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Database: PDB
Entry: 5GJW
LinkDB: 5GJW
Original site: 5GJW 
HEADER    MEMBRANE PROTEIN                        02-JUL-16   5GJW              
TITLE     STRUCTURE OF THE MAMMALIAN VOLTAGE-GATED CALCIUM CHANNEL CAV1.1       
TITLE    2 COMPLEX FOR CLASSII MAP                                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S; 
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: CALCIUM CHANNEL,L TYPE,ALPHA-1 POLYPEPTIDE,ISOFORM 3,       
COMPND   5 SKELETAL MUSCLE,VOLTAGE-GATED CALCIUM CHANNEL SUBUNIT ALPHA CAV1.1;  
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1;   
COMPND   8 CHAIN: B;                                                            
COMPND   9 FRAGMENT: UNP RESIDUES 80-174;                                       
COMPND  10 SYNONYM: CAB1,CALCIUM CHANNEL VOLTAGE-DEPENDENT SUBUNIT BETA 1;      
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1;   
COMPND  14 CHAIN: C;                                                            
COMPND  15 FRAGMENT: UNP RESIDUES 265-463;                                      
COMPND  16 SYNONYM: CAB1,CALCIUM CHANNEL VOLTAGE-DEPENDENT SUBUNIT BETA 1;      
COMPND  17 ENGINEERED: YES;                                                     
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT;         
COMPND  20 CHAIN: E;                                                            
COMPND  21 SYNONYM: DIHYDROPYRIDINE-SENSITIVE L-TYPE,SKELETAL MUSCLE CALCIUM    
COMPND  22 CHANNEL SUBUNIT GAMMA;                                               
COMPND  23 MOL_ID: 5;                                                           
COMPND  24 MOLECULE: VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1; 
COMPND  25 CHAIN: F;                                                            
COMPND  26 SYNONYM: VOLTAGE-GATED CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1       
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE   3 ORGANISM_COMMON: RABBIT;                                             
SOURCE   4 ORGANISM_TAXID: 9986;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE   7 ORGANISM_COMMON: RABBIT;                                             
SOURCE   8 ORGANISM_TAXID: 9986;                                                
SOURCE   9 GENE: CACNB1, CACNLB1;                                               
SOURCE  10 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  11 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  12 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  13 EXPRESSION_SYSTEM_PLASMID: PGEX-4T-2;                                
SOURCE  14 MOL_ID: 3;                                                           
SOURCE  15 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  16 ORGANISM_COMMON: RABBIT;                                             
SOURCE  17 ORGANISM_TAXID: 9986;                                                
SOURCE  18 GENE: CACNB1, CACNLB1;                                               
SOURCE  19 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  20 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  21 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  22 EXPRESSION_SYSTEM_PLASMID: PGEX-4T-2;                                
SOURCE  23 MOL_ID: 4;                                                           
SOURCE  24 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  25 ORGANISM_COMMON: RABBIT;                                             
SOURCE  26 ORGANISM_TAXID: 9986;                                                
SOURCE  27 MOL_ID: 5;                                                           
SOURCE  28 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  29 ORGANISM_COMMON: RABBIT;                                             
SOURCE  30 ORGANISM_TAXID: 9986                                                 
KEYWDS    COMPLEX, CHANNEL, MEMBRANE PROTEIN                                    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.P.WU,Z.YAN,Z.Q.LI,Q.ZHOU,N.YAN                                      
REVDAT   2   21-SEP-16 5GJW    1       JRNL                                     
REVDAT   1   14-SEP-16 5GJW    0                                                
JRNL        AUTH   J.P.WU,Z.YAN,Z.Q.LI,X.Y.QIAN,S.LU,M.Q.DONG,Q.ZHOU,N.YAN      
JRNL        TITL   STRUCTURE OF THE VOLTAGE-GATED CALCIUM CHANNEL CAV1.1 AT 3.6 
JRNL        TITL 2 ANGSTROM RESOLUTION                                          
JRNL        REF    NATURE                        V. 537   191 2016              
JRNL        REFN                   ESSN 1476-4687                               
JRNL        PMID   27580036                                                     
JRNL        DOI    10.1038/NATURE19321                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : RIGID BODY FIT                      
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.900                          
REMARK   3   NUMBER OF PARTICLES               : NULL                           
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5GJW COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 26-AUG-16.                  
REMARK 100 THE DEPOSITION ID IS D_1300000931.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : NULL                              
REMARK 245   PARTICLE TYPE                  : NULL                              
REMARK 245   NAME OF SAMPLE                 : NULL                              
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : GRIDS WERE BLOTTED FOR 2 S AND    
REMARK 245                                    FLASH-FROZEN IN LIQUID ETHANE     
REMARK 245                                    COOLED BY LIQUID NITROGEN         
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : NULL                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : NULL                           
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : NULL                           
REMARK 245   ILLUMINATION MODE                 : SPOT SCAN                      
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, E, F                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLU A     2                                                      
REMARK 465     PRO A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     SER A     5                                                      
REMARK 465     PRO A     6                                                      
REMARK 465     GLN A     7                                                      
REMARK 465     ASP A     8                                                      
REMARK 465     GLU A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     LEU A    11                                                      
REMARK 465     ARG A    12                                                      
REMARK 465     LYS A    13                                                      
REMARK 465     LYS A    14                                                      
REMARK 465     GLN A    15                                                      
REMARK 465     PRO A    16                                                      
REMARK 465     LYS A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     PRO A    19                                                      
REMARK 465     LEU A    20                                                      
REMARK 465     PRO A    21                                                      
REMARK 465     GLU A    22                                                      
REMARK 465     VAL A    23                                                      
REMARK 465     LEU A    24                                                      
REMARK 465     PRO A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     PRO A    28                                                      
REMARK 465     ARG A    29                                                      
REMARK 465     ALA A    30                                                      
REMARK 465     LEU A    31                                                      
REMARK 465     GLU A   140                                                      
REMARK 465     GLN A   141                                                      
REMARK 465     VAL A   142                                                      
REMARK 465     ASN A   143                                                      
REMARK 465     VAL A   144                                                      
REMARK 465     ILE A   145                                                      
REMARK 465     GLN A   146                                                      
REMARK 465     SER A   147                                                      
REMARK 465     ASN A   148                                                      
REMARK 465     THR A   149                                                      
REMARK 465     ALA A   150                                                      
REMARK 465     PRO A   151                                                      
REMARK 465     MET A   152                                                      
REMARK 465     SER A   153                                                      
REMARK 465     SER A   154                                                      
REMARK 465     LYS A   155                                                      
REMARK 465     GLY A   156                                                      
REMARK 465     ALA A   157                                                      
REMARK 465     GLY A   158                                                      
REMARK 465     LEU A   159                                                      
REMARK 465     ASP A   160                                                      
REMARK 465     ASP A   377                                                      
REMARK 465     VAL A   378                                                      
REMARK 465     GLU A   379                                                      
REMARK 465     ASP A   380                                                      
REMARK 465     LEU A   381                                                      
REMARK 465     ARG A   382                                                      
REMARK 465     GLU A   383                                                      
REMARK 465     GLY A   384                                                      
REMARK 465     LYS A   385                                                      
REMARK 465     LEU A   386                                                      
REMARK 465     SER A   387                                                      
REMARK 465     LEU A   388                                                      
REMARK 465     GLU A   389                                                      
REMARK 465     GLU A   390                                                      
REMARK 465     GLY A   391                                                      
REMARK 465     GLY A   392                                                      
REMARK 465     SER A   393                                                      
REMARK 465     ASP A   394                                                      
REMARK 465     THR A   395                                                      
REMARK 465     GLU A   396                                                      
REMARK 465     SER A   397                                                      
REMARK 465     LEU A   398                                                      
REMARK 465     TYR A   399                                                      
REMARK 465     GLU A   400                                                      
REMARK 465     ILE A   401                                                      
REMARK 465     GLU A   402                                                      
REMARK 465     GLY A   403                                                      
REMARK 465     LEU A   404                                                      
REMARK 465     ASN A   405                                                      
REMARK 465     LYS A   406                                                      
REMARK 465     ILE A   407                                                      
REMARK 465     ILE A   408                                                      
REMARK 465     GLN A   409                                                      
REMARK 465     PHE A   410                                                      
REMARK 465     ILE A   411                                                      
REMARK 465     ARG A   412                                                      
REMARK 465     HIS A   413                                                      
REMARK 465     TRP A   414                                                      
REMARK 465     ARG A   415                                                      
REMARK 465     GLN A   416                                                      
REMARK 465     TRP A   417                                                      
REMARK 465     SER A   687                                                      
REMARK 465     ARG A   688                                                      
REMARK 465     GLY A   689                                                      
REMARK 465     LEU A   690                                                      
REMARK 465     PRO A   691                                                      
REMARK 465     ASP A   692                                                      
REMARK 465     LYS A   693                                                      
REMARK 465     THR A   694                                                      
REMARK 465     GLU A   695                                                      
REMARK 465     GLU A   696                                                      
REMARK 465     GLU A   697                                                      
REMARK 465     LYS A   698                                                      
REMARK 465     SER A   699                                                      
REMARK 465     VAL A   700                                                      
REMARK 465     MET A   701                                                      
REMARK 465     ALA A   702                                                      
REMARK 465     LYS A   703                                                      
REMARK 465     LYS A   704                                                      
REMARK 465     LEU A   705                                                      
REMARK 465     GLU A   706                                                      
REMARK 465     GLN A   707                                                      
REMARK 465     LYS A   708                                                      
REMARK 465     PRO A   709                                                      
REMARK 465     LYS A   710                                                      
REMARK 465     GLY A   711                                                      
REMARK 465     GLU A   712                                                      
REMARK 465     GLY A   713                                                      
REMARK 465     ILE A   714                                                      
REMARK 465     PRO A   715                                                      
REMARK 465     THR A   716                                                      
REMARK 465     THR A   717                                                      
REMARK 465     ALA A   718                                                      
REMARK 465     LYS A   719                                                      
REMARK 465     LEU A   720                                                      
REMARK 465     LYS A   721                                                      
REMARK 465     VAL A   722                                                      
REMARK 465     ASP A   723                                                      
REMARK 465     GLU A   724                                                      
REMARK 465     PHE A   725                                                      
REMARK 465     GLU A   726                                                      
REMARK 465     SER A   727                                                      
REMARK 465     ASN A   728                                                      
REMARK 465     VAL A   729                                                      
REMARK 465     ASN A   730                                                      
REMARK 465     GLU A   731                                                      
REMARK 465     VAL A   732                                                      
REMARK 465     LYS A   733                                                      
REMARK 465     ASP A   734                                                      
REMARK 465     PRO A   735                                                      
REMARK 465     TYR A   736                                                      
REMARK 465     PRO A   737                                                      
REMARK 465     SER A   738                                                      
REMARK 465     ALA A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     PHE A   741                                                      
REMARK 465     PRO A   742                                                      
REMARK 465     GLY A   743                                                      
REMARK 465     ASP A   744                                                      
REMARK 465     ASP A   745                                                      
REMARK 465     GLU A   746                                                      
REMARK 465     GLU A   747                                                      
REMARK 465     ASP A   748                                                      
REMARK 465     GLU A   749                                                      
REMARK 465     PRO A   750                                                      
REMARK 465     GLU A   751                                                      
REMARK 465     ILE A   752                                                      
REMARK 465     PRO A   753                                                      
REMARK 465     VAL A   754                                                      
REMARK 465     SER A   755                                                      
REMARK 465     PRO A   756                                                      
REMARK 465     ARG A   757                                                      
REMARK 465     PRO A   758                                                      
REMARK 465     ARG A   759                                                      
REMARK 465     PRO A   760                                                      
REMARK 465     LEU A   761                                                      
REMARK 465     ALA A   762                                                      
REMARK 465     GLU A   763                                                      
REMARK 465     LEU A   764                                                      
REMARK 465     GLN A   765                                                      
REMARK 465     LEU A   766                                                      
REMARK 465     LYS A   767                                                      
REMARK 465     GLU A   768                                                      
REMARK 465     LYS A   769                                                      
REMARK 465     ALA A   770                                                      
REMARK 465     VAL A   771                                                      
REMARK 465     PRO A   772                                                      
REMARK 465     ILE A   773                                                      
REMARK 465     PRO A   774                                                      
REMARK 465     GLU A   775                                                      
REMARK 465     ALA A   776                                                      
REMARK 465     SER A   777                                                      
REMARK 465     SER A   778                                                      
REMARK 465     PHE A   779                                                      
REMARK 465     PHE A   780                                                      
REMARK 465     ILE A   781                                                      
REMARK 465     PHE A   782                                                      
REMARK 465     SER A   783                                                      
REMARK 465     PRO A   784                                                      
REMARK 465     THR A   785                                                      
REMARK 465     ASN A   786                                                      
REMARK 465     LYS A   787                                                      
REMARK 465     LEU A   885                                                      
REMARK 465     GLU A   886                                                      
REMARK 465     SER A   887                                                      
REMARK 465     SER A   888                                                      
REMARK 465     THR A   889                                                      
REMARK 465     ILE A   890                                                      
REMARK 465     SER A   891                                                      
REMARK 465     LEU A  1206                                                      
REMARK 465     ALA A  1207                                                      
REMARK 465     SER A  1208                                                      
REMARK 465     SER A  1209                                                      
REMARK 465     GLY A  1210                                                      
REMARK 465     GLY A  1211                                                      
REMARK 465     LEU A  1212                                                      
REMARK 465     TYR A  1213                                                      
REMARK 465     CYS A  1214                                                      
REMARK 465     LEU A  1215                                                      
REMARK 465     GLY A  1216                                                      
REMARK 465     GLY A  1217                                                      
REMARK 465     GLY A  1218                                                      
REMARK 465     CYS A  1219                                                      
REMARK 465     GLY A  1220                                                      
REMARK 465     ASN A  1221                                                      
REMARK 465     VAL A  1222                                                      
REMARK 465     ASP A  1223                                                      
REMARK 465     PRO A  1224                                                      
REMARK 465     ASP A  1225                                                      
