMARK 465 GLU A 210
REMARK 465 LYS A 428
REMARK 465 ARG A 429
REMARK 465 ASN A 430
REMARK 465 ASP A 431
REMARK 465 ARG A 432
REMARK 465 LEU A 433
REMARK 465 THR A 434
REMARK 465 LYS A 435
REMARK 465 GLN A 436
REMARK 465 HIS A 437
REMARK 465 ARG A 438
REMARK 465 MET B -172
REMARK 465 GLY B -171
REMARK 465 SER B -170
REMARK 465 SER B -169
REMARK 465 HIS B -168
REMARK 465 HIS B -167
REMARK 465 HIS B -166
REMARK 465 HIS B -165
REMARK 465 HIS B -164
REMARK 465 HIS B -163
REMARK 465 SER B -162
REMARK 465 SER B -161
REMARK 465 GLY B -160
REMARK 465 LEU B -159
REMARK 465 VAL B -158
REMARK 465 PRO B -157
REMARK 465 ARG B -156
REMARK 465 GLY B -155
REMARK 465 SER B -154
REMARK 465 SER B -153
REMARK 465 ALA B -152
REMARK 465 GLU B -151
REMARK 465 GLU B -150
REMARK 465 THR B -149
REMARK 465 ILE B -148
REMARK 465 GLN B -147
REMARK 465 TYR B -146
REMARK 465 ALA B -145
REMARK 465 ALA B -144
REMARK 465 ALA B -143
REMARK 465 GLU B -142
REMARK 465 ILE B -141
REMARK 465 SER B -140
REMARK 465 ALA B -139
REMARK 465 SER B -138
REMARK 465 ARG B -137
REMARK 465 GLN B -136
REMARK 465 TYR B -135
REMARK 465 THR B -134
REMARK 465 VAL B -133
REMARK 465 ALA B -132
REMARK 465 ILE B -131
REMARK 465 GLU B -130
REMARK 465 THR B -129
REMARK 465 LEU B -128
REMARK 465 HIS B -127
REMARK 465 GLU B -126
REMARK 465 ASN B -125
REMARK 465 LEU B -124
REMARK 465 ARG B -123
REMARK 465 GLU B -122
REMARK 465 SER B -121
REMARK 465 ILE B -120
REMARK 465 ALA B -119
REMARK 465 ASP B -118
REMARK 465 VAL B -117
REMARK 465 LEU B -116
REMARK 465 TYR B -115
REMARK 465 MET B -114
REMARK 465 GLU B -113
REMARK 465 PRO B -112
REMARK 465 TYR B -111
REMARK 465 GLU B -110
REMARK 465 VAL B -109
REMARK 465 ASP B -108
REMARK 465 ILE B -107
REMARK 465 ASP B -106
REMARK 465 GLU B -105
REMARK 465 ALA B -104
REMARK 465 PHE B -103
REMARK 465 ILE B -102
REMARK 465 ASP B -101
REMARK 465 ILE B -100
REMARK 465 GLY B -99
REMARK 465 MET B -98
REMARK 465 ASP B -97
REMARK 465 SER B -96
REMARK 465 ILE B -95
REMARK 465 THR B -94
REMARK 465 GLY B -93
REMARK 465 LEU B -92
REMARK 465 GLU B -91
REMARK 465 TRP B -90
REMARK 465 ILE B -89
REMARK 465 LYS B -88
REMARK 465 ALA B -87
REMARK 465 VAL B -86
REMARK 465 ASN B -85
REMARK 465 LYS B -84
REMARK 465 GLN B -83
REMARK 465 TYR B -82
REMARK 465 GLY B -81
REMARK 465 THR B -80
REMARK 465 SER B -79
REMARK 465 PHE B -78
REMARK 465 THR B -77
REMARK 465 VAL B -76
REMARK 465 THR B -75
REMARK 465 ARG B -74
REMARK 465 VAL B -73
REMARK 465 TYR B -72
REMARK 465 ASP B -71
REMARK 465 TYR B -70
REMARK 465 PRO B -69
REMARK 465 THR B -68
REMARK 465 ILE B -67
REMARK 465 ARG B -66
REMARK 465 ASP B -65
REMARK 465 PHE B -64
REMARK 465 ALA B -63
REMARK 465 GLU B -62
REMARK 465 MET B -61
REMARK 465 LEU B -60
REMARK 465 LYS B -59
REMARK 465 SER B -58
REMARK 465 GLU B -57
REMARK 465 LEU B -56
REMARK 465 GLY B -55
REMARK 465 THR B -54
REMARK 465 HIS B -53
REMARK 465 LEU B -52
REMARK 465 ASP B -51
REMARK 465 ARG B -50
REMARK 465 LYS B -49
REMARK 465 ILE B -48
REMARK 465 GLU B -47
REMARK 465 HIS B -46
REMARK 465 THR B -45
REMARK 465 ASP B -44
REMARK 465 SER B -43
REMARK 465 PHE B -42
REMARK 465 GLU B -41
REMARK 465 ALA B -40
REMARK 465 ALA B -39
REMARK 465 GLN B -38
REMARK 465 GLN B -37
REMARK 465 LYS B -36
REMARK 465 PRO B -35
REMARK 465 ALA B -34
REMARK 465 ALA B -33
REMARK 465 SER B -32
REMARK 465 SER B -31
REMARK 465 HIS B -30
REMARK 465 PRO B -29
REMARK 465 LYS B -28
REMARK 465 PRO B -27
REMARK 465 ALA B -26
REMARK 465 GLU B -25
REMARK 465 ARG B -24
REMARK 465 PRO B -23
REMARK 465 LEU B -22
REMARK 465 GLN B -21
REMARK 465 PRO B -20
REMARK 465 VAL B -19
REMARK 465 GLN B -18
REMARK 465 HIS B -17
REMARK 465 PRO B -16
REMARK 465 ILE B -15
REMARK 465 LYS B -14
REMARK 465 LYS B -13
REMARK 465 GLU B -12
REMARK 465 HIS B -11
REMARK 465 GLU B -10
REMARK 465 LYS B -9
REMARK 465 LYS B -8
REMARK 465 THR B -7
REMARK 465 VAL B -6
REMARK 465 PRO B -5
REMARK 465 VAL B -4
REMARK 465 LEU B -3
REMARK 465 GLN B -2
REMARK 465 ASP B -1
REMARK 465 ARG B 0
REMARK 465 PRO B 1
REMARK 465 GLU B 2
REMARK 465 ASP B 45
REMARK 465 LYS B 46
REMARK 465 TYR B 47
REMARK 465 TYR B 48
REMARK 465 ASP B 49
REMARK 465 PRO B 50
REMARK 465 VAL B 51
REMARK 465 LEU B 52
REMARK 465 ASN B 53
REMARK 465 LYS B 54
REMARK 465 LYS B 55
REMARK 465 GLY B 56
REMARK 465 LYS B 57
REMARK 465 VAL B 58
REMARK 465 TYR B 59
REMARK 465 ASN B 133
REMARK 465 ARG B 134
REMARK 465 GLN B 135
REMARK 465 SER B 136
REMARK 465 ARG B 137
REMARK 465 ALA B 138
REMARK 465 ASN B 139
REMARK 465 ALA B 140
REMARK 465 THR B 141
REMARK 465 MET B 206
REMARK 465 SER B 207
REMARK 465 MET B 208
REMARK 465 CYS B 209
REMARK 465 GLU B 210
REMARK 465 ALA B 211
REMARK 465 GLY B 212
REMARK 465 MET B 213
REMARK 465 LEU B 214
REMARK 465 SER B 215
REMARK 465 PRO B 216
REMARK 465 ASP B 217
REMARK 465 GLY B 218
REMARK 465 GLN B 219
REMARK 465 CYS B 220
REMARK 465 LYS B 221
REMARK 465 ALA B 222
REMARK 465 PHE B 223
REMARK 465 ASP B 224
REMARK 465 ASN B 225
REMARK 465 LYS B 309
REMARK 465 GLN B 310
REMARK 465 LYS B 428
REMARK 465 ARG B 429
REMARK 465 ASN B 430
REMARK 465 ASP B 431
REMARK 465 ARG B 432
REMARK 465 LEU B 433
REMARK 465 THR B 434
REMARK 465 LYS B 435
REMARK 465 GLN B 436
REMARK 465 HIS B 437
REMARK 465 MET C -172
REMARK 465 GLY C -171
REMARK 465 SER C -170
REMARK 465 SER C -169
REMARK 465 HIS C -168
REMARK 465 HIS C -167
REMARK 465 HIS C -166
REMARK 465 HIS C -165
REMARK 465 HIS C -164
REMARK 465 HIS C -163
REMARK 465 SER C -162
REMARK 465 SER C -161
REMARK 465 GLY C -160
REMARK 465 LEU C -159
REMARK 465 VAL C -158
REMARK 465 PRO C -157
REMARK 465 ARG C -156
REMARK 465 GLY C -155
REMARK 465 SER C -154
REMARK 465 SER C -153
REMARK 465 ALA C -152
REMARK 465 GLU C -151
REMARK 465 GLU C -150
REMARK 465 THR C -149
REMARK 465 ILE C -148
REMARK 465 GLN C -147
REMARK 465 TYR C -146
REMARK 465 ALA C -145
REMARK 465 ALA C -144
REMARK 465 ALA C -143
REMARK 465 GLU C -142
REMARK 465 ILE C -141
REMARK 465 SER C -140
REMARK 465 ALA C -139
REMARK 465 SER C -138
REMARK 465 ARG C -137
REMARK 465 GLN C -136
REMARK 465 TYR C -135
REMARK 465 THR C -134
REMARK 465 VAL C -133
REMARK 465 ALA C -132
REMARK 465 ILE C -131
REMARK 465 GLU C -130
REMARK 465 THR C -129
REMARK 465 LEU C -128
REMARK 465 HIS C -127
REMARK 465 GLU C -126
REMARK 465 ASN C -125
REMARK 465 LEU C -124
REMARK 465 ARG C -123
REMARK 465 GLU C -122
REMARK 465 SER C -121
REMARK 465 ILE C -120
REMARK 465 ALA C -119
REMARK 465 ASP C -118
REMARK 465 VAL C -117
REMARK 465 LEU C -116
REMARK 465 TYR C -115
REMARK 465 MET C -114
REMARK 465 GLU C -113
REMARK 465 PRO C -112
REMARK 465 TYR C -111
REMARK 465 GLU C -110
REMARK 465 VAL C -109
REMARK 465 ASP C -108
REMARK 465 ILE C -107
REMARK 465 ASP C -106
REMARK 465 GLU C -105
REMARK 465 ALA C -104
REMARK 465 PHE C -103
REMARK 465 ILE C -102
REMARK 465 ASP C -101
REMARK 465 ILE C -100
REMARK 465 GLY C -99
REMARK 465 MET C -98
REMARK 465 ASP C -97
REMARK 465 SER C -96
REMARK 465 ILE C -95
REMARK 465 THR C -94
REMARK 465 GLY C -93
REMARK 465 LEU C -92
REMARK 465 GLU C -91
REMARK 465 TRP C -90
REMARK 465 ILE C -89
REMARK 465 LYS C -88
REMARK 465 ALA C -87
REMARK 465 VAL C -86
REMARK 465 ASN C -85
REMARK 465 LYS C -84
REMARK 465 GLN C -83
REMARK 465 TYR C -82
REMARK 465 GLY C -81
REMARK 465 THR C -80
REMARK 465 SER C -79
REMARK 465 PHE C -78
REMARK 465 THR C -77
REMARK 465 VAL C -76
REMARK 465 THR C -75
REMARK 465 ARG C -74
REMARK 465 VAL C -73
REMARK 465 TYR C -72
REMARK 465 ASP C -71
REMARK 465 TYR C -70
REMARK 465 PRO C -69
REMARK 465 THR C -68
REMARK 465 ILE C -67
REMARK 465 ARG C -66
REMARK 465 ASP C -65
REMARK 465 PHE C -64
REMARK 465 ALA C -63
REMARK 465 GLU C -62
REMARK 465 MET C -61
REMARK 465 LEU C -60
REMARK 465 LYS C -59
REMARK 465 SER C -58
REMARK 465 GLU C -57
REMARK 465 LEU C -56
REMARK 465 GLY C -55
REMARK 465 THR C -54
REMARK 465 HIS C -53
REMARK 465 LEU C -52
REMARK 465 ASP C -51
REMARK 465 ARG C -50
REMARK 465 LYS C -49
REMARK 465 ILE C -48
REMARK 465 GLU C -47
REMARK 465 HIS C -46
REMARK 465 THR C -45
REMARK 465 ASP C -44
REMARK 465 SER C -43
REMARK 465 PHE C -42
REMARK 465 GLU C -41
REMARK 465 ALA C -40
REMARK 465 ALA C -39
REMARK 465 GLN C -38
REMARK 465 GLN C -37
REMARK 465 LYS C -36
REMARK 465 PRO C -35
REMARK 465 ALA C -34
REMARK 465 ALA C -33
REMARK 465 SER C -32
REMARK 465 SER C -31
REMARK 465 HIS C -30
REMARK 465 PRO C -29
REMARK 465 LYS C -28
REMARK 465 PRO C -27
REMARK 465 ALA C -26
REMARK 465 GLU C -25
REMARK 465 ARG C -24
REMARK 465 PRO C -23
REMARK 465 LEU C -22
REMARK 465 GLN C -21
REMARK 465 PRO C -20
REMARK 465 VAL C -19
REMARK 465 GLN C -18
REMARK 465 HIS C -17
REMARK 465 PRO C -16
REMARK 465 ILE C -15
REMARK 465 LYS C -14
REMARK 465 LYS C -13
REMARK 465 GLU C -12
REMARK 465 HIS C -11
REMARK 465 GLU C -10
REMARK 465 LYS C -9
REMARK 465 LYS C -8
REMARK 465 THR C -7
REMARK 465 VAL C -6
REMARK 465 PRO C -5
REMARK 465 VAL C -4
REMARK 465 LEU C -3
REMARK 465 GLN C -2
REMARK 465 ASP C -1
REMARK 465 ARG C 0
REMARK 465 PRO C 1
REMARK 465 GLU C 2
REMARK 465 LEU C 52
REMARK 465 ASN C 53
REMARK 465 LYS C 54
REMARK 465 LYS C 55
REMARK 465 GLY C 56
REMARK 465 ARG C 134
REMARK 465 GLN C 135
REMARK 465 SER C 136
REMARK 465 ARG C 137
REMARK 465 ALA C 138
REMARK 465 ASN C 139
REMARK 465 ALA C 140
REMARK 465 THR C 141
REMARK 465 CYS C 209
REMARK 465 GLU C 210
REMARK 465 LYS C 428
REMARK 465 ARG C 429
REMARK 465 ASN C 430
REMARK 465 ASP C 431
REMARK 465 ARG C 432
REMARK 465 LEU C 433
REMARK 465 THR C 434
REMARK 465 LYS C 435
REMARK 465 GLN C 436
REMARK 465 HIS C 437
REMARK 465 ARG C 438
REMARK 465 MET D -172
REMARK 465 GLY D -171
REMARK 465 SER D -170
REMARK 465 SER D -169
REMARK 465 HIS D -168
REMARK 465 HIS D -167
REMARK 465 HIS D -166
REMARK 465 HIS D -165
REMARK 465 HIS D -164
REMARK 465 HIS D -163
REMARK 465 SER D -162
REMARK 465 SER D -161
REMARK 465 GLY D -160
REMARK 465 LEU D -159
REMARK 465 VAL D -158
REMARK 465 PRO D -157
REMARK 465 ARG D -156
REMARK 465 GLY D -155
REMARK 465 SER D -154
REMARK 465 SER D -153
REMARK 465 ALA D -152
REMARK 465 GLU D -151
REMARK 465 GLU D -150
REMARK 465 THR D -149
REMARK 465 ILE D -148
REMARK 465 GLN D -147
REMARK 465 TYR D -146
REMARK 465 ALA D -145
REMARK 465 ALA D -144
REMARK 465 ALA D -143
REMARK 465 GLU D -142
REMARK 465 ILE D -141
REMARK 465 SER D -140
REMARK 465 ALA D -139
REMARK 465 SER D -138
REMARK 465 ARG D -137
REMARK 465 GLN D -136
REMARK 465 TYR D -135
REMARK 465 THR D -134
REMARK 465 VAL D -133
REMARK 465 ALA D -132
REMARK 465 ILE D -131
REMARK 465 GLU D -130
REMARK 465 THR D -129
REMARK 465 LEU D -128
REMARK 465 HIS D -127
REMARK 465 GLU D -126
REMARK 465 ASN D -125
REMARK 465 LEU D -124
REMARK 465 ARG D -123
REMARK 465 GLU D -122
REMARK 465 SER D -121
REMARK 465 ILE D -120
REMARK 465 ALA D -119
REMARK 465 ASP D -118
REMARK 465 VAL D -117
REMARK 465 LEU D -116
REMARK 465 TYR D -115
REMARK 465 MET D -114
REMARK 465 GLU D -113
REMARK 465 PRO D -112
REMARK 465 TYR D -111
REMARK 465 GLU D -110
REMARK 465 VAL D -109
REMARK 465 ASP D -108
REMARK 465 ILE D -107
REMARK 465 ASP D -106
REMARK 465 GLU D -105
REMARK 465 ALA D -104
REMARK 465 PHE D -103
REMARK 465 ILE D -102
REMARK 465 ASP D -101
REMARK 465 ILE D -100
REMARK 465 GLY D -99
REMARK 465 MET D -98
REMARK 465 ASP D -97
REMARK 465 SER D -96
REMARK 465 ILE D -95
REMARK 465 THR D -94
REMARK 465 GLY D -93
REMARK 465 LEU D -92
REMARK 465 GLU D -91
REMARK 465 TRP D -90
REMARK 465 ILE D -89
REMARK 465 LYS D -88
REMARK 465 ALA D -87
REMARK 465 VAL D -86
REMARK 465 ASN D -85
REMARK 465 LYS D -84
REMARK 465 GLN D -83
REMARK 465 TYR D -82
REMARK 465 GLY D -81
REMARK 465 THR D -80
REMARK 465 SER D -79
REMARK 465 PHE D -78
REMARK 465 THR D -77
REMARK 465 VAL D -76
REMARK 465 THR D -75
REMARK 465 ARG D -74
REMARK 465 VAL D -73
REMARK 465 TYR D -72
REMARK 465 ASP D -71
REMARK 465 TYR D -70
REMARK 465 PRO D -69
REMARK 465 THR D -68
REMARK 465 ILE D -67
REMARK 465 ARG D -66
