HEADER TRANSPORT PROTEIN 04-DEC-16 5MKE
TITLE CRYOEM STRUCTURE OF POLYCYSTIN-2 IN COMPLEX WITH CATIONS AND LIPIDS
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: POLYCYSTIN-2;
COMPND 3 CHAIN: A, B, C, D;
COMPND 4 SYNONYM: AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE TYPE II
COMPND 5 PROTEIN,POLYCYSTIC KIDNEY DISEASE 2 PROTEIN,POLYCYSTWIN,R48321,
COMPND 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY P MEMBER 2;
COMPND 7 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: PKD2, TRPP2;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN;
SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 9 EXPRESSION_SYSTEM_CELL_LINE: HEK293
KEYWDS CA2+ SIGNALING, CRYOEM, MEMBRANE PROTEIN STRUCTURE, POLYCYSTIN-2, TRP
KEYWDS 2 CHANNEL, TRANSPORT PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR M.WILKES,M.G.MADEJ,C.ZIEGLER
REVDAT 5 29-JUL-20 5MKE 1 COMPND REMARK HETNAM LINK
REVDAT 5 2 1 SITE ATOM
REVDAT 4 11-DEC-19 5MKE 1 REMARK CRYST1 SCALE
REVDAT 3 15-FEB-17 5MKE 1 JRNL
REVDAT 2 25-JAN-17 5MKE 1 SOURCE JRNL
REVDAT 1 18-JAN-17 5MKE 0
JRNL AUTH M.WILKES,M.G.MADEJ,L.KREUTER,D.RHINOW,V.HEINZ,S.DE SANCTIS,
JRNL AUTH 2 S.RUPPEL,R.M.RICHTER,F.JOOS,M.GRIEBEN,A.C.PIKE,
JRNL AUTH 3 J.T.HUISKONEN,E.P.CARPENTER,W.KUHLBRANDT,R.WITZGALL,
JRNL AUTH 4 C.ZIEGLER
JRNL TITL MOLECULAR INSIGHTS INTO LIPID-ASSISTED CA(2+) REGULATION OF
JRNL TITL 2 THE TRP CHANNEL POLYCYSTIN-2.
JRNL REF NAT. STRUCT. MOL. BIOL. V. 24 123 2017
JRNL REFN ESSN 1545-9985
JRNL PMID 28092368
JRNL DOI 10.1038/NSMB.3357
REMARK 2
REMARK 2 RESOLUTION. 4.30 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : NULL
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : WE USED FOR COMPARATIVE STRUCTURE MODELING
REMARK 3 TRPA1 (PDB ENTRY CODE 3J9P) AS TEMPLATE FOR S1 AND S3-S5, TRPV1
REMARK 3 (PDB ENTRY CODE 3J5Q) FOR S5-S6, AND THE TRPV2 (PDB ENTRY CODE
REMARK 3 5AN8) FITTED BEST FOR S2-S3 TO OBTAIN AN INITIAL MODEL. THE
REMARK 3 SOLUBLE DOMAIN WAS BUILD BASED ON PDBID: 5K47. BUT WE HAD NO
REMARK 3 SEARCH MODEL FOR MOLECULAR REPLACEMENT. ALTHOUGH WE HAD A GOOD
REMARK 3 IDEA WHAT THE ARCHITECTURE WOULD BE LIKE, WE BUILD THE MODEL DE
REMARK 3 NOVO WITH COOT.
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.300
REMARK 3 NUMBER OF PARTICLES : 42268
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 5MKE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 05-DEC-16.
REMARK 100 THE DEPOSITION ID IS D_1200002521.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : POLYCYSTIN-2
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : JEOL 3200FSC
REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 4.10
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 1.80
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 42440 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 93020 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -165.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 VAL A 2
REMARK 465 ASN A 3
REMARK 465 SER A 4
REMARK 465 SER A 5
REMARK 465 ARG A 6
REMARK 465 VAL A 7
REMARK 465 GLN A 8
REMARK 465 PRO A 9
REMARK 465 GLN A 10
REMARK 465 GLN A 11
REMARK 465 PRO A 12
REMARK 465 GLY A 13
REMARK 465 ASP A 14
REMARK 465 ALA A 15
REMARK 465 LYS A 16
REMARK 465 ARG A 17
REMARK 465 PRO A 18
REMARK 465 PRO A 19
REMARK 465 ALA A 20
REMARK 465 PRO A 21
REMARK 465 ARG A 22
REMARK 465 ALA A 23
REMARK 465 PRO A 24
REMARK 465 ASP A 25
REMARK 465 PRO A 26
REMARK 465 GLY A 27
REMARK 465 ARG A 28
REMARK 465 LEU A 29
REMARK 465 MET A 30
REMARK 465 ALA A 31
REMARK 465 GLY A 32
REMARK 465 CYS A 33
REMARK 465 ALA A 34
REMARK 465 ALA A 35
REMARK 465 VAL A 36
REMARK 465 GLY A 37
REMARK 465 ALA A 38
REMARK 465 SER A 39
REMARK 465 LEU A 40
REMARK 465 ALA A 41
REMARK 465 ALA A 42
REMARK 465 PRO A 43
REMARK 465 GLY A 44
REMARK 465 GLY A 45
REMARK 465 LEU A 46
REMARK 465 CYS A 47
REMARK 465 GLU A 48
REMARK 465 GLN A 49
REMARK 465 ARG A 50
REMARK 465 GLY A 51
REMARK 465 LEU A 52
REMARK 465 GLU A 53
REMARK 465 ILE A 54
REMARK 465 GLU A 55
REMARK 465 MET A 56
REMARK 465 GLN A 57
REMARK 465 ARG A 58
REMARK 465 ILE A 59
REMARK 465 ARG A 60
REMARK 465 GLN A 61
REMARK 465 ALA A 62
REMARK 465 ALA A 63
REMARK 465 ALA A 64
REMARK 465 ARG A 65
REMARK 465 ASP A 66
REMARK 465 PRO A 67
REMARK 465 PRO A 68
REMARK 465 ALA A 69
REMARK 465 GLY A 70
REMARK 465 ALA A 71
REMARK 465 ALA A 72
REMARK 465 ALA A 73
REMARK 465 SER A 74
REMARK 465 PRO A 75
REMARK 465 SER A 76
REMARK 465 PRO A 77
REMARK 465 PRO A 78
REMARK 465 LEU A 79
REMARK 465 SER A 80
REMARK 465 SER A 81
REMARK 465 CYS A 82
REMARK 465 SER A 83
REMARK 465 ARG A 84
REMARK 465 GLN A 85
REMARK 465 ALA A 86
REMARK 465 TRP A 87
REMARK 465 SER A 88
REMARK 465 ARG A 89
REMARK 465 ASP A 90
REMARK 465 ASN A 91
REMARK 465 PRO A 92
REMARK 465 GLY A 93
REMARK 465 PHE A 94
REMARK 465 GLU A 95
REMARK 465 ALA A 96
REMARK 465 GLU A 97
REMARK 465 GLU A 98
REMARK 465 GLU A 99
REMARK 465 GLU A 100
REMARK 465 GLU A 101
REMARK 465 GLU A 102
REMARK 465 VAL A 103
REMARK 465 GLU A 104
REMARK 465 GLY A 105
REMARK 465 GLU A 106
REMARK 465 GLU A 107
REMARK 465 GLY A 108
REMARK 465 GLY A 109
REMARK 465 MET A 110
REMARK 465 VAL A 111
REMARK 465 VAL A 112
REMARK 465 GLU A 113
REMARK 465 MET A 114
REMARK 465 ASP A 115
REMARK 465 VAL A 116
REMARK 465 GLU A 117
REMARK 465 TRP A 118
REMARK 465 ARG A 119
REMARK 465 PRO A 120
REMARK 465 GLY A 121
REMARK 465 SER A 122
REMARK 465 ARG A 123
REMARK 465 ARG A 124
REMARK 465 SER A 125
REMARK 465 ALA A 126
REMARK 465 ALA A 127
REMARK 465 SER A 128
REMARK 465 SER A 129
REMARK 465 ALA A 130
REMARK 465 VAL A 131
REMARK 465 SER A 132
REMARK 465 SER A 133
REMARK 465 VAL A 134
REMARK 465 GLY A 135
REMARK 465 ALA A 136
REMARK 465 ARG A 137
REMARK 465 SER A 138
REMARK 465 ARG A 139
REMARK 465 GLY A 140
REMARK 465 LEU A 141
REMARK 465 GLY A 142
REMARK 465 GLY A 143
REMARK 465 TYR A 144
REMARK 465 HIS A 145
REMARK 465 GLY A 146
REMARK 465 ALA A 147
REMARK 465 GLY A 148
REMARK 465 HIS A 149
REMARK 465 PRO A 150
REMARK 465 SER A 151
REMARK 465 GLY A 152
REMARK 465 ARG A 153
REMARK 465 ARG A 154
REMARK 465 ARG A 155
REMARK 465 ARG A 156
REMARK 465 ARG A 157
REMARK 465 GLU A 158
REMARK 465 ASP A 159
REMARK 465 GLN A 160
REMARK 465 GLY A 161
REMARK 465 PRO A 162
REMARK 465 PRO A 163
REMARK 465 CYS A 164
REMARK 465 PRO A 165
REMARK 465 SER A 166
REMARK 465 PRO A 167
REMARK 465 VAL A 168
REMARK 465 GLY A 169
REMARK 465 GLY A 170
REMARK 465 GLY A 171
REMARK 465 ASP A 172
REMARK 465 PRO A 173
REMARK 465 LEU A 174
REMARK 465 HIS A 175
REMARK 465 ARG A 176
REMARK 465 HIS A 177
REMARK 465 LEU A 178
REMARK 465 PRO A 179
REMARK 465 LEU A 180
REMARK 465 GLU A 181
REMARK 465 GLY A 182
REMARK 465 GLN A 183
REMARK 465 PRO A 184
REMARK 465 PRO A 185
REMARK 465 ARG A 186
REMARK 465 VAL A 187
REMARK 465 ALA A 188
REMARK 465 TRP A 189
REMARK 465 ALA A 190
REMARK 465 GLU A 191
REMARK 465 ARG A 192
REMARK 465 LEU A 193
REMARK 465 VAL A 194
REMARK 465 ARG A 195
REMARK 465 GLY A 196
REMARK 465 LEU A 197
REMARK 465 ARG A 198
REMARK 465 GLY A 199
REMARK 465 LEU A 200
REMARK 465 TRP A 201
REMARK 465 GLY A 202
REMARK 465 THR A 203
REMARK 465 ARG A 204
REMARK 465 LEU A 205
REMARK 465 MET A 206
REMARK 465 GLU A 207
REMARK 465 GLU A 208
REMARK 465 SER A 209
REMARK 465 SER A 210
REMARK 465 THR A 211
REMARK 465 ASN A 212
REMARK 465 ARG A 213
REMARK 465 GLU A 214
REMARK 465 SER A 298
REMARK 465 ASN A 299
REMARK 465 GLN A 300
REMARK 465 THR A 301
REMARK 465 GLU A 302
REMARK 465 ALA A 303
REMARK 465 ALA A 696
REMARK 465 GLU A 697
REMARK 465 MET A 698
REMARK 465 GLU A 699
REMARK 465 LEU A 700
REMARK 465 SER A 701
REMARK 465 ASP A 702
REMARK 465 LEU A 703
REMARK 465 ILE A 704
REMARK 465 ARG A 705
REMARK 465 LYS A 706
REMARK 465 GLY A 707
REMARK 465 TYR A 708
REMARK 465 HIS A 709
REMARK 465 LYS A 710
REMARK 465 ALA A 711
REMARK 465 LEU A 712
REMARK 465 VAL A 713
REMARK 465 LYS A 714
REMARK 465 LEU A 715
REMARK 465 LYS A 716
REMARK 465 LEU A 717
REMARK 465 LYS A 718
REMARK 465 LYS A 719
REMARK 465 ASN A 720
REMARK 465 THR A 721
REMARK 465 VAL A 722
REMARK 465 ASP A 723
REMARK 465 ASP A 724
REMARK 465 ILE A 725
REMARK 465 SER A 726
REMARK 465 GLU A 727
REMARK 465 SER A 728
REMARK 465 LEU A 729
REMARK 465 ARG A 730
REMARK 465 GLN A 731
REMARK 465 GLY A 732
REMARK 465 GLY A 733
REMARK 465 GLY A 734
REMARK 465 LYS A 735
REMARK 465 LEU A 736
REMARK 465 ASN A 737
REMARK 465 PHE A 738
REMARK 465 ASP A 739
REMARK 465 GLU A 740
REMARK 465 LEU A 741
REMARK 465 ARG A 742
REMARK 465 GLN A 743
REMARK 465 ASP A 744
REMARK 465 LEU A 745
REMARK 465 LYS A 746
REMARK 465 GLY A 747
REMARK 465 LYS A 748
REMARK 465 GLY A 749
REMARK 465 HIS A 750
REMARK 465 THR A 751
REMARK 465 ASP A 752
REMARK 465 ALA A 753
REMARK 465 GLU A 754
REMARK 465 ILE A 755
REMARK 465 GLU A 756
REMARK 465 ALA A 757
REMARK 465 ILE A 758
REMARK 465 PHE A 759
REMARK 465 THR A 760
REMARK 465 LYS A 761
REMARK 465 TYR A 762
REMARK 465 ASP A 763
REMARK 465 GLN A 764
REMARK 465 ASP A 765
REMARK 465 GLY A 766
REMARK 465 ASP A 767
REMARK 465 GLN A 768
REMARK 465 GLU A 769
REMARK 465 LEU A 770
REMARK 465 THR A 771
REMARK 465 GLU A 772
REMARK 465 HIS A 773
REMARK 465 GLU A 774
REMARK 465 HIS A 775
REMARK 465 GLN A 776
REMARK 465 GLN A 777
REMARK 465 MET A 778
REMARK 465 ARG A 779
REMARK 465 ASP A 780
REMARK 465 ASP A 781
REMARK 465 LEU A 782
REMARK 465 GLU A 783
REMARK 465 LYS A 784
REMARK 465 GLU A 785
REMARK 465 ARG A 786
REMARK 465 GLU A 787
REMARK 465 ASP A 788
REMARK 465 LEU A 789
REMARK 465 ASP A 790
REMARK 465 LEU A 791
REMARK 465 ASP A 792
REMARK 465 HIS A 793
REMARK 465 SER A 794
REMARK 465 SER A 795
REMARK 465 LEU A 796
REMARK 465 PRO A 797
REMARK 465 ARG A 798
REMARK 465 PRO A 799
REMARK 465 MET A 800