REMARK 465     GLU A  1226                                                      
REMARK 465     SER A  1227                                                      
REMARK 465     ALA A  1228                                                      
REMARK 465     ASP A  1516                                                      
REMARK 465     GLU A  1517                                                      
REMARK 465     VAL A  1518                                                      
REMARK 465     THR A  1519                                                      
REMARK 465     VAL A  1520                                                      
REMARK 465     GLY A  1521                                                      
REMARK 465     LYS A  1522                                                      
REMARK 465     PHE A  1523                                                      
REMARK 465     TYR A  1524                                                      
REMARK 465     ALA A  1525                                                      
REMARK 465     THR A  1526                                                      
REMARK 465     PHE A  1527                                                      
REMARK 465     LEU A  1528                                                      
REMARK 465     ILE A  1529                                                      
REMARK 465     GLN A  1530                                                      
REMARK 465     GLU A  1531                                                      
REMARK 465     HIS A  1532                                                      
REMARK 465     PHE A  1533                                                      
REMARK 465     ARG A  1534                                                      
REMARK 465     LYS A  1535                                                      
REMARK 465     PHE A  1536                                                      
REMARK 465     MET A  1537                                                      
REMARK 465     LYS A  1538                                                      
REMARK 465     ARG A  1539                                                      
REMARK 465     GLN A  1540                                                      
REMARK 465     GLU A  1541                                                      
REMARK 465     GLU A  1542                                                      
REMARK 465     TYR A  1543                                                      
REMARK 465     TYR A  1544                                                      
REMARK 465     GLY A  1545                                                      
REMARK 465     TYR A  1546                                                      
REMARK 465     ARG A  1547                                                      
REMARK 465     PRO A  1548                                                      
REMARK 465     LYS A  1549                                                      
REMARK 465     LYS A  1550                                                      
REMARK 465     ASP A  1551                                                      
REMARK 465     THR A  1552                                                      
REMARK 465     VAL A  1553                                                      
REMARK 465     GLN A  1554                                                      
REMARK 465     ILE A  1555                                                      
REMARK 465     GLN A  1556                                                      
REMARK 465     ALA A  1557                                                      
REMARK 465     GLY A  1558                                                      
REMARK 465     LEU A  1559                                                      
REMARK 465     ARG A  1560                                                      
REMARK 465     THR A  1561                                                      
REMARK 465     ILE A  1562                                                      
REMARK 465     GLU A  1563                                                      
REMARK 465     GLU A  1564                                                      
REMARK 465     GLU A  1565                                                      
REMARK 465     ALA A  1566                                                      
REMARK 465     ALA A  1567                                                      
REMARK 465     PRO A  1568                                                      
REMARK 465     GLU A  1569                                                      
REMARK 465     ILE A  1570                                                      
REMARK 465     ARG A  1571                                                      
REMARK 465     ARG A  1572                                                      
REMARK 465     THR A  1573                                                      
REMARK 465     ILE A  1574                                                      
REMARK 465     SER A  1575                                                      
REMARK 465     GLY A  1576                                                      
REMARK 465     ASP A  1577                                                      
REMARK 465     LEU A  1578                                                      
REMARK 465     THR A  1579                                                      
REMARK 465     ALA A  1580                                                      
REMARK 465     GLU A  1581                                                      
REMARK 465     GLU A  1582                                                      
REMARK 465     GLU A  1583                                                      
REMARK 465     LEU A  1584                                                      
REMARK 465     GLU A  1585                                                      
REMARK 465     ARG A  1586                                                      
REMARK 465     ALA A  1587                                                      
REMARK 465     MET A  1588                                                      
REMARK 465     VAL A  1589                                                      
REMARK 465     GLU A  1590                                                      
REMARK 465     ALA A  1591                                                      
REMARK 465     ALA A  1592                                                      
REMARK 465     MET A  1593                                                      
REMARK 465     GLU A  1594                                                      
REMARK 465     GLU A  1595                                                      
REMARK 465     ARG A  1596                                                      
REMARK 465     ILE A  1597                                                      
REMARK 465     PHE A  1598                                                      
REMARK 465     ARG A  1599                                                      
REMARK 465     ARG A  1600                                                      
REMARK 465     THR A  1601                                                      
REMARK 465     GLY A  1602                                                      
REMARK 465     GLY A  1603                                                      
REMARK 465     LEU A  1604                                                      
REMARK 465     PHE A  1605                                                      
REMARK 465     GLY A  1606                                                      
REMARK 465     GLN A  1607                                                      
REMARK 465     VAL A  1608                                                      
REMARK 465     ASP A  1609                                                      
REMARK 465     THR A  1610                                                      
REMARK 465     PHE A  1611                                                      
REMARK 465     LEU A  1612                                                      
REMARK 465     GLU A  1613                                                      
REMARK 465     ARG A  1614                                                      
REMARK 465     THR A  1615                                                      
REMARK 465     ASN A  1616                                                      
REMARK 465     SER A  1617                                                      
REMARK 465     LEU A  1618                                                      
REMARK 465     PRO A  1619                                                      
REMARK 465     PRO A  1620                                                      
REMARK 465     VAL A  1621                                                      
REMARK 465     MET A  1622                                                      
REMARK 465     ALA A  1623                                                      
REMARK 465     ASN A  1624                                                      
REMARK 465     GLN A  1625                                                      
REMARK 465     ARG A  1626                                                      
REMARK 465     PRO A  1627                                                      
REMARK 465     LEU A  1628                                                      
REMARK 465     GLN A  1629                                                      
REMARK 465     PHE A  1630                                                      
REMARK 465     ALA A  1631                                                      
REMARK 465     GLU A  1632                                                      
REMARK 465     ILE A  1633                                                      
REMARK 465     GLU A  1634                                                      
REMARK 465     MET A  1635                                                      
REMARK 465     GLU A  1636                                                      
REMARK 465     GLU A  1637                                                      
REMARK 465     LEU A  1638                                                      
REMARK 465     GLU A  1639                                                      
REMARK 465     SER A  1640                                                      
REMARK 465     PRO A  1641                                                      
REMARK 465     VAL A  1642                                                      
REMARK 465     PHE A  1643                                                      
REMARK 465     LEU A  1644                                                      
REMARK 465     GLU A  1645                                                      
REMARK 465     ASP A  1646                                                      
REMARK 465     PHE A  1647                                                      
REMARK 465     PRO A  1648                                                      
REMARK 465     GLN A  1649                                                      
REMARK 465     ASP A  1650                                                      
REMARK 465     ALA A  1651                                                      
REMARK 465     ARG A  1652                                                      
REMARK 465     THR A  1653                                                      
REMARK 465     ASN A  1654                                                      
REMARK 465     PRO A  1655                                                      
REMARK 465     LEU A  1656                                                      
REMARK 465     ALA A  1657                                                      
REMARK 465     ARG A  1658                                                      
REMARK 465     ALA A  1659                                                      
REMARK 465     ASN A  1660                                                      
REMARK 465     THR A  1661                                                      
REMARK 465     ASN A  1662                                                      
REMARK 465     ASN A  1663                                                      
REMARK 465     ALA A  1664                                                      
REMARK 465     ASN A  1665                                                      
REMARK 465     ALA A  1666                                                      
REMARK 465     ASN A  1667                                                      
REMARK 465     VAL A  1668                                                      
REMARK 465     ALA A  1669                                                      
REMARK 465     TYR A  1670                                                      
REMARK 465     GLY A  1671                                                      
REMARK 465     ASN A  1672                                                      
REMARK 465     SER A  1673                                                      
REMARK 465     ASN A  1674                                                      
REMARK 465     HIS A  1675                                                      
REMARK 465     SER A  1676                                                      
REMARK 465     ASN A  1677                                                      
REMARK 465     ASN A  1678                                                      
REMARK 465     GLN A  1679                                                      
REMARK 465     MET A  1680                                                      
REMARK 465     PHE A  1681                                                      
REMARK 465     SER A  1682                                                      
REMARK 465     SER A  1683                                                      
REMARK 465     VAL A  1684                                                      
REMARK 465     HIS A  1685                                                      
REMARK 465     CYS A  1686                                                      
REMARK 465     GLU A  1687                                                      
REMARK 465     ARG A  1688                                                      
REMARK 465     GLU A  1689                                                      
REMARK 465     PHE A  1690                                                      
REMARK 465     PRO A  1691                                                      
REMARK 465     GLY A  1692                                                      
REMARK 465     GLU A  1693                                                      
REMARK 465     ALA A  1694                                                      
REMARK 465     GLU A  1695                                                      
REMARK 465     THR A  1696                                                      
REMARK 465     PRO A  1697                                                      
REMARK 465     ALA A  1698                                                      
REMARK 465     ALA A  1699                                                      
REMARK 465     GLY A  1700                                                      
REMARK 465     ARG A  1701                                                      
REMARK 465     GLY A  1702                                                      
REMARK 465     ALA A  1703                                                      
REMARK 465     LEU A  1704                                                      
REMARK 465     SER A  1705                                                      
REMARK 465     HIS A  1706                                                      
REMARK 465     SER A  1707                                                      
REMARK 465     HIS A  1708                                                      
REMARK 465     ARG A  1709                                                      
REMARK 465     ALA A  1710                                                      
REMARK 465     LEU A  1711                                                      
REMARK 465     GLY A  1712                                                      
REMARK 465     PRO A  1713                                                      
REMARK 465     HIS A  1714                                                      
REMARK 465     SER A  1715                                                      
REMARK 465     LYS A  1716                                                      
REMARK 465     PRO A  1717                                                      
REMARK 465     CYS A  1718                                                      
REMARK 465     ALA A  1719                                                      
REMARK 465     GLY A  1720                                                      
REMARK 465     LYS A  1721                                                      
REMARK 465     LEU A  1722                                                      
REMARK 465     ASN A  1723                                                      
REMARK 465     GLY A  1724                                                      
REMARK 465     GLN A  1725                                                      
REMARK 465     LEU A  1726                                                      
REMARK 465     VAL A  1727                                                      
REMARK 465     GLN A  1728                                                      
REMARK 465     PRO A  1729                                                      
REMARK 465     GLY A  1730                                                      
REMARK 465     MET A  1731                                                      
REMARK 465     PRO A  1732                                                      
REMARK 465     ILE A  1733                                                      
REMARK 465     ASN A  1734                                                      
REMARK 465     GLN A  1735                                                      
REMARK 465     ALA A  1736                                                      
REMARK 465     PRO A  1737                                                      
REMARK 465     PRO A  1738                                                      
REMARK 465     ALA A  1739                                                      
REMARK 465     PRO A  1740                                                      
REMARK 465     CYS A  1741                                                      
REMARK 465     GLN A  1742                                                      
REMARK 465     GLN A  1743                                                      
REMARK 465     PRO A  1744                                                      
REMARK 465     SER A  1745                                                      
REMARK 465     THR A  1746                                                      
REMARK 465     ASP A  1747                                                      
REMARK 465     PRO A  1748                                                      
REMARK 465     PRO A  1749                                                      
REMARK 465     GLU A  1750                                                      
REMARK 465     ARG A  1751                                                      
REMARK 465     GLY A  1752                                                      
REMARK 465     GLN A  1753                                                      
REMARK 465     ARG A  1754                                                      
REMARK 465     ARG A  1755                                                      
REMARK 465     THR A  1756                                                      
REMARK 465     SER A  1757                                                      
REMARK 465     LEU A  1758                                                      
REMARK 465     THR A  1759                                                      
REMARK 465     GLY A  1760                                                      
REMARK 465     SER A  1761                                                      
REMARK 465     LEU A  1762                                                      
REMARK 465     GLN A  1763                                                      
REMARK 465     ASP A  1764                                                      
REMARK 465     GLU A  1765                                                      
REMARK 465     ALA A  1766                                                      
REMARK 465     PRO A  1767                                                      
REMARK 465     GLN A  1768                                                      
REMARK 465     ARG A  1769                                                      
REMARK 465     ARG A  1770                                                      
REMARK 465     SER A  1771                                                      
REMARK 465     SER A  1772                                                      
REMARK 465     GLU A  1773                                                      
REMARK 465     GLY A  1774                                                      
REMARK 465     SER A  1775                                                      
REMARK 465     THR A  1776                                                      
REMARK 465     PRO A  1777                                                      
REMARK 465     ARG A  1778                                                      
REMARK 465     ARG A  1779                                                      
REMARK 465     PRO A  1780                                                      
REMARK 465     ALA A  1781                                                      
REMARK 465     PRO A  1782                                                      
REMARK 465     ALA A  1783                                                      
REMARK 465     THR A  1784                                                      
REMARK 465     ALA A  1785                                                      
REMARK 465     LEU A  1786                                                      
REMARK 465     LEU A  1787                                                      
REMARK 465     ILE A  1788                                                      
REMARK 465     GLN A  1789                                                      
REMARK 465     GLU A  1790                                                      
REMARK 465     ALA A  1791                                                      
REMARK 465     LEU A  1792                                                      
REMARK 465     VAL A  1793                                                      
REMARK 465     ARG A  1794                                                      
REMARK 465     GLY A  1795                                                      
REMARK 465     GLY A  1796                                                      
REMARK 465     LEU A  1797                                                      
REMARK 465     ASP A  1798                                                      
REMARK 465     THR A  1799                                                      
REMARK 465     LEU A  1800                                                      
REMARK 465     ALA A  1801                                                      
REMARK 465     ALA A  1802                                                      