REMARK 465 ASP D -65
REMARK 465 PHE D -64
REMARK 465 ALA D -63
REMARK 465 GLU D -62
REMARK 465 MET D -61
REMARK 465 LEU D -60
REMARK 465 LYS D -59
REMARK 465 SER D -58
REMARK 465 GLU D -57
REMARK 465 LEU D -56
REMARK 465 GLY D -55
REMARK 465 THR D -54
REMARK 465 HIS D -53
REMARK 465 LEU D -52
REMARK 465 ASP D -51
REMARK 465 ARG D -50
REMARK 465 LYS D -49
REMARK 465 ILE D -48
REMARK 465 GLU D -47
REMARK 465 HIS D -46
REMARK 465 THR D -45
REMARK 465 ASP D -44
REMARK 465 SER D -43
REMARK 465 PHE D -42
REMARK 465 GLU D -41
REMARK 465 ALA D -40
REMARK 465 ALA D -39
REMARK 465 GLN D -38
REMARK 465 GLN D -37
REMARK 465 LYS D -36
REMARK 465 PRO D -35
REMARK 465 ALA D -34
REMARK 465 ALA D -33
REMARK 465 SER D -32
REMARK 465 SER D -31
REMARK 465 HIS D -30
REMARK 465 PRO D -29
REMARK 465 LYS D -28
REMARK 465 PRO D -27
REMARK 465 ALA D -26
REMARK 465 GLU D -25
REMARK 465 ARG D -24
REMARK 465 PRO D -23
REMARK 465 LEU D -22
REMARK 465 GLN D -21
REMARK 465 PRO D -20
REMARK 465 VAL D -19
REMARK 465 GLN D -18
REMARK 465 HIS D -17
REMARK 465 PRO D -16
REMARK 465 ILE D -15
REMARK 465 LYS D -14
REMARK 465 LYS D -13
REMARK 465 GLU D -12
REMARK 465 HIS D -11
REMARK 465 GLU D -10
REMARK 465 LYS D -9
REMARK 465 LYS D -8
REMARK 465 THR D -7
REMARK 465 VAL D -6
REMARK 465 PRO D -5
REMARK 465 VAL D -4
REMARK 465 LEU D -3
REMARK 465 GLN D -2
REMARK 465 ASP D -1
REMARK 465 ARG D 0
REMARK 465 PRO D 1
REMARK 465 GLU D 2
REMARK 465 ASP D 45
REMARK 465 LYS D 46
REMARK 465 TYR D 47
REMARK 465 TYR D 48
REMARK 465 ASP D 49
REMARK 465 PRO D 50
REMARK 465 VAL D 51
REMARK 465 LEU D 52
REMARK 465 ASN D 53
REMARK 465 LYS D 54
REMARK 465 LYS D 55
REMARK 465 GLY D 56
REMARK 465 LYS D 57
REMARK 465 VAL D 58
REMARK 465 TYR D 59
REMARK 465 ASN D 133
REMARK 465 ARG D 134
REMARK 465 GLN D 135
REMARK 465 SER D 136
REMARK 465 ARG D 137
REMARK 465 ALA D 138
REMARK 465 ASN D 139
REMARK 465 ALA D 140
REMARK 465 THR D 141
REMARK 465 MET D 206
REMARK 465 SER D 207
REMARK 465 MET D 208
REMARK 465 CYS D 209
REMARK 465 GLU D 210
REMARK 465 ALA D 211
REMARK 465 GLY D 212
REMARK 465 MET D 213
REMARK 465 LEU D 214
REMARK 465 SER D 215
REMARK 465 PRO D 216
REMARK 465 ASP D 217
REMARK 465 GLY D 218
REMARK 465 GLN D 219
REMARK 465 CYS D 220
REMARK 465 LYS D 221
REMARK 465 ALA D 222
REMARK 465 PHE D 223
REMARK 465 ASP D 224
REMARK 465 ASN D 225
REMARK 465 LYS D 309
REMARK 465 GLN D 310
REMARK 465 LYS D 428
REMARK 465 ARG D 429
REMARK 465 ASN D 430
REMARK 465 ASP D 431
REMARK 465 ARG D 432
REMARK 465 LEU D 433
REMARK 465 THR D 434
REMARK 465 LYS D 435
REMARK 465 GLN D 436
REMARK 465 HIS D 437
REMARK 465 MET E -172
REMARK 465 GLY E -171
REMARK 465 SER E -170
REMARK 465 SER E -169
REMARK 465 HIS E -168
REMARK 465 HIS E -167
REMARK 465 HIS E -166
REMARK 465 HIS E -165
REMARK 465 HIS E -164
REMARK 465 HIS E -163
REMARK 465 SER E -162
REMARK 465 SER E -161
REMARK 465 GLY E -160
REMARK 465 LEU E -159
REMARK 465 VAL E -158
REMARK 465 PRO E -157
REMARK 465 ARG E -156
REMARK 465 GLY E -155
REMARK 465 SER E -154
REMARK 465 SER E -153
REMARK 465 ALA E -152
REMARK 465 GLU E -151
REMARK 465 GLU E -150
REMARK 465 THR E -149
REMARK 465 ILE E -148
REMARK 465 GLN E -147
REMARK 465 TYR E -146
REMARK 465 ALA E -145
REMARK 465 ALA E -144
REMARK 465 ALA E -143
REMARK 465 GLU E -142
REMARK 465 ILE E -141
REMARK 465 SER E -140
REMARK 465 ALA E -139
REMARK 465 SER E -138
REMARK 465 ARG E -137
REMARK 465 GLN E -136
REMARK 465 TYR E -135
REMARK 465 THR E -134
REMARK 465 VAL E -133
REMARK 465 ALA E -132
REMARK 465 ILE E -131
REMARK 465 GLU E -130
REMARK 465 THR E -129
REMARK 465 LEU E -128
REMARK 465 HIS E -127
REMARK 465 GLU E -126
REMARK 465 ASN E -125
REMARK 465 LEU E -124
REMARK 465 ARG E -123
REMARK 465 GLU E -122
REMARK 465 SER E -121
REMARK 465 ILE E -120
REMARK 465 ALA E -119
REMARK 465 ASP E -118
REMARK 465 VAL E -117
REMARK 465 LEU E -116
REMARK 465 TYR E -115
REMARK 465 MET E -114
REMARK 465 GLU E -113
REMARK 465 PRO E -112
REMARK 465 TYR E -111
REMARK 465 GLU E -110
REMARK 465 VAL E -109
REMARK 465 ASP E -108
REMARK 465 ILE E -107
REMARK 465 ASP E -106
REMARK 465 GLU E -105
REMARK 465 ALA E -104
REMARK 465 PHE E -103
REMARK 465 ILE E -102
REMARK 465 ASP E -101
REMARK 465 ILE E -100
REMARK 465 GLY E -99
REMARK 465 MET E -98
REMARK 465 ASP E -97
REMARK 465 SER E -96
REMARK 465 ILE E -95
REMARK 465 THR E -94
REMARK 465 GLY E -93
REMARK 465 LEU E -92
REMARK 465 GLU E -91
REMARK 465 TRP E -90
REMARK 465 ILE E -89
REMARK 465 LYS E -88
REMARK 465 ALA E -87
REMARK 465 VAL E -86
REMARK 465 ASN E -85
REMARK 465 LYS E -84
REMARK 465 GLN E -83
REMARK 465 TYR E -82
REMARK 465 GLY E -81
REMARK 465 THR E -80
REMARK 465 SER E -79
REMARK 465 PHE E -78
REMARK 465 THR E -77
REMARK 465 VAL E -76
REMARK 465 THR E -75
REMARK 465 ARG E -74
REMARK 465 VAL E -73
REMARK 465 TYR E -72
REMARK 465 ASP E -71
REMARK 465 TYR E -70
REMARK 465 PRO E -69
REMARK 465 THR E -68
REMARK 465 ILE E -67
REMARK 465 ARG E -66
REMARK 465 ASP E -65
REMARK 465 PHE E -64
REMARK 465 ALA E -63
REMARK 465 GLU E -62
REMARK 465 MET E -61
REMARK 465 LEU E -60
REMARK 465 LYS E -59
REMARK 465 SER E -58
REMARK 465 GLU E -57
REMARK 465 LEU E -56
REMARK 465 GLY E -55
REMARK 465 THR E -54
REMARK 465 HIS E -53
REMARK 465 LEU E -52
REMARK 465 ASP E -51
REMARK 465 ARG E -50
REMARK 465 LYS E -49
REMARK 465 ILE E -48
REMARK 465 GLU E -47
REMARK 465 HIS E -46
REMARK 465 THR E -45
REMARK 465 ASP E -44
REMARK 465 SER E -43
REMARK 465 PHE E -42
REMARK 465 GLU E -41
REMARK 465 ALA E -40
REMARK 465 ALA E -39
REMARK 465 GLN E -38
REMARK 465 GLN E -37
REMARK 465 LYS E -36
REMARK 465 PRO E -35
REMARK 465 ALA E -34
REMARK 465 ALA E -33
REMARK 465 SER E -32
REMARK 465 SER E -31
REMARK 465 HIS E -30
REMARK 465 PRO E -29
REMARK 465 LYS E -28
REMARK 465 PRO E -27
REMARK 465 ALA E -26
REMARK 465 GLU E -25
REMARK 465 ARG E -24
REMARK 465 PRO E -23
REMARK 465 LEU E -22
REMARK 465 GLN E -21
REMARK 465 PRO E -20
REMARK 465 VAL E -19
REMARK 465 GLN E -18
REMARK 465 HIS E -17
REMARK 465 PRO E -16
REMARK 465 ILE E -15
REMARK 465 LYS E -14
REMARK 465 LYS E -13
REMARK 465 GLU E -12
REMARK 465 HIS E -11
REMARK 465 GLU E -10
REMARK 465 LYS E -9
REMARK 465 LYS E -8
REMARK 465 THR E -7
REMARK 465 VAL E -6
REMARK 465 PRO E -5
REMARK 465 VAL E -4
REMARK 465 LEU E -3
REMARK 465 GLN E -2
REMARK 465 ASP E -1
REMARK 465 ARG E 0
REMARK 465 PRO E 1
REMARK 465 GLU E 2
REMARK 465 LEU E 52
REMARK 465 ASN E 53
REMARK 465 LYS E 54
REMARK 465 LYS E 55
REMARK 465 GLY E 56
REMARK 465 ARG E 134
REMARK 465 GLN E 135
REMARK 465 SER E 136
REMARK 465 ARG E 137
REMARK 465 ALA E 138
REMARK 465 ASN E 139
REMARK 465 ALA E 140
REMARK 465 THR E 141
REMARK 465 CYS E 209
REMARK 465 GLU E 210
REMARK 465 LYS E 428
REMARK 465 ARG E 429
REMARK 465 ASN E 430
REMARK 465 ASP E 431
REMARK 465 ARG E 432
REMARK 465 LEU E 433
REMARK 465 THR E 434
REMARK 465 LYS E 435
REMARK 465 GLN E 436
REMARK 465 HIS E 437
REMARK 465 ARG E 438
REMARK 465 MET F -172
REMARK 465 GLY F -171
REMARK 465 SER F -170
REMARK 465 SER F -169
REMARK 465 HIS F -168
REMARK 465 HIS F -167
REMARK 465 HIS F -166
REMARK 465 HIS F -165
REMARK 465 HIS F -164
REMARK 465 HIS F -163
REMARK 465 SER F -162
REMARK 465 SER F -161
REMARK 465 GLY F -160
REMARK 465 LEU F -159
REMARK 465 VAL F -158
REMARK 465 PRO F -157
REMARK 465 ARG F -156
REMARK 465 GLY F -155
REMARK 465 SER F -154
REMARK 465 SER F -153
REMARK 465 ALA F -152
REMARK 465 GLU F -151
REMARK 465 GLU F -150
REMARK 465 THR F -149
REMARK 465 ILE F -148
REMARK 465 GLN F -147
REMARK 465 TYR F -146
REMARK 465 ALA F -145
REMARK 465 ALA F -144
REMARK 465 ALA F -143
REMARK 465 GLU F -142
REMARK 465 ILE F -141
REMARK 465 SER F -140
REMARK 465 ALA F -139
REMARK 465 SER F -138
REMARK 465 ARG F -137
REMARK 465 GLN F -136
REMARK 465 TYR F -135
REMARK 465 THR F -134
REMARK 465 VAL F -133
REMARK 465 ALA F -132
REMARK 465 ILE F -131
REMARK 465 GLU F -130
REMARK 465 THR F -129
REMARK 465 LEU F -128
REMARK 465 HIS F -127
REMARK 465 GLU F -126
REMARK 465 ASN F -125
REMARK 465 LEU F -124
REMARK 465 ARG F -123
REMARK 465 GLU F -122
REMARK 465 SER F -121
REMARK 465 ILE F -120
REMARK 465 ALA F -119
REMARK 465 ASP F -118
REMARK 465 VAL F -117
REMARK 465 LEU F -116
REMARK 465 TYR F -115
REMARK 465 MET F -114
REMARK 465 GLU F -113
REMARK 465 PRO F -112
REMARK 465 TYR F -111
REMARK 465 GLU F -110
REMARK 465 VAL F -109
REMARK 465 ASP F -108
REMARK 465 ILE F -107
REMARK 465 ASP F -106
REMARK 465 GLU F -105
REMARK 465 ALA F -104
REMARK 465 PHE F -103
REMARK 465 ILE F -102
REMARK 465 ASP F -101
REMARK 465 ILE F -100
REMARK 465 GLY F -99
REMARK 465 MET F -98
REMARK 465 ASP F -97
REMARK 465 SER F -96
REMARK 465 ILE F -95
REMARK 465 THR F -94
REMARK 465 GLY F -93
REMARK 465 LEU F -92
REMARK 465 GLU F -91
REMARK 465 TRP F -90
REMARK 465 ILE F -89
REMARK 465 LYS F -88
REMARK 465 ALA F -87
REMARK 465 VAL F -86
REMARK 465 ASN F -85
REMARK 465 LYS F -84
REMARK 465 GLN F -83
REMARK 465 TYR F -82
REMARK 465 GLY F -81
REMARK 465 THR F -80
REMARK 465 SER F -79
REMARK 465 PHE F -78
REMARK 465 THR F -77
REMARK 465 VAL F -76
REMARK 465 THR F -75
REMARK 465 ARG F -74
REMARK 465 VAL F -73
REMARK 465 TYR F -72
REMARK 465 ASP F -71
REMARK 465 TYR F -70
REMARK 465 PRO F -69
REMARK 465 THR F -68
REMARK 465 ILE F -67
REMARK 465 ARG F -66
REMARK 465 ASP F -65
REMARK 465 PHE F -64
REMARK 465 ALA F -63
REMARK 465 GLU F -62
REMARK 465 MET F -61
REMARK 465 LEU F -60
REMARK 465 LYS F -59
REMARK 465 SER F -58
REMARK 465 GLU F -57
REMARK 465 LEU F -56
REMARK 465 GLY F -55
REMARK 465 THR F -54
REMARK 465 HIS F -53
REMARK 465 LEU F -52
REMARK 465 ASP F -51
REMARK 465 ARG F -50
REMARK 465 LYS F -49
REMARK 465 ILE F -48
REMARK 465 GLU F -47
REMARK 465 HIS F -46
REMARK 465 THR F -45
REMARK 465 ASP F -44
REMARK 465 SER F -43
REMARK 465 PHE F -42
REMARK 465 GLU F -41
REMARK 465 ALA F -40
REMARK 465 ALA F -39
REMARK 465 GLN F -38
REMARK 465 GLN F -37
REMARK 465 LYS F -36
REMARK 465 PRO F -35
REMARK 465 ALA F -34
REMARK 465 ALA F -33
REMARK 465 SER F -32
REMARK 465 SER F -31
REMARK 465 HIS F -30
REMARK 465 PRO F -29
REMARK 465 LYS F -28
REMARK 465 PRO F -27
REMARK 465 ALA F -26
REMARK 465 GLU F -25
REMARK 465 ARG F -24
REMARK 465 PRO F -23
REMARK 465 LEU F -22
REMARK 465 GLN F -21
REMARK 465 PRO F -20
REMARK 465 VAL F -19
REMARK 465 GLN F -18
REMARK 465 HIS F -17
REMARK 465 PRO F -16
REMARK 465 ILE F -15
REMARK 465 LYS F -14
REMARK 465 LYS F -13
REMARK 465 GLU F -12
REMARK 465 HIS F -11
REMARK 465 GLU F -10
REMARK 465 LYS F -9
REMARK 465 LYS F -8
REMARK 465 THR F -7
REMARK 465 VAL F -6
REMARK 465 PRO F -5
REMARK 465 VAL F -4
REMARK 465 LEU F -3
REMARK 465 GLN F -2
REMARK 465 ASP F -1
REMARK 465 ARG F 0
REMARK 465 PRO F 1
REMARK 465 GLU F 2
REMARK 465 ASP F 45
REMARK 465 LYS F 46
REMARK 465 TYR F 47
REMARK 465 TYR F 48
REMARK 465 ASP F 49
REMARK 465 PRO F 50
REMARK 465 VAL F 51
REMARK 465 LEU F 52
REMARK 465 ASN F 53
REMARK 465 LYS F 54
REMARK 465 LYS F 55
REMARK 465 GLY F 56
REMARK 465 LYS F 57
REMARK 465 VAL F 58
REMARK 465 TYR F 59
REMARK 465 ASN F 133
REMARK 465 ARG F 134
REMARK 465 GLN F 135
REMARK 465 SER F 136
REMARK 465 ARG F 137
REMARK 465 ALA F 138
REMARK 465 ASN F 139
REMARK 465 ALA F 140
REMARK 465 THR F 141
REMARK 465 MET F 206
REMARK 465 SER F 207
REMARK 465 MET F 208
REMARK 465 CYS F 209
REMARK 465 GLU F 210
REMARK 465 ALA F 211
REMARK 465 GLY F 212
REMARK 465 MET F 213
REMARK 465 LEU F 214
REMARK 465 SER F 215
REMARK 465 PRO F 216
REMARK 465 ASP F 217
REMARK 465 GLY F 218
REMARK 465 GLN F 219
REMARK 465 CYS F 220
REMARK 465 LYS F 221
REMARK 465 ALA F 222
REMARK 465 PHE F 223
REMARK 465 ASP F 224
REMARK 465 ASN F 225
REMARK 465 LYS F 309
REMARK 465 GLN F 310
REMARK 465 LYS F 428
REMARK 465 ARG F 429
REMARK 465 ASN F 430
REMARK 465 ASP F 431
REMARK 465 ARG F 432
REMARK 465 LEU F 433
REMARK 465 THR F 434
REMARK 465 LYS F 435
REMARK 465 GLN F 436