REMARK 465 SER A 801
REMARK 465 SER A 802
REMARK 465 ARG A 803
REMARK 465 SER A 804
REMARK 465 PHE A 805
REMARK 465 PRO A 806
REMARK 465 ARG A 807
REMARK 465 SER A 808
REMARK 465 LEU A 809
REMARK 465 ASP A 810
REMARK 465 ASP A 811
REMARK 465 SER A 812
REMARK 465 GLU A 813
REMARK 465 GLU A 814
REMARK 465 ASP A 815
REMARK 465 ASP A 816
REMARK 465 ASP A 817
REMARK 465 GLU A 818
REMARK 465 ASP A 819
REMARK 465 SER A 820
REMARK 465 GLY A 821
REMARK 465 HIS A 822
REMARK 465 SER A 823
REMARK 465 SER A 824
REMARK 465 ARG A 825
REMARK 465 ARG A 826
REMARK 465 ARG A 827
REMARK 465 GLY A 828
REMARK 465 SER A 829
REMARK 465 ILE A 830
REMARK 465 SER A 831
REMARK 465 SER A 832
REMARK 465 GLY A 833
REMARK 465 VAL A 834
REMARK 465 SER A 835
REMARK 465 TYR A 836
REMARK 465 GLU A 837
REMARK 465 GLU A 838
REMARK 465 PHE A 839
REMARK 465 GLN A 840
REMARK 465 VAL A 841
REMARK 465 LEU A 842
REMARK 465 VAL A 843
REMARK 465 ARG A 844
REMARK 465 ARG A 845
REMARK 465 VAL A 846
REMARK 465 ASP A 847
REMARK 465 ARG A 848
REMARK 465 MET A 849
REMARK 465 GLU A 850
REMARK 465 HIS A 851
REMARK 465 SER A 852
REMARK 465 ILE A 853
REMARK 465 GLY A 854
REMARK 465 SER A 855
REMARK 465 ILE A 856
REMARK 465 VAL A 857
REMARK 465 SER A 858
REMARK 465 LYS A 859
REMARK 465 ILE A 860
REMARK 465 ASP A 861
REMARK 465 ALA A 862
REMARK 465 VAL A 863
REMARK 465 ILE A 864
REMARK 465 VAL A 865
REMARK 465 LYS A 866
REMARK 465 LEU A 867
REMARK 465 GLU A 868
REMARK 465 ILE A 869
REMARK 465 MET A 870
REMARK 465 GLU A 871
REMARK 465 ARG A 872
REMARK 465 ALA A 873
REMARK 465 LYS A 874
REMARK 465 LEU A 875
REMARK 465 LYS A 876
REMARK 465 ARG A 877
REMARK 465 ARG A 878
REMARK 465 GLU A 879
REMARK 465 VAL A 880
REMARK 465 LEU A 881
REMARK 465 GLY A 882
REMARK 465 ARG A 883
REMARK 465 LEU A 884
REMARK 465 LEU A 885
REMARK 465 ASP A 886
REMARK 465 GLY A 887
REMARK 465 VAL A 888
REMARK 465 ALA A 889
REMARK 465 GLU A 890
REMARK 465 ASP A 891
REMARK 465 GLU A 892
REMARK 465 ARG A 893
REMARK 465 LEU A 894
REMARK 465 GLY A 895
REMARK 465 ARG A 896
REMARK 465 ASP A 897
REMARK 465 SER A 898
REMARK 465 GLU A 899
REMARK 465 ILE A 900
REMARK 465 HIS A 901
REMARK 465 ARG A 902
REMARK 465 GLU A 903
REMARK 465 GLN A 904
REMARK 465 MET A 905
REMARK 465 GLU A 906
REMARK 465 ARG A 907
REMARK 465 LEU A 908
REMARK 465 VAL A 909
REMARK 465 ARG A 910
REMARK 465 GLU A 911
REMARK 465 GLU A 912
REMARK 465 LEU A 913
REMARK 465 GLU A 914
REMARK 465 ARG A 915
REMARK 465 TRP A 916
REMARK 465 GLU A 917
REMARK 465 SER A 918
REMARK 465 ASP A 919
REMARK 465 ASP A 920
REMARK 465 ALA A 921
REMARK 465 ALA A 922
REMARK 465 SER A 923
REMARK 465 GLN A 924
REMARK 465 ILE A 925
REMARK 465 SER A 926
REMARK 465 HIS A 927
REMARK 465 GLY A 928
REMARK 465 LEU A 929
REMARK 465 GLY A 930
REMARK 465 THR A 931
REMARK 465 PRO A 932
REMARK 465 VAL A 933
REMARK 465 GLY A 934
REMARK 465 LEU A 935
REMARK 465 ASN A 936
REMARK 465 GLY A 937
REMARK 465 GLN A 938
REMARK 465 PRO A 939
REMARK 465 ARG A 940
REMARK 465 PRO A 941
REMARK 465 ARG A 942
REMARK 465 SER A 943
REMARK 465 SER A 944
REMARK 465 ARG A 945
REMARK 465 PRO A 946
REMARK 465 SER A 947
REMARK 465 SER A 948
REMARK 465 SER A 949
REMARK 465 GLN A 950
REMARK 465 SER A 951
REMARK 465 THR A 952
REMARK 465 GLU A 953
REMARK 465 GLY A 954
REMARK 465 MET A 955
REMARK 465 GLU A 956
REMARK 465 GLY A 957
REMARK 465 ALA A 958
REMARK 465 GLY A 959
REMARK 465 GLY A 960
REMARK 465 ASN A 961
REMARK 465 GLY A 962
REMARK 465 SER A 963
REMARK 465 SER A 964
REMARK 465 ASN A 965
REMARK 465 VAL A 966
REMARK 465 HIS A 967
REMARK 465 VAL A 968
REMARK 465 MET B 1
REMARK 465 VAL B 2
REMARK 465 ASN B 3
REMARK 465 SER B 4
REMARK 465 SER B 5
REMARK 465 ARG B 6
REMARK 465 VAL B 7
REMARK 465 GLN B 8
REMARK 465 PRO B 9
REMARK 465 GLN B 10
REMARK 465 GLN B 11
REMARK 465 PRO B 12
REMARK 465 GLY B 13
REMARK 465 ASP B 14
REMARK 465 ALA B 15
REMARK 465 LYS B 16
REMARK 465 ARG B 17
REMARK 465 PRO B 18
REMARK 465 PRO B 19
REMARK 465 ALA B 20
REMARK 465 PRO B 21
REMARK 465 ARG B 22
REMARK 465 ALA B 23
REMARK 465 PRO B 24
REMARK 465 ASP B 25
REMARK 465 PRO B 26
REMARK 465 GLY B 27
REMARK 465 ARG B 28
REMARK 465 LEU B 29
REMARK 465 MET B 30
REMARK 465 ALA B 31
REMARK 465 GLY B 32
REMARK 465 CYS B 33
REMARK 465 ALA B 34
REMARK 465 ALA B 35
REMARK 465 VAL B 36
REMARK 465 GLY B 37
REMARK 465 ALA B 38
REMARK 465 SER B 39
REMARK 465 LEU B 40
REMARK 465 ALA B 41
REMARK 465 ALA B 42
REMARK 465 PRO B 43
REMARK 465 GLY B 44
REMARK 465 GLY B 45
REMARK 465 LEU B 46
REMARK 465 CYS B 47
REMARK 465 GLU B 48
REMARK 465 GLN B 49
REMARK 465 ARG B 50
REMARK 465 GLY B 51
REMARK 465 LEU B 52
REMARK 465 GLU B 53
REMARK 465 ILE B 54
REMARK 465 GLU B 55
REMARK 465 MET B 56
REMARK 465 GLN B 57
REMARK 465 ARG B 58
REMARK 465 ILE B 59
REMARK 465 ARG B 60
REMARK 465 GLN B 61
REMARK 465 ALA B 62
REMARK 465 ALA B 63
REMARK 465 ALA B 64
REMARK 465 ARG B 65
REMARK 465 ASP B 66
REMARK 465 PRO B 67
REMARK 465 PRO B 68
REMARK 465 ALA B 69
REMARK 465 GLY B 70
REMARK 465 ALA B 71
REMARK 465 ALA B 72
REMARK 465 ALA B 73
REMARK 465 SER B 74
REMARK 465 PRO B 75
REMARK 465 SER B 76
REMARK 465 PRO B 77
REMARK 465 PRO B 78
REMARK 465 LEU B 79
REMARK 465 SER B 80
REMARK 465 SER B 81
REMARK 465 CYS B 82
REMARK 465 SER B 83
REMARK 465 ARG B 84
REMARK 465 GLN B 85
REMARK 465 ALA B 86
REMARK 465 TRP B 87
REMARK 465 SER B 88
REMARK 465 ARG B 89
REMARK 465 ASP B 90
REMARK 465 ASN B 91
REMARK 465 PRO B 92
REMARK 465 GLY B 93
REMARK 465 PHE B 94
REMARK 465 GLU B 95
REMARK 465 ALA B 96
REMARK 465 GLU B 97
REMARK 465 GLU B 98
REMARK 465 GLU B 99
REMARK 465 GLU B 100
REMARK 465 GLU B 101
REMARK 465 GLU B 102
REMARK 465 VAL B 103
REMARK 465 GLU B 104
REMARK 465 GLY B 105
REMARK 465 GLU B 106
REMARK 465 GLU B 107
REMARK 465 GLY B 108
REMARK 465 GLY B 109
REMARK 465 MET B 110
REMARK 465 VAL B 111
REMARK 465 VAL B 112
REMARK 465 GLU B 113
REMARK 465 MET B 114
REMARK 465 ASP B 115
REMARK 465 VAL B 116
REMARK 465 GLU B 117
REMARK 465 TRP B 118
REMARK 465 ARG B 119
REMARK 465 PRO B 120
REMARK 465 GLY B 121
REMARK 465 SER B 122
REMARK 465 ARG B 123
REMARK 465 ARG B 124
REMARK 465 SER B 125
REMARK 465 ALA B 126
REMARK 465 ALA B 127
REMARK 465 SER B 128
REMARK 465 SER B 129
REMARK 465 ALA B 130
REMARK 465 VAL B 131
REMARK 465 SER B 132
REMARK 465 SER B 133
REMARK 465 VAL B 134
REMARK 465 GLY B 135
REMARK 465 ALA B 136
REMARK 465 ARG B 137
REMARK 465 SER B 138
REMARK 465 ARG B 139
REMARK 465 GLY B 140
REMARK 465 LEU B 141
REMARK 465 GLY B 142
REMARK 465 GLY B 143
REMARK 465 TYR B 144
REMARK 465 HIS B 145
REMARK 465 GLY B 146
REMARK 465 ALA B 147
REMARK 465 GLY B 148
REMARK 465 HIS B 149
REMARK 465 PRO B 150
REMARK 465 SER B 151
REMARK 465 GLY B 152
REMARK 465 ARG B 153
REMARK 465 ARG B 154
REMARK 465 ARG B 155
REMARK 465 ARG B 156
REMARK 465 ARG B 157
REMARK 465 GLU B 158
REMARK 465 ASP B 159
REMARK 465 GLN B 160
REMARK 465 GLY B 161
REMARK 465 PRO B 162
REMARK 465 PRO B 163
REMARK 465 CYS B 164
REMARK 465 PRO B 165
REMARK 465 SER B 166
REMARK 465 PRO B 167
REMARK 465 VAL B 168
REMARK 465 GLY B 169
REMARK 465 GLY B 170
REMARK 465 GLY B 171
REMARK 465 ASP B 172
REMARK 465 PRO B 173
REMARK 465 LEU B 174
REMARK 465 HIS B 175
REMARK 465 ARG B 176
REMARK 465 HIS B 177
REMARK 465 LEU B 178
REMARK 465 PRO B 179
REMARK 465 LEU B 180
REMARK 465 GLU B 181
REMARK 465 GLY B 182
REMARK 465 GLN B 183
REMARK 465 PRO B 184
REMARK 465 PRO B 185
REMARK 465 ARG B 186
REMARK 465 VAL B 187
REMARK 465 ALA B 188
REMARK 465 TRP B 189
REMARK 465 ALA B 190
REMARK 465 GLU B 191
REMARK 465 ARG B 192
REMARK 465 LEU B 193
REMARK 465 VAL B 194
REMARK 465 ARG B 195
REMARK 465 GLY B 196
REMARK 465 LEU B 197
REMARK 465 ARG B 198
REMARK 465 GLY B 199
REMARK 465 LEU B 200
REMARK 465 TRP B 201
REMARK 465 GLY B 202
REMARK 465 THR B 203
REMARK 465 ARG B 204
REMARK 465 LEU B 205
REMARK 465 MET B 206
REMARK 465 GLU B 207
REMARK 465 GLU B 208
REMARK 465 SER B 209
REMARK 465 SER B 210
REMARK 465 THR B 211
REMARK 465 ASN B 212
REMARK 465 ARG B 213
REMARK 465 GLU B 214
REMARK 465 SER B 298
REMARK 465 ASN B 299
REMARK 465 GLN B 300
REMARK 465 THR B 301
REMARK 465 GLU B 302
REMARK 465 ALA B 303
REMARK 465 ALA B 696
REMARK 465 GLU B 697
REMARK 465 MET B 698
REMARK 465 GLU B 699
REMARK 465 LEU B 700
REMARK 465 SER B 701
REMARK 465 ASP B 702
REMARK 465 LEU B 703
REMARK 465 ILE B 704
REMARK 465 ARG B 705
REMARK 465 LYS B 706
REMARK 465 GLY B 707
REMARK 465 TYR B 708
REMARK 465 HIS B 709
REMARK 465 LYS B 710
REMARK 465 ALA B 711
REMARK 465 LEU B 712
REMARK 465 VAL B 713
REMARK 465 LYS B 714
REMARK 465 LEU B 715
REMARK 465 LYS B 716
REMARK 465 LEU B 717
REMARK 465 LYS B 718
REMARK 465 LYS B 719
REMARK 465 ASN B 720
REMARK 465 THR B 721
REMARK 465 VAL B 722
REMARK 465 ASP B 723
REMARK 465 ASP B 724
REMARK 465 ILE B 725
REMARK 465 SER B 726
REMARK 465 GLU B 727
REMARK 465 SER B 728
REMARK 465 LEU B 729
REMARK 465 ARG B 730
REMARK 465 GLN B 731
REMARK 465 GLY B 732
REMARK 465 GLY B 733
REMARK 465 GLY B 734
REMARK 465 LYS B 735
REMARK 465 LEU B 736
REMARK 465 ASN B 737
REMARK 465 PHE B 738
REMARK 465 ASP B 739
REMARK 465 GLU B 740
REMARK 465 LEU B 741
REMARK 465 ARG B 742
REMARK 465 GLN B 743
REMARK 465 ASP B 744
REMARK 465 LEU B 745
REMARK 465 LYS B 746
REMARK 465 GLY B 747
REMARK 465 LYS B 748
REMARK 465 GLY B 749
REMARK 465 HIS B 750
REMARK 465 THR B 751
REMARK 465 ASP B 752
REMARK 465 ALA B 753
REMARK 465 GLU B 754
REMARK 465 ILE B 755
REMARK 465 GLU B 756
REMARK 465 ALA B 757
REMARK 465 ILE B 758
REMARK 465 PHE B 759
REMARK 465 THR B 760
REMARK 465 LYS B 761
REMARK 465 TYR B 762
REMARK 465 ASP B 763
REMARK 465 GLN B 764
REMARK 465 ASP B 765
REMARK 465 GLY B 766
REMARK 465 ASP B 767
REMARK 465 GLN B 768
REMARK 465 GLU B 769