REMARK 465     ASP A  1803                                                      
REMARK 465     ALA A  1804                                                      
REMARK 465     GLY A  1805                                                      
REMARK 465     PHE A  1806                                                      
REMARK 465     VAL A  1807                                                      
REMARK 465     THR A  1808                                                      
REMARK 465     ALA A  1809                                                      
REMARK 465     THR A  1810                                                      
REMARK 465     SER A  1811                                                      
REMARK 465     GLN A  1812                                                      
REMARK 465     ALA A  1813                                                      
REMARK 465     LEU A  1814                                                      
REMARK 465     ALA A  1815                                                      
REMARK 465     ASP A  1816                                                      
REMARK 465     ALA A  1817                                                      
REMARK 465     CYS A  1818                                                      
REMARK 465     GLN A  1819                                                      
REMARK 465     MET A  1820                                                      
REMARK 465     GLU A  1821                                                      
REMARK 465     PRO A  1822                                                      
REMARK 465     GLU A  1823                                                      
REMARK 465     GLU A  1824                                                      
REMARK 465     VAL A  1825                                                      
REMARK 465     GLU A  1826                                                      
REMARK 465     VAL A  1827                                                      
REMARK 465     ALA A  1828                                                      
REMARK 465     ALA A  1829                                                      
REMARK 465     THR A  1830                                                      
REMARK 465     GLU A  1831                                                      
REMARK 465     LEU A  1832                                                      
REMARK 465     LEU A  1833                                                      
REMARK 465     LYS A  1834                                                      
REMARK 465     ALA A  1835                                                      
REMARK 465     ARG A  1836                                                      
REMARK 465     GLU A  1837                                                      
REMARK 465     SER A  1838                                                      
REMARK 465     VAL A  1839                                                      
REMARK 465     GLN A  1840                                                      
REMARK 465     GLY A  1841                                                      
REMARK 465     MET A  1842                                                      
REMARK 465     ALA A  1843                                                      
REMARK 465     SER A  1844                                                      
REMARK 465     VAL A  1845                                                      
REMARK 465     PRO A  1846                                                      
REMARK 465     GLY A  1847                                                      
REMARK 465     SER A  1848                                                      
REMARK 465     LEU A  1849                                                      
REMARK 465     SER A  1850                                                      
REMARK 465     ARG A  1851                                                      
REMARK 465     ARG A  1852                                                      
REMARK 465     SER A  1853                                                      
REMARK 465     SER A  1854                                                      
REMARK 465     LEU A  1855                                                      
REMARK 465     GLY A  1856                                                      
REMARK 465     SER A  1857                                                      
REMARK 465     LEU A  1858                                                      
REMARK 465     ASP A  1859                                                      
REMARK 465     GLN A  1860                                                      
REMARK 465     VAL A  1861                                                      
REMARK 465     GLN A  1862                                                      
REMARK 465     GLY A  1863                                                      
REMARK 465     SER A  1864                                                      
REMARK 465     GLN A  1865                                                      
REMARK 465     GLU A  1866                                                      
REMARK 465     THR A  1867                                                      
REMARK 465     LEU A  1868                                                      
REMARK 465     ILE A  1869                                                      
REMARK 465     PRO A  1870                                                      
REMARK 465     PRO A  1871                                                      
REMARK 465     ARG A  1872                                                      
REMARK 465     PRO A  1873                                                      
REMARK 465     SER B    69                                                      
REMARK 465     LEU B    70                                                      
REMARK 465     GLU B    71                                                      
REMARK 465     VAL B    72                                                      
REMARK 465     LEU B    73                                                      
REMARK 465     PHE B    74                                                      
REMARK 465     LYS C   322                                                      
REMARK 465     ARG C   323                                                      
REMARK 465     SER C   324                                                      
REMARK 465     VAL C   325                                                      
REMARK 465     LEU C   326                                                      
REMARK 465     ASN C   327                                                      
REMARK 465     ASN C   328                                                      
REMARK 465     PRO C   329                                                      
REMARK 465     SER C   330                                                      
REMARK 465     LYS C   331                                                      
REMARK 465     HIS C   332                                                      
REMARK 465     ILE C   333                                                      
REMARK 465     ILE C   334                                                      
REMARK 465     ILE C   335                                                      
REMARK 465     GLU C   336                                                      
REMARK 465     ARG C   337                                                      
REMARK 465     SER C   338                                                      
REMARK 465     ASN C   339                                                      
REMARK 465     THR C   340                                                      
REMARK 465     SER C   462                                                      
REMARK 465     THR C   463                                                      
REMARK 465     MET E    39                                                      
REMARK 465     GLU E    40                                                      
REMARK 465     ASN E    41                                                      
REMARK 465     HIS E    42                                                      
REMARK 465     ASN E    43                                                      
REMARK 465     THR E    44                                                      
REMARK 465     THR E    45                                                      
REMARK 465     ILE E    61                                                      
REMARK 465     ALA E    62                                                      
REMARK 465     LEU E    63                                                      
REMARK 465     GLY E    64                                                      
REMARK 465     GLU E    65                                                      
REMARK 465     ASP E    66                                                      
REMARK 465     ARG E    67                                                      
REMARK 465     SER E    68                                                      
REMARK 465     CYS E    69                                                      
REMARK 465     GLY E    70                                                      
REMARK 465     PRO E    71                                                      
REMARK 465     ILE E    72                                                      
REMARK 465     THR E    73                                                      
REMARK 465     LEU E    74                                                      
REMARK 465     PRO E    75                                                      
REMARK 465     ARG E    84                                                      
REMARK 465     HIS E    85                                                      
REMARK 465     PHE E    86                                                      
REMARK 465     ASN E    87                                                      
REMARK 465     PRO E    88                                                      
REMARK 465     GLY E    89                                                      
REMARK 465     GLU E    90                                                      
REMARK 465     SER E    91                                                      
REMARK 465     SER E    92                                                      
REMARK 465     GLU E    93                                                      
REMARK 465     ILE E    94                                                      
REMARK 465     PHE E    95                                                      
REMARK 465     GLU E    96                                                      
REMARK 465     PHE E    97                                                      
REMARK 465     THR E    98                                                      
REMARK 465     THR E    99                                                      
REMARK 465     GLN E   100                                                      
REMARK 465     LYS E   101                                                      
REMARK 465     GLU E   102                                                      
REMARK 465     TYR E   103                                                      
REMARK 465     ILE E   166                                                      
REMARK 465     ASP E   167                                                      
REMARK 465     SER E   168                                                      
REMARK 465     GLU E   169                                                      
REMARK 465     ASP E   170                                                      
REMARK 465     THR E   171                                                      
REMARK 465     VAL E   172                                                      
REMARK 465     TRP E   173                                                      
REMARK 465     ASP E   217                                                      
REMARK 465     ALA E   218                                                      
REMARK 465     GLU E   219                                                      
REMARK 465     PRO E   220                                                      
REMARK 465     GLU E   221                                                      
REMARK 465     HIS E   222                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     ALA F     3                                                      
REMARK 465     GLY F     4                                                      
REMARK 465     ARG F     5                                                      
REMARK 465     PRO F     6                                                      
REMARK 465     LEU F     7                                                      
REMARK 465     ALA F     8                                                      
REMARK 465     TRP F     9                                                      
REMARK 465     THR F    10                                                      
REMARK 465     LEU F    11                                                      
REMARK 465     THR F    12                                                      
REMARK 465     LEU F    13                                                      
REMARK 465     TRP F    14                                                      
REMARK 465     GLN F    15                                                      
REMARK 465     ALA F    16                                                      
REMARK 465     TRP F    17                                                      
REMARK 465     LEU F    18                                                      
REMARK 465     ILE F    19                                                      
REMARK 465     LEU F    20                                                      
REMARK 465     ILE F    21                                                      
REMARK 465     GLY F    22                                                      
REMARK 465     PRO F    23                                                      
REMARK 465     SER F    24                                                      
REMARK 465     SER F    25                                                      
REMARK 465     GLU F    26                                                      
REMARK 465     GLU F    27                                                      
REMARK 465     PRO F    28                                                      
REMARK 465     ASN F   124                                                      
REMARK 465     GLU F   125                                                      
REMARK 465     ASP F   133A                                                     
REMARK 465     LEU F   133B                                                     
REMARK 465     ASP F   133C                                                     
REMARK 465     PRO F   133D                                                     
REMARK 465     GLU F   133E                                                     
REMARK 465     LYS F   133F                                                     
REMARK 465     ASN F   133G                                                     
REMARK 465     ASP F   133H                                                     
REMARK 465     SER F   133I                                                     
REMARK 465     GLU F   133J                                                     
REMARK 465     PRO F   133K                                                     
REMARK 465     GLY F   133L                                                     
REMARK 465     SER F   133M                                                     
REMARK 465     ASP F   227                                                      
REMARK 465     ASN F   228                                                      
REMARK 465     SER F   229                                                      
REMARK 465     ARG F   230                                                      
REMARK 465     THR F   231                                                      
REMARK 465     PRO F   232                                                      
REMARK 465     ASN F   233                                                      
REMARK 465     PRO F   695                                                      
REMARK 465     ASN F   696                                                      
REMARK 465     ASN F   697                                                      
REMARK 465     PRO F   698                                                      
REMARK 465     SER F   699                                                      
REMARK 465     CYS F   700                                                      
REMARK 465     ASN F   701                                                      
REMARK 465     ASP F   835                                                      
REMARK 465     PRO F   836                                                      
REMARK 465     CYS F   837                                                      
REMARK 465     ALA F   838                                                      
REMARK 465     GLY F   839                                                      
REMARK 465     PRO F   840                                                      
REMARK 465     VAL F   841                                                      
REMARK 465     CYS F   842                                                      
REMARK 465     ASP F   843                                                      
REMARK 465     CYS F   844                                                      
REMARK 465     LYS F   845                                                      
REMARK 465     ARG F   846                                                      
REMARK 465     ASN F   847                                                      
REMARK 465     SER F   848                                                      
REMARK 465     ASP F   849                                                      
REMARK 465     VAL F   850                                                      
REMARK 465     PRO F   913                                                      
REMARK 465     LYS F   914                                                      
REMARK 465     GLN F   915                                                      
REMARK 465     GLY F   916                                                      
REMARK 465     ALA F   917                                                      
REMARK 465     GLY F   918                                                      
REMARK 465     HIS F   919                                                      
REMARK 465     ARG F   920                                                      
REMARK 465     SER F   921                                                      
REMARK 465     ALA F   922                                                      
REMARK 465     TYR F   923                                                      
REMARK 465     VAL F   924                                                      
REMARK 465     PRO F   925                                                      
REMARK 465     SER F   926                                                      
REMARK 465     ILE F   927                                                      
REMARK 465     ALA F   928                                                      
REMARK 465     ASP F   929                                                      
REMARK 465     ILE F   930                                                      
REMARK 465     LEU F   931                                                      
REMARK 465     GLN F   932                                                      
REMARK 465     ILE F   933                                                      
REMARK 465     GLY F   934                                                      
REMARK 465     TRP F   935                                                      
REMARK 465     TRP F   936                                                      
REMARK 465     ALA F   937                                                      
REMARK 465     THR F   938                                                      
REMARK 465     ALA F   939                                                      
REMARK 465     ALA F   940                                                      
REMARK 465     ALA F   941                                                      
REMARK 465     TRP F   942                                                      
REMARK 465     SER F   943                                                      
REMARK 465     ILE F   944                                                      
REMARK 465     LEU F   945                                                      
REMARK 465     GLN F   946                                                      
REMARK 465     GLN F   947                                                      
REMARK 465     PHE F   948                                                      
REMARK 465     LEU F   949                                                      
REMARK 465     LEU F   950                                                      
REMARK 465     SER F   951                                                      
REMARK 465     LEU F   952                                                      
REMARK 465     THR F   953                                                      
REMARK 465     PHE F   954                                                      
REMARK 465     PRO F   955                                                      
REMARK 465     ARG F   956                                                      
REMARK 465     LEU F   957                                                      
REMARK 465     LEU F   958                                                      
REMARK 465     GLU F   959                                                      
REMARK 465     ALA F   960                                                      
REMARK 465     ALA F   961                                                      
REMARK 465     ASP F   962                                                      
REMARK 465     MET F   963                                                      
REMARK 465     GLU F   964                                                      
REMARK 465     ASP F   965                                                      
REMARK 465     ASP F   966                                                      
REMARK 465     ASP F   967                                                      
REMARK 465     PHE F   968                                                      
REMARK 465     THR F   969                                                      
REMARK 465     ALA F   970                                                      
REMARK 465     SER F   971                                                      
REMARK 465     MET F   972                                                      
REMARK 465     GLY F  1076                                                      
REMARK 465     VAL F  1077                                                      
REMARK 465     SER F  1078                                                      
REMARK 465     GLY F  1079                                                      