REMARK 465 HIS F 437
REMARK 465 MET G -172
REMARK 465 GLY G -171
REMARK 465 SER G -170
REMARK 465 SER G -169
REMARK 465 HIS G -168
REMARK 465 HIS G -167
REMARK 465 HIS G -166
REMARK 465 HIS G -165
REMARK 465 HIS G -164
REMARK 465 HIS G -163
REMARK 465 SER G -162
REMARK 465 SER G -161
REMARK 465 GLY G -160
REMARK 465 LEU G -159
REMARK 465 VAL G -158
REMARK 465 PRO G -157
REMARK 465 ARG G -156
REMARK 465 GLY G -155
REMARK 465 SER G -154
REMARK 465 SER G -153
REMARK 465 ALA G -152
REMARK 465 GLU G -151
REMARK 465 GLU G -150
REMARK 465 THR G -149
REMARK 465 ILE G -148
REMARK 465 GLN G -147
REMARK 465 TYR G -146
REMARK 465 ALA G -145
REMARK 465 ALA G -144
REMARK 465 ALA G -143
REMARK 465 GLU G -142
REMARK 465 ILE G -141
REMARK 465 SER G -140
REMARK 465 ALA G -139
REMARK 465 SER G -138
REMARK 465 ARG G -137
REMARK 465 GLN G -136
REMARK 465 TYR G -135
REMARK 465 THR G -134
REMARK 465 VAL G -133
REMARK 465 ALA G -132
REMARK 465 ILE G -131
REMARK 465 GLU G -130
REMARK 465 THR G -129
REMARK 465 LEU G -128
REMARK 465 HIS G -127
REMARK 465 GLU G -126
REMARK 465 ASN G -125
REMARK 465 LEU G -124
REMARK 465 ARG G -123
REMARK 465 GLU G -122
REMARK 465 SER G -121
REMARK 465 ILE G -120
REMARK 465 ALA G -119
REMARK 465 ASP G -118
REMARK 465 VAL G -117
REMARK 465 LEU G -116
REMARK 465 TYR G -115
REMARK 465 MET G -114
REMARK 465 GLU G -113
REMARK 465 PRO G -112
REMARK 465 TYR G -111
REMARK 465 GLU G -110
REMARK 465 VAL G -109
REMARK 465 ASP G -108
REMARK 465 ILE G -107
REMARK 465 ASP G -106
REMARK 465 GLU G -105
REMARK 465 ALA G -104
REMARK 465 PHE G -103
REMARK 465 ILE G -102
REMARK 465 ASP G -101
REMARK 465 ILE G -100
REMARK 465 GLY G -99
REMARK 465 MET G -98
REMARK 465 ASP G -97
REMARK 465 SER G -96
REMARK 465 ILE G -95
REMARK 465 THR G -94
REMARK 465 GLY G -93
REMARK 465 LEU G -92
REMARK 465 GLU G -91
REMARK 465 TRP G -90
REMARK 465 ILE G -89
REMARK 465 LYS G -88
REMARK 465 ALA G -87
REMARK 465 VAL G -86
REMARK 465 ASN G -85
REMARK 465 LYS G -84
REMARK 465 GLN G -83
REMARK 465 TYR G -82
REMARK 465 GLY G -81
REMARK 465 THR G -80
REMARK 465 SER G -79
REMARK 465 PHE G -78
REMARK 465 THR G -77
REMARK 465 VAL G -76
REMARK 465 THR G -75
REMARK 465 ARG G -74
REMARK 465 VAL G -73
REMARK 465 TYR G -72
REMARK 465 ASP G -71
REMARK 465 TYR G -70
REMARK 465 PRO G -69
REMARK 465 THR G -68
REMARK 465 ILE G -67
REMARK 465 ARG G -66
REMARK 465 ASP G -65
REMARK 465 PHE G -64
REMARK 465 ALA G -63
REMARK 465 GLU G -62
REMARK 465 MET G -61
REMARK 465 LEU G -60
REMARK 465 LYS G -59
REMARK 465 SER G -58
REMARK 465 GLU G -57
REMARK 465 LEU G -56
REMARK 465 GLY G -55
REMARK 465 THR G -54
REMARK 465 HIS G -53
REMARK 465 LEU G -52
REMARK 465 ASP G -51
REMARK 465 ARG G -50
REMARK 465 LYS G -49
REMARK 465 ILE G -48
REMARK 465 GLU G -47
REMARK 465 HIS G -46
REMARK 465 THR G -45
REMARK 465 ASP G -44
REMARK 465 SER G -43
REMARK 465 PHE G -42
REMARK 465 GLU G -41
REMARK 465 ALA G -40
REMARK 465 ALA G -39
REMARK 465 GLN G -38
REMARK 465 GLN G -37
REMARK 465 LYS G -36
REMARK 465 PRO G -35
REMARK 465 ALA G -34
REMARK 465 ALA G -33
REMARK 465 SER G -32
REMARK 465 SER G -31
REMARK 465 HIS G -30
REMARK 465 PRO G -29
REMARK 465 LYS G -28
REMARK 465 PRO G -27
REMARK 465 ALA G -26
REMARK 465 GLU G -25
REMARK 465 ARG G -24
REMARK 465 PRO G -23
REMARK 465 LEU G -22
REMARK 465 GLN G -21
REMARK 465 PRO G -20
REMARK 465 VAL G -19
REMARK 465 GLN G -18
REMARK 465 HIS G -17
REMARK 465 PRO G -16
REMARK 465 ILE G -15
REMARK 465 LYS G -14
REMARK 465 LYS G -13
REMARK 465 GLU G -12
REMARK 465 HIS G -11
REMARK 465 GLU G -10
REMARK 465 LYS G -9
REMARK 465 LYS G -8
REMARK 465 THR G -7
REMARK 465 VAL G -6
REMARK 465 PRO G -5
REMARK 465 VAL G -4
REMARK 465 LEU G -3
REMARK 465 GLN G -2
REMARK 465 ASP G -1
REMARK 465 ARG G 0
REMARK 465 PRO G 1
REMARK 465 GLU G 2
REMARK 465 LEU G 52
REMARK 465 ASN G 53
REMARK 465 LYS G 54
REMARK 465 LYS G 55
REMARK 465 GLY G 56
REMARK 465 ARG G 134
REMARK 465 GLN G 135
REMARK 465 SER G 136
REMARK 465 ARG G 137
REMARK 465 ALA G 138
REMARK 465 ASN G 139
REMARK 465 ALA G 140
REMARK 465 THR G 141
REMARK 465 CYS G 209
REMARK 465 GLU G 210
REMARK 465 LYS G 428
REMARK 465 ARG G 429
REMARK 465 ASN G 430
REMARK 465 ASP G 431
REMARK 465 ARG G 432
REMARK 465 LEU G 433
REMARK 465 THR G 434
REMARK 465 LYS G 435
REMARK 465 GLN G 436
REMARK 465 HIS G 437
REMARK 465 ARG G 438
REMARK 465 MET H -172
REMARK 465 GLY H -171
REMARK 465 SER H -170
REMARK 465 SER H -169
REMARK 465 HIS H -168
REMARK 465 HIS H -167
REMARK 465 HIS H -166
REMARK 465 HIS H -165
REMARK 465 HIS H -164
REMARK 465 HIS H -163
REMARK 465 SER H -162
REMARK 465 SER H -161
REMARK 465 GLY H -160
REMARK 465 LEU H -159
REMARK 465 VAL H -158
REMARK 465 PRO H -157
REMARK 465 ARG H -156
REMARK 465 GLY H -155
REMARK 465 SER H -154
REMARK 465 SER H -153
REMARK 465 ALA H -152
REMARK 465 GLU H -151
REMARK 465 GLU H -150
REMARK 465 THR H -149
REMARK 465 ILE H -148
REMARK 465 GLN H -147
REMARK 465 TYR H -146
REMARK 465 ALA H -145
REMARK 465 ALA H -144
REMARK 465 ALA H -143
REMARK 465 GLU H -142
REMARK 465 ILE H -141
REMARK 465 SER H -140
REMARK 465 ALA H -139
REMARK 465 SER H -138
REMARK 465 ARG H -137
REMARK 465 GLN H -136
REMARK 465 TYR H -135
REMARK 465 THR H -134
REMARK 465 VAL H -133
REMARK 465 ALA H -132
REMARK 465 ILE H -131
REMARK 465 GLU H -130
REMARK 465 THR H -129
REMARK 465 LEU H -128
REMARK 465 HIS H -127
REMARK 465 GLU H -126
REMARK 465 ASN H -125
REMARK 465 LEU H -124
REMARK 465 ARG H -123
REMARK 465 GLU H -122
REMARK 465 SER H -121
REMARK 465 ILE H -120
REMARK 465 ALA H -119
REMARK 465 ASP H -118
REMARK 465 VAL H -117
REMARK 465 LEU H -116
REMARK 465 TYR H -115
REMARK 465 MET H -114
REMARK 465 GLU H -113
REMARK 465 PRO H -112
REMARK 465 TYR H -111
REMARK 465 GLU H -110
REMARK 465 VAL H -109
REMARK 465 ASP H -108
REMARK 465 ILE H -107
REMARK 465 ASP H -106
REMARK 465 GLU H -105
REMARK 465 ALA H -104
REMARK 465 PHE H -103
REMARK 465 ILE H -102
REMARK 465 ASP H -101
REMARK 465 ILE H -100
REMARK 465 GLY H -99
REMARK 465 MET H -98
REMARK 465 ASP H -97
REMARK 465 SER H -96
REMARK 465 ILE H -95
REMARK 465 THR H -94
REMARK 465 GLY H -93
REMARK 465 LEU H -92
REMARK 465 GLU H -91
REMARK 465 TRP H -90
REMARK 465 ILE H -89
REMARK 465 LYS H -88
REMARK 465 ALA H -87
REMARK 465 VAL H -86
REMARK 465 ASN H -85
REMARK 465 LYS H -84
REMARK 465 GLN H -83
REMARK 465 TYR H -82
REMARK 465 GLY H -81
REMARK 465 THR H -80
REMARK 465 SER H -79
REMARK 465 PHE H -78
REMARK 465 THR H -77
REMARK 465 VAL H -76
REMARK 465 THR H -75
REMARK 465 ARG H -74
REMARK 465 VAL H -73
REMARK 465 TYR H -72
REMARK 465 ASP H -71
REMARK 465 TYR H -70
REMARK 465 PRO H -69
REMARK 465 THR H -68
REMARK 465 ILE H -67
REMARK 465 ARG H -66
REMARK 465 ASP H -65
REMARK 465 PHE H -64
REMARK 465 ALA H -63
REMARK 465 GLU H -62
REMARK 465 MET H -61
REMARK 465 LEU H -60
REMARK 465 LYS H -59
REMARK 465 SER H -58
REMARK 465 GLU H -57
REMARK 465 LEU H -56
REMARK 465 GLY H -55
REMARK 465 THR H -54
REMARK 465 HIS H -53
REMARK 465 LEU H -52
REMARK 465 ASP H -51
REMARK 465 ARG H -50
REMARK 465 LYS H -49
REMARK 465 ILE H -48
REMARK 465 GLU H -47
REMARK 465 HIS H -46
REMARK 465 THR H -45
REMARK 465 ASP H -44
REMARK 465 SER H -43
REMARK 465 PHE H -42
REMARK 465 GLU H -41
REMARK 465 ALA H -40
REMARK 465 ALA H -39
REMARK 465 GLN H -38
REMARK 465 GLN H -37
REMARK 465 LYS H -36
REMARK 465 PRO H -35
REMARK 465 ALA H -34
REMARK 465 ALA H -33
REMARK 465 SER H -32
REMARK 465 SER H -31
REMARK 465 HIS H -30
REMARK 465 PRO H -29
REMARK 465 LYS H -28
REMARK 465 PRO H -27
REMARK 465 ALA H -26
REMARK 465 GLU H -25
REMARK 465 ARG H -24
REMARK 465 PRO H -23
REMARK 465 LEU H -22
REMARK 465 GLN H -21
REMARK 465 PRO H -20
REMARK 465 VAL H -19
REMARK 465 GLN H -18
REMARK 465 HIS H -17
REMARK 465 PRO H -16
REMARK 465 ILE H -15
REMARK 465 LYS H -14
REMARK 465 LYS H -13
REMARK 465 GLU H -12
REMARK 465 HIS H -11
REMARK 465 GLU H -10
REMARK 465 LYS H -9
REMARK 465 LYS H -8
REMARK 465 THR H -7
REMARK 465 VAL H -6
REMARK 465 PRO H -5
REMARK 465 VAL H -4
REMARK 465 LEU H -3
REMARK 465 GLN H -2
REMARK 465 ASP H -1
REMARK 465 ARG H 0
REMARK 465 PRO H 1
REMARK 465 GLU H 2
REMARK 465 ASP H 45
REMARK 465 LYS H 46
REMARK 465 TYR H 47
REMARK 465 TYR H 48
REMARK 465 ASP H 49
REMARK 465 PRO H 50
REMARK 465 VAL H 51
REMARK 465 LEU H 52
REMARK 465 ASN H 53
REMARK 465 LYS H 54
REMARK 465 LYS H 55
REMARK 465 GLY H 56
REMARK 465 LYS H 57
REMARK 465 VAL H 58
REMARK 465 TYR H 59
REMARK 465 ASN H 133
REMARK 465 ARG H 134
REMARK 465 GLN H 135
REMARK 465 SER H 136
REMARK 465 ARG H 137
REMARK 465 ALA H 138
REMARK 465 ASN H 139
REMARK 465 ALA H 140
REMARK 465 THR H 141
REMARK 465 MET H 206
REMARK 465 SER H 207
REMARK 465 MET H 208
REMARK 465 CYS H 209
REMARK 465 GLU H 210
REMARK 465 ALA H 211
REMARK 465 GLY H 212
REMARK 465 MET H 213
REMARK 465 LEU H 214
REMARK 465 SER H 215
REMARK 465 PRO H 216
REMARK 465 ASP H 217
REMARK 465 GLY H 218
REMARK 465 GLN H 219
REMARK 465 CYS H 220
REMARK 465 LYS H 221
REMARK 465 ALA H 222
REMARK 465 PHE H 223
REMARK 465 ASP H 224
REMARK 465 ASN H 225
REMARK 465 LYS H 309
REMARK 465 GLN H 310
REMARK 465 LYS H 428
REMARK 465 ARG H 429
REMARK 465 ASN H 430
REMARK 465 ASP H 431
REMARK 465 ARG H 432
REMARK 465 LEU H 433
REMARK 465 THR H 434
REMARK 465 LYS H 435
REMARK 465 GLN H 436
REMARK 465 HIS H 437
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 N GLY A 271 OE2 GLU F 377 1.18
REMARK 500 O GLU C 377 OD1 ASN H 270 1.34
REMARK 500 O GLN F 541 CG GLU F 545 1.61
REMARK 500 OD1 ASN A 270 C GLU F 377 1.65
REMARK 500 CH2 TRP F 543 CD1 LEU G 529 1.67
REMARK 500 O THR H 542 CG LYS H 546 1.68
REMARK 500 OD1 ASN A 270 O GLU F 377 1.71
REMARK 500 CE1 PHE F 530 CD2 LEU G 529 1.75
REMARK 500 O GLU C 377 CG ASN H 270 1.76
REMARK 500 CD LYS F 546 O LYS F 566 1.77
REMARK 500 CD1 LEU F 539 CG ASP G 533 1.80
REMARK 500 N HIS C 378 OD1 ASN H 270 1.81
REMARK 500 O ILE F 544 CG LYS F 546 1.82
REMARK 500 NE2 GLN D 541 OE2 GLU D 545 1.84
REMARK 500 OD2 ASP F 533 CD1 LEU G 539 1.85
REMARK 500 ND2 ASN A 270 CA HIS F 378 1.86
REMARK 500 OD1 ASN A 270 N HIS F 378 1.89
REMARK 500 CD1 LEU F 539 OD2 ASP G 533 1.95
REMARK 500 O LEU B 540 CD1 ILE B 544 2.01
REMARK 500 CB THR F 542 OD2 ASP G 535 2.02
REMARK 500 O THR A 542 N LYS A 546 2.03
REMARK 500 O THR C 542 N LYS C 546 2.05
REMARK 500 CA HIS C 378 ND2 ASN H 270 2.06
REMARK 500 OH TYR B 154 OE1 GLU F 377 2.07
REMARK 500 CG ASN A 270 O GLU F 377 2.09
REMARK 500 CB ASP F 535 CB LEU G 539 2.10
REMARK 500 C HIS C 378 ND2 ASN H 270 2.10
REMARK 500 OG1 THR F 542 OD2 ASP G 535 2.12
REMARK 500 OD1 ASN A 270 CA HIS F 378 2.13
REMARK 500 ND2 ASN A 270 C HIS F 378 2.15
REMARK 500 CA HIS C 378 OD1 ASN H 270 2.16
REMARK 500 CG2 THR H 542 CD LYS H 546 2.18
REMARK 500 CG LEU F 539 OD2 ASP G 533 2.18
REMARK 500 N GLY A 271 CD GLU F 377 2.18
REMARK 500 OH TYR B 154 CD GLU F 377 2.18
REMARK 500 O THR D 542 CG LYS D 546 2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE
REMARK 500 O LYS B 547 NE2 HIS E 29 1665 1.53
REMARK 500 O LYS B 547 CD2 HIS E 29 1665 1.78
REMARK 500 CB LEU B 539 CB ASP C 535 1655 1.88
REMARK 500 CD2 LEU B 539 OD2 ASP C 533 1655 1.93
REMARK 500 NZ LYS E 546 OD2 ASP H 535 1656 1.96
REMARK 500 CD1 LEU B 539 OD1 ASP C 533 1655 2.00
REMARK 500 CZ2 TRP B 543 CG ASP C 533 1655 2.04
REMARK 500 CH2 TRP B 543 OD2 ASP C 533 1655 2.05
REMARK 500 NZ LYS C 537 OE2 GLU E 391 1565 2.06
REMARK 500 C LYS B 547 NE2 HIS E 29 1665 2.08
REMARK 500 CZ2 TRP B 543 OD2 ASP C 533 1655 2.09
REMARK 500 CD2 LEU A 529 CD2 LEU D 539 1556 2.10
REMARK 500 OD1 ASP B 533 CD1 LEU C 539 1655 2.11
REMARK 500 CG ASP E 535 CZ2 TRP H 543 1656 2.11
REMARK 500 CD1 LEU A 529 CZ2 TRP D 543 1556 2.16
REMARK 500 OE2 GLU B 396 CD2 HIS H 534 1666 2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 TRP A 24 CE2 TRP A 24 CD2 0.073
REMARK 500 TRP A 42 CE2 TRP A 42 CD2 0.074
REMARK 500 TRP A 395 CE2 TRP A 395 CD2 0.074