REMARK 465 LEU B 770
REMARK 465 THR B 771
REMARK 465 GLU B 772
REMARK 465 HIS B 773
REMARK 465 GLU B 774
REMARK 465 HIS B 775
REMARK 465 GLN B 776
REMARK 465 GLN B 777
REMARK 465 MET B 778
REMARK 465 ARG B 779
REMARK 465 ASP B 780
REMARK 465 ASP B 781
REMARK 465 LEU B 782
REMARK 465 GLU B 783
REMARK 465 LYS B 784
REMARK 465 GLU B 785
REMARK 465 ARG B 786
REMARK 465 GLU B 787
REMARK 465 ASP B 788
REMARK 465 LEU B 789
REMARK 465 ASP B 790
REMARK 465 LEU B 791
REMARK 465 ASP B 792
REMARK 465 HIS B 793
REMARK 465 SER B 794
REMARK 465 SER B 795
REMARK 465 LEU B 796
REMARK 465 PRO B 797
REMARK 465 ARG B 798
REMARK 465 PRO B 799
REMARK 465 MET B 800
REMARK 465 SER B 801
REMARK 465 SER B 802
REMARK 465 ARG B 803
REMARK 465 SER B 804
REMARK 465 PHE B 805
REMARK 465 PRO B 806
REMARK 465 ARG B 807
REMARK 465 SER B 808
REMARK 465 LEU B 809
REMARK 465 ASP B 810
REMARK 465 ASP B 811
REMARK 465 SER B 812
REMARK 465 GLU B 813
REMARK 465 GLU B 814
REMARK 465 ASP B 815
REMARK 465 ASP B 816
REMARK 465 ASP B 817
REMARK 465 GLU B 818
REMARK 465 ASP B 819
REMARK 465 SER B 820
REMARK 465 GLY B 821
REMARK 465 HIS B 822
REMARK 465 SER B 823
REMARK 465 SER B 824
REMARK 465 ARG B 825
REMARK 465 ARG B 826
REMARK 465 ARG B 827
REMARK 465 GLY B 828
REMARK 465 SER B 829
REMARK 465 ILE B 830
REMARK 465 SER B 831
REMARK 465 SER B 832
REMARK 465 GLY B 833
REMARK 465 VAL B 834
REMARK 465 SER B 835
REMARK 465 TYR B 836
REMARK 465 GLU B 837
REMARK 465 GLU B 838
REMARK 465 PHE B 839
REMARK 465 GLN B 840
REMARK 465 VAL B 841
REMARK 465 LEU B 842
REMARK 465 VAL B 843
REMARK 465 ARG B 844
REMARK 465 ARG B 845
REMARK 465 VAL B 846
REMARK 465 ASP B 847
REMARK 465 ARG B 848
REMARK 465 MET B 849
REMARK 465 GLU B 850
REMARK 465 HIS B 851
REMARK 465 SER B 852
REMARK 465 ILE B 853
REMARK 465 GLY B 854
REMARK 465 SER B 855
REMARK 465 ILE B 856
REMARK 465 VAL B 857
REMARK 465 SER B 858
REMARK 465 LYS B 859
REMARK 465 ILE B 860
REMARK 465 ASP B 861
REMARK 465 ALA B 862
REMARK 465 VAL B 863
REMARK 465 ILE B 864
REMARK 465 VAL B 865
REMARK 465 LYS B 866
REMARK 465 LEU B 867
REMARK 465 GLU B 868
REMARK 465 ILE B 869
REMARK 465 MET B 870
REMARK 465 GLU B 871
REMARK 465 ARG B 872
REMARK 465 ALA B 873
REMARK 465 LYS B 874
REMARK 465 LEU B 875
REMARK 465 LYS B 876
REMARK 465 ARG B 877
REMARK 465 ARG B 878
REMARK 465 GLU B 879
REMARK 465 VAL B 880
REMARK 465 LEU B 881
REMARK 465 GLY B 882
REMARK 465 ARG B 883
REMARK 465 LEU B 884
REMARK 465 LEU B 885
REMARK 465 ASP B 886
REMARK 465 GLY B 887
REMARK 465 VAL B 888
REMARK 465 ALA B 889
REMARK 465 GLU B 890
REMARK 465 ASP B 891
REMARK 465 GLU B 892
REMARK 465 ARG B 893
REMARK 465 LEU B 894
REMARK 465 GLY B 895
REMARK 465 ARG B 896
REMARK 465 ASP B 897
REMARK 465 SER B 898
REMARK 465 GLU B 899
REMARK 465 ILE B 900
REMARK 465 HIS B 901
REMARK 465 ARG B 902
REMARK 465 GLU B 903
REMARK 465 GLN B 904
REMARK 465 MET B 905
REMARK 465 GLU B 906
REMARK 465 ARG B 907
REMARK 465 LEU B 908
REMARK 465 VAL B 909
REMARK 465 ARG B 910
REMARK 465 GLU B 911
REMARK 465 GLU B 912
REMARK 465 LEU B 913
REMARK 465 GLU B 914
REMARK 465 ARG B 915
REMARK 465 TRP B 916
REMARK 465 GLU B 917
REMARK 465 SER B 918
REMARK 465 ASP B 919
REMARK 465 ASP B 920
REMARK 465 ALA B 921
REMARK 465 ALA B 922
REMARK 465 SER B 923
REMARK 465 GLN B 924
REMARK 465 ILE B 925
REMARK 465 SER B 926
REMARK 465 HIS B 927
REMARK 465 GLY B 928
REMARK 465 LEU B 929
REMARK 465 GLY B 930
REMARK 465 THR B 931
REMARK 465 PRO B 932
REMARK 465 VAL B 933
REMARK 465 GLY B 934
REMARK 465 LEU B 935
REMARK 465 ASN B 936
REMARK 465 GLY B 937
REMARK 465 GLN B 938
REMARK 465 PRO B 939
REMARK 465 ARG B 940
REMARK 465 PRO B 941
REMARK 465 ARG B 942
REMARK 465 SER B 943
REMARK 465 SER B 944
REMARK 465 ARG B 945
REMARK 465 PRO B 946
REMARK 465 SER B 947
REMARK 465 SER B 948
REMARK 465 SER B 949
REMARK 465 GLN B 950
REMARK 465 SER B 951
REMARK 465 THR B 952
REMARK 465 GLU B 953
REMARK 465 GLY B 954
REMARK 465 MET B 955
REMARK 465 GLU B 956
REMARK 465 GLY B 957
REMARK 465 ALA B 958
REMARK 465 GLY B 959
REMARK 465 GLY B 960
REMARK 465 ASN B 961
REMARK 465 GLY B 962
REMARK 465 SER B 963
REMARK 465 SER B 964
REMARK 465 ASN B 965
REMARK 465 VAL B 966
REMARK 465 HIS B 967
REMARK 465 VAL B 968
REMARK 465 MET C 1
REMARK 465 VAL C 2
REMARK 465 ASN C 3
REMARK 465 SER C 4
REMARK 465 SER C 5
REMARK 465 ARG C 6
REMARK 465 VAL C 7
REMARK 465 GLN C 8
REMARK 465 PRO C 9
REMARK 465 GLN C 10
REMARK 465 GLN C 11
REMARK 465 PRO C 12
REMARK 465 GLY C 13
REMARK 465 ASP C 14
REMARK 465 ALA C 15
REMARK 465 LYS C 16
REMARK 465 ARG C 17
REMARK 465 PRO C 18
REMARK 465 PRO C 19
REMARK 465 ALA C 20
REMARK 465 PRO C 21
REMARK 465 ARG C 22
REMARK 465 ALA C 23
REMARK 465 PRO C 24
REMARK 465 ASP C 25
REMARK 465 PRO C 26
REMARK 465 GLY C 27
REMARK 465 ARG C 28
REMARK 465 LEU C 29
REMARK 465 MET C 30
REMARK 465 ALA C 31
REMARK 465 GLY C 32
REMARK 465 CYS C 33
REMARK 465 ALA C 34
REMARK 465 ALA C 35
REMARK 465 VAL C 36
REMARK 465 GLY C 37
REMARK 465 ALA C 38
REMARK 465 SER C 39
REMARK 465 LEU C 40
REMARK 465 ALA C 41
REMARK 465 ALA C 42
REMARK 465 PRO C 43
REMARK 465 GLY C 44
REMARK 465 GLY C 45
REMARK 465 LEU C 46
REMARK 465 CYS C 47
REMARK 465 GLU C 48
REMARK 465 GLN C 49
REMARK 465 ARG C 50
REMARK 465 GLY C 51
REMARK 465 LEU C 52
REMARK 465 GLU C 53
REMARK 465 ILE C 54
REMARK 465 GLU C 55
REMARK 465 MET C 56
REMARK 465 GLN C 57
REMARK 465 ARG C 58
REMARK 465 ILE C 59
REMARK 465 ARG C 60
REMARK 465 GLN C 61
REMARK 465 ALA C 62
REMARK 465 ALA C 63
REMARK 465 ALA C 64
REMARK 465 ARG C 65
REMARK 465 ASP C 66
REMARK 465 PRO C 67
REMARK 465 PRO C 68
REMARK 465 ALA C 69
REMARK 465 GLY C 70
REMARK 465 ALA C 71
REMARK 465 ALA C 72
REMARK 465 ALA C 73
REMARK 465 SER C 74
REMARK 465 PRO C 75
REMARK 465 SER C 76
REMARK 465 PRO C 77
REMARK 465 PRO C 78
REMARK 465 LEU C 79
REMARK 465 SER C 80
REMARK 465 SER C 81
REMARK 465 CYS C 82
REMARK 465 SER C 83
REMARK 465 ARG C 84
REMARK 465 GLN C 85
REMARK 465 ALA C 86
REMARK 465 TRP C 87
REMARK 465 SER C 88
REMARK 465 ARG C 89
REMARK 465 ASP C 90
REMARK 465 ASN C 91
REMARK 465 PRO C 92
REMARK 465 GLY C 93
REMARK 465 PHE C 94
REMARK 465 GLU C 95
REMARK 465 ALA C 96
REMARK 465 GLU C 97
REMARK 465 GLU C 98
REMARK 465 GLU C 99
REMARK 465 GLU C 100
REMARK 465 GLU C 101
REMARK 465 GLU C 102
REMARK 465 VAL C 103
REMARK 465 GLU C 104
REMARK 465 GLY C 105
REMARK 465 GLU C 106
REMARK 465 GLU C 107
REMARK 465 GLY C 108
REMARK 465 GLY C 109
REMARK 465 MET C 110
REMARK 465 VAL C 111
REMARK 465 VAL C 112
REMARK 465 GLU C 113
REMARK 465 MET C 114
REMARK 465 ASP C 115
REMARK 465 VAL C 116
REMARK 465 GLU C 117
REMARK 465 TRP C 118
REMARK 465 ARG C 119
REMARK 465 PRO C 120
REMARK 465 GLY C 121
REMARK 465 SER C 122
REMARK 465 ARG C 123
REMARK 465 ARG C 124
REMARK 465 SER C 125
REMARK 465 ALA C 126
REMARK 465 ALA C 127
REMARK 465 SER C 128
REMARK 465 SER C 129
REMARK 465 ALA C 130
REMARK 465 VAL C 131
REMARK 465 SER C 132
REMARK 465 SER C 133
REMARK 465 VAL C 134
REMARK 465 GLY C 135
REMARK 465 ALA C 136
REMARK 465 ARG C 137
REMARK 465 SER C 138
REMARK 465 ARG C 139
REMARK 465 GLY C 140
REMARK 465 LEU C 141
REMARK 465 GLY C 142
REMARK 465 GLY C 143
REMARK 465 TYR C 144
REMARK 465 HIS C 145
REMARK 465 GLY C 146
REMARK 465 ALA C 147
REMARK 465 GLY C 148
REMARK 465 HIS C 149
REMARK 465 PRO C 150
REMARK 465 SER C 151
REMARK 465 GLY C 152
REMARK 465 ARG C 153
REMARK 465 ARG C 154
REMARK 465 ARG C 155
REMARK 465 ARG C 156
REMARK 465 ARG C 157
REMARK 465 GLU C 158
REMARK 465 ASP C 159
REMARK 465 GLN C 160
REMARK 465 GLY C 161
REMARK 465 PRO C 162
REMARK 465 PRO C 163
REMARK 465 CYS C 164
REMARK 465 PRO C 165
REMARK 465 SER C 166
REMARK 465 PRO C 167
REMARK 465 VAL C 168
REMARK 465 GLY C 169
REMARK 465 GLY C 170
REMARK 465 GLY C 171
REMARK 465 ASP C 172
REMARK 465 PRO C 173
REMARK 465 LEU C 174
REMARK 465 HIS C 175
REMARK 465 ARG C 176
REMARK 465 HIS C 177
REMARK 465 LEU C 178
REMARK 465 PRO C 179
REMARK 465 LEU C 180
REMARK 465 GLU C 181
REMARK 465 GLY C 182
REMARK 465 GLN C 183
REMARK 465 PRO C 184
REMARK 465 PRO C 185
REMARK 465 ARG C 186
REMARK 465 VAL C 187
REMARK 465 ALA C 188
REMARK 465 TRP C 189
REMARK 465 ALA C 190
REMARK 465 GLU C 191
REMARK 465 ARG C 192
REMARK 465 LEU C 193
REMARK 465 VAL C 194
REMARK 465 ARG C 195
REMARK 465 GLY C 196
REMARK 465 LEU C 197
REMARK 465 ARG C 198
REMARK 465 GLY C 199
REMARK 465 LEU C 200
REMARK 465 TRP C 201
REMARK 465 GLY C 202
REMARK 465 THR C 203
REMARK 465 ARG C 204
REMARK 465 LEU C 205
REMARK 465 MET C 206
REMARK 465 GLU C 207
REMARK 465 GLU C 208
REMARK 465 SER C 209
REMARK 465 SER C 210
REMARK 465 THR C 211
REMARK 465 ASN C 212
REMARK 465 ARG C 213
REMARK 465 GLU C 214
REMARK 465 SER C 298
REMARK 465 ASN C 299
REMARK 465 GLN C 300
REMARK 465 THR C 301
REMARK 465 GLU C 302
REMARK 465 ALA C 303
REMARK 465 ALA C 696
REMARK 465 GLU C 697
REMARK 465 MET C 698
REMARK 465 GLU C 699
REMARK 465 LEU C 700
REMARK 465 SER C 701
REMARK 465 ASP C 702
REMARK 465 LEU C 703
REMARK 465 ILE C 704
REMARK 465 ARG C 705
REMARK 465 LYS C 706
REMARK 465 GLY C 707
REMARK 465 TYR C 708
REMARK 465 HIS C 709
REMARK 465 LYS C 710
REMARK 465 ALA C 711
REMARK 465 LEU C 712
REMARK 465 VAL C 713
REMARK 465 LYS C 714
REMARK 465 LEU C 715
REMARK 465 LYS C 716
REMARK 465 LEU C 717
REMARK 465 LYS C 718
REMARK 465 LYS C 719
REMARK 465 ASN C 720
REMARK 465 THR C 721
REMARK 465 VAL C 722
REMARK 465 ASP C 723
REMARK 465 ASP C 724
REMARK 465 ILE C 725
REMARK 465 SER C 726
REMARK 465 GLU C 727
REMARK 465 SER C 728
REMARK 465 LEU C 729
REMARK 465 ARG C 730
REMARK 465 GLN C 731
REMARK 465 GLY C 732
REMARK 465 GLY C 733
REMARK 465 GLY C 734
REMARK 465 LYS C 735
REMARK 465 LEU C 736
REMARK 465 ASN C 737
REMARK 465 PHE C 738