REMARK 465     LEU F  1080                                                      
REMARK 465     ASN F  1081                                                      
REMARK 465     PRO F  1082                                                      
REMARK 465     SER F  1083                                                      
REMARK 465     LEU F  1084                                                      
REMARK 465     TRP F  1085                                                      
REMARK 465     SER F  1086                                                      
REMARK 465     ILE F  1087                                                      
REMARK 465     ILE F  1088                                                      
REMARK 465     GLY F  1089                                                      
REMARK 465     ILE F  1090                                                      
REMARK 465     GLN F  1091                                                      
REMARK 465     PHE F  1092                                                      
REMARK 465     VAL F  1093                                                      
REMARK 465     LEU F  1094                                                      
REMARK 465     LEU F  1095                                                      
REMARK 465     TRP F  1096                                                      
REMARK 465     LEU F  1097                                                      
REMARK 465     VAL F  1098                                                      
REMARK 465     SER F  1099                                                      
REMARK 465     GLY F  1100                                                      
REMARK 465     SER F  1101                                                      
REMARK 465     ARG F  1102                                                      
REMARK 465     HIS F  1103                                                      
REMARK 465     CYS F  1104                                                      
REMARK 465     LEU F  1105                                                      
REMARK 465     LEU F  1106                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     SER A 862    OG                                                  
REMARK 470     PHE A 863    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     CYS A 864    SG                                                  
REMARK 470     ARG A 865    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN A 866    CG   OD1  ND2                                       
REMARK 470     TYR A 867    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE A 868    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN A 869    CG   OD1  ND2                                       
REMARK 470     ILE A 870    CG1  CG2  CD1                                       
REMARK 470     LEU A 871    CG   CD1  CD2                                       
REMARK 470     ASP A 872    CG   OD1  OD2                                       
REMARK 470     LEU A 873    CG   CD1  CD2                                       
REMARK 470     LEU A 874    CG   CD1  CD2                                       
REMARK 470     VAL A 875    CG1  CG2                                            
REMARK 470     VAL A 876    CG1  CG2                                            
REMARK 470     VAL A 878    CG1  CG2                                            
REMARK 470     SER A 879    OG                                                  
REMARK 470     LEU A 880    CG   CD1  CD2                                       
REMARK 470     ILE A 881    CG1  CG2  CD1                                       
REMARK 470     SER A 882    OG                                                  
REMARK 470     MET A 883    CG   SD   CE                                        
REMARK 470     LEU A1475    CG   CD1  CD2                                       
REMARK 470     LYS A1476    CG   CD   CE   NZ                                   
REMARK 470     ILE A1477    CG1  CG2  CD1                                       
REMARK 470     LYS A1478    CG   CD   CE   NZ                                   
REMARK 470     THR A1479    OG1  CG2                                            
REMARK 470     GLU A1480    CG   CD   OE1  OE2                                  
REMARK 470     ASN A1482    CG   OD1  ND2                                       
REMARK 470     PHE A1483    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A1484    CG   CD   OE1  OE2                                  
REMARK 470     GLN A1485    CG   CD   OE1  NE2                                  
REMARK 470     ASN A1487    CG   OD1  ND2                                       
REMARK 470     GLU A1488    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1489    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1490    CG   CD1  CD2                                       
REMARK 470     ARG A1491    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE A1493    CG1  CG2  CD1                                       
REMARK 470     ILE A1494    CG1  CG2  CD1                                       
REMARK 470     LYS A1495    CG   CD   CE   NZ                                   
REMARK 470     LYS A1496    CG   CD   CE   NZ                                   
REMARK 470     ILE A1497    CG1  CG2  CD1                                       
REMARK 470     TRP A1498    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP A1498    CZ3  CH2                                            
REMARK 470     LYS A1499    CG   CD   CE   NZ                                   
REMARK 470     ARG A1500    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR A1501    OG1  CG2                                            
REMARK 470     SER A1502    OG                                                  
REMARK 470     MET A1503    CG   SD   CE                                        
REMARK 470     LYS A1504    CG   CD   CE   NZ                                   
REMARK 470     LEU A1505    CG   CD1  CD2                                       
REMARK 470     LEU A1506    CG   CD1  CD2                                       
REMARK 470     ASP A1507    CG   OD1  OD2                                       
REMARK 470     GLN A1508    CG   CD   OE1  NE2                                  
REMARK 470     VAL A1509    CG1  CG2                                            
REMARK 470     ILE A1510    CG1  CG2  CD1                                       
REMARK 470     PRO A1511    CG   CD                                             
REMARK 470     PRO A1512    CG   CD                                             
REMARK 470     ILE A1513    CG1  CG2  CD1                                       
REMARK 470     ASP A1515    CG   OD1  OD2                                       
REMARK 470     GLN B  75    CG   CD   OE1  NE2                                  
REMARK 470     PRO B  77    CG   CD                                             
REMARK 470     HIS B  78    CG   ND1  CD2  CE1  NE2                             
REMARK 470     MET B  79    CG   SD   CE                                        
REMARK 470     LEU B  81    CG   CD1  CD2                                       
REMARK 470     ARG B  82    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B  83    CG   CD   CE   NZ                                   
REMARK 470     GLU B  84    CG   CD   OE1  OE2                                  
REMARK 470     ARG B  87    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B  88    CG   CD   OE1  NE2                                  
REMARK 470     LEU B  90    CD1  CD2                                            
REMARK 470     GLU B  94    CG   CD   OE1  OE2                                  
REMARK 470     LYS B  95    CG   CD   CE   NZ                                   
REMARK 470     ASN B 112    OD1  ND2                                            
REMARK 470     PRO B 113    CG   CD                                             
REMARK 470     SER B 114    OG                                                  
REMARK 470     PRO B 115    CD                                                  
REMARK 470     GLU B 118    CD   OE1  OE2                                       
REMARK 470     GLU B 122    CD   OE1  OE2                                       
REMARK 470     VAL B 124    CG1                                                 
REMARK 470     THR B 127    CG2                                                 
REMARK 470     PRO B 130    CG   CD                                             
REMARK 470     ILE B 136    CG2  CD1                                            
REMARK 470     TYR B 140    CD1  CD2  CE1  CE2  CZ   OH                         
REMARK 470     VAL B 156    CG2                                                 
REMARK 470     ASP B 166    OD1  OD2                                            
REMARK 470     LEU B 168    CD1  CD2                                            
REMARK 470     LEU B 171    CD1  CD2                                            
REMARK 470     GLN B 172    CD   OE1  NE2                                       
REMARK 470     ILE C 277    CG2  CD1                                            
REMARK 470     ILE C 278    CG2  CD1                                            
REMARK 470     LEU C 304    CD1  CD2                                            
REMARK 470     ASP C 306    OD1  OD2                                            
REMARK 470     ARG C 341    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE C 386    CG2  CD1                                            
REMARK 470     ILE C 389    CG2  CD1                                            
REMARK 470     THR C 392    CG2                                                 
REMARK 470     SER C 409    OG                                                  
REMARK 470     ILE C 416    CG2  CD1                                            
REMARK 470     SER C 419    OG                                                  
REMARK 470     GLU C 420    CD   OE1  OE2                                       
REMARK 470     MET C 429    SD   CE                                             
REMARK 470     ILE C 432    CG2  CD1                                            
REMARK 470     GLU C 448    CD   OE1  OE2                                       
REMARK 470     LYS C 455    CE   NZ                                             
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   ND2  ASN A   269     CE2  TYR A   621              1.84            
REMARK 500   CG2  ILE A  1380     CE2  PHE A  1384              2.14            
REMARK 500   OH   TYR A    71     NH2  ARG A   165              2.17            
REMARK 500   CG   ARG A   165     NH2  ARG A   168              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    ASP A1339   C     PRO A1340   N      -0.117                       
REMARK 500    PRO F 527   CD    PRO F 527   N       0.088                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    SER A 618   CB  -  CA  -  C   ANGL. DEV. =  15.2 DEGREES          
REMARK 500    ALA A 673   CB  -  CA  -  C   ANGL. DEV. =  -9.9 DEGREES          
REMARK 500    CYS A1100   CA  -  CB  -  SG  ANGL. DEV. =   8.3 DEGREES          
REMARK 500    PRO A1310   CB  -  CA  -  C   ANGL. DEV. =  13.1 DEGREES          
REMARK 500    LEU A1316   CB  -  CA  -  C   ANGL. DEV. =  12.6 DEGREES          
REMARK 500    PRO A1396   C   -  N   -  CD  ANGL. DEV. =  12.7 DEGREES          
REMARK 500    ALA E  33   CB  -  CA  -  C   ANGL. DEV. = -14.8 DEGREES          
REMARK 500    TYR E 176   CB  -  CA  -  C   ANGL. DEV. =  17.2 DEGREES          
REMARK 500    TYR E 176   N   -  CA  -  C   ANGL. DEV. = -23.5 DEGREES          
REMARK 500    VAL F 161   CB  -  CA  -  C   ANGL. DEV. = -15.4 DEGREES          
REMARK 500    PRO F 221   C   -  N   -  CD  ANGL. DEV. = -12.7 DEGREES          
REMARK 500    LEU F 259   CB  -  CA  -  C   ANGL. DEV. = -15.1 DEGREES          
REMARK 500    ALA F 300   CB  -  CA  -  C   ANGL. DEV. =  13.3 DEGREES          
REMARK 500    CYS F 305   CA  -  CB  -  SG  ANGL. DEV. =   9.8 DEGREES          
REMARK 500    ARG F 385   CB  -  CA  -  C   ANGL. DEV. = -16.1 DEGREES          
REMARK 500    PHE F 387   CB  -  CA  -  C   ANGL. DEV. =  13.0 DEGREES          
REMARK 500    PHE F 387   N   -  CA  -  C   ANGL. DEV. = -17.8 DEGREES          
REMARK 500    PHE F 389   CB  -  CA  -  C   ANGL. DEV. = -13.5 DEGREES          
REMARK 500    SER F 390   CB  -  CA  -  C   ANGL. DEV. =  17.1 DEGREES          
REMARK 500    SER F 390   N   -  CA  -  C   ANGL. DEV. = -21.4 DEGREES          
REMARK 500    TYR F 413   CB  -  CA  -  C   ANGL. DEV. = -18.6 DEGREES          
REMARK 500    GLN F 447   CB  -  CA  -  C   ANGL. DEV. =  14.4 DEGREES          
REMARK 500    GLN F 447   N   -  CA  -  C   ANGL. DEV. = -21.5 DEGREES          
REMARK 500    GLN F 551   C   -  N   -  CA  ANGL. DEV. =  16.9 DEGREES          
REMARK 500    TYR F 609   CA  -  CB  -  CG  ANGL. DEV. =  12.9 DEGREES          
REMARK 500    TYR F 661   CB  -  CA  -  C   ANGL. DEV. =  15.7 DEGREES          
REMARK 500    TYR F 661   N   -  CA  -  C   ANGL. DEV. = -24.4 DEGREES          
REMARK 500    PHE F 663   CB  -  CA  -  C   ANGL. DEV. = -15.7 DEGREES          
REMARK 500    PRO F 788   C   -  N   -  CA  ANGL. DEV. =   9.3 DEGREES          
REMARK 500    SER F 798   CB  -  CA  -  C   ANGL. DEV. = -13.6 DEGREES          
REMARK 500    CYS F1074   O   -  C   -  N   ANGL. DEV. = -18.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    CYS A  33       70.26     58.62                                   
REMARK 500    THR A  35       -5.09     71.75                                   
REMARK 500    PRO A  52        7.50    -65.41                                   
REMARK 500    GLU A  76       64.25   -102.81                                   
REMARK 500    ASP A  77       73.61     56.29                                   
REMARK 500    ASN A  80      -84.03    -86.45                                   
REMARK 500    SER A  81      -37.62   -142.68                                   
REMARK 500    HIS A 113       32.90    -94.83                                   
REMARK 500    SER A 181       -8.87     69.33                                   
REMARK 500    PRO A 195       42.20    -83.35                                   
REMARK 500    TYR A 228     -167.79    -76.08                                   
REMARK 500    GLU A 238      -32.16     60.46                                   
REMARK 500    CYS A 254       49.91     71.52                                   
REMARK 500    ASN A 257       69.93     61.14                                   
REMARK 500    PRO A 268     -173.55    -68.64                                   
REMARK 500    ASN A 269      -57.42    -27.82                                   
REMARK 500    HIS A 270       20.72   -141.46                                   
REMARK 500    PHE A 275       35.55    -95.62                                   
REMARK 500    ASN A 277       83.84     63.35                                   
REMARK 500    PHE A 278      -58.33    -23.23                                   
REMARK 500    GLU A 292       89.69   -150.89                                   
REMARK 500    ILE A 305      -64.07    -93.31                                   
REMARK 500    GLU A 308       14.12     49.35                                   
REMARK 500    TRP A 309       22.06   -145.39                                   
REMARK 500    ARG A 422       -2.00     72.62                                   
REMARK 500    SER A 451     -146.98    -78.39                                   
REMARK 500    GLU A 452       70.72     69.65                                   
REMARK 500    GLN A 456       80.61     54.05                                   
REMARK 500    LEU A 458      -25.30   -147.01                                   
REMARK 500    LEU A 486      -38.33   -136.16                                   
REMARK 500    TYR A 541     -160.08    -78.52                                   
REMARK 500    TRP A 542       98.20     55.97                                   
REMARK 500    ASP A 586      -61.65    -97.47                                   
REMARK 500    PHE A 587      -35.40     73.41                                   
REMARK 500    ASP A 598       47.82    -92.91                                   
REMARK 500    ASN A 599     -179.75   -173.38                                   
REMARK 500    PRO A 821        3.96    -48.19                                   
REMARK 500    ARG A 823      -41.10   -135.87                                   
REMARK 500    ALA A 824      -11.00     67.75                                   
REMARK 500    LYS A 894      -36.77   -132.90                                   
REMARK 500    ILE A 908       39.72    -77.44                                   
REMARK 500    HIS A 916      -60.54   -102.15                                   
REMARK 500    LEU A 960       46.18    -79.41                                   
REMARK 500    SER A 961       20.21   -147.95                                   
REMARK 500    MET A 963      -11.95     71.41                                   
REMARK 500    ASP A 977      135.05    -33.22                                   
REMARK 500    ASN A 993       46.50    -82.11                                   
REMARK 500    ASP A 994      -11.21     62.41                                   
REMARK 500    ASN A1027     -162.69   -126.37                                   
REMARK 500    ASN A1036       32.47   -144.20                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     201 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ASN A   38     PRO A   39                 -130.47                    
REMARK 500 PRO A  268     ASN A  269                 -125.44                    
REMARK 500 ASP A  276     ASN A  277                  141.09                    
REMARK 500 TRP A  309     PRO A  310                  148.17                    
REMARK 500 ALA A  450     SER A  451                  144.61                    
REMARK 500 ASP A  820     PRO A  821                 -113.26                    
REMARK 500 LYS A  976     ASP A  977                 -142.53                    
REMARK 500 ASP A  977     GLY A  978                 -143.12                    
REMARK 500 ASN A  993     ASP A  994                  149.03                    
REMARK 500 HIS A 1141     GLN A 1142                 -142.57                    
REMARK 500 LYS A 1173     ALA A 1174                 -133.94                    
REMARK 500 ALA A 1293     LEU A 1294                 -147.43                    
REMARK 500 TYR A 1344     ALA A 1345                 -144.48                    
REMARK 500 PRO A 1346     GLY A 1347                  146.91                    
REMARK 500 ASP A 1382     ASN A 1383                 -147.01                    
REMARK 500 HIS A 1441     ARG A 1442                  144.86                    
REMARK 500 VAL C  280     GLY C  281                  145.69                    
REMARK 500 GLY C  281     PRO C  282                  146.19                    
REMARK 500 MET E  207     PRO E  208                 -118.84                    
REMARK 500 PRO E  208     GLN E  209                  136.91                    
REMARK 500 GLU F  176     GLY F  177                 -131.07                    
REMARK 500 TYR F  220     PRO F  221                  106.42                    
REMARK 500 GLU F  476     ASN F  477                 -106.47                    
REMARK 500 ASN F  477     LYS F  478                  149.92                    
REMARK 500 GLN F  484     LEU F  485                 -146.28                    
REMARK 500 PRO F  527     ASN F  528                  148.47                    
REMARK 500 ILE F  534     GLY F  535                  138.74                    
REMARK 500 ARG F  600     TYR F  601                 -145.42                    
REMARK 500 LYS F  730     GLY F  731                 -129.38                    
REMARK 500 LYS F  785     SER F  786                  142.76                    
REMARK 500 SER F  786     GLY F  787                 -142.52                    
REMARK 500 ILE F  805     GLN F  806                 -142.31                    
REMARK 500 ILE F  892     SER F  893                 -129.36                    
REMARK 500 SER F  893     VAL F  894                 -107.75                    
REMARK 500 VAL F  894     TYR F  895                   85.90                    
REMARK 500 GLU F 1022     SER F 1023                  126.15                    
REMARK 500 CYS F 1074     ETA F 1075                  132.84                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    CYS F1074         19.32                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 1902                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 1903                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA F 1201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG A 1901        
REMARK 800  bound to ASN A 257                                                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG F 1214        
REMARK 800  bound to ASN F 94                                                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues BMA F    
REMARK 800  1208 through NAG F 1210 bound to ASN F 186                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG F 1204        
REMARK 800  bound to ASN F 326                                                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG F    
REMARK 800  1202 through NAG F 1203 bound to ASN F 350                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG F    
REMARK 800  1211 through BMA F 1213 bound to ASN F 470                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG F 1215        
REMARK 800  bound to ASN F 606                                                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG F    
REMARK 800  1205 through NAG F 1206 bound to ASN F 615                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG F    
REMARK 800  1218 through NAG F 1219 bound to ASN F 678                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG F 1220        
REMARK 800  bound to ASN F 784                                                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG F    
REMARK 800  1223 through NAG F 1225 bound to ASN F 827                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG F 1207        
REMARK 800  bound to ASN F 891                                                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG F    
REMARK 800  1216 through NAG F 1217 bound to ASN F 898                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG F 1222        
REMARK 800  bound to ASN F 988                                                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG F 1221        
REMARK 800  bound to ASN F 1001                                                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-9515   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-9514   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 5GJV   RELATED DB: PDB                                   
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 RESIDUE F1075 IS DUE TO GPI MODIFICATION.                            