REMARK 500 TRP A 543 CE2 TRP A 543 CD2 0.073
REMARK 500 TRP A 556 CE2 TRP A 556 CD2 0.072
REMARK 500 TRP A 564 CE2 TRP A 564 CD2 0.074
REMARK 500 TRP A 589 CE2 TRP A 589 CD2 0.074
REMARK 500 TRP B 24 CE2 TRP B 24 CD2 0.073
REMARK 500 TRP B 42 CE2 TRP B 42 CD2 0.076
REMARK 500 TRP B 395 CE2 TRP B 395 CD2 0.073
REMARK 500 TRP B 543 CE2 TRP B 543 CD2 0.073
REMARK 500 TRP B 556 CE2 TRP B 556 CD2 0.073
REMARK 500 TRP B 564 CE2 TRP B 564 CD2 0.074
REMARK 500 TRP B 589 CE2 TRP B 589 CD2 0.073
REMARK 500 TRP C 24 CE2 TRP C 24 CD2 0.073
REMARK 500 TRP C 42 CE2 TRP C 42 CD2 0.074
REMARK 500 TRP C 395 CE2 TRP C 395 CD2 0.074
REMARK 500 TRP C 543 CE2 TRP C 543 CD2 0.073
REMARK 500 TRP C 556 CE2 TRP C 556 CD2 0.073
REMARK 500 TRP C 564 CE2 TRP C 564 CD2 0.074
REMARK 500 TRP C 589 CE2 TRP C 589 CD2 0.073
REMARK 500 TRP D 24 CE2 TRP D 24 CD2 0.072
REMARK 500 TRP D 42 CE2 TRP D 42 CD2 0.073
REMARK 500 TRP D 395 CE2 TRP D 395 CD2 0.073
REMARK 500 TRP D 556 CE2 TRP D 556 CD2 0.072
REMARK 500 TRP D 564 CE2 TRP D 564 CD2 0.074
REMARK 500 TRP D 589 CE2 TRP D 589 CD2 0.074
REMARK 500 TRP E 24 CE2 TRP E 24 CD2 0.073
REMARK 500 TRP E 42 CE2 TRP E 42 CD2 0.075
REMARK 500 TRP E 395 CE2 TRP E 395 CD2 0.072
REMARK 500 TRP E 543 CE2 TRP E 543 CD2 0.073
REMARK 500 TRP E 556 CE2 TRP E 556 CD2 0.074
REMARK 500 TRP E 564 CE2 TRP E 564 CD2 0.074
REMARK 500 TRP E 589 CE2 TRP E 589 CD2 0.075
REMARK 500 TRP F 24 CE2 TRP F 24 CD2 0.074
REMARK 500 TRP F 42 CE2 TRP F 42 CD2 0.074
REMARK 500 TRP F 395 CE2 TRP F 395 CD2 0.073
REMARK 500 TRP F 543 CE2 TRP F 543 CD2 0.073
REMARK 500 TRP F 556 CE2 TRP F 556 CD2 0.073
REMARK 500 TRP F 564 CE2 TRP F 564 CD2 0.075
REMARK 500 TRP F 589 CE2 TRP F 589 CD2 0.073
REMARK 500 TRP G 24 CE2 TRP G 24 CD2 0.073
REMARK 500 TRP G 42 CE2 TRP G 42 CD2 0.075
REMARK 500 TRP G 395 CE2 TRP G 395 CD2 0.073
REMARK 500 TRP G 543 CE2 TRP G 543 CD2 0.072
REMARK 500 TRP G 556 CE2 TRP G 556 CD2 0.073
REMARK 500 TRP G 564 CE2 TRP G 564 CD2 0.073
REMARK 500 TRP G 589 CE2 TRP G 589 CD2 0.073
REMARK 500 TRP H 24 CE2 TRP H 24 CD2 0.073
REMARK 500 TRP H 42 CE2 TRP H 42 CD2 0.073
REMARK 500
REMARK 500 THIS ENTRY HAS 53 BOND DEVIATIONS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 GLU B 545 CB - CA - C ANGL. DEV. = 30.5 DEGREES
REMARK 500 GLU B 545 N - CA - C ANGL. DEV. = -24.1 DEGREES
REMARK 500 LYS B 546 N - CA - CB ANGL. DEV. = -33.1 DEGREES
REMARK 500 LYS B 546 N - CA - C ANGL. DEV. = 20.3 DEGREES
REMARK 500 ARG B 548 CB - CA - C ANGL. DEV. = -12.1 DEGREES
REMARK 500 ARG B 548 N - CA - C ANGL. DEV. = 21.6 DEGREES
REMARK 500 LYS C 546 CB - CA - C ANGL. DEV. = -38.9 DEGREES
REMARK 500 LYS C 547 C - N - CA ANGL. DEV. = 18.1 DEGREES
REMARK 500 LYS D 546 CB - CA - C ANGL. DEV. = -38.4 DEGREES
REMARK 500 LYS D 546 N - CA - C ANGL. DEV. = 16.3 DEGREES
REMARK 500 LYS D 547 N - CA - C ANGL. DEV. = 16.4 DEGREES
REMARK 500 ARG D 548 CB - CA - C ANGL. DEV. = 12.1 DEGREES
REMARK 500 GLY D 569 N - CA - C ANGL. DEV. = -18.0 DEGREES
REMARK 500 GLU D 570 N - CA - C ANGL. DEV. = 18.7 DEGREES
REMARK 500 LYS F 546 N - CA - C ANGL. DEV. = 36.1 DEGREES
REMARK 500 LYS F 547 N - CA - CB ANGL. DEV. = -15.2 DEGREES
REMARK 500 ARG F 548 CB - CA - C ANGL. DEV. = 14.1 DEGREES
REMARK 500 GLY F 569 N - CA - C ANGL. DEV. = -23.9 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 ARG A 41 -69.35 -92.61
REMARK 500 ASP A 73 75.78 -116.62
REMARK 500 ALA A 168 -126.35 57.46
REMARK 500 PHE A 223 -6.80 77.99
REMARK 500 ASN A 228 30.61 -147.23
REMARK 500 SER A 346 -116.96 61.34
REMARK 500 ASP A 399 -138.67 58.38
REMARK 500 LYS A 546 -7.82 -57.33
REMARK 500 GLU A 585 59.27 -100.50
REMARK 500 ARG B 41 -67.17 -94.94
REMARK 500 ASP B 73 75.88 -116.38
REMARK 500 MET B 124 13.17 -142.47
REMARK 500 ALA B 168 -123.91 56.57
REMARK 500 SER B 346 -117.54 57.41
REMARK 500 ASP B 399 57.62 36.25
REMARK 500 LYS B 546 -18.69 -146.70
REMARK 500 LYS B 547 1.66 85.38
REMARK 500 ARG B 548 57.01 -149.98
REMARK 500 GLU B 585 71.37 -104.63
REMARK 500 ARG C 41 -70.73 -92.32
REMARK 500 ASP C 73 76.41 -117.28
REMARK 500 ALA C 168 -126.88 57.87
REMARK 500 PHE C 223 -7.65 81.32
REMARK 500 ASN C 228 30.15 -145.12
REMARK 500 SER C 346 -118.28 57.42
REMARK 500 ASP C 399 -139.84 57.47
REMARK 500 LYS C 546 39.78 -93.55
REMARK 500 LYS C 547 -7.71 78.96
REMARK 500 ARG D 41 -67.43 -93.94
REMARK 500 MET D 124 13.10 -142.87
REMARK 500 ALA D 168 -124.78 57.93
REMARK 500 SER D 346 -117.55 55.10
REMARK 500 ASP D 399 58.65 38.66
REMARK 500 LYS D 546 68.89 -108.64
REMARK 500 LYS D 547 -56.03 75.74
REMARK 500 GLU D 570 11.76 -62.32
REMARK 500 GLU D 585 62.04 -105.16
REMARK 500 ARG E 41 -73.12 -92.69
REMARK 500 ASP E 73 75.62 -118.17
REMARK 500 ALA E 168 -124.44 56.13
REMARK 500 SER E 207 112.08 -39.74
REMARK 500 PHE E 223 -11.28 78.74
REMARK 500 ASN E 228 31.77 -148.99
REMARK 500 SER E 346 -114.47 54.41
REMARK 500 ASP E 399 -138.31 55.60
REMARK 500 GLU E 585 57.87 -98.90
REMARK 500 ARG F 41 -66.78 -92.47
REMARK 500 ASP F 73 75.43 -118.68
REMARK 500 MET F 124 21.01 -148.34
REMARK 500 ALA F 168 -130.56 61.26
REMARK 500
REMARK 500 THIS ENTRY HAS 70 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 GLU B 570 TYR B 571 144.22
REMARK 500 LYS C 546 LYS C 547 141.38
REMARK 500 GLU D 570 TYR D 571 144.97
REMARK 500 GLU F 570 TYR F 571 144.64
REMARK 500 GLU H 570 TYR H 571 146.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 5ERF RELATED DB: PDB
REMARK 900 RELATED ID: 5ERB RELATED DB: PDB
REMARK 900 RELATED ID: 5ELP RELATED DB: PDB
DBREF 5ENY A -152 591 UNP Q05470 PKSL_BACSU 2719 3462
DBREF 5ENY B -152 591 UNP Q05470 PKSL_BACSU 2719 3462
DBREF 5ENY C -152 591 UNP Q05470 PKSL_BACSU 2719 3462
DBREF 5ENY D -152 591 UNP Q05470 PKSL_BACSU 2719 3462
DBREF 5ENY E -152 591 UNP Q05470 PKSL_BACSU 2719 3462
DBREF 5ENY F -152 591 UNP Q05470 PKSL_BACSU 2719 3462
DBREF 5ENY G -152 591 UNP Q05470 PKSL_BACSU 2719 3462
DBREF 5ENY H -152 591 UNP Q05470 PKSL_BACSU 2719 3462
SEQADV 5ENY MET A -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY A -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER A -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER A -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS A -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS A -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS A -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS A -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS A -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS A -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER A -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER A -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY A -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU A -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL A -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO A -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG A -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY A -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER A -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER A -153 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY MET B -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY B -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER B -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER B -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS B -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS B -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS B -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS B -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS B -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS B -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER B -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER B -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY B -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU B -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL B -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO B -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG B -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY B -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER B -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER B -153 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY MET C -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY C -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER C -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER C -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS C -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS C -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS C -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS C -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS C -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS C -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER C -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER C -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY C -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU C -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL C -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO C -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG C -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY C -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER C -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER C -153 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY MET D -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY D -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER D -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER D -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS D -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS D -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS D -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS D -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS D -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS D -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER D -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER D -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY D -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU D -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL D -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO D -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG D -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY D -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER D -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER D -153 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY MET E -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY E -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER E -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER E -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS E -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS E -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS E -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS E -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS E -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS E -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER E -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER E -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY E -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU E -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL E -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO E -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG E -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY E -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER E -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER E -153 