REMARK 465 ASP C 739
REMARK 465 GLU C 740
REMARK 465 LEU C 741
REMARK 465 ARG C 742
REMARK 465 GLN C 743
REMARK 465 ASP C 744
REMARK 465 LEU C 745
REMARK 465 LYS C 746
REMARK 465 GLY C 747
REMARK 465 LYS C 748
REMARK 465 GLY C 749
REMARK 465 HIS C 750
REMARK 465 THR C 751
REMARK 465 ASP C 752
REMARK 465 ALA C 753
REMARK 465 GLU C 754
REMARK 465 ILE C 755
REMARK 465 GLU C 756
REMARK 465 ALA C 757
REMARK 465 ILE C 758
REMARK 465 PHE C 759
REMARK 465 THR C 760
REMARK 465 LYS C 761
REMARK 465 TYR C 762
REMARK 465 ASP C 763
REMARK 465 GLN C 764
REMARK 465 ASP C 765
REMARK 465 GLY C 766
REMARK 465 ASP C 767
REMARK 465 GLN C 768
REMARK 465 GLU C 769
REMARK 465 LEU C 770
REMARK 465 THR C 771
REMARK 465 GLU C 772
REMARK 465 HIS C 773
REMARK 465 GLU C 774
REMARK 465 HIS C 775
REMARK 465 GLN C 776
REMARK 465 GLN C 777
REMARK 465 MET C 778
REMARK 465 ARG C 779
REMARK 465 ASP C 780
REMARK 465 ASP C 781
REMARK 465 LEU C 782
REMARK 465 GLU C 783
REMARK 465 LYS C 784
REMARK 465 GLU C 785
REMARK 465 ARG C 786
REMARK 465 GLU C 787
REMARK 465 ASP C 788
REMARK 465 LEU C 789
REMARK 465 ASP C 790
REMARK 465 LEU C 791
REMARK 465 ASP C 792
REMARK 465 HIS C 793
REMARK 465 SER C 794
REMARK 465 SER C 795
REMARK 465 LEU C 796
REMARK 465 PRO C 797
REMARK 465 ARG C 798
REMARK 465 PRO C 799
REMARK 465 MET C 800
REMARK 465 SER C 801
REMARK 465 SER C 802
REMARK 465 ARG C 803
REMARK 465 SER C 804
REMARK 465 PHE C 805
REMARK 465 PRO C 806
REMARK 465 ARG C 807
REMARK 465 SER C 808
REMARK 465 LEU C 809
REMARK 465 ASP C 810
REMARK 465 ASP C 811
REMARK 465 SER C 812
REMARK 465 GLU C 813
REMARK 465 GLU C 814
REMARK 465 ASP C 815
REMARK 465 ASP C 816
REMARK 465 ASP C 817
REMARK 465 GLU C 818
REMARK 465 ASP C 819
REMARK 465 SER C 820
REMARK 465 GLY C 821
REMARK 465 HIS C 822
REMARK 465 SER C 823
REMARK 465 SER C 824
REMARK 465 ARG C 825
REMARK 465 ARG C 826
REMARK 465 ARG C 827
REMARK 465 GLY C 828
REMARK 465 SER C 829
REMARK 465 ILE C 830
REMARK 465 SER C 831
REMARK 465 SER C 832
REMARK 465 GLY C 833
REMARK 465 VAL C 834
REMARK 465 SER C 835
REMARK 465 TYR C 836
REMARK 465 GLU C 837
REMARK 465 GLU C 838
REMARK 465 PHE C 839
REMARK 465 GLN C 840
REMARK 465 VAL C 841
REMARK 465 LEU C 842
REMARK 465 VAL C 843
REMARK 465 ARG C 844
REMARK 465 ARG C 845
REMARK 465 VAL C 846
REMARK 465 ASP C 847
REMARK 465 ARG C 848
REMARK 465 MET C 849
REMARK 465 GLU C 850
REMARK 465 HIS C 851
REMARK 465 SER C 852
REMARK 465 ILE C 853
REMARK 465 GLY C 854
REMARK 465 SER C 855
REMARK 465 ILE C 856
REMARK 465 VAL C 857
REMARK 465 SER C 858
REMARK 465 LYS C 859
REMARK 465 ILE C 860
REMARK 465 ASP C 861
REMARK 465 ALA C 862
REMARK 465 VAL C 863
REMARK 465 ILE C 864
REMARK 465 VAL C 865
REMARK 465 LYS C 866
REMARK 465 LEU C 867
REMARK 465 GLU C 868
REMARK 465 ILE C 869
REMARK 465 MET C 870
REMARK 465 GLU C 871
REMARK 465 ARG C 872
REMARK 465 ALA C 873
REMARK 465 LYS C 874
REMARK 465 LEU C 875
REMARK 465 LYS C 876
REMARK 465 ARG C 877
REMARK 465 ARG C 878
REMARK 465 GLU C 879
REMARK 465 VAL C 880
REMARK 465 LEU C 881
REMARK 465 GLY C 882
REMARK 465 ARG C 883
REMARK 465 LEU C 884
REMARK 465 LEU C 885
REMARK 465 ASP C 886
REMARK 465 GLY C 887
REMARK 465 VAL C 888
REMARK 465 ALA C 889
REMARK 465 GLU C 890
REMARK 465 ASP C 891
REMARK 465 GLU C 892
REMARK 465 ARG C 893
REMARK 465 LEU C 894
REMARK 465 GLY C 895
REMARK 465 ARG C 896
REMARK 465 ASP C 897
REMARK 465 SER C 898
REMARK 465 GLU C 899
REMARK 465 ILE C 900
REMARK 465 HIS C 901
REMARK 465 ARG C 902
REMARK 465 GLU C 903
REMARK 465 GLN C 904
REMARK 465 MET C 905
REMARK 465 GLU C 906
REMARK 465 ARG C 907
REMARK 465 LEU C 908
REMARK 465 VAL C 909
REMARK 465 ARG C 910
REMARK 465 GLU C 911
REMARK 465 GLU C 912
REMARK 465 LEU C 913
REMARK 465 GLU C 914
REMARK 465 ARG C 915
REMARK 465 TRP C 916
REMARK 465 GLU C 917
REMARK 465 SER C 918
REMARK 465 ASP C 919
REMARK 465 ASP C 920
REMARK 465 ALA C 921
REMARK 465 ALA C 922
REMARK 465 SER C 923
REMARK 465 GLN C 924
REMARK 465 ILE C 925
REMARK 465 SER C 926
REMARK 465 HIS C 927
REMARK 465 GLY C 928
REMARK 465 LEU C 929
REMARK 465 GLY C 930
REMARK 465 THR C 931
REMARK 465 PRO C 932
REMARK 465 VAL C 933
REMARK 465 GLY C 934
REMARK 465 LEU C 935
REMARK 465 ASN C 936
REMARK 465 GLY C 937
REMARK 465 GLN C 938
REMARK 465 PRO C 939
REMARK 465 ARG C 940
REMARK 465 PRO C 941
REMARK 465 ARG C 942
REMARK 465 SER C 943
REMARK 465 SER C 944
REMARK 465 ARG C 945
REMARK 465 PRO C 946
REMARK 465 SER C 947
REMARK 465 SER C 948
REMARK 465 SER C 949
REMARK 465 GLN C 950
REMARK 465 SER C 951
REMARK 465 THR C 952
REMARK 465 GLU C 953
REMARK 465 GLY C 954
REMARK 465 MET C 955
REMARK 465 GLU C 956
REMARK 465 GLY C 957
REMARK 465 ALA C 958
REMARK 465 GLY C 959
REMARK 465 GLY C 960
REMARK 465 ASN C 961
REMARK 465 GLY C 962
REMARK 465 SER C 963
REMARK 465 SER C 964
REMARK 465 ASN C 965
REMARK 465 VAL C 966
REMARK 465 HIS C 967
REMARK 465 VAL C 968
REMARK 465 MET D 1
REMARK 465 VAL D 2
REMARK 465 ASN D 3
REMARK 465 SER D 4
REMARK 465 SER D 5
REMARK 465 ARG D 6
REMARK 465 VAL D 7
REMARK 465 GLN D 8
REMARK 465 PRO D 9
REMARK 465 GLN D 10
REMARK 465 GLN D 11
REMARK 465 PRO D 12
REMARK 465 GLY D 13
REMARK 465 ASP D 14
REMARK 465 ALA D 15
REMARK 465 LYS D 16
REMARK 465 ARG D 17
REMARK 465 PRO D 18
REMARK 465 PRO D 19
REMARK 465 ALA D 20
REMARK 465 PRO D 21
REMARK 465 ARG D 22
REMARK 465 ALA D 23
REMARK 465 PRO D 24
REMARK 465 ASP D 25
REMARK 465 PRO D 26
REMARK 465 GLY D 27
REMARK 465 ARG D 28
REMARK 465 LEU D 29
REMARK 465 MET D 30
REMARK 465 ALA D 31
REMARK 465 GLY D 32
REMARK 465 CYS D 33
REMARK 465 ALA D 34
REMARK 465 ALA D 35
REMARK 465 VAL D 36
REMARK 465 GLY D 37
REMARK 465 ALA D 38
REMARK 465 SER D 39
REMARK 465 LEU D 40
REMARK 465 ALA D 41
REMARK 465 ALA D 42
REMARK 465 PRO D 43
REMARK 465 GLY D 44
REMARK 465 GLY D 45
REMARK 465 LEU D 46
REMARK 465 CYS D 47
REMARK 465 GLU D 48
REMARK 465 GLN D 49
REMARK 465 ARG D 50
REMARK 465 GLY D 51
REMARK 465 LEU D 52
REMARK 465 GLU D 53
REMARK 465 ILE D 54
REMARK 465 GLU D 55
REMARK 465 MET D 56
REMARK 465 GLN D 57
REMARK 465 ARG D 58
REMARK 465 ILE D 59
REMARK 465 ARG D 60
REMARK 465 GLN D 61
REMARK 465 ALA D 62
REMARK 465 ALA D 63
REMARK 465 ALA D 64
REMARK 465 ARG D 65
REMARK 465 ASP D 66
REMARK 465 PRO D 67
REMARK 465 PRO D 68
REMARK 465 ALA D 69
REMARK 465 GLY D 70
REMARK 465 ALA D 71
REMARK 465 ALA D 72
REMARK 465 ALA D 73
REMARK 465 SER D 74
REMARK 465 PRO D 75
REMARK 465 SER D 76
REMARK 465 PRO D 77
REMARK 465 PRO D 78
REMARK 465 LEU D 79
REMARK 465 SER D 80
REMARK 465 SER D 81
REMARK 465 CYS D 82
REMARK 465 SER D 83
REMARK 465 ARG D 84
REMARK 465 GLN D 85
REMARK 465 ALA D 86
REMARK 465 TRP D 87
REMARK 465 SER D 88
REMARK 465 ARG D 89
REMARK 465 ASP D 90
REMARK 465 ASN D 91
REMARK 465 PRO D 92
REMARK 465 GLY D 93
REMARK 465 PHE D 94
REMARK 465 GLU D 95
REMARK 465 ALA D 96
REMARK 465 GLU D 97
REMARK 465 GLU D 98
REMARK 465 GLU D 99
REMARK 465 GLU D 100
REMARK 465 GLU D 101
REMARK 465 GLU D 102
REMARK 465 VAL D 103
REMARK 465 GLU D 104
REMARK 465 GLY D 105
REMARK 465 GLU D 106
REMARK 465 GLU D 107
REMARK 465 GLY D 108
REMARK 465 GLY D 109
REMARK 465 MET D 110
REMARK 465 VAL D 111
REMARK 465 VAL D 112
REMARK 465 GLU D 113
REMARK 465 MET D 114
REMARK 465 ASP D 115
REMARK 465 VAL D 116
REMARK 465 GLU D 117
REMARK 465 TRP D 118
REMARK 465 ARG D 119
REMARK 465 PRO D 120
REMARK 465 GLY D 121
REMARK 465 SER D 122
REMARK 465 ARG D 123
REMARK 465 ARG D 124
REMARK 465 SER D 125
REMARK 465 ALA D 126
REMARK 465 ALA D 127
REMARK 465 SER D 128
REMARK 465 SER D 129
REMARK 465 ALA D 130
REMARK 465 VAL D 131
REMARK 465 SER D 132
REMARK 465 SER D 133
REMARK 465 VAL D 134
REMARK 465 GLY D 135
REMARK 465 ALA D 136
REMARK 465 ARG D 137
REMARK 465 SER D 138
REMARK 465 ARG D 139
REMARK 465 GLY D 140
REMARK 465 LEU D 141
REMARK 465 GLY D 142
REMARK 465 GLY D 143
REMARK 465 TYR D 144
REMARK 465 HIS D 145
REMARK 465 GLY D 146
REMARK 465 ALA D 147
REMARK 465 GLY D 148
REMARK 465 HIS D 149
REMARK 465 PRO D 150
REMARK 465 SER D 151
REMARK 465 GLY D 152
REMARK 465 ARG D 153
REMARK 465 ARG D 154
REMARK 465 ARG D 155
REMARK 465 ARG D 156
REMARK 465 ARG D 157
REMARK 465 GLU D 158
REMARK 465 ASP D 159
REMARK 465 GLN D 160
REMARK 465 GLY D 161
REMARK 465 PRO D 162
REMARK 465 PRO D 163
REMARK 465 CYS D 164
REMARK 465 PRO D 165
REMARK 465 SER D 166
REMARK 465 PRO D 167
REMARK 465 VAL D 168
REMARK 465 GLY D 169
REMARK 465 GLY D 170
REMARK 465 GLY D 171
REMARK 465 ASP D 172
REMARK 465 PRO D 173
REMARK 465 LEU D 174
REMARK 465 HIS D 175
REMARK 465 ARG D 176
REMARK 465 HIS D 177
REMARK 465 LEU D 178
REMARK 465 PRO D 179
REMARK 465 LEU D 180
REMARK 465 GLU D 181
REMARK 465 GLY D 182
REMARK 465 GLN D 183
REMARK 465 PRO D 184
REMARK 465 PRO D 185
REMARK 465 ARG D 186
REMARK 465 VAL D 187
REMARK 465 ALA D 188
REMARK 465 TRP D 189
REMARK 465 ALA D 190
REMARK 465 GLU D 191
REMARK 465 ARG D 192
REMARK 465 LEU D 193
REMARK 465 VAL D 194
REMARK 465 ARG D 195
REMARK 465 GLY D 196
REMARK 465 LEU D 197
REMARK 465 ARG D 198
REMARK 465 GLY D 199
REMARK 465 LEU D 200
REMARK 465 TRP D 201
REMARK 465 GLY D 202
REMARK 465 THR D 203
REMARK 465 ARG D 204
REMARK 465 LEU D 205
REMARK 465 MET D 206
REMARK 465 GLU D 207
REMARK 465 GLU D 208
REMARK 465 SER D 209
REMARK 465 SER D 210
REMARK 465 THR D 211
REMARK 465 ASN D 212
REMARK 465 ARG D 213
REMARK 465 GLU D 214
REMARK 465 SER D 298
REMARK 465 ASN D 299
REMARK 465 GLN D 300
REMARK 465 THR D 301
REMARK 465 GLU D 302
REMARK 465 ALA D 303
REMARK 465 ALA D 696
REMARK 465 GLU D 697
REMARK 465 MET D 698
REMARK 465 GLU D 699
REMARK 465 LEU D 700
REMARK 465 SER D 701
REMARK 465 ASP D 702
REMARK 465 LEU D 703
REMARK 465 ILE D 704
REMARK 465 ARG D 705
REMARK 465 LYS D 706
REMARK 465 GLY D 707