DBREF  5GJW A    1  1873  UNP    P07293   CAC1S_RABIT      1   1873             
DBREF  5GJW B   80   174  UNP    P19517   CACB1_RABIT     80    174             
DBREF  5GJW C  265   463  UNP    P19517   CACB1_RABIT    265    463             
DBREF  5GJW E    1   222  UNP    P19518   CCG1_RABIT       1    222             
DBREF  5GJW F    1  1106  UNP    P13806   CA2D1_RABIT      1   1106             
SEQADV 5GJW SER B   69  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW LEU B   70  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW GLU B   71  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW VAL B   72  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW LEU B   73  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW PHE B   74  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW GLN B   75  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW GLY B   76  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW PRO B   77  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW HIS B   78  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW MET B   79  UNP  P19517              EXPRESSION TAG                 
SEQADV 5GJW ETA F 1075  UNP  P13806    GLY  1075 SEE SEQUENCE DETAILS           
SEQRES   1 A 1873  MET GLU PRO SER SER PRO GLN ASP GLU GLY LEU ARG LYS          
SEQRES   2 A 1873  LYS GLN PRO LYS LYS PRO LEU PRO GLU VAL LEU PRO ARG          
SEQRES   3 A 1873  PRO PRO ARG ALA LEU PHE CYS LEU THR LEU GLN ASN PRO          
SEQRES   4 A 1873  LEU ARG LYS ALA CYS ILE SER ILE VAL GLU TRP LYS PRO          
SEQRES   5 A 1873  PHE GLU THR ILE ILE LEU LEU THR ILE PHE ALA ASN CYS          
SEQRES   6 A 1873  VAL ALA LEU ALA VAL TYR LEU PRO MET PRO GLU ASP ASP          
SEQRES   7 A 1873  ASN ASN SER LEU ASN LEU GLY LEU GLU LYS LEU GLU TYR          
SEQRES   8 A 1873  PHE PHE LEU THR VAL PHE SER ILE GLU ALA ALA MET LYS          
SEQRES   9 A 1873  ILE ILE ALA TYR GLY PHE LEU PHE HIS GLN ASP ALA TYR          
SEQRES  10 A 1873  LEU ARG SER GLY TRP ASN VAL LEU ASP PHE ILE ILE VAL          
SEQRES  11 A 1873  PHE LEU GLY VAL PHE THR ALA ILE LEU GLU GLN VAL ASN          
SEQRES  12 A 1873  VAL ILE GLN SER ASN THR ALA PRO MET SER SER LYS GLY          
SEQRES  13 A 1873  ALA GLY LEU ASP VAL LYS ALA LEU ARG ALA PHE ARG VAL          
SEQRES  14 A 1873  LEU ARG PRO LEU ARG LEU VAL SER GLY VAL PRO SER LEU          
SEQRES  15 A 1873  GLN VAL VAL LEU ASN SER ILE PHE LYS ALA MET LEU PRO          
SEQRES  16 A 1873  LEU PHE HIS ILE ALA LEU LEU VAL LEU PHE MET VAL ILE          
SEQRES  17 A 1873  ILE TYR ALA ILE ILE GLY LEU GLU LEU PHE LYS GLY LYS          
SEQRES  18 A 1873  MET HIS LYS THR CYS TYR TYR ILE GLY THR ASP ILE VAL          
SEQRES  19 A 1873  ALA THR VAL GLU ASN GLU LYS PRO SER PRO CYS ALA ARG          
SEQRES  20 A 1873  THR GLY SER GLY ARG PRO CYS THR ILE ASN GLY SER GLU          
SEQRES  21 A 1873  CYS ARG GLY GLY TRP PRO GLY PRO ASN HIS GLY ILE THR          
SEQRES  22 A 1873  HIS PHE ASP ASN PHE GLY PHE SER MET LEU THR VAL TYR          
SEQRES  23 A 1873  GLN CYS ILE THR MET GLU GLY TRP THR ASP VAL LEU TYR          
SEQRES  24 A 1873  TRP VAL ASN ASP ALA ILE GLY ASN GLU TRP PRO TRP ILE          
SEQRES  25 A 1873  TYR PHE VAL THR LEU ILE LEU LEU GLY SER PHE PHE ILE          
SEQRES  26 A 1873  LEU ASN LEU VAL LEU GLY VAL LEU SER GLY GLU PHE THR          
SEQRES  27 A 1873  LYS GLU ARG GLU LYS ALA LYS SER ARG GLY THR PHE GLN          
SEQRES  28 A 1873  LYS LEU ARG GLU LYS GLN GLN LEU GLU GLU ASP LEU ARG          
SEQRES  29 A 1873  GLY TYR MET SER TRP ILE THR GLN GLY GLU VAL MET ASP          
SEQRES  30 A 1873  VAL GLU ASP LEU ARG GLU GLY LYS LEU SER LEU GLU GLU          
SEQRES  31 A 1873  GLY GLY SER ASP THR GLU SER LEU TYR GLU ILE GLU GLY          
SEQRES  32 A 1873  LEU ASN LYS ILE ILE GLN PHE ILE ARG HIS TRP ARG GLN          
SEQRES  33 A 1873  TRP ASN ARG VAL PHE ARG TRP LYS CYS HIS ASP LEU VAL          
SEQRES  34 A 1873  LYS SER ARG VAL PHE TYR TRP LEU VAL ILE LEU ILE VAL          
SEQRES  35 A 1873  ALA LEU ASN THR LEU SER ILE ALA SER GLU HIS HIS ASN          
SEQRES  36 A 1873  GLN PRO LEU TRP LEU THR HIS LEU GLN ASP ILE ALA ASN          
SEQRES  37 A 1873  ARG VAL LEU LEU SER LEU PHE THR ILE GLU MET LEU LEU          
SEQRES  38 A 1873  LYS MET TYR GLY LEU GLY LEU ARG GLN TYR PHE MET SER          
SEQRES  39 A 1873  ILE PHE ASN ARG PHE ASP CYS PHE VAL VAL CYS SER GLY          
SEQRES  40 A 1873  ILE LEU GLU LEU LEU LEU VAL GLU SER GLY ALA MET THR          
SEQRES  41 A 1873  PRO LEU GLY ILE SER VAL LEU ARG CYS ILE ARG LEU LEU          
SEQRES  42 A 1873  ARG LEU PHE LYS ILE THR LYS TYR TRP THR SER LEU SER          
SEQRES  43 A 1873  ASN LEU VAL ALA SER LEU LEU ASN SER ILE ARG SER ILE          
SEQRES  44 A 1873  ALA SER LEU LEU LEU LEU LEU PHE LEU PHE ILE ILE ILE          
SEQRES  45 A 1873  PHE ALA LEU LEU GLY MET GLN LEU PHE GLY GLY ARG TYR          
SEQRES  46 A 1873  ASP PHE GLU ASP THR GLU VAL ARG ARG SER ASN PHE ASP          
SEQRES  47 A 1873  ASN PHE PRO GLN ALA LEU ILE SER VAL PHE GLN VAL LEU          
SEQRES  48 A 1873  THR GLY GLU ASP TRP ASN SER VAL MET TYR ASN GLY ILE          
SEQRES  49 A 1873  MET ALA TYR GLY GLY PRO SER TYR PRO GLY VAL LEU VAL          
SEQRES  50 A 1873  CYS ILE TYR PHE ILE ILE LEU PHE VAL CYS GLY ASN TYR          
SEQRES  51 A 1873  ILE LEU LEU ASN VAL PHE LEU ALA ILE ALA VAL ASP ASN          
SEQRES  52 A 1873  LEU ALA GLU ALA GLU SER LEU THR SER ALA GLN LYS ALA          
SEQRES  53 A 1873  LYS ALA GLU GLU ARG LYS ARG ARG LYS MET SER ARG GLY          
SEQRES  54 A 1873  LEU PRO ASP LYS THR GLU GLU GLU LYS SER VAL MET ALA          
SEQRES  55 A 1873  LYS LYS LEU GLU GLN LYS PRO LYS GLY GLU GLY ILE PRO          
SEQRES  56 A 1873  THR THR ALA LYS LEU LYS VAL ASP GLU PHE GLU SER ASN          
SEQRES  57 A 1873  VAL ASN GLU VAL LYS ASP PRO TYR PRO SER ALA ASP PHE          
SEQRES  58 A 1873  PRO GLY ASP ASP GLU GLU ASP GLU PRO GLU ILE PRO VAL          
SEQRES  59 A 1873  SER PRO ARG PRO ARG PRO LEU ALA GLU LEU GLN LEU LYS          
SEQRES  60 A 1873  GLU LYS ALA VAL PRO ILE PRO GLU ALA SER SER PHE PHE          
SEQRES  61 A 1873  ILE PHE SER PRO THR ASN LYS VAL ARG VAL LEU CYS HIS          
SEQRES  62 A 1873  ARG ILE VAL ASN ALA THR TRP PHE THR ASN PHE ILE LEU          
SEQRES  63 A 1873  LEU PHE ILE LEU LEU SER SER ALA ALA LEU ALA ALA GLU          
SEQRES  64 A 1873  ASP PRO ILE ARG ALA GLU SER VAL ARG ASN GLN ILE LEU          
SEQRES  65 A 1873  GLY TYR PHE ASP ILE ALA PHE THR SER VAL PHE THR VAL          
SEQRES  66 A 1873  GLU ILE VAL LEU LYS MET THR THR TYR GLY ALA PHE LEU          
SEQRES  67 A 1873  HIS LYS GLY SER PHE CYS ARG ASN TYR PHE ASN ILE LEU          
SEQRES  68 A 1873  ASP LEU LEU VAL VAL ALA VAL SER LEU ILE SER MET GLY          
SEQRES  69 A 1873  LEU GLU SER SER THR ILE SER VAL VAL LYS ILE LEU ARG          
SEQRES  70 A 1873  VAL LEU ARG VAL LEU ARG PRO LEU ARG ALA ILE ASN ARG          
SEQRES  71 A 1873  ALA LYS GLY LEU LYS HIS VAL VAL GLN CYS VAL PHE VAL          
SEQRES  72 A 1873  ALA ILE ARG THR ILE GLY ASN ILE VAL LEU VAL THR THR          
SEQRES  73 A 1873  LEU LEU GLN PHE MET PHE ALA CYS ILE GLY VAL GLN LEU          
SEQRES  74 A 1873  PHE LYS GLY LYS PHE PHE SER CYS ASN ASP LEU SER LYS          
SEQRES  75 A 1873  MET THR GLU GLU GLU CYS ARG GLY TYR TYR TYR VAL TYR          
SEQRES  76 A 1873  LYS ASP GLY ASP PRO THR GLN MET GLU LEU ARG PRO ARG          
SEQRES  77 A 1873  GLN TRP ILE HIS ASN ASP PHE HIS PHE ASP ASN VAL LEU          
SEQRES  78 A 1873  SER ALA MET MET SER LEU PHE THR VAL SER THR PHE GLU          
SEQRES  79 A 1873  GLY TRP PRO GLN LEU LEU TYR ARG ALA ILE ASP SER ASN          
SEQRES  80 A 1873  GLU GLU ASP MET GLY PRO VAL TYR ASN ASN ARG VAL GLU          
SEQRES  81 A 1873  MET ALA ILE PHE PHE ILE ILE TYR ILE ILE LEU ILE ALA          
SEQRES  82 A 1873  PHE PHE MET MET ASN ILE PHE VAL GLY PHE VAL ILE VAL          
SEQRES  83 A 1873  THR PHE GLN GLU GLN GLY GLU THR GLU TYR LYS ASN CYS          
SEQRES  84 A 1873  GLU LEU ASP LYS ASN GLN ARG GLN CYS VAL GLN TYR ALA          
SEQRES  85 A 1873  LEU LYS ALA ARG PRO LEU ARG CYS TYR ILE PRO LYS ASN          
SEQRES  86 A 1873  PRO TYR GLN TYR GLN VAL TRP TYR VAL VAL THR SER SER          
SEQRES  87 A 1873  TYR PHE GLU TYR LEU MET PHE ALA LEU ILE MET LEU ASN          
SEQRES  88 A 1873  THR ILE CYS LEU GLY MET GLN HIS TYR HIS GLN SER GLU          
SEQRES  89 A 1873  GLU MET ASN HIS ILE SER ASP ILE LEU ASN VAL ALA PHE          
SEQRES  90 A 1873  THR ILE ILE PHE THR LEU GLU MET ILE LEU LYS LEU LEU          
SEQRES  91 A 1873  ALA PHE LYS ALA ARG GLY TYR PHE GLY ASP PRO TRP ASN          
SEQRES  92 A 1873  VAL PHE ASP PHE LEU ILE VAL ILE GLY SER ILE ILE ASP          
SEQRES  93 A 1873  VAL ILE LEU SER GLU ILE ASP THR PHE LEU ALA SER SER          
SEQRES  94 A 1873  GLY GLY LEU TYR CYS LEU GLY GLY GLY CYS GLY ASN VAL          
SEQRES  95 A 1873  ASP PRO ASP GLU SER ALA ARG ILE SER SER ALA PHE PHE          
SEQRES  96 A 1873  ARG LEU PHE ARG VAL MET ARG LEU ILE LYS LEU LEU SER          
SEQRES  97 A 1873  ARG ALA GLU GLY VAL ARG THR LEU LEU TRP THR PHE ILE          
SEQRES  98 A 1873  LYS SER PHE GLN ALA LEU PRO TYR VAL ALA LEU LEU ILE          
SEQRES  99 A 1873  VAL MET LEU PHE PHE ILE TYR ALA VAL ILE GLY MET GLN          
SEQRES 100 A 1873  MET PHE GLY LYS ILE ALA LEU VAL ASP GLY THR GLN ILE          
SEQRES 101 A 1873  ASN ARG ASN ASN ASN PHE GLN THR PHE PRO GLN ALA VAL          
SEQRES 102 A 1873  LEU LEU LEU PHE ARG CYS ALA THR GLY GLU ALA TRP GLN          
SEQRES 103 A 1873  GLU ILE LEU LEU ALA CYS SER TYR GLY LYS LEU CYS ASP          
SEQRES 104 A 1873  PRO GLU SER ASP TYR ALA PRO GLY GLU GLU TYR THR CYS          
SEQRES 105 A 1873  GLY THR ASN PHE ALA TYR TYR TYR PHE ILE SER PHE TYR          
SEQRES 106 A 1873  MET LEU CYS ALA PHE LEU ILE ILE ASN LEU PHE VAL ALA          
SEQRES 107 A 1873  VAL ILE MET ASP ASN PHE ASP TYR LEU THR ARG ASP TRP          
SEQRES 108 A 1873  SER ILE LEU GLY PRO HIS HIS LEU ASP GLU PHE LYS ALA          
SEQRES 109 A 1873  ILE TRP ALA GLU TYR ASP PRO GLU ALA LYS GLY ARG ILE          
SEQRES 110 A 1873  LYS HIS LEU ASP VAL VAL THR LEU LEU ARG ARG ILE GLN          
SEQRES 111 A 1873  PRO PRO LEU GLY PHE GLY LYS PHE CYS PRO HIS ARG VAL          
SEQRES 112 A 1873  ALA CYS LYS ARG LEU VAL GLY MET ASN MET PRO LEU ASN          
SEQRES 113 A 1873  SER ASP GLY THR VAL THR PHE ASN ALA THR LEU PHE ALA          
SEQRES 114 A 1873  LEU VAL ARG THR ALA LEU LYS ILE LYS THR GLU GLY ASN          
SEQRES 115 A 1873  PHE GLU GLN ALA ASN GLU GLU LEU ARG ALA ILE ILE LYS          
SEQRES 116 A 1873  LYS ILE TRP LYS ARG THR SER MET LYS LEU LEU ASP GLN          
SEQRES 117 A 1873  VAL ILE PRO PRO ILE GLY ASP ASP GLU VAL THR VAL GLY          
SEQRES 118 A 1873  LYS PHE TYR ALA THR PHE LEU ILE GLN GLU HIS PHE ARG          
SEQRES 119 A 1873  LYS PHE MET LYS ARG GLN GLU GLU TYR TYR GLY TYR ARG          
SEQRES 120 A 1873  PRO LYS LYS ASP THR VAL GLN ILE GLN ALA GLY LEU ARG          
SEQRES 121 A 1873  THR ILE GLU GLU GLU ALA ALA PRO GLU ILE ARG ARG THR          
SEQRES 122 A 1873  ILE SER GLY ASP LEU THR ALA GLU GLU GLU LEU GLU ARG          
SEQRES 123 A 1873  ALA MET VAL GLU ALA ALA MET GLU GLU ARG ILE PHE ARG          
SEQRES 124 A 1873  ARG THR GLY GLY LEU PHE GLY GLN VAL ASP THR PHE LEU          
SEQRES 125 A 1873  GLU ARG THR ASN SER LEU PRO PRO VAL MET ALA ASN GLN          