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY MET F -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY F -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER F -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER F -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS F -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS F -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS F -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS F -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS F -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS F -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER F -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER F -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY F -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU F -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL F -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO F -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG F -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY F -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER F -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER F -153 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY MET G -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY G -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER G -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER G -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS G -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS G -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS G -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS G -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS G -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS G -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER G -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER G -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY G -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU G -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL G -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO G -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG G -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY G -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER G -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER G -153 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY MET H -172 UNP Q05470 INITIATING METHIONINE
SEQADV 5ENY GLY H -171 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER H -170 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER H -169 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS H -168 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS H -167 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS H -166 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS H -165 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS H -164 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY HIS H -163 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER H -162 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER H -161 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY H -160 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY LEU H -159 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY VAL H -158 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY PRO H -157 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY ARG H -156 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY GLY H -155 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER H -154 UNP Q05470 EXPRESSION TAG
SEQADV 5ENY SER H -153 UNP Q05470 EXPRESSION TAG
SEQRES 1 A 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 A 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 A 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 A 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 A 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 A 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 A 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 A 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 A 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 A 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 A 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 A 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 A 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 A 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 A 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 A 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 A 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 A 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 A 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 A 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 A 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 A 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 A 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 A 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 A 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 A 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 A 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 A 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 A 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 A 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 A 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 A 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 A 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 A 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 A 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 A 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 A 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 A 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 A 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 A 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 A 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 A 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 A 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 A 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 A 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 A 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 A 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 A 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 A 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 A 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 A 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 A 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 A 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 A 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 A 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 A 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 A 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 A 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 A 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
SEQRES 1 B 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 B 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 B 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 B 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 B 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 B 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 B 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 B 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 B 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 B 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 B 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 B 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 B 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 B 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 B 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 B 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 B 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 B 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 B 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 B 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 B 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 B 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 B 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 B 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 B 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 B 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 B 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 B 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 B 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 B 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 B 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 B 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 B 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 B 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 B 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 B 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 B 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 B 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 B 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 B 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 B 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 B 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 B 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 B 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 B 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 B 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 B 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 B 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 B 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 B 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 B 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 B 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 B 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 B 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 B 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 B 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 B 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 B 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 B 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