REMARK 465 TYR D 708
REMARK 465 HIS D 709
REMARK 465 LYS D 710
REMARK 465 ALA D 711
REMARK 465 LEU D 712
REMARK 465 VAL D 713
REMARK 465 LYS D 714
REMARK 465 LEU D 715
REMARK 465 LYS D 716
REMARK 465 LEU D 717
REMARK 465 LYS D 718
REMARK 465 LYS D 719
REMARK 465 ASN D 720
REMARK 465 THR D 721
REMARK 465 VAL D 722
REMARK 465 ASP D 723
REMARK 465 ASP D 724
REMARK 465 ILE D 725
REMARK 465 SER D 726
REMARK 465 GLU D 727
REMARK 465 SER D 728
REMARK 465 LEU D 729
REMARK 465 ARG D 730
REMARK 465 GLN D 731
REMARK 465 GLY D 732
REMARK 465 GLY D 733
REMARK 465 GLY D 734
REMARK 465 LYS D 735
REMARK 465 LEU D 736
REMARK 465 ASN D 737
REMARK 465 PHE D 738
REMARK 465 ASP D 739
REMARK 465 GLU D 740
REMARK 465 LEU D 741
REMARK 465 ARG D 742
REMARK 465 GLN D 743
REMARK 465 ASP D 744
REMARK 465 LEU D 745
REMARK 465 LYS D 746
REMARK 465 GLY D 747
REMARK 465 LYS D 748
REMARK 465 GLY D 749
REMARK 465 HIS D 750
REMARK 465 THR D 751
REMARK 465 ASP D 752
REMARK 465 ALA D 753
REMARK 465 GLU D 754
REMARK 465 ILE D 755
REMARK 465 GLU D 756
REMARK 465 ALA D 757
REMARK 465 ILE D 758
REMARK 465 PHE D 759
REMARK 465 THR D 760
REMARK 465 LYS D 761
REMARK 465 TYR D 762
REMARK 465 ASP D 763
REMARK 465 GLN D 764
REMARK 465 ASP D 765
REMARK 465 GLY D 766
REMARK 465 ASP D 767
REMARK 465 GLN D 768
REMARK 465 GLU D 769
REMARK 465 LEU D 770
REMARK 465 THR D 771
REMARK 465 GLU D 772
REMARK 465 HIS D 773
REMARK 465 GLU D 774
REMARK 465 HIS D 775
REMARK 465 GLN D 776
REMARK 465 GLN D 777
REMARK 465 MET D 778
REMARK 465 ARG D 779
REMARK 465 ASP D 780
REMARK 465 ASP D 781
REMARK 465 LEU D 782
REMARK 465 GLU D 783
REMARK 465 LYS D 784
REMARK 465 GLU D 785
REMARK 465 ARG D 786
REMARK 465 GLU D 787
REMARK 465 ASP D 788
REMARK 465 LEU D 789
REMARK 465 ASP D 790
REMARK 465 LEU D 791
REMARK 465 ASP D 792
REMARK 465 HIS D 793
REMARK 465 SER D 794
REMARK 465 SER D 795
REMARK 465 LEU D 796
REMARK 465 PRO D 797
REMARK 465 ARG D 798
REMARK 465 PRO D 799
REMARK 465 MET D 800
REMARK 465 SER D 801
REMARK 465 SER D 802
REMARK 465 ARG D 803
REMARK 465 SER D 804
REMARK 465 PHE D 805
REMARK 465 PRO D 806
REMARK 465 ARG D 807
REMARK 465 SER D 808
REMARK 465 LEU D 809
REMARK 465 ASP D 810
REMARK 465 ASP D 811
REMARK 465 SER D 812
REMARK 465 GLU D 813
REMARK 465 GLU D 814
REMARK 465 ASP D 815
REMARK 465 ASP D 816
REMARK 465 ASP D 817
REMARK 465 GLU D 818
REMARK 465 ASP D 819
REMARK 465 SER D 820
REMARK 465 GLY D 821
REMARK 465 HIS D 822
REMARK 465 SER D 823
REMARK 465 SER D 824
REMARK 465 ARG D 825
REMARK 465 ARG D 826
REMARK 465 ARG D 827
REMARK 465 GLY D 828
REMARK 465 SER D 829
REMARK 465 ILE D 830
REMARK 465 SER D 831
REMARK 465 SER D 832
REMARK 465 GLY D 833
REMARK 465 VAL D 834
REMARK 465 SER D 835
REMARK 465 TYR D 836
REMARK 465 GLU D 837
REMARK 465 GLU D 838
REMARK 465 PHE D 839
REMARK 465 GLN D 840
REMARK 465 VAL D 841
REMARK 465 LEU D 842
REMARK 465 VAL D 843
REMARK 465 ARG D 844
REMARK 465 ARG D 845
REMARK 465 VAL D 846
REMARK 465 ASP D 847
REMARK 465 ARG D 848
REMARK 465 MET D 849
REMARK 465 GLU D 850
REMARK 465 HIS D 851
REMARK 465 SER D 852
REMARK 465 ILE D 853
REMARK 465 GLY D 854
REMARK 465 SER D 855
REMARK 465 ILE D 856
REMARK 465 VAL D 857
REMARK 465 SER D 858
REMARK 465 LYS D 859
REMARK 465 ILE D 860
REMARK 465 ASP D 861
REMARK 465 ALA D 862
REMARK 465 VAL D 863
REMARK 465 ILE D 864
REMARK 465 VAL D 865
REMARK 465 LYS D 866
REMARK 465 LEU D 867
REMARK 465 GLU D 868
REMARK 465 ILE D 869
REMARK 465 MET D 870
REMARK 465 GLU D 871
REMARK 465 ARG D 872
REMARK 465 ALA D 873
REMARK 465 LYS D 874
REMARK 465 LEU D 875
REMARK 465 LYS D 876
REMARK 465 ARG D 877
REMARK 465 ARG D 878
REMARK 465 GLU D 879
REMARK 465 VAL D 880
REMARK 465 LEU D 881
REMARK 465 GLY D 882
REMARK 465 ARG D 883
REMARK 465 LEU D 884
REMARK 465 LEU D 885
REMARK 465 ASP D 886
REMARK 465 GLY D 887
REMARK 465 VAL D 888
REMARK 465 ALA D 889
REMARK 465 GLU D 890
REMARK 465 ASP D 891
REMARK 465 GLU D 892
REMARK 465 ARG D 893
REMARK 465 LEU D 894
REMARK 465 GLY D 895
REMARK 465 ARG D 896
REMARK 465 ASP D 897
REMARK 465 SER D 898
REMARK 465 GLU D 899
REMARK 465 ILE D 900
REMARK 465 HIS D 901
REMARK 465 ARG D 902
REMARK 465 GLU D 903
REMARK 465 GLN D 904
REMARK 465 MET D 905
REMARK 465 GLU D 906
REMARK 465 ARG D 907
REMARK 465 LEU D 908
REMARK 465 VAL D 909
REMARK 465 ARG D 910
REMARK 465 GLU D 911
REMARK 465 GLU D 912
REMARK 465 LEU D 913
REMARK 465 GLU D 914
REMARK 465 ARG D 915
REMARK 465 TRP D 916
REMARK 465 GLU D 917
REMARK 465 SER D 918
REMARK 465 ASP D 919
REMARK 465 ASP D 920
REMARK 465 ALA D 921
REMARK 465 ALA D 922
REMARK 465 SER D 923
REMARK 465 GLN D 924
REMARK 465 ILE D 925
REMARK 465 SER D 926
REMARK 465 HIS D 927
REMARK 465 GLY D 928
REMARK 465 LEU D 929
REMARK 465 GLY D 930
REMARK 465 THR D 931
REMARK 465 PRO D 932
REMARK 465 VAL D 933
REMARK 465 GLY D 934
REMARK 465 LEU D 935
REMARK 465 ASN D 936
REMARK 465 GLY D 937
REMARK 465 GLN D 938
REMARK 465 PRO D 939
REMARK 465 ARG D 940
REMARK 465 PRO D 941
REMARK 465 ARG D 942
REMARK 465 SER D 943
REMARK 465 SER D 944
REMARK 465 ARG D 945
REMARK 465 PRO D 946
REMARK 465 SER D 947
REMARK 465 SER D 948
REMARK 465 SER D 949
REMARK 465 GLN D 950
REMARK 465 SER D 951
REMARK 465 THR D 952
REMARK 465 GLU D 953
REMARK 465 GLY D 954
REMARK 465 MET D 955
REMARK 465 GLU D 956
REMARK 465 GLY D 957
REMARK 465 ALA D 958
REMARK 465 GLY D 959
REMARK 465 GLY D 960
REMARK 465 ASN D 961
REMARK 465 GLY D 962
REMARK 465 SER D 963
REMARK 465 SER D 964
REMARK 465 ASN D 965
REMARK 465 VAL D 966
REMARK 465 HIS D 967
REMARK 465 VAL D 968
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 SER A 219 OG
REMARK 470 VAL A 623 O
REMARK 470 MET A 668 CG SD CE
REMARK 470 SER B 219 OG
REMARK 470 VAL B 623 O
REMARK 470 MET B 668 CG SD CE
REMARK 470 SER C 219 OG
REMARK 470 VAL C 623 O
REMARK 470 MET C 668 CG SD CE
REMARK 470 SER D 219 OG
REMARK 470 VAL D 623 O
REMARK 470 MET D 668 CG SD CE
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 O4 NAG D 1003 C1 NAG D 1004 1.55
REMARK 500 CD1 LEU B 573 CD1 ILE C 606 1.81
REMARK 500 CD1 LEU A 573 CD1 ILE B 606 1.83
REMARK 500 O PHE D 310 OE1 GLU D 312 1.85
REMARK 500 CD1 LEU C 573 CD1 ILE D 606 1.87
REMARK 500 CD1 ILE A 606 CD1 LEU D 573 1.91
REMARK 500 O ALA C 356 OH TYR C 391 2.04
REMARK 500 O ALA D 356 OH TYR D 391 2.04
REMARK 500 O ALA A 356 OH TYR A 391 2.04
REMARK 500 O ALA B 356 OH TYR B 391 2.04
REMARK 500 CG1 ILE B 309 O ASN B 313 2.07
REMARK 500 O GLU B 223 OG1 THR B 226 2.08
REMARK 500 O GLU C 223 OG1 THR C 226 2.08
REMARK 500 O GLU A 223 OG1 THR A 226 2.08
REMARK 500 O GLU D 223 OG1 THR D 226 2.08
REMARK 500 OG SER A 427 O CYS A 437 2.10
REMARK 500 OG SER C 427 O CYS C 437 2.10
REMARK 500 OG SER D 427 O CYS D 437 2.10
REMARK 500 OG SER B 427 O CYS B 437 2.10
REMARK 500 O ALA A 562 OG1 THR A 565 2.10
REMARK 500 O ALA D 562 OG1 THR D 565 2.10
REMARK 500 O ALA B 562 OG1 THR B 565 2.10
REMARK 500 O ALA C 562 OG1 THR C 565 2.11
REMARK 500 O ARG C 361 C8 NAG C 1002 2.11
REMARK 500 O ARG D 361 C8 NAG D 1002 2.11
REMARK 500 O ARG A 361 C8 NAG A 1002 2.11
REMARK 500 O ARG B 361 C8 NAG B 1002 2.11
REMARK 500 O PHE D 310 CD GLU D 312 2.11
REMARK 500 O TYR D 611 N ALA D 615 2.13
REMARK 500 O TYR A 611 N ALA A 615 2.13
REMARK 500 O TYR B 611 N ALA B 615 2.13
REMARK 500 O TYR C 611 N ALA C 615 2.13
REMARK 500 NE2 GLN A 323 OD1 ASP A 416 2.14
REMARK 500 NE2 GLN C 323 OD1 ASP C 416 2.14
REMARK 500 O TRP C 554 N PHE C 558 2.14
REMARK 500 O TRP A 554 N PHE A 558 2.14
REMARK 500 NE2 GLN D 323 OD1 ASP D 416 2.14
REMARK 500 NE2 GLN B 323 OD1 ASP B 416 2.14
REMARK 500 O TRP B 554 N PHE B 558 2.14
REMARK 500 O TRP D 554 N PHE D 558 2.14
REMARK 500 O PHE B 436 N LEU B 460 2.15
REMARK 500 O PHE C 436 N LEU C 460 2.15
REMARK 500 O PHE A 436 N LEU A 460 2.15
REMARK 500 O PHE D 436 N LEU D 460 2.15
REMARK 500 OG1 THR A 467 OE1 GLN B 335 2.15
REMARK 500 OD1 ASP C 425 N LEU C 441 2.15
REMARK 500 OD1 ASP D 425 N LEU D 441 2.15
REMARK 500 OD1 ASP B 425 N LEU B 441 2.15
REMARK 500 OD1 ASP A 425 N LEU A 441 2.15
REMARK 500 OD1 ASN A 269 N THR A 272 2.15
REMARK 500
REMARK 500 THIS ENTRY HAS 89 CLOSE CONTACTS
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 THR A 250 -72.05 -73.91
REMARK 500 SER A 254 -72.76 -88.69
REMARK 500 PHE A 257 -61.59 -121.62
REMARK 500 LEU A 258 -74.90 -52.97
REMARK 500 LYS A 267 -72.23 -50.53
REMARK 500 SER A 274 -69.27 -133.38
REMARK 500 THR A 283 -71.62 -57.33
REMARK 500 SER A 286 -82.09 -123.40
REMARK 500 ARG A 306 109.45 -160.78
REMARK 500 TYR A 311 -3.03 69.39
REMARK 500 GLU A 312 -76.37 -107.67
REMARK 500 VAL A 318 142.89 -175.72
REMARK 500 GLN A 323 -177.12 -172.74
REMARK 500 ARG A 325 160.50 178.71
REMARK 500 SER A 332 68.60 65.71
REMARK 500 SER A 352 -74.89 -60.75
REMARK 500 GLU A 353 60.59 33.11
REMARK 500 ASN A 375 -64.03 -99.96
REMARK 500 TRP A 380 -74.66 -81.74
REMARK 500 THR A 385 75.84 58.28
REMARK 500 GLU A 400 -74.09 -60.15
REMARK 500 TRP A 414 -155.16 51.85
REMARK 500 ARG A 417 -71.13 -132.92
REMARK 500 PHE A 426 -173.64 -170.97
REMARK 500 SER A 454 -167.52 -171.34
REMARK 500 THR A 468 -70.48 -119.00
REMARK 500 LYS A 499 -74.59 -105.33
REMARK 500 ARG A 504 -6.76 65.21
REMARK 500 PHE A 506 -6.13 65.86
REMARK 500 ASN A 508 -73.15 -93.55
REMARK 500 ASN A 525 -71.37 -57.41
REMARK 500 ASN A 531 -70.33 -57.93
REMARK 500 VAL A 534 -71.10 -57.62
REMARK 500 PHE A 538 -64.44 -96.65
REMARK 500 PHE A 567 -71.04 -50.93
REMARK 500 ALA A 610 -70.83 -51.00
REMARK 500 VAL A 623 155.55 178.27
REMARK 500 ASP A 625 -8.68 65.54
REMARK 500 ASP A 643 -3.40 65.23
REMARK 500 ALA A 652 -72.39 -55.65
REMARK 500 PHE A 666 -71.93 -63.44
REMARK 500 PHE A 667 -72.50 -57.93
REMARK 500 LEU A 673 -71.07 -56.61
REMARK 500 THR B 250 -72.04 -73.98