SEQRES 126 A 1873  ARG PRO LEU GLN PHE ALA GLU ILE GLU MET GLU GLU LEU          
SEQRES 127 A 1873  GLU SER PRO VAL PHE LEU GLU ASP PHE PRO GLN ASP ALA          
SEQRES 128 A 1873  ARG THR ASN PRO LEU ALA ARG ALA ASN THR ASN ASN ALA          
SEQRES 129 A 1873  ASN ALA ASN VAL ALA TYR GLY ASN SER ASN HIS SER ASN          
SEQRES 130 A 1873  ASN GLN MET PHE SER SER VAL HIS CYS GLU ARG GLU PHE          
SEQRES 131 A 1873  PRO GLY GLU ALA GLU THR PRO ALA ALA GLY ARG GLY ALA          
SEQRES 132 A 1873  LEU SER HIS SER HIS ARG ALA LEU GLY PRO HIS SER LYS          
SEQRES 133 A 1873  PRO CYS ALA GLY LYS LEU ASN GLY GLN LEU VAL GLN PRO          
SEQRES 134 A 1873  GLY MET PRO ILE ASN GLN ALA PRO PRO ALA PRO CYS GLN          
SEQRES 135 A 1873  GLN PRO SER THR ASP PRO PRO GLU ARG GLY GLN ARG ARG          
SEQRES 136 A 1873  THR SER LEU THR GLY SER LEU GLN ASP GLU ALA PRO GLN          
SEQRES 137 A 1873  ARG ARG SER SER GLU GLY SER THR PRO ARG ARG PRO ALA          
SEQRES 138 A 1873  PRO ALA THR ALA LEU LEU ILE GLN GLU ALA LEU VAL ARG          
SEQRES 139 A 1873  GLY GLY LEU ASP THR LEU ALA ALA ASP ALA GLY PHE VAL          
SEQRES 140 A 1873  THR ALA THR SER GLN ALA LEU ALA ASP ALA CYS GLN MET          
SEQRES 141 A 1873  GLU PRO GLU GLU VAL GLU VAL ALA ALA THR GLU LEU LEU          
SEQRES 142 A 1873  LYS ALA ARG GLU SER VAL GLN GLY MET ALA SER VAL PRO          
SEQRES 143 A 1873  GLY SER LEU SER ARG ARG SER SER LEU GLY SER LEU ASP          
SEQRES 144 A 1873  GLN VAL GLN GLY SER GLN GLU THR LEU ILE PRO PRO ARG          
SEQRES 145 A 1873  PRO                                                          
SEQRES   1 B  106  SER LEU GLU VAL LEU PHE GLN GLY PRO HIS MET ALA LEU          
SEQRES   2 B  106  ARG LYS GLU ALA GLU ARG GLN ALA LEU ALA GLN LEU GLU          
SEQRES   3 B  106  LYS ALA LYS THR LYS PRO VAL ALA PHE ALA VAL ARG THR          
SEQRES   4 B  106  ASN VAL GLY TYR ASN PRO SER PRO GLY ASP GLU VAL PRO          
SEQRES   5 B  106  VAL GLU GLY VAL ALA ILE THR PHE GLU PRO LYS ASP PHE          
SEQRES   6 B  106  LEU HIS ILE LYS GLU LYS TYR ASN ASN ASP TRP TRP ILE          
SEQRES   7 B  106  GLY ARG LEU VAL LYS GLU GLY CYS GLU VAL GLY PHE ILE          
SEQRES   8 B  106  PRO SER PRO VAL LYS LEU ASP SER LEU ARG LEU LEU GLN          
SEQRES   9 B  106  GLU GLN                                                      
SEQRES   1 C  199  VAL PRO PRO TYR ASP VAL VAL PRO SER MET ARG PRO ILE          
SEQRES   2 C  199  ILE LEU VAL GLY PRO SER LEU LYS GLY TYR GLU VAL THR          
SEQRES   3 C  199  ASP MET MET GLN LYS ALA LEU PHE ASP PHE LEU LYS HIS          
SEQRES   4 C  199  LEU PHE ASP GLY ARG ILE SER ILE THR ARG VAL THR ALA          
SEQRES   5 C  199  ASP ILE SER LEU ALA LYS ARG SER VAL LEU ASN ASN PRO          
SEQRES   6 C  199  SER LYS HIS ILE ILE ILE GLU ARG SER ASN THR ARG SER          
SEQRES   7 C  199  SER LEU ALA GLU VAL GLN SER GLU ILE GLU ARG ILE PHE          
SEQRES   8 C  199  GLU LEU ALA ARG THR LEU GLN LEU VAL ALA LEU ASP ALA          
SEQRES   9 C  199  ASP THR ILE ASN HIS PRO ALA GLN LEU SER LYS THR SER          
SEQRES  10 C  199  LEU ALA PRO ILE ILE VAL TYR ILE LYS ILE THR SER PRO          
SEQRES  11 C  199  LYS VAL LEU GLN ARG LEU ILE LYS SER ARG GLY LYS SER          
SEQRES  12 C  199  GLN SER LYS HIS LEU ASN VAL GLN ILE ALA ALA SER GLU          
SEQRES  13 C  199  LYS LEU ALA GLN CYS PRO PRO GLU MET PHE ASP ILE ILE          
SEQRES  14 C  199  LEU ASP GLU ASN GLN LEU GLU ASP ALA CYS GLU HIS LEU          
SEQRES  15 C  199  ALA GLU TYR LEU GLU ALA TYR TRP LYS ALA THR HIS PRO          
SEQRES  16 C  199  PRO SER SER THR                                              
SEQRES   1 E  222  MET SER PRO THR GLU ALA PRO LYS VAL ARG VAL THR LEU          
SEQRES   2 E  222  PHE CYS ILE LEU VAL GLY ILE VAL LEU ALA MET THR ALA          
SEQRES   3 E  222  VAL VAL SER ASP HIS TRP ALA VAL LEU SER PRO HIS MET          
SEQRES   4 E  222  GLU ASN HIS ASN THR THR CYS GLU ALA ALA HIS PHE GLY          
SEQRES   5 E  222  LEU TRP ARG ILE CYS THR LYS ARG ILE ALA LEU GLY GLU          
SEQRES   6 E  222  ASP ARG SER CYS GLY PRO ILE THR LEU PRO GLY GLU LYS          
SEQRES   7 E  222  ASN CYS SER TYR PHE ARG HIS PHE ASN PRO GLY GLU SER          
SEQRES   8 E  222  SER GLU ILE PHE GLU PHE THR THR GLN LYS GLU TYR SER          
SEQRES   9 E  222  ILE SER ALA ALA ALA ILE SER VAL PHE SER LEU GLY PHE          
SEQRES  10 E  222  LEU ILE MET GLY THR ILE CYS ALA LEU MET ALA PHE ARG          
SEQRES  11 E  222  LYS LYS ARG ASP TYR LEU LEU ARG PRO ALA SER MET PHE          
SEQRES  12 E  222  TYR VAL PHE ALA GLY LEU CYS LEU PHE VAL SER LEU GLU          
SEQRES  13 E  222  VAL MET ARG GLN SER VAL LYS ARG MET ILE ASP SER GLU          
SEQRES  14 E  222  ASP THR VAL TRP ILE GLU TYR TYR TYR SER TRP SER PHE          
SEQRES  15 E  222  ALA CYS ALA CYS ALA ALA PHE VAL LEU LEU PHE LEU GLY          
SEQRES  16 E  222  GLY ILE SER LEU LEU LEU PHE SER LEU PRO ARG MET PRO          
SEQRES  17 E  222  GLN ASN PRO TRP GLU SER CYS MET ASP ALA GLU PRO GLU          
SEQRES  18 E  222  HIS                                                          
SEQRES   1 F 1106  MET ALA ALA GLY ARG PRO LEU ALA TRP THR LEU THR LEU          
SEQRES   2 F 1106  TRP GLN ALA TRP LEU ILE LEU ILE GLY PRO SER SER GLU          
SEQRES   3 F 1106  GLU PRO PHE PRO SER ALA VAL THR ILE LYS SER TRP VAL          
SEQRES   4 F 1106  ASP LYS MET GLN GLU ASP LEU VAL THR LEU ALA LYS THR          
SEQRES   5 F 1106  ALA SER GLY VAL HIS GLN LEU VAL ASP ILE TYR GLU LYS          
SEQRES   6 F 1106  TYR GLN ASP LEU TYR THR VAL GLU PRO ASN ASN ALA ARG          
SEQRES   7 F 1106  GLN LEU VAL GLU ILE ALA ALA ARG ASP ILE GLU LYS LEU          
SEQRES   8 F 1106  LEU SER ASN ARG SER LYS ALA LEU VAL ARG LEU ALA LEU          
SEQRES   9 F 1106  GLU ALA GLU LYS VAL GLN ALA ALA HIS GLN TRP ARG GLU          
SEQRES  10 F 1106  ASP PHE ALA SER ASN GLU VAL VAL TYR TYR ASN ALA LYS          
SEQRES  11 F 1106  ASP ASP LEU ASP PRO GLU LYS ASN ASP SER GLU PRO GLY          
SEQRES  12 F 1106  SER GLN ARG ILE LYS PRO VAL PHE ILE ASP ASP ALA ASN          
SEQRES  13 F 1106  PHE ARG ARG GLN VAL SER TYR GLN HIS ALA ALA VAL HIS          
SEQRES  14 F 1106  ILE PRO THR ASP ILE TYR GLU GLY SER THR ILE VAL LEU          
SEQRES  15 F 1106  ASN GLU LEU ASN TRP THR SER ALA LEU ASP ASP VAL PHE          
SEQRES  16 F 1106  LYS LYS ASN ARG GLU GLU ASP PRO SER LEU LEU TRP GLN          
SEQRES  17 F 1106  VAL PHE GLY SER ALA THR GLY LEU ALA ARG TYR TYR PRO          
SEQRES  18 F 1106  ALA SER PRO TRP VAL ASP ASN SER ARG THR PRO ASN LYS          
SEQRES  19 F 1106  ILE ASP LEU TYR ASP VAL ARG ARG ARG PRO TRP TYR ILE          
SEQRES  20 F 1106  GLN GLY ALA ALA SER PRO LYS ASP MET LEU ILE LEU VAL          
SEQRES  21 F 1106  ASP VAL SER GLY SER VAL SER GLY LEU THR LEU LYS LEU          
SEQRES  22 F 1106  ILE ARG THR SER VAL SER GLU MET LEU GLU THR LEU SER          
SEQRES  23 F 1106  ASP ASP ASP PHE VAL ASN VAL ALA SER PHE ASN SER ASN          
SEQRES  24 F 1106  ALA GLN ASP VAL SER CYS PHE GLN HIS LEU VAL GLN ALA          
SEQRES  25 F 1106  ASN VAL ARG ASN LYS LYS VAL LEU LYS ASP ALA VAL ASN          
SEQRES  26 F 1106  ASN ILE THR ALA LYS GLY ILE THR ASP TYR LYS LYS GLY          
SEQRES  27 F 1106  PHE SER PHE ALA PHE GLU GLN LEU LEU ASN TYR ASN VAL          
SEQRES  28 F 1106  SER ARG ALA ASN CYS ASN LYS ILE ILE MET LEU PHE THR          
SEQRES  29 F 1106  ASP GLY GLY GLU GLU ARG ALA GLN GLU ILE PHE ALA LYS          
SEQRES  30 F 1106  TYR ASN LYS ASP LYS LYS VAL ARG VAL PHE THR PHE SER          
SEQRES  31 F 1106  VAL GLY GLN HIS ASN TYR ASP ARG GLY PRO ILE GLN TRP          
SEQRES  32 F 1106  MET ALA CYS GLU ASN LYS GLY TYR TYR TYR GLU ILE PRO          
SEQRES  33 F 1106  SER ILE GLY ALA ILE ARG ILE ASN THR GLN GLU TYR LEU          
SEQRES  34 F 1106  ASP VAL LEU GLY ARG PRO MET VAL LEU ALA GLY ASP LYS          
SEQRES  35 F 1106  ALA LYS GLN VAL GLN TRP THR ASN VAL TYR LEU ASP ALA          
SEQRES  36 F 1106  LEU GLU LEU GLY LEU VAL ILE THR GLY THR LEU PRO VAL          
SEQRES  37 F 1106  PHE ASN ILE THR GLY GLN PHE GLU ASN LYS THR ASN LEU          
SEQRES  38 F 1106  LYS ASN GLN LEU ILE LEU GLY VAL MET GLY VAL ASP VAL          
SEQRES  39 F 1106  SER LEU GLU ASP ILE LYS ARG LEU THR PRO ARG PHE THR          
SEQRES  40 F 1106  LEU CYS PRO ASN GLY TYR TYR PHE ALA ILE ASP PRO ASN          
SEQRES  41 F 1106  GLY TYR VAL LEU LEU HIS PRO ASN LEU GLN PRO LYS PRO          
SEQRES  42 F 1106  ILE GLY VAL GLY ILE PRO THR ILE ASN LEU ARG LYS ARG          
SEQRES  43 F 1106  ARG PRO ASN VAL GLN ASN PRO LYS SER GLN GLU PRO VAL          
SEQRES  44 F 1106  THR LEU ASP PHE LEU ASP ALA GLU LEU GLU ASN ASP ILE          
SEQRES  45 F 1106  LYS VAL GLU ILE ARG ASN LYS MET ILE ASP GLY GLU SER          
SEQRES  46 F 1106  GLY GLU LYS THR PHE ARG THR LEU VAL LYS SER GLN ASP          
SEQRES  47 F 1106  GLU ARG TYR ILE ASP LYS GLY ASN ARG THR TYR THR TRP          
SEQRES  48 F 1106  THR PRO VAL ASN GLY THR ASP TYR SER SER LEU ALA LEU          
SEQRES  49 F 1106  VAL LEU PRO THR TYR SER PHE TYR TYR ILE LYS ALA LYS          
SEQRES  50 F 1106  ILE GLU GLU THR ILE THR GLN ALA ARG TYR SER GLU THR          
SEQRES  51 F 1106  LEU LYS PRO ASP ASN PHE GLU GLU SER GLY TYR THR PHE          
SEQRES  52 F 1106  LEU ALA PRO ARG ASP TYR CYS SER ASP LEU LYS PRO SER          
SEQRES  53 F 1106  ASP ASN ASN THR GLU PHE LEU LEU ASN PHE ASN GLU PHE          
SEQRES  54 F 1106  ILE ASP ARG LYS THR PRO ASN ASN PRO SER CYS ASN THR          
SEQRES  55 F 1106  ASP LEU ILE ASN ARG VAL LEU LEU ASP ALA GLY PHE THR          
SEQRES  56 F 1106  ASN GLU LEU VAL GLN ASN TYR TRP SER LYS GLN LYS ASN          
SEQRES  57 F 1106  ILE LYS GLY VAL LYS ALA ARG PHE VAL VAL THR ASP GLY          
SEQRES  58 F 1106  GLY ILE THR ARG VAL TYR PRO LYS GLU ALA GLY GLU ASN          
SEQRES  59 F 1106  TRP GLN GLU ASN PRO GLU THR TYR GLU ASP SER PHE TYR          
SEQRES  60 F 1106  LYS ARG SER LEU ASP ASN ASP ASN TYR VAL PHE THR ALA          
SEQRES  61 F 1106  PRO TYR PHE ASN LYS SER GLY PRO GLY ALA TYR GLU SER          
SEQRES  62 F 1106  GLY ILE MET VAL SER LYS ALA VAL GLU ILE TYR ILE GLN          
SEQRES  63 F 1106  GLY LYS LEU LEU LYS PRO ALA VAL VAL GLY ILE LYS ILE          
SEQRES  64 F 1106  ASP VAL ASN SER TRP ILE GLU ASN PHE THR LYS THR SER          
SEQRES  65 F 1106  ILE ARG ASP PRO CYS ALA GLY PRO VAL CYS ASP CYS LYS          
SEQRES  66 F 1106  ARG ASN SER ASP VAL MET ASP CYS VAL ILE LEU ASP ASP          
SEQRES  67 F 1106  GLY GLY PHE LEU LEU MET ALA ASN HIS ASP ASP TYR THR          
SEQRES  68 F 1106  ASN GLN ILE GLY ARG PHE PHE GLY GLU ILE ASP PRO SER          
SEQRES  69 F 1106  LEU MET ARG HIS LEU VAL ASN ILE SER VAL TYR ALA PHE          
SEQRES  70 F 1106  ASN LYS SER TYR ASP TYR GLN SER VAL CYS GLU PRO GLY          
SEQRES  71 F 1106  ALA ALA PRO LYS GLN GLY ALA GLY HIS ARG SER ALA TYR          
SEQRES  72 F 1106  VAL PRO SER ILE ALA ASP ILE LEU GLN ILE GLY TRP TRP          
SEQRES  73 F 1106  ALA THR ALA ALA ALA TRP SER ILE LEU GLN GLN PHE LEU          
SEQRES  74 F 1106  LEU SER LEU THR PHE PRO ARG LEU LEU GLU ALA ALA ASP          
SEQRES  75 F 1106  MET GLU ASP ASP ASP PHE THR ALA SER MET SER LYS GLN          
SEQRES  76 F 1106  SER CYS ILE THR GLU GLN THR GLN TYR PHE PHE ASP ASN          
SEQRES  77 F 1106  ASP SER LYS SER PHE SER GLY VAL LEU ASP CYS GLY ASN          