SEQRES 1 C 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 C 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 C 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 C 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 C 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 C 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 C 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 C 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 C 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 C 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 C 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 C 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 C 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 C 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 C 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 C 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 C 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 C 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 C 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 C 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 C 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 C 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 C 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 C 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 C 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 C 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 C 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 C 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 C 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 C 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 C 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 C 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 C 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 C 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 C 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 C 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 C 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 C 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 C 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 C 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 C 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 C 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 C 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 C 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 C 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 C 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 C 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 C 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 C 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 C 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 C 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 C 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 C 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 C 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 C 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 C 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 C 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 C 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 C 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
SEQRES 1 D 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 D 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 D 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 D 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 D 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 D 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 D 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 D 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 D 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 D 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 D 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 D 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 D 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 D 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 D 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 D 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 D 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 D 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 D 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 D 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 D 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 D 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 D 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 D 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 D 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 D 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 D 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 D 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 D 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 D 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 D 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 D 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 D 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 D 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 D 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 D 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 D 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 D 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 D 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 D 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 D 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 D 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 D 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 D 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 D 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 D 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 D 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 D 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 D 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 D 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 D 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 D 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 D 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 D 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 D 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 D 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 D 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 D 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 D 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
SEQRES 1 E 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 E 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 E 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 E 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 E 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 E 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 E 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 E 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 E 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 E 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 E 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 E 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 E 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 E 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 E 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 E 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 E 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 E 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 E 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 E 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 E 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 E 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 E 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 E 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 E 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 E 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 E 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 E 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 E 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 E 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 E 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 E 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 E 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 E 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 E 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 E 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 E 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 E 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 E 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 E 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 E 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 E 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 E 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 E 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 E 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 E 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 E 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 E 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 E 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 E 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 E 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 E 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 E 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 E 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 E 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 E 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 E 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 E 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 E 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
SEQRES 1 F 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 F 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 F 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 F 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 F 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 F 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 F 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 F 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 F 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 F 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 F 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 F 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 F 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 F 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 F 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 F 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 F 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 F 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 F 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 F 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 F 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 F 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 F 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 F 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 F 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 F 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 F 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 F 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 F 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 F 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 F 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 F 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 F 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 F 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 F 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 F 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 F 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 F 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 F 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 F 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 F 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 F 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 F 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 F 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 F 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 F 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 F 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 F 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 F 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 F 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 F 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 F 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 F 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 F 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 F 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 F 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 F 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 F 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 F 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