REMARK 500 SER B 254 -72.82 -88.63
REMARK 500 PHE B 257 -61.66 -121.61
REMARK 500 LEU B 258 -74.94 -52.93
REMARK 500 LYS B 267 -72.17 -50.56
REMARK 500 SER B 274 -69.31 -133.40
REMARK 500 THR B 283 -71.64 -57.31
REMARK 500
REMARK 500 THIS ENTRY HAS 175 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 LEU A 291 TYR A 292 -140.44
REMARK 500 ASP A 354 ARG A 355 -149.72
REMARK 500 ARG A 361 ASN A 362 148.28
REMARK 500 ASN A 578 PHE A 579 146.20
REMARK 500 SER A 627 THR A 628 137.09
REMARK 500 LEU B 291 TYR B 292 -140.52
REMARK 500 ASP B 354 ARG B 355 -149.72
REMARK 500 ARG B 361 ASN B 362 148.31
REMARK 500 ASN B 578 PHE B 579 146.25
REMARK 500 SER B 627 THR B 628 137.11
REMARK 500 LEU C 291 TYR C 292 -140.53
REMARK 500 ASP C 354 ARG C 355 -149.75
REMARK 500 ARG C 361 ASN C 362 148.28
REMARK 500 ASN C 578 PHE C 579 146.21
REMARK 500 SER C 627 THR C 628 137.07
REMARK 500 LEU D 291 TYR D 292 -140.47
REMARK 500 ASP D 354 ARG D 355 -149.68
REMARK 500 ARG D 361 ASN D 362 148.29
REMARK 500 ASN D 578 PHE D 579 146.23
REMARK 500 SER D 627 THR D 628 137.07
REMARK 500
REMARK 500 REMARK: NULL
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610 M RES C SSEQI
REMARK 610 PX6 A 1007
REMARK 610 PX6 B 1007
REMARK 610 PX6 C 1007
REMARK 610 NAG D 1004
REMARK 610 PX6 D 1007
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-3523 RELATED DB: EMDB
REMARK 900 CRYOEM STRUCTURE OF POLYCYSTIN-2 IN CATION WITH CALCIUM AND LIPIDS
DBREF 5MKE A 1 968 UNP Q13563 PKD2_HUMAN 1 968
DBREF 5MKE B 1 968 UNP Q13563 PKD2_HUMAN 1 968
DBREF 5MKE C 1 968 UNP Q13563 PKD2_HUMAN 1 968
DBREF 5MKE D 1 968 UNP Q13563 PKD2_HUMAN 1 968
SEQRES 1 A 968 MET VAL ASN SER SER ARG VAL GLN PRO GLN GLN PRO GLY
SEQRES 2 A 968 ASP ALA LYS ARG PRO PRO ALA PRO ARG ALA PRO ASP PRO
SEQRES 3 A 968 GLY ARG LEU MET ALA GLY CYS ALA ALA VAL GLY ALA SER
SEQRES 4 A 968 LEU ALA ALA PRO GLY GLY LEU CYS GLU GLN ARG GLY LEU
SEQRES 5 A 968 GLU ILE GLU MET GLN ARG ILE ARG GLN ALA ALA ALA ARG
SEQRES 6 A 968 ASP PRO PRO ALA GLY ALA ALA ALA SER PRO SER PRO PRO
SEQRES 7 A 968 LEU SER SER CYS SER ARG GLN ALA TRP SER ARG ASP ASN
SEQRES 8 A 968 PRO GLY PHE GLU ALA GLU GLU GLU GLU GLU GLU VAL GLU
SEQRES 9 A 968 GLY GLU GLU GLY GLY MET VAL VAL GLU MET ASP VAL GLU
SEQRES 10 A 968 TRP ARG PRO GLY SER ARG ARG SER ALA ALA SER SER ALA
SEQRES 11 A 968 VAL SER SER VAL GLY ALA ARG SER ARG GLY LEU GLY GLY
SEQRES 12 A 968 TYR HIS GLY ALA GLY HIS PRO SER GLY ARG ARG ARG ARG
SEQRES 13 A 968 ARG GLU ASP GLN GLY PRO PRO CYS PRO SER PRO VAL GLY
SEQRES 14 A 968 GLY GLY ASP PRO LEU HIS ARG HIS LEU PRO LEU GLU GLY
SEQRES 15 A 968 GLN PRO PRO ARG VAL ALA TRP ALA GLU ARG LEU VAL ARG
SEQRES 16 A 968 GLY LEU ARG GLY LEU TRP GLY THR ARG LEU MET GLU GLU
SEQRES 17 A 968 SER SER THR ASN ARG GLU LYS TYR LEU LYS SER VAL LEU
SEQRES 18 A 968 ARG GLU LEU VAL THR TYR LEU LEU PHE LEU ILE VAL LEU
SEQRES 19 A 968 CYS ILE LEU THR TYR GLY MET MET SER SER ASN VAL TYR
SEQRES 20 A 968 TYR TYR THR ARG MET MET SER GLN LEU PHE LEU ASP THR
SEQRES 21 A 968 PRO VAL SER LYS THR GLU LYS THR ASN PHE LYS THR LEU
SEQRES 22 A 968 SER SER MET GLU ASP PHE TRP LYS PHE THR GLU GLY SER
SEQRES 23 A 968 LEU LEU ASP GLY LEU TYR TRP LYS MET GLN PRO SER ASN
SEQRES 24 A 968 GLN THR GLU ALA ASP ASN ARG SER PHE ILE PHE TYR GLU
SEQRES 25 A 968 ASN LEU LEU LEU GLY VAL PRO ARG ILE ARG GLN LEU ARG
SEQRES 26 A 968 VAL ARG ASN GLY SER CYS SER ILE PRO GLN ASP LEU ARG
SEQRES 27 A 968 ASP GLU ILE LYS GLU CYS TYR ASP VAL TYR SER VAL SER
SEQRES 28 A 968 SER GLU ASP ARG ALA PRO PHE GLY PRO ARG ASN GLY THR
SEQRES 29 A 968 ALA TRP ILE TYR THR SER GLU LYS ASP LEU ASN GLY SER
SEQRES 30 A 968 SER HIS TRP GLY ILE ILE ALA THR TYR SER GLY ALA GLY
SEQRES 31 A 968 TYR TYR LEU ASP LEU SER ARG THR ARG GLU GLU THR ALA
SEQRES 32 A 968 ALA GLN VAL ALA SER LEU LYS LYS ASN VAL TRP LEU ASP
SEQRES 33 A 968 ARG GLY THR ARG ALA THR PHE ILE ASP PHE SER VAL TYR
SEQRES 34 A 968 ASN ALA ASN ILE ASN LEU PHE CYS VAL VAL ARG LEU LEU
SEQRES 35 A 968 VAL GLU PHE PRO ALA THR GLY GLY VAL ILE PRO SER TRP
SEQRES 36 A 968 GLN PHE GLN PRO LEU LYS LEU ILE ARG TYR VAL THR THR
SEQRES 37 A 968 PHE ASP PHE PHE LEU ALA ALA CYS GLU ILE ILE PHE CYS
SEQRES 38 A 968 PHE PHE ILE PHE TYR TYR VAL VAL GLU GLU ILE LEU GLU
SEQRES 39 A 968 ILE ARG ILE HIS LYS LEU HIS TYR PHE ARG SER PHE TRP
SEQRES 40 A 968 ASN CYS LEU ASP VAL VAL ILE VAL VAL LEU SER VAL VAL
SEQRES 41 A 968 ALA ILE GLY ILE ASN ILE TYR ARG THR SER ASN VAL GLU
SEQRES 42 A 968 VAL LEU LEU GLN PHE LEU GLU ASP GLN ASN THR PHE PRO
SEQRES 43 A 968 ASN PHE GLU HIS LEU ALA TYR TRP GLN ILE GLN PHE ASN
SEQRES 44 A 968 ASN ILE ALA ALA VAL THR VAL PHE PHE VAL TRP ILE LYS
SEQRES 45 A 968 LEU PHE LYS PHE ILE ASN PHE ASN ARG THR MET SER GLN
SEQRES 46 A 968 LEU SER THR THR MET SER ARG CYS ALA LYS ASP LEU PHE
SEQRES 47 A 968 GLY PHE ALA ILE MET PHE PHE ILE ILE PHE LEU ALA TYR
SEQRES 48 A 968 ALA GLN LEU ALA TYR LEU VAL PHE GLY THR GLN VAL ASP
SEQRES 49 A 968 ASP PHE SER THR PHE GLN GLU CYS ILE PHE THR GLN PHE
SEQRES 50 A 968 ARG ILE ILE LEU GLY ASP ILE ASN PHE ALA GLU ILE GLU
SEQRES 51 A 968 GLU ALA ASN ARG VAL LEU GLY PRO ILE TYR PHE THR THR
SEQRES 52 A 968 PHE VAL PHE PHE MET PHE PHE ILE LEU LEU ASN MET PHE
SEQRES 53 A 968 LEU ALA ILE ILE ASN ASP THR TYR SER GLU VAL LYS SER
SEQRES 54 A 968 ASP LEU ALA GLN GLN LYS ALA GLU MET GLU LEU SER ASP
SEQRES 55 A 968 LEU ILE ARG LYS GLY TYR HIS LYS ALA LEU VAL LYS LEU
SEQRES 56 A 968 LYS LEU LYS LYS ASN THR VAL ASP ASP ILE SER GLU SER
SEQRES 57 A 968 LEU ARG GLN GLY GLY GLY LYS LEU ASN PHE ASP GLU LEU
SEQRES 58 A 968 ARG GLN ASP LEU LYS GLY LYS GLY HIS THR ASP ALA GLU
SEQRES 59 A 968 ILE GLU ALA ILE PHE THR LYS TYR ASP GLN ASP GLY ASP
SEQRES 60 A 968 GLN GLU LEU THR GLU HIS GLU HIS GLN GLN MET ARG ASP
SEQRES 61 A 968 ASP LEU GLU LYS GLU ARG GLU ASP LEU ASP LEU ASP HIS
SEQRES 62 A 968 SER SER LEU PRO ARG PRO MET SER SER ARG SER PHE PRO
SEQRES 63 A 968 ARG SER LEU ASP ASP SER GLU GLU ASP ASP ASP GLU ASP
SEQRES 64 A 968 SER GLY HIS SER SER ARG ARG ARG GLY SER ILE SER SER
SEQRES 65 A 968 GLY VAL SER TYR GLU GLU PHE GLN VAL LEU VAL ARG ARG
SEQRES 66 A 968 VAL ASP ARG MET GLU HIS SER ILE GLY SER ILE VAL SER
SEQRES 67 A 968 LYS ILE ASP ALA VAL ILE VAL LYS LEU GLU ILE MET GLU
SEQRES 68 A 968 ARG ALA LYS LEU LYS ARG ARG GLU VAL LEU GLY ARG LEU
SEQRES 69 A 968 LEU ASP GLY VAL ALA GLU ASP GLU ARG LEU GLY ARG ASP
SEQRES 70 A 968 SER GLU ILE HIS ARG GLU GLN MET GLU ARG LEU VAL ARG
SEQRES 71 A 968 GLU GLU LEU GLU ARG TRP GLU SER ASP ASP ALA ALA SER
SEQRES 72 A 968 GLN ILE SER HIS GLY LEU GLY THR PRO VAL GLY LEU ASN
SEQRES 73 A 968 GLY GLN PRO ARG PRO ARG SER SER ARG PRO SER SER SER
SEQRES 74 A 968 GLN SER THR GLU GLY MET GLU GLY ALA GLY GLY ASN GLY
SEQRES 75 A 968 SER SER ASN VAL HIS VAL
SEQRES 1 B 968 MET VAL ASN SER SER ARG VAL GLN PRO GLN GLN PRO GLY
SEQRES 2 B 968 ASP ALA LYS ARG PRO PRO ALA PRO ARG ALA PRO ASP PRO
SEQRES 3 B 968 GLY ARG LEU MET ALA GLY CYS ALA ALA VAL GLY ALA SER
SEQRES 4 B 968 LEU ALA ALA PRO GLY GLY LEU CYS GLU GLN ARG GLY LEU
SEQRES 5 B 968 GLU ILE GLU MET GLN ARG ILE ARG GLN ALA ALA ALA ARG
SEQRES 6 B 968 ASP PRO PRO ALA GLY ALA ALA ALA SER PRO SER PRO PRO
SEQRES 7 B 968 LEU SER SER CYS SER ARG GLN ALA TRP SER ARG ASP ASN
SEQRES 8 B 968 PRO GLY PHE GLU ALA GLU GLU GLU GLU GLU GLU VAL GLU
SEQRES 9 B 968 GLY GLU GLU GLY GLY MET VAL VAL GLU MET ASP VAL GLU
SEQRES 10 B 968 TRP ARG PRO GLY SER ARG ARG SER ALA ALA SER SER ALA
SEQRES 11 B 968 VAL SER SER VAL GLY ALA ARG SER ARG GLY LEU GLY GLY
SEQRES 12 B 968 TYR HIS GLY ALA GLY HIS PRO SER GLY ARG ARG ARG ARG
SEQRES 13 B 968 ARG GLU ASP GLN GLY PRO PRO CYS PRO SER PRO VAL GLY
SEQRES 14 B 968 GLY GLY ASP PRO LEU HIS ARG HIS LEU PRO LEU GLU GLY
SEQRES 15 B 968 GLN PRO PRO ARG VAL ALA TRP ALA GLU ARG LEU VAL ARG
SEQRES 16 B 968 GLY LEU ARG GLY LEU TRP GLY THR ARG LEU MET GLU GLU
SEQRES 17 B 968 SER SER THR ASN ARG GLU LYS TYR LEU LYS SER VAL LEU
SEQRES 18 B 968 ARG GLU LEU VAL THR TYR LEU LEU PHE LEU ILE VAL LEU
SEQRES 19 B 968 CYS ILE LEU THR TYR GLY MET MET SER SER ASN VAL TYR
SEQRES 20 B 968 TYR TYR THR ARG MET MET SER GLN LEU PHE LEU ASP THR
SEQRES 21 B 968 PRO VAL SER LYS THR GLU LYS THR ASN PHE LYS THR LEU
SEQRES 22 B 968 SER SER MET GLU ASP PHE TRP LYS PHE THR GLU GLY SER
SEQRES 23 B 968 LEU LEU ASP GLY LEU TYR TRP LYS MET GLN PRO SER ASN
SEQRES 24 B 968 GLN THR GLU ALA ASP ASN ARG SER PHE ILE PHE TYR GLU
SEQRES 25 B 968 ASN LEU LEU LEU GLY VAL PRO ARG ILE ARG GLN LEU ARG
SEQRES 26 B 968 VAL ARG ASN GLY SER CYS SER ILE PRO GLN ASP LEU ARG
SEQRES 27 B 968 ASP GLU ILE LYS GLU CYS TYR ASP VAL TYR SER VAL SER
SEQRES 28 B 968 SER GLU ASP ARG ALA PRO PHE GLY PRO ARG ASN GLY THR
SEQRES 29 B 968 ALA TRP ILE TYR THR SER GLU LYS ASP LEU ASN GLY SER
SEQRES 30 B 968 SER HIS TRP GLY ILE ILE ALA THR TYR SER GLY ALA GLY
SEQRES 31 B 968 TYR TYR LEU ASP LEU SER ARG THR ARG GLU GLU THR ALA
SEQRES 32 B 968 ALA GLN VAL ALA SER LEU LYS LYS ASN VAL TRP LEU ASP
SEQRES 33 B 968 ARG GLY THR ARG ALA THR PHE ILE ASP PHE SER VAL TYR
SEQRES 34 B 968 ASN ALA ASN ILE ASN LEU PHE CYS VAL VAL ARG LEU LEU
SEQRES 35 B 968 VAL GLU PHE PRO ALA THR GLY GLY VAL ILE PRO SER TRP
SEQRES 36 B 968 GLN PHE GLN PRO LEU LYS LEU ILE ARG TYR VAL THR THR
SEQRES 37 B 968 PHE ASP PHE PHE LEU ALA ALA CYS GLU ILE ILE PHE CYS
SEQRES 38 B 968 PHE PHE ILE PHE TYR TYR VAL VAL GLU GLU ILE LEU GLU
SEQRES 39 B 968 ILE ARG ILE HIS LYS LEU HIS TYR PHE ARG SER PHE TRP
SEQRES 40 B 968 ASN CYS LEU ASP VAL VAL ILE VAL VAL LEU SER VAL VAL
SEQRES 41 B 968 ALA ILE GLY ILE ASN ILE TYR ARG THR SER ASN VAL GLU
SEQRES 42 B 968 VAL LEU LEU GLN PHE LEU GLU ASP GLN ASN THR PHE PRO
SEQRES 43 B 968 ASN PHE GLU HIS LEU ALA TYR TRP GLN ILE GLN PHE ASN