SEQRES  78 F 1106  CYS SER ARG ILE PHE HIS VAL GLU LYS LEU MET ASN THR          
SEQRES  79 F 1106  ASN LEU ILE PHE ILE MET VAL GLU SER LYS GLY THR CYS          
SEQRES  80 F 1106  PRO CYS ASP THR ARG LEU LEU ILE GLN ALA GLU GLN THR          
SEQRES  81 F 1106  SER ASP GLY PRO ASP PRO CYS ASP MET VAL LYS GLN PRO          
SEQRES  82 F 1106  ARG TYR ARG LYS GLY PRO ASP VAL CYS PHE ASP ASN ASN          
SEQRES  83 F 1106  VAL LEU GLU ASP TYR THR ASP CYS ETA GLY VAL SER GLY          
SEQRES  84 F 1106  LEU ASN PRO SER LEU TRP SER ILE ILE GLY ILE GLN PHE          
SEQRES  85 F 1106  VAL LEU LEU TRP LEU VAL SER GLY SER ARG HIS CYS LEU          
SEQRES  86 F 1106  LEU                                                          
HET    ETA  F1075       4                                                       
HET    NAG  A1901      14                                                       
HET     CA  A1902       1                                                       
HET     CA  A1903       1                                                       
HET     CA  F1201       1                                                       
HET    NAG  F1202      14                                                       
HET    NAG  F1203      14                                                       
HET    NAG  F1204      14                                                       
HET    NAG  F1205      14                                                       
HET    NAG  F1206      14                                                       
HET    NAG  F1207      14                                                       
HET    BMA  F1208      11                                                       
HET    NAG  F1209      14                                                       
HET    NAG  F1210      14                                                       
HET    NAG  F1211      14                                                       
HET    NAG  F1212      14                                                       
HET    BMA  F1213      11                                                       
HET    NAG  F1214      14                                                       
HET    NAG  F1215      14                                                       
HET    NAG  F1216      14                                                       
HET    NAG  F1217      14                                                       
HET    NAG  F1218      14                                                       
HET    NAG  F1219      14                                                       
HET    NAG  F1220      14                                                       
HET    NAG  F1221      14                                                       
HET    NAG  F1222      14                                                       
HET    NAG  F1223      14                                                       
HET    NAG  F1224      14                                                       
HET    NAG  F1225      14                                                       
HETNAM     ETA ETHANOLAMINE                                                     
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE                                           
HETNAM      CA CALCIUM ION                                                      
HETNAM     BMA BETA-D-MANNOSE                                                   
FORMUL   5  ETA    C2 H7 N O                                                    
FORMUL   6  NAG    23(C8 H15 N O6)                                              
FORMUL   7   CA    3(CA 2+)                                                     
FORMUL  14  BMA    2(C6 H12 O6)                                                 
HELIX    1 AA1 LEU A   40  GLU A   49  1                                  10    
HELIX    2 AA2 PRO A   52  VAL A   70  1                                  19    
HELIX    3 AA3 SER A   81  TYR A  108  1                                  28    
HELIX    4 AA4 ASP A  115  LEU A  139  1                                  25    
HELIX    5 AA5 LYS A  162  PRO A  172  5                                  11    
HELIX    6 AA6 LEU A  173  VAL A  179  1                                   7    
HELIX    7 AA7 SER A  181  LEU A  194  1                                  14    
HELIX    8 AA8 PRO A  195  PHE A  197  5                                   3    
HELIX    9 AA9 ILE A  199  PHE A  218  1                                  20    
HELIX   10 AB1 ASN A  277  THR A  290  1                                  14    
HELIX   11 AB2 TRP A  294  ILE A  305  1                                  12    
HELIX   12 AB3 PRO A  310  LEU A  319  1                                  10    
HELIX   13 AB4 SER A  322  LYS A  343  1                                  22    
HELIX   14 AB5 LYS A  343  GLY A  348  1                                   6    
HELIX   15 AB6 GLY A  348  GLU A  374  1                                  27    
HELIX   16 AB7 TRP A  423  VAL A  429  1                                   7    
HELIX   17 AB8 SER A  431  TRP A  436  1                                   6    
HELIX   18 AB9 LEU A  437  LEU A  447  1                                  11    
HELIX   19 AC1 LEU A  458  GLY A  485  1                                  28    
HELIX   20 AC2 GLY A  487  PHE A  492  1                                   6    
HELIX   21 AC3 SER A  494  GLU A  515  1                                  22    
HELIX   22 AC4 THR A  520  ARG A  531  1                                  12    
HELIX   23 AC5 LEU A  532  ILE A  538  5                                   7    
HELIX   24 AC6 SER A  544  PHE A  581  1                                  38    
HELIX   25 AC7 PHE A  600  THR A  612  1                                  13    
HELIX   26 AC8 ASP A  615  GLY A  628  1                                  14    
HELIX   27 AC9 PRO A  633  LEU A  636  5                                   4    
HELIX   28 AD1 VAL A  637  LYS A  685  1                                  49    
HELIX   29 AD2 ARG A  789  ASN A  797  1                                   9    
HELIX   30 AD3 ALA A  798  ALA A  818  1                                  21    
HELIX   31 AD4 SER A  826  THR A  852  1                                  27    
HELIX   32 AD5 GLY A  855  HIS A  859  5                                   5    
HELIX   33 AD6 GLY A  861  MET A  883  1                                  23    
HELIX   34 AD7 LYS A  894  LEU A  899  1                                   6    
HELIX   35 AD8 ARG A  900  ARG A  910  5                                  11    
HELIX   36 AD9 HIS A  916  LYS A  951  1                                  36    
HELIX   37 AE1 ASN A  999  THR A 1012  1                                  14    
HELIX   38 AE2 GLY A 1015  ASP A 1025  1                                  11    
HELIX   39 AE3 ARG A 1038  GLU A 1040  5                                   3    
HELIX   40 AE4 MET A 1041  GLU A 1073  1                                  33    
HELIX   41 AE5 THR A 1074  ASN A 1078  5                                   5    
HELIX   42 AE6 LYS A 1083  ALA A 1095  1                                  13    
HELIX   43 AE7 ASN A 1105  THR A 1116  1                                  12    
HELIX   44 AE8 PHE A 1120  CYS A 1134  1                                  15    
HELIX   45 AE9 SER A 1143  PHE A 1172  1                                  30    
HELIX   46 AF1 GLY A 1176  GLY A 1179  5                                   4    
HELIX   47 AF2 ASP A 1180  PHE A 1205  1                                  26    
HELIX   48 AF3 ILE A 1230  PHE A 1235  1                                   6    
HELIX   49 AF4 ARG A 1236  MET A 1241  1                                   6    
HELIX   50 AF5 ARG A 1242  ARG A 1249  5                                   8    
HELIX   51 AF6 ALA A 1250  LEU A 1267  1                                  18    
HELIX   52 AF7 LEU A 1267  GLN A 1287  1                                  21    
HELIX   53 AF8 THR A 1308  THR A 1321  1                                  14    
HELIX   54 AF9 ALA A 1324  LEU A 1330  1                                   7    
HELIX   55 AG1 PHE A 1356  VAL A 1377  1                                  22    
HELIX   56 AG2 VAL A 1377  THR A 1388  1                                  12    
HELIX   57 AG3 PRO A 1396  ASP A 1410  1                                  15    
HELIX   58 AG4 HIS A 1419  ARG A 1428  1                                  10    
HELIX   59 AG5 ARG A 1442  GLY A 1450  1                                   9    
HELIX   60 AG6 PHE A 1463  LEU A 1475  1                                  13    
HELIX   61 AG7 GLY A 1481  TRP A 1498  1                                  18    
HELIX   62 AG8 MET A 1503  ASP A 1515  1                                  13    
HELIX   63 AG9 LYS B   83  LYS B   95  1                                  13    
HELIX   64 AH1 SER B  161  GLN B  174  1                                  14    
HELIX   65 AH2 VAL C  289  PHE C  305  1                                  17    
HELIX   66 AH3 ASP C  317  ALA C  321  5                                   5    
HELIX   67 AH4 SER C  343  ALA C  358  1                                  16    
HELIX   68 AH5 ARG C  359  LEU C  361  5                                   3    
HELIX   69 AH6 PRO C  374  SER C  378  5                                   5    
HELIX   70 AH7 SER C  393  ARG C  404  1                                  12    
HELIX   71 AH8 GLY C  405  LYS C  410  1                                   6    
HELIX   72 AH9 HIS C  411  CYS C  425  1                                  15    
HELIX   73 AI1 GLN C  438  HIS C  458  1                                  21    
HELIX   74 AI2 SER E    2  ALA E    6  1                                   5    
HELIX   75 AI3 PRO E    7  SER E   29  1                                  23    
HELIX   76 AI4 ILE E  105  ALA E  128  1                                  24    
HELIX   77 AI5 LEU E  136  ARG E  164  1                                  29    
HELIX   78 AI6 SER E  179  LEU E  204  1                                  26    
HELIX   79 AI7 SER F   31  SER F   54  1                                  24    
HELIX   80 AI8 GLY F   55  GLU F   64  1                                  10    
HELIX   81 AI9 ALA F   77  ALA F  112  1                                  36    
HELIX   82 AJ1 ILE F  180  THR F  188  1                                   9    
HELIX   83 AJ2 LEU F  191  ASP F  202  1                                  12    
HELIX   84 AJ3 ASP F  239  ARG F  242  5                                   4    
HELIX   85 AJ4 ARG F  243  GLY F  249  1                                   7    
HELIX   86 AJ5 SER F  263  SER F  267  5                                   5    
HELIX   87 AJ6 GLY F  268  LEU F  282  1                                  15    
HELIX   88 AJ7 GLU F  283  LEU F  285  5                                   3    
HELIX   89 AJ8 ASN F  313  ASN F  325  1                                  13    
HELIX   90 AJ9 TYR F  335  LEU F  346  1                                  12    
HELIX   91 AK1 ALA F  371  ASN F  379  1                                   9    
HELIX   92 AK2 ARG F  398  ASN F  408  1                                  11    
HELIX   93 AK3 ALA F  420  THR F  425  1                                   6    
HELIX   94 AK4 GLU F  427  LEU F  432  1                                   6    