SEQRES 1 G 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 G 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 G 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 G 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 G 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 G 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 G 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 G 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 G 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 G 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 G 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 G 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 G 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 G 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 G 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 G 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 G 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 G 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 G 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 G 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 G 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 G 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 G 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 G 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 G 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 G 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 G 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 G 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 G 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 G 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 G 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 G 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 G 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 G 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 G 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 G 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 G 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 G 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 G 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 G 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 G 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 G 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 G 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 G 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 G 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 G 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 G 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 G 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 G 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 G 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 G 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 G 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 G 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 G 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 G 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 G 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 G 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 G 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 G 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
SEQRES 1 H 764 MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES 2 H 764 LEU VAL PRO ARG GLY SER SER ALA GLU GLU THR ILE GLN
SEQRES 3 H 764 TYR ALA ALA ALA GLU ILE SER ALA SER ARG GLN TYR THR
SEQRES 4 H 764 VAL ALA ILE GLU THR LEU HIS GLU ASN LEU ARG GLU SER
SEQRES 5 H 764 ILE ALA ASP VAL LEU TYR MET GLU PRO TYR GLU VAL ASP
SEQRES 6 H 764 ILE ASP GLU ALA PHE ILE ASP ILE GLY MET ASP SER ILE
SEQRES 7 H 764 THR GLY LEU GLU TRP ILE LYS ALA VAL ASN LYS GLN TYR
SEQRES 8 H 764 GLY THR SER PHE THR VAL THR ARG VAL TYR ASP TYR PRO
SEQRES 9 H 764 THR ILE ARG ASP PHE ALA GLU MET LEU LYS SER GLU LEU
SEQRES 10 H 764 GLY THR HIS LEU ASP ARG LYS ILE GLU HIS THR ASP SER
SEQRES 11 H 764 PHE GLU ALA ALA GLN GLN LYS PRO ALA ALA SER SER HIS
SEQRES 12 H 764 PRO LYS PRO ALA GLU ARG PRO LEU GLN PRO VAL GLN HIS
SEQRES 13 H 764 PRO ILE LYS LYS GLU HIS GLU LYS LYS THR VAL PRO VAL
SEQRES 14 H 764 LEU GLN ASP ARG PRO GLU ASP ALA ILE ALA ILE VAL GLY
SEQRES 15 H 764 MET SER GLY ARG TYR PRO GLY ALA ARG ASN VAL ARG GLU
SEQRES 16 H 764 TYR TRP ASP ASN LEU VAL HIS ALA ARG ASN ALA ILE ARG
SEQRES 17 H 764 ASP ILE PRO THR SER ARG TRP ASP VAL ASP LYS TYR TYR
SEQRES 18 H 764 ASP PRO VAL LEU ASN LYS LYS GLY LYS VAL TYR CYS LYS
SEQRES 19 H 764 SER MET GLY MET LEU ASP ASP ILE GLU HIS PHE ASP PRO
SEQRES 20 H 764 LEU PHE PHE ASN ILE PRO PRO SER GLU ALA GLU LEU MET
SEQRES 21 H 764 ASP PRO GLN HIS ARG ILE PHE LEU GLN GLU GLY TYR LYS
SEQRES 22 H 764 ALA PHE GLU ASP ALA GLY TYR ASN ALA ARG THR LEU ASN
SEQRES 23 H 764 GLU LYS LYS CYS GLY VAL TYR LEU GLY ILE MET SER ASN
SEQRES 24 H 764 GLU TYR GLY VAL MET LEU ASN ARG GLN SER ARG ALA ASN
SEQRES 25 H 764 ALA THR GLY ASN SER PHE ALA ILE ALA ALA ALA ARG ILE
SEQRES 26 H 764 PRO TYR PHE LEU ASN LEU LYS GLY PRO ALA ILE PRO ILE
SEQRES 27 H 764 ASP THR ALA CYS SER SER SER LEU VAL GLY THR HIS LEU
SEQRES 28 H 764 ALA ARG GLN ALA LEU ILE ASN LYS GLU ILE ASP MET ALA
SEQRES 29 H 764 LEU VAL GLY GLY VAL SER LEU TYR LEU THR PRO GLU SER
SEQRES 30 H 764 TYR MET SER MET CYS GLU ALA GLY MET LEU SER PRO ASP
SEQRES 31 H 764 GLY GLN CYS LYS ALA PHE ASP ASN GLY ALA ASN GLY PHE
SEQRES 32 H 764 VAL PRO GLY GLU GLY ALA GLY ALA LEU VAL LEU LYS ARG
SEQRES 33 H 764 LEU LYS ASP ALA GLU ALA ASP ARG ASP HIS ILE TYR GLY
SEQRES 34 H 764 ILE ILE ILE GLY SER GLY ILE ASN GLN ASP GLY LYS THR
SEQRES 35 H 764 ASN GLY ILE THR ALA PRO SER ALA LYS SER GLN MET ASP
SEQRES 36 H 764 LEU GLU ARG ASP ILE TYR GLU THR TYR GLY ILE HIS PRO
SEQRES 37 H 764 GLU SER ILE SER TYR VAL GLU MET HIS GLY THR GLY THR
SEQRES 38 H 764 LYS GLN GLY ASP PRO ILE GLU LEU GLU ALA LEU SER THR
SEQRES 39 H 764 VAL PHE GLN GLU LYS THR ASP LYS LYS GLN PHE CYS ALA
SEQRES 40 H 764 ILE GLY SER VAL LYS SER ASN ILE GLY HIS THR SER ALA
SEQRES 41 H 764 ALA ALA GLY VAL ALA GLY VAL GLN LYS VAL LEU LEU CYS
SEQRES 42 H 764 MET ASN HIS LYS THR LEU VAL PRO THR LEU ASN PHE THR
SEQRES 43 H 764 THR PRO ASN GLU HIS PHE GLU PHE GLU HIS SER PRO LEU
SEQRES 44 H 764 TYR VAL ASN THR GLU LEU LYS PRO TRP GLU THR ALA ASP
SEQRES 45 H 764 GLY LYS PRO ARG ARG ALA CYS VAL SER SER PHE GLY TYR
SEQRES 46 H 764 SER GLY THR ASN ALA HIS ILE VAL ILE GLU GLU TYR GLN
SEQRES 47 H 764 PRO GLU LYS ARG ASN ASP ARG LEU THR LYS GLN HIS ARG
SEQRES 48 H 764 SER ALA LEU PHE VAL LEU SER ALA LYS LYS GLU LYS GLN
SEQRES 49 H 764 LEU LYS ALA TYR ALA GLU ALA MET LYS ASP PHE VAL THR
SEQRES 50 H 764 SER ASN GLU ASP ILE ASP LEU GLU ASP MET ALA TYR THR
SEQRES 51 H 764 LEU GLN THR GLY ARG GLU ALA MET ASP TYR ARG MET ALA
SEQRES 52 H 764 PHE LEU ALA ASP SER ARG GLU MET LEU ILE LYS ALA LEU
SEQRES 53 H 764 ASP ASP TYR LEU ALA GLU MET PRO ASN GLY SER ILE PHE
SEQRES 54 H 764 ALA ALA HIS VAL LYS THR LYS LYS SER GLU ILE LYS LEU
SEQRES 55 H 764 PHE GLU THR ASP HIS ASP ALA LYS ALA LEU LEU GLN THR
SEQRES 56 H 764 TRP ILE GLU LYS LYS ARG LEU GLU LYS VAL ALA GLU LEU
SEQRES 57 H 764 TRP VAL LYS GLY LEU GLN ILE ASP TRP ASN LYS LEU TYR
SEQRES 58 H 764 GLY GLU TYR THR PRO ARG ARG ILE SER LEU PRO ALA TYR
SEQRES 59 H 764 PRO PHE ALA GLU GLU TYR TYR TRP LEU PRO
HELIX 1 AA1 ASN A 19 HIS A 29 1 11
HELIX 2 AA2 ASP A 43 TYR A 47 5 5
HELIX 3 AA3 PRO A 80 GLU A 85 1 6
HELIX 4 AA4 ASP A 88 GLY A 106 1 19
HELIX 5 AA5 ASN A 108 ASN A 113 1 6
HELIX 6 AA6 ASN A 126 ASN A 133 1 8
HELIX 7 AA7 SER A 144 ASN A 157 1 14
HELIX 8 AA8 THR A 167 CYS A 169 5 3
HELIX 9 AA9 SER A 170 ASN A 185 1 16
HELIX 10 AB1 THR A 201 SER A 207 1 7
HELIX 11 AB2 LEU A 244 ASP A 250 1 7
HELIX 12 AB3 SER A 276 GLY A 292 1 17
HELIX 13 AB4 HIS A 294 ILE A 298 5 5
HELIX 14 AB5 GLN A 310 GLU A 325 1 16
HELIX 15 AB6 VAL A 338 GLY A 343 1 6
HELIX 16 AB7 THR A 345 ALA A 347 5 3
HELIX 17 AB8 ALA A 348 HIS A 363 1 16
HELIX 18 AB9 LYS A 448 ASN A 466 1 19
HELIX 19 AC1 ASP A 470 GLY A 481 1 12
HELIX 20 AC2 SER A 495 GLU A 509 1 15
HELIX 21 AC3 LYS A 523 ASP A 533 1 11
HELIX 22 AC4 ASP A 533 LYS A 547 1 15
HELIX 23 AC5 ARG A 548 GLY A 559 1 12
HELIX 24 AC6 ASP A 563 TYR A 568 5 6
HELIX 25 AC7 ASN B 19 HIS B 29 1 11
HELIX 26 AC8 PRO B 80 GLU B 85 1 6
HELIX 27 AC9 ASP B 88 GLY B 106 1 19
HELIX 28 AD1 ASN B 108 ASN B 113 1 6
HELIX 29 AD2 ASN B 126 LEU B 132 1 7
HELIX 30 AD3 SER B 144 ASN B 157 1 14
HELIX 31 AD4 THR B 167 CYS B 169 5 3
HELIX 32 AD5 SER B 170 ASN B 185 1 16
HELIX 33 AD6 LEU B 244 ASP B 250 1 7
HELIX 34 AD7 SER B 276 TYR B 291 1 16
HELIX 35 AD8 HIS B 294 ILE B 298 5 5
HELIX 36 AD9 ASP B 312 GLU B 325 1 14
HELIX 37 AE1 VAL B 338 GLY B 343 1 6
HELIX 38 AE2 THR B 345 ALA B 347 5 3
HELIX 39 AE3 ALA B 348 HIS B 363 1 16
HELIX 40 AE4 LYS B 448 ASN B 466 1 19
HELIX 41 AE5 ASP B 470 GLY B 481 1 12
HELIX 42 AE6 SER B 495 GLU B 509 1 15
HELIX 43 AE7 LYS B 523 THR B 532 1 10
HELIX 44 AE8 ASP B 533 LYS B 546 1 14
HELIX 45 AE9 ARG B 548 GLY B 559 1 12
HELIX 46 AF1 ASP B 563 TYR B 568 5 6
HELIX 47 AF2 ASN C 19 HIS C 29 1 11
HELIX 48 AF3 ASP C 43 TYR C 47 5 5
HELIX 49 AF4 PRO C 80 GLU C 85 1 6
HELIX 50 AF5 ASP C 88 GLY C 106 1 19
HELIX 51 AF6 ASN C 108 ASN C 113 1 6
HELIX 52 AF7 ASN C 126 ASN C 133 1 8
HELIX 53 AF8 SER C 144 ASN C 157 1 14
HELIX 54 AF9 THR C 167 CYS C 169 5 3
HELIX 55 AG1 SER C 170 ASN C 185 1 16
HELIX 56 AG2 THR C 201 SER C 207 1 7
HELIX 57 AG3 LEU C 244 ASP C 250 1 7
HELIX 58 AG4 SER C 276 TYR C 291 1 16
HELIX 59 AG5 HIS C 294 ILE C 298 5 5
HELIX 60 AG6 GLN C 310 GLU C 325 1 16
HELIX 61 AG7 VAL C 338 GLY C 343 1 6
HELIX 62 AG8 THR C 345 ALA C 347 5 3
HELIX 63 AG9 ALA C 348 LYS C 364 1 17
HELIX 64 AH1 LYS C 448 ASN C 466 1 19
HELIX 65 AH2 ASP C 470 GLY C 481 1 12
HELIX 66 AH3 SER C 495 GLU C 509 1 15
HELIX 67 AH4 LYS C 523 ASP C 533 1 11
HELIX 68 AH5 ASP C 533 LYS C 546 1 14
HELIX 69 AH6 ARG C 548 GLY C 559 1 12
HELIX 70 AH7 ASP C 563 TYR C 568 5 6
HELIX 71 AH8 ASN D 19 HIS D 29 1 11
HELIX 72 AH9 PRO D 80 GLU D 85 1 6
HELIX 73 AI1 ASP D 88 GLY D 106 1 19
HELIX 74 AI2 ASN D 108 ASN D 113 1 6
HELIX 75 AI3 ASN D 126 LEU D 132 1 7
HELIX 76 AI4 SER D 144 ASN D 157 1 14
HELIX 77 AI5 THR D 167 CYS D 169 5 3
HELIX 78 AI6 SER D 170 ASN D 185 1 16
HELIX 79 AI7 LEU D 244 ASP D 250 1 7
HELIX 80 AI8 SER D 276 TYR D 291 1 16
HELIX 81 AI9 HIS D 294 ILE D 298 5 5
HELIX 82 AJ1 ASP D 312 GLU D 325 1 14
HELIX 83 AJ2 VAL D 338 GLY D 343 1 6
HELIX 84 AJ3 THR D 345 ALA D 347 5 3
HELIX 85 AJ4 ALA D 348 HIS D 363 1 16
HELIX 86 AJ5 LYS D 448 ASN D 466 1 19
HELIX 87 AJ6 ASP D 470 GLY D 481 1 12
HELIX 88 AJ7 SER D 495 GLU D 509 1 15
HELIX 89 AJ8 LYS D 523 THR D 532 1 10
HELIX 90 AJ9 ASP D 533 LYS D 546 1 14
HELIX 91 AK1 LEU D 549 GLY D 559 1 11
HELIX 92 AK2 ASP D 563 TYR D 568 5 6
HELIX 93 AK3 ASN E 19 HIS E 29 1 11
HELIX 94 AK4 ASP E 43 TYR E 47 5 5
HELIX 95 AK5 PRO E 80 GLU E 85 1 6
HELIX 96 AK6 ASP E 88 GLY E 106 1 19
HELIX 97 AK7 ASN E 108 ASN E 113 1 6
HELIX 98 AK8 ASN E 126 ASN E 133 1 8
HELIX 99 AK9 SER E 144 ASN E 157 1 14
HELIX 100 AL1 THR E 167 CYS E 169 5 3
HELIX 101 AL2 SER E 170 ASN E 185 1 16
HELIX 102 AL3 THR E 201 SER E 207 1 7
HELIX 103 AL4 LEU E 244 ASP E 250 1 7
HELIX 104 AL5 SER E 276 TYR E 291 1 16
HELIX 105 AL6 HIS E 294 ILE E 298 5 5
HELIX 106 AL7 GLN E 310 GLU E 325 1 16
HELIX 107 AL8 VAL E 338 GLY E 343 1 6
HELIX 108 AL9 THR E 345 ALA E 347 5 3
HELIX 109 AM1 ALA E 348 LYS E 364 1 17
HELIX 110 AM2 LYS E 448 ASN E 466 1 19
HELIX 111 AM3 ASP E 470 GLY E 481 1 12
HELIX 112 AM4 SER E 495 GLU E 509 1 15
HELIX 113 AM5 LYS E 521 LYS E 523 5 3
HELIX 114 AM6 ILE E 527 ASP E 533 1 7
HELIX 115 AM7 ASP E 533 LYS E 547 1 15
HELIX 116 AM8 ARG E 548 GLY E 559 1 12
HELIX 117 AM9 ASP E 563 TYR E 568 5 6
HELIX 118 AN1 ASN F 19 HIS F 29 1 11