SEQRES 44 B 968 ASN ILE ALA ALA VAL THR VAL PHE PHE VAL TRP ILE LYS
SEQRES 45 B 968 LEU PHE LYS PHE ILE ASN PHE ASN ARG THR MET SER GLN
SEQRES 46 B 968 LEU SER THR THR MET SER ARG CYS ALA LYS ASP LEU PHE
SEQRES 47 B 968 GLY PHE ALA ILE MET PHE PHE ILE ILE PHE LEU ALA TYR
SEQRES 48 B 968 ALA GLN LEU ALA TYR LEU VAL PHE GLY THR GLN VAL ASP
SEQRES 49 B 968 ASP PHE SER THR PHE GLN GLU CYS ILE PHE THR GLN PHE
SEQRES 50 B 968 ARG ILE ILE LEU GLY ASP ILE ASN PHE ALA GLU ILE GLU
SEQRES 51 B 968 GLU ALA ASN ARG VAL LEU GLY PRO ILE TYR PHE THR THR
SEQRES 52 B 968 PHE VAL PHE PHE MET PHE PHE ILE LEU LEU ASN MET PHE
SEQRES 53 B 968 LEU ALA ILE ILE ASN ASP THR TYR SER GLU VAL LYS SER
SEQRES 54 B 968 ASP LEU ALA GLN GLN LYS ALA GLU MET GLU LEU SER ASP
SEQRES 55 B 968 LEU ILE ARG LYS GLY TYR HIS LYS ALA LEU VAL LYS LEU
SEQRES 56 B 968 LYS LEU LYS LYS ASN THR VAL ASP ASP ILE SER GLU SER
SEQRES 57 B 968 LEU ARG GLN GLY GLY GLY LYS LEU ASN PHE ASP GLU LEU
SEQRES 58 B 968 ARG GLN ASP LEU LYS GLY LYS GLY HIS THR ASP ALA GLU
SEQRES 59 B 968 ILE GLU ALA ILE PHE THR LYS TYR ASP GLN ASP GLY ASP
SEQRES 60 B 968 GLN GLU LEU THR GLU HIS GLU HIS GLN GLN MET ARG ASP
SEQRES 61 B 968 ASP LEU GLU LYS GLU ARG GLU ASP LEU ASP LEU ASP HIS
SEQRES 62 B 968 SER SER LEU PRO ARG PRO MET SER SER ARG SER PHE PRO
SEQRES 63 B 968 ARG SER LEU ASP ASP SER GLU GLU ASP ASP ASP GLU ASP
SEQRES 64 B 968 SER GLY HIS SER SER ARG ARG ARG GLY SER ILE SER SER
SEQRES 65 B 968 GLY VAL SER TYR GLU GLU PHE GLN VAL LEU VAL ARG ARG
SEQRES 66 B 968 VAL ASP ARG MET GLU HIS SER ILE GLY SER ILE VAL SER
SEQRES 67 B 968 LYS ILE ASP ALA VAL ILE VAL LYS LEU GLU ILE MET GLU
SEQRES 68 B 968 ARG ALA LYS LEU LYS ARG ARG GLU VAL LEU GLY ARG LEU
SEQRES 69 B 968 LEU ASP GLY VAL ALA GLU ASP GLU ARG LEU GLY ARG ASP
SEQRES 70 B 968 SER GLU ILE HIS ARG GLU GLN MET GLU ARG LEU VAL ARG
SEQRES 71 B 968 GLU GLU LEU GLU ARG TRP GLU SER ASP ASP ALA ALA SER
SEQRES 72 B 968 GLN ILE SER HIS GLY LEU GLY THR PRO VAL GLY LEU ASN
SEQRES 73 B 968 GLY GLN PRO ARG PRO ARG SER SER ARG PRO SER SER SER
SEQRES 74 B 968 GLN SER THR GLU GLY MET GLU GLY ALA GLY GLY ASN GLY
SEQRES 75 B 968 SER SER ASN VAL HIS VAL
SEQRES 1 C 968 MET VAL ASN SER SER ARG VAL GLN PRO GLN GLN PRO GLY
SEQRES 2 C 968 ASP ALA LYS ARG PRO PRO ALA PRO ARG ALA PRO ASP PRO
SEQRES 3 C 968 GLY ARG LEU MET ALA GLY CYS ALA ALA VAL GLY ALA SER
SEQRES 4 C 968 LEU ALA ALA PRO GLY GLY LEU CYS GLU GLN ARG GLY LEU
SEQRES 5 C 968 GLU ILE GLU MET GLN ARG ILE ARG GLN ALA ALA ALA ARG
SEQRES 6 C 968 ASP PRO PRO ALA GLY ALA ALA ALA SER PRO SER PRO PRO
SEQRES 7 C 968 LEU SER SER CYS SER ARG GLN ALA TRP SER ARG ASP ASN
SEQRES 8 C 968 PRO GLY PHE GLU ALA GLU GLU GLU GLU GLU GLU VAL GLU
SEQRES 9 C 968 GLY GLU GLU GLY GLY MET VAL VAL GLU MET ASP VAL GLU
SEQRES 10 C 968 TRP ARG PRO GLY SER ARG ARG SER ALA ALA SER SER ALA
SEQRES 11 C 968 VAL SER SER VAL GLY ALA ARG SER ARG GLY LEU GLY GLY
SEQRES 12 C 968 TYR HIS GLY ALA GLY HIS PRO SER GLY ARG ARG ARG ARG
SEQRES 13 C 968 ARG GLU ASP GLN GLY PRO PRO CYS PRO SER PRO VAL GLY
SEQRES 14 C 968 GLY GLY ASP PRO LEU HIS ARG HIS LEU PRO LEU GLU GLY
SEQRES 15 C 968 GLN PRO PRO ARG VAL ALA TRP ALA GLU ARG LEU VAL ARG
SEQRES 16 C 968 GLY LEU ARG GLY LEU TRP GLY THR ARG LEU MET GLU GLU
SEQRES 17 C 968 SER SER THR ASN ARG GLU LYS TYR LEU LYS SER VAL LEU
SEQRES 18 C 968 ARG GLU LEU VAL THR TYR LEU LEU PHE LEU ILE VAL LEU
SEQRES 19 C 968 CYS ILE LEU THR TYR GLY MET MET SER SER ASN VAL TYR
SEQRES 20 C 968 TYR TYR THR ARG MET MET SER GLN LEU PHE LEU ASP THR
SEQRES 21 C 968 PRO VAL SER LYS THR GLU LYS THR ASN PHE LYS THR LEU
SEQRES 22 C 968 SER SER MET GLU ASP PHE TRP LYS PHE THR GLU GLY SER
SEQRES 23 C 968 LEU LEU ASP GLY LEU TYR TRP LYS MET GLN PRO SER ASN
SEQRES 24 C 968 GLN THR GLU ALA ASP ASN ARG SER PHE ILE PHE TYR GLU
SEQRES 25 C 968 ASN LEU LEU LEU GLY VAL PRO ARG ILE ARG GLN LEU ARG
SEQRES 26 C 968 VAL ARG ASN GLY SER CYS SER ILE PRO GLN ASP LEU ARG
SEQRES 27 C 968 ASP GLU ILE LYS GLU CYS TYR ASP VAL TYR SER VAL SER
SEQRES 28 C 968 SER GLU ASP ARG ALA PRO PHE GLY PRO ARG ASN GLY THR
SEQRES 29 C 968 ALA TRP ILE TYR THR SER GLU LYS ASP LEU ASN GLY SER
SEQRES 30 C 968 SER HIS TRP GLY ILE ILE ALA THR TYR SER GLY ALA GLY
SEQRES 31 C 968 TYR TYR LEU ASP LEU SER ARG THR ARG GLU GLU THR ALA
SEQRES 32 C 968 ALA GLN VAL ALA SER LEU LYS LYS ASN VAL TRP LEU ASP
SEQRES 33 C 968 ARG GLY THR ARG ALA THR PHE ILE ASP PHE SER VAL TYR
SEQRES 34 C 968 ASN ALA ASN ILE ASN LEU PHE CYS VAL VAL ARG LEU LEU
SEQRES 35 C 968 VAL GLU PHE PRO ALA THR GLY GLY VAL ILE PRO SER TRP
SEQRES 36 C 968 GLN PHE GLN PRO LEU LYS LEU ILE ARG TYR VAL THR THR
SEQRES 37 C 968 PHE ASP PHE PHE LEU ALA ALA CYS GLU ILE ILE PHE CYS
SEQRES 38 C 968 PHE PHE ILE PHE TYR TYR VAL VAL GLU GLU ILE LEU GLU
SEQRES 39 C 968 ILE ARG ILE HIS LYS LEU HIS TYR PHE ARG SER PHE TRP
SEQRES 40 C 968 ASN CYS LEU ASP VAL VAL ILE VAL VAL LEU SER VAL VAL
SEQRES 41 C 968 ALA ILE GLY ILE ASN ILE TYR ARG THR SER ASN VAL GLU
SEQRES 42 C 968 VAL LEU LEU GLN PHE LEU GLU ASP GLN ASN THR PHE PRO
SEQRES 43 C 968 ASN PHE GLU HIS LEU ALA TYR TRP GLN ILE GLN PHE ASN
SEQRES 44 C 968 ASN ILE ALA ALA VAL THR VAL PHE PHE VAL TRP ILE LYS
SEQRES 45 C 968 LEU PHE LYS PHE ILE ASN PHE ASN ARG THR MET SER GLN
SEQRES 46 C 968 LEU SER THR THR MET SER ARG CYS ALA LYS ASP LEU PHE
SEQRES 47 C 968 GLY PHE ALA ILE MET PHE PHE ILE ILE PHE LEU ALA TYR
SEQRES 48 C 968 ALA GLN LEU ALA TYR LEU VAL PHE GLY THR GLN VAL ASP
SEQRES 49 C 968 ASP PHE SER THR PHE GLN GLU CYS ILE PHE THR GLN PHE
SEQRES 50 C 968 ARG ILE ILE LEU GLY ASP ILE ASN PHE ALA GLU ILE GLU
SEQRES 51 C 968 GLU ALA ASN ARG VAL LEU GLY PRO ILE TYR PHE THR THR
SEQRES 52 C 968 PHE VAL PHE PHE MET PHE PHE ILE LEU LEU ASN MET PHE
SEQRES 53 C 968 LEU ALA ILE ILE ASN ASP THR TYR SER GLU VAL LYS SER
SEQRES 54 C 968 ASP LEU ALA GLN GLN LYS ALA GLU MET GLU LEU SER ASP
SEQRES 55 C 968 LEU ILE ARG LYS GLY TYR HIS LYS ALA LEU VAL LYS LEU
SEQRES 56 C 968 LYS LEU LYS LYS ASN THR VAL ASP ASP ILE SER GLU SER
SEQRES 57 C 968 LEU ARG GLN GLY GLY GLY LYS LEU ASN PHE ASP GLU LEU
SEQRES 58 C 968 ARG GLN ASP LEU LYS GLY LYS GLY HIS THR ASP ALA GLU
SEQRES 59 C 968 ILE GLU ALA ILE PHE THR LYS TYR ASP GLN ASP GLY ASP
SEQRES 60 C 968 GLN GLU LEU THR GLU HIS GLU HIS GLN GLN MET ARG ASP
SEQRES 61 C 968 ASP LEU GLU LYS GLU ARG GLU ASP LEU ASP LEU ASP HIS
SEQRES 62 C 968 SER SER LEU PRO ARG PRO MET SER SER ARG SER PHE PRO
SEQRES 63 C 968 ARG SER LEU ASP ASP SER GLU GLU ASP ASP ASP GLU ASP
SEQRES 64 C 968 SER GLY HIS SER SER ARG ARG ARG GLY SER ILE SER SER
SEQRES 65 C 968 GLY VAL SER TYR GLU GLU PHE GLN VAL LEU VAL ARG ARG
SEQRES 66 C 968 VAL ASP ARG MET GLU HIS SER ILE GLY SER ILE VAL SER
SEQRES 67 C 968 LYS ILE ASP ALA VAL ILE VAL LYS LEU GLU ILE MET GLU
SEQRES 68 C 968 ARG ALA LYS LEU LYS ARG ARG GLU VAL LEU GLY ARG LEU
SEQRES 69 C 968 LEU ASP GLY VAL ALA GLU ASP GLU ARG LEU GLY ARG ASP
SEQRES 70 C 968 SER GLU ILE HIS ARG GLU GLN MET GLU ARG LEU VAL ARG
SEQRES 71 C 968 GLU GLU LEU GLU ARG TRP GLU SER ASP ASP ALA ALA SER
SEQRES 72 C 968 GLN ILE SER HIS GLY LEU GLY THR PRO VAL GLY LEU ASN
SEQRES 73 C 968 GLY GLN PRO ARG PRO ARG SER SER ARG PRO SER SER SER
SEQRES 74 C 968 GLN SER THR GLU GLY MET GLU GLY ALA GLY GLY ASN GLY
SEQRES 75 C 968 SER SER ASN VAL HIS VAL
SEQRES 1 D 968 MET VAL ASN SER SER ARG VAL GLN PRO GLN GLN PRO GLY
SEQRES 2 D 968 ASP ALA LYS ARG PRO PRO ALA PRO ARG ALA PRO ASP PRO
SEQRES 3 D 968 GLY ARG LEU MET ALA GLY CYS ALA ALA VAL GLY ALA SER
SEQRES 4 D 968 LEU ALA ALA PRO GLY GLY LEU CYS GLU GLN ARG GLY LEU
SEQRES 5 D 968 GLU ILE GLU MET GLN ARG ILE ARG GLN ALA ALA ALA ARG
SEQRES 6 D 968 ASP PRO PRO ALA GLY ALA ALA ALA SER PRO SER PRO PRO
SEQRES 7 D 968 LEU SER SER CYS SER ARG GLN ALA TRP SER ARG ASP ASN
SEQRES 8 D 968 PRO GLY PHE GLU ALA GLU GLU GLU GLU GLU GLU VAL GLU
SEQRES 9 D 968 GLY GLU GLU GLY GLY MET VAL VAL GLU MET ASP VAL GLU
SEQRES 10 D 968 TRP ARG PRO GLY SER ARG ARG SER ALA ALA SER SER ALA
SEQRES 11 D 968 VAL SER SER VAL GLY ALA ARG SER ARG GLY LEU GLY GLY
SEQRES 12 D 968 TYR HIS GLY ALA GLY HIS PRO SER GLY ARG ARG ARG ARG
SEQRES 13 D 968 ARG GLU ASP GLN GLY PRO PRO CYS PRO SER PRO VAL GLY
SEQRES 14 D 968 GLY GLY ASP PRO LEU HIS ARG HIS LEU PRO LEU GLU GLY
SEQRES 15 D 968 GLN PRO PRO ARG VAL ALA TRP ALA GLU ARG LEU VAL ARG
SEQRES 16 D 968 GLY LEU ARG GLY LEU TRP GLY THR ARG LEU MET GLU GLU
SEQRES 17 D 968 SER SER THR ASN ARG GLU LYS TYR LEU LYS SER VAL LEU
SEQRES 18 D 968 ARG GLU LEU VAL THR TYR LEU LEU PHE LEU ILE VAL LEU
SEQRES 19 D 968 CYS ILE LEU THR TYR GLY MET MET SER SER ASN VAL TYR
SEQRES 20 D 968 TYR TYR THR ARG MET MET SER GLN LEU PHE LEU ASP THR
SEQRES 21 D 968 PRO VAL SER LYS THR GLU LYS THR ASN PHE LYS THR LEU
SEQRES 22 D 968 SER SER MET GLU ASP PHE TRP LYS PHE THR GLU GLY SER
SEQRES 23 D 968 LEU LEU ASP GLY LEU TYR TRP LYS MET GLN PRO SER ASN
SEQRES 24 D 968 GLN THR GLU ALA ASP ASN ARG SER PHE ILE PHE TYR GLU
SEQRES 25 D 968 ASN LEU LEU LEU GLY VAL PRO ARG ILE ARG GLN LEU ARG
SEQRES 26 D 968 VAL ARG ASN GLY SER CYS SER ILE PRO GLN ASP LEU ARG
SEQRES 27 D 968 ASP GLU ILE LYS GLU CYS TYR ASP VAL TYR SER VAL SER
SEQRES 28 D 968 SER GLU ASP ARG ALA PRO PHE GLY PRO ARG ASN GLY THR
SEQRES 29 D 968 ALA TRP ILE TYR THR SER GLU LYS ASP LEU ASN GLY SER
SEQRES 30 D 968 SER HIS TRP GLY ILE ILE ALA THR TYR SER GLY ALA GLY
SEQRES 31 D 968 TYR TYR LEU ASP LEU SER ARG THR ARG GLU GLU THR ALA
SEQRES 32 D 968 ALA GLN VAL ALA SER LEU LYS LYS ASN VAL TRP LEU ASP
SEQRES 33 D 968 ARG GLY THR ARG ALA THR PHE ILE ASP PHE SER VAL TYR
SEQRES 34 D 968 ASN ALA ASN ILE ASN LEU PHE CYS VAL VAL ARG LEU LEU
SEQRES 35 D 968 VAL GLU PHE PRO ALA THR GLY GLY VAL ILE PRO SER TRP