HELIX   95 AK5 GLY F  433  LEU F  438  1                                   6    
HELIX   96 AK6 LEU F  496  ARG F  501  1                                   6    
HELIX   97 AK7 ASP F  562  GLU F  567  1                                   6    
HELIX   98 AK8 ASN F  570  ILE F  581  1                                  12    
HELIX   99 AK9 ILE F  642  LYS F  652  1                                  11    
HELIX  100 AL1 PRO F  653  PHE F  656  5                                   4    
HELIX  101 AL2 ASN F  678  THR F  694  1                                  17    
HELIX  102 AL3 ASP F  703  TYR F  722  1                                  20    
HELIX  103 AL4 ASP F  764  ASN F  773  1                                  10    
HELIX  104 AL5 ASP F  820  ILE F  833  1                                  14    
HELIX  105 AL6 PHE F  877  ILE F  881  5                                   5    
HELIX  106 AL7 ASP F  882  ILE F  892  1                                  11    
HELIX  107 AL8 ASP F 1045  VAL F 1050  1                                   6    
SHEET    1 AA1 2 PHE A 955  CYS A 957  0                                        
SHEET    2 AA1 2 TRP A 990  HIS A 992 -1  O  ILE A 991   N  SER A 956           
SHEET    1 AA2 2 TYR A 972  TYR A 975  0                                        
SHEET    2 AA2 2 MET A 983  ARG A 986 -1  O  GLU A 984   N  VAL A 974           
SHEET    1 AA3 2 ARG A1416  LYS A1418  0                                        
SHEET    2 AA3 2 THR A1460  THR A1462 -1  O  VAL A1461   N  ILE A1417           
SHEET    1 AA4 5 VAL B 156  PRO B 160  0                                        
SHEET    2 AA4 5 TRP B 144  LEU B 149 -1  N  TRP B 145   O  ILE B 159           
SHEET    3 AA4 5 PHE B 133  GLU B 138 -1  N  GLU B 138   O  ILE B 146           
SHEET    4 AA4 5 PHE B 103  THR B 107 -1  N  VAL B 105   O  LEU B 134           
SHEET    5 AA4 5 TYR C 268  VAL C 271 -1  O  VAL C 271   N  ALA B 104           
SHEET    1 AA5 3 ILE C 277  VAL C 280  0                                        
SHEET    2 AA5 3 ILE C 385  ILE C 389  1  O  VAL C 387   N  ILE C 278           
SHEET    3 AA5 3 ILE C 432  LEU C 434  1  O  ILE C 432   N  TYR C 388           
SHEET    1 AA6 2 ILE C 309  VAL C 314  0                                        
SHEET    2 AA6 2 LEU C 363  ALA C 368  1  O  ASP C 367   N  VAL C 314           
SHEET    1 AA7 5 LYS E  78  SER E  81  0                                        
SHEET    2 AA7 5 ILE E  56  LYS E  59 -1  N  THR E  58   O  ASN E  79           
SHEET    3 AA7 5 ALA E  48  HIS E  50 -1  N  ALA E  48   O  LYS E  59           
SHEET    4 AA7 5 ALA E  33  SER E  36 -1  N  LEU E  35   O  ALA E  49           
SHEET    5 AA7 5 GLU E 175  TYR E 178 -1  O  GLU E 175   N  SER E  36           
SHEET    1 AA8 2 GLU F  73  PRO F  74  0                                        
SHEET    2 AA8 2 TYR F 632  TYR F 633 -1  O  TYR F 633   N  GLU F  73           
SHEET    1 AA9 2 ILE F 152  ASP F 153  0                                        
SHEET    2 AA9 2 GLN F 160  VAL F 161 -1  O  VAL F 161   N  ILE F 152           
SHEET    1 AB1 5 ALA F 217  TYR F 219  0                                        
SHEET    2 AB1 5 GLN F 208  GLY F 211 -1  N  PHE F 210   O  ARG F 218           
SHEET    3 AB1 5 GLY F 488  SER F 495 -1  O  GLY F 491   N  VAL F 209           
SHEET    4 AB1 5 LEU F 460  VAL F 468 -1  N  VAL F 468   O  GLY F 488           
SHEET    5 AB1 5 GLN F 447  TRP F 448 -1  N  GLN F 447   O  THR F 465           
SHEET    1 AB2 5 ALA F 217  TYR F 219  0                                        
SHEET    2 AB2 5 GLN F 208  GLY F 211 -1  N  PHE F 210   O  ARG F 218           
SHEET    3 AB2 5 GLY F 488  SER F 495 -1  O  GLY F 491   N  VAL F 209           
SHEET    4 AB2 5 LEU F 460  VAL F 468 -1  N  VAL F 468   O  GLY F 488           
SHEET    5 AB2 5 TYR F 452  LEU F 453 -1  N  TYR F 452   O  VAL F 461           
SHEET    1 AB3 3 LYS F 254  ASP F 255  0                                        
SHEET    2 AB3 3 ASN F 357  LEU F 362  1  O  ILE F 359   N  ASP F 255           
SHEET    3 AB3 3 ILE F 258  LEU F 259  1  N  LEU F 259   O  MET F 361           
SHEET    1 AB4 4 LYS F 254  ASP F 255  0                                        
SHEET    2 AB4 4 ASN F 357  LEU F 362  1  O  ILE F 359   N  ASP F 255           
SHEET    3 AB4 4 ARG F 385  VAL F 391  1  O  PHE F 387   N  ILE F 360           
SHEET    4 AB4 4 TYR F 413  ILE F 415  1  O  ILE F 415   N  SER F 390           
SHEET    1 AB5 2 GLU F 587  LYS F 595  0                                        
SHEET    2 AB5 2 ILE F 602  THR F 610 -1  O  ASP F 603   N  VAL F 594           
SHEET    1 AB6 2 THR F 612  PRO F 613  0                                        
SHEET    2 AB6 2 SER F 621  LEU F 622 -1  O  LEU F 622   N  THR F 612           
SHEET    1 AB7 5 TYR F 661  LEU F 664  0                                        
SHEET    2 AB7 5 ILE F 743  VAL F 746 -1  O  THR F 744   N  PHE F 663           
SHEET    3 AB7 5 ALA F 734  THR F 739 -1  N  VAL F 737   O  ARG F 745           
SHEET    4 AB7 5 ALA F 813  ILE F 819 -1  O  GLY F 816   N  PHE F 736           
SHEET    5 AB7 5 ILE F 795  MET F 796 -1  N  ILE F 795   O  ILE F 819           
SHEET    1 AB8 5 TYR F 661  LEU F 664  0                                        
SHEET    2 AB8 5 ILE F 743  VAL F 746 -1  O  THR F 744   N  PHE F 663           
SHEET    3 AB8 5 ALA F 734  THR F 739 -1  N  VAL F 737   O  ARG F 745           
SHEET    4 AB8 5 ALA F 813  ILE F 819 -1  O  GLY F 816   N  PHE F 736           
SHEET    5 AB8 5 LYS F 799  ALA F 800 -1  N  LYS F 799   O  VAL F 815           
SHEET    1 AB9 5 LEU F 862  ALA F 865  0                                        
SHEET    2 AB9 5 ASP F 852  LEU F 856 -1  N  ILE F 855   O  MET F 864           
SHEET    3 AB9 5 ILE F1017  GLU F1022 -1  O  ILE F1017   N  LEU F 856           
SHEET    4 AB9 5 SER F1003  LYS F1010 -1  N  GLU F1009   O  PHE F1018           
SHEET    5 AB9 5 PHE F 993  ASP F 998 -1  N  PHE F 993   O  VAL F1008           
SHEET    1 AC1 2 ALA F 896  ASP F 902  0                                        
SHEET    2 AC1 2 THR F 979  PHE F 985 -1  O  THR F 979   N  ASP F 902           
SHEET    1 AC2 2 VAL F 906  CYS F 907  0                                        
SHEET    2 AC2 2 GLN F 975  SER F 976 -1  O  GLN F 975   N  CYS F 907           
SSBOND   1 CYS A  226    CYS A  254                          1555   1555  2.10  
SSBOND   2 CYS A  245    CYS A  261                          1555   1555  2.01  
SSBOND   3 CYS A  957    CYS A  968                          1555   1555  2.04  
SSBOND   4 CYS A 1338    CYS A 1352                          1555   1555  2.04  
SSBOND   5 CYS E   57    CYS E   80                          1555   1555  2.04  
SSBOND   6 CYS F  305    CYS F 1047                          1555   1555  2.04  
SSBOND   7 CYS F  356    CYS F 1062                          1555   1555  2.04  
SSBOND   8 CYS F  406    CYS F 1074                          1555   1555  2.01  
SSBOND   9 CYS F  907    CYS F  977                          1555   1555  2.03  
SSBOND  10 CYS F  999    CYS F 1029                          1555   1555  2.03  
SSBOND  11 CYS F 1002    CYS F 1027                          1555   1555  2.03  
LINK         ND2 ASN A 257                 C1  NAG A1901     1555   1555  1.46  
LINK         ND2 ASN F  94                 C1  NAG F1214     1555   1555  1.45  
LINK         ND2 ASN F 186                 C1  NAG F1210     1555   1555  1.43  
LINK         ND2 ASN F 326                 C1  NAG F1204     1555   1555  1.44  
LINK         ND2 ASN F 350                 C1  NAG F1202     1555   1555  1.44  
LINK         ND2 ASN F 470                 C1  NAG F1211     1555   1555  1.43  
LINK         ND2 ASN F 606                 C1  NAG F1215     1555   1555  1.43  
LINK         ND2 ASN F 615                 C1  NAG F1205     1555   1555  1.44  
LINK         ND2 ASN F 678                 C1  NAG F1218     1555   1555  1.45  
LINK         ND2 ASN F 784                 C1  NAG F1220     1555   1555  1.44  
LINK         ND2 ASN F 827                 C1  NAG F1225     1555   1555  1.46  
LINK         ND2 ASN F 891                 C1  NAG F1207     1555   1555  1.44  
LINK         ND2 ASN F 898                 C1  NAG F1216     1555   1555  1.45  
LINK         ND2 ASN F 988                 C1  NAG F1222     1555   1555  1.44  
LINK         ND2 ASN F1001                 C1  NAG F1221     1555   1555  1.45  
LINK         C   CYS F1074                 N   ETA F1075     1555   1555  1.39  
LINK         O4  NAG F1202                 C1  NAG F1203     1555   1555  1.45  
LINK         O4  NAG F1205                 C1  NAG F1206     1555   1555  1.46  
LINK         C1  BMA F1208                 O4  NAG F1209     1555   1555  1.44  
LINK         C1  NAG F1209                 O4  NAG F1210     1555   1555  1.44  
LINK         O4  NAG F1211                 C1  NAG F1212     1555   1555  1.45  
LINK         O4  NAG F1212                 C1  BMA F1213     1555   1555  1.45  
LINK         O4  NAG F1216                 C1  NAG F1217     1555   1555  1.43  
LINK         O4  NAG F1218                 C1  NAG F1219     1555   1555  1.45  
LINK         C1  NAG F1223                 O4  NAG F1224     1555   1555  1.44  
LINK         C1  NAG F1224                 O4  NAG F1225     1555   1555  1.43  
CISPEP   1 CYS A 1439    PRO A 1440          0       -28.92                     
SITE     1 AC1  5 GLU A 292  GLU A 614  GLU A1014  GLY A1322                    
SITE     2 AC1  5  CA A1903                                                     
SITE     1 AC2  1  CA A1902                                                     
SITE     1 AC3  4 ASP A  78  SER F 263  SER F 265  THR F 333                    
SITE     1 AC4  1 ASN A 257                                                     
SITE     1 AC5  1 ASN F  94                                                     
SITE     1 AC6  4 ARG F 116  SER F 121  ASN F 186  SER F 189                    
SITE     1 AC7  1 ASN F 326                                                     
SITE     1 AC8  1 ASN F 350                                                     
SITE     1 AC9  3 GLN F 110  TRP F 115  ASN F 470                               
SITE     1 AD1  2 ARG F 591  ASN F 606                                          
SITE     1 AD2  2 GLU F  82  ASN F 615                                          
SITE     1 AD3  2 ASN F 678  GLU F 681                                          
SITE     1 AD4  3 PHE F 783  ASN F 784  ARG F 876                               
SITE     1 AD5  5 ASP F  45  LEU F  49  THR F  52  ILE F 729                    
SITE     2 AD5  5 ASN F 827                                                     
SITE     1 AD6  1 ASN F 891                                                     
SITE     1 AD7  3 LEU F 593  ASN F 898  PHE F 985                               
SITE     1 AD8  2 ILE F 892  ASN F 988                                          
SITE     1 AD9  2 ASN F1001  CYS F1027                                          
CRYST1  337.920  337.920  337.920  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.002959  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.002959  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.002959        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system