HELIX 119 AN2 PRO F 80 GLU F 85 1 6
HELIX 120 AN3 ASP F 88 GLY F 106 1 19
HELIX 121 AN4 ASN F 108 ASN F 113 1 6
HELIX 122 AN5 ASN F 126 LEU F 132 1 7
HELIX 123 AN6 SER F 144 ASN F 157 1 14
HELIX 124 AN7 THR F 167 CYS F 169 5 3
HELIX 125 AN8 SER F 170 ASN F 185 1 16
HELIX 126 AN9 LEU F 244 ASP F 250 1 7
HELIX 127 AO1 SER F 276 TYR F 291 1 16
HELIX 128 AO2 HIS F 294 ILE F 298 5 5
HELIX 129 AO3 ASP F 312 GLU F 325 1 14
HELIX 130 AO4 VAL F 338 GLY F 343 1 6
HELIX 131 AO5 THR F 345 ALA F 347 5 3
HELIX 132 AO6 ALA F 348 HIS F 363 1 16
HELIX 133 AO7 LYS F 448 ASN F 466 1 19
HELIX 134 AO8 ASP F 470 GLY F 481 1 12
HELIX 135 AO9 SER F 495 GLU F 509 1 15
HELIX 136 AP1 LYS F 523 THR F 532 1 10
HELIX 137 AP2 ASP F 533 ILE F 544 1 12
HELIX 138 AP3 LEU F 549 GLY F 559 1 11
HELIX 139 AP4 ASP F 563 TYR F 568 5 6
HELIX 140 AP5 ASN G 19 HIS G 29 1 11
HELIX 141 AP6 ASP G 43 TYR G 47 5 5
HELIX 142 AP7 PRO G 80 GLU G 85 1 6
HELIX 143 AP8 ASP G 88 GLY G 106 1 19
HELIX 144 AP9 ASN G 108 ASN G 113 1 6
HELIX 145 AQ1 ASN G 126 ASN G 133 1 8
HELIX 146 AQ2 SER G 144 ASN G 157 1 14
HELIX 147 AQ3 THR G 167 CYS G 169 5 3
HELIX 148 AQ4 SER G 170 ASN G 185 1 16
HELIX 149 AQ5 THR G 201 SER G 207 1 7
HELIX 150 AQ6 LEU G 244 ASP G 250 1 7
HELIX 151 AQ7 SER G 276 GLY G 292 1 17
HELIX 152 AQ8 HIS G 294 ILE G 298 5 5
HELIX 153 AQ9 GLN G 310 GLU G 325 1 16
HELIX 154 AR1 VAL G 338 GLY G 343 1 6
HELIX 155 AR2 THR G 345 ALA G 347 5 3
HELIX 156 AR3 ALA G 348 LYS G 364 1 17
HELIX 157 AR4 LYS G 448 ASN G 466 1 19
HELIX 158 AR5 ASP G 470 GLY G 481 1 12
HELIX 159 AR6 SER G 495 GLU G 509 1 15
HELIX 160 AR7 LYS G 523 ASP G 533 1 11
HELIX 161 AR8 ASP G 533 LYS G 546 1 14
HELIX 162 AR9 ARG G 548 GLY G 559 1 12
HELIX 163 AS1 ASP G 563 TYR G 568 5 6
HELIX 164 AS2 ASN H 19 HIS H 29 1 11
HELIX 165 AS3 PRO H 80 GLU H 85 1 6
HELIX 166 AS4 ASP H 88 GLY H 106 1 19
HELIX 167 AS5 ASN H 108 ASN H 113 1 6
HELIX 168 AS6 ASN H 126 LEU H 132 1 7
HELIX 169 AS7 SER H 144 ASN H 157 1 14
HELIX 170 AS8 THR H 167 CYS H 169 5 3
HELIX 171 AS9 SER H 170 ASN H 185 1 16
HELIX 172 AT1 LEU H 244 ASP H 250 1 7
HELIX 173 AT2 SER H 276 GLY H 292 1 17
HELIX 174 AT3 HIS H 294 ILE H 298 5 5
HELIX 175 AT4 ASP H 312 GLU H 325 1 14
HELIX 176 AT5 VAL H 338 GLY H 343 1 6
HELIX 177 AT6 THR H 345 ALA H 347 5 3
HELIX 178 AT7 ALA H 348 HIS H 363 1 16
HELIX 179 AT8 LYS H 448 ASN H 466 1 19
HELIX 180 AT9 ASP H 470 GLY H 481 1 12
HELIX 181 AU1 SER H 495 GLU H 509 1 15
HELIX 182 AU2 LYS H 523 THR H 532 1 10
HELIX 183 AU3 ASP H 533 LYS H 547 1 15
HELIX 184 AU4 ARG H 548 GLY H 559 1 12
HELIX 185 AU5 ASP H 563 TYR H 568 5 6
SHEET 1 AA111 ALA A 162 ILE A 165 0
SHEET 2 AA111 CYS A 117 GLY A 122 1 N LEU A 121 O ILE A 165
SHEET 3 AA111 MET A 190 SER A 197 1 O LEU A 192 N GLY A 118
SHEET 4 AA111 GLY A 235 ARG A 243 -1 O LEU A 241 N ALA A 191
SHEET 5 AA111 ILE A 5 ARG A 13 -1 N SER A 11 O ALA A 238
SHEET 6 AA111 GLY A 256 GLN A 265 -1 O ILE A 258 N ILE A 5
SHEET 7 AA111 THR A 415 GLU A 422 -1 O VAL A 420 N GLY A 260
SHEET 8 AA111 ARG A 404 PHE A 410 -1 N ALA A 405 O ILE A 421
SHEET 9 AA111 TYR A 300 GLU A 302 1 N GLU A 302 O CYS A 406
SHEET 10 AA111 CYS A 333 GLY A 336 1 O ALA A 334 N VAL A 301
SHEET 11 AA111 LEU A 386 VAL A 388 1 O TYR A 387 N CYS A 333
SHEET 1 AA2 2 ARG A 35 ASP A 36 0
SHEET 2 AA2 2 SER A 62 MET A 63 -1 O MET A 63 N ARG A 35
SHEET 1 AA3 2 HIS A 71 PHE A 72 0
SHEET 2 AA3 2 GLU A 586 TYR A 587 -1 O GLU A 586 N PHE A 72
SHEET 1 AA4 2 THR A 365 LEU A 366 0
SHEET 2 AA4 2 LYS A 393 PRO A 394 -1 O LYS A 393 N LEU A 366
SHEET 1 AA5 3 ALA A 440 ALA A 446 0
SHEET 2 AA5 3 TYR A 487 ALA A 493 -1 O ALA A 493 N ALA A 440
SHEET 3 AA5 3 ILE A 515 HIS A 519 -1 O PHE A 516 N ALA A 490
SHEET 1 AA611 ALA B 162 ILE B 165 0
SHEET 2 AA611 CYS B 117 GLY B 122 1 N LEU B 121 O ILE B 165
SHEET 3 AA611 MET B 190 SER B 197 1 O LEU B 192 N GLY B 118
SHEET 4 AA611 GLY B 235 ARG B 243 -1 O LEU B 239 N VAL B 193
SHEET 5 AA611 ILE B 5 ARG B 13 -1 N GLY B 9 O VAL B 240
SHEET 6 AA611 GLY B 256 GLN B 265 -1 O ILE B 258 N ILE B 5
SHEET 7 AA611 THR B 415 GLU B 422 -1 O VAL B 420 N GLY B 260
SHEET 8 AA611 ARG B 404 PHE B 410 -1 N ALA B 405 O ILE B 421
SHEET 9 AA611 TYR B 300 GLU B 302 1 N GLU B 302 O CYS B 406
SHEET 10 AA611 CYS B 333 GLY B 336 1 O ALA B 334 N VAL B 301
SHEET 11 AA611 LEU B 386 VAL B 388 1 O TYR B 387 N CYS B 333
SHEET 1 AA7 2 ILE B 34 ASP B 36 0
SHEET 2 AA7 2 SER B 62 GLY B 64 -1 O MET B 63 N ARG B 35
SHEET 1 AA8 2 HIS B 71 PHE B 72 0
SHEET 2 AA8 2 GLU B 586 TYR B 587 -1 O GLU B 586 N PHE B 72
SHEET 1 AA9 2 THR B 365 LEU B 366 0
SHEET 2 AA9 2 LYS B 393 PRO B 394 -1 O LYS B 393 N LEU B 366
SHEET 1 AB1 3 ALA B 440 ALA B 446 0
SHEET 2 AB1 3 TYR B 487 ALA B 493 -1 O MET B 489 N LEU B 444
SHEET 3 AB1 3 ILE B 515 HIS B 519 -1 O PHE B 516 N ALA B 490
SHEET 1 AB211 ALA C 162 ILE C 165 0
SHEET 2 AB211 CYS C 117 GLY C 122 1 N LEU C 121 O ILE C 165
SHEET 3 AB211 MET C 190 SER C 197 1 O GLY C 194 N GLY C 122
SHEET 4 AB211 GLY C 235 ARG C 243 -1 O LEU C 239 N VAL C 193
SHEET 5 AB211 ILE C 5 ARG C 13 -1 N ALA C 6 O LYS C 242
SHEET 6 AB211 GLY C 256 GLN C 265 -1 O ILE C 258 N ILE C 5
SHEET 7 AB211 THR C 415 GLU C 422 -1 O VAL C 420 N GLY C 260
SHEET 8 AB211 ARG C 404 PHE C 410 -1 N ALA C 405 O ILE C 421
SHEET 9 AB211 TYR C 300 GLU C 302 1 N GLU C 302 O CYS C 406
SHEET 10 AB211 CYS C 333 GLY C 336 1 O ALA C 334 N VAL C 301
SHEET 11 AB211 LEU C 386 VAL C 388 1 O TYR C 387 N ILE C 335
SHEET 1 AB3 2 ILE C 34 ASP C 36 0
SHEET 2 AB3 2 SER C 62 GLY C 64 -1 O MET C 63 N ARG C 35
SHEET 1 AB4 2 HIS C 71 PHE C 72 0
SHEET 2 AB4 2 GLU C 586 TYR C 587 -1 O GLU C 586 N PHE C 72
SHEET 1 AB5 2 THR C 365 LEU C 366 0
SHEET 2 AB5 2 LYS C 393 PRO C 394 -1 O LYS C 393 N LEU C 366
SHEET 1 AB6 3 ALA C 440 ALA C 446 0
SHEET 2 AB6 3 TYR C 487 ALA C 493 -1 O ALA C 493 N ALA C 440
SHEET 3 AB6 3 ILE C 515 HIS C 519 -1 O PHE C 516 N ALA C 490
SHEET 1 AB711 ALA D 162 ILE D 165 0
SHEET 2 AB711 CYS D 117 GLY D 122 1 N LEU D 121 O ILE D 165
SHEET 3 AB711 MET D 190 SER D 197 1 O GLY D 194 N GLY D 122
SHEET 4 AB711 GLY D 235 ARG D 243 -1 O LEU D 239 N VAL D 193
SHEET 5 AB711 ILE D 5 ARG D 13 -1 N ALA D 6 O LYS D 242
SHEET 6 AB711 GLY D 256 GLN D 265 -1 O ILE D 258 N ILE D 5
SHEET 7 AB711 THR D 415 GLU D 422 -1 O VAL D 420 N GLY D 260
SHEET 8 AB711 ARG D 404 PHE D 410 -1 N ALA D 405 O ILE D 421
SHEET 9 AB711 TYR D 300 GLU D 302 1 N GLU D 302 O CYS D 406
SHEET 10 AB711 CYS D 333 GLY D 336 1 O ALA D 334 N VAL D 301
SHEET 11 AB711 LEU D 386 VAL D 388 1 O TYR D 387 N CYS D 333
SHEET 1 AB8 2 ILE D 34 ASP D 36 0
SHEET 2 AB8 2 SER D 62 GLY D 64 -1 O MET D 63 N ARG D 35
SHEET 1 AB9 2 HIS D 71 PHE D 72 0
SHEET 2 AB9 2 GLU D 586 TYR D 587 -1 O GLU D 586 N PHE D 72
SHEET 1 AC1 2 THR D 365 LEU D 366 0
SHEET 2 AC1 2 LYS D 393 PRO D 394 -1 O LYS D 393 N LEU D 366
SHEET 1 AC2 3 ALA D 440 ALA D 446 0
SHEET 2 AC2 3 TYR D 487 ALA D 493 -1 O PHE D 491 N PHE D 442
SHEET 3 AC2 3 ILE D 515 HIS D 519 -1 O ALA D 518 N ARG D 488
SHEET 1 AC311 ALA E 162 ILE E 165 0
SHEET 2 AC311 CYS E 117 GLY E 122 1 N LEU E 121 O ILE E 165
SHEET 3 AC311 MET E 190 SER E 197 1 O GLY E 194 N GLY E 122
SHEET 4 AC311 GLY E 235 ARG E 243 -1 O LEU E 241 N ALA E 191
SHEET 5 AC311 ILE E 5 ARG E 13 -1 N ALA E 6 O LYS E 242
SHEET 6 AC311 GLY E 256 GLN E 265 -1 O ILE E 258 N ILE E 5
SHEET 7 AC311 THR E 415 GLU E 422 -1 O VAL E 420 N GLY E 260
SHEET 8 AC311 ARG E 404 PHE E 410 -1 N ALA E 405 O ILE E 421
SHEET 9 AC311 TYR E 300 GLU E 302 1 N GLU E 302 O CYS E 406
SHEET 10 AC311 CYS E 333 GLY E 336 1 O ALA E 334 N VAL E 301
SHEET 11 AC311 LEU E 386 VAL E 388 1 O TYR E 387 N ILE E 335
SHEET 1 AC4 2 ARG E 35 ASP E 36 0
SHEET 2 AC4 2 SER E 62 MET E 63 -1 O MET E 63 N ARG E 35
SHEET 1 AC5 2 HIS E 71 PHE E 72 0
SHEET 2 AC5 2 GLU E 586 TYR E 587 -1 O GLU E 586 N PHE E 72
SHEET 1 AC6 2 THR E 365 LEU E 366 0
SHEET 2 AC6 2 LYS E 393 PRO E 394 -1 O LYS E 393 N LEU E 366
SHEET 1 AC7 3 ALA E 440 ALA E 446 0
SHEET 2 AC7 3 TYR E 487 ALA E 493 -1 O PHE E 491 N PHE E 442
SHEET 3 AC7 3 ILE E 515 HIS E 519 -1 O PHE E 516 N ALA E 490
SHEET 1 AC811 ALA F 162 ILE F 165 0
SHEET 2 AC811 CYS F 117 GLY F 122 1 N LEU F 121 O ILE F 165
SHEET 3 AC811 MET F 190 SER F 197 1 O GLY F 194 N GLY F 122
SHEET 4 AC811 GLY F 235 ARG F 243 -1 O LEU F 241 N ALA F 191
SHEET 5 AC811 ILE F 5 ARG F 13 -1 N GLY F 9 O VAL F 240
SHEET 6 AC811 GLY F 256 GLN F 265 -1 O ILE F 258 N ILE F 5
SHEET 7 AC811 THR F 415 GLU F 422 -1 O VAL F 420 N GLY F 260
SHEET 8 AC811 ARG F 404 PHE F 410 -1 N ALA F 405 O ILE F 421
SHEET 9 AC811 TYR F 300 GLU F 302 1 N GLU F 302 O CYS F 406
SHEET 10 AC811 CYS F 333 GLY F 336 1 O ALA F 334 N VAL F 301
SHEET 11 AC811 LEU F 386 VAL F 388 1 O TYR F 387 N ILE F 335
SHEET 1 AC9 2 ILE F 34 ASP F 36 0
SHEET 2 AC9 2 SER F 62 GLY F 64 -1 O MET F 63 N ARG F 35
SHEET 1 AD1 2 HIS F 71 PHE F 72 0
SHEET 2 AD1 2 GLU F 586 TYR F 587 -1 O GLU F 586 N PHE F 72
SHEET 1 AD2 2 THR F 365 LEU F 366 0
SHEET 2 AD2 2 LYS F 393 PRO F 394 -1 O LYS F 393 N LEU F 366
SHEET 1 AD3 3 ALA F 440 ALA F 446 0
SHEET 2 AD3 3 TYR F 487 ALA F 493 -1 O ALA F 493 N ALA F 440
SHEET 3 AD3 3 ILE F 515 HIS F 519 -1 O PHE F 516 N ALA F 490
SHEET 1 AD411 ALA G 162 ILE G 165 0
SHEET 2 AD411 CYS G 117 GLY G 122 1 N LEU G 121 O ILE G 165
SHEET 3 AD411 MET G 190 SER G 197 1 O GLY G 194 N GLY G 122
SHEET 4 AD411 GLY G 235 ARG G 243 -1 O LEU G 239 N VAL G 193
SHEET 5 AD411 ILE G 5 ARG G 13 -1 N GLY G 9 O VAL G 240
SHEET 6 AD411 GLY G 256 GLN G 265 -1 O ILE G 258 N ILE G 5
SHEET 7 AD411 THR G 415 GLU G 422 -1 O ASN G 416 N ASN G 264
SHEET 8 AD411 ARG G 404 PHE G 410 -1 N ALA G 405 O ILE G 421
SHEET 9 AD411 TYR G 300 GLU G 302 1 N GLU G 302 O CYS G 406
SHEET 10 AD411 CYS G 333 GLY G 336 1 O ALA G 334 N VAL G 301
SHEET 11 AD411 LEU G 386 VAL G 388 1 O TYR G 387 N ILE G 335
SHEET 1 AD5 2 ILE G 34 ASP G 36 0
SHEET 2 AD5 2 SER G 62 GLY G 64 -1 O MET G 63 N ARG G 35
SHEET 1 AD6 2 HIS G 71 PHE G 72 0
SHEET 2 AD6 2 GLU G 586 TYR G 587 -1 O GLU G 586 N PHE G 72
SHEET 1 AD7 2 THR G 365 LEU G 366 0
SHEET 2 AD7 2 LYS G 393 PRO G 394 -1 O LYS G 393 N LEU G 366
SHEET 1 AD8 3 ALA G 440 ALA G 446 0
SHEET 2 AD8 3 TYR G 487 ALA G 493 -1 O MET G 489 N LEU G 444
SHEET 3 AD8 3 ILE G 515 HIS G 519 -1 O PHE G 516 N ALA G 490
SHEET 1 AD911 ALA H 162 ILE H 165 0
SHEET 2 AD911 CYS H 117 GLY H 122 1 N LEU H 121 O ILE H 165
SHEET 3 AD911 MET H 190 SER H 197 1 O LEU H 192 N GLY H 118
SHEET 4 AD911 GLY H 235 ARG H 243 -1 O LEU H 239 N VAL H 193
SHEET 5 AD911 ILE H 5 ARG H 13 -1 N GLY H 9 O VAL H 240
SHEET 6 AD911 GLY H 256 GLN H 265 -1 O ILE H 258 N ILE H 5
SHEET 7 AD911 THR H 415 GLU H 422 -1 O VAL H 420 N GLY H 260
SHEET 8 AD911 ARG H 404 PHE H 410 -1 N ALA H 405 O ILE H 421
SHEET 9 AD911 TYR H 300 GLU H 302 1 N GLU H 302 O CYS H 406
SHEET 10 AD911 CYS H 333 GLY H 336 1 O ALA H 334 N VAL H 301
SHEET 11 AD911 LEU H 386 VAL H 388 1 O TYR H 387 N ILE H 335
SHEET 1 AE1 2 ARG H 35 ASP H 36 0
SHEET 2 AE1 2 SER H 62 MET H 63 -1 O MET H 63 N ARG H 35
SHEET 1 AE2 2 HIS H 71 PHE H 72 0
SHEET 2 AE2 2 GLU H 586 TYR H 587 -1 O GLU H 586 N PHE H 72
SHEET 1 AE3 2 THR H 365 LEU H 366 0
SHEET 2 AE3 2 LYS H 393 PRO H 394 -1 O LYS H 393 N LEU H 366
SHEET 1 AE4 3 ALA H 440 ALA H 446 0
SHEET 2 AE4 3 TYR H 487 ALA H 493 -1 O PHE H 491 N PHE H 442
SHEET 3 AE4 3 ILE H 515 HIS H 519 -1 O PHE H 516 N ALA H 490
LINK CA GLY A 271 OE2 GLU F 377 1555 1555 1.50
LINK O TRP B 543 CB LYS B 546 1555 1555 1.39
LINK C GLU C 377 OD1 ASN H 270 1555 1555 1.39
LINK CZ PHE F 530 CD2 LEU G 529 1555 1555 1.46
CISPEP 1 GLU B 545 LYS B 546 0 0.60
CISPEP 2 GLU F 545 LYS F 546 0 -27.54
CRYST1 63.106 112.732 211.441 104.96 90.07 106.32 P 1 8
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.015846 0.004638 0.001316 0.00000
SCALE2 0.000000 0.009243 0.002585 0.00000
SCALE3 0.000000 0.000000 0.004911 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