SEQRES 36 D 968 GLN PHE GLN PRO LEU LYS LEU ILE ARG TYR VAL THR THR
SEQRES 37 D 968 PHE ASP PHE PHE LEU ALA ALA CYS GLU ILE ILE PHE CYS
SEQRES 38 D 968 PHE PHE ILE PHE TYR TYR VAL VAL GLU GLU ILE LEU GLU
SEQRES 39 D 968 ILE ARG ILE HIS LYS LEU HIS TYR PHE ARG SER PHE TRP
SEQRES 40 D 968 ASN CYS LEU ASP VAL VAL ILE VAL VAL LEU SER VAL VAL
SEQRES 41 D 968 ALA ILE GLY ILE ASN ILE TYR ARG THR SER ASN VAL GLU
SEQRES 42 D 968 VAL LEU LEU GLN PHE LEU GLU ASP GLN ASN THR PHE PRO
SEQRES 43 D 968 ASN PHE GLU HIS LEU ALA TYR TRP GLN ILE GLN PHE ASN
SEQRES 44 D 968 ASN ILE ALA ALA VAL THR VAL PHE PHE VAL TRP ILE LYS
SEQRES 45 D 968 LEU PHE LYS PHE ILE ASN PHE ASN ARG THR MET SER GLN
SEQRES 46 D 968 LEU SER THR THR MET SER ARG CYS ALA LYS ASP LEU PHE
SEQRES 47 D 968 GLY PHE ALA ILE MET PHE PHE ILE ILE PHE LEU ALA TYR
SEQRES 48 D 968 ALA GLN LEU ALA TYR LEU VAL PHE GLY THR GLN VAL ASP
SEQRES 49 D 968 ASP PHE SER THR PHE GLN GLU CYS ILE PHE THR GLN PHE
SEQRES 50 D 968 ARG ILE ILE LEU GLY ASP ILE ASN PHE ALA GLU ILE GLU
SEQRES 51 D 968 GLU ALA ASN ARG VAL LEU GLY PRO ILE TYR PHE THR THR
SEQRES 52 D 968 PHE VAL PHE PHE MET PHE PHE ILE LEU LEU ASN MET PHE
SEQRES 53 D 968 LEU ALA ILE ILE ASN ASP THR TYR SER GLU VAL LYS SER
SEQRES 54 D 968 ASP LEU ALA GLN GLN LYS ALA GLU MET GLU LEU SER ASP
SEQRES 55 D 968 LEU ILE ARG LYS GLY TYR HIS LYS ALA LEU VAL LYS LEU
SEQRES 56 D 968 LYS LEU LYS LYS ASN THR VAL ASP ASP ILE SER GLU SER
SEQRES 57 D 968 LEU ARG GLN GLY GLY GLY LYS LEU ASN PHE ASP GLU LEU
SEQRES 58 D 968 ARG GLN ASP LEU LYS GLY LYS GLY HIS THR ASP ALA GLU
SEQRES 59 D 968 ILE GLU ALA ILE PHE THR LYS TYR ASP GLN ASP GLY ASP
SEQRES 60 D 968 GLN GLU LEU THR GLU HIS GLU HIS GLN GLN MET ARG ASP
SEQRES 61 D 968 ASP LEU GLU LYS GLU ARG GLU ASP LEU ASP LEU ASP HIS
SEQRES 62 D 968 SER SER LEU PRO ARG PRO MET SER SER ARG SER PHE PRO
SEQRES 63 D 968 ARG SER LEU ASP ASP SER GLU GLU ASP ASP ASP GLU ASP
SEQRES 64 D 968 SER GLY HIS SER SER ARG ARG ARG GLY SER ILE SER SER
SEQRES 65 D 968 GLY VAL SER TYR GLU GLU PHE GLN VAL LEU VAL ARG ARG
SEQRES 66 D 968 VAL ASP ARG MET GLU HIS SER ILE GLY SER ILE VAL SER
SEQRES 67 D 968 LYS ILE ASP ALA VAL ILE VAL LYS LEU GLU ILE MET GLU
SEQRES 68 D 968 ARG ALA LYS LEU LYS ARG ARG GLU VAL LEU GLY ARG LEU
SEQRES 69 D 968 LEU ASP GLY VAL ALA GLU ASP GLU ARG LEU GLY ARG ASP
SEQRES 70 D 968 SER GLU ILE HIS ARG GLU GLN MET GLU ARG LEU VAL ARG
SEQRES 71 D 968 GLU GLU LEU GLU ARG TRP GLU SER ASP ASP ALA ALA SER
SEQRES 72 D 968 GLN ILE SER HIS GLY LEU GLY THR PRO VAL GLY LEU ASN
SEQRES 73 D 968 GLY GLN PRO ARG PRO ARG SER SER ARG PRO SER SER SER
SEQRES 74 D 968 GLN SER THR GLU GLY MET GLU GLY ALA GLY GLY ASN GLY
SEQRES 75 D 968 SER SER ASN VAL HIS VAL
HET NAG E 1 14
HET NAG E 2 14
HET NAG F 1 14
HET NAG F 2 14
HET NAG G 1 14
HET NAG G 2 14
HET NAG A1001 14
HET NAG A1002 14
HET CHS A1005 15
HET CHS A1006 15
HET PX6 A1007 40
HET PLM A1008 18
HET PLM A1009 18
HET PLM A1010 18
HET CA A1011 1
HET CA A1012 1
HET NAG B1001 14
HET NAG B1002 14
HET CHS B1005 15
HET CHS B1006 15
HET PX6 B1007 40
HET PLM B1008 18
HET PLM B1009 18
HET PLM B1010 18
HET NAG C1001 14
HET NAG C1002 14
HET CHS C1005 15
HET CHS C1006 15
HET PX6 C1007 40
HET PLM C1008 18
HET PLM C1009 18
HET PLM C1010 18
HET NAG D1001 14
HET NAG D1002 14
HET NAG D1003 14
HET NAG D1004 14
HET CHS D1005 15
HET CHS D1006 15
HET PX6 D1007 40
HET PLM D1008 18
HET PLM D1009 18
HET PLM D1010 18
HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE
HETNAM CHS 4-AMINO-5-CYCLOHEXYL-3-HYDROXY-PENTANOIC ACID
HETNAM PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE
HETNAM PLM PALMITIC ACID
HETNAM CA CALCIUM ION
FORMUL 5 NAG 16(C8 H15 N O6)
FORMUL 10 CHS 8(C11 H21 N O3)
FORMUL 12 PX6 4(C35 H68 O8 P 1-)
FORMUL 13 PLM 12(C16 H32 O2)
FORMUL 16 CA 2(CA 2+)
HELIX 1 AA1 LYS A 215 MET A 242 1 28
HELIX 2 AA2 ASN A 245 GLN A 255 1 11
HELIX 3 AA3 MET A 276 ASP A 278 5 3
HELIX 4 AA4 PHE A 279 GLU A 284 1 6
HELIX 5 AA5 SER A 286 LEU A 291 1 6
HELIX 6 AA6 GLN A 335 GLU A 340 5 6
HELIX 7 AA7 ASN A 362 ILE A 367 5 6
HELIX 8 AA8 THR A 398 ASN A 412 1 15
HELIX 9 AA9 PHE A 469 HIS A 498 1 30
HELIX 10 AB1 ASN A 508 GLN A 542 1 35
HELIX 11 AB2 PHE A 548 ASN A 578 1 31
HELIX 12 AB3 ARG A 581 CYS A 593 1 13
HELIX 13 AB4 ALA A 594 GLY A 620 1 27
HELIX 14 AB5 THR A 628 GLY A 642 1 15
HELIX 15 AB6 ASN A 645 ASN A 653 1 9
HELIX 16 AB7 PRO A 658 GLN A 693 1 36
HELIX 17 AB8 TYR B 216 MET B 242 1 27
HELIX 18 AB9 ASN B 245 GLN B 255 1 11
HELIX 19 AC1 MET B 276 ASP B 278 5 3
HELIX 20 AC2 PHE B 279 GLU B 284 1 6
HELIX 21 AC3 SER B 286 LEU B 291 1 6
HELIX 22 AC4 GLN B 335 GLU B 340 5 6
HELIX 23 AC5 ASN B 362 ILE B 367 5 6
HELIX 24 AC6 THR B 398 ASN B 412 1 15
HELIX 25 AC7 PHE B 469 HIS B 498 1 30
HELIX 26 AC8 ASN B 508 GLN B 542 1 35
HELIX 27 AC9 PHE B 548 ASN B 578 1 31
HELIX 28 AD1 ARG B 581 CYS B 593 1 13
HELIX 29 AD2 ALA B 594 GLY B 620 1 27
HELIX 30 AD3 THR B 628 GLY B 642 1 15
HELIX 31 AD4 ASN B 645 ASN B 653 1 9
HELIX 32 AD5 PRO B 658 GLN B 693 1 36
HELIX 33 AD6 TYR C 216 MET C 242 1 27
HELIX 34 AD7 ASN C 245 GLN C 255 1 11
HELIX 35 AD8 MET C 276 ASP C 278 5 3
HELIX 36 AD9 PHE C 279 GLU C 284 1 6
HELIX 37 AE1 SER C 286 LEU C 291 1 6
HELIX 38 AE2 GLN C 335 GLU C 340 5 6
HELIX 39 AE3 ASN C 362 ILE C 367 5 6
HELIX 40 AE4 THR C 398 ASN C 412 1 15
HELIX 41 AE5 PHE C 469 HIS C 498 1 30
HELIX 42 AE6 ASN C 508 GLN C 542 1 35
HELIX 43 AE7 PHE C 548 ASN C 578 1 31
HELIX 44 AE8 ARG C 581 CYS C 593 1 13
HELIX 45 AE9 ALA C 594 GLY C 620 1 27
HELIX 46 AF1 THR C 628 GLY C 642 1 15
HELIX 47 AF2 ASN C 645 ASN C 653 1 9
HELIX 48 AF3 PRO C 658 GLN C 693 1 36
HELIX 49 AF4 TYR D 216 MET D 242 1 27
HELIX 50 AF5 ASN D 245 GLN D 255 1 11
HELIX 51 AF6 MET D 276 ASP D 278 5 3
HELIX 52 AF7 PHE D 279 GLU D 284 1 6
HELIX 53 AF8 SER D 286 LEU D 291 1 6
HELIX 54 AF9 GLN D 335 GLU D 340 5 6
HELIX 55 AG1 ASN D 362 ILE D 367 5 6
HELIX 56 AG2 THR D 398 ASN D 412 1 15
HELIX 57 AG3 PHE D 469 HIS D 498 1 30
HELIX 58 AG4 ASN D 508 GLN D 542 1 35
HELIX 59 AG5 PHE D 548 ASN D 578 1 31
HELIX 60 AG6 ARG D 581 CYS D 593 1 13
HELIX 61 AG7 ALA D 594 GLY D 620 1 27
HELIX 62 AG8 THR D 628 GLY D 642 1 15
HELIX 63 AG9 ASN D 645 ASN D 653 1 9
HELIX 64 AH1 PRO D 658 GLN D 693 1 36
SHEET 1 AA1 5 LEU A 393 ASP A 394 0
SHEET 2 AA1 5 ARG A 320 ILE A 321 -1 N ILE A 321 O LEU A 393
SHEET 3 AA1 5 ALA A 421 TYR A 429 -1 O ASP A 425 N ARG A 320
SHEET 4 AA1 5 LEU A 442 GLU A 444 -1 O VAL A 443 N THR A 422
SHEET 5 AA1 5 ILE A 452 PRO A 453 -1 O ILE A 452 N GLU A 444
SHEET 1 AA2 5 LEU A 393 ASP A 394 0
SHEET 2 AA2 5 ARG A 320 ILE A 321 -1 N ILE A 321 O LEU A 393
SHEET 3 AA2 5 ALA A 421 TYR A 429 -1 O ASP A 425 N ARG A 320
SHEET 4 AA2 5 PHE A 436 ARG A 440 -1 O CYS A 437 N VAL A 428
SHEET 5 AA2 5 GLN A 456 LEU A 460 -1 O LEU A 460 N PHE A 436
SHEET 1 AA3 5 LEU B 393 ASP B 394 0
SHEET 2 AA3 5 ARG B 320 ILE B 321 -1 N ILE B 321 O LEU B 393
SHEET 3 AA3 5 ALA B 421 TYR B 429 -1 O ASP B 425 N ARG B 320
SHEET 4 AA3 5 LEU B 442 GLU B 444 -1 O VAL B 443 N THR B 422
SHEET 5 AA3 5 ILE B 452 PRO B 453 -1 O ILE B 452 N GLU B 444
SHEET 1 AA4 5 LEU B 393 ASP B 394 0
SHEET 2 AA4 5 ARG B 320 ILE B 321 -1 N ILE B 321 O LEU B 393
SHEET 3 AA4 5 ALA B 421 TYR B 429 -1 O ASP B 425 N ARG B 320
SHEET 4 AA4 5 PHE B 436 ARG B 440 -1 O CYS B 437 N VAL B 428
SHEET 5 AA4 5 GLN B 456 LEU B 460 -1 O LEU B 460 N PHE B 436
SHEET 1 AA5 5 LEU C 393 ASP C 394 0
SHEET 2 AA5 5 ARG C 320 ILE C 321 -1 N ILE C 321 O LEU C 393
SHEET 3 AA5 5 ALA C 421 TYR C 429 -1 O ASP C 425 N ARG C 320
SHEET 4 AA5 5 LEU C 442 GLU C 444 -1 O VAL C 443 N THR C 422
SHEET 5 AA5 5 ILE C 452 PRO C 453 -1 O ILE C 452 N GLU C 444
SHEET 1 AA6 5 LEU C 393 ASP C 394 0
SHEET 2 AA6 5 ARG C 320 ILE C 321 -1 N ILE C 321 O LEU C 393
SHEET 3 AA6 5 ALA C 421 TYR C 429 -1 O ASP C 425 N ARG C 320
SHEET 4 AA6 5 PHE C 436 ARG C 440 -1 O CYS C 437 N VAL C 428
SHEET 5 AA6 5 GLN C 456 LEU C 460 -1 O LEU C 460 N PHE C 436
SHEET 1 AA7 5 LEU D 393 ASP D 394 0
SHEET 2 AA7 5 ARG D 320 ILE D 321 -1 N ILE D 321 O LEU D 393
SHEET 3 AA7 5 ALA D 421 TYR D 429 -1 O ASP D 425 N ARG D 320
SHEET 4 AA7 5 LEU D 442 GLU D 444 -1 O VAL D 443 N THR D 422
SHEET 5 AA7 5 ILE D 452 PRO D 453 -1 O ILE D 452 N GLU D 444
SHEET 1 AA8 5 LEU D 393 ASP D 394 0
SHEET 2 AA8 5 ARG D 320 ILE D 321 -1 N ILE D 321 O LEU D 393
SHEET 3 AA8 5 ALA D 421 TYR D 429 -1 O ASP D 425 N ARG D 320
SHEET 4 AA8 5 PHE D 436 ARG D 440 -1 O CYS D 437 N VAL D 428
SHEET 5 AA8 5 GLN D 456 LEU D 460 -1 O LEU D 460 N PHE D 436
LINK ND2 ASN A 305 C1 NAG A1001 1555 1555 1.44
LINK ND2 ASN A 362 C1 NAG A1002 1555 1555 1.41
LINK ND2 ASN A 375 C1 NAG E 1 1555 1555 1.47
LINK ND2 ASN B 305 C1 NAG B1001 1555 1555 1.44
LINK ND2 ASN B 362 C1 NAG B1002 1555 1555 1.41
LINK ND2 ASN B 375 C1 NAG F 1 1555 1555 1.47
LINK ND2 ASN C 305 C1 NAG C1001 1555 1555 1.44
LINK ND2 ASN C 362 C1 NAG C1002 1555 1555 1.41
LINK ND2 ASN C 375 C1 NAG G 1 1555 1555 1.47
LINK ND2 ASN D 305 C1 NAG D1001 1555 1555 1.46
LINK ND2 ASN D 362 C1 NAG D1002 1555 1555 1.41
LINK ND2 ASN D 375 C1 NAG D1003 1555 1555 1.47
LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.54
LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.53
LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.55
CISPEP 1 GLY A 359 PRO A 360 0 7.87
CISPEP 2 ALA A 384 THR A 385 0 18.63
CISPEP 3 LEU A 656 GLY A 657 0 -1.40
CISPEP 4 GLY B 359 PRO B 360 0 7.85
CISPEP 5 ALA B 384 THR B 385 0 18.59
CISPEP 6 LEU B 656 GLY B 657 0 -1.51
CISPEP 7 GLY C 359 PRO C 360 0 7.78
CISPEP 8 ALA C 384 THR C 385 0 18.52
CISPEP 9 LEU C 656 GLY C 657 0 -1.49
CISPEP 10 GLY D 359 PRO D 360 0 7.86
CISPEP 11 ALA D 384 THR D 385 0 18.68
CISPEP 12 LEU D 656 GLY D 657 0 -1.48
